SIMILAR PATTERNS OF AMINO ACIDS FOR 5IKQ_A_JMSA602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3b PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermotoga
maritima) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A  95
LEU A 370
VAL A 345
GLY A 343
ALA A 342
 None
 1.04A 5ikqA-1b3bA:
0.0		 5ikqA-1b3bA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvu PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermococcus
litoralis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A  95
LEU A 372
VAL A 347
GLY A 345
ALA A 344
 None
 0.98A 5ikqA-1bvuA:
undetectable		 5ikqA-1bvuA:
20.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		10 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 384
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.46A 5ikqA-1ebvA:
33.9		 5ikqA-1ebvA:
63.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtm GLUTAMATE
DEHYDROGENASE

(Pyrococcus
furiosus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A  95
LEU A 373
VAL A 348
GLY A 346
ALA A 345
 None
 1.03A 5ikqA-1gtmA:
undetectable		 5ikqA-1gtmA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 267
GLY A 189
ALA A 188
SER A 187
LEU A 127
 None
 0.94A 5ikqA-1h4lA:
undetectable		 5ikqA-1h4lA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htt HISTIDYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 LEU A  43
TYR A 107
GLY A  87
ALA A  86
LEU A 291
 None
 0.86A 5ikqA-1httA:
undetectable		 5ikqA-1httA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jgc BACTERIOFERRITIN

(Rhodobacter
capsulatus) 		PF00210
(Ferritin) 		5 VAL A 131
LEU A 134
TYR A  25
GLY A  93
LEU A  98
 None
 1.11A 5ikqA-1jgcA:
undetectable		 5ikqA-1jgcA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF06087
(Tyr-DNA_phospho) 		5 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 1.01A 5ikqA-1jy1A:
0.0		 5ikqA-1jy1A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k72 ENDOGLUCANASE 9G

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		5 LEU A 323
VAL A 261
GLY A 264
ALA A 265
LEU A 269
 None
 1.10A 5ikqA-1k72A:
0.0		 5ikqA-1k72A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1f GLUTAMATE
DEHYDROGENASE 1

(Homo sapiens) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A 121
LEU A 457
VAL A 382
GLY A 380
ALA A 379
 None
 1.07A 5ikqA-1l1fA:
0.0		 5ikqA-1l1fA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mgt PROTEIN
(O6-METHYLGUANINE-DN
A METHYLTRANSFERASE)

(Thermococcus
kodakarensis) 		PF01035
(DNA_binding_1)
PF09153
(DUF1938) 		5 VAL A 138
LEU A  43
VAL A  18
GLY A  26
LEU A  84
 None
 0.99A 5ikqA-1mgtA:
undetectable		 5ikqA-1mgtA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Homo sapiens) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 VAL A  99
LEU A   8
LEU A  68
GLY A 127
LEU A 132
 None
None
XMP  A 901 (-4.1A)
XMP  A 901 (-3.4A)
None
 1.01A 5ikqA-1pl0A:
undetectable		 5ikqA-1pl0A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum) 		PF01593
(Amino_oxidase) 		5 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
 None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
 1.06A 5ikqA-1sezA:
undetectable		 5ikqA-1sezA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2d GLUTAMINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		5 LEU A  51
LEU A  43
GLY A 262
ALA A 261
LEU A  63
 None
 1.07A 5ikqA-1v2dA:
undetectable		 5ikqA-1v2dA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Thermotoga
maritima) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A  74
GLY A   8
ALA A   9
SER A  34
LEU A  55
 None
 0.95A 5ikqA-1vknA:
undetectable		 5ikqA-1vknA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0u INITIATION FACTOR 2B

(Leishmania
major) 		PF01008
(IF-2B) 		5 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.12A 5ikqA-2a0uA:
undetectable		 5ikqA-2a0uA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ark FLAVODOXIN

(Aquifex
aeolicus) 		PF00258
(Flavodoxin_1) 		5 VAL A   6
LEU A  36
GLY A  25
ALA A  26
LEU A 158
 None
 1.03A 5ikqA-2arkA:
undetectable		 5ikqA-2arkA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 223
 None
 1.01A 5ikqA-2elcA:
undetectable		 5ikqA-2elcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 285
 None
 0.94A 5ikqA-2elcA:
undetectable		 5ikqA-2elcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 VAL A 215
TYR A 238
LEU A  74
GLY A 290
ALA A 289
 None
 0.81A 5ikqA-2elcA:
undetectable		 5ikqA-2elcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fiy PROTEIN FDHE HOMOLOG

(Pseudomonas
aeruginosa) 		PF04216
(FdhE) 		5 LEU A 125
LEU A 140
GLY A 157
ALA A 158
LEU A  55
 None
 1.08A 5ikqA-2fiyA:
undetectable		 5ikqA-2fiyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE

(Pseudomonas
aeruginosa) 		PF00682
(HMGL-like) 		5 VAL A 274
LEU A 273
GLY A 236
ALA A 235
SER A 290
 None
 1.06A 5ikqA-2ftpA:
undetectable		 5ikqA-2ftpA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk9 PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE II,
GAMMA

(Homo sapiens) 		PF01504
(PIP5K) 		5 LEU A 126
TYR A 189
GLY A  54
ALA A  56
SER A  58
 None
 1.00A 5ikqA-2gk9A:
undetectable		 5ikqA-2gk9A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hr3 PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF13463
(HTH_27) 		5 LEU A 104
VAL A  39
GLY A  42
ALA A  43
LEU A  47
 None
 0.94A 5ikqA-2hr3A:
undetectable		 5ikqA-2hr3A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 238
TYR A 194
VAL A 227
GLY A 171
ALA A 229
 None
 1.07A 5ikqA-2j6iA:
undetectable		 5ikqA-2j6iA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE

(Ruegeria sp.
TM1040) 		PF07859
(Abhydrolase_3) 		5 TRP A  81
GLY A 138
ALA A 137
SER A 136
LEU A 168
 None
None
None
UNL  A 263 (-3.7A)
None
 1.10A 5ikqA-2pblA:
undetectable		 5ikqA-2pblA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjr PROTEIN (HELICASE
PCRA)

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 VAL A  40
LEU A  41
GLY A 250
ALA A  31
LEU A 282
 None
 1.10A 5ikqA-2pjrA:
undetectable		 5ikqA-2pjrA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r48 PHOSPHOTRANSFERASE
SYSTEM (PTS)
MANNOSE-SPECIFIC
ENZYME IIBCA
COMPONENT

