SIMILAR PATTERNS OF AMINO ACIDS FOR 5IH0_A_ERYA404_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4p PROTEIN (GLUTATHIONE
S-TRANSFERASE)

(Rattus
norvegicus) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 ASP A 161
HIS A  14
ILE A  16
TYR A   6
 None
 1.28A 5ih0A-1b4pA:
0.0		 5ih0A-1b4pA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cs3 ZINC FINGER PROTEIN
PLZF

(Homo sapiens) 		PF00651
(BTB) 		4 TYR A  88
ASP A  35
HIS A  48
ILE A  38
 None
 1.19A 5ih0A-1cs3A:
undetectable		 5ih0A-1cs3A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 ASP A  63
ILE A  57
TYR A  18
TYR A 388
 None
 1.23A 5ih0A-1dedA:
0.0		 5ih0A-1dedA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fob BETA-1,4-GALACTANASE

(Aspergillus
aculeatus) 		PF07745
(Glyco_hydro_53) 		4 ASP A  79
HIS A  81
ILE A 137
TYR A 215
 None
 1.04A 5ih0A-1fobA:
0.0		 5ih0A-1fobA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE

(Escherichia
virus Lambda) 		PF00149
(Metallophos) 		4 ASP A  20
HIS A 139
ILE A 183
TYR A 200
 MN  A1006 (-3.4A)
MN  A1005 (-3.4A)
None
None
 1.24A 5ih0A-1g5bA:
0.0		 5ih0A-1g5bA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtu GLUTATHIONE
S-TRANSFERASE

(Homo sapiens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ASP A 161
HIS A  14
ILE A  16
TYR A   6
 None
 1.24A 5ih0A-1gtuA:
0.0		 5ih0A-1gtuA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hh4 RHO GDP-DISSOCIATION
INHIBITOR 1

(Homo sapiens) 		PF02115
(Rho_GDI) 		4 ASP D 440
ILE D 429
TYR D 428
TYR D 410
 None
None
None
GER  D1502 (-4.9A)
 1.25A 5ih0A-1hh4D:
0.0		 5ih0A-1hh4D:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8t UDP-GALACTOPYRANOSE
MUTASE

(Escherichia
coli) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 TYR A 346
ILE A  57
TYR A 181
TYR A 151
 FAD  A 450 (-4.7A)
FAD  A 450 (-4.1A)
None
None
 0.95A 5ih0A-1i8tA:
0.0		 5ih0A-1i8tA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1noz DNA POLYMERASE

(Escherichia
virus T4) 		PF03104
(DNA_pol_B_exo1) 		4 TYR A 198
ASP A 137
HIS A 135
ILE A 184
 None
 1.23A 5ih0A-1nozA:
0.3		 5ih0A-1nozA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nx8 CARBAPENEM SYNTHASE

(Pectobacterium
carotovorum) 		PF02668
(TauD) 		4 TYR A 232
ASP A 240
HIS A 234
ILE A 243
 None
 1.19A 5ih0A-1nx8A:
undetectable		 5ih0A-1nx8A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otw COENZYME PQQ
SYNTHESIS PROTEIN C

(Klebsiella
pneumoniae) 		PF03070
(TENA_THI-4) 		4 TYR A 128
ASP A 186
ILE A  81
TYR A 175
 PQQ  A 500 (-4.6A)
None
None
PQQ  A 500 (-4.3A)
 1.30A 5ih0A-1otwA:
undetectable		 5ih0A-1otwA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pex COLLAGENASE-3

(Homo sapiens) 		PF00045
(Hemopexin) 		4 HIS A 337
ILE A 340
TYR A 332
TYR A 400
 None
 1.16A 5ih0A-1pexA:
undetectable		 5ih0A-1pexA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r47 ALPHA-GALACTOSIDASE
A

(Homo sapiens) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		4 ASP A 264
HIS A 225
ILE A 219
TYR A 184
 None
 1.20A 5ih0A-1r47A:
2.8		 5ih0A-1r47A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0b THUA-LIKE PROTEIN

