SIMILAR PATTERNS OF AMINO ACIDS FOR 5IKQ_B_JMSB602
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b3b | PROTEIN (GLUTAMATEDEHYDROGENASE) (Thermotogamaritima) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | VAL A 95LEU A 370VAL A 345GLY A 343ALA A 342 | None | 1.02A | 5ikqB-1b3bA:0.0 | 5ikqB-1b3bA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bvu | PROTEIN (GLUTAMATEDEHYDROGENASE) (Thermococcuslitoralis) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | VAL A 95LEU A 372VAL A 347GLY A 345ALA A 344 | None | 0.96A | 5ikqB-1bvuA:undetectable | 5ikqB-1bvuA:20.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ebv | PROSTAGLANDIN H2SYNTHASE (Ovis aries) |
PF00008(EGF)PF03098(An_peroxidase) | 10 | ARG A 120VAL A 349LEU A 352TYR A 355LEU A 384TYR A 385TRP A 387GLY A 526ALA A 527LEU A 531 | SCL A 700 (-3.9A)SCL A 700 ( 4.6A)SCL A 700 ( 4.8A)SCL A 700 (-4.3A)NoneNoneNoneSCL A 700 ( 4.0A)SCL A 700 (-2.9A)OAS A 530 (-4.1A) | 0.48A | 5ikqB-1ebvA:33.8 | 5ikqB-1ebvA:63.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1euz | GLUTAMATEDEHYDROGENASE (Thermococcusprofundus) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | VAL A 96LEU A 373VAL A 348GLY A 346ALA A 345 | NoneNoneSO4 A 601 (-3.8A)NoneNone | 1.12A | 5ikqB-1euzA:0.4 | 5ikqB-1euzA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gtm | GLUTAMATEDEHYDROGENASE (Pyrococcusfuriosus) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | VAL A 95LEU A 373VAL A 348GLY A 346ALA A 345 | None | 1.01A | 5ikqB-1gtmA:undetectable | 5ikqB-1gtmA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h4l | CELL DIVISIONPROTEIN KINASE 5 (Homo sapiens) |
PF00069(Pkinase) | 5 | LEU A 267GLY A 189ALA A 188SER A 187LEU A 127 | None | 0.93A | 5ikqB-1h4lA:undetectable | 5ikqB-1h4lA:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1htt | HISTIDYL-TRNASYNTHETASE (Escherichiacoli) |
PF03129(HGTP_anticodon)PF13393(tRNA-synt_His) | 5 | LEU A 43TYR A 107GLY A 87ALA A 86LEU A 291 | None | 0.83A | 5ikqB-1httA:0.0 | 5ikqB-1httA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jgc | BACTERIOFERRITIN (Rhodobactercapsulatus) |
PF00210(Ferritin) | 5 | VAL A 131LEU A 134TYR A 25GLY A 93LEU A 98 | None | 1.10A | 5ikqB-1jgcA:undetectable | 5ikqB-1jgcA:16.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jy1 | TYROSYL-DNAPHOSPHODIESTERASE (Homo sapiens) |
PF06087(Tyr-DNA_phospho) | 5 | VAL A 227TYR A 537ALA A 332SER A 334LEU A 335 | None | 1.01A | 5ikqB-1jy1A:0.0 | 5ikqB-1jy1A:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l1f | GLUTAMATEDEHYDROGENASE 1 (Homo sapiens) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | VAL A 121LEU A 457VAL A 382GLY A 380ALA A 379 | None | 1.05A | 5ikqB-1l1fA:0.0 | 5ikqB-1l1fA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lzk | HEROIN ESTERASE (Rhodococcus sp.) |
PF07859(Abhydrolase_3) | 5 | LEU A 249VAL A 170GLY A 168ALA A 167LEU A 191 | None | 1.13A | 5ikqB-1lzkA:undetectable | 5ikqB-1lzkA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mgt | PROTEIN(O6-METHYLGUANINE-DNA METHYLTRANSFERASE) (Thermococcuskodakarensis) |
PF01035(DNA_binding_1)PF09153(DUF1938) | 5 | VAL A 138LEU A 43VAL A 18GLY A 26LEU A 84 | None | 1.01A | 5ikqB-1mgtA:undetectable | 5ikqB-1mgtA:13.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pl0 | BIFUNCTIONAL PURINEBIOSYNTHESIS PROTEINPURH (Homo sapiens) |
