SIMILAR PATTERNS OF AMINO ACIDS FOR 5IK1_A_CAMA503

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)

(Klebsiella
aerogenes) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 GLY C  56
VAL C  69
ASP C  85
ILE C 110
 None
 0.78A 5ik1A-1a5lC:
0.0		 5ik1A-1a5lC:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6t IGG1 FAB1-IA FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY B  82
VAL B  12
ASP B  10
VAL B 111
 None
 0.82A 5ik1A-1a6tB:
undetectable		 5ik1A-1a6tB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ab6 CHEMOTAXIS PROTEIN
CHEY

(Escherichia
coli) 		PF00072
(Response_reg) 		4 GLY A  39
VAL A  83
ILE A  55
VAL A  54
 None
 0.79A 5ik1A-1ab6A:
undetectable		 5ik1A-1ab6A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b2w PROTEIN (ANTIBODY
(HEAVY CHAIN))

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 PHE H 126
GLY H 122
THR H 209
VAL H 202
VAL H 211
 None
 1.36A 5ik1A-1b2wH:
0.0		 5ik1A-1b2wH:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2y PROTEIN (LUMAZINE
SYNTHASE)

(Spinacia
oleracea) 		PF00885
(DMRL_synthase) 		4 GLY A  67
VAL A  51
ILE A  18
VAL A  19
 None
 0.72A 5ik1A-1c2yA:
undetectable		 5ik1A-1c2yA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cns CHITINASE

(Hordeum vulgare) 		PF00182
(Glyco_hydro_19) 		5 GLY A  43
THR A  47
VAL A  52
ILE A 172
VAL A 173
 None
 1.48A 5ik1A-1cnsA:
1.8		 5ik1A-1cnsA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.) 		PF00067
(p450) 		4 GLY A 268
THR A 271
VAL A 314
VAL A 415
 HEM  A 430 (-3.4A)
HEM  A 430 (-3.7A)
HEM  A 430 (-4.3A)
None
 0.73A 5ik1A-1cptA:
42.3		 5ik1A-1cptA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cw0 PROTEIN (DNA
MISMATCH
ENDONUCLEASE)

(Escherichia
coli) 		PF03852
(Vsr) 		4 GLY A  48
VAL A 111
ILE A  61
VAL A  60
 None
 0.77A 5ik1A-1cw0A:
undetectable		 5ik1A-1cw0A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dub 2-ENOYL-COA
HYDRATASE

(Rattus
norvegicus) 		PF00378
(ECH_1) 		4 GLY A 172
THR A 176
ILE A 165
VAL A 192
 CAA  A 300 (-3.2A)
None
None
None
 0.82A 5ik1A-1dubA:
0.0		 5ik1A-1dubA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4y ADENYLATE KINASE

(Escherichia
coli) 		PF00406
(ADK)
PF05191
(ADK_lid) 		5 GLY A  85
THR A  31
ASP A  61
ILE A  65
VAL A  64
 AP5  A 215 (-4.4A)
AP5  A 215 (-3.4A)
None
None
AP5  A 215 (-4.5A)
 1.37A 5ik1A-1e4yA:
0.0		 5ik1A-1e4yA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4y ADENYLATE KINASE

(Escherichia
coli) 		PF00406
(ADK)
PF05191
(ADK_lid) 		5 GLY A  85
THR A  31
VAL A  64
ASP A  61
ILE A  65
 AP5  A 215 (-4.4A)
AP5  A 215 (-3.4A)
AP5  A 215 (-4.5A)
None
None
 1.09A 5ik1A-1e4yA:
0.0		 5ik1A-1e4yA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4y ADENYLATE KINASE

(Escherichia
coli) 		PF00406
(ADK)
PF05191
(ADK_lid) 		5 GLY A  85
THR A  31
VAL A  64
ILE A  65
VAL A  68
 AP5  A 215 (-4.4A)
AP5  A 215 (-3.4A)
AP5  A 215 (-4.5A)
None
None
 1.36A 5ik1A-1e4yA:
0.0		 5ik1A-1e4yA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyy ALDEHYDE
DEHYDROGENASE

