SIMILAR PATTERNS OF AMINO ACIDS FOR 5IKR_A_ID8A601_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsl BACTERIAL LUCIFERASE

(Vibrio harveyi) 		PF00296
(Bac_luciferase) 		3 VAL A 285
LEU A 247
MET A 264
 None
 0.81A 5ikrA-1bslA:
undetectable		 5ikrA-1bslA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea9 CYCLOMALTODEXTRINASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		3 VAL C 530
LEU C 425
MET C 436
 None
 0.85A 5ikrA-1ea9C:
0.0		 5ikrA-1ea9C:
22.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		3 VAL A 116
LEU A 384
MET A 522
 None
 0.42A 5ikrA-1ebvA:
58.6		 5ikrA-1ebvA:
63.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn9 OUTER-CAPSID PROTEIN
SIGMA 3

(Reovirus sp.) 		PF00979
(Reovirus_cap) 		3 VAL A 302
LEU A  68
MET A  42
 None
 0.45A 5ikrA-1fn9A:
0.0		 5ikrA-1fn9A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjq BETA-1,4-GALACTANASE

(Humicola
insolens) 		PF07745
(Glyco_hydro_53) 		3 VAL A 164
LEU A 196
MET A 203
 None
 0.87A 5ikrA-1hjqA:
0.0		 5ikrA-1hjqA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1o REPLICATION PROTEIN
A 32 KDA SUBUNIT
REPLICATION PROTEIN
A 70 KDA DNA-BINDING
SUBUNIT

(Homo sapiens) 		PF08646
(Rep_fac-A_C)
no annotation 		3 VAL C 607
LEU B 149
MET B 152
 None
 0.66A 5ikrA-1l1oC:
0.0		 5ikrA-1l1oC:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		3 VAL A 250
LEU A 238
MET A 239
 None
HEM  A1407 (-4.6A)
HEM  A1407 (-3.6A)
 0.85A 5ikrA-1odoA:
0.0		 5ikrA-1odoA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poi GLUTACONATE COENZYME
A-TRANSFERASE

(Acidaminococcus
fermentans) 		PF01144
(CoA_trans) 		3 VAL A 173
LEU A  96
MET A  98
 None
 0.90A 5ikrA-1poiA:
0.0		 5ikrA-1poiA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Rhodospirillum
rubrum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		3 VAL A 310
LEU A 255
MET A 280
 None
 0.84A 5ikrA-1ptjA:
undetectable		 5ikrA-1ptjA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli) 		PF00161
(RIP) 		3 VAL A 120
LEU A  67
MET A 143
 FMT  A3010 (-4.5A)
None
None
 0.90A 5ikrA-1r4pA:
undetectable		 5ikrA-1r4pA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 VAL A 608
LEU A 486
MET A 483
 None
 0.77A 5ikrA-1r9jA:
undetectable		 5ikrA-1r9jA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqj GERANYLTRANSTRANSFER
ASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		3 VAL A 154
LEU A 303
MET A  79
 None
 0.61A 5ikrA-1rqjA:
undetectable		 5ikrA-1rqjA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5r LUKS-PV

(Staphylococcus
phage PVL) 		PF07968
(Leukocidin) 		3 VAL A 103
LEU A 177
MET A 170
 None
 0.79A 5ikrA-1t5rA:
undetectable		 5ikrA-1t5rA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6z EXOPOLYPHOSPHATASE

(Escherichia
coli) 		PF02541
(Ppx-GppA) 		3 VAL A  16
LEU A  57
MET A  62
 None
 0.73A 5ikrA-1u6zA:
undetectable		 5ikrA-1u6zA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ued P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		3 VAL A 404
LEU A 289
MET A 253
 None
None
HEM  A1430 (-4.6A)
 0.83A 5ikrA-1uedA:
undetectable		 5ikrA-1uedA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		3 VAL A 410
LEU A 711
MET A 318
 None
 0.69A 5ikrA-1urjA:
undetectable		 5ikrA-1urjA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkx PROTEIN (NF-KAPPA B
P50 SUBUNIT)