PF01808(AICARFT_IMPCHas)PF02142(MGS) | 5 | VAL A 99LEU A 8LEU A 68GLY A 127LEU A 132 | NoneNoneXMP A 901 (-4.1A)XMP A 901 (-3.4A)None | 0.98A | 5ikqB-1pl0A:undetectable | 5ikqB-1pl0A:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qhg | ATP-DEPENDENTHELICASE PCRA (Geobacillusstearothermophilus) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 5 | VAL A 40LEU A 41GLY A 250ALA A 31LEU A 282 | None | 1.12A | 5ikqB-1qhgA:undetectable | 5ikqB-1qhgA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1taq | TAQ DNA POLYMERASE (Thermusaquaticus) |
PF00476(DNA_pol_A)PF01367(5_3_exonuc)PF02739(5_3_exonuc_N)PF09281(Taq-exonuc) | 6 | LEU A 30VAL A 44GLY A 46ALA A 48SER A 50LEU A 51 | None | 1.36A | 5ikqB-1taqA:undetectable | 5ikqB-1taqA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tqy | ACTINORHODINPOLYKETIDE PUTATIVEBETA-KETOACYLSYNTHASE 1 (Streptomycescoelicolor) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | LEU A 104GLY A 349ALA A 350SER A 353LEU A 354 | None | 1.14A | 5ikqB-1tqyA:undetectable | 5ikqB-1tqyA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ukc | ESTA (Aspergillusniger) |
PF00135(COesterase) | 6 | VAL A 332LEU A 316VAL A 216GLY A 214ALA A 213SER A 239 | None | 1.48A | 5ikqB-1ukcA:undetectable | 5ikqB-1ukcA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v2d | GLUTAMINEAMINOTRANSFERASE (Thermusthermophilus) |
PF00155(Aminotran_1_2) | 5 | LEU A 51LEU A 43GLY A 262ALA A 261LEU A 63 | None | 1.06A | 5ikqB-1v2dA:undetectable | 5ikqB-1v2dA:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vkn | N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATEREDUCTASE (Thermotogamaritima) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 5 | LEU A 74GLY A 8ALA A 9SER A 34LEU A 55 | None | 0.95A | 5ikqB-1vknA:undetectable | 5ikqB-1vknA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a0u | INITIATION FACTOR 2B (Leishmaniamajor) |
PF01008(IF-2B) | 5 | VAL A 179TYR A 294GLY A 163ALA A 164LEU A 168 | None | 1.10A | 5ikqB-2a0uA:undetectable | 5ikqB-2a0uA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ark | FLAVODOXIN (Aquifexaeolicus) |
PF00258(Flavodoxin_1) | 5 | VAL A 6LEU A 36GLY A 25ALA A 26LEU A 158 | None | 1.04A | 5ikqB-2arkA:undetectable | 5ikqB-2arkA:14.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2elc | ANTHRANILATEPHOSPHORIBOSYLTRANSFERASE (Thermusthermophilus) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N) | 5 | TYR A 238LEU A 74GLY A 290ALA A 289LEU A 223 | None | 0.98A | 5ikqB-2elcA:undetectable | 5ikqB-2elcA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2elc | ANTHRANILATEPHOSPHORIBOSYLTRANSFERASE (Thermusthermophilus) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N) | 5 | TYR A 238LEU A 74GLY A 290ALA A 289LEU A 285 | None | 0.92A | 5ikqB-2elcA:undetectable | 5ikqB-2elcA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2elc | ANTHRANILATEPHOSPHORIBOSYLTRANSFERASE (Thermusthermophilus) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N) | 5 | VAL A 215TYR A 238LEU A 74GLY A 290ALA A 289 | None | 0.81A | 5ikqB-2elcA:undetectable | 5ikqB-2elcA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fiy | PROTEIN FDHE HOMOLOG (Pseudomonasaeruginosa) |