(Vibrio harveyi) 		PF00171
(Aldedh) 		4 GLY A 156
THR A 159
VAL A 171
VAL A 142
 None
 0.80A 5ik1A-1eyyA:
undetectable		 5ik1A-1eyyA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0i INOSITOL
MONOPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF00459
(Inositol_P) 		5 PHE A  98
GLY A 111
VAL A  78
ILE A  80
VAL A  79
 None
 1.32A 5ik1A-1g0iA:
undetectable		 5ik1A-1g0iA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpm GMP SYNTHETASE

(Escherichia
coli) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 GLY A  88
VAL A 100
ASP A 145
VAL A 147
 None
 0.80A 5ik1A-1gpmA:
undetectable		 5ik1A-1gpmA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9r IMMUNOGLOBULIN H

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 PHE H 127
GLY H 123
THR H 210
VAL H 203
VAL H 212
 None
 1.34A 5ik1A-1i9rH:
undetectable		 5ik1A-1i9rH:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itu RENAL DIPEPTIDASE

(Homo sapiens) 		PF01244
(Peptidase_M19) 		4 GLY A 287
VAL A  60
ILE A  17
VAL A  16
 None
 0.77A 5ik1A-1ituA:
undetectable		 5ik1A-1ituA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jjo NEUROSERPIN

(Mus musculus) 		PF00079
(Serpin) 		4 PHE C 178
VAL C 333
ASP C 177
ILE C 354
 None
 0.76A 5ik1A-1jjoC:
undetectable		 5ik1A-1jjoC:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxk ALPHA-AMYLASE,
SALIVARY

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 PHE A 330
GLY A  36
VAL A 333
ILE A  13
VAL A  14
 None
 1.26A 5ik1A-1jxkA:
undetectable		 5ik1A-1jxkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzt HYPOTHETICAL 27.5
KDA PROTEIN IN
SPX19-GCR2
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF03853
(YjeF_N) 		4 GLY A  72
VAL A  90
ILE A  64
VAL A  63
 None
 0.77A 5ik1A-1jztA:
undetectable		 5ik1A-1jztA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kz1 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Schizosaccharomyces
pombe) 		PF00885
(DMRL_synthase) 		4 GLY A  68
VAL A 117
ILE A  82
VAL A  81
 None
 0.79A 5ik1A-1kz1A:
undetectable		 5ik1A-1kz1A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odg DNA MISMATCH
ENDONUCLEASE

(Escherichia
coli) 		PF03852
(Vsr) 		4 GLY A  48
VAL A 111
ILE A  61
VAL A  60
 None
 0.78A 5ik1A-1odgA:
undetectable		 5ik1A-1odgA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ose PORCINE
ALPHA-AMYLASE

(Sus scrofa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 PHE A 335
GLY A  36
VAL A 338
ILE A  13
VAL A  14
 None
 1.25A 5ik1A-1oseA:
undetectable		 5ik1A-1oseA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyp RIBONUCLEASE PH

(Bacillus
subtilis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 GLY A 123
THR A 125
VAL A 118
ILE A 119
VAL A  37
 SO4  A 301 ( 4.0A)
SO4  A 301 (-3.1A)
None
None
None
 1.48A 5ik1A-1oypA:
undetectable		 5ik1A-1oypA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvg DNA TOPOISOMERASE II

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 PHE A 377
GLY A 313
THR A 310
ILE A 357
VAL A 305
 None
 1.25A 5ik1A-1pvgA:
undetectable		 5ik1A-1pvgA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2e EXOCELLOBIOHYDROLASE
I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		4 GLY A 164
ASP A  35
ILE A  34
VAL A  33
 None
 0.82A 5ik1A-1q2eA:
undetectable		 5ik1A-1q2eA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ri3 MRNA CAPPING ENZYME

(Encephalitozoon
cuniculi) 		PF03291
(Pox_MCEL) 		4 THR A  62
VAL A  68
ASP A  70
VAL A 136
 None
None
SAH  A 299 ( 4.9A)
None
 0.76A 5ik1A-1ri3A:
undetectable		 5ik1A-1ri3A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s78 PERTUZUMAB FAB HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 PHE D 122
GLY D 118
THR D 205
VAL D 198
VAL D 207
 None
 1.24A 5ik1A-1s78D:
undetectable		 5ik1A-1s78D:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sbz PROBABLE AROMATIC
ACID DECARBOXYLASE

