SIMILAR PATTERNS OF AMINO ACIDS FOR 5IH0_A_ERYA404_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 248
GLY A 174
GLU A 280
ALA A 263
ILE A 227
 None
 0.96A 5ih0A-1bxzA:
0.0		 5ih0A-1bxzA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3n AGGLUTININ

(Helianthus
tuberosus) 		PF01419
(Jacalin) 		5 ILE A  71
GLY A 108
ALA A  68
ILE A 141
PHE A 130
 None
 1.13A 5ih0A-1c3nA:
undetectable		 5ih0A-1c3nA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee6 PECTATE LYASE

(Bacillus sp.
KSM-P15) 		PF03211
(Pectate_lyase) 		5 ILE A  57
GLY A  64
PHE A  17
SER A  97
ILE A  96
 None
 1.05A 5ih0A-1ee6A:
0.0		 5ih0A-1ee6A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1em8 DNA POLYMERASE III
CHI SUBUNIT
DNA POLYMERASE III
PSI SUBUNIT

(Escherichia
coli;
Escherichia
coli) 		PF04364
(DNA_pol3_chi)
PF03603
(DNA_III_psi) 		5 GLY A  77
GLU A  54
PHE A  64
ALA B  60
ILE A  41
 None
 1.13A 5ih0A-1em8A:
0.0		 5ih0A-1em8A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE

(Sus scrofa) 		PF00342
(PGI) 		5 GLY A 188
PHE A 205
ALA A 224
SER A 159
ILE A 156
 None
None
None
PA5  A 600 (-3.4A)
None
 1.24A 5ih0A-1gzvA:
0.0		 5ih0A-1gzvA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idj PECTIN LYASE A

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		5 ILE A 337
HIS A 247
GLY A   9
ASN A 336
PHE A 328
 None
 1.21A 5ih0A-1idjA:
0.0		 5ih0A-1idjA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE

(Methylobacterium
extorquens) 		PF09176
(Mpt_N) 		5 ILE A 252
GLY A 248
GLU A 143
ALA A 196
ILE A 217
 None
None
None
NAP  A 456 (-4.7A)
None
 1.07A 5ih0A-1luaA:
undetectable		 5ih0A-1luaA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 ILE A1452
GLY A1457
GLU A1434
ALA A1494
ILE A1465
 None
 1.20A 5ih0A-1ofeA:
0.0		 5ih0A-1ofeA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ph5 TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT

(Sterkiella nova) 		PF02765
(POT1) 		5 ILE A 296
ASN A 295
PHE A 299
ALA A 116
ILE A 160
 None
 1.19A 5ih0A-1ph5A:
undetectable		 5ih0A-1ph5A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkx CDP-GLUCOSE-4,6-DEHY
DRATASE

(Yersinia
pseudotuberculosis) 		PF16363
(GDP_Man_Dehyd) 		5 ASN A 129
ALA A  89
SER A  75
ILE A  76
PHE A  79
 None
NAD  A 360 (-3.3A)
None
None
None
 1.11A 5ih0A-1rkxA:
undetectable		 5ih0A-1rkxA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 ILE A 723
GLY A 720
ASN A 725
PHE A 304
SER A 312
 None
 1.05A 5ih0A-1rrhA:
undetectable		 5ih0A-1rrhA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t2t INTRON-ASSOCIATED
ENDONUCLEASE 1

(Escherichia
virus T4) 		PF07460
(NUMOD3) 		5 ILE A 224
GLY A 227
SER A 206
ILE A 205
PHE A 212
 None
 1.07A 5ih0A-1t2tA:
undetectable		 5ih0A-1t2tA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w18 LEVANSUCRASE

(Gluconacetobacter
diazotrophicus) 		PF02435
(Glyco_hydro_68) 		5 GLY A 453
ASN A 449
GLU A 495
ALA A 523
SER A 483
 None
 1.13A 5ih0A-1w18A:
0.6		 5ih0A-1w18A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9s DNA POLYMERASE

