SIMILAR PATTERNS OF AMINO ACIDS FOR 5IKR_B_ID8B602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkp PHYTASE

(Escherichia
coli) 		PF00328
(His_Phos_2) 		5 VAL A  32
LEU A 177
LEU A 170
GLY A 209
ALA A 210
 None
 1.08A 5ikrB-1dkpA:
undetectable		 5ikrB-1dkpA:
22.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		10 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.42A 5ikrB-1ebvA:
58.5		 5ikrB-1ebvA:
63.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f59 IMPORTIN BETA-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 VAL A  43
LEU A  44
LEU A   3
TYR A 104
ALA A  56
 None
 1.11A 5ikrB-1f59A:
0.0		 5ikrB-1f59A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8d RIBOFLAVIN SYNTHASE

(Escherichia
coli) 		PF00677
(Lum_binding) 		5 VAL A  59
LEU A  28
GLY A  39
ALA A  40
LEU A  36
 None
 1.11A 5ikrB-1i8dA:
0.0		 5ikrB-1i8dA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF06087
(Tyr-DNA_phospho) 		5 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.99A 5ikrB-1jy1A:
0.0		 5ikrB-1jy1A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvt SHIKIMATE
5'-DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 VAL A 226
TYR A 134
LEU A 238
VAL A 194
LEU A 220
 None
 0.99A 5ikrB-1nvtA:
undetectable		 5ikrB-1nvtA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q77 HYPOTHETICAL PROTEIN
AQ_178

(Aquifex
aeolicus) 		PF00582
(Usp) 		5 VAL A 102
LEU A   4
VAL A 123
GLY A 126
LEU A 129
 None
 0.96A 5ikrB-1q77A:
undetectable		 5ikrB-1q77A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhg ATP-DEPENDENT
HELICASE PCRA

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 VAL A  40
LEU A  41
GLY A 250
ALA A  31
LEU A 282
 None
 1.11A 5ikrB-1qhgA:
0.0		 5ikrB-1qhgA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 LEU A 469
LEU A 437
VAL A 505
SER A 730
LEU A 577
 None
 1.11A 5ikrB-1rrhA:
0.0		 5ikrB-1rrhA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum) 		PF01593
(Amino_oxidase) 		5 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
 None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
 1.04A 5ikrB-1sezA:
0.0		 5ikrB-1sezA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
MEDIUM SUBUNIT

(Pseudomonas
putida) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 LEU C  50
LEU C  21
GLY C  32
ALA C  31
LEU C  53
 None
None
GOL  C3907 ( 3.4A)
FAD  C4931 (-3.5A)
None
 1.07A 5ikrB-1t3qC:
undetectable		 5ikrB-1t3qC:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 104
GLY A 349
ALA A 350
SER A 353
LEU A 354
 None
 1.11A 5ikrB-1tqyA:
undetectable		 5ikrB-1tqyA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukc ESTA

(Aspergillus
niger) 		PF00135
(COesterase) 		5 LEU A 220
LEU A 316
VAL A 236
GLY A 208
ALA A 213
 None
 1.11A 5ikrB-1ukcA:
undetectable		 5ikrB-1ukcA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usp ORGANIC
HYDROPEROXIDE
RESISTANCE PROTEIN

(Deinococcus
radiodurans) 		PF02566
(OsmC) 		5 LEU B 113
LEU B 135
VAL B  65
GLY B  63
ALA B  61
 None
 1.04A 5ikrB-1uspB:
undetectable		 5ikrB-1uspB:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xcr HYPOTHETICAL PROTEIN
PTD012

(Homo sapiens) 		PF08925
(DUF1907) 		5 ARG A 302
VAL A 254
LEU A 264
GLY A 259
LEU A 300
 None
 1.01A 5ikrB-1xcrA:
undetectable		 5ikrB-1xcrA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0u INITIATION FACTOR 2B

(Leishmania
major) 		PF01008
(IF-2B) 		5 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.11A 5ikrB-2a0uA:
undetectable		 5ikrB-2a0uA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aiz OUTER MEMBRANE
PROTEIN P6

(Haemophilus
influenzae) 		PF00691
(OmpA) 		5 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 1.07A 5ikrB-2aizP:
undetectable		 5ikrB-2aizP:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ark FLAVODOXIN

(Aquifex
aeolicus) 		PF00258
(Flavodoxin_1) 		5 VAL A   6
LEU A  36
GLY A  25
ALA A  26
LEU A 158
 None
 1.10A 5ikrB-2arkA:
undetectable		 5ikrB-2arkA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE

(Plasmodium
falciparum) 		PF01048
(PNP_UDP_1) 		5 VAL A  21
LEU A  20
LEU A  78
GLY A 201
LEU A 188
 None
 1.07A 5ikrB-2bsxA:
undetectable		 5ikrB-2bsxA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486

(Thermus
thermophilus) 		PF01894
(UPF0047) 		5 VAL A  34
LEU A 128
LEU A  36
GLY A 101
LEU A 103
 None
 0.98A 5ikrB-2cu5A:
undetectable		 5ikrB-2cu5A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like) 		5 LEU A 299
VAL A 260
GLY A 262
ALA A 261
SER A 316
 None
 1.04A 5ikrB-2cw6A:
undetectable		 5ikrB-2cw6A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE

(Pseudomonas
aeruginosa) 		PF00682
(HMGL-like) 		5 VAL A 274
LEU A 273
GLY A 236
ALA A 235
SER A 290
 None
 1.08A 5ikrB-2ftpA:
undetectable		 5ikrB-2ftpA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk9 PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE II,
GAMMA

(Homo sapiens) 		PF01504
(PIP5K) 		5 LEU A 126
TYR A 189
GLY A  54
ALA A  56
SER A  58
 None
 1.02A 5ikrB-2gk9A:
undetectable		 5ikrB-2gk9A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 238
TYR A 194
VAL A 227
GLY A 171
ALA A 229
 None
 1.08A 5ikrB-2j6iA:
undetectable		 5ikrB-2j6iA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjr PROTEIN (HELICASE
PCRA)

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 VAL A  40
LEU A  41
GLY A 250
ALA A  31
LEU A 282
 None
 1.07A 5ikrB-2pjrA:
undetectable		 5ikrB-2pjrA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0x UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF08538
(DUF1749) 		5 LEU A 121
LEU A 126
VAL A  44
ALA A 114
LEU A 140
 None
 1.09A 5ikrB-2q0xA:
undetectable		 5ikrB-2q0xA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w48 SORBITOL OPERON
REGULATOR