(Escherichia
coli) 		PF02441
(Flavoprotein) 		4 GLY A  12
VAL A 165
ILE A 161
VAL A 162
 None
 0.68A 5ik1A-1sbzA:
undetectable		 5ik1A-1sbzA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5b ACYL CARRIER PROTEIN
PHOSPHODIESTERASE

(Salmonella
enterica) 		PF02525
(Flavodoxin_2) 		5 GLY A  19
THR A  22
VAL A   6
ILE A  92
VAL A  91
 None
 1.39A 5ik1A-1t5bA:
undetectable		 5ik1A-1t5bA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ued P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		4 GLY A 246
THR A 249
VAL A 292
VAL A 396
 HEM  A1430 (-3.3A)
HEM  A1430 (-3.5A)
HEM  A1430 (-4.4A)
None
 0.77A 5ik1A-1uedA:
38.9		 5ik1A-1uedA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urd MALTOSE-BINDING
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF01547
(SBP_bac_1) 		4 PHE A 343
THR A 123
ILE A 325
VAL A 140
 None
 0.81A 5ik1A-1urdA:
undetectable		 5ik1A-1urdA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve5 THREONINE DEAMINASE

(Thermus
thermophilus) 		PF00291
(PALP) 		4 GLY A  74
VAL A 114
ASP A 116
VAL A  93
 None
 0.81A 5ik1A-1ve5A:
undetectable		 5ik1A-1ve5A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w61 B-CELL MITOGEN

(Trypanosoma
cruzi) 		PF05544
(Pro_racemase) 		4 GLY A 244
VAL A 211
ILE A 222
VAL A 223
 None
 0.75A 5ik1A-1w61A:
undetectable		 5ik1A-1w61A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00291
(PALP) 		5 GLY B 111
THR B 114
VAL B 125
ASP B 126
ILE B 102
 None
 1.49A 5ik1A-1wdwB:
undetectable		 5ik1A-1wdwB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfj CONSERVED
HYPOTHETICAL PROTEIN

(Caulobacter
vibrioides) 		PF02578
(Cu-oxidase_4) 		5 GLY A  19
VAL A 120
ASP A 121
ILE A 126
VAL A 127
 None
 1.09A 5ik1A-1xfjA:
undetectable		 5ik1A-1xfjA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 GLY B 196
VAL B 169
ILE B 173
VAL B 172
 None
 0.72A 5ik1A-1xv9B:
undetectable		 5ik1A-1xv9B:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 SARCOSINE OXIDASE

(Pyrococcus
horikoshii) 		PF01266
(DAO) 		4 GLY B 345
VAL B 198
ILE B   8
VAL B  10
 None
 0.78A 5ik1A-1y56B:
undetectable		 5ik1A-1y56B:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5v TUBULIN GAMMA-1
CHAIN

(Homo sapiens) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 GLY A  18
VAL A  73
ASP A  68
ILE A  74
 None
None
MG  A 475 ( 4.0A)
None
 0.72A 5ik1A-1z5vA:
undetectable		 5ik1A-1z5vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z66 MAJOR ENVELOPE
PROTEIN E

(Langat virus) 		PF02832
(Flavi_glycop_C) 		4 GLY A 369
VAL A 342
ILE A 383
VAL A 385
 None
 0.66A 5ik1A-1z66A:
undetectable		 5ik1A-1z66A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zhv HYPOTHETICAL PROTEIN
ATU0741

(Agrobacterium
fabrum) 		PF13840
(ACT_7) 		4 PHE A  72
VAL A  83
ILE A  79
VAL A  80
 None
 0.75A 5ik1A-1zhvA:
undetectable		 5ik1A-1zhvA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zub REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 1

(Rattus
norvegicus) 		PF00595
(PDZ) 		4 GLY A 662
VAL A 670
ILE A 702
VAL A 703
 None
 0.57A 5ik1A-1zubA:
undetectable		 5ik1A-1zubA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zuw GLUTAMATE RACEMASE 1

(Bacillus
subtilis) 		PF01177
(Asp_Glu_race) 		4 GLY A 209
VAL A   8
ILE A  72
VAL A  71
 None
 0.78A 5ik1A-1zuwA:
undetectable		 5ik1A-1zuwA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2agm POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4

