SIMILAR PATTERNS OF AMINO ACIDS FOR 5IK1_A_CAMA502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg1 ENDOGLUCANASE I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		4 PHE A 130
LEU A 134
GLY A 202
ILE A 199
 None
 1.00A 5ik1A-1eg1A:
0.0		 5ik1A-1eg1A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PHE A 446
LEU A 404
GLY A 533
ILE A 456
 None
 0.78A 5ik1A-1kcwA:
0.0		 5ik1A-1kcwA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 CYTOCHROME B6F
COMPLEX SUBUNIT PETL
CYTOCHROME B6-F
COMPLEX IRON-SULFUR
SUBUNIT

(Chlamydomonas
reinhardtii;
Chlamydomonas
reinhardtii) 		PF05115
(PetL)
PF08802
(CytB6-F_Fe-S) 		4 PHE L  17
LEU R  55
GLY R  52
ILE L  21
 None
 1.02A 5ik1A-1q90L:
undetectable		 5ik1A-1q90L:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjs HEMOPEXIN

(Oryctolagus
cuniculus) 		PF00045
(Hemopexin) 		4 PHE A 138
LEU A 149
GLY A 152
ILE A 116
 None
 1.01A 5ik1A-1qjsA:
undetectable		 5ik1A-1qjsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0j DNA REPLICATION
PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF01057
(Parvo_NS1) 		4 PHE A 316
LEU A 450
GLY A 339
ILE A 347
 None
None
ADP  A 491 (-3.3A)
None
 1.01A 5ik1A-1u0jA:
0.0		 5ik1A-1u0jA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE

(Pyrococcus
horikoshii) 		PF04587
(ADP_PFK_GK) 		4 PHE A 242
GLY A 234
ASP A 268
ILE A 269
 None
 1.00A 5ik1A-1u2xA:
0.0		 5ik1A-1u2xA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc7 THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBD

(Escherichia
coli) 		PF13899
(Thioredoxin_7) 		4 LEU A  81
GLY A  88
ASP A  34
ILE A  92
 None
 0.95A 5ik1A-1uc7A:
undetectable		 5ik1A-1uc7A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wg6 HYPOTHETICAL PROTEIN
(RIKEN CDNA
2810455B10)

(Mus musculus) 		PF00595
(PDZ) 		4 LEU A  89
GLY A  56
ASP A  78
ILE A  59
 None
 1.00A 5ik1A-1wg6A:
undetectable		 5ik1A-1wg6A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wky ENDO-BETA-1,4-MANNAN
ASE

(Bacillus sp.
JAMB-602) 		PF00150
(Cellulase) 		4 PHE A 254
LEU A 319
GLY A 318
ILE A 268
 None
 1.01A 5ik1A-1wkyA:
0.0		 5ik1A-1wkyA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yll CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF05962
(HutD) 		4 PHE A  53
LEU A 101
GLY A  70
ILE A  63
 None
 1.01A 5ik1A-1yllA:
0.0		 5ik1A-1yllA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z63 HELICASE OF THE
SNF2/RAD54 FAMILY

(Sulfolobus
solfataricus) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 LEU A 467
GLY A 451
ASP A 653
ILE A 656
 None
 1.02A 5ik1A-1z63A:
undetectable		 5ik1A-1z63A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8t ARGONAUTE PROTEIN

(Aquifex
aeolicus) 		PF02171
(Piwi) 		4 PHE A 560
GLY A 526
ASP A 496
ILE A 566
 None
 1.00A 5ik1A-2f8tA:
undetectable		 5ik1A-2f8tA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN

(Homo sapiens) 		PF05971
(Methyltransf_10) 		4 PHE A 143
GLY A  89
ASP A 142
ILE A  56
 None
 0.90A 5ik1A-2h00A:
undetectable		 5ik1A-2h00A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB

(Methanocaldococcus
jannaschii) 		PF02492
(cobW) 		4 LEU A  48
GLY A  45
ASP A 170
ILE A 169
 GSP  A 300 (-4.3A)
GSP  A 300 (-3.2A)
GSP  A 300 (-2.9A)
None
 0.89A 5ik1A-2hf8A:
undetectable		 5ik1A-2hf8A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)

(Homo sapiens) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 PHE A 239
LEU A 103
ASP A 268
ILE A 209
 None
 0.86A 5ik1A-2hgsA:
undetectable		 5ik1A-2hgsA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l89 PWWP
DOMAIN-CONTAINING
PROTEIN 1

(Schizosaccharomyces
pombe) 		PF00855
(PWWP) 		4 PHE A  95
LEU A  71
GLY A  53
ASP A 142
 None
 0.95A 5ik1A-2l89A:
undetectable		 5ik1A-2l89A:
14.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		5 PHE A  87
LEU A 244
GLY A 248
ASP A 297
ILE A 395
 CAM  A 502 (-4.6A)
HEM  A 501 (-4.5A)
HEM  A 501 (-3.9A)
HEM  A 501 (-2.8A)
None
 0.87A 5ik1A-2m56A:
58.0		 5ik1A-2m56A:
99.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nly DIVERGENT
POLYSACCHARIDE
DEACETYLASE
HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF04748
(Polysacc_deac_2) 		4 PHE A 239
LEU A 188
GLY A 217
ILE A 244
 None
 0.94A 5ik1A-2nlyA:
undetectable		 5ik1A-2nlyA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00275
(EPSP_synthase) 		4 PHE A 415
LEU A 395
GLY A 394
ILE A 405
 None
 1.02A 5ik1A-2o0xA:
undetectable		 5ik1A-2o0xA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ovl PUTATIVE RACEMASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 126
GLY A 116
ASP A 108
ILE A 109
 None
 0.93A 5ik1A-2ovlA:
undetectable		 5ik1A-2ovlA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p18 GLYOXALASE II

(Leishmania
infantum) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		4 LEU A 145
GLY A 163
ASP A 109
ILE A 111
 None
 1.01A 5ik1A-2p18A:
undetectable		 5ik1A-2p18A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo4 LIVER-BASIC FATTY
ACID BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		4 PHE A   2
LEU A  84
GLY A  86
ILE A 102
 None
 0.97A 5ik1A-2qo4A:
undetectable		 5ik1A-2qo4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wc1 FLAVODOXIN

(Rhodobacter
capsulatus) 		PF00258
(Flavodoxin_1) 		4 PHE A 176
LEU A  94
GLY A  54
ILE A   4
 None
 0.98A 5ik1A-2wc1A:
undetectable		 5ik1A-2wc1A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whl BETA-MANNANASE

(Salipaludibacillus
agaradhaerens) 		PF00150
(Cellulase) 		4 PHE A 223
LEU A 288
GLY A 287
ILE A 237
 None
 0.99A 5ik1A-2whlA:
undetectable		 5ik1A-2whlA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU C 101
GLY C 196
ASP C 237
ILE C 177
 None
 0.83A 5ik1A-2wtkC:
undetectable		 5ik1A-2wtkC:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypj ENDOGLUCANASE CEL5A

([Eubacterium]
cellulosolvens) 		no annotation 4 PHE A 643
LEU A 590
GLY A 704
ILE A 671
 None
 0.87A 5ik1A-2ypjA:
undetectable		 5ik1A-2ypjA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z95 GDP-D-MANNOSE
DEHYDRATASE

(Aquifex
aeolicus) 		PF16363
(GDP_Man_Dehyd) 		4 PHE A 266
GLY A 205
ASP A 281
ILE A 288
 None
 0.98A 5ik1A-2z95A:
undetectable		 5ik1A-2z95A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 PHE A 610
LEU A 659
GLY A 594
ILE A 571
 None
 1.02A 5ik1A-3a24A:
undetectable		 5ik1A-3a24A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 PHE A 237
LEU A 190
GLY A 181
ILE A 295
 None
None
HTL  A 827 (-3.3A)
None
 0.81A 5ik1A-3ahiA:
undetectable		 5ik1A-3ahiA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 PHE A 237
LEU A 190
GLY A 181
ILE A 295
 None
None
TPP  A 900 (-3.2A)
None
 0.79A 5ik1A-3ai7A:
undetectable		 5ik1A-3ai7A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4u DIHYDRODIPICOLINATE
SYNTHASE

