SIMILAR PATTERNS OF AMINO ACIDS FOR 5IKQ_A_JMSA602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3b PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermotoga
maritima) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A  95
LEU A 370
VAL A 345
GLY A 343
ALA A 342
 None
 1.04A 5ikqA-1b3bA:
0.0		 5ikqA-1b3bA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvu PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermococcus
litoralis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A  95
LEU A 372
VAL A 347
GLY A 345
ALA A 344
 None
 0.98A 5ikqA-1bvuA:
undetectable		 5ikqA-1bvuA:
20.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		10 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 384
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.46A 5ikqA-1ebvA:
33.9		 5ikqA-1ebvA:
63.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtm GLUTAMATE
DEHYDROGENASE

(Pyrococcus
furiosus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A  95
LEU A 373
VAL A 348
GLY A 346
ALA A 345
 None
 1.03A 5ikqA-1gtmA:
undetectable		 5ikqA-1gtmA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 267
GLY A 189
ALA A 188
SER A 187
LEU A 127
 None
 0.94A 5ikqA-1h4lA:
undetectable		 5ikqA-1h4lA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htt HISTIDYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 LEU A  43
TYR A 107
GLY A  87
ALA A  86
LEU A 291
 None
 0.86A 5ikqA-1httA:
undetectable		 5ikqA-1httA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jgc BACTERIOFERRITIN

(Rhodobacter
capsulatus) 		PF00210
(Ferritin) 		5 VAL A 131
LEU A 134
TYR A  25
GLY A  93
LEU A  98
 None
 1.11A 5ikqA-1jgcA:
undetectable		 5ikqA-1jgcA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF06087
(Tyr-DNA_phospho) 		5 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 1.01A 5ikqA-1jy1A:
0.0		 5ikqA-1jy1A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k72 ENDOGLUCANASE 9G

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		5 LEU A 323
VAL A 261
GLY A 264
ALA A 265
LEU A 269
 None
 1.10A 5ikqA-1k72A:
0.0		 5ikqA-1k72A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1f GLUTAMATE
DEHYDROGENASE 1

(Homo sapiens) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A 121
LEU A 457
VAL A 382
GLY A 380
ALA A 379
 None
 1.07A 5ikqA-1l1fA:
0.0		 5ikqA-1l1fA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mgt PROTEIN
(O6-METHYLGUANINE-DN
A METHYLTRANSFERASE)

(Thermococcus
kodakarensis) 		PF01035
(DNA_binding_1)
PF09153
(DUF1938) 		5 VAL A 138
LEU A  43
VAL A  18
GLY A  26
LEU A  84
 None
 0.99A 5ikqA-1mgtA:
undetectable		 5ikqA-1mgtA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Homo sapiens) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 VAL A  99
LEU A   8
LEU A  68
GLY A 127
LEU A 132
 None
None
XMP  A 901 (-4.1A)
XMP  A 901 (-3.4A)
None
 1.01A 5ikqA-1pl0A:
undetectable		 5ikqA-1pl0A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum) 		PF01593
(Amino_oxidase) 		5 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
 None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
 1.06A 5ikqA-1sezA:
undetectable		 5ikqA-1sezA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2d GLUTAMINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		5 LEU A  51
LEU A  43
GLY A 262
ALA A 261
LEU A  63
 None
 1.07A 5ikqA-1v2dA:
undetectable		 5ikqA-1v2dA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Thermotoga
maritima) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A  74
GLY A   8
ALA A   9
SER A  34
LEU A  55
 None
 0.95A 5ikqA-1vknA:
undetectable		 5ikqA-1vknA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0u INITIATION FACTOR 2B

(Leishmania
major) 		PF01008
(IF-2B) 		5 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.12A 5ikqA-2a0uA:
undetectable		 5ikqA-2a0uA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ark FLAVODOXIN