PF04216(FdhE) | 5 | LEU A 125LEU A 140GLY A 157ALA A 158LEU A 55 | None | 1.06A | 5ikqB-2fiyA:undetectable | 5ikqB-2fiyA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ftp | HYDROXYMETHYLGLUTARYL-COA LYASE (Pseudomonasaeruginosa) |
PF00682(HMGL-like) | 5 | VAL A 274LEU A 273GLY A 236ALA A 235SER A 290 | None | 1.08A | 5ikqB-2ftpA:undetectable | 5ikqB-2ftpA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gk9 | PHOSPHATIDYLINOSITOL-4-PHOSPHATE5-KINASE, TYPE II,GAMMA (Homo sapiens) |
PF01504(PIP5K) | 5 | LEU A 126TYR A 189GLY A 54ALA A 56SER A 58 | None | 1.06A | 5ikqB-2gk9A:undetectable | 5ikqB-2gk9A:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hr3 | PROBABLETRANSCRIPTIONALREGULATOR (Pseudomonasaeruginosa) |
PF13463(HTH_27) | 5 | LEU A 104VAL A 39GLY A 42ALA A 43LEU A 47 | None | 1.01A | 5ikqB-2hr3A:undetectable | 5ikqB-2hr3A:14.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j6i | FORMATEDEHYDROGENASE ([Candida]boidinii) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | LEU A 238TYR A 194VAL A 227GLY A 171ALA A 229 | None | 1.07A | 5ikqB-2j6iA:undetectable | 5ikqB-2j6iA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pbl | PUTATIVEESTERASE/LIPASE/THIOESTERASE (Ruegeria sp.TM1040) |
PF07859(Abhydrolase_3) | 5 | TRP A 81GLY A 138ALA A 137SER A 136LEU A 168 | NoneNoneNoneUNL A 263 (-3.7A)None | 1.10A | 5ikqB-2pblA:undetectable | 5ikqB-2pblA:18.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pjr | PROTEIN (HELICASEPCRA) (Geobacillusstearothermophilus) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 5 | VAL A 40LEU A 41GLY A 250ALA A 31LEU A 282 | None | 1.09A | 5ikqB-2pjrA:undetectable | 5ikqB-2pjrA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uwj | TYPE III EXPORTPROTEIN PSCG (Pseudomonasaeruginosa) |
PF09477(Type_III_YscG) | 5 | LEU G 14LEU G 70TRP G 73ALA G 40LEU G 32 | None | 1.03A | 5ikqB-2uwjG:undetectable | 5ikqB-2uwjG:12.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wy0 | ANGIOTENSINOGEN (Mus musculus) |
PF00079(Serpin) | 5 | VAL C 130LEU C 128LEU C 114GLY C 143LEU C 11 | NoneNone NA C1456 ( 4.9A) NA C1456 (-4.0A)None | 1.09A | 5ikqB-2wy0C:undetectable | 5ikqB-2wy0C:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xec | PUTATIVE MALEATEISOMERASE (Nocardiafarcinica) |
no annotation | 5 | LEU A 158VAL A 174ALA A 178SER A 180LEU A 181 | None | 1.03A | 5ikqB-2xecA:undetectable | 5ikqB-2xecA:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xn8 | PUTATIVE CYTOCHROMEP450 125 (Mycobacteriumtuberculosis) |
PF00067(p450) | 5 | VAL A 313LEU A 415VAL A 267GLY A 269ALA A 268 | HEM A1434 ( 4.9A)NoneNoneHEM A1434 (-3.3A)HEM A1434 (-3.5A) | 1.01A | 5ikqB-2xn8A:undetectable | 5ikqB-2xn8A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ylz | PHENYLACETONEMONOOXYGENASE (Thermobifidafusca) |
PF13738(Pyr_redox_3) | 5 | LEU A 146VAL A 21GLY A 23ALA A 149SER A 150 | NoneNoneFAD A 700 (-3.3A)NoneFAD A 700 (-4.9A) | 1.10A | 5ikqB-2ylzA:undetectable | 5ikqB-2ylzA:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ynm | LIGHT-INDEPENDENTPROTOCHLOROPHYLLIDEREDUCTASEIRON-SULFURATP-BINDING PROTEIN (Prochlorococcusmarinus) |
PF00142(Fer4_NifH) | 5 | VAL A 152LEU A 153GLY A 159ALA A 162LEU A 165 | None | 1.06A | 5ikqB-2ynmA:undetectable | 5ikqB-2ynmA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a58 | GTP-BINDING PROTEINRHO1 (Saccharomycescerevisiae) |