(Bacillus
subtilis) 		PF02302
(PTS_IIB) 		5 VAL A  67
VAL A  82
GLY A  81
ALA A  62
SER A  79
 None
 1.11A 5ikqA-2r48A:
undetectable		 5ikqA-2r48A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uwj TYPE III EXPORT
PROTEIN PSCG

(Pseudomonas
aeruginosa) 		PF09477
(Type_III_YscG) 		5 LEU G  14
LEU G  70
TRP G  73
ALA G  40
LEU G  32
 None
 1.05A 5ikqA-2uwjG:
undetectable		 5ikqA-2uwjG:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy0 ANGIOTENSINOGEN

(Mus musculus) 		PF00079
(Serpin) 		6 VAL C 130
LEU C 128
LEU C 114
VAL C 146
GLY C 143
LEU C  11
 None
None
NA  C1456 ( 4.9A)
None
NA  C1456 (-4.0A)
None
 1.33A 5ikqA-2wy0C:
undetectable		 5ikqA-2wy0C:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xec PUTATIVE MALEATE
ISOMERASE

(Nocardia
farcinica) 		no annotation 5 LEU A 158
VAL A 174
ALA A 178
SER A 180
LEU A 181
 None
 1.01A 5ikqA-2xecA:
undetectable		 5ikqA-2xecA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn8 PUTATIVE CYTOCHROME
P450 125

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 VAL A 313
LEU A 415
VAL A 267
GLY A 269
ALA A 268
 HEM  A1434 ( 4.9A)
None
None
HEM  A1434 (-3.3A)
HEM  A1434 (-3.5A)
 0.99A 5ikqA-2xn8A:
undetectable		 5ikqA-2xn8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ylz PHENYLACETONE
MONOOXYGENASE

(Thermobifida
fusca) 		PF13738
(Pyr_redox_3) 		5 LEU A 146
VAL A  21
GLY A  23
ALA A 149
SER A 150
 None
None
FAD  A 700 (-3.3A)
None
FAD  A 700 (-4.9A)
 1.10A 5ikqA-2ylzA:
undetectable		 5ikqA-2ylzA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE
IRON-SULFUR
ATP-BINDING PROTEIN

(Prochlorococcus
marinus) 		PF00142
(Fer4_NifH) 		5 VAL A 152
LEU A 153
GLY A 159
ALA A 162
LEU A 165
 None
 1.07A 5ikqA-2ynmA:
undetectable		 5ikqA-2ynmA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3at7 ALGINATE-BINDING
FLAGELLIN

(Sphingomonas
sp. A1) 		PF09375
(Peptidase_M75) 		5 LEU A  87
VAL A 158
GLY A 160
ALA A 162
LEU A 165
 None
 1.09A 5ikqA-3at7A:
undetectable		 5ikqA-3at7A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2s PUTATIVE NADH-FLAVIN
REDUCTASE

(Lactobacillus
paracasei) 		PF13460
(NAD_binding_10) 		5 VAL A  27
LEU A  28
VAL A  31
GLY A   7
ALA A   8
 None
None
None
NDP  A 301 (-3.2A)
None
 1.08A 5ikqA-3h2sA:
undetectable		 5ikqA-3h2sA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 VAL A 247
LEU A 117
VAL A 104
GLY A  40
ALA A  39
 None
 1.12A 5ikqA-3hrdA:
undetectable		 5ikqA-3hrdA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 LEU A 313
GLY A 261
ALA A 260
SER A 259
LEU A 199
 None
 1.04A 5ikqA-3igoA:
undetectable		 5ikqA-3igoA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2z BIRA BIFUNCTIONAL
PROTEIN

(Mycobacterium
tuberculosis) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		5 LEU A 208
LEU A 126
GLY A 106
ALA A 105
LEU A 194
 None
 1.08A 5ikqA-3l2zA:
undetectable		 5ikqA-3l2zA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Sulfolobus
solfataricus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 189
LEU A 142
VAL A 162
ALA A 163
LEU A  44
 None
 1.00A 5ikqA-3l7zA:
undetectable		 5ikqA-3l7zA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg5 EPI-ISOZIZAENE
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 5 LEU A  54
VAL A 139
GLY A 141
ALA A 143
SER A 145
 None
 0.91A 5ikqA-3lg5A:
undetectable		 5ikqA-3lg5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg5 EPI-ISOZIZAENE
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 5 LEU A 121
LEU A  54
GLY A 141
ALA A 143
SER A 145
 None
 1.12A 5ikqA-3lg5A:
undetectable		 5ikqA-3lg5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvu TENA FAMILY
TRANSCRIPTIONAL
REGULATOR

(Ruegeria sp.
TM1040) 		PF03070
(TENA_THI-4) 		5 LEU A  62
VAL A 121
GLY A 125
ALA A 124
SER A 127
 None
None
None
EDO  A 235 (-4.3A)
None
 1.02A 5ikqA-3mvuA:
undetectable		 5ikqA-3mvuA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npi TETR FAMILY
REGULATORY PROTEIN

(Corynebacterium
diphtheriae) 		PF00440
(TetR_N) 		5 ARG A  95
VAL A 207
LEU A 211
VAL A  91
GLY A  93
 None
 1.03A 5ikqA-3npiA:
undetectable		 5ikqA-3npiA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major) 		PF00069
(Pkinase) 		5 LEU A 300
GLY A 220
ALA A 219
SER A 218
LEU A 159
 None
 1.04A 5ikqA-3pg1A:
undetectable		 5ikqA-3pg1A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5g CYAB

(Pseudomonas
aeruginosa) 		PF00211
(Guanylate_cyc) 		5 LEU A 228
TYR A 336
GLY A 291
ALA A 292
LEU A 381
 None
 1.10A 5ikqA-3r5gA:
undetectable		 5ikqA-3r5gA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		5 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 0.97A 5ikqA-3tfyA:
undetectable		 5ikqA-3tfyA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
 None
 1.01A 5ikqA-3uw2A:
undetectable		 5ikqA-3uw2A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wp5 CDBFV

(Neocallimastix
patriciarum) 		PF00457
(Glyco_hydro_11) 		5 LEU A  59
GLY A 204
ALA A 203
SER A  95
LEU A 117
 None
 1.00A 5ikqA-3wp5A:
undetectable		 5ikqA-3wp5A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwy D-LACTATE
DEHYDROGENASE