(Geobacillus
stearothermophilus) 		PF06283
(ThuA) 		4 ASP A  19
HIS A  15
ILE A  25
TYR A 202
 None
 1.09A 5ih0A-1t0bA:
undetectable		 5ih0A-1t0bA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tw9 GLUTATHIONE
S-TRANSFERASE 2

(Heligmosomoides
polygyrus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 TYR A  98
ASP A 166
HIS A 163
ILE A 175
 None
 1.11A 5ih0A-1tw9A:
undetectable		 5ih0A-1tw9A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v33 DNA PRIMASE SMALL
SUBUNIT

(Pyrococcus
horikoshii) 		PF01896
(DNA_primase_S) 		4 TYR A 307
ASP A 140
HIS A 142
ILE A 152
 None
 1.19A 5ih0A-1v33A:
undetectable		 5ih0A-1v33A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w66 LIPOYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF03099
(BPL_LplA_LipB) 		4 TYR A  91
HIS A 157
ILE A 146
TYR A 105
 DKA  A 301 (-4.9A)
None
None
None
 1.28A 5ih0A-1w66A:
undetectable		 5ih0A-1w66A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzw PURPLE ACID
PHOSPHATASE

(Ipomoea batatas) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		4 TYR A 166
HIS A 324
ILE A 358
TYR A 252
 FE  A 429 ( 4.3A)
FE  A 429 ( 3.9A)
None
None
 1.29A 5ih0A-1xzwA:
undetectable		 5ih0A-1xzwA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zs8 HISTOCOMPATIBILITY
2, M REGION LOCUS
10.5

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 117
ASP A  90
HIS A  92
ILE A  11
 None
 1.20A 5ih0A-1zs8A:
undetectable		 5ih0A-1zs8A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axo HYPOTHETICAL PROTEIN
ATU2684

(Agrobacterium
fabrum) 		PF06764
(DUF1223) 		4 TYR A 114
ASP A 124
HIS A 125
ILE A 134
 None
 1.24A 5ih0A-2axoA:
undetectable		 5ih0A-2axoA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi7 UDP-GALACTOPYRANOSE
MUTASE

(Klebsiella
pneumoniae) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 TYR A 349
ILE A  61
TYR A 185
TYR A 155
 FAD  A1385 (-4.8A)
FAD  A1385 (-4.3A)
None
None
 1.00A 5ih0A-2bi7A:
undetectable		 5ih0A-2bi7A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csu 457AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF13380
(CoA_binding_2)
PF13607
(Succ_CoA_lig) 		4 ASP A 187
HIS A 118
ILE A 116
TYR A   4
 None
 1.25A 5ih0A-2csuA:
undetectable		 5ih0A-2csuA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjv ATP-DEPENDENT RNA
HELICASE DBPA

(Bacillus
subtilis) 		PF00271
(Helicase_C) 		4 TYR A 265
ASP A 233
ILE A 313
TYR A 315
 None
 1.19A 5ih0A-2hjvA:
undetectable		 5ih0A-2hjvA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2if5 ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 7A

(Homo sapiens) 		PF00651
(BTB) 		4 TYR A  92
ASP A  34
HIS A  47
ILE A  37
 None
 1.22A 5ih0A-2if5A:
undetectable		 5ih0A-2if5A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT
TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT

(Pseudomonas
stutzeri;
Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS)
PF02332
(Phenol_Hydrox) 		4 ASP A  66
ILE A  61
TYR A  58
TYR B 157
 None
 1.22A 5ih0A-2incA:
undetectable		 5ih0A-2incA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j64 FICOLIN-3

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		4 HIS A 172
ILE A 170
TYR A 177
TYR A  72
 None
 1.06A 5ih0A-2j64A:
undetectable		 5ih0A-2j64A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz G2/MITOTIC-SPECIFIC
CYCLIN-B1

(Homo sapiens) 		PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		4 HIS B 320
ILE B 412
TYR B 404
TYR B 224
 None
 1.23A 5ih0A-2jgzB:
undetectable		 5ih0A-2jgzB:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		4 ASP A 138
HIS A  66
TYR A 127
TYR A 266
 SO4  A1776 ( 4.7A)
SO4  A1776 (-4.2A)
None
SO4  A1776 (-4.8A)
 1.24A 5ih0A-2nsmA:
undetectable		 5ih0A-2nsmA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9t DING