PF00071(Ras) | 5 | ARG B 181VAL B 58LEU B 86SER B 183LEU B 184 | None | 1.06A | 5ikqB-3a58B:undetectable | 5ikqB-3a58B:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3at7 | ALGINATE-BINDINGFLAGELLIN (Sphingomonassp. A1) |
PF09375(Peptidase_M75) | 5 | LEU A 87VAL A 158GLY A 160ALA A 162LEU A 165 | None | 1.10A | 5ikqB-3at7A:undetectable | 5ikqB-3at7A:18.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h2s | PUTATIVE NADH-FLAVINREDUCTASE (Lactobacillusparacasei) |
PF13460(NAD_binding_10) | 5 | VAL A 27LEU A 28VAL A 31GLY A 7ALA A 8 | NoneNoneNoneNDP A 301 (-3.2A)None | 1.09A | 5ikqB-3h2sA:undetectable | 5ikqB-3h2sA:16.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l2z | BIRA BIFUNCTIONALPROTEIN (Mycobacteriumtuberculosis) |
PF02237(BPL_C)PF03099(BPL_LplA_LipB) | 5 | LEU A 208LEU A 126GLY A 106ALA A 105LEU A 194 | None | 1.08A | 5ikqB-3l2zA:undetectable | 5ikqB-3l2zA:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l7z | PROBABLE EXOSOMECOMPLEX EXONUCLEASE2 (Sulfolobussolfataricus) |
PF01138(RNase_PH)PF03725(RNase_PH_C) | 5 | LEU A 189LEU A 142VAL A 162ALA A 163LEU A 44 | None | 1.01A | 5ikqB-3l7zA:undetectable | 5ikqB-3l7zA:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3npi | TETR FAMILYREGULATORY PROTEIN (Corynebacteriumdiphtheriae) |
PF00440(TetR_N) | 5 | ARG A 95VAL A 207LEU A 211VAL A 91GLY A 93 | None | 1.06A | 5ikqB-3npiA:undetectable | 5ikqB-3npiA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r5g | CYAB (Pseudomonasaeruginosa) |
PF00211(Guanylate_cyc) | 5 | LEU A 228TYR A 336GLY A 291ALA A 292LEU A 381 | None | 1.08A | 5ikqB-3r5gA:undetectable | 5ikqB-3r5gA:16.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3re2 | PREDICTED PROTEIN (Nematostellavectensis) |
PF05053(Menin) | 5 | VAL A 378LEU A 379GLY A 410SER A 408LEU A 351 | None | 1.01A | 5ikqB-3re2A:undetectable | 5ikqB-3re2A:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u4j | NAD-DEPENDENTALDEHYDEDEHYDROGENASE (Sinorhizobiummeliloti) |
PF00171(Aldedh) | 5 | VAL A 191LEU A 254VAL A 232GLY A 230ALA A 229 | None | 1.13A | 5ikqB-3u4jA:undetectable | 5ikqB-3u4jA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uw2 | PHOSPHOGLUCOMUTASE/PHOSPHOMANNOMUTASEFAMILY PROTEIN (Burkholderiathailandensis) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 5 | TYR A 338TRP A 337VAL A 82ALA A 86LEU A 91 | None | 1.00A | 5ikqB-3uw2A:undetectable | 5ikqB-3uw2A:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w0l | GLUCOKINASEREGULATORY PROTEIN (Xenopus laevis) |
no annotation | 5 | LEU B 49VAL B 488GLY B 491ALA B 492LEU B 323 | None | 1.13A | 5ikqB-3w0lB:3.3 | 5ikqB-3w0lB:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wp5 | CDBFV (Neocallimastixpatriciarum) |
PF00457(Glyco_hydro_11) | 5 | LEU A 59GLY A 204ALA A 203SER A 95LEU A 117 | None | 0.98A | 5ikqB-3wp5A:undetectable | 5ikqB-3wp5A:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wwy | D-LACTATEDEHYDROGENASE (Fusobacteriumnucleatum) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | VAL A 233LEU A 232LEU A 197GLY A 150LEU A 161 | None | 0.99A | 5ikqB-3wwyA:undetectable | 5ikqB-3wwyA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a56 | PULLULANASESECRETION PROTEINPULS (Klebsiellaoxytoca) |