(Fusobacterium
nucleatum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 VAL A 233
LEU A 232
LEU A 197
GLY A 150
LEU A 161
 None
 0.99A 5ikqA-3wwyA:
undetectable		 5ikqA-3wwyA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a56 PULLULANASE
SECRETION PROTEIN
PULS

(Klebsiella
oxytoca) 		PF09691
(T2SS_PulS_OutS) 		5 LEU A  96
VAL A  42
GLY A  45
ALA A  46
LEU A  58
 None
 1.03A 5ikqA-4a56A:
undetectable		 5ikqA-4a56A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9w MONOOXYGENASE

(Stenotrophomonas
maltophilia) 		PF13738
(Pyr_redox_3) 		5 VAL A 336
LEU A  91
TYR A  85
GLY A  19
ALA A  18
 None
 1.10A 5ikqA-4a9wA:
undetectable		 5ikqA-4a9wA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		5 LEU A1737
GLY A1842
ALA A1841
SER A1844
LEU A1868
 None
 1.11A 5ikqA-4asiA:
undetectable		 5ikqA-4asiA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		5 LEU A  15
VAL A 133
GLY A 135
ALA A 137
LEU A 141
 None
 1.11A 5ikqA-4av6A:
undetectable		 5ikqA-4av6A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0e F1 CAPSULE-ANCHORING
PROTEIN

(Yersinia pestis) 		PF13954
(PapC_N) 		5 VAL A  38
LEU A 113
LEU A  83
ALA A 119
LEU A 120
 None
 1.12A 5ikqA-4b0eA:
undetectable		 5ikqA-4b0eA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxi ACCESSORY GENE
REGULATOR PROTEIN C

(Staphylococcus
aureus) 		PF14501
(HATPase_c_5) 		5 VAL A 425
LEU A 296
GLY A 334
SER A 332
LEU A 400
 None
 1.06A 5ikqA-4bxiA:
undetectable		 5ikqA-4bxiA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE

(Gelatoporia
subvermispora) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 VAL A  28
VAL A 112
GLY A 110
ALA A 109
LEU A  90
 None
 1.10A 5ikqA-4czpA:
undetectable		 5ikqA-4czpA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doe 1,4-BETA-GLUCANASE

(Caldicellulosiruptor
bescii) 		PF00759
(Glyco_hydro_9) 		5 LEU A 346
VAL A 284
GLY A 287
ALA A 288
LEU A 292
 None
 1.05A 5ikqA-4doeA:
undetectable		 5ikqA-4doeA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwq TRNA-SPLICING LIGASE
RTCB

(Pyrococcus
horikoshii) 		PF01139
(RtcB) 		5 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.09A 5ikqA-4dwqA:
undetectable		 5ikqA-4dwqA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h40 PUTATIVE CELL
ADHESION PROTEIN

(Bacteroides
fragilis) 		PF15415
(Mfa_like_2) 		5 ARG A  79
LEU A  98
VAL A 115
ALA A 144
SER A 142
 None
 1.07A 5ikqA-4h40A:
undetectable		 5ikqA-4h40A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhr ALPHA-DIOXYGENASE

(Arabidopsis
thaliana) 		PF03098
(An_peroxidase) 		5 VAL A  41
LEU A 560
TYR A 557
VAL A  61
LEU A  50
 None
None
None
BNG  A 714 ( 4.8A)
BNG  A 714 ( 4.9A)
 1.11A 5ikqA-4hhrA:
29.7		 5ikqA-4hhrA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hka TRYPTOPHAN
2,3-DIOXYGENASE

(Drosophila
melanogaster) 		PF03301
(Trp_dioxygenase) 		5 VAL A 189
LEU A 199
GLY A 275
ALA A 276
LEU A 295
 None
 1.00A 5ikqA-4hkaA:
undetectable		 5ikqA-4hkaA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9u TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKH

(Vibrio
parahaemolyticus) 		PF02386
(TrkH) 		5 VAL A  79
GLY A  81
ALA A  83
SER A  85
LEU A  86
 None
 0.82A 5ikqA-4j9uA:
1.6		 5ikqA-4j9uA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgg ESTERASE TESA

(Pseudomonas
aeruginosa) 		PF13472
(Lipase_GDSL_2) 		5 LEU A  86
LEU A 138
VAL A 130
GLY A 128
ALA A 129
 None
 1.04A 5ikqA-4jggA:
undetectable		 5ikqA-4jggA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY

(Thermococcus
kodakarensis) 		PF00375
(SDF) 		5 VAL A 153
LEU A 154
GLY A 309
ALA A 310
LEU A 284
 None
 1.04A 5ikqA-4ky0A:
undetectable		 5ikqA-4ky0A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2g L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
lavendulae) 		PF02668
(TauD) 		5 ARG A 270
VAL A 261
LEU A 243
VAL A 197
ALA A 271
 None
 1.06A 5ikqA-4m2gA:
undetectable		 5ikqA-4m2gA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtk VGRG1

(Pseudomonas
aeruginosa) 		PF05954
(Phage_GPD) 		5 ARG A 293
VAL A 324
LEU A 344
VAL A 291
LEU A  60
 SO4  A 734 (-3.7A)
None
None
None
None
 1.11A 5ikqA-4mtkA:
undetectable		 5ikqA-4mtkA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1m ENOYL-ACYL CARRIER
REDUCTASE

(Toxoplasma
gondii) 		PF13561
(adh_short_C2) 		5 LEU A 286
VAL A 266
GLY A 268
ALA A 270
LEU A 274
 None
 0.87A 5ikqA-4o1mA:
undetectable		 5ikqA-4o1mA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN

(Pyrococcus
horikoshii) 		PF00375
(SDF) 		5 VAL A 151
LEU A 152
GLY A 306
ALA A 307
LEU A 282
 None
 1.03A 5ikqA-4oyeA:
undetectable		 5ikqA-4oyeA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pde PROTEIN FDHD

(Escherichia
coli) 		PF02634
(FdhD-NarQ) 		5 VAL A 214
LEU A 139
GLY A 232
SER A 228
LEU A 199
 None
 1.11A 5ikqA-4pdeA:
undetectable		 5ikqA-4pdeA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1