(Mus musculus) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		3 VAL B 533
LEU B 451
MET B 455
 None
 0.81A 5ikrA-1vkxB:
undetectable		 5ikrA-1vkxB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wfx PROBABLE RNA
2'-PHOSPHOTRANSFERAS
E

(Aeropyrum
pernix) 		PF01885
(PTS_2-RNA) 		3 VAL A 166
LEU A 103
MET A 107
 None
 0.88A 5ikrA-1wfxA:
undetectable		 5ikrA-1wfxA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmr ISOPULLULANASE

(Aspergillus
niger) 		PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N) 		3 VAL A 249
LEU A 355
MET A 325
 None
 0.63A 5ikrA-1wmrA:
undetectable		 5ikrA-1wmrA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuu GALACTOKINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		3 VAL A 133
LEU A 325
MET A 343
 None
 0.82A 5ikrA-1wuuA:
0.8		 5ikrA-1wuuA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdp POLYPHOSPHATE KINASE

(Escherichia
coli) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		3 VAL A 586
LEU A  98
MET A  36
 None
 0.73A 5ikrA-1xdpA:
undetectable		 5ikrA-1xdpA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1

(Homo sapiens) 		PF00619
(CARD)
PF00931
(NB-ARC) 		3 VAL A 124
LEU A 306
MET A 301
 None
 0.87A 5ikrA-1z6tA:
undetectable		 5ikrA-1z6tA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcw AROMATIC
PRENYLTRANSFERASE

(Streptomyces
sp. CL190) 		PF11468
(PTase_Orf2) 		3 VAL A  49
LEU A  95
MET A 165
 None
 0.65A 5ikrA-1zcwA:
undetectable		 5ikrA-1zcwA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 VAL A 168
LEU A  69
MET A  80
 None
 0.78A 5ikrA-1zpuA:
undetectable		 5ikrA-1zpuA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b87 ANTI-ZTAQ AFFIBODY
ZTAQ AFFIBODY

(Staphylococcus
aureus) 		PF02216
(B) 		3 VAL A   1
LEU A  34
MET B  17
 None
 0.85A 5ikrA-2b87A:
undetectable		 5ikrA-2b87A:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		3 VAL A 196
LEU A 136
MET A 153
 None
 0.62A 5ikrA-2dylA:
undetectable		 5ikrA-2dylA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5f HYPOTHETICAL PROTEIN
PH0510

(Pyrococcus
horikoshii) 		PF01380
(SIS) 		3 VAL A  24
LEU A  99
MET A 119
 None
 0.86A 5ikrA-2e5fA:
undetectable		 5ikrA-2e5fA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7q MCMV TEGUMENT
PROTEIN M48 ENCODED
UBIQUITIN- SPECIFIC
PROTEASE, M48USP

(Murid
betaherpesvirus
1) 		PF04843
(Herpes_teg_N) 		3 VAL A 132
LEU A 214
MET A 218
 None
 0.80A 5ikrA-2j7qA:
undetectable		 5ikrA-2j7qA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phl PHASEOLIN

(Phaseolus
vulgaris) 		PF00190
(Cupin_1) 		3 VAL A 253
LEU A 354
MET A 366
 None
 0.83A 5ikrA-2phlA:
undetectable		 5ikrA-2phlA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE

(Agrobacterium
fabrum) 		PF03562
(MltA)
PF06725
(3D) 		3 VAL A  10
LEU A 285
MET A 318
 None
 0.86A 5ikrA-2pnwA:
undetectable		 5ikrA-2pnwA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		3 VAL A 290
LEU A 311
MET A 284
 None
 0.83A 5ikrA-2pqdA:
undetectable		 5ikrA-2pqdA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdx FERREDOXIN REDUCTASE

(Pseudomonas
aeruginosa) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 VAL A 144
LEU A  99
MET A 217
 None
 0.90A 5ikrA-2qdxA:
undetectable		 5ikrA-2qdxA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6e PROTELEMORASE