PF09691(T2SS_PulS_OutS) | 5 | LEU A 96VAL A 42GLY A 45ALA A 46LEU A 58 | None | 1.07A | 5ikqB-4a56A:undetectable | 5ikqB-4a56A:11.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4asi | ACETYL-COACARBOXYLASE 1 (Homo sapiens) |
PF01039(Carboxyl_trans) | 5 | LEU A1737GLY A1842ALA A1841SER A1844LEU A1868 | None | 1.10A | 5ikqB-4asiA:undetectable | 5ikqB-4asiA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b0e | F1 CAPSULE-ANCHORINGPROTEIN (Yersinia pestis) |
PF13954(PapC_N) | 5 | VAL A 38LEU A 113LEU A 83ALA A 119LEU A 120 | None | 1.12A | 5ikqB-4b0eA:undetectable | 5ikqB-4b0eA:14.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4boc | DNA-DIRECTED RNAPOLYMERASE,MITOCHONDRIAL (Homo sapiens) |
PF00940(RNA_pol)PF14700(RPOL_N) | 5 | LEU A 297LEU A 234GLY A 270ALA A 272LEU A 280 | None | 1.07A | 5ikqB-4bocA:undetectable | 5ikqB-4bocA:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bxi | ACCESSORY GENEREGULATOR PROTEIN C (Staphylococcusaureus) |
PF14501(HATPase_c_5) | 5 | VAL A 425LEU A 296GLY A 334SER A 332LEU A 400 | None | 1.07A | 5ikqB-4bxiA:undetectable | 5ikqB-4bxiA:13.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4czp | EXTRALONG MANGANESEPEROXIDASE (Gelatoporiasubvermispora) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 5 | VAL A 28VAL A 112GLY A 110ALA A 109LEU A 90 | None | 1.08A | 5ikqB-4czpA:undetectable | 5ikqB-4czpA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4doe | 1,4-BETA-GLUCANASE (Caldicellulosiruptorbescii) |
PF00759(Glyco_hydro_9) | 5 | LEU A 346VAL A 284GLY A 287ALA A 288LEU A 292 | None | 1.12A | 5ikqB-4doeA:undetectable | 5ikqB-4doeA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dwq | TRNA-SPLICING LIGASERTCB (Pyrococcushorikoshii) |
PF01139(RtcB) | 5 | VAL A 147LEU A 148GLY A 191ALA A 192LEU A 139 | None | 1.11A | 5ikqB-4dwqA:undetectable | 5ikqB-4dwqA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h40 | PUTATIVE CELLADHESION PROTEIN (Bacteroidesfragilis) |
PF15415(Mfa_like_2) | 5 | ARG A 79LEU A 98GLY A 119ALA A 144SER A 142 | None | 1.06A | 5ikqB-4h40A:undetectable | 5ikqB-4h40A:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h40 | PUTATIVE CELLADHESION PROTEIN (Bacteroidesfragilis) |
PF15415(Mfa_like_2) | 5 | ARG A 79LEU A 98VAL A 115ALA A 144SER A 142 | None | 1.09A | 5ikqB-4h40A:undetectable | 5ikqB-4h40A:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hhr | ALPHA-DIOXYGENASE (Arabidopsisthaliana) |
PF03098(An_peroxidase) | 5 | VAL A 41LEU A 560TYR A 557VAL A 61LEU A 50 | NoneNoneNoneBNG A 714 ( 4.8A)BNG A 714 ( 4.9A) | 1.13A | 5ikqB-4hhrA:17.0 | 5ikqB-4hhrA:25.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hka | TRYPTOPHAN2,3-DIOXYGENASE (Drosophilamelanogaster) |
PF03301(Trp_dioxygenase) | 5 | VAL A 189LEU A 199GLY A 275ALA A 276LEU A 295 | None | 1.00A | 5ikqB-4hkaA:undetectable | 5ikqB-4hkaA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j9u | TRK SYSTEM POTASSIUMUPTAKE PROTEIN TRKH (Vibrioparahaemolyticus) |
PF02386(TrkH) | 5 | VAL A 79GLY A 81ALA A 83SER A 85LEU A 86 | None | 0.84A | 5ikqB-4j9uA:2.1 | 5ikqB-4j9uA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jgg | ESTERASE TESA (Pseudomonasaeruginosa) |