(Bos taurus) 		PF13516
(LRR_6) 		5 ARG B 269
LEU B 299
LEU B 263
VAL B 265
GLY B 267
 None
 1.04A 5ikqA-4peqB:
undetectable		 5ikqA-4peqB:
21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 ARG A 121
VAL A 350
LEU A 353
TYR A 356
LEU A 385
TYR A 386
TRP A 388
VAL A 524
GLY A 527
ALA A 528
LEU A 532
 BOG  A 604 ( 3.7A)
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.5A)
None
IBP  A 601 (-4.8A)
None
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 4.9A)
 0.36A 5ikqA-4ph9A:
62.7		 5ikqA-4ph9A:
88.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		10 ARG A 121
VAL A 350
LEU A 353
TYR A 356
TYR A 386
TRP A 388
VAL A 524
ALA A 528
SER A 531
LEU A 532
 BOG  A 604 ( 3.7A)
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.5A)
IBP  A 601 (-4.8A)
None
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
IBP  A 601 ( 4.9A)
 0.61A 5ikqA-4ph9A:
62.7		 5ikqA-4ph9A:
88.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 LEU A1871
TYR A1874
VAL A1283
ALA A1301
LEU A1302
 None
 1.08A 5ikqA-4r7yA:
undetectable		 5ikqA-4r7yA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7z CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus) 		PF00493
(MCM) 		5 LEU A 871
TYR A 874
VAL A 283
ALA A 301
LEU A 302
 None
 1.02A 5ikqA-4r7zA:
undetectable		 5ikqA-4r7zA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubt ACETYL-COA
ACETYLTRANSFERASE
FADA5

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 VAL A 234
LEU A 228
GLY A 243
ALA A 242
SER A 245
 None
None
COA  A 401 ( 4.3A)
COA  A 401 (-3.5A)
COA  A 401 ( 4.0A)
 1.05A 5ikqA-4ubtA:
undetectable		 5ikqA-4ubtA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9r OMEGA-3
POLYUNSATURATED
FATTY ACID SYNTHASE
SUBUNIT PFAD

(Shewanella
oneidensis) 		PF03060
(NMO) 		5 LEU A 136
GLY A 132
ALA A 114
SER A 115
LEU A 118
 None
 1.11A 5ikqA-4z9rA:
undetectable		 5ikqA-4z9rA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqb NADP-DEPENDENT
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		PF02826
(2-Hacid_dh_C) 		5 VAL A 176
LEU A 198
GLY A 149
ALA A 150
LEU A 154
 None
 0.99A 5ikqA-4zqbA:
undetectable		 5ikqA-4zqbA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN

(Candidatus
Nitrososphaera
gargensis) 		PF00561
(Abhydrolase_1) 		5 ARG A 207
VAL A 213
VAL A 203
GLY A 205
SER A 209
 None
 0.95A 5ikqA-5a62A:
undetectable		 5ikqA-5a62A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1q U14 PROTEIN

(Human
betaherpesvirus
6B) 		PF04637
(Herpes_pp85) 		5 LEU A 447
VAL A 434
GLY A 437
ALA A 438
SER A 441
 None
 0.93A 5ikqA-5b1qA:
undetectable		 5ikqA-5b1qA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbk SHHTL5

(Striga
hermonthica) 		PF12697
(Abhydrolase_6) 		5 LEU A  77
VAL A 103
GLY A 101
ALA A 102
SER A  98
 None
 1.02A 5ikqA-5cbkA:
undetectable		 5ikqA-5cbkA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwv NUCLEOPORIN NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 VAL A1596
LEU A1597
LEU A1729
GLY A1647
ALA A1648
 None
 1.09A 5ikqA-5cwvA:
undetectable		 5ikqA-5cwvA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3i HISTIDINE--TRNA
LIGASE

(Acinetobacter
baumannii) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 LEU A  43
TYR A 109
GLY A  89
ALA A  88
LEU A 293
 None
 0.87A 5ikqA-5e3iA:
undetectable		 5ikqA-5e3iA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fii PHENYLALANINE-4-HYDR
OXYLASE

(Homo sapiens) 		PF01842
(ACT) 		5 VAL A  51
LEU A  54
GLY A 103
ALA A 104
LEU A  41
 None
 1.12A 5ikqA-5fiiA:
undetectable		 5ikqA-5fiiA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5id4 DSBA-LIKE PROTEIN

(Proteus
mirabilis) 		PF13462
(Thioredoxin_4) 		5 LEU A 177
VAL A 125
ALA A 121
SER A 118
LEU A 150
 None
 1.10A 5ikqA-5id4A:
undetectable		 5ikqA-5id4A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihv BETA-LACTAMASE

(Burkholderia
ambifaria) 		PF13354
(Beta-lactamase2) 		5 LEU A 167
LEU A 104
VAL A  52
ALA A  55
LEU A 176
 None
 1.11A 5ikqA-5ihvA:
undetectable		 5ikqA-5ihvA:
15.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		12 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 384
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 4.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.40A 5ikqA-5ikrA:
63.6		 5ikqA-5ikrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inf CARBOXYL TRANSFERASE

(Streptomyces
ambofaciens) 		PF01039
(Carboxyl_trans) 		5 LEU A 512
VAL A 371
ALA A 336
SER A 334
LEU A 327
 None
 1.08A 5ikqA-5infA:
undetectable		 5ikqA-5infA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN

(Trichodesmium
erythraeum) 		no annotation 6 VAL A 163
LEU A 177
TYR A 125
VAL A 104
GLY A 106
ALA A 174
 None
 1.27A 5ikqA-5jvbA:
undetectable		 5ikqA-5jvbA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF01059
(Oxidored_q5_N) 		5 LEU M  14
VAL M  25
ALA M  29
SER M  31
LEU M  32
 None
 1.04A 5ikqA-5lc5M:
undetectable		 5ikqA-5lc5M:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m32 PROTEASOME SUBUNIT
BETA TYPE-2

(Homo sapiens) 		PF00227
(Proteasome) 		5 LEU J   4
TYR J 117
GLY J 135
ALA J 136
LEU J 140
 None
 0.94A 5ikqA-5m32J:
undetectable		 5ikqA-5m32J:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 1.05A 5ikqA-5nugA:
undetectable		 5ikqA-5nugA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tp4 AMIDASE,
HYDANTOINASE/CARBAMO
YLASE FAMILY