(Klebsiella
pneumoniae) 		PF04198
(Sugar-bind)
PF13936
(HTH_38) 		5 VAL A 304
LEU A 303
LEU A 102
GLY A 211
LEU A 124
 None
None
None
GOL  A1316 (-3.1A)
None
 1.00A 5ikrB-2w48A:
undetectable		 5ikrB-2w48A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 LEU A 137
LEU A 121
VAL A  79
GLY A  76
ALA A 132
 None
None
None
None
GOL  A 770 (-3.8A)
 1.05A 5ikrB-2x58A:
undetectable		 5ikrB-2x58A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xec PUTATIVE MALEATE
ISOMERASE

(Nocardia
farcinica) 		no annotation 5 LEU A 158
VAL A 174
ALA A 178
SER A 180
LEU A 181
 None
 0.91A 5ikrB-2xecA:
undetectable		 5ikrB-2xecA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn8 PUTATIVE CYTOCHROME
P450 125

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 VAL A 313
LEU A 415
VAL A 267
GLY A 269
ALA A 268
 HEM  A1434 ( 4.9A)
None
None
HEM  A1434 (-3.3A)
HEM  A1434 (-3.5A)
 1.01A 5ikrB-2xn8A:
undetectable		 5ikrB-2xn8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu2 UPF0271 PROTEIN
PA4511

(Pseudomonas
aeruginosa) 		PF03746
(LamB_YcsF) 		5 VAL A 149
LEU A 150
LEU A 169
GLY A 126
LEU A 131
 None
 1.05A 5ikrB-2xu2A:
undetectable		 5ikrB-2xu2A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE
IRON-SULFUR
ATP-BINDING PROTEIN

(Prochlorococcus
marinus) 		PF00142
(Fer4_NifH) 		5 VAL A 152
LEU A 153
GLY A 159
ALA A 162
LEU A 165
 None
 1.06A 5ikrB-2ynmA:
undetectable		 5ikrB-2ynmA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Thermus
thermophilus) 		PF01174
(SNO) 		6 VAL A 161
LEU A 160
LEU A 144
GLY A  79
ALA A  84
LEU A 103
 None
 1.25A 5ikrB-2ywdA:
undetectable		 5ikrB-2ywdA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a6p EXPORTIN-5

(Homo sapiens) 		PF08389
(Xpo1) 		5 VAL A 896
LEU A 899
LEU A 972
VAL A 912
LEU A 919
 None
 1.10A 5ikrB-3a6pA:
undetectable		 5ikrB-3a6pA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3at7 ALGINATE-BINDING
FLAGELLIN

(Sphingomonas
sp. A1) 		PF09375
(Peptidase_M75) 		5 LEU A  87
VAL A 158
GLY A 160
ALA A 162
LEU A 165
 None
 1.08A 5ikrB-3at7A:
undetectable		 5ikrB-3at7A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5t MALATE DEHYDROGENASE

(Burkholderia
pseudomallei) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A  21
LEU A  58
VAL A  10
GLY A  12
ALA A  13
 None
 1.09A 5ikrB-3d5tA:
undetectable		 5ikrB-3d5tA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhn NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Bacteroides
thetaiotaomicron) 		PF13460
(NAD_binding_10) 		5 VAL A  31
LEU A  25
VAL A  35
GLY A  11
ALA A  12
 None
 1.07A 5ikrB-3dhnA:
undetectable		 5ikrB-3dhnA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwi CYSTEINE SYNTHASE B

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		5 LEU A 291
LEU A 189
GLY A 267
ALA A 268
SER A 265
 None
None
None
None
PLP  A 401 (-2.6A)
 1.01A 5ikrB-3dwiA:
undetectable		 5ikrB-3dwiA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A   4
TYR A 203
LEU A 206
GLY A  71
SER A  36
 None
 1.06A 5ikrB-3e7wA:
undetectable		 5ikrB-3e7wA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efb PROBABLE SOR-OPERON
REGULATOR

(Shigella
flexneri) 		PF04198
(Sugar-bind) 		5 VAL A 254
LEU A 253
LEU A  52
GLY A 161
LEU A  74
 None
 0.96A 5ikrB-3efbA:
undetectable		 5ikrB-3efbA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19

(Rhodobacter
sphaeroides) 		PF01244
(Peptidase_M19) 		5 VAL A 219
LEU A 222
LEU A 206
GLY A 187
LEU A 211
 None
 1.10A 5ikrB-3fdgA:
undetectable		 5ikrB-3fdgA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj1 PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Ruegeria
pomeroyi) 		PF01380
(SIS) 		5 VAL A 121
LEU A  95
VAL A  30
ALA A  34
LEU A  37
 None
 1.11A 5ikrB-3fj1A:
1.6		 5ikrB-3fj1A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307

([Ruminococcus]
gnavus) 		PF02645
(DegV) 		5 VAL A 263
LEU A 230
LEU A 267
VAL A 179
GLY A 293
 None
 1.07A 5ikrB-3jr7A:
1.3		 5ikrB-3jr7A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4d STEROL 14-ALPHA
DEMETHYLASE

(Leishmania
infantum) 		PF00067
(p450) 		5 LEU A 260
LEU A 187
VAL A 280
GLY A 282
LEU A 235
 None
 1.05A 5ikrB-3l4dA:
1.3		 5ikrB-3l4dA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la2 GLOBAL NITROGEN
REGULATOR

(Nostoc sp. PCC
7120) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 VAL A 108
LEU A 112
GLY A  76
SER A  79
LEU A  80
 None
None
AKG  A 224 (-3.1A)
None
None
 0.98A 5ikrB-3la2A:
undetectable		 5ikrB-3la2A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npi TETR FAMILY
REGULATORY PROTEIN

(Corynebacterium
diphtheriae) 		PF00440
(TetR_N) 		5 ARG A  95
VAL A 207
LEU A 211
VAL A  91
GLY A  93
 None
 1.00A 5ikrB-3npiA:
undetectable		 5ikrB-3npiA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5g CYAB

(Pseudomonas
aeruginosa) 		PF00211
(Guanylate_cyc) 		5 LEU A 228
TYR A 336
GLY A 291
ALA A 292
LEU A 381
 None
 1.08A 5ikrB-3r5gA:
undetectable		 5ikrB-3r5gA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4a JMB19063