PF13472(Lipase_GDSL_2) | 5 | LEU A 86LEU A 138VAL A 130GLY A 128ALA A 129 | None | 1.04A | 5ikqB-4jggA:undetectable | 5ikqB-4jggA:16.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lc9 | GLUCOKINASEREGULATORY PROTEIN (Rattusnorvegicus) |
no annotation | 5 | LEU A 53VAL A 489GLY A 492ALA A 493LEU A 497 | None | 1.11A | 5ikqB-4lc9A:2.5 | 5ikqB-4lc9A:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o1m | ENOYL-ACYL CARRIERREDUCTASE (Toxoplasmagondii) |
PF13561(adh_short_C2) | 5 | LEU A 286VAL A 266GLY A 268ALA A 270LEU A 274 | None | 0.87A | 5ikqB-4o1mA:undetectable | 5ikqB-4o1mA:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4peq | RIBONUCLEASE/ANGIOGENIN INHIBITOR 1 (Bos taurus) |
PF13516(LRR_6) | 5 | ARG B 269LEU B 299LEU B 263VAL B 265GLY B 267 | None | 1.04A | 5ikqB-4peqB:undetectable | 5ikqB-4peqB:21.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ph9 | PROSTAGLANDIN G/HSYNTHASE 2 (Mus musculus) |
PF00008(EGF)PF03098(An_peroxidase) | 11 | ARG A 121VAL A 350LEU A 353TYR A 356LEU A 385TYR A 386TRP A 388VAL A 524GLY A 527ALA A 528LEU A 532 | BOG A 604 ( 3.7A)IBP A 601 (-4.3A)IBP A 601 ( 4.7A)IBP A 601 (-4.5A)NoneIBP A 601 (-4.8A)NoneIBP A 601 ( 4.0A)IBP A 601 (-3.9A)IBP A 601 (-3.4A)IBP A 601 ( 4.9A) | 0.32A | 5ikqB-4ph9A:62.9 | 5ikqB-4ph9A:88.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ph9 | PROSTAGLANDIN G/HSYNTHASE 2 (Mus musculus) |
PF00008(EGF)PF03098(An_peroxidase) | 10 | ARG A 121VAL A 350LEU A 353TYR A 356TYR A 386TRP A 388VAL A 524ALA A 528SER A 531LEU A 532 | BOG A 604 ( 3.7A)IBP A 601 (-4.3A)IBP A 601 ( 4.7A)IBP A 601 (-4.5A)IBP A 601 (-4.8A)NoneIBP A 601 ( 4.0A)IBP A 601 (-3.4A)IBP A 601 ( 3.3A)IBP A 601 ( 4.9A) | 0.61A | 5ikqB-4ph9A:62.9 | 5ikqB-4ph9A:88.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pw8 | TRYPTOPHAN2,3-DIOXYGENASE (Homo sapiens) |
PF03301(Trp_dioxygenase) | 5 | VAL A 205LEU A 215GLY A 291ALA A 292LEU A 311 | None | 0.99A | 5ikqB-4pw8A:undetectable | 5ikqB-4pw8A:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r7y | MINICHROMOSOMEMAINTENANCE PROTEINMCM, CELL DIVISIONCONTROL PROTEIN 21 (Pyrococcusfuriosus;Sulfolobussolfataricus) |
PF00493(MCM)PF14551(MCM_N)PF17207(MCM_OB) | 5 | LEU A1871TYR A1874VAL A1283ALA A1301LEU A1302 | None | 1.09A | 5ikqB-4r7yA:1.4 | 5ikqB-4r7yA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r7z | CELL DIVISIONCONTROL PROTEIN 21 (Pyrococcusfuriosus) |
PF00493(MCM) | 5 | LEU A 871TYR A 874VAL A 283ALA A 301LEU A 302 | None | 1.03A | 5ikqB-4r7zA:undetectable | 5ikqB-4r7zA:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ubt | ACETYL-COAACETYLTRANSFERASEFADA5 (Mycobacteriumtuberculosis) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | VAL A 234LEU A 228GLY A 243ALA A 242SER A 245 | NoneNoneCOA A 401 ( 4.3A)COA A 401 (-3.5A)COA A 401 ( 4.0A) | 1.05A | 5ikqB-4ubtA:undetectable | 5ikqB-4ubtA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z9r | OMEGA-3POLYUNSATURATEDFATTY ACID SYNTHASESUBUNIT PFAD (Shewanellaoneidensis) |
PF03060(NMO) | 5 | LEU A 136GLY A 132ALA A 114SER A 115LEU A 118 | None | 1.10A | 5ikqB-4z9rA:undetectable | 5ikqB-4z9rA:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zqb | NADP-DEPENDENTDEHYDROGENASE (Rhodobactersphaeroides) |