(Burkholderia
ambifaria) 		PF01546
(Peptidase_M20) 		5 ARG A  93
VAL A  97
LEU A 101
TRP A  49
ALA A  20
 EDO  A 506 (-3.6A)
None
None
None
EDO  A 506 ( 4.9A)
 1.09A 5ikqA-5tp4A:
undetectable		 5ikqA-5tp4A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tul TETRACYCLINE
DESTRUCTASE TET(55)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 TYR A 292
LEU A  32
GLY A  16
ALA A  15
SER A  13
 None
None
None
PO4  A 401 (-3.5A)
PO4  A 401 (-3.5A)
 0.98A 5ikqA-5tulA:
undetectable		 5ikqA-5tulA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uld TRANSPORTER, NADC
FAMILY

(Vibrio cholerae) 		PF00939
(Na_sulph_symp) 		5 LEU A 270
VAL A 295
GLY A 298
ALA A 299
LEU A 303
 None
 0.94A 5ikqA-5uldA:
0.0		 5ikqA-5uldA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4

(Homo sapiens) 		no annotation 5 LEU A 564
LEU A 657
GLY A 591
ALA A 592
LEU A 596
 None
 1.09A 5ikqA-5wp6A:
undetectable		 5ikqA-5wp6A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqk SULFURTRANSFERASE

(Mus musculus) 		PF00581
(Rhodanese) 		5 LEU A 232
VAL A 257
GLY A 260
ALA A 261
SER A 264
 None
 1.07A 5ikqA-5wqkA:
undetectable		 5ikqA-5wqkA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli) 		PF00795
(CN_hydrolase) 		5 LEU A 149
LEU A  26
ALA A  37
SER A  40
LEU A  41
 None
 1.05A 5ikqA-5xhqA:
1.5		 5ikqA-5xhqA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4

(Mus musculus) 		no annotation 5 LEU A  83
VAL A 109
GLY A 110
ALA A 111
LEU A 100
 None
 1.11A 5ikqA-5z96A:
1.7		 5ikqA-5z96A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bar ROD SHAPE
DETERMINING PROTEIN
RODA

(Thermus
thermophilus) 		no annotation 5 LEU A 181
LEU A 327
GLY A 155
ALA A 156
LEU A 148
 None
 1.10A 5ikqA-6barA:
0.0		 5ikqA-6barA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)

(Klebsiella
aerogenes) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		3 VAL C 377
SER C 297
MET C 364
 None
 0.91A 5ikqA-1a5lC:
0.0		 5ikqA-1a5lC:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajz DIHYDROPTEROATE
SYNTHASE

(Escherichia
coli) 		PF00809
(Pterin_bind) 		3 VAL A 230
SER A 237
MET A 218
 None
 0.94A 5ikqA-1ajzA:
0.0		 5ikqA-1ajzA:
19.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		3 VAL A 116
SER A 353
MET A 522
 None
 0.38A 5ikqA-1ebvA:
33.9		 5ikqA-1ebvA:
63.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f45 INTERLEUKIN-12 ALPHA
CHAIN

(Homo sapiens) 		PF03039
(IL12) 		3 VAL B 190
SER B 104
MET B 145
 None
 0.91A 5ikqA-1f45B:
undetectable		 5ikqA-1f45B:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		3 VAL A 249
SER A 213
MET A 265
 None
PPE  A 413 (-2.8A)
None
 0.77A 5ikqA-1geyA:
0.0		 5ikqA-1geyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE

(Oryza sativa) 		PF00834
(Ribul_P_3_epim) 		3 VAL A 146
SER A 201
MET A  12
 None
SO4  A1224 (-3.1A)
None
 0.94A 5ikqA-1h1yA:
0.0		 5ikqA-1h1yA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7y METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2)
PF02965
(Met_synt_B12) 		3 VAL A 769
SER A 955
MET A1087
 None
B12  A1248 ( 4.5A)
None
 0.93A 5ikqA-1k7yA:
0.0		 5ikqA-1k7yA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1paq TRANSLATION
INITIATION FACTOR
EIF-2B EPSILON
SUBUNIT

(Saccharomyces
cerevisiae) 		PF02020
(W2) 		3 VAL A 596
SER A 657
MET A 636
 None
 0.94A 5ikqA-1paqA:
undetectable		 5ikqA-1paqA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		3 VAL A 167
SER A 159
MET A 366
 None
 0.94A 5ikqA-1pw4A:
undetectable		 5ikqA-1pw4A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qst TGCN5 HISTONE ACETYL
TRANSFERASE

(Tetrahymena
thermophila) 		PF00583
(Acetyltransf_1) 		3 VAL A 106
SER A  96
MET A 142
 None
 0.80A 5ikqA-1qstA:
0.0		 5ikqA-1qstA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqh CARBOXYLESTERASE
PRECURSOR

(Geobacillus
stearothermophilus) 		PF12146
(Hydrolase_4) 		3 VAL A 188
SER A 221
MET A 195
 None
 0.86A 5ikqA-1tqhA:
0.0		 5ikqA-1tqhA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzy 33 KDA CHAPERONIN

(Bacillus
subtilis) 		PF01430
(HSP33) 		3 VAL A 218
SER A 156
MET A 180
 None
 0.89A 5ikqA-1vzyA:
0.0		 5ikqA-1vzyA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w52 PANCREATIC LIPASE
RELATED PROTEIN 2

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 VAL X  75
SER X 273
MET X 309
 None
 0.90A 5ikqA-1w52X:
undetectable		 5ikqA-1w52X:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkt FATTY ACID SYNTHASE

(Homo sapiens) 		PF00975
(Thioesterase) 		3 VAL A2472
SER A2340
MET A2317
 None
 0.93A 5ikqA-1xktA:
undetectable		 5ikqA-1xktA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygh PROTEIN
(TRANSCRIPTIONAL
ACTIVATOR GCN5)

(Saccharomyces
cerevisiae) 		PF00583
(Acetyltransf_1) 		3 VAL A 157
SER A 147
MET A 193
 None
 0.77A 5ikqA-1yghA:
undetectable		 5ikqA-1yghA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA

(Escherichia
coli) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		3 VAL A1354
SER A1126
MET A1133
 None
 0.74A 5ikqA-2bruA:
undetectable		 5ikqA-2bruA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1q LUCIFERIN
4-MONOOXYGENASE

(Luciola
cruciata) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 VAL A 368
SER A 349
MET A 400
 None
 0.86A 5ikqA-2d1qA:
undetectable		 5ikqA-2d1qA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg9 ADP-RIBOSYL CYCLASE
1