(Aquifex
aeolicus) 		PF00258
(Flavodoxin_1) 		5 VAL A   6
LEU A  36
GLY A  25
ALA A  26
LEU A 158
 None
 1.03A 5ikqA-2arkA:
undetectable		 5ikqA-2arkA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 223
 None
 1.01A 5ikqA-2elcA:
undetectable		 5ikqA-2elcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 285
 None
 0.94A 5ikqA-2elcA:
undetectable		 5ikqA-2elcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 VAL A 215
TYR A 238
LEU A  74
GLY A 290
ALA A 289
 None
 0.81A 5ikqA-2elcA:
undetectable		 5ikqA-2elcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fiy PROTEIN FDHE HOMOLOG

(Pseudomonas
aeruginosa) 		PF04216
(FdhE) 		5 LEU A 125
LEU A 140
GLY A 157
ALA A 158
LEU A  55
 None
 1.08A 5ikqA-2fiyA:
undetectable		 5ikqA-2fiyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE

(Pseudomonas
aeruginosa) 		PF00682
(HMGL-like) 		5 VAL A 274
LEU A 273
GLY A 236
ALA A 235
SER A 290
 None
 1.06A 5ikqA-2ftpA:
undetectable		 5ikqA-2ftpA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk9 PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE II,
GAMMA

(Homo sapiens) 		PF01504
(PIP5K) 		5 LEU A 126
TYR A 189
GLY A  54
ALA A  56
SER A  58
 None
 1.00A 5ikqA-2gk9A:
undetectable		 5ikqA-2gk9A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hr3 PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF13463
(HTH_27) 		5 LEU A 104
VAL A  39
GLY A  42
ALA A  43
LEU A  47
 None
 0.94A 5ikqA-2hr3A:
undetectable		 5ikqA-2hr3A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 238
TYR A 194
VAL A 227
GLY A 171
ALA A 229
 None
 1.07A 5ikqA-2j6iA:
undetectable		 5ikqA-2j6iA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE

(Ruegeria sp.
TM1040) 		PF07859
(Abhydrolase_3) 		5 TRP A  81
GLY A 138
ALA A 137
SER A 136
LEU A 168
 None
None
None
UNL  A 263 (-3.7A)
None
 1.10A 5ikqA-2pblA:
undetectable		 5ikqA-2pblA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjr PROTEIN (HELICASE
PCRA)

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 VAL A  40
LEU A  41
GLY A 250
ALA A  31
LEU A 282
 None
 1.10A 5ikqA-2pjrA:
undetectable		 5ikqA-2pjrA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r48 PHOSPHOTRANSFERASE
SYSTEM (PTS)
MANNOSE-SPECIFIC
ENZYME IIBCA
COMPONENT

(Bacillus
subtilis) 		PF02302
(PTS_IIB) 		5 VAL A  67
VAL A  82
GLY A  81
ALA A  62
SER A  79
 None
 1.11A 5ikqA-2r48A:
undetectable		 5ikqA-2r48A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uwj TYPE III EXPORT
PROTEIN PSCG

(Pseudomonas
aeruginosa) 		PF09477
(Type_III_YscG) 		5 LEU G  14
LEU G  70
TRP G  73
ALA G  40
LEU G  32
 None
 1.05A 5ikqA-2uwjG:
undetectable		 5ikqA-2uwjG:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy0 ANGIOTENSINOGEN

(Mus musculus) 		PF00079
(Serpin) 		6 VAL C 130
LEU C 128
LEU C 114
VAL C 146
GLY C 143
LEU C  11
 None
None
NA  C1456 ( 4.9A)
None
NA  C1456 (-4.0A)
None
 1.33A 5ikqA-2wy0C:
undetectable		 5ikqA-2wy0C:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xec PUTATIVE MALEATE
ISOMERASE

(Nocardia
farcinica) 		no annotation 5 LEU A 158
VAL A 174
ALA A 178
SER A 180
LEU A 181
 None
 1.01A 5ikqA-2xecA:
undetectable		 5ikqA-2xecA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn8 PUTATIVE CYTOCHROME
P450 125