(Agrobacterium
fabrum) 		PF00701
(DHDPS) 		4 PHE A 244
GLY A 283
ASP A 277
ILE A 273
 None
 0.96A 5ik1A-3b4uA:
undetectable		 5ik1A-3b4uA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		4 PHE A 169
LEU A 297
GLY A 259
ILE A 128
 None
 0.77A 5ik1A-3blwA:
undetectable		 5ik1A-3blwA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw8 RETICULINE OXIDASE

(Eschscholzia
californica) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 LEU A  99
GLY A 225
ASP A 505
ILE A 504
 FAD  A   1 (-4.4A)
FAD  A   1 (-3.4A)
None
None
 1.01A 5ik1A-3fw8A:
undetectable		 5ik1A-3fw8A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jug BETA-MANNANASE

(Bacillus sp.
N16-5) 		PF00150
(Cellulase) 		4 PHE A 254
LEU A 319
GLY A 318
ILE A 268
 None
 0.99A 5ik1A-3jugA:
undetectable		 5ik1A-3jugA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kol GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Nostoc
punctiforme) 		PF00903
(Glyoxalase) 		4 PHE A 138
LEU A  43
GLY A  42
ILE A 116
 None
 0.97A 5ik1A-3kolA:
undetectable		 5ik1A-3kolA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE

(Exiguobacterium
sibiricum) 		PF01212
(Beta_elim_lyase) 		4 PHE A  51
LEU A 207
GLY A 209
ILE A 243
 None
 0.88A 5ik1A-3lwsA:
undetectable		 5ik1A-3lwsA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6i L-ARABINITOL
4-DEHYDROGENASE

(Neurospora
crassa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PHE A 344
LEU A 337
GLY A  11
ASP A  56
 None
 1.02A 5ik1A-3m6iA:
undetectable		 5ik1A-3m6iA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF00385
(Chromo) 		4 LEU W 673
GLY W 689
ASP W 729
ILE W 726
 None
 1.00A 5ik1A-3mwyW:
undetectable		 5ik1A-3mwyW:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nk7 23S RRNA
METHYLTRANSFERASE

(Streptomyces
actuosus) 		PF00588
(SpoU_methylase)
PF04705
(TSNR_N) 		4 PHE A  50
LEU A 161
GLY A 166
ILE A  44
 None
 0.98A 5ik1A-3nk7A:
undetectable		 5ik1A-3nk7A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppc 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Candida
albicans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 PHE A  95
LEU A  18
GLY A  39
ILE A  91
 None
None
None
CL  A 768 ( 4.2A)
 1.00A 5ik1A-3ppcA:
0.7		 5ik1A-3ppcA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgh RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		4 PHE A 551
GLY A 543
ASP A 458
ILE A 462
 63F  A 601 (-4.3A)
None
None
63F  A 601 (-4.0A)
 0.78A 5ik1A-3qghA:
undetectable		 5ik1A-3qghA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PHE A 217
LEU A 202
GLY A 249
ILE A 192
 None
 1.01A 5ik1A-3r44A:
undetectable		 5ik1A-3r44A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 PHE A 294
LEU A 310
GLY A 312
ILE A 317
 None
 0.97A 5ik1A-3rg1A:
undetectable		 5ik1A-3rg1A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20

(Saccharomyces
cerevisiae) 		PF03070
(TENA_THI-4)
PF08543
(Phos_pyr_kin) 		4 PHE A 372
LEU A 476
ASP A 376
ILE A 373
 None
 1.00A 5ik1A-3rm5A:
1.1		 5ik1A-3rm5A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwx HYPOTHETICAL
BACTERIAL OUTER
MEMBRANE PROTEIN