(Azotobacter
vinelandii) 		PF00353
(HemolysinCabind)
PF08548
(Peptidase_M10_C) 		4 GLY A  88
VAL A 143
ASP A  83
VAL A 142
 None
 0.82A 5ik1A-2agmA:
undetectable		 5ik1A-2agmA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmj CENTAURIN GAMMA 1

(Homo sapiens) 		PF00071
(Ras) 		5 PHE A 223
THR A 179
VAL A 177
ILE A 140
VAL A 142
 None
 1.49A 5ik1A-2bmjA:
undetectable		 5ik1A-2bmjA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exr CYTOKININ
DEHYDROGENASE 7

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		4 GLY A  70
VAL A 203
ASP A 195
VAL A 197
 None
 0.78A 5ik1A-2exrA:
undetectable		 5ik1A-2exrA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8t ARGONAUTE PROTEIN

(Aquifex
aeolicus) 		PF02171
(Piwi) 		5 PHE A 560
GLY A 526
VAL A 495
ASP A 496
ILE A 566
 None
 1.29A 5ik1A-2f8tA:
undetectable		 5ik1A-2f8tA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 PHE A 956
GLY A 865
VAL A 962
ILE A 960
VAL A 963
 None
 1.05A 5ik1A-2fgeA:
undetectable		 5ik1A-2fgeA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC

(Treponema
pallidum) 		PF02608
(Bmp) 		4 GLY A 215
VAL A 254
ILE A 235
VAL A 234
 None
 0.76A 5ik1A-2fqxA:
undetectable		 5ik1A-2fqxA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE

(Dictyostelium
discoideum) 		PF01979
(Amidohydro_1) 		4 PHE A 427
GLY A 323
ILE A 357
VAL A 358
 None
 0.76A 5ik1A-2ftwA:
undetectable		 5ik1A-2ftwA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuv PHOSPHOGLUCOMUTASE

(Salmonella
enterica) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 GLY A 494
VAL A 542
ILE A 538
VAL A 539
 None
 0.79A 5ik1A-2fuvA:
undetectable		 5ik1A-2fuvA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv8 RHO-RELATED
GTP-BINDING PROTEIN
RHOB

(Homo sapiens) 		PF00071
(Ras) 		4 GLY A 166
ASP A 155
ILE A 113
VAL A 115
 None
 0.69A 5ik1A-2fv8A:
undetectable		 5ik1A-2fv8A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		4 GLY A 180
VAL A  70
ILE A  40
VAL A  41
 None
None
None
FAD  A 611 (-4.9A)
 0.65A 5ik1A-2gmhA:
undetectable		 5ik1A-2gmhA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqf HYPOTHETICAL PROTEIN
HI0933

(Haemophilus
influenzae) 		PF03486
(HI0933_like) 		4 PHE A 368
GLY A 186
ILE A 353
VAL A 352
 None
 0.82A 5ik1A-2gqfA:
undetectable		 5ik1A-2gqfA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hb6 LEUCINE
AMINOPEPTIDASE 1

(Caenorhabditis
elegans) 		PF00883
(Peptidase_M17) 		4 GLY A 227
VAL A 254
ASP A 257
VAL A 255
 None
None
NA  A3002 ( 3.1A)
None
 0.81A 5ik1A-2hb6A:
undetectable		 5ik1A-2hb6A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho9 CHEMOTAXIS PROTEIN
CHEW

(Escherichia
coli) 		PF01584
(CheW) 		4 GLY A  57
VAL A  88
ILE A 100
VAL A 101
 None
 0.68A 5ik1A-2ho9A:
undetectable		 5ik1A-2ho9A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hvq HYPOTHETICAL 37.6
KDA PROTEIN IN
GP24-HOC INTERGENIC
REGION

(Escherichia
virus T4) 		PF09414
(RNA_ligase) 		5 GLY A 287
THR A 289
VAL A 267
ILE A 271
VAL A 270
 None
 1.26A 5ik1A-2hvqA:
undetectable		 5ik1A-2hvqA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfq GLUTAMATE RACEMASE

(Staphylococcus
aureus) 		PF01177
(Asp_Glu_race) 		4 GLY A 208
VAL A   7
ILE A  70
VAL A  69
 None
 0.79A 5ik1A-2jfqA:
undetectable		 5ik1A-2jfqA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji9 OXALYL-COA
DECARBOXYLASE