(Pseudomonas
fluorescens) 		PF12849
(PBP_like_2) 		4 TYR A 301
HIS A  57
ILE A 296
TYR A  73
 None
 1.25A 5ih0A-2q9tA:
undetectable		 5ih0A-2q9tA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vat ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE

(Acremonium
chrysogenum) 		PF00561
(Abhydrolase_1) 		4 TYR A 336
ASP A 302
ILE A 123
TYR A 294
 None
 1.03A 5ih0A-2vatA:
undetectable		 5ih0A-2vatA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdu TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE-ASSOCI
ATED WD REPEAT
PROTEIN TRM82

(Saccharomyces
cerevisiae) 		no annotation 4 ASP B 234
HIS B 226
ILE B 204
TYR B 253
 None
 1.23A 5ih0A-2vduB:
1.4		 5ih0A-2vduB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg8 HYDROQUINONE
GLUCOSYLTRANSFERASE

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		4 TYR A 315
ASP A 117
HIS A  19
ILE A  21
 EDO  A1480 (-4.8A)
None
EDO  A1480 ( 3.8A)
UDP  A1477 (-3.7A)
 1.20A 5ih0A-2vg8A:
undetectable		 5ih0A-2vg8A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 TYR A 136
ASP A 109
ILE A  88
TYR A 128
 None
 1.25A 5ih0A-2z81A:
undetectable		 5ih0A-2z81A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 ASP A  63
ILE A  57
TYR A  18
TYR A 388
 None
 1.13A 5ih0A-3bmwA:
undetectable		 5ih0A-3bmwA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli) 		PF10672
(Methyltrans_SAM) 		4 TYR A 387
ASP A 375
HIS A 376
ILE A 105
 None
 1.29A 5ih0A-3c0kA:
undetectable		 5ih0A-3c0kA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dan CYTOCHROME P450 74A2

(Parthenium
argentatum) 		PF00067
(p450) 		4 TYR A 237
ASP A 263
HIS A 267
ILE A 269
 None
 1.08A 5ih0A-3danA:
undetectable		 5ih0A-3danA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg2 PUTATIVE RUBREDOXIN
REDUCTASE

(Rhodopseudomonas
palustris) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		4 TYR P 203
ASP P 192
HIS P 191
ILE P 186
 None
 0.88A 5ih0A-3fg2P:
undetectable		 5ih0A-3fg2P:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhl PUTATIVE
OXIDOREDUCTASE

(Bacteroides
fragilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 TYR A 309
HIS A  19
ILE A  34
TYR A  46
 None
 0.93A 5ih0A-3fhlA:
undetectable		 5ih0A-3fhlA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtu GLUTATHIONE
S-TRANSFERASE

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 ASP B 165
HIS B  18
ILE B  20
TYR B  10
 None
 1.30A 5ih0A-3gtuB:
undetectable		 5ih0A-3gtuB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzb PUTATIVE SNOAL-LIKE
POLYKETIDE CYCLASE

(Shewanella
putrefaciens) 		PF12680
(SnoaL_2) 		4 TYR A  28
ASP A 139
HIS A 137
ILE A  49
 None
MRD  A 154 (-4.6A)
None
None
 1.27A 5ih0A-3gzbA:
undetectable		 5ih0A-3gzbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hh8 METAL ABC
TRANSPORTER
SUBSTRATE-BINDING
LIPOPROTEIN

(Streptococcus
pyogenes) 		PF01297
(ZnuA) 		4 ASP A 280
ILE A  42
TYR A 150
TYR A 210
 FE  A 401 (-2.1A)
None
None
None
 1.27A 5ih0A-3hh8A:
undetectable		 5ih0A-3hh8A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hnp OXIDOREDUCTASE