(Bacteroides
fragilis) 		PF13944
(Calycin_like) 		4 PHE A 266
LEU A 165
GLY A 198
ILE A 247
 MLY  A 267 ( 4.6A)
None
MLY  A 197 ( 2.4A)
MLY  A 267 ( 4.4A)
 0.99A 5ik1A-3rwxA:
undetectable		 5ik1A-3rwxA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqd PAX-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF16770
(RTT107_BRCT_5) 		4 PHE A 978
LEU A 972
GLY A1055
ILE A1027
 None
 0.98A 5ik1A-3sqdA:
undetectable		 5ik1A-3sqdA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssz MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Rhodobacteraceae
bacterium KLH11) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 300
GLY A 288
ASP A 269
ILE A 267
 None
 0.90A 5ik1A-3sszA:
undetectable		 5ik1A-3sszA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stp GALACTONATE
DEHYDRATASE,
PUTATIVE

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 277
GLY A 265
ASP A 246
ILE A 244
 None
 0.91A 5ik1A-3stpA:
undetectable		 5ik1A-3stpA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx8 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Corynebacterium
glutamicum) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A 163
GLY A 164
ASP A  79
ILE A  78
 None
 1.01A 5ik1A-3tx8A:
undetectable		 5ik1A-3tx8A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uvf INTRON-ENCODED DNA
ENDONUCLEASE I-HJEMI

(Trichoderma
reesei) 		PF00961
(LAGLIDADG_1) 		4 LEU A 225
GLY A 227
ASP A  18
ILE A  36
 None
None
CA  A 301 ( 2.6A)
None
 0.93A 5ik1A-3uvfA:
undetectable		 5ik1A-3uvfA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vil BETA-GLUCOSIDASE

(Neotermes
koshunensis) 		PF00232
(Glyco_hydro_1) 		4 PHE A 317
LEU A 296
GLY A 279
ILE A 325
 None
 0.99A 5ik1A-3vilA:
undetectable		 5ik1A-3vilA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsj 2-AMINO-5-CHLOROPHEN
OL 1,6-DIOXYGENASE
BETA SUBUNIT

(Comamonas
testosteroni) 		PF02900
(LigB) 		4 LEU B  37
GLY B 275
ASP B 222
ILE B 223
 None
 1.02A 5ik1A-3vsjB:
undetectable		 5ik1A-3vsjB:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg4 ERFK/YBIS/YCFS/YNHG

(Enterococcus
faecium) 		PF03734
(YkuD) 		4 PHE A 382
GLY A 371
ASP A 414
ILE A 413
 None
 0.97A 5ik1A-3zg4A:
undetectable		 5ik1A-3zg4A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF00111
(Fer2)
PF14574
(DUF4445) 		4 PHE X 375
GLY X 577
ASP X 377
ILE X 357
 None
None
MG  X 802 ( 4.0A)
None
 0.84A 5ik1A-3zyyX:
undetectable		 5ik1A-3zyyX:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE

(Bacteroides
ovatus) 		PF03414
(Glyco_transf_6) 		4 PHE A  94
LEU A 118
GLY A 161
ILE A   5
 None
 0.85A 5ik1A-4ayjA:
undetectable		 5ik1A-4ayjA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 PHE B2605
LEU B2581
GLY B2589
ILE B2508
 None
 1.01A 5ik1A-4bedB:
0.9		 5ik1A-4bedB:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bnq NON-CANONICAL PURINE
NTP PYROPHOSPHATASE