(compost
metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 VAL A 518
LEU A 517
LEU A 555
GLY A 387
LEU A 412
 None
 1.08A 5ikrB-3u4aA:
undetectable		 5ikrB-3u4aA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 LEU A 401
LEU A 563
VAL A 475
GLY A 477
LEU A 482
 None
 1.05A 5ikrB-3ulzA:
undetectable		 5ikrB-3ulzA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
 None
 0.97A 5ikrB-3uw2A:
undetectable		 5ikrB-3uw2A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF09754
(PAC2) 		5 LEU A 124
LEU A  62
GLY A 191
ALA A 189
LEU A  36
 None
None
None
AU  A 303 (-4.1A)
None
 1.04A 5ikrB-3vr0A:
undetectable		 5ikrB-3vr0A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wp5 CDBFV

(Neocallimastix
patriciarum) 		PF00457
(Glyco_hydro_11) 		5 LEU A  59
GLY A 204
ALA A 203
SER A  95
LEU A 117
 None
 0.98A 5ikrB-3wp5A:
undetectable		 5ikrB-3wp5A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		5 LEU A1737
GLY A1842
ALA A1841
SER A1844
LEU A1868
 None
 1.09A 5ikrB-4asiA:
undetectable		 5ikrB-4asiA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c13 UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--L-LYSINE LIGASE

(Staphylococcus
aureus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 TYR A 247
GLY A 216
ALA A 218
SER A 220
LEU A 221
 None
KCX  A 219 ( 4.5A)
KCX  A 219 ( 3.1A)
KCX  A 219 ( 4.3A)
None
 1.12A 5ikrB-4c13A:
undetectable		 5ikrB-4c13A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE

(Gelatoporia
subvermispora) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 VAL A  28
VAL A 112
GLY A 110
ALA A 109
LEU A  90
 None
 1.06A 5ikrB-4czpA:
undetectable		 5ikrB-4czpA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwq TRNA-SPLICING LIGASE
RTCB

(Pyrococcus
horikoshii) 		PF01139
(RtcB) 		5 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.05A 5ikrB-4dwqA:
undetectable		 5ikrB-4dwqA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ev0 TRANSCRIPTION
REGULATOR, CRP
FAMILY

(Thermus
thermophilus) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 VAL A 183
LEU A 187
GLY A 174
ALA A 173
LEU A 169
 None
 1.03A 5ikrB-4ev0A:
undetectable		 5ikrB-4ev0A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6c AUSA REDUCTASE
DOMAIN PROTEIN

(Staphylococcus
aureus) 		PF07993
(NAD_binding_4) 		5 VAL A2229
TYR A2203
GLY A2133
ALA A2132
LEU A2056
 None
 1.11A 5ikrB-4f6cA:
undetectable		 5ikrB-4f6cA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwg TTC1975 PEPTIDASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C)
PF13654
(AAA_32) 		5 LEU A 310
VAL A 335
GLY A 333
ALA A 329
LEU A 330
 None
 1.05A 5ikrB-4fwgA:
undetectable		 5ikrB-4fwgA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		5 LEU A 261
LEU A 188
VAL A 281
GLY A 283
LEU A 236
 None
 0.95A 5ikrB-4g3jA:
0.6		 5ikrB-4g3jA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4heq FLAVODOXIN

(Desulfovibrio
gigas) 		PF00258
(Flavodoxin_1) 		5 VAL A  53
LEU A   5
GLY A  45
ALA A  81
LEU A  83
 None
 1.03A 5ikrB-4heqA:
undetectable		 5ikrB-4heqA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqn SPOROZOITE SURFACE
PROTEIN 2

(Plasmodium
vivax) 		PF00090
(TSP_1)
PF00092
(VWA) 		5 LEU A 168
LEU A 133
GLY A 200
ALA A 199
LEU A 181
 None
 1.09A 5ikrB-4hqnA:
undetectable		 5ikrB-4hqnA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isy CYSTEINE DESULFURASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		5 VAL A 278
LEU A 279
LEU A 371
ALA A 300
LEU A 356
 None
 0.94A 5ikrB-4isyA:
undetectable		 5ikrB-4isyA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9u TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKH

(Vibrio
parahaemolyticus) 		PF02386
(TrkH) 		5 VAL A  79
GLY A  81
ALA A  83
SER A  85
LEU A  86
 None
 0.83A 5ikrB-4j9uA:
1.9		 5ikrB-4j9uA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 VAL A3299
LEU A3063
LEU A3301
TYR A3067
GLY A3413
 None
 0.83A 5ikrB-4kc5A:
undetectable		 5ikrB-4kc5A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Xanthomonas
oryzae) 		PF01156
(IU_nuc_hydro) 		5 VAL A 253
LEU A 227
GLY A 246
ALA A 245
LEU A 241
 None
 1.08A 5ikrB-4kl0A:
undetectable		 5ikrB-4kl0A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY

(Thermococcus
kodakarensis) 		PF00375
(SDF) 		5 VAL A 153
LEU A 154
GLY A 309
ALA A 310
LEU A 284
 None
 1.02A 5ikrB-4ky0A:
undetectable		 5ikrB-4ky0A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN

(Pyrococcus
horikoshii) 		PF00375
(SDF) 		5 VAL A 151
LEU A 152
GLY A 306
ALA A 307
LEU A 282
 None
 1.01A 5ikrB-4oyeA:
undetectable		 5ikrB-4oyeA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		5 LEU A 614
TYR A 609
LEU A 390
GLY A 354
ALA A 355
 None
 1.04A 5ikrB-4p7hA:
undetectable		 5ikrB-4p7hA:
20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 ARG A 121
VAL A 350
LEU A 353
TYR A 356
LEU A 360
TYR A 386
TRP A 388
VAL A 524
ALA A 528
SER A 531
LEU A 532
 BOG  A 604 ( 3.7A)
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.5A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.8A)
None
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
IBP  A 601 ( 4.9A)
 0.66A 5ikrB-4ph9A:
62.8		 5ikrB-4ph9A:
88.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 ARG A 121
VAL A 350
LEU A 353
TYR A 356
LEU A 360
TYR A 386
TRP A 388
VAL A 524
GLY A 527
ALA A 528
LEU A 532
 BOG  A 604 ( 3.7A)
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.5A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.8A)
None
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 4.9A)
 0.44A 5ikrB-4ph9A:
62.8		 5ikrB-4ph9A:
88.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 VAL A1006
LEU A 524
VAL A 967
GLY A 969
ALA A 968
 None
 1.00A 5ikrB-4pj6A:
undetectable		 5ikrB-4pj6A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wuj GLYCOSIDE HYDROLASE
FAMILY 15, CELLULOSE
SIGNALING ASSOCIATED
PROTEIN ENVOY