(Escherichia
virus T7) 		PF00476
(DNA_pol_A) 		5 ILE A 562
GLU A 480
PHE A 524
ALA A 513
ILE A 500
 None
 1.13A 5ih0A-1x9sA:
undetectable		 5ih0A-1x9sA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Sulfolobus
solfataricus) 		PF14681
(UPRTase) 		5 GLY A 211
ARG A 105
ALA A 103
SER A 172
ILE A 203
 None
U5P  A1250 (-3.5A)
None
None
U5P  A1250 (-4.1A)
 1.19A 5ih0A-1xttA:
undetectable		 5ih0A-1xttA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybf AMP NUCLEOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01048
(PNP_UDP_1) 		5 GLY A 156
GLU A 167
ALA A 189
SER A 209
ILE A 208
 None
 1.07A 5ih0A-1ybfA:
undetectable		 5ih0A-1ybfA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE

(Phanerochaete
chrysosporium) 		no annotation 5 ILE A  74
HIS A  20
ASN A 250
PHE A  87
ALA A 102
 None
 1.04A 5ih0A-2cl2A:
0.6		 5ih0A-2cl2A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cun PHOSPHOGLYCERATE
KINASE

(Pyrococcus
horikoshii) 		PF00162
(PGK) 		5 HIS A  72
ALA A 148
SER A 116
ILE A  90
PHE A 115
 None
None
None
MPD  A 509 (-3.9A)
None
 1.25A 5ih0A-2cunA:
undetectable		 5ih0A-2cunA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE

(Mus musculus) 		PF00342
(PGI) 		5 GLY A 189
PHE A 206
ALA A 225
SER A 160
ILE A 157
 None
None
None
PO4  A1601 (-2.7A)
None
 1.21A 5ih0A-2cxnA:
undetectable		 5ih0A-2cxnA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Synechococcus
sp.) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ILE A 223
ASN A 138
ALA A 153
ILE A 276
MET A 272
 None
 1.03A 5ih0A-2d2iA:
undetectable		 5ih0A-2d2iA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exr CYTOKININ
DEHYDROGENASE 7

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		5 GLY A 276
ALA A 181
SER A 388
ILE A 392
PHE A 395
 None
 1.25A 5ih0A-2exrA:
undetectable		 5ih0A-2exrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g02 NISIN BIOSYNTHESIS
PROTEIN NISC

(Lactococcus
lactis) 		PF05147
(LANC_like) 		5 ILE A 339
GLY A 287
ALA A 211
SER A 326
ILE A 324
 None
 1.11A 5ih0A-2g02A:
undetectable		 5ih0A-2g02A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7g RHA04620, PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF02909
(TetR_C) 		5 ILE A 132
GLU A  72
PHE A  80
ALA A 139
SER A 113
 None
 1.25A 5ih0A-2g7gA:
undetectable		 5ih0A-2g7gA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 20
RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 18

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF08612
(Med20)
PF09637
(Med18) 		5 GLY B 206
ASN B 205
SER B 165
ILE B 190
MET A  78
 None
 1.23A 5ih0A-2hzsB:
undetectable		 5ih0A-2hzsB:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 ILE A 230
GLU A 264
ARG A 291
ALA A 328
ILE A 259
 None
 1.21A 5ih0A-2jjdA:
1.9		 5ih0A-2jjdA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx8 TRNA-SPECIFIC
ADENOSINE DEAMINASE

(Streptococcus
pyogenes) 		PF14437
(MafB19-deam) 		5 HIS A  77
GLY A  79
ASN A  80
GLU A  26
ALA A 105
 None
 1.20A 5ih0A-2nx8A:
undetectable		 5ih0A-2nx8A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okj GLUTAMATE
DECARBOXYLASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 GLY A 244
ALA A 396
SER A 249
ILE A 247
PHE A 248
 None
 1.22A 5ih0A-2okjA:
undetectable		 5ih0A-2okjA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okk GLUTAMATE
DECARBOXYLASE 2

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 GLY A 235
ALA A 387
SER A 240
ILE A 238
PHE A 239
 None
 0.98A 5ih0A-2okkA:
undetectable		 5ih0A-2okkA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qiw PEP PHOSPHONOMUTASE