(Mus musculus) 		PF02267
(Rib_hydrolayse) 		3 VAL A 246
SER A 259
MET A 268
 None
 0.87A 5ikqA-2eg9A:
undetectable		 5ikqA-2eg9A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHO

(Pseudomonas
stutzeri) 		PF04663
(Phenol_monoox) 		3 VAL E 106
SER E  68
MET E 114
 None
 0.94A 5ikqA-2inpE:
undetectable		 5ikqA-2inpE:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 VAL A  52
SER A 117
MET A 187
 None
 0.91A 5ikqA-2iwzA:
undetectable		 5ikqA-2iwzA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7n RNA-DEPENDENT RNA
POLYMERASE

(Neurospora
crassa) 		PF05183
(RdRP) 		3 VAL A 977
SER A 992
MET A 922
 None
 0.87A 5ikqA-2j7nA:
undetectable		 5ikqA-2j7nA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ls8 C-TYPE LECTIN DOMAIN
FAMILY 4 MEMBER D

(Homo sapiens) 		PF00059
(Lectin_C) 		3 VAL A 116
SER A  59
MET A  39
 None
 0.86A 5ikqA-2ls8A:
undetectable		 5ikqA-2ls8A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5i SALMONELLA
TYPHIMURIUM DB7155
BACTERIOPHAGE DET7
TAILSPIKE

(unidentified
phage) 		PF09251
(PhageP22-tail) 		3 VAL A 379
SER A 429
MET A 479
 None
 0.88A 5ikqA-2v5iA:
undetectable		 5ikqA-2v5iA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		3 VAL A1636
SER A1647
MET A1601
 None
 0.93A 5ikqA-2vz9A:
undetectable		 5ikqA-2vz9A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 VAL A 528
SER A 410
MET A 385
 None
 0.87A 5ikqA-2x58A:
undetectable		 5ikqA-2x58A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4o PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		3 VAL A 342
SER A 412
MET A 371
 None
 0.82A 5ikqA-2y4oA:
undetectable		 5ikqA-2y4oA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN

(Thermotoga
maritima) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		3 VAL A 190
SER A 162
MET A 172
 None
 0.91A 5ikqA-2yyzA:
undetectable		 5ikqA-2yyzA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a74 LYSYL-TRNA
SYNTHETASE

(Geobacillus
stearothermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 VAL A  90
SER A 106
MET A  66
 None
 0.87A 5ikqA-3a74A:
undetectable		 5ikqA-3a74A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE

(Mesorhizobium
japonicum) 		PF08241
(Methyltransf_11) 		3 VAL A 129
SER A 112
MET A  37
 None
 0.90A 5ikqA-3bkwA:
undetectable		 5ikqA-3bkwA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blz NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION

(Shewanella
baltica) 		PF12893
(Lumazine_bd_2) 		3 VAL A 110
SER A  38
MET A  32
 None
 0.69A 5ikqA-3blzA:
undetectable		 5ikqA-3blzA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8v PUTATIVE
ACETYLTRANSFERASE

(Desulfovibrio
alaskensis) 		no annotation 3 VAL A 181
SER A 157
MET A 144
 None
 0.86A 5ikqA-3c8vA:
undetectable		 5ikqA-3c8vA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dd6 RIBONUCLEASE PH

(Bacillus
anthracis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		3 VAL A  32
SER A 163
MET A 192
 None
 0.94A 5ikqA-3dd6A:
undetectable		 5ikqA-3dd6A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh4 SODIUM/GLUCOSE
COTRANSPORTER

(Vibrio
parahaemolyticus) 		PF00474
(SSF) 		3 VAL A 297
SER A  91
MET A 532
 None
GAL  A 701 (-2.5A)
None
 0.77A 5ikqA-3dh4A:
0.0		 5ikqA-3dh4A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmy PROTEIN FDRA

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		3 VAL A 511
SER A 178
MET A 191
 None
 0.86A 5ikqA-3dmyA:
undetectable		 5ikqA-3dmyA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g01 GRANZYME C

(Mus musculus) 		PF00089
(Trypsin) 		3 VAL A 230
SER A 107
MET A 111
 None
 0.94A 5ikqA-3g01A:
undetectable		 5ikqA-3g01A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		3 VAL A 393
SER A 151
MET A 224
 None
 0.82A 5ikqA-3hpaA:
undetectable		 5ikqA-3hpaA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i44 ALDEHYDE
DEHYDROGENASE

(Bartonella
henselae) 		PF00171
(Aldedh) 		3 VAL A 325
SER A 176
MET A 154
 None
 0.85A 5ikqA-3i44A:
undetectable		 5ikqA-3i44A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Desulfovibrio
vulgaris) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 VAL A 175
SER A 347
MET A 206
 None
 0.93A 5ikqA-3iwaA:
undetectable		 5ikqA-3iwaA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jqy POLYSIALIC ACID
O-ACETYLTRANSFERASE

(Escherichia
coli) 		no annotation 3 VAL B 196
SER B 188
MET B 134
 None
 0.87A 5ikqA-3jqyB:
undetectable		 5ikqA-3jqyB:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqa ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		3 VAL G 250
SER G 483
MET G  99
 None
 0.90A 5ikqA-3lqaG:
undetectable		 5ikqA-3lqaG:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m49 TRANSKETOLASE

(Bacillus
anthracis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 VAL A 214
SER A 202
MET A 161
 None
 0.68A 5ikqA-3m49A:
undetectable		 5ikqA-3m49A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7n PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1

(Archaeoglobus
fulgidus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		3 VAL D 104
SER D 161
MET D 158
 None
 0.91A 5ikqA-3m7nD:
0.4		 5ikqA-3m7nD:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obe SUGAR PHOSPHATE
ISOMERASE/EPIMERASE

(Parabacteroides
distasonis) 		PF01261
(AP_endonuc_2) 		3 VAL A 153
SER A 103
MET A 109
 None
 0.83A 5ikqA-3obeA:
undetectable		 5ikqA-3obeA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouo NUCLEOPROTEIN

(Rift Valley
fever
phlebovirus) 		PF05733
(Tenui_N) 		3 VAL A 204
SER A 170
MET A 145
 None
 0.89A 5ikqA-3ouoA:
undetectable		 5ikqA-3ouoA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf7 BENZOYL-COA
OXYGENASE COMPONENT
B