(Oxalobacter
formigenes) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLY A 431
VAL A 472
ILE A 447
VAL A 446
 None
 0.79A 5ik1A-2ji9A:
undetectable		 5ik1A-2ji9A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jza NITRITE REDUCTASE
[NAD(P)H] SMALL
SUBUNIT

(Pectobacterium
atrosepticum) 		PF13806
(Rieske_2) 		4 GLY A  18
VAL A  68
ILE A  58
VAL A  59
 None
 0.79A 5ik1A-2jzaA:
undetectable		 5ik1A-2jzaA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k2q SURFACTIN SYNTHETASE
THIOESTERASE SUBUNIT

(Bacillus
subtilis) 		PF00975
(Thioesterase) 		4 PHE B  83
THR B 208
VAL B 109
ILE B 111
 None
 0.71A 5ik1A-2k2qB:
undetectable		 5ik1A-2k2qB:
20.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		7 PHE A  87
GLY A 248
THR A 252
VAL A 295
ASP A 297
ILE A 395
VAL A 396
 CAM  A 502 (-4.6A)
HEM  A 501 (-3.9A)
HEM  A 501 (-3.4A)
HEM  A 501 (-4.6A)
HEM  A 501 (-2.8A)
None
None
 0.76A 5ik1A-2m56A:
58.0		 5ik1A-2m56A:
99.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m6k FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		4 GLY A  68
THR A  54
ILE A  65
VAL A  64
 None
 0.74A 5ik1A-2m6kA:
undetectable		 5ik1A-2m6kA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nnj CYTOCHROME P450 2C8

(Homo sapiens) 		PF00067
(p450) 		4 THR A 301
VAL A 362
ILE A 476
VAL A 477
 HEM  A 500 ( 3.7A)
HEM  A 500 ( 4.9A)
225  A 501 ( 3.9A)
None
 0.71A 5ik1A-2nnjA:
30.1		 5ik1A-2nnjA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p91 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Aquifex
aeolicus) 		PF13561
(adh_short_C2) 		4 GLY A 241
VAL A 157
ILE A 102
VAL A 104
 None
 0.78A 5ik1A-2p91A:
undetectable		 5ik1A-2p91A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbe AMINOGLYCOSIDE
6-ADENYLYLTRANSFERAS
E

(Bacillus
subtilis) 		PF04439
(Adenyl_transf) 		4 PHE A  14
ASP A  18
ILE A  21
VAL A  49
 None
 0.79A 5ik1A-2pbeA:
1.7		 5ik1A-2pbeA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcn S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE

(Geobacillus
kaustophilus) 		PF03737
(RraA-like) 		4 GLY A  75
VAL A  90
ILE A 107
VAL A 109
 ACT  A 600 ( 4.4A)
None
None
None
 0.80A 5ik1A-2pcnA:
undetectable		 5ik1A-2pcnA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfk 6-PHOSPHOFRUCTOKINAS
E ISOZYME I

(Escherichia
coli) 		PF00365
(PFK) 		4 GLY A  22
VAL A  98
ILE A   4
VAL A   6
 None
 0.81A 5ik1A-2pfkA:
undetectable		 5ik1A-2pfkA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcz OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR YAET

(Escherichia
coli) 		PF07244
(POTRA) 		5 PHE A 197
THR A 243
ASP A 222
ILE A 180
VAL A 256
 None
 1.44A 5ik1A-2qczA:
undetectable		 5ik1A-2qczA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfl INOSITOL-1-MONOPHOSP
HATASE

(Escherichia
coli) 		PF00459
(Inositol_P) 		4 PHE A 230
GLY A 156
ILE A 171
VAL A 172
 None
 0.81A 5ik1A-2qflA:
undetectable		 5ik1A-2qflA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgn TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE

(Bacillus
halodurans) 		PF01715
(IPPT) 		5 PHE A 287
GLY A 307
VAL A   6
ILE A 195
VAL A 193
 None
 1.33A 5ik1A-2qgnA:
0.6		 5ik1A-2qgnA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkd ZINC FINGER PROTEIN
ZPR1