PF02826(2-Hacid_dh_C) | 5 | VAL A 176LEU A 198GLY A 149ALA A 150LEU A 154 | None | 0.96A | 5ikqB-4zqbA:undetectable | 5ikqB-4zqbA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a62 | PUTATIVE ALPHA/BETAHYDROLASE FOLDPROTEIN (CandidatusNitrososphaeragargensis) |
PF00561(Abhydrolase_1) | 5 | ARG A 207VAL A 213VAL A 203GLY A 205SER A 209 | None | 0.94A | 5ikqB-5a62A:undetectable | 5ikqB-5a62A:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c5h | 2-SUCCINYLBENZOATE--COA LIGASE (Escherichiacoli) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 6 | ARG A 337LEU A 345TYR A 269VAL A 348GLY A 338LEU A 351 | None | 1.49A | 5ikqB-5c5hA:undetectable | 5ikqB-5c5hA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cbk | SHHTL5 (Strigahermonthica) |
PF12697(Abhydrolase_6) | 5 | LEU A 77VAL A 103GLY A 101ALA A 102SER A 98 | None | 0.99A | 5ikqB-5cbkA:undetectable | 5ikqB-5cbkA:18.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cwv | NUCLEOPORIN NUP192 (Chaetomiumthermophilum) |
PF11894(Nup192) | 5 | VAL A1596LEU A1597LEU A1729GLY A1647ALA A1648 | None | 1.09A | 5ikqB-5cwvA:undetectable | 5ikqB-5cwvA:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e3i | HISTIDINE--TRNALIGASE (Acinetobacterbaumannii) |
PF03129(HGTP_anticodon)PF13393(tRNA-synt_His) | 5 | LEU A 43TYR A 109GLY A 89ALA A 88LEU A 293 | None | 0.84A | 5ikqB-5e3iA:undetectable | 5ikqB-5e3iA:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fii | PHENYLALANINE-4-HYDROXYLASE (Homo sapiens) |
PF01842(ACT) | 5 | VAL A 51LEU A 54GLY A 103ALA A 104LEU A 41 | None | 1.12A | 5ikqB-5fiiA:undetectable | 5ikqB-5fiiA:12.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5grm | STIMULATOR OFINTERFERON GENESPROTEIN (Rattusnorvegicus) |
no annotation | 5 | LEU A 259LEU A 330GLY A 255ALA A 256LEU A 190 | None | 1.08A | 5ikqB-5grmA:undetectable | 5ikqB-5grmA:17.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5id4 | DSBA-LIKE PROTEIN (Proteusmirabilis) |
PF13462(Thioredoxin_4) | 5 | LEU A 177VAL A 125ALA A 121SER A 118LEU A 150 | None | 1.13A | 5ikqB-5id4A:undetectable | 5ikqB-5id4A:17.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ihv | BETA-LACTAMASE (Burkholderiaambifaria) |
PF13354(Beta-lactamase2) | 5 | LEU A 167LEU A 104VAL A 52ALA A 55LEU A 176 | None | 1.12A | 5ikqB-5ihvA:undetectable | 5ikqB-5ihvA:15.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ikr | PROSTAGLANDIN G/HSYNTHASE 2 (Homo sapiens) |
PF00008(EGF)PF03098(An_peroxidase) | 12 | ARG A 120VAL A 349LEU A 352TYR A 355LEU A 384TYR A 385TRP A 387VAL A 523GLY A 526ALA A 527SER A 530LEU A 531 | ID8 A 601 ( 4.4A)ID8 A 601 (-3.9A)ID8 A 601 (-4.1A)ID8 A 601 (-3.8A)ID8 A 601 ( 4.8A)ID8 A 601 ( 3.5A)COH A 602 (-4.5A)ID8 A 601 (-3.6A)ID8 A 601 (-3.5A)ID8 A 601 (-3.5A)ID8 A 601 (-2.7A)ID8 A 601 (-3.5A) | 0.36A | 5ikqB-5ikrA:63.9 | 5ikqB-5ikrA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ipx | ORF49 PROTEIN (Humangammaherpesvirus8) |
PF04793(Herpes_BBRF1) | 6 | ARG A 160LEU A 208VAL A 153GLY A 154ALA A 155LEU A 159 | SO4 A 402 (-4.1A)NoneNoneNoneNoneNone | 1.48A | 5ikqB-5ipxA:undetectable | 5ikqB-5ipxA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jvb | PHOSPHONATE ABCTRANSPORTER,PERIPLASMICPHOSPHONATE-BINDINGPROTEIN (Trichodesmiumerythraeum) |
no annotation | 6 | VAL A 163LEU A 177TYR A 125VAL A 104GLY A 106ALA A 174 | None | 1.30A | 5ikqB-5jvbA:undetectable | 5ikqB-5jvbA:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lc5 | NADH-UBIQUINONEOXIDOREDUCTASE CHAIN4 (Bos taurus) |