(Trichoderma
reesei) 		PF13426
(PAS_9) 		5 VAL A 201
LEU A 102
LEU A 203
VAL A  74
GLY A  76
 FMN  A5201 (-4.2A)
None
None
None
None
 0.94A 5ikrB-4wujA:
undetectable		 5ikrB-4wujA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yei BETA1MUT

(synthetic
construct) 		PF00805
(Pentapeptide) 		5 LEU A 182
LEU A 147
GLY A 159
ALA A 160
LEU A 137
 None
 1.11A 5ikrB-4yeiA:
undetectable		 5ikrB-4yeiA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 VAL A 797
LEU A 560
LEU A 799
TYR A 564
GLY A 911
 None
 0.89A 5ikrB-4zdnA:
undetectable		 5ikrB-4zdnA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN

(Candidatus
Nitrososphaera
gargensis) 		PF00561
(Abhydrolase_1) 		5 ARG A 207
VAL A 213
VAL A 203
GLY A 205
SER A 209
 None
 1.01A 5ikrB-5a62A:
undetectable		 5ikrB-5a62A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbn ACETATE
COA-TRANSFERASE
SUBUNIT BETA

(Escherichia
coli) 		PF01144
(CoA_trans) 		5 VAL B  21
LEU B  43
VAL B  11
ALA B  12
LEU B  35
 None
 1.05A 5ikrB-5dbnB:
undetectable		 5ikrB-5dbnB:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		5 ARG A 743
LEU A 773
LEU A 745
GLY A 755
ALA A 754
 None
 1.01A 5ikrB-5h42A:
undetectable		 5ikrB-5h42A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6b ALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		5 LEU A 301
TYR A 376
VAL A 288
ALA A 385
LEU A 365
 None
 1.04A 5ikrB-5j6bA:
undetectable		 5ikrB-5j6bA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkj ESTERASE E22

(uncultured
bacterium) 		PF00561
(Abhydrolase_1) 		5 LEU A 304
LEU A 117
GLY A 239
SER A 243
LEU A 244
 None
 1.09A 5ikrB-5jkjA:
undetectable		 5ikrB-5jkjA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		5 LEU A 301
TYR A 376
VAL A 288
ALA A 385
LEU A 365
 None
 1.01A 5ikrB-5jryA:
undetectable		 5ikrB-5jryA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m32 PROTEASOME SUBUNIT
BETA TYPE-2

(Homo sapiens) 		PF00227
(Proteasome) 		5 LEU J   4
TYR J 117
GLY J 135
ALA J 136
LEU J 140
 None
 1.00A 5ikrB-5m32J:
undetectable		 5ikrB-5m32J:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 1.07A 5ikrB-5nugA:
undetectable		 5ikrB-5nugA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN

(Lactobacillus
reuteri) 		no annotation 5 VAL A 502
LEU A 472
LEU A 536
VAL A 464
LEU A 528
 None
 1.09A 5ikrB-5nxkA:
undetectable		 5ikrB-5nxkA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE

(Leishmania
major) 		no annotation 5 TYR A 234
VAL A 370
ALA A 368
SER A 367
LEU A 280
 None
 0.95A 5ikrB-5nzgA:
undetectable		 5ikrB-5nzgA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uld TRANSPORTER, NADC
FAMILY

(Vibrio cholerae) 		PF00939
(Na_sulph_symp) 		5 LEU A 270
VAL A 295
GLY A 298
ALA A 299
LEU A 303
 None
 0.94A 5ikrB-5uldA:
undetectable		 5ikrB-5uldA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase)
PF12796
(Ank_2) 		6 VAL A 422
LEU A 284
VAL A 429
GLY A 367
ALA A 366
LEU A 362
 None
 1.40A 5ikrB-5uqeA:
undetectable		 5ikrB-5uqeA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Enterococcus
faecalis) 		no annotation 5 LEU A 121
LEU A 133
VAL A  46
GLY A   4
ALA A 116
 None
 1.11A 5ikrB-5v2mA:
undetectable		 5ikrB-5v2mA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1

(Streptococcus
gordonii) 		no annotation 5 LEU A 422
GLY A 451
ALA A 450
SER A 449
LEU A 312
 None
 1.10A 5ikrB-5vaeA:
undetectable		 5ikrB-5vaeA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqk SULFURTRANSFERASE

(Mus musculus) 		PF00581
(Rhodanese) 		5 LEU A 232
VAL A 257
GLY A 260
ALA A 261
SER A 264
 None
 1.11A 5ikrB-5wqkA:
undetectable		 5ikrB-5wqkA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF03828
(PAP_assoc) 		6 LEU A 422
LEU A 437
VAL A 559
GLY A 561
ALA A 560
LEU A 507
 None
 1.30A 5ikrB-5wu3A:
undetectable		 5ikrB-5wu3A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF00076
(RRM_1)
PF03828
(PAP_assoc) 		6 LEU A 422
LEU A 437
VAL A 559
GLY A 561
ALA A 560
LEU A 507
 None
 1.30A 5ikrB-5wu6A:
undetectable		 5ikrB-5wu6A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjj MULTI DRUG EFFLUX
TRANSPORTER

(Camelina sativa) 		PF01554
(MatE) 		5 LEU A 199
LEU A 203
VAL A  54
GLY A  56
ALA A  55
 None
 1.05A 5ikrB-5xjjA:
1.2		 5ikrB-5xjjA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpg UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		no annotation 5 LEU A 174
LEU A 270
TRP A 128
GLY A 149
LEU A 279
 None
 1.11A 5ikrB-5xpgA:
undetectable		 5ikrB-5xpgA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxo PERIPLASMIC
BETA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 VAL A 553
LEU A 552
LEU A 590
GLY A 422
LEU A 447
 None
 1.04A 5ikrB-5xxoA:
undetectable		 5ikrB-5xxoA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq6 THERMOSPERMINE
SYNTHASE