(Staphylococcus
aureus) 		PF01725
(Ham1p_like) 		4 PHE A  17
GLY A 133
ASP A  16
ILE A  20
 None
 0.97A 5ik1A-4bnqA:
undetectable		 5ik1A-4bnqA:
17.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 LEU A 252
GLY A 256
ASP A 305
ILE A 403
 HEM  A1418 (-4.0A)
HEM  A1418 (-3.8A)
HEM  A1418 (-2.7A)
None
 0.62A 5ik1A-4c9mA:
52.4		 5ik1A-4c9mA:
44.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 PHE A  87
LEU A 250
GLY A 254
ILE A 401
 None
HEM  A 501 (-4.3A)
PEG  A 502 (-3.8A)
None
 0.35A 5ik1A-4dxyA:
55.3		 5ik1A-4dxyA:
46.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		4 PHE A 382
LEU A 374
GLY A 372
ILE A 468
 None
 0.70A 5ik1A-4ecnA:
undetectable		 5ik1A-4ecnA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvf GREEN FLUORESCENT
PROTEIN BLFP-Y6

(Branchiostoma
lanceolatum) 		PF01353
(GFP) 		4 PHE A  61
LEU A  39
GLY A  24
ILE A 112
 CR2  A  58 ( 3.5A)
None
None
None
 0.94A 5ik1A-4hvfA:
undetectable		 5ik1A-4hvfA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2w PROTEIN UNC-45

(Caenorhabditis
elegans) 		PF11701
(UNC45-central) 		4 LEU A 455
GLY A 458
ASP A 545
ILE A 546
 None
 0.74A 5ik1A-4i2wA:
undetectable		 5ik1A-4i2wA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igb LPXTG CELL WALL
SURFACE PROTEIN

(Streptococcus
gordonii) 		no annotation 4 PHE D 162
LEU D  56
GLY D 307
ILE D 175
 None
 1.00A 5ik1A-4igbD:
undetectable		 5ik1A-4igbD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igi COLLAGEN ALPHA3(VI)

(Mus musculus) 		PF00092
(VWA) 		4 PHE A1188
LEU A1097
GLY A1033
ILE A1164
 None
 1.01A 5ik1A-4igiA:
undetectable		 5ik1A-4igiA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4

(Saccharopolyspora
spinosa) 		PF08659
(KR) 		4 PHE A 506
LEU A 216
GLY A 420
ILE A 473
 None
 0.91A 5ik1A-4impA:
undetectable		 5ik1A-4impA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwm UPF0135 PROTEIN
MJ0927

(Methanocaldococcus
jannaschii) 		PF01784
(NIF3) 		4 PHE A  68
LEU A 113
GLY A 112
ILE A  15
 None
 1.01A 5ik1A-4iwmA:
undetectable		 5ik1A-4iwmA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jge RED FLUORESCENT
PROTEIN BLFP-R5

(Branchiostoma
lanceolatum) 		PF01353
(GFP) 		4 PHE A  61
LEU A  39
GLY A  24
ILE A 112
 CR2  A  58 ( 3.6A)
None
None
None
 0.95A 5ik1A-4jgeA:
undetectable		 5ik1A-4jgeA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1k D-ALANINE--D-ALANINE
LIGASE

(Xanthomonas
oryzae) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 PHE A 322
LEU A 234
GLY A 297
ILE A 105
 None
 0.93A 5ik1A-4l1kA:
undetectable		 5ik1A-4l1kA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lb0 UNCHARACTERIZED
PROTEIN

(Agrobacterium
vitis) 		PF05544
(Pro_racemase) 		4 PHE A  81
LEU A 144
GLY A 256
ILE A  83
 None
None
ACT  A 401 (-3.6A)
None
 0.96A 5ik1A-4lb0A:
undetectable		 5ik1A-4lb0A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Verminephrobacter
eiseniae) 		PF13458
(Peripla_BP_6) 		4 LEU A 107
GLY A 100
ASP A  50
ILE A   7
 None
 0.84A 5ik1A-4m88A:
undetectable		 5ik1A-4m88A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		4 PHE A 453
LEU A 425
GLY A 378
ILE A 302
 None
 0.91A 5ik1A-4mk0A:
2.1		 5ik1A-4mk0A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nlm LMO1340 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 PHE A  47
GLY A  52
ASP A 342
ILE A 356
 None
 1.01A 5ik1A-4nlmA:
undetectable		 5ik1A-4nlmA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npk EXTENDED
SYNAPTOTAGMIN-2