(Bacillus cereus) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 TYR A 305
HIS A  18
ILE A  33
TYR A  46
 None
 1.13A 5ih0A-3hnpA:
undetectable		 5ih0A-3hnpA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hol TBPB

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 TYR A 215
ASP A 273
ILE A  65
TYR A 243
 None
 1.19A 5ih0A-3holA:
undetectable		 5ih0A-3holA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ASP A  83
ILE A  72
TYR A  68
TYR A  60
 None
None
None
EPE  A   1 (-4.6A)
 1.29A 5ih0A-3i4gA:
undetectable		 5ih0A-3i4gA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE

(Burkholderia
pseudomallei) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 TYR A 355
ASP A 349
ILE A 344
TYR A  38
 None
 1.30A 5ih0A-3imlA:
undetectable		 5ih0A-3imlA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1

(Cypovirus 1) 		no annotation 4 ASP B1167
HIS B1169
ILE B1171
TYR B1173
 None
 1.28A 5ih0A-3iz3B:
undetectable		 5ih0A-3iz3B:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN

(Klebsiella
pneumoniae) 		PF00149
(Metallophos) 		4 ASP A  61
HIS A  18
ILE A  63
TYR A 106
 MN  A 342 (-2.9A)
MN  A 340 (-3.5A)
None
None
 1.22A 5ih0A-3jyfA:
undetectable		 5ih0A-3jyfA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb6 D-LACTATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 TYR A  51
ASP A 255
HIS A 294
TYR A  96
 PPI  A 453 ( 4.7A)
NAD  A 400 (-4.1A)
LAC  A 399 (-3.9A)
LAC  A 399 ( 4.6A)
 1.09A 5ih0A-3kb6A:
undetectable		 5ih0A-3kb6A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus scrofa;
Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase)
PF00287
(Na_K-ATPase) 		4 TYR A1016
ILE A 991
TYR A 994
TYR B  39
 None
 1.24A 5ih0A-3n23A:
1.1		 5ih0A-3n23A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rp2 RAT MAST CELL
PROTEASE II

(Rattus rattus) 		PF00089
(Trypsin) 		4 TYR A 234
HIS A 101
ILE A  90
TYR A 215
 None
 1.01A 5ih0A-3rp2A:
undetectable		 5ih0A-3rp2A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2j DIPEPTIDASE

(Streptomyces
coelicolor) 		PF01244
(Peptidase_M19) 		4 TYR A 145
ASP A 320
HIS A  20
ILE A 317
 None
L3A  A 401 (-3.1A)
ZN  A 402 ( 3.3A)
None
 1.00A 5ih0A-3s2jA:
undetectable		 5ih0A-3s2jA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 TYR A 201
ASP A 140
HIS A 138
ILE A 187
 None
 1.20A 5ih0A-3sunA:
undetectable		 5ih0A-3sunA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrd FLAVOCYTOCHROME C
FLAVIN SUBUNIT

(Thermochromatium
tepidum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		4 TYR B 208
ASP B  52
HIS B 174
ILE B  49
 None
 1.10A 5ih0A-3vrdB:
undetectable		 5ih0A-3vrdB:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1g DNA LIGASE 4

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 ASP A 423
HIS A 482
ILE A 581
TYR A 570
 None
 1.01A 5ih0A-3w1gA:
undetectable		 5ih0A-3w1gA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1o DNA MIMIC PROTEIN
DMP12

(Neisseria
meningitidis) 		PF16779
(DMP12) 		4 TYR A  28
ASP A  71
HIS A 117
ILE A   8
 None
 1.18A 5ih0A-3w1oA:
undetectable		 5ih0A-3w1oA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9v PHOSPHATE-BINDING
PROTEIN

(unidentified
prokaryotic
organism) 		PF12849
(PBP_like_2) 		4 TYR A 307
HIS A  56
ILE A 302
TYR A  72
 None
 1.22A 5ih0A-3w9vA:
undetectable		 5ih0A-3w9vA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6q HISTONE DEACETYLASE
COMPLEX SUBUNIT
SAP18