(Medicago
truncatula) 		no annotation 5 VAL A  89
LEU A  88
LEU A  93
GLY A 110
ALA A 113
 None
None
None
CL  A 401 (-3.5A)
CL  A 401 (-3.8A)
 1.07A 5ikrB-6bq6A:
undetectable		 5ikrB-6bq6A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byq TYROSINE--TRNA
LIGASE

(Helicobacter
pylori) 		no annotation 5 LEU A  76
LEU A  63
TRP A 130
GLY A 186
ALA A 187
 None
 1.04A 5ikrB-6byqA:
undetectable		 5ikrB-6byqA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Acinetobacter
baumannii) 		no annotation 5 LEU A 380
LEU A 417
VAL A 445
GLY A 447
SER A 451
 None
 1.00A 5ikrB-6d6kA:
undetectable		 5ikrB-6d6kA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
5

(Mus musculus) 		no annotation 5 LEU L 310
LEU L 317
GLY L 222
ALA L 220
LEU L 217
 None
 1.11A 5ikrB-6g2jL:
undetectable		 5ikrB-6g2jL:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1adr P22 C2 REPRESSOR

(Salmonella
virus P22) 		PF01381
(HTH_3) 		3 SER A  36
LEU A  64
MET A   6
 None
 0.76A 5ikrB-1adrA:
undetectable		 5ikrB-1adrA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avm SUPEROXIDE DISMUTASE

(Propionibacterium
freudenreichii) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 SER A  76
LEU A  15
MET A  82
 None
 0.82A 5ikrB-1avmA:
0.0		 5ikrB-1avmA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bev BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4

(Enterovirus E) 		PF00073
(Rhv) 		3 SER 1 244
LEU 1 105
MET 1 109
 None
None
MYR  1 900 ( 4.9A)
 0.87A 5ikrB-1bev1:
undetectable		 5ikrB-1bev1:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)

(Homo sapiens) 		PF00168
(C2)
PF01735
(PLA2_B) 		3 SER A 230
LEU A 386
MET A 390
 None
 0.78A 5ikrB-1cjyA:
0.0		 5ikrB-1cjyA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1deu PROCATHEPSIN X

(Homo sapiens) 		PF00112
(Peptidase_C1) 		3 SER A 136
LEU A   1
MET A 142
 None
 0.87A 5ikrB-1deuA:
0.0		 5ikrB-1deuA:
17.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		3 SER A 353
LEU A 384
MET A 522
 None
 0.35A 5ikrB-1ebvA:
58.5		 5ikrB-1ebvA:
63.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbw ENDO-1,4-BETA-GLUCAN
ASE F

([Clostridium]
cellulolyticum) 		PF02011
(Glyco_hydro_48) 		3 SER A  37
LEU A  88
MET A  57
 None
 0.83A 5ikrB-1fbwA:
0.0		 5ikrB-1fbwA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h71 SERRALYSIN

(Pseudomonas sp.
'TAC II 18') 		PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		3 SER P 229
LEU P 177
MET P 207
 None
 0.87A 5ikrB-1h71P:
0.0		 5ikrB-1h71P:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikf IGG1-KAPPA R45-45-11
FAB (HEAVY CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H  88
LEU H  81
MET H  83
 None
 0.88A 5ikrB-1ikfH:
undetectable		 5ikrB-1ikfH:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j32 ASPARTATE
AMINOTRANSFERASE

(Phormidium
lapideum) 		PF00155
(Aminotran_1_2) 		3 SER A  36
LEU A 307
MET A 324
 None
 0.84A 5ikrB-1j32A:
0.0		 5ikrB-1j32A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1php 3-PHOSPHOGLYCERATE
KINASE

(Geobacillus
stearothermophilus) 		PF00162
(PGK) 		3 SER A 370
LEU A 338
MET A 366
 None
 0.76A 5ikrB-1phpA:
undetectable		 5ikrB-1phpA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poy SPERMIDINE/PUTRESCIN
E-BINDING PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		3 SER 1 150
LEU 1 165
MET 1 227
 None
 0.72A 5ikrB-1poy1:
undetectable		 5ikrB-1poy1:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh9 ENDO-BETA-MANNANASE

(Solanum
lycopersicum) 		PF00150
(Cellulase) 		3 SER A  91
LEU A 127
MET A 129
 None
 0.85A 5ikrB-1rh9A:
undetectable		 5ikrB-1rh9A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Streptomyces
sp. R61) 		PF00144
(Beta-lactamase) 		3 SER A  86
LEU A 282
MET A 106
 None
 0.61A 5ikrB-1sdeA:
undetectable		 5ikrB-1sdeA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhg OVALBUMIN

(Gallus gallus) 		PF00079
(Serpin) 		3 SER A 307
LEU A 105
MET A 172
 None
 0.72A 5ikrB-1uhgA:
undetectable		 5ikrB-1uhgA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up2 CELA1 PROTEIN

(Mycobacterium
tuberculosis) 		PF01341
(Glyco_hydro_6) 		3 SER A 292
LEU A 208
MET A 256
 None
 0.77A 5ikrB-1up2A:
undetectable		 5ikrB-1up2A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii) 		PF00285
(Citrate_synt) 		3 SER A 314
LEU A 154
MET A 170
 None
 0.88A 5ikrB-1vgpA:
undetectable		 5ikrB-1vgpA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xre SUPEROXIDE DISMUTASE

(Bacillus
anthracis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 SER A  84
LEU A  16
MET A  90
 None
 0.82A 5ikrB-1xreA:
undetectable		 5ikrB-1xreA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xss FLUORESCENT PROTEIN

(Favia favus) 		PF01353
(GFP) 		3 SER A 220
LEU A 156
MET A 149
 None
 0.80A 5ikrB-1xssA:
undetectable		 5ikrB-1xssA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE

(Escherichia
virus T4) 		PF11440
(AGT) 		3 SER A1020
LEU A1310
MET A1178
 None
 0.81A 5ikrB-1xv5A:
undetectable		 5ikrB-1xv5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvy IMMUNOGLOBULIN HEAVY
CHAIN ANTIBODY
VARIABLE DOMAIN

(Camelus
dromedarius) 		PF07686
(V-set) 		3 SER A  88
LEU A  81
MET A  83
 None
 0.86A 5ikrB-1zvyA:
undetectable		 5ikrB-1zvyA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bre ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82