(Azoarcus
evansii) 		no annotation 3 VAL A 158
SER A  30
MET A  38
 None
 0.92A 5ikqA-3pf7A:
undetectable		 5ikqA-3pf7A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pty ARABINOSYLTRANSFERAS
E C

(Mycobacterium
tuberculosis) 		PF14896
(Arabino_trans_C) 		3 VAL A 885
SER A 866
MET A 863
 None
 0.85A 5ikqA-3ptyA:
undetectable		 5ikqA-3ptyA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbd 3-DEHYDROQUINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01761
(DHQ_synthase) 		3 VAL A 274
SER A 299
MET A 184
 None
 0.93A 5ikqA-3qbdA:
undetectable		 5ikqA-3qbdA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc2 GLYCOSYL HYDROLASE

(Bacteroides
ovatus) 		PF04041
(Glyco_hydro_130) 		3 VAL A  88
SER A 175
MET A 159
 None
 0.79A 5ikqA-3qc2A:
undetectable		 5ikqA-3qc2A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 VAL C 789
SER C 805
MET C 826
 None
 0.88A 5ikqA-3sr6C:
undetectable		 5ikqA-3sr6C:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sze SERINE PROTEASE ESPP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		3 VAL A 898
SER A 877
MET A 815
 None
 0.90A 5ikqA-3szeA:
undetectable		 5ikqA-3szeA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		no annotation 3 VAL A 587
SER A 467
MET A 563
 None
 0.90A 5ikqA-3vu0A:
undetectable		 5ikqA-3vu0A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Thermus
thermophilus) 		PF00551
(Formyl_trans_N)
PF01842
(ACT) 		3 VAL A 261
SER A 195
MET A 250
 None
 0.82A 5ikqA-3w7bA:
undetectable		 5ikqA-3w7bA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waj TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Archaeoglobus
fulgidus) 		PF02516
(STT3) 		3 VAL A 771
SER A 549
MET A 678
 None
 0.83A 5ikqA-3wajA:
0.1		 5ikqA-3wajA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgc L-ALLO-THREONINE
ALDOLASE

(Aeromonas
jandaei) 		PF01212
(Beta_elim_lyase) 		3 VAL A  11
SER A 307
MET A 299
 None
 0.90A 5ikqA-3wgcA:
undetectable		 5ikqA-3wgcA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0y DSZC

(Rhodococcus
erythropolis) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		3 VAL A 326
SER A 248
MET A 103
 None
 0.88A 5ikqA-3x0yA:
undetectable		 5ikqA-3x0yA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius) 		PF03512
(Glyco_hydro_52) 		3 VAL A  37
SER A 314
MET A 331
 None
 0.93A 5ikqA-4c1oA:
undetectable		 5ikqA-4c1oA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8o ANKYRIN-2

(Homo sapiens) 		PF00531
(Death)
PF00791
(ZU5) 		3 VAL A1321
SER A1028
MET A1294
 None
 0.86A 5ikqA-4d8oA:
undetectable		 5ikqA-4d8oA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3l BMAL1B
CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF14598
(PAS_11) 		3 VAL B 162
SER B 284
MET A 114
 None
 0.88A 5ikqA-4f3lB:
undetectable		 5ikqA-4f3lB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		3 VAL A 434
SER A 440
MET A 416
 None
 0.94A 5ikqA-4fnqA:
undetectable		 5ikqA-4fnqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbs PUTATIVE HYDROLASE

(Bacteroides
ovatus) 		PF16396
(DUF5005) 		3 VAL A 266
SER A 343
MET A 340
 None
 0.92A 5ikqA-4hbsA:
undetectable		 5ikqA-4hbsA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE

(Trypanosoma
brucei) 		PF01156
(IU_nuc_hydro) 		3 VAL A 238
SER A  24
MET A  54
 None
 0.83A 5ikqA-4i70A:
undetectable		 5ikqA-4i70A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4s NUCLEOCAPSID PROTEIN

(SFTS
phlebovirus) 		PF05733
(Tenui_N) 		3 VAL A 205
SER A 171
MET A 145
 None
 0.78A 5ikqA-4j4sA:
undetectable		 5ikqA-4j4sA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8b COATOMER ALPHA
SUBUNIT

(Schizosaccharomyces
pombe) 		PF00400
(WD40) 		3 VAL A 207
SER A 137
MET A 141
 None
 0.87A 5ikqA-4j8bA:
undetectable		 5ikqA-4j8bA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxb GLUTAMYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 VAL A 448
SER A 420
MET A 436
 None
 0.86A 5ikqA-4kxbA:
undetectable		 5ikqA-4kxbA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 VAL A 141
SER A 214
MET A 263
 None
 0.68A 5ikqA-4l52A:
undetectable		 5ikqA-4l52A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN

(Rattus
norvegicus) 		no annotation 3 VAL A 166
SER A 105
MET A 117
 None
 0.77A 5ikqA-4lc9A:
0.0		 5ikqA-4lc9A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m46 LUCIFERASE

(Lampyris
turkestanicus) 		PF00501
(AMP-binding) 		3 VAL A 366
SER A 347
MET A 398
 None
 0.78A 5ikqA-4m46A:
undetectable		 5ikqA-4m46A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m62 T117

(synthetic
construct) 		PF00359
(PTS_EIIA_2) 		3 VAL S  45
SER S  87
MET S   9
 None
 0.93A 5ikqA-4m62S:
undetectable		 5ikqA-4m62S:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		3 VAL A 521
SER A 514
MET A 257
 None
 0.78A 5ikqA-4mk0A:
undetectable		 5ikqA-4mk0A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		3 VAL B 355
SER B 377
MET B 384
 None
 0.57A 5ikqA-4nfuB:
undetectable		 5ikqA-4nfuB:
20.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		3 VAL A 117
SER A 354
MET A 523
 BOG  A 604 (-3.9A)
None
None
 0.26A 5ikqA-4ph9A:
62.7		 5ikqA-4ph9A:
88.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi4 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C) 		3 VAL A 643
SER A 695
MET A 309
 None
None
FAD  A 901 ( 4.9A)
 0.93A 5ikqA-4qi4A:
undetectable		 5ikqA-4qi4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		3 VAL A 789
SER A 805
MET A 826
 None
 0.91A 5ikqA-4yswA:
undetectable		 5ikqA-4yswA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomyces
pombe) 		PF00483
(NTP_transferase) 		3 VAL E 402
SER E 394
MET E 361
 None
 0.55A 5ikqA-5b04E:
undetectable		 5ikqA-5b04E:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bo6 SIA-ALPHA-2,3-GAL-BE
TA-1,4-GLCNAC-R:ALPH
A
2,8-SIALYLTRANSFERAS
E