PF00361(Proton_antipo_M)PF01059(Oxidored_q5_N) | 5 | LEU M 14VAL M 25ALA M 29SER M 31LEU M 32 | None | 1.07A | 5ikqB-5lc5M:undetectable | 5ikqB-5lc5M:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m32 | PROTEASOME SUBUNITBETA TYPE-2 (Homo sapiens) |
PF00227(Proteasome) | 5 | LEU J 4TYR J 117GLY J 135ALA J 136LEU J 140 | None | 0.96A | 5ikqB-5m32J:undetectable | 5ikqB-5m32J:16.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nug | CYTOPLASMIC DYNEIN 1HEAVY CHAIN 1 (Homo sapiens) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 5 | VAL A4309LEU A4312TRP A4320GLY A4152ALA A4155 | None | 1.03A | 5ikqB-5nugA:undetectable | 5ikqB-5nugA:7.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5od2 | BIFUNCTIONALADP-SPECIFICGLUCOKINASE/PHOSPHOFRUCTOKINASE (Methanocaldococcusjannaschii) |
no annotation | 5 | LEU A 315TYR A 312GLY A 331ALA A 332LEU A 336 | None | 1.13A | 5ikqB-5od2A:undetectable | 5ikqB-5od2A:10.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tp4 | AMIDASE,HYDANTOINASE/CARBAMOYLASE FAMILY (Burkholderiaambifaria) |
PF01546(Peptidase_M20) | 5 | ARG A 93VAL A 97LEU A 101TRP A 49ALA A 20 | EDO A 506 (-3.6A)NoneNoneNoneEDO A 506 ( 4.9A) | 1.12A | 5ikqB-5tp4A:undetectable | 5ikqB-5tp4A:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tul | TETRACYCLINEDESTRUCTASE TET(55) (unculturedbacterium) |
PF01494(FAD_binding_3) | 5 | TYR A 292LEU A 32GLY A 16ALA A 15SER A 13 | NoneNoneNonePO4 A 401 (-3.5A)PO4 A 401 (-3.5A) | 1.02A | 5ikqB-5tulA:undetectable | 5ikqB-5tulA:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uld | TRANSPORTER, NADCFAMILY (Vibrio cholerae) |
PF00939(Na_sulph_symp) | 5 | LEU A 270VAL A 295GLY A 298ALA A 299LEU A 303 | None | 0.96A | 5ikqB-5uldA:undetectable | 5ikqB-5uldA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wp6 | TRANSIENT RECEPTORPOTENTIAL CATIONCHANNEL SUBFAMILY MMEMBER 4 (Homo sapiens) |
no annotation | 5 | LEU A 564LEU A 657GLY A 591ALA A 592LEU A 596 | None | 1.11A | 5ikqB-5wp6A:undetectable | 5ikqB-5wp6A:9.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wqk | SULFURTRANSFERASE (Mus musculus) |
PF00581(Rhodanese) | 5 | LEU A 232VAL A 257GLY A 260ALA A 261SER A 264 | None | 1.10A | 5ikqB-5wqkA:undetectable | 5ikqB-5wqkA:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xhq | APOLIPOPROTEINN-ACYLTRANSFERASE (Escherichiacoli) |
PF00795(CN_hydrolase) | 5 | LEU A 149LEU A 26ALA A 37SER A 40LEU A 41 | None | 1.05A | 5ikqB-5xhqA:1.2 | 5ikqB-5xhqA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z96 | SHORT TRANSIENTRECEPTOR POTENTIALCHANNEL 4 (Mus musculus) |
no annotation | 5 | LEU A 83VAL A 109GLY A 110ALA A 111LEU A 100 | None | 1.12A | 5ikqB-5z96A:undetectable | 5ikqB-5z96A:10.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6aqj | KETOL-ACIDREDUCTOISOMERASE(NADP(+)) (Staphylococcusaureus) |
no annotation | 5 | LEU A 36TYR A 41ALA A 168SER A 166LEU A 165 | None | 1.14A | 5ikqB-6aqjA:undetectable | 5ikqB-6aqjA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bar | ROD SHAPEDETERMINING PROTEINRODA (Thermusthermophilus) |
no annotation | 5 | LEU A 181LEU A 327GLY A 155ALA A 156LEU A 148 | None | 1.10A | 5ikqB-6barA:undetectable | 5ikqB-6barA:11.48 |