(Homo sapiens) 		PF00168
(C2) 		4 PHE A 391
LEU A 397
GLY A 470
ILE A 418
 None
 0.93A 5ik1A-4npkA:
undetectable		 5ik1A-4npkA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oet PUTATIVE PEPTIDE
ABC-TRANSPORT SYSTEM
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF00496
(SBP_bac_5) 		4 PHE A 104
LEU A  37
GLY A  36
ILE A 100
 None
 0.86A 5ik1A-4oetA:
undetectable		 5ik1A-4oetA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p42 EXTENDED
SYNAPTOTAGMIN-2

(Homo sapiens) 		PF00168
(C2)
PF17047
(SMP_LBD) 		4 PHE A 363
LEU A 369
GLY A 442
ILE A 390
 None
 0.90A 5ik1A-4p42A:
undetectable		 5ik1A-4p42A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p52 HOMOSERINE KINASE

(Cytophaga
hutchinsonii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 PHE A 242
LEU A 250
GLY A 256
ILE A 259
 None
 0.81A 5ik1A-4p52A:
1.3		 5ik1A-4p52A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2h PROLINE RACEMASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF05544
(Pro_racemase) 		4 PHE A  81
LEU A 144
GLY A 256
ILE A  83
 None
None
CSO  A 255 (-2.4A)
None
 0.97A 5ik1A-4q2hA:
undetectable		 5ik1A-4q2hA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 PHE A 634
LEU A 610
GLY A 566
ILE A 489
 None
 0.86A 5ik1A-4q9zA:
undetectable		 5ik1A-4q9zA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		4 LEU A  73
GLY A 169
ASP A 207
ILE A 150
 None
ANP  A 402 ( 3.8A)
None
None
 0.90A 5ik1A-4qnyA:
undetectable		 5ik1A-4qnyA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uc7 NUCLEOPROTEIN

(Human
orthopneumovirus) 		PF03246
(Pneumo_ncap) 		4 PHE A 213
LEU A 161
GLY A 227
ILE A 220
 None
 1.02A 5ik1A-4uc7A:
undetectable		 5ik1A-4uc7A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uz1 NOTUM

(Homo sapiens) 		PF03283
(PAE) 		4 PHE A 179
LEU A 146
GLY A 127
ILE A 393
 None
 1.02A 5ik1A-4uz1A:
undetectable		 5ik1A-4uz1A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xai MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TAILLESS
ORTHOLOG

(Escherichia
coli;
Tribolium
castaneum) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		4 PHE A1280
LEU A1248
GLY A1243
ILE A1369
 None
 0.86A 5ik1A-4xaiA:
1.8		 5ik1A-4xaiA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjv S-ACYL FATTY ACID
SYNTHASE
THIOESTERASE, MEDIUM
CHAIN

(Homo sapiens) 		PF00975
(Thioesterase) 		4 PHE A  32
LEU A 114
GLY A 113
ILE A 106
 None
 0.96A 5ik1A-4xjvA:
undetectable		 5ik1A-4xjvA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		4 PHE A 477
LEU A 521
GLY A 564
ILE A 480
 None
 0.84A 5ik1A-4zhjA:
undetectable		 5ik1A-4zhjA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afe ENDOGLUCANASE CEL5A

([Eubacterium]
cellulosolvens) 		no annotation 4 PHE A 643
LEU A 590
GLY A 704
ILE A 671
 None
 0.86A 5ik1A-5afeA:
undetectable		 5ik1A-5afeA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewo STRUCTURAL PROTEIN

(Mamastrovirus 1) 		PF12226
(Astro_capsid_p) 		4 PHE A 438
LEU A 626
GLY A 480
ILE A 484
 None
 1.01A 5ik1A-5ewoA:
undetectable		 5ik1A-5ewoA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540