(Corynebacterium
glutamicum) 		PF13714
(PEP_mutase) 		5 ILE A 173
GLY A 150
GLU A 196
ALA A 154
ILE A 208
 None
 1.25A 5ih0A-2qiwA:
undetectable		 5ih0A-2qiwA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7e COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		5 ILE B1763
GLY B1853
ALA B1834
SER B1791
ILE B1790
 None
 1.21A 5ih0A-2r7eB:
undetectable		 5ih0A-2r7eB:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 ILE A 299
GLY A 388
GLU A 227
ILE A  56
MET A 216
 None
 1.25A 5ih0A-2wyaA:
undetectable		 5ih0A-2wyaA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrc HUMAN COMPLEMENT
FACTOR I

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00089
(Trypsin)
PF00530
(SRCR) 		5 ILE A 339
GLY A 348
PHE A 399
ALA A 361
ILE A 352
 None
 1.04A 5ih0A-2xrcA:
undetectable		 5ih0A-2xrcA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06460
(NSP13) 		5 ILE A 157
GLY A 208
PHE A  70
SER A 175
ILE A 171
 None
 1.08A 5ih0A-2xyqA:
undetectable		 5ih0A-2xyqA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzm D-ALANINE--D-ALANINE
LIGASE

(Thermus
thermophilus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 ILE A 286
HIS A  82
GLY A  86
GLU A 199
ALA A 109
 None
DAL  A 401 (-4.5A)
None
None
None
 1.21A 5ih0A-2yzmA:
undetectable		 5ih0A-2yzmA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE

(Mesorhizobium
japonicum) 		PF01494
(FAD_binding_3) 		5 ILE A 103
GLY A  52
GLU A  83
ALA A 298
ILE A 212
 None
None
None
GOL  A 384 (-3.8A)
None
 1.06A 5ih0A-3allA:
0.0		 5ih0A-3allA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b20 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(NADP+)

(Synechococcus
elongatus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ILE A 223
ASN A 138
ALA A 153
ILE A 276
MET A 272
 None
 1.24A 5ih0A-3b20A:
undetectable		 5ih0A-3b20A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e57 UNCHARACTERIZED
PROTEIN TM1382

(Thermotoga
maritima) 		PF00293
(NUDIX) 		5 ILE A 132
GLY A  23
ASN A 133
GLU A 127
PHE A  32
 None
 1.25A 5ih0A-3e57A:
undetectable		 5ih0A-3e57A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e77 PHOSPHOSERINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		5 ILE A 307
GLY A 340
PHE A 360
ALA A 324
ILE A 303
 None
 1.19A 5ih0A-3e77A:
undetectable		 5ih0A-3e77A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 248
GLY A 174
GLU A 280
ALA A 263
ILE A 227
 None
None
PGE  A 357 (-4.5A)
None
None
 1.18A 5ih0A-3fplA:
undetectable		 5ih0A-3fplA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN

(Pseudomonas
protegens) 		PF05193
(Peptidase_M16_C) 		5 ASN A  60
ALA A  44
SER A 175
ILE A 176
MET A 136
 None
 1.17A 5ih0A-3gwbA:
undetectable		 5ih0A-3gwbA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hp0 PUTATIVE POLYKETIDE
BIOSYNTHESIS
ENOYL-COA HYDRATASE
HOMOLOG PKSH

(Bacillus
subtilis) 		PF00378
(ECH_1) 		5 GLY A 156
SER A 171
ILE A 170
PHE A 133
MET A 163
 None
 1.04A 5ih0A-3hp0A:
undetectable		 5ih0A-3hp0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL

(Plasmodium
falciparum) 		PF01180
(DHO_dh) 		5 GLY A 521
PHE A 221
ALA A 514
ILE A 455
PHE A 427
 None
 1.19A 5ih0A-3i6rA:
undetectable		 5ih0A-3i6rA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe) 		PF08389
(Xpo1) 		5 ILE T 715
GLY T 717
GLU T 662
SER T 605
ILE T 606
 None
 1.02A 5ih0A-3icqT:
undetectable		 5ih0A-3icqT:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3id9 MUTT/NUDIX FAMILY
PROTEIN