(Klebsiella
phage phiKO2) 		PF16684
(Telomere_res) 		3 VAL A 378
LEU A 328
MET A 261
 None
 0.86A 5ikrA-2v6eA:
undetectable		 5ikrA-2v6eA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF13416
(SBP_bac_8) 		3 VAL A 354
LEU A  62
MET A 330
 None
 0.86A 5ikrA-2w7yA:
undetectable		 5ikrA-2w7yA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus) 		PF00067
(p450) 		3 VAL A 404
LEU A 288
MET A 252
 None
 0.85A 5ikrA-2zbzA:
undetectable		 5ikrA-2zbzA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsj THREONINE SYNTHASE

(Aquifex
aeolicus) 		PF00291
(PALP) 		3 VAL A 152
LEU A 119
MET A 123
 None
 0.89A 5ikrA-2zsjA:
0.0		 5ikrA-2zsjA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN

(Thermosynechococcus
vulcanus) 		PF00421
(PSII) 		3 VAL B  96
LEU B 158
MET B 166
 CLA  B1013 (-4.9A)
None
None
 0.90A 5ikrA-3a0hB:
undetectable		 5ikrA-3a0hB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2b SERINE
PALMITOYLTRANSFERASE

(Sphingobacterium
multivorum) 		PF00155
(Aminotran_1_2) 		3 VAL A 270
LEU A 177
MET A 125
 None
 0.88A 5ikrA-3a2bA:
undetectable		 5ikrA-3a2bA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cin MYO-INOSITOL-1-PHOSP
HATE
SYNTHASE-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		3 VAL A 182
LEU A  95
MET A 243
 None
 0.84A 5ikrA-3cinA:
0.0		 5ikrA-3cinA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dde TENA/THI-4 PROTEIN,
DOMAIN OF UNKNOWN
FUNCTION WITH A HEME
OXYGENASE-LIKE FOLD

(Shewanella
denitrificans) 		PF14518
(Haem_oxygenas_2) 		3 VAL A 104
LEU A 159
MET A 164
 None
 0.86A 5ikrA-3ddeA:
0.1		 5ikrA-3ddeA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fym PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF13413
(HTH_25) 		3 VAL A1060
LEU A1044
MET A1032
 None
None
ZN  A2001 ( 4.8A)
 0.79A 5ikrA-3fymA:
undetectable		 5ikrA-3fymA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs6 BETA-HEXOSAMINIDASE

(Vibrio cholerae) 		PF00933
(Glyco_hydro_3) 		3 VAL A  68
LEU A 200
MET A 203
 None
 0.86A 5ikrA-3gs6A:
undetectable		 5ikrA-3gs6A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 VAL B1151
LEU A 346
MET A1435
 None
 0.68A 5ikrA-3h0gB:
undetectable		 5ikrA-3h0gB:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbc CHOLOYLGLYCINE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF02275
(CBAH) 		3 VAL A  38
LEU A 104
MET A 197
 None
 0.89A 5ikrA-3hbcA:
undetectable		 5ikrA-3hbcA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 2

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 VAL A 539
LEU A 595
MET A 534
 None
 0.79A 5ikrA-3hhsA:
undetectable		 5ikrA-3hhsA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig3 PLXNA3 PROTEIN

(Mus musculus) 		PF08337
(Plexin_cytopl) 		3 VAL A1560
LEU A1576
MET A1530
 None
 0.85A 5ikrA-3ig3A:
0.7		 5ikrA-3ig3A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jys SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 VAL A 515
LEU A 229
MET A 233
 None
 0.89A 5ikrA-3jysA:
undetectable		 5ikrA-3jysA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldh LACTATE
DEHYDROGENASE

(Squalus
acanthias) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 VAL A 271
LEU A  45
MET A 262
 None
 0.90A 5ikrA-3ldhA:
undetectable		 5ikrA-3ldhA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loy COPPER AMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid) 		3 VAL A 588
LEU A  49
MET A  45
 None
 0.78A 5ikrA-3loyA:
undetectable		 5ikrA-3loyA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwb D-ALANINE--D-ALANINE
LIGASE