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 VAL A 313
LEU A 415
VAL A 267
GLY A 269
ALA A 268
 HEM  A1434 ( 4.9A)
None
None
HEM  A1434 (-3.3A)
HEM  A1434 (-3.5A)
 0.99A 5ikqA-2xn8A:
undetectable		 5ikqA-2xn8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ylz PHENYLACETONE
MONOOXYGENASE

(Thermobifida
fusca) 		PF13738
(Pyr_redox_3) 		5 LEU A 146
VAL A  21
GLY A  23
ALA A 149
SER A 150
 None
None
FAD  A 700 (-3.3A)
None
FAD  A 700 (-4.9A)
 1.10A 5ikqA-2ylzA:
undetectable		 5ikqA-2ylzA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE
IRON-SULFUR
ATP-BINDING PROTEIN

(Prochlorococcus
marinus) 		PF00142
(Fer4_NifH) 		5 VAL A 152
LEU A 153
GLY A 159
ALA A 162
LEU A 165
 None
 1.07A 5ikqA-2ynmA:
undetectable		 5ikqA-2ynmA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3at7 ALGINATE-BINDING
FLAGELLIN

(Sphingomonas
sp. A1) 		PF09375
(Peptidase_M75) 		5 LEU A  87
VAL A 158
GLY A 160
ALA A 162
LEU A 165
 None
 1.09A 5ikqA-3at7A:
undetectable		 5ikqA-3at7A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2s PUTATIVE NADH-FLAVIN
REDUCTASE

(Lactobacillus
paracasei) 		PF13460
(NAD_binding_10) 		5 VAL A  27
LEU A  28
VAL A  31
GLY A   7
ALA A   8
 None
None
None
NDP  A 301 (-3.2A)
None
 1.08A 5ikqA-3h2sA:
undetectable		 5ikqA-3h2sA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 VAL A 247
LEU A 117
VAL A 104
GLY A  40
ALA A  39
 None
 1.12A 5ikqA-3hrdA:
undetectable		 5ikqA-3hrdA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 LEU A 313
GLY A 261
ALA A 260
SER A 259
LEU A 199
 None
 1.04A 5ikqA-3igoA:
undetectable		 5ikqA-3igoA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2z BIRA BIFUNCTIONAL
PROTEIN

(Mycobacterium
tuberculosis) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		5 LEU A 208
LEU A 126
GLY A 106
ALA A 105
LEU A 194
 None
 1.08A 5ikqA-3l2zA:
undetectable		 5ikqA-3l2zA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Sulfolobus
solfataricus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 189
LEU A 142
VAL A 162
ALA A 163
LEU A  44
 None
 1.00A 5ikqA-3l7zA:
undetectable		 5ikqA-3l7zA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg5 EPI-ISOZIZAENE
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 5 LEU A  54
VAL A 139
GLY A 141
ALA A 143
SER A 145
 None
 0.91A 5ikqA-3lg5A:
undetectable		 5ikqA-3lg5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg5 EPI-ISOZIZAENE
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 5 LEU A 121
LEU A  54
GLY A 141
ALA A 143
SER A 145
 None
 1.12A 5ikqA-3lg5A:
undetectable		 5ikqA-3lg5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvu TENA FAMILY
TRANSCRIPTIONAL
REGULATOR

(Ruegeria sp.
TM1040) 		PF03070
(TENA_THI-4) 		5 LEU A  62
VAL A 121
GLY A 125
ALA A 124
SER A 127
 None
None
None
EDO  A 235 (-4.3A)
None
 1.02A 5ikqA-3mvuA:
undetectable		 5ikqA-3mvuA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npi TETR FAMILY
REGULATORY PROTEIN

(Corynebacterium
diphtheriae) 		PF00440
(TetR_N) 		5 ARG A  95
VAL A 207
LEU A 211
VAL A  91
GLY A  93
 None
 1.03A 5ikqA-3npiA:
undetectable		 5ikqA-3npiA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major) 		PF00069
(Pkinase) 		5 LEU A 300
GLY A 220
ALA A 219
SER A 218
LEU A 159
 None
 1.04A 5ikqA-3pg1A:
undetectable		 5ikqA-3pg1A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5g CYAB