(Mus musculus) 		PF03367
(zf-ZPR1) 		4 GLY A 349
VAL A 273
ILE A 282
VAL A 281
 None
 0.79A 5ik1A-2qkdA:
undetectable		 5ik1A-2qkdA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qup BH1478 PROTEIN

(Bacillus
halodurans) 		PF03885
(DUF327) 		4 GLY A  78
VAL A 108
ILE A 104
VAL A 105
 None
 0.79A 5ik1A-2qupA:
2.0		 5ik1A-2qupA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvb HALOALKANE
DEHALOGENASE 3

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		4 GLY A 100
VAL A  60
ILE A  33
VAL A  34
 None
 0.77A 5ik1A-2qvbA:
undetectable		 5ik1A-2qvbA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2veo LIPASE A

(Moesziomyces
antarcticus) 		PF03583
(LIP) 		4 PHE A 431
GLY A 186
ILE A 336
VAL A 337
 None
 0.64A 5ik1A-2veoA:
undetectable		 5ik1A-2veoA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn8 RETICULON-4-INTERACT
ING PROTEIN 1

(Homo sapiens) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 GLY A 163
VAL A 127
ILE A  75
VAL A  76
 None
 0.74A 5ik1A-2vn8A:
undetectable		 5ik1A-2vn8A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy0 ENDO-BETA-1,3-GLUCAN
ASE

(Pyrococcus
furiosus) 		PF00722
(Glyco_hydro_16) 		4 GLY A 234
VAL A 136
ILE A 221
VAL A 222
 None
 0.81A 5ik1A-2vy0A:
undetectable		 5ik1A-2vy0A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Pseudomonas
aeruginosa) 		PF01370
(Epimerase) 		4 GLY A 194
ASP A 217
ILE A 216
VAL A 215
 None
 0.79A 5ik1A-2x4gA:
undetectable		 5ik1A-2x4gA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE

(Thermotoga
maritima) 		PF00483
(NTP_transferase) 		4 PHE A 168
VAL A 238
ASP A 239
VAL A 242
 None
 0.81A 5ik1A-2x60A:
undetectable		 5ik1A-2x60A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xet F1 CAPSULE-ANCHORING
PROTEIN

(Yersinia pestis) 		PF13953
(PapC_C) 		4 GLY A 761
VAL A 775
ILE A 743
VAL A 744
 SO4  A1090 (-3.5A)
None
None
None
 0.80A 5ik1A-2xetA:
undetectable		 5ik1A-2xetA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkr PUTATIVE CYTOCHROME
P450 142

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 GLY A 231
THR A 234
VAL A 277
VAL A 381
 HEM  A1400 (-3.2A)
HEM  A1400 (-3.7A)
HEM  A1400 (-4.5A)
None
 0.77A 5ik1A-2xkrA:
44.6		 5ik1A-2xkrA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfh GLUTAMATE
DEHYDROGENASE,
NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE,
GLUTAMATE
DEHYDROGENASE

(Escherichia
coli;
[Clostridium]
symbiosum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 GLY A 165
THR A 194
VAL A 162
ASP A 161
ILE A 156
 None
 1.37A 5ik1A-2yfhA:
undetectable		 5ik1A-2yfhA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygt DELTA TOXIN

(Clostridium
perfringens) 		PF07968
(Leukocidin) 		4 GLY A 130
THR A  60
VAL A 230
ASP A 108
 None
None
None
ZN  A1292 ( 4.5A)
 0.81A 5ik1A-2ygtA:
undetectable		 5ik1A-2ygtA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Thermus
thermophilus) 		PF00117
(GATase)
PF00958
(GMP_synt_C) 		4 GLY A  80
VAL A  92
ASP A 128
VAL A 130
 None
 0.81A 5ik1A-2ywbA:
undetectable		 5ik1A-2ywbA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Geobacillus
kaustophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 GLY A 137
VAL A 123
ILE A 119
VAL A 120
 None
 0.66A 5ik1A-2z01A:
undetectable		 5ik1A-2z01A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like) 		4 GLY A 370
VAL A 578
ILE A 339
VAL A 341
 None
 0.80A 5ik1A-3abzA:
undetectable		 5ik1A-3abzA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agr NUCLEOSIDE
TRIPHOSPHATE
HYDROLASE