(Mus musculus) 		PF06487
(SAP18) 		4 ASP A 134
HIS A  41
ILE A 137
TYR A  77
 None
None
None
IPA  A1144 (-3.8A)
 1.25A 5ih0A-4a6qA:
undetectable		 5ih0A-4a6qA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION

(Staphylothermus
marinus) 		PF00128
(Alpha-amylase) 		4 ASP A 272
HIS A 270
TYR A 229
TYR A 598
 None
 1.28A 5ih0A-4aeeA:
3.0		 5ih0A-4aeeA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A

(Aspergillus
nidulans) 		PF07745
(Glyco_hydro_53) 		4 ASP A  79
HIS A  81
ILE A 137
TYR A 215
 None
GOL  A1343 ( 4.6A)
None
ACT  A1336 (-4.0A)
 1.03A 5ih0A-4bf7A:
undetectable		 5ih0A-4bf7A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 TYR A 573
ASP A 630
HIS A 677
ILE A 603
 None
 1.16A 5ih0A-4d8mA:
undetectable		 5ih0A-4d8mA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dav SUGAR FERMENTATION
STIMULATION PROTEIN
HOMOLOG

(Pyrococcus
furiosus) 		PF03749
(SfsA) 		4 ASP A 117
HIS A 155
ILE A 171
TYR A 144
 None
 1.17A 5ih0A-4davA:
undetectable		 5ih0A-4davA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ee8 PRENYLTRANSFERASE

(Streptomyces
cinnamonensis) 		PF11468
(PTase_Orf2) 		4 TYR A 281
ASP A  60
ILE A 284
TYR A 174
 SO4  A 402 (-4.5A)
None
None
SO4  A 401 (-4.6A)
 1.25A 5ih0A-4ee8A:
undetectable		 5ih0A-4ee8A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fb5 PROBABLE
OXIDOREDUCTASE
PROTEIN

(Rhizobium etli) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 TYR A 182
HIS A 356
ILE A 370
TYR A 130
 None
 1.09A 5ih0A-4fb5A:
undetectable		 5ih0A-4fb5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzn BACTERIOCIN

(Pseudomonas
syringae group
genomosp. 3) 		PF14859
(Colicin_M) 		4 TYR A 120
ASP A  87
ILE A 103
TYR A   9
 None
 1.26A 5ih0A-4fznA:
undetectable		 5ih0A-4fznA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk8 HISTIDINOL-PHOSPHATA
SE

(Lactococcus
lactis) 		PF02811
(PHP) 		4 ASP A  17
HIS A  11
ILE A 231
TYR A 161
 ZN  A 302 ( 2.2A)
ZN  A 303 ( 3.3A)
None
None
 0.99A 5ih0A-4gk8A:
undetectable		 5ih0A-4gk8A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk8 HISTIDINOL-PHOSPHATA
SE

(Lactococcus
lactis) 		PF02811
(PHP) 		4 ASP A 228
HIS A   9
ILE A 194
TYR A 135
 ZN  A 303 ( 2.6A)
ZN  A 303 (-3.3A)
None
None
 1.12A 5ih0A-4gk8A:
undetectable		 5ih0A-4gk8A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 ASP A  63
ILE A  57
TYR A  18
TYR A 389
 None
 1.19A 5ih0A-4jclA:
2.4		 5ih0A-4jclA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqt PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF06439
(DUF1080) 		4 ASP A 344
HIS A 434
ILE A 336
TYR A 415
 None
 1.21A 5ih0A-4jqtA:
undetectable		 5ih0A-4jqtA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		4 ASP A 240
HIS A 218
ILE A 222
TYR A 289
 None
 1.17A 5ih0A-4kngA:
undetectable		 5ih0A-4kngA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpr THIOREDOXIN
REDUCTASE 1,
CYTOPLASMIC

(Rattus
norvegicus) 		no annotation 4 TYR E  11
HIS E 138
ILE E 140
TYR E 330
 None
 1.22A 5ih0A-4kprE:
undetectable		 5ih0A-4kprE:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kzy 40S RIBOSOMAL
PROTEIN S2