(Arabidopsis
thaliana) 		PF13855
(LRR_8) 		4 PHE B 317
LEU B 288
GLY B 283
ILE B 302
 None
 0.95A 5ik1A-5hz1B:
undetectable		 5ik1A-5hz1B:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ioo AVPA

(Nanoarchaeota
archaeon JGI
OTU-1) 		no annotation 4 LEU A 175
GLY A  62
ASP A 119
ILE A 118
 None
 0.97A 5ik1A-5iooA:
undetectable		 5ik1A-5iooA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwa PROTEASOME-ASSOCIATE
D ATPASE

(Mycobacterium
tuberculosis) 		PF00004
(AAA)
PF16450
(Prot_ATP_ID_OB) 		4 PHE A 353
LEU A 431
GLY A 413
ILE A 352
 None
 0.97A 5ik1A-5kwaA:
undetectable		 5ik1A-5kwaA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwa PROTEASOME-ASSOCIATE
D ATPASE

(Mycobacterium
tuberculosis) 		PF00004
(AAA)
PF16450
(Prot_ATP_ID_OB) 		4 PHE A 377
LEU A 290
GLY A 413
ILE A 376
 None
 0.96A 5ik1A-5kwaA:
undetectable		 5ik1A-5kwaA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltq GREEN FLUORESCENT
PROTEIN BLFP-Y3

(Branchiostoma
lanceolatum) 		PF01353
(GFP) 		4 PHE A  61
LEU A  39
GLY A  24
ILE A 111
 CR2  A  59 ( 3.6A)
None
None
None
 0.96A 5ik1A-5ltqA:
undetectable		 5ik1A-5ltqA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC

(synthetic
construct) 		no annotation 4 PHE D  71
LEU D  49
GLY D  34
ILE D 121
 CR2  D  70 ( 3.5A)
None
None
None
 1.00A 5ik1A-5mwcD:
undetectable		 5ik1A-5mwcD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1

(Alicyclobacillus
acidoterrestris) 		no annotation 4 PHE A 472
LEU A 560
GLY A 556
ASP A 465
 None
 0.89A 5ik1A-5u30A:
undetectable		 5ik1A-5u30A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 PHE A 453
LEU A 425
GLY A 378
ILE A 302
 None
 0.88A 5ik1A-5uuuA:
undetectable		 5ik1A-5uuuA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwl CENTROMERE PROTEIN
MIS12
KINETOCHORE PROTEIN
NNF1

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		no annotation
no annotation 		4 PHE N  32
LEU N  48
GLY M  31
ILE M  49
 None
 0.97A 5ik1A-5wwlN:
undetectable		 5ik1A-5wwlN:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zic -

(-) 		no annotation 4 PHE A 235
LEU A 276
GLY A 275
ILE A 317
 None
 1.02A 5ik1A-5zicA:
undetectable		 5ik1A-5zicA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zov -

(-) 		no annotation 4 PHE A 385
LEU A 343
GLY A 342
ILE A 335
 None
 0.91A 5ik1A-5zovA:
undetectable		 5ik1A-5zovA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zut PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A  12
LEU A  68
GLY A  69
ILE A  16
 None
 1.02A 5ik1A-5zutA:
undetectable		 5ik1A-5zutA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b92 U6 SMALL NUCLEAR RNA
(ADENINE-(43)-N(6))-
METHYLTRANSFERASE

(Homo sapiens) 		no annotation 4 PHE A 180
GLY A 126
ASP A 179
ILE A  93
 None
 0.82A 5ik1A-6b92A:
undetectable		 5ik1A-6b92A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bgi ANOCTAMIN-1

(Mus musculus) 		no annotation 4 PHE A 581
LEU A 711
GLY A 764
ILE A 759
 None
 0.93A 5ik1A-6bgiA:
1.1		 5ik1A-6bgiA:
undetectable