(Pseudomonas
aeruginosa) 		PF00211
(Guanylate_cyc) 		5 LEU A 228
TYR A 336
GLY A 291
ALA A 292
LEU A 381
 None
 1.10A 5ikqA-3r5gA:
undetectable		 5ikqA-3r5gA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		5 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 0.97A 5ikqA-3tfyA:
undetectable		 5ikqA-3tfyA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
 None
 1.01A 5ikqA-3uw2A:
undetectable		 5ikqA-3uw2A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wp5 CDBFV

(Neocallimastix
patriciarum) 		PF00457
(Glyco_hydro_11) 		5 LEU A  59
GLY A 204
ALA A 203
SER A  95
LEU A 117
 None
 1.00A 5ikqA-3wp5A:
undetectable		 5ikqA-3wp5A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwy D-LACTATE
DEHYDROGENASE

(Fusobacterium
nucleatum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 VAL A 233
LEU A 232
LEU A 197
GLY A 150
LEU A 161
 None
 0.99A 5ikqA-3wwyA:
undetectable		 5ikqA-3wwyA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a56 PULLULANASE
SECRETION PROTEIN
PULS

(Klebsiella
oxytoca) 		PF09691
(T2SS_PulS_OutS) 		5 LEU A  96
VAL A  42
GLY A  45
ALA A  46
LEU A  58
 None
 1.03A 5ikqA-4a56A:
undetectable		 5ikqA-4a56A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9w MONOOXYGENASE

(Stenotrophomonas
maltophilia) 		PF13738
(Pyr_redox_3) 		5 VAL A 336
LEU A  91
TYR A  85
GLY A  19
ALA A  18
 None
 1.10A 5ikqA-4a9wA:
undetectable		 5ikqA-4a9wA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		5 LEU A1737
GLY A1842
ALA A1841
SER A1844
LEU A1868
 None
 1.11A 5ikqA-4asiA:
undetectable		 5ikqA-4asiA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		5 LEU A  15
VAL A 133
GLY A 135
ALA A 137
LEU A 141
 None
 1.11A 5ikqA-4av6A:
undetectable		 5ikqA-4av6A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0e F1 CAPSULE-ANCHORING
PROTEIN

(Yersinia pestis) 		PF13954
(PapC_N) 		5 VAL A  38
LEU A 113
LEU A  83
ALA A 119
LEU A 120
 None
 1.12A 5ikqA-4b0eA:
undetectable		 5ikqA-4b0eA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxi ACCESSORY GENE
REGULATOR PROTEIN C

(Staphylococcus
aureus) 		PF14501
(HATPase_c_5) 		5 VAL A 425
LEU A 296
GLY A 334
SER A 332
LEU A 400
 None
 1.06A 5ikqA-4bxiA:
undetectable		 5ikqA-4bxiA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE

(Gelatoporia
subvermispora) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 VAL A  28
VAL A 112
GLY A 110
ALA A 109
LEU A  90
 None
 1.10A 5ikqA-4czpA:
undetectable		 5ikqA-4czpA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doe 1,4-BETA-GLUCANASE

(Caldicellulosiruptor
bescii) 		PF00759
(Glyco_hydro_9) 		5 LEU A 346
VAL A 284
GLY A 287
ALA A 288
LEU A 292
 None
 1.05A 5ikqA-4doeA:
undetectable		 5ikqA-4doeA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwq TRNA-SPLICING LIGASE
RTCB

(Pyrococcus
horikoshii) 		PF01139
(RtcB) 		5 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.09A 5ikqA-4dwqA:
undetectable		 5ikqA-4dwqA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h40 PUTATIVE CELL
ADHESION PROTEIN

(Bacteroides
fragilis) 		PF15415
(Mfa_like_2) 		5 ARG A  79
LEU A  98
VAL A 115
ALA A 144
SER A 142
 None
 1.07A 5ikqA-4h40A:
undetectable		 5ikqA-4h40A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhr ALPHA-DIOXYGENASE