(Bacillus
thuringiensis) 		PF00293
(NUDIX) 		5 ILE A  29
GLY A 146
SER A 131
ILE A 140
PHE A 135
 None
 1.12A 5ih0A-3id9A:
undetectable		 5ih0A-3id9A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8k ALPHA-AMYLASE, SUSG

(Bacteroides
thetaiotaomicron) 		PF00128
(Alpha-amylase) 		5 HIS A 342
ASN A 354
GLU A 397
PHE A 405
ALA A 361
 None
 1.25A 5ih0A-3k8kA:
undetectable		 5ih0A-3k8kA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnb N-ACETYLTRANSFERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00797
(Acetyltransf_2) 		5 ILE A 110
HIS A 108
GLY A  92
PHE A 137
ILE A 187
 None
COA  A1001 ( 4.1A)
None
None
None
 1.18A 5ih0A-3lnbA:
undetectable		 5ih0A-3lnbA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lss SERYL-TRNA
SYNTHETASE

(Trypanosoma
brucei) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		5 ILE A 462
GLY A 200
GLU A 438
ALA A 208
ILE A 308
 None
 1.12A 5ih0A-3lssA:
undetectable		 5ih0A-3lssA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my9 MUCONATE
CYCLOISOMERASE

(Azorhizobium
caulinodans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 209
HIS A 173
GLY A 169
PHE A 236
PHE A 216
 None
 1.20A 5ih0A-3my9A:
undetectable		 5ih0A-3my9A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbu GLUCOSE-6-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00342
(PGI) 		5 GLY A 186
PHE A 203
ALA A 222
SER A 158
ILE A 155
 None
 1.15A 5ih0A-3nbuA:
undetectable		 5ih0A-3nbuA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5m ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 GLY A 145
SER A 160
ILE A 159
PHE A 121
MET A 152
 None
 1.02A 5ih0A-3p5mA:
undetectable		 5ih0A-3p5mA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqd L-LACTATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A 192
ASN A 190
PHE A 155
ARG A 156
ALA A 172
 None
 0.91A 5ih0A-3pqdA:
undetectable		 5ih0A-3pqdA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqd L-LACTATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A 193
ASN A 190
PHE A 155
ARG A 156
ALA A 172
 None
 1.19A 5ih0A-3pqdA:
undetectable		 5ih0A-3pqdA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qac 11S GLOBULIN SEED
STORAGE PROTEIN

(Amaranthus
hypochondriacus) 		PF00190
(Cupin_1) 		5 HIS A 148
GLY A  84
ARG A 286
ALA A 285
ILE A  76
 None
 1.04A 5ih0A-3qacA:
undetectable		 5ih0A-3qacA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sz4 EXONUCLEASE

(Laribacter
hongkongensis) 		PF09588
(YqaJ) 		5 ILE A  94
HIS A  91
GLY A  96
GLU A 179
ALA A 189
 None
 1.00A 5ih0A-3sz4A:
1.4		 5ih0A-3sz4A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v68 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF10869
(DUF2666) 		5 ILE A 123
GLY A 121
ASN A  38
GLU A  22
ALA A 174
 None
 1.17A 5ih0A-3v68A:
undetectable		 5ih0A-3v68A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuo NTNHA

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		5 GLY A 270
PHE A 358
ALA A 354
ILE A 216
PHE A 214
 None
 1.24A 5ih0A-3vuoA:
undetectable		 5ih0A-3vuoA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbm COPPER-CONTAINING
NITRITE REDUCTASE

(Ralstonia
pickettii) 		PF07732
(Cu-oxidase_3)
PF13442
(Cytochrome_CBB3) 		5 GLY A 269
ALA A 136
SER A  70
PHE A  71
MET A 170
 None
 0.97A 5ih0A-3zbmA:
undetectable		 5ih0A-3zbmA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C

(Homo sapiens) 		PF00560
(LRR_1)
PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 GLY A 180
GLU A 194
PHE A 144
SER A 189
ILE A 188
 None
 1.12A 5ih0A-3zyjA:
undetectable		 5ih0A-3zyjA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3