(Mycobacterium
tuberculosis) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 VAL A  11
LEU A 243
MET A 245
 None
 0.90A 5ikrA-3lwbA:
undetectable		 5ikrA-3lwbA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE

(Rhodobacter
capsulatus) 		PF00590
(TP_methylase) 		3 VAL A  52
LEU A  84
MET A  90
 None
 0.60A 5ikrA-3ndcA:
undetectable		 5ikrA-3ndcA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		3 VAL A1130
LEU A1114
MET A1119
 None
 0.72A 5ikrA-3pieA:
undetectable		 5ikrA-3pieA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qit POLYKETIDE SYNTHASE

(Moorea
producens) 		PF00561
(Abhydrolase_1) 		3 VAL A  85
LEU A 213
MET A 104
 None
 0.89A 5ikrA-3qitA:
undetectable		 5ikrA-3qitA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se4 INTERFERON OMEGA-1

(Homo sapiens) 		PF00143
(Interferon) 		3 VAL B  58
LEU B  20
MET B 151
 None
 0.88A 5ikrA-3se4B:
undetectable		 5ikrA-3se4B:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		3 VAL A 124
LEU A 306
MET A 301
 None
 0.73A 5ikrA-3sfzA:
undetectable		 5ikrA-3sfzA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF00275
(EPSP_synthase) 		3 VAL A 215
LEU A 228
MET A 209
 None
 0.86A 5ikrA-3swgA:
undetectable		 5ikrA-3swgA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		3 VAL A  92
LEU A   7
MET A  33
 None
 0.86A 5ikrA-3swxA:
undetectable		 5ikrA-3swxA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Coxiella
burnetii) 		PF00275
(EPSP_synthase) 		3 VAL A  65
LEU A  82
MET A  59
 None
 0.64A 5ikrA-3tr1A:
0.3		 5ikrA-3tr1A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Coxiella
burnetii) 		PF00275
(EPSP_synthase) 		3 VAL A 279
LEU A 300
MET A 273
 None
 0.80A 5ikrA-3tr1A:
0.3		 5ikrA-3tr1A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE

(Conticribra
weissflogii) 		no annotation 3 VAL A 617
LEU A 462
MET A 592
 None
 0.78A 5ikrA-3uk8A:
undetectable		 5ikrA-3uk8A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ajv TRANSFORMING GROWTH
FACTOR BETA RECEPTOR
TYPE 3

(Mus musculus) 		PF00100
(Zona_pellucida) 		3 VAL A 673
LEU A 750
MET A 594
 None
 0.88A 5ikrA-4ajvA:
undetectable		 5ikrA-4ajvA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnk L-AMINO ACID OXIDASE

(Streptococcus
cristatus) 		PF03486
(HI0933_like) 		3 VAL A  75
LEU A 117
MET A  16
 None
 0.53A 5ikrA-4cnkA:
undetectable		 5ikrA-4cnkA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dka RNA-EDITING COMPLEX
PROTEIN MP81
SINGLE DOMAIN
ANTIBODY VHH

(Lama glama;
Trypanosoma
brucei) 		PF07686
(V-set)
no annotation 		3 VAL C 736
LEU A  81
MET A  83
 None
 0.68A 5ikrA-4dkaC:
undetectable		 5ikrA-4dkaC:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxb PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		3 VAL A 409
LEU A 293
MET A 257
 None
 0.65A 5ikrA-4fxbA:
undetectable		 5ikrA-4fxbA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g41 MTA/SAH NUCLEOSIDASE

(Streptococcus
pyogenes) 		PF01048
(PNP_UDP_1) 		3 VAL A 132
LEU A  84
MET A 195
 VAL  A 132 ( 0.5A)
LEU  A  84 ( 0.6A)
MET  A 195 ( 0.0A)
 0.89A 5ikrA-4g41A:
undetectable		 5ikrA-4g41A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		3 VAL A 488
LEU A 174
MET A 508
 None
 0.88A 5ikrA-4i8vA:
undetectable		 5ikrA-4i8vA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4icq AMINOPEPTIDASE PEPS