(Arabidopsis
thaliana) 		PF03098
(An_peroxidase) 		5 VAL A  41
LEU A 560
TYR A 557
VAL A  61
LEU A  50
 None
None
None
BNG  A 714 ( 4.8A)
BNG  A 714 ( 4.9A)
 1.11A 5ikqA-4hhrA:
29.7		 5ikqA-4hhrA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hka TRYPTOPHAN
2,3-DIOXYGENASE

(Drosophila
melanogaster) 		PF03301
(Trp_dioxygenase) 		5 VAL A 189
LEU A 199
GLY A 275
ALA A 276
LEU A 295
 None
 1.00A 5ikqA-4hkaA:
undetectable		 5ikqA-4hkaA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9u TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKH

(Vibrio
parahaemolyticus) 		PF02386
(TrkH) 		5 VAL A  79
GLY A  81
ALA A  83
SER A  85
LEU A  86
 None
 0.82A 5ikqA-4j9uA:
1.6		 5ikqA-4j9uA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgg ESTERASE TESA

(Pseudomonas
aeruginosa) 		PF13472
(Lipase_GDSL_2) 		5 LEU A  86
LEU A 138
VAL A 130
GLY A 128
ALA A 129
 None
 1.04A 5ikqA-4jggA:
undetectable		 5ikqA-4jggA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY

(Thermococcus
kodakarensis) 		PF00375
(SDF) 		5 VAL A 153
LEU A 154
GLY A 309
ALA A 310
LEU A 284
 None
 1.04A 5ikqA-4ky0A:
undetectable		 5ikqA-4ky0A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2g L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
lavendulae) 		PF02668
(TauD) 		5 ARG A 270
VAL A 261
LEU A 243
VAL A 197
ALA A 271
 None
 1.06A 5ikqA-4m2gA:
undetectable		 5ikqA-4m2gA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtk VGRG1

(Pseudomonas
aeruginosa) 		PF05954
(Phage_GPD) 		5 ARG A 293
VAL A 324
LEU A 344
VAL A 291
LEU A  60
 SO4  A 734 (-3.7A)
None
None
None
None
 1.11A 5ikqA-4mtkA:
undetectable		 5ikqA-4mtkA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1m ENOYL-ACYL CARRIER
REDUCTASE

(Toxoplasma
gondii) 		PF13561
(adh_short_C2) 		5 LEU A 286
VAL A 266
GLY A 268
ALA A 270
LEU A 274
 None
 0.87A 5ikqA-4o1mA:
undetectable		 5ikqA-4o1mA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN

(Pyrococcus
horikoshii) 		PF00375
(SDF) 		5 VAL A 151
LEU A 152
GLY A 306
ALA A 307
LEU A 282
 None
 1.03A 5ikqA-4oyeA:
undetectable		 5ikqA-4oyeA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pde PROTEIN FDHD

(Escherichia
coli) 		PF02634
(FdhD-NarQ) 		5 VAL A 214
LEU A 139
GLY A 232
SER A 228
LEU A 199
 None
 1.11A 5ikqA-4pdeA:
undetectable		 5ikqA-4pdeA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1