(Neospora
caninum) 		PF01150
(GDA1_CD39) 		4 GLY A 213
VAL A 278
ILE A 296
VAL A 295
 None
 0.63A 5ik1A-3agrA:
undetectable		 5ik1A-3agrA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ap1 PROTEIN-TYROSINE
SULFOTRANSFERASE 2

(Homo sapiens) 		PF13469
(Sulfotransfer_3) 		4 THR A  82
ASP A 287
ILE A 290
VAL A 289
 A3P  A   1 (-3.6A)
None
None
A3P  A   1 (-3.8A)
 0.82A 5ik1A-3ap1A:
undetectable		 5ik1A-3ap1A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqo PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		no annotation 4 GLY A 156
VAL A 212
ILE A 206
VAL A 207
 None
 0.78A 5ik1A-3aqoA:
undetectable		 5ik1A-3aqoA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Thermotoga
maritima) 		PF02222
(ATP-grasp) 		4 GLY A  13
THR A  17
ILE A  28
VAL A  27
 None
 0.75A 5ik1A-3ax6A:
undetectable		 5ik1A-3ax6A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4u DIHYDRODIPICOLINATE
SYNTHASE

(Agrobacterium
fabrum) 		PF00701
(DHDPS) 		5 PHE A 244
GLY A 283
ASP A 277
ILE A 273
VAL A 252
 None
 1.50A 5ik1A-3b4uA:
undetectable		 5ik1A-3b4uA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcn ERVATAMIN-A

(Tabernaemontana
divaricata) 		PF00112
(Peptidase_C1) 		4 VAL A 102
ASP A  82
ILE A  81
VAL A 103
 None
 0.80A 5ik1A-3bcnA:
undetectable		 5ik1A-3bcnA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c41 AMINO ACID ABC
TRANSPORTER (ARTP)

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		5 PHE J 235
GLY J  39
VAL J 192
ILE J  33
VAL J  32
 None
ANP  J 601 (-3.2A)
None
None
None
 1.13A 5ik1A-3c41J:
undetectable		 5ik1A-3c41J:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ch7 6-PHOSPHOGLUCONOLACT
ONASE

(Leishmania
braziliensis) 		PF01182
(Glucosamine_iso) 		5 GLY A 251
VAL A 156
ASP A 157
ILE A 158
VAL A 159
 None
 1.34A 5ik1A-3ch7A:
undetectable		 5ik1A-3ch7A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00389
(2-Hacid_dh)
PF01842
(ACT)
PF02826
(2-Hacid_dh_C) 		4 THR A 222
VAL A 251
ILE A 227
VAL A 226
 None
 0.82A 5ik1A-3ddnA:
undetectable		 5ik1A-3ddnA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm0 MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH RACK1

(Escherichia
coli;
Arabidopsis
thaliana) 		PF00400
(WD40)
PF01547
(SBP_bac_1) 		4 GLY A1206
VAL A1178
ILE A1167
VAL A1168
 None
 0.76A 5ik1A-3dm0A:
undetectable		 5ik1A-3dm0A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dni DEOXYRIBONUCLEASE I

(Bos taurus) 		PF03372
(Exo_endo_phos) 		4 PHE A  11
VAL A  29
ILE A  25
VAL A  26
 None
 0.77A 5ik1A-3dniA:
undetectable		 5ik1A-3dniA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		4 GLY A 256
VAL A 344
ILE A 340
VAL A 341
 None
 0.81A 5ik1A-3du4A:
undetectable		 5ik1A-3du4A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8r THIOREDOXIN
REDUCTASE (TRXB-3)

(Sulfolobus
solfataricus) 		PF07992
(Pyr_redox_2) 		4 GLY A  24
VAL A  87
ILE A  44
VAL A  43
 NAP  A4005 (-3.3A)
None
None
None
 0.77A 5ik1A-3f8rA:
undetectable		 5ik1A-3f8rA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzu IMMUNOGLOBULIN IGG1
FAB, HEAVY CHAIN

(Homo sapiens) 		no annotation 5 PHE H 127
GLY H 123
THR H 210
VAL H 203
VAL H 212
 None
 1.40A 5ik1A-3fzuH:
undetectable		 5ik1A-3fzuH:
18.50