(Saccharomyces
cerevisiae) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 SER A  80
LEU A  89
MET A  84
 None
None
KJ2  A1214 (-4.0A)
 0.85A 5ikrB-2breA:
undetectable		 5ikrB-2breA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgd 223AA LONG
HYPOTHETICAL
ARYLMALONATE
DECARBOXYLASE

(Sulfurisphaera
tokodaii) 		no annotation 3 SER A  32
LEU A 220
MET A  26
 None
 0.76A 5ikrB-2dgdA:
undetectable		 5ikrB-2dgdA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		3 SER A 874
LEU A1016
MET A1056
 None
 0.62A 5ikrB-2ec5A:
undetectable		 5ikrB-2ec5A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9x PUTATIVE SEPTATION
PROTEIN SPOVG

(Staphylococcus
epidermidis) 		PF04026
(SpoVG) 		3 SER A  66
LEU A  25
MET A   1
 None
 0.86A 5ikrB-2i9xA:
undetectable		 5ikrB-2i9xA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9z PUTATIVE SEPTATION
PROTEIN SPOVG

(Staphylococcus
epidermidis) 		PF04026
(SpoVG) 		3 SER A  66
LEU A  25
MET A   1
 None
 0.87A 5ikrB-2i9zA:
undetectable		 5ikrB-2i9zA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idl HYPOTHETICAL PROTEIN

(Streptococcus
pneumoniae) 		PF04327
(Peptidase_Prp) 		3 SER A 103
LEU A  40
MET A  95
 None
 0.75A 5ikrB-2idlA:
undetectable		 5ikrB-2idlA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 SER X 445
LEU X  75
MET X  66
 2MD  X 801 (-2.9A)
None
None
 0.70A 5ikrB-2iv2X:
undetectable		 5ikrB-2iv2X:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjx URIDYLATE KINASE

(Bacillus
anthracis) 		PF00696
(AA_kinase) 		3 SER A 145
LEU A 122
MET A 152
 None
 0.81A 5ikrB-2jjxA:
undetectable		 5ikrB-2jjxA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jv9 SMOOTHELIN-LIKE 1

(Mus musculus) 		PF00307
(CH) 		3 SER A  30
LEU A  81
MET A  86
 None
 0.87A 5ikrB-2jv9A:
undetectable		 5ikrB-2jv9A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q09 IMIDAZOLONEPROPIONAS
E

(unidentified) 		PF01979
(Amidohydro_1) 		3 SER A 315
LEU A 305
MET A 312
 None
 0.76A 5ikrB-2q09A:
undetectable		 5ikrB-2q09A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5k MAJOR CAPSID PROTEIN
L1

(Alphapapillomavirus
10) 		PF00500
(Late_protein_L1) 		3 SER A 393
LEU A 379
MET A 384
 None
 0.82A 5ikrB-2r5kA:
undetectable		 5ikrB-2r5kA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK) 		PF00202
(Aminotran_3) 		3 SER A 383
LEU A 368
MET A 222
 None
SFE  A1447 (-4.9A)
None
 0.58A 5ikrB-2ykyA:
undetectable		 5ikrB-2ykyA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aag GENERAL
GLYCOSYLATION
PATHWAY PROTEIN

(Campylobacter
jejuni) 		PF02516
(STT3) 		3 SER A 536
LEU A 504
MET A 529
 None
 0.60A 5ikrB-3aagA:
undetectable		 5ikrB-3aagA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce2 PUTATIVE PEPTIDASE

(Chlamydia
abortus) 		PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N) 		3 SER A 375
LEU A 350
MET A 406
 None
 0.78A 5ikrB-3ce2A:
1.6		 5ikrB-3ce2A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cky 2-HYDROXYMETHYL
GLUTARATE
DEHYDROGENASE

(Eubacterium
barkeri) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		3 SER A 213
LEU A 200
MET A 205
 None
 0.87A 5ikrB-3ckyA:
undetectable		 5ikrB-3ckyA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		3 SER A 355
LEU A 367
MET A 362
 None
 0.80A 5ikrB-3dzuA:
0.9		 5ikrB-3dzuA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0s UNCHARACTERIZED
PROTEIN

(Chlorobaculum
tepidum) 		PF05235
(CHAD) 		3 SER A 264
LEU A 354
MET A 281
 None
 0.75A 5ikrB-3e0sA:
0.4		 5ikrB-3e0sA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evk SUPEROXIDE DISMUTASE
[FE]

(Pyrobaculum
aerophilum) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 SER A  91
LEU A  30
MET A  97
 None
 0.76A 5ikrB-3evkA:
undetectable		 5ikrB-3evkA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN

(Homo sapiens) 		PF02820
(MBT) 		3 SER A 335
LEU A 442
MET A 548
 None
 0.86A 5ikrB-3f70A:
undetectable		 5ikrB-3f70A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 SER B 310
LEU B 439
MET B 341
 None
 0.59A 5ikrB-3h1lB:
undetectable		 5ikrB-3h1lB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe) 		PF08389
(Xpo1) 		3 SER T 825
LEU T 862
MET T 866
 None
 0.77A 5ikrB-3icqT:
1.6		 5ikrB-3icqT:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3in5 DNA POLYMERASE KAPPA

(Homo sapiens) 		PF00817
(IMS)
PF11798
(IMS_HHH)
PF11799
(IMS_C) 		3 SER A 423
LEU A 438
MET A 509
 None
 0.84A 5ikrB-3in5A:
undetectable		 5ikrB-3in5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9f POLIOVIRUS RECEPTOR

(Homo sapiens) 		PF07686
(V-set) 		3 SER 7 107
LEU 7 113
MET 7 110
 NAG  7 401 ( 3.7A)
None
None
 0.84A 5ikrB-3j9f7:
undetectable		 5ikrB-3j9f7:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb4 VP1

(Parechovirus B) 		no annotation 3 SER A 165
LEU A 179
MET A 169
 None
 0.85A 5ikrB-3jb4A:
undetectable		 5ikrB-3jb4A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jru PROBABLE CYTOSOL
AMINOPEPTIDASE

(Xanthomonas
oryzae) 		no annotation 3 SER B 332
LEU B 243
MET B 222
 None
 0.83A 5ikrB-3jruB:
undetectable		 5ikrB-3jruB:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juu PORPHYRANASE B

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		3 SER A 136
LEU A 231
MET A 180
 None
 0.71A 5ikrB-3juuA:
undetectable		 5ikrB-3juuA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k60 HEAT SHOCK PROTEIN
86