(Bos taurus) 		PF13516
(LRR_6) 		5 ARG B 269
LEU B 299
LEU B 263
VAL B 265
GLY B 267
 None
 1.04A 5ikqA-4peqB:
undetectable		 5ikqA-4peqB:
21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 ARG A 121
VAL A 350
LEU A 353
TYR A 356
LEU A 385
TYR A 386
TRP A 388
VAL A 524
GLY A 527
ALA A 528
LEU A 532
 BOG  A 604 ( 3.7A)
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.5A)
None
IBP  A 601 (-4.8A)
None
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 4.9A)
 0.36A 5ikqA-4ph9A:
62.7		 5ikqA-4ph9A:
88.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		10 ARG A 121
VAL A 350
LEU A 353
TYR A 356
TYR A 386
TRP A 388
VAL A 524
ALA A 528
SER A 531
LEU A 532
 BOG  A 604 ( 3.7A)
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.5A)
IBP  A 601 (-4.8A)
None
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
IBP  A 601 ( 4.9A)
 0.61A 5ikqA-4ph9A:
62.7		 5ikqA-4ph9A:
88.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 LEU A1871
TYR A1874
VAL A1283
ALA A1301
LEU A1302
 None
 1.08A 5ikqA-4r7yA:
undetectable		 5ikqA-4r7yA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7z CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus) 		PF00493
(MCM) 		5 LEU A 871
TYR A 874
VAL A 283
ALA A 301
LEU A 302
 None
 1.02A 5ikqA-4r7zA:
undetectable		 5ikqA-4r7zA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubt ACETYL-COA
ACETYLTRANSFERASE
FADA5

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 VAL A 234
LEU A 228
GLY A 243
ALA A 242
SER A 245
 None
None
COA  A 401 ( 4.3A)
COA  A 401 (-3.5A)
COA  A 401 ( 4.0A)
 1.05A 5ikqA-4ubtA:
undetectable		 5ikqA-4ubtA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9r OMEGA-3
POLYUNSATURATED
FATTY ACID SYNTHASE
SUBUNIT PFAD

(Shewanella
oneidensis) 		PF03060
(NMO) 		5 LEU A 136
GLY A 132
ALA A 114
SER A 115
LEU A 118
 None
 1.11A 5ikqA-4z9rA:
undetectable		 5ikqA-4z9rA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqb NADP-DEPENDENT
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		PF02826
(2-Hacid_dh_C) 		5 VAL A 176
LEU A 198
GLY A 149
ALA A 150
LEU A 154
 None
 0.99A 5ikqA-4zqbA:
undetectable		 5ikqA-4zqbA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN

(Candidatus
Nitrososphaera
gargensis) 		PF00561
(Abhydrolase_1) 		5 ARG A 207
VAL A 213
VAL A 203
GLY A 205
SER A 209
 None
 0.95A 5ikqA-5a62A:
undetectable		 5ikqA-5a62A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1q U14 PROTEIN

(Human
betaherpesvirus
6B) 		PF04637
(Herpes_pp85) 		5 LEU A 447
VAL A 434
GLY A 437
ALA A 438
SER A 441
 None
 0.93A 5ikqA-5b1qA:
undetectable		 5ikqA-5b1qA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbk SHHTL5

(Striga
hermonthica) 		PF12697
(Abhydrolase_6) 		5 LEU A  77
VAL A 103
GLY A 101
ALA A 102
SER A  98
 None
 1.02A 5ikqA-5cbkA:
undetectable		 5ikqA-5cbkA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwv NUCLEOPORIN NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 VAL A1596
LEU A1597
LEU A1729
GLY A1647
ALA A1648
 None
 1.09A 5ikqA-5cwvA:
undetectable		 5ikqA-5cwvA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3i HISTIDINE--TRNA
LIGASE

(Acinetobacter
baumannii) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 LEU A  43
TYR A 109
GLY A  89
ALA A  88
LEU A 293
 None
 0.87A 5ikqA-5e3iA:
undetectable		 5ikqA-5e3iA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fii PHENYLALANINE-4-HYDR
OXYLASE

(Homo sapiens) 		PF01842
(ACT) 		5 VAL A  51
LEU A  54
GLY A 103
ALA A 104
LEU A  41
 None
 1.12A 5ikqA-5fiiA:
undetectable		 5ikqA-5fiiA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5id4 DSBA-LIKE PROTEIN

(Proteus
mirabilis) 		PF13462
(Thioredoxin_4) 		5 LEU A 177
VAL A 125
ALA A 121
SER A 118
LEU A 150
 None
 1.10A 5ikqA-5id4A:
undetectable		 5ikqA-5id4A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihv BETA-LACTAMASE