(Oryctolagus
cuniculus) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		4 TYR C  67
ASP C 117
HIS C 121
ILE C 115
 None
 1.10A 5ih0A-4kzyC:
undetectable		 5ih0A-4kzyC:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Xenopus
tropicalis) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 ASP A 234
HIS A 212
ILE A 216
TYR A 283
 None
 1.21A 5ih0A-4li2A:
undetectable		 5ih0A-4li2A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo2 UDP-GALACTOPYRANOSE
MUTASE

(Campylobacter
jejuni) 		no annotation 4 TYR B 345
ILE B  57
TYR B 180
TYR B 150
 FDA  B 402 (-4.6A)
FDA  B 402 (-4.2A)
None
None
 0.98A 5ih0A-4mo2B:
undetectable		 5ih0A-4mo2B:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL

(Homo sapiens) 		PF01416
(PseudoU_synth_1) 		4 ASP A 146
HIS A 292
ILE A 294
TYR A 203
 None
 1.19A 5ih0A-4nz6A:
undetectable		 5ih0A-4nz6A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o3x TRANSFERRIN BINDING
PROTEIN B

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17484
(TbpB_A) 		4 TYR B 215
ASP B 273
ILE B  65
TYR B 243
 None
 1.13A 5ih0A-4o3xB:
undetectable		 5ih0A-4o3xB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4x TBPB

(Glaesserella
parasuis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 TYR A 220
ASP A 278
ILE A  65
TYR A 248
 None
 1.15A 5ih0A-4o4xA:
undetectable		 5ih0A-4o4xA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oz5 BACILLUS SUBTILIS
HMOB

(Bacillus
subtilis) 		PF03992
(ABM) 		4 HIS A  50
ILE A  37
TYR A 162
TYR A 158
 None
 1.12A 5ih0A-4oz5A:
undetectable		 5ih0A-4oz5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE

(Chlamydia
trachomatis) 		PF00595
(PDZ)
PF03572
(Peptidase_S41) 		4 ASP A  58
HIS A 226
ILE A 224
TYR A 197
 None
 1.10A 5ih0A-4ql6A:
undetectable		 5ih0A-4ql6A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		4 TYR A 101
ASP A  98
HIS A  99
ILE A  57
 None
 1.17A 5ih0A-4qnyA:
5.0		 5ih0A-4qnyA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru5 TAILSPIKE GP27

(Pseudomonas
phage phi297) 		no annotation 4 TYR A 304
ASP A 473
HIS A 475
ILE A 481
 None
 1.27A 5ih0A-4ru5A:
undetectable		 5ih0A-4ru5A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whb PHENYLUREA HYDROLASE
B

(Mycolicibacterium
brisbanense) 		no annotation 4 ASP E 344
HIS E  67
ILE E 368
TYR E 401
 None
 1.06A 5ih0A-4whbE:
undetectable		 5ih0A-4whbE:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT
NA+,K+-ATPASE BETA
SUBUNIT

(Squalus
acanthias;
Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase)
PF00287
(Na_K-ATPase) 		4 TYR A1023
ILE A 998
TYR A1001
TYR B  40
 None
None
None
CLR  B3001 ( 4.0A)
 1.04A 5ih0A-5aw4A:
undetectable		 5ih0A-5aw4A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron) 		PF15979
(Glyco_hydro_115) 		4 ASP A 169
HIS A 216
ILE A 167
TYR A 344
 None
 1.12A 5ih0A-5by3A:
undetectable		 5ih0A-5by3A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c70 GLUCURONIDASE

(Aspergillus
oryzae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 HIS A 398
ILE A 186
TYR A 267
TYR A 176
 None
 1.21A 5ih0A-5c70A:
undetectable		 5ih0A-5c70A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doi TELOMERASE-ASSOCIATE
D PROTEIN 19

(Tetrahymena
thermophila) 		no annotation 4 ASP A   9
HIS A 142
ILE A 129
TYR A 130
 None
 1.18A 5ih0A-5doiA:
undetectable		 5ih0A-5doiA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5a GLUTATHIONE
S-TRANSFERASE U25