(Plasmodium
falciparum) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 SER A  80
LEU A  89
MET A  84
 None
None
ADP  A 400 (-3.6A)
 0.87A 5ikrB-3k60A:
undetectable		 5ikrB-3k60A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kky SUPEROXIDE DISMUTASE
[MN]

(Deinococcus
radiodurans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 SER A  81
LEU A  14
MET A  87
 None
 0.80A 5ikrB-3kkyA:
undetectable		 5ikrB-3kkyA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Saccharomyces
cerevisiae) 		no annotation 3 SER B 247
LEU B 105
MET B 112
 None
 0.83A 5ikrB-3kx2B:
undetectable		 5ikrB-3kx2B:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3led 3-OXOACYL-ACYL
CARRIER PROTEIN
SYNTHASE III

(Rhodopseudomonas
palustris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		3 SER A 356
LEU A 290
MET A 293
 None
 0.66A 5ikrB-3ledA:
undetectable		 5ikrB-3ledA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm8 THIAMINE
PYROPHOSPHOKINASE

(Bacillus
subtilis) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		3 SER A 156
LEU A 117
MET A 138
 None
 0.84A 5ikrB-3lm8A:
undetectable		 5ikrB-3lm8A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nlc UNCHARACTERIZED
PROTEIN VP0956

(Vibrio
parahaemolyticus) 		no annotation 3 SER A 249
LEU A 274
MET A 273
 None
 0.86A 5ikrB-3nlcA:
undetectable		 5ikrB-3nlcA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxh TRANSCRIPTIONAL
REGULATOR YVHJ

(Bacillus
subtilis) 		PF03816
(LytR_cpsA_psr) 		3 SER A 140
LEU A  80
MET A  82
 None
 0.85A 5ikrB-3nxhA:
undetectable		 5ikrB-3nxhA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p52 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Campylobacter
jejuni) 		PF02540
(NAD_synthase) 		3 SER A  87
LEU A  54
MET A  56
 None
None
NO3  A 247 (-4.6A)
 0.76A 5ikrB-3p52A:
undetectable		 5ikrB-3p52A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pic CIP2

(Trichoderma
reesei) 		no annotation 3 SER A 278
LEU A 357
MET A 285
 None
 0.85A 5ikrB-3picA:
undetectable		 5ikrB-3picA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rp7 FLAVOPROTEIN
MONOOXYGENASE

(Klebsiella
pneumoniae) 		PF01494
(FAD_binding_3) 		3 SER A 146
LEU A  -5
MET A   1
 None
 0.62A 5ikrB-3rp7A:
undetectable		 5ikrB-3rp7A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ru8 EPITOPE SCAFFOLD
2BODX43

(Human
immunodeficiency
virus;
Thermobifida
fusca;
synthetic
construct) 		PF01341
(Glyco_hydro_6) 		3 SER X 148
LEU X 160
MET X 156
 None
None
GOL  X 283 (-4.4A)
 0.77A 5ikrB-3ru8X:
undetectable		 5ikrB-3ru8X:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3smt HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3

(Homo sapiens) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		3 SER A 345
LEU A 394
MET A 351
 None
None
UNX  A 509 ( 4.4A)
 0.88A 5ikrB-3smtA:
undetectable		 5ikrB-3smtA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uwd PHOSPHOGLYCERATE
KINASE

(Bacillus
anthracis) 		PF00162
(PGK) 		3 SER A 370
LEU A 338
MET A 366
 None
 0.85A 5ikrB-3uwdA:
undetectable		 5ikrB-3uwdA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvu PROTEIN KINASE OSPG

(Shigella
flexneri) 		no annotation 3 SER A 152
LEU A 139
MET A 144
 None
 0.72A 5ikrB-4bvuA:
undetectable		 5ikrB-4bvuA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hf5 FAB 8F8 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H  21
LEU H  82
MET H  82
 None
 0.86A 5ikrB-4hf5H:
undetectable		 5ikrB-4hf5H:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4js1 BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1

(Homo sapiens) 		PF00777
(Glyco_transf_29) 		3 SER A 151
LEU A 209
MET A 331
 None
 0.72A 5ikrB-4js1A:
undetectable		 5ikrB-4js1A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxu PUTATIVE
AMINOTRANSFERASE

(Sinorhizobium
meliloti) 		PF01063
(Aminotran_4) 		3 SER A 238
LEU A 141
MET A 241
 None
 0.79A 5ikrB-4jxuA:
undetectable		 5ikrB-4jxuA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nxr T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 1

(Homo sapiens) 		PF00595
(PDZ) 		3 SER A 919
LEU A 906
MET A 911
 None
 0.77A 5ikrB-4nxrA:
undetectable		 5ikrB-4nxrA:
12.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		3 SER A 354
LEU A 385
MET A 523
 None
 0.15A 5ikrB-4ph9A:
62.8		 5ikrB-4ph9A:
88.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uok FAB FRAGMENT HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER A 317
LEU A 263
MET A 255
 None
 0.70A 5ikrB-4uokA:
undetectable		 5ikrB-4uokA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6w NBFEDF6

(Lama glama) 		PF07686
(V-set) 		3 SER B 854
LEU B 878
MET B 834
 None
 0.86A 5ikrB-4w6wB:
undetectable		 5ikrB-4w6wB:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeb GLUCANASE

(Talaromyces
funiculosus) 		PF00840
(Glyco_hydro_7) 		3 SER A 331
LEU A 210
MET A 356
 None
 0.80A 5ikrB-4xebA:
undetectable		 5ikrB-4xebA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Sus scrofa) 		PF00202
(Aminotran_3) 		3 SER A  73
LEU A 364
MET A 332
 None
 0.86A 5ikrB-4y0iA:
undetectable		 5ikrB-4y0iA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a35 GLYCINE CLEAVAGE
SYSTEM H PROTEIN

(Streptococcus
pyogenes) 		PF01597
(GCV_H) 		3 SER A  63
LEU A  83
MET A  21
 None
 0.76A 5ikrB-5a35A:
undetectable		 5ikrB-5a35A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a89 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF

(Corynebacterium
ammoniagenes) 		PF01687
(Flavokinase) 		3 SER A 269
LEU A 303
MET A 307
 None
FMN  A 339 (-4.9A)
FMN  A 339 (-4.3A)
 0.85A 5ikrB-5a89A:
undetectable		 5ikrB-5a89A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 SER A 416
LEU A 405
MET A 413
 None
 0.79A 5ikrB-5ahkA:
undetectable		 5ikrB-5ahkA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cs0 ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		3 SER A 848
LEU A 881
MET A 862
 None
 0.84A 5ikrB-5cs0A:
undetectable		 5ikrB-5cs0A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		3 SER A 848
LEU A 881
MET A 862
 None
 0.85A 5ikrB-5cslA:
undetectable		 5ikrB-5cslA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5da0 NANOBODY

(Lama glama) 		PF07686
(V-set) 		3 SER B  24
LEU B  89
MET B  86
 None
 0.84A 5ikrB-5da0B:
undetectable		 5ikrB-5da0B:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11

(Methanocaldococcus
jannaschii) 		PF00149
(Metallophos) 		3 SER A 180
LEU A 107
MET A 156
 None
 0.75A 5ikrB-5dnyA:
undetectable		 5ikrB-5dnyA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e02 FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		3 SER A 264
LEU A 273
MET A 268
 None
 0.85A 5ikrB-5e02A:
undetectable		 5ikrB-5e02A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehk LANTIBIOTIC
DEHYDRATASE

(Microbispora
corallina) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		3 SER A 231
LEU A 272
MET A 276
 None
 0.80A 5ikrB-5ehkA:
undetectable		 5ikrB-5ehkA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eks 3-DEHYDROQUINATE
SYNTHASE

(Acinetobacter
baumannii) 		PF01761
(DHQ_synthase) 		3 SER A 304
LEU A 189
MET A 271
 None
 0.82A 5ikrB-5eksA:
undetectable		 5ikrB-5eksA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9w HEAVY CHAIN OF
CH235-LINEAGE
ANTIBODY CH235

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B  21
LEU B  82
MET B  82
 None
 0.83A 5ikrB-5f9wB:
undetectable		 5ikrB-5f9wB:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2

(Arabidopsis
thaliana) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		3 SER A 416
LEU A 369
MET A 465
 FAD  A 802 (-3.1A)
None
None
 0.83A 5ikrB-5gxuA:
undetectable		 5ikrB-5gxuA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsb RNA POLYMERASE

(Andes
orthohantavirus) 		no annotation 3 SER A  90
LEU A 138
MET A  74
 None
 0.67A 5ikrB-5hsbA:
undetectable		 5ikrB-5hsbA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltq GREEN FLUORESCENT
PROTEIN BLFP-Y3

(Branchiostoma
lanceolatum) 		PF01353
(GFP) 		3 SER A  14
LEU A  39
MET A  22
 None
 0.82A 5ikrB-5ltqA:
undetectable		 5ikrB-5ltqA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m38 OMPA FAMILY PROTEIN

(Escherichia
coli) 		no annotation 3 SER A  80
LEU A  30
MET A  71
 None
 0.79A 5ikrB-5m38A:
undetectable		 5ikrB-5m38A:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT

(Escherichia
coli) 		PF03814
(KdpA) 		3 SER A 378
LEU A  63
MET A 501
 None
 0.72A 5ikrB-5mrwA:
1.5		 5ikrB-5mrwA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC

(synthetic
construct) 		no annotation 3 SER D  24
LEU D  49
MET D  32
 None
 0.83A 5ikrB-5mwcD:
undetectable		 5ikrB-5mwcD:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4

(Homo sapiens) 		no annotation 3 SER A 473
LEU A 502
MET A 515
 None
 0.86A 5ikrB-5nqaA:
undetectable		 5ikrB-5nqaA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3

(Homo sapiens) 		PF02469
(Fasciclin) 		3 SER A 516
LEU A 531
MET A 506
 None
 0.81A 5ikrB-5nv6A:
undetectable		 5ikrB-5nv6A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogl UNDECAPRENYL-DIPHOSP
HOOLIGOSACCHARIDE--P
ROTEIN
GLYCOTRANSFERASE

(Campylobacter
lari) 		no annotation 3 SER A 538
LEU A 510
MET A 530
 None
 0.85A 5ikrB-5oglA:
undetectable		 5ikrB-5oglA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Synechocystis
sp. PCC 6803) 		no annotation 3 SER b   9
LEU b  42
MET b  37
 None
 0.77A 5ikrB-5oy0b:
undetectable		 5ikrB-5oy0b:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc1 MATURATION PROTEIN

(Escherichia
virus MS2) 		PF03863
(Phage_mat-A) 		3 SER M 376
LEU M 275
MET M 306
 None
 0.87A 5ikrB-5tc1M:
undetectable		 5ikrB-5tc1M:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v72 NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE

(Sinorhizobium
meliloti) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 SER A  63
LEU A  53
MET A  58
 None
 0.88A 5ikrB-5v72A:
undetectable		 5ikrB-5v72A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w76 ANCESTRAL ELOGATION
FACTOR N153

(synthetic
construct) 		no annotation 3 SER A  64
LEU A 122
MET A  92
 None
 0.76A 5ikrB-5w76A:
undetectable		 5ikrB-5w76A:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y79 PUTATIVE HEXOSE
PHOSPHATE
TRANSLOCATOR

(Galdieria
sulphuraria) 		PF03151
(TPT) 		3 SER A 193
LEU A 325
MET A 133
 None
 0.87A 5ikrB-5y79A:
undetectable		 5ikrB-5y79A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfu SPIKE PROTEIN

(Coronavirus
HKU15) 		no annotation 3 SER A 383
LEU A 356
MET A 388
 None
 0.79A 5ikrB-6bfuA:
undetectable		 5ikrB-6bfuA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)

(Homo sapiens) 		no annotation 3 SER A1622
LEU A1860
MET A2041
 None
 0.68A 5ikrB-6bq1A:
undetectable		 5ikrB-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bsp U4 HEAVY CHAIN

(Mus musculus) 		no annotation 3 SER A  21
LEU A  82
MET A  82
 None
 0.76A 5ikrB-6bspA:
undetectable		 5ikrB-6bspA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnu METHYLENETETRAHYDROF
OLATE REDUCTASE 1

(Saccharomyces
cerevisiae) 		no annotation 3 SER A  16
LEU A  31
MET A  35
 None
 0.77A 5ikrB-6fnuA:
undetectable		 5ikrB-6fnuA:
9.44