(Burkholderia
ambifaria) 		PF13354
(Beta-lactamase2) 		5 LEU A 167
LEU A 104
VAL A  52
ALA A  55
LEU A 176
 None
 1.11A 5ikqA-5ihvA:
undetectable		 5ikqA-5ihvA:
15.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		12 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 384
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 4.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.40A 5ikqA-5ikrA:
63.6		 5ikqA-5ikrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inf CARBOXYL TRANSFERASE

(Streptomyces
ambofaciens) 		PF01039
(Carboxyl_trans) 		5 LEU A 512
VAL A 371
ALA A 336
SER A 334
LEU A 327
 None
 1.08A 5ikqA-5infA:
undetectable		 5ikqA-5infA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN

(Trichodesmium
erythraeum) 		no annotation 6 VAL A 163
LEU A 177
TYR A 125
VAL A 104
GLY A 106
ALA A 174
 None
 1.27A 5ikqA-5jvbA:
undetectable		 5ikqA-5jvbA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF01059
(Oxidored_q5_N) 		5 LEU M  14
VAL M  25
ALA M  29
SER M  31
LEU M  32
 None
 1.04A 5ikqA-5lc5M:
undetectable		 5ikqA-5lc5M:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m32 PROTEASOME SUBUNIT
BETA TYPE-2

(Homo sapiens) 		PF00227
(Proteasome) 		5 LEU J   4
TYR J 117
GLY J 135
ALA J 136
LEU J 140
 None
 0.94A 5ikqA-5m32J:
undetectable		 5ikqA-5m32J:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 1.05A 5ikqA-5nugA:
undetectable		 5ikqA-5nugA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tp4 AMIDASE,
HYDANTOINASE/CARBAMO
YLASE FAMILY

(Burkholderia
ambifaria) 		PF01546
(Peptidase_M20) 		5 ARG A  93
VAL A  97
LEU A 101
TRP A  49
ALA A  20
 EDO  A 506 (-3.6A)
None
None
None
EDO  A 506 ( 4.9A)
 1.09A 5ikqA-5tp4A:
undetectable		 5ikqA-5tp4A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tul TETRACYCLINE
DESTRUCTASE TET(55)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 TYR A 292
LEU A  32
GLY A  16
ALA A  15
SER A  13
 None
None
None
PO4  A 401 (-3.5A)
PO4  A 401 (-3.5A)
 0.98A 5ikqA-5tulA:
undetectable		 5ikqA-5tulA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uld TRANSPORTER, NADC
FAMILY

(Vibrio cholerae) 		PF00939
(Na_sulph_symp) 		5 LEU A 270
VAL A 295
GLY A 298
ALA A 299
LEU A 303
 None
 0.94A 5ikqA-5uldA:
0.0		 5ikqA-5uldA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4

(Homo sapiens) 		no annotation 5 LEU A 564
LEU A 657
GLY A 591
ALA A 592
LEU A 596
 None
 1.09A 5ikqA-5wp6A:
undetectable		 5ikqA-5wp6A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqk SULFURTRANSFERASE

(Mus musculus) 		PF00581
(Rhodanese) 		5 LEU A 232
VAL A 257
GLY A 260
ALA A 261
SER A 264
 None
 1.07A 5ikqA-5wqkA:
undetectable		 5ikqA-5wqkA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli) 		PF00795
(CN_hydrolase) 		5 LEU A 149
LEU A  26
ALA A  37
SER A  40
LEU A  41
 None
 1.05A 5ikqA-5xhqA:
1.5		 5ikqA-5xhqA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4

(Mus musculus) 		no annotation 5 LEU A  83
VAL A 109
GLY A 110
ALA A 111
LEU A 100
 None
 1.11A 5ikqA-5z96A:
1.7		 5ikqA-5z96A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bar ROD SHAPE
DETERMINING PROTEIN
RODA

(Thermus
thermophilus) 		no annotation 5 LEU A 181
LEU A 327
GLY A 155
ALA A 156
LEU A 148
 None
 1.10A 5ikqA-6barA:
0.0		 5ikqA-6barA:
11.48