(Streptococcus
pneumoniae) 		PF02073
(Peptidase_M29) 		3 VAL A 238
LEU A 370
MET A 365
 None
 0.90A 5ikrA-4icqA:
undetectable		 5ikrA-4icqA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx2 HYPOTHETICAL PROTEIN

(Legionella
pneumophila) 		no annotation 3 VAL A 190
LEU A 420
MET A 263
 None
 0.77A 5ikrA-4jx2A:
undetectable		 5ikrA-4jx2A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqk NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Salmonella
enterica) 		PF02277
(DBI_PRT) 		3 VAL A  58
LEU A  29
MET A 338
 None
 0.90A 5ikrA-4kqkA:
undetectable		 5ikrA-4kqkA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le7 PYOCIN L1

(Pseudomonas
aeruginosa) 		PF01453
(B_lectin) 		3 VAL A  50
LEU A   5
MET A  58
 EDO  A 318 (-4.2A)
None
None
 0.71A 5ikrA-4le7A:
undetectable		 5ikrA-4le7A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le7 PYOCIN L1

(Pseudomonas
aeruginosa) 		PF01453
(B_lectin) 		3 VAL A  50
LEU A  92
MET A  58
 EDO  A 318 (-4.2A)
None
None
 0.78A 5ikrA-4le7A:
undetectable		 5ikrA-4le7A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oon PENICILLIN-BINDING
PROTEIN 1A

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		3 VAL A 715
LEU A 517
MET A 671
 None
 0.87A 5ikrA-4oonA:
undetectable		 5ikrA-4oonA:
21.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		3 VAL A 117
LEU A 385
MET A 523
 BOG  A 604 (-3.9A)
None
None
 0.13A 5ikrA-4ph9A:
63.0		 5ikrA-4ph9A:
88.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqj PHOSPHATE BINDING
PROTEIN

(Pseudomonas
aeruginosa) 		PF12849
(PBP_like_2) 		3 VAL A 205
LEU A 242
MET A 140
 None
 0.82A 5ikrA-4pqjA:
undetectable		 5ikrA-4pqjA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C) 		no annotation 3 VAL A 254
LEU A 348
MET A 379
 None
 0.78A 5ikrA-4qnlA:
undetectable		 5ikrA-4qnlA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uir OLEATE HYDRATASE

(Elizabethkingia
meningoseptica) 		PF06100
(MCRA) 		3 VAL A 571
LEU A 273
MET A  75
 None
 0.90A 5ikrA-4uirA:
undetectable		 5ikrA-4uirA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A

(Homo sapiens) 		PF00069
(Pkinase) 		3 VAL A 352
LEU A 333
MET A 370
 None
 0.88A 5ikrA-4yljA:
undetectable		 5ikrA-4yljA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE

(Bacillus cereus) 		PF05547
(Peptidase_M6) 		3 VAL A 673
LEU A 387
MET A 408
 None
 0.87A 5ikrA-4yu5A:
undetectable		 5ikrA-4yu5A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
aeruginosa) 		PF00275
(EPSP_synthase) 		3 VAL A 140
LEU A 154
MET A 134
 None
 0.89A 5ikrA-5bq2A:
undetectable		 5ikrA-5bq2A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bs5 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		3 VAL A 384
LEU A 394
MET A 372
 None
 0.66A 5ikrA-5bs5A:
undetectable		 5ikrA-5bs5A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex6 CYTOCHROME P450

(Streptomyces
toyocaensis) 		no annotation 3 VAL C 396
LEU C 280
MET C 244
 None
 0.73A 5ikrA-5ex6C:
undetectable		 5ikrA-5ex6C:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fac ALANINE RACEMASE

(Streptomyces
coelicolor) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 VAL A 108
LEU A 160
MET A 119
 None
 0.89A 5ikrA-5facA:
undetectable		 5ikrA-5facA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA

(Lactobacillus
plantarum) 		PF09861
(DUF2088) 		3 VAL A 240
LEU A 233
MET A 255
 None
 0.65A 5ikrA-5huqA:
undetectable		 5ikrA-5huqA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it1 PUTATIVE CYTOCHROME
P450

(Streptomyces
peucetius) 		PF00067
(p450) 		3 VAL A 397
LEU A 281
MET A 245
 None
None
HEM  A 401 ( 4.4A)
 0.83A 5ikrA-5it1A:
undetectable		 5ikrA-5it1A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j90 RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12741
(SusD-like) 		3 VAL A 268
LEU A 140
MET A  54
 None
 0.58A 5ikrA-5j90A:
undetectable		 5ikrA-5j90A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jab BILIVERDIN REDUCTASE
RV2074

(Mycobacterium
tuberculosis) 		PF01243
(Putative_PNPOx) 		3 VAL A 122
LEU A 134
MET A   1
 None
 0.86A 5ikrA-5jabA:
undetectable		 5ikrA-5jabA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 VAL A 348
LEU A 282
MET A 271
 None
 0.86A 5ikrA-5l6fA:
undetectable		 5ikrA-5l6fA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT

(Clostridioides
difficile) 		no annotation 3 VAL A  18
LEU A 132
MET A 134
 None
 0.87A 5ikrA-5ol2A:
undetectable		 5ikrA-5ol2A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tlq THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA

(Pseudomonas
aeruginosa) 		PF01323
(DSBA) 		3 VAL A  19
LEU A  79
MET A 138
 None
1YO  A 201 ( 3.8A)
None
 0.69A 5ikrA-5tlqA:
undetectable		 5ikrA-5tlqA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0s RNA POLYMERASE II
SUBUNIT RPB6

(Schizosaccharomyces
pombe) 		PF04934
(Med6) 		3 VAL f 124
LEU f 108
MET f 112
 None
 0.87A 5ikrA-5u0sf:
undetectable		 5ikrA-5u0sf:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA

(Chaetomium
thermophilum) 		no annotation 3 VAL B 199
LEU B 463
MET B 402
 None
 0.80A 5ikrA-5wfcB:
undetectable		 5ikrA-5wfcB:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu7 UNCHARACTERIZED
PROTEIN

(Pyrococcus
horikoshii) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		3 VAL A 140
LEU A  29
MET A  33
 None
 0.73A 5ikrA-5wu7A:
undetectable		 5ikrA-5wu7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1

(Homo sapiens) 		PF00400
(WD40)
PF00931
(NB-ARC) 		3 VAL A 124
LEU A 306
MET A 301
 None
 0.72A 5ikrA-5wveA:
undetectable		 5ikrA-5wveA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgu RIBONUCLEASE R

(Escherichia
coli) 		no annotation 3 VAL B 237
LEU B 128
MET B 136
 None
 0.85A 5ikrA-5xguB:
undetectable		 5ikrA-5xguB:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysm CYTOCHROME P450

(Amycolatopsis
mediterranei) 		no annotation 3 VAL A 390
LEU A 300
MET A 264
 None
None
HEM  A 501 (-4.8A)
 0.77A 5ikrA-5ysmA:
undetectable		 5ikrA-5ysmA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blb HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB

(Pseudomonas
aeruginosa) 		no annotation 3 VAL A  82
LEU A 127
MET A 131
 None
 0.81A 5ikrA-6blbA:
undetectable		 5ikrA-6blbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
putida) 		no annotation 3 VAL A 140
LEU A 154
MET A 134
 None
 0.78A 5ikrA-6cn1A:
undetectable		 5ikrA-6cn1A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 3 VAL A1171
LEU A1043
MET A1113
 None
 0.81A 5ikrA-6fikA:
undetectable		 5ikrA-6fikA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsh OXYB PROTEIN

(Actinoplanes
teichomyceticus) 		no annotation 3 VAL A 396
LEU A 280
MET A 244
 None
 0.69A 5ikrA-6fshA:
undetectable		 5ikrA-6fshA:
9.21