(Arabidopsis
thaliana) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 TYR A  73
ASP A   3
HIS A  59
ILE A   6
 None
 1.29A 5ih0A-5g5aA:
undetectable		 5ih0A-5g5aA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		4 TYR A  29
HIS A  61
ILE A 162
TYR A 165
 None
 1.30A 5ih0A-5gslA:
undetectable		 5ih0A-5gslA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdf HYDROLASE

(Streptomyces
flocculus) 		no annotation 4 TYR B 104
ASP B 308
HIS B 349
TYR B 360
 None
 1.05A 5ih0A-5hdfB:
undetectable		 5ih0A-5hdfB:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx0 DIPEPTIDASE

(Aspergillus
fumigatus) 		PF01244
(Peptidase_M19) 		4 TYR A 156
ASP A 294
HIS A  23
ILE A 291
 None
FE  A 402 (-3.9A)
FE  A 401 (-3.7A)
None
 1.15A 5ih0A-5lx0A:
undetectable		 5ih0A-5lx0A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mux 2-METHYLCITRATE
DEHYDRATASE

(Bacillus
subtilis) 		no annotation 4 ASP A  92
HIS A 104
ILE A  88
TYR A 203
 TLA  A 501 ( 4.9A)
TLA  A 501 (-4.0A)
None
None
 1.21A 5ih0A-5muxA:
undetectable		 5ih0A-5muxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndz LYSOZYME,PROTEINASE-
ACTIVATED RECEPTOR
2,SOLUBLE CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
PF07361
(Cytochrom_B562) 		4 TYR A 156
ASP A 228
HIS A 227
TYR A  82
 None
 1.12A 5ih0A-5ndzA:
undetectable		 5ih0A-5ndzA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nj6 PROTEINASE-ACTIVATED
RECEPTOR 2,SOLUBLE
CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		4 TYR A 156
ASP A 228
HIS A 227
TYR A  82
 None
 1.16A 5ih0A-5nj6A:
undetectable		 5ih0A-5nj6A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3

(Saccharomyces
cerevisiae) 		PF08238
(Sel1) 		4 TYR A 551
ILE A 217
TYR A 214
TYR A 507
 None
 1.00A 5ih0A-5v7vA:
undetectable		 5ih0A-5v7vA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvm CADHERIN-23

(Homo sapiens) 		no annotation 4 TYR A2186
ASP A2179
HIS A2178
ILE A2176
 None
 0.85A 5ih0A-5vvmA:
undetectable		 5ih0A-5vvmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzr ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bifidobacterium
bifidum) 		PF11308
(Glyco_hydro_129) 		4 ASP A 322
HIS A 366
TYR A 318
TYR A 550
 CA  A 703 (-2.1A)
CA  A 703 ( 3.3A)
None
None
 1.13A 5ih0A-5wzrA:
2.3		 5ih0A-5wzrA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xm3 GLUCOSE
DEHYDROGENASE

(Methylophaga
aminisulfidivorans) 		no annotation 4 TYR A 617
ASP A 110
ILE A 117
TYR A 554
 None
 1.11A 5ih0A-5xm3A:
undetectable		 5ih0A-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3y DENN
DOMAIN-CONTAINING
PROTEIN 3

(Mus musculus) 		no annotation 4 ASP A 756
HIS A 752
ILE A 750
TYR A 940
 None
 1.04A 5ih0A-6b3yA:
undetectable		 5ih0A-6b3yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)

(Homo sapiens) 		no annotation 4 ASP A1602
HIS A1597
ILE A1599
TYR A1628
 None
 1.21A 5ih0A-6bq1A:
6.2		 5ih0A-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eon BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 ASP A 427
HIS A 426
ILE A 422
TYR A 407
 None
 1.26A 5ih0A-6eonA:
undetectable		 5ih0A-6eonA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-) 		no annotation 4 TYR A 248
ASP A 161
ILE A 235
TYR A 505
 None
ACR  A 602 (-3.4A)
None
None
 1.30A 5ih0A-6gneA:
undetectable		 5ih0A-6gneA:
undetectable