(Homo sapiens) 		PF00777
(Glyco_transf_29) 		3 VAL A 121
SER A 115
MET A 282
 None
 0.92A 5ikqA-5bo6A:
undetectable		 5ikqA-5bo6A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elx ATP-DEPENDENT RNA
HELICASE DBP5

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 VAL A 278
SER A 271
MET A 134
 None
 0.80A 5ikqA-5elxA:
undetectable		 5ikqA-5elxA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fuu HIV-1 ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		3 VAL A 254
SER A 481
MET A 100
 None
 0.67A 5ikqA-5fuuA:
undetectable		 5ikqA-5fuuA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyz LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding) 		3 VAL A 366
SER A 347
MET A 398
 None
7BV  A 500 (-2.3A)
None
 0.84A 5ikqA-5gyzA:
undetectable		 5ikqA-5gyzA:
23.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		3 VAL A 116
SER A 353
MET A 522
 None
ID8  A 601 ( 4.7A)
ID8  A 601 (-4.2A)
 0.27A 5ikqA-5ikrA:
63.6		 5ikqA-5ikrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyv LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 VAL A 366
SER A 347
MET A 398
 None
SLU  A 601 (-3.5A)
None
 0.84A 5ikqA-5kyvA:
undetectable		 5ikqA-5kyvA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldw NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
8, MITOCHONDRIAL

(Bos taurus) 		PF01058
(Oxidored_q6)
PF12838
(Fer4_7) 		3 VAL B 114
SER I 140
MET I 113
 None
 0.90A 5ikqA-5ldwB:
undetectable		 5ikqA-5ldwB:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtv EH DOMAIN-CONTAINING
PROTEIN 4

(Mus musculus) 		PF00350
(Dynamin_N)
PF16880
(EHD_N) 		3 VAL A 185
SER A 157
MET A 140
 None
 0.80A 5ikqA-5mtvA:
undetectable		 5ikqA-5mtvA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz8 ALDEHYDE
DEHYDROGENASE 21

(Physcomitrella
patens) 		PF00171
(Aldedh) 		3 VAL A 181
SER A 168
MET A 266
 None
 0.75A 5ikqA-5mz8A:
undetectable		 5ikqA-5mz8A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n81 TYROCIDINE SYNTHASE
1

(Brevibacillus
parabrevis) 		no annotation 3 VAL A 378
SER A 210
MET A 241
 None
 0.90A 5ikqA-5n81A:
undetectable		 5ikqA-5n81A:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7e COLH PROTEIN

(Hathewaya
histolytica) 		no annotation 3 VAL A 604
SER A 510
MET A 592
 None
 0.82A 5ikqA-5o7eA:
undetectable		 5ikqA-5o7eA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oe7 UBIQUITIN
THIOESTERASE OTULIN

(Homo sapiens) 		PF16218
(Peptidase_C101) 		3 VAL A 304
SER A 308
MET A 108
 None
 0.86A 5ikqA-5oe7A:
undetectable		 5ikqA-5oe7A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2

(Homo sapiens) 		PF04056
(Ssl1) 		3 VAL E  92
SER E 121
MET E  58
 None
 0.82A 5ikqA-5of4E:
undetectable		 5ikqA-5of4E:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj3 -

(-) 		no annotation 3 VAL A 357
SER A 389
MET A 386
 None
 0.72A 5ikqA-5oj3A:
undetectable		 5ikqA-5oj3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt 40S RIBOSOMAL
PROTEIN S33,
PUTATIVE
40S RIBOSOMAL
PROTEIN S5, PUTATIVE

(Trypanosoma
cruzi) 		no annotation 3 VAL U  49
SER O  25
MET O 130
 None
None
A  E2148 ( 4.7A)
 0.86A 5ikqA-5optU:
undetectable		 5ikqA-5optU:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um8 GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		3 VAL G 254
SER G 481
MET G 100
 None
 0.92A 5ikqA-5um8G:
undetectable		 5ikqA-5um8G:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usw DIHYDROPTEROATE
SYNTHASE

(Aliivibrio
fischeri) 		PF00809
(Pterin_bind) 		3 VAL A 230
SER A 237
MET A 218
 None
 0.82A 5ikqA-5uswA:
undetectable		 5ikqA-5uswA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		3 VAL A 521
SER A 514
MET A 257
 None
 0.81A 5ikqA-5uuuA:
undetectable		 5ikqA-5uuuA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y8p PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		no annotation 3 VAL A 102
SER A  92
MET A 133
 None
 0.49A 5ikqA-5y8pA:
undetectable		 5ikqA-5y8pA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yx3 CHALCONE-FLAVONONE
ISOMERASE FAMILY
PROTEIN

(Deschampsia
antarctica) 		no annotation 3 VAL A   7
SER A 196
MET A  35
 None
 0.74A 5ikqA-5yx3A:
undetectable		 5ikqA-5yx3A:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 3 VAL 2 374
SER 2 289
MET 2 794
 None
 0.87A 5ikqA-5zvs2:
undetectable		 5ikqA-5zvs2:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT C

(Flavobacterium
johnsoniae) 		no annotation 3 VAL C 311
SER C 270
MET C 300
 None
 0.82A 5ikqA-6btmC:
undetectable		 5ikqA-6btmC:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE

(Mycobacterium
tuberculosis) 		no annotation 3 VAL C  49
SER C 133
MET C 130
 None
 0.84A 5ikqA-6eicC:
undetectable		 5ikqA-6eicC:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epi ZETA_1 TOXIN

(Neisseria
gonorrhoeae) 		no annotation 3 VAL B 161
SER B 117
MET B 123
 None
 0.83A 5ikqA-6epiB:
undetectable		 5ikqA-6epiB:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k POLYSULPHIDE
REDUCTASE NRFD

(Rhodothermus
marinus) 		no annotation 3 VAL C 319
SER C 278
MET C 308
 None
 0.86A 5ikqA-6f0kC:
0.0		 5ikqA-6f0kC:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Cyanidioschyzon
merolae) 		no annotation 3 VAL B 588
SER B 344
MET B 350
 None
CLA  B1222 (-3.3A)
None
 0.80A 5ikqA-6fosB:
0.0		 5ikqA-6fosB:
9.86