(Neurospora
crassa;
Neurospora
crassa) 		no annotation
no annotation 		5 GLY A  86
GLU B 568
PHE A  62
ARG A  63
ALA A  48
 None
 1.25A 5ih0A-4czxA:
1.3		 5ih0A-4czxA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 155
ASN A 157
ARG A 150
SER A 217
ILE A 216
 None
 1.21A 5ih0A-4iigA:
undetectable		 5ih0A-4iigA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imd N-ACETYLNEURAMINATE
LYASE

(Pasteurella
multocida) 		PF00701
(DHDPS) 		5 ILE A 146
ASN A 145
PHE A 165
ALA A 167
SER A 104
 None
 1.14A 5ih0A-4imdA:
undetectable		 5ih0A-4imdA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3z D-ERYTHRULOSE
4-PHOSPHATE
DEHYDROGENASE

(Brucella
melitensis) 		no annotation 5 ILE A 270
GLU A 262
ALA A 195
ILE A 251
MET A 233
 None
 1.22A 5ih0A-4k3zA:
undetectable		 5ih0A-4k3zA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpo NUCLEOSIDE
N-RIBOHYDROLASE 3

(Zea mays) 		PF01156
(IU_nuc_hydro) 		5 GLY A  10
ASN A  37
ALA A 165
ILE A 236
PHE A 197
 None
CA  A 401 (-3.8A)
None
None
None
 1.20A 5ih0A-4kpoA:
undetectable		 5ih0A-4kpoA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Campylobacter
jejuni) 		PF00478
(IMPDH) 		5 ILE A 274
GLY A 272
ASN A 273
ALA A 333
PHE A 327
 None
None
IMP  A 500 ( 4.1A)
None
None
 1.21A 5ih0A-4mz1A:
undetectable		 5ih0A-4mz1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng4 PHOSPHOGLYCERATE
KINASE

(Coxiella
burnetii) 		PF00162
(PGK) 		5 ILE A 318
GLY A 193
PHE A 358
ALA A 354
ILE A 312
 None
 0.99A 5ih0A-4ng4A:
undetectable		 5ih0A-4ng4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5h PHENYLACETALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 ILE A 364
GLY A 377
GLU A 406
ALA A 372
ILE A 301
 None
 1.14A 5ih0A-4o5hA:
undetectable		 5ih0A-4o5hA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi6 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		5 ILE A 740
ASN A 706
GLU A 758
ALA A 480
ILE A 764
 None
None
None
FAD  A 902 (-3.9A)
None
 1.25A 5ih0A-4qi6A:
1.2		 5ih0A-4qi6A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		5 ILE A 248
HIS A 247
GLY A 216
ARG A 251
MET A 266
 None
 1.05A 5ih0A-4qjyA:
1.0		 5ih0A-4qjyA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyj ALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 ILE A 356
GLY A 369
GLU A 400
ALA A 364
ILE A 293
 None
 0.94A 5ih0A-4qyjA:
undetectable		 5ih0A-4qyjA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0j UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF09704
(Cas_Cas5d) 		5 ILE A 137
GLY A  48
GLU A 143
PHE A  20
ALA A  41
 None
 1.22A 5ih0A-4r0jA:
undetectable		 5ih0A-4r0jA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rep GAMMA-CAROTENE
DESATURASE

(Nonlabens
dokdonensis) 		PF01593
(Amino_oxidase) 		5 GLY A  37
GLU A  64
ALA A  17
ILE A 469
PHE A  57
 None
None
None
FAD  A 501 (-4.2A)
None
 1.25A 5ih0A-4repA:
undetectable		 5ih0A-4repA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgw TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1

(Homo sapiens) 		PF12157
(DUF3591) 		5 ILE A 944
GLU A 916
ARG A 957
ALA A 958
SER A 817
 None
 1.05A 5ih0A-4rgwA:
undetectable		 5ih0A-4rgwA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzu ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 GLY A 192
ASN A 193
ALA A 182
SER A 131
ILE A 130
 None
None
CL  A1487 (-3.8A)
None
None
 1.21A 5ih0A-4uzuA:
undetectable		 5ih0A-4uzuA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjv RIBOSOME ASSEMBLY
PROTEIN 4

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 GLY A 288
GLU A 199
ARG A 250
ALA A 252
SER A 247
 None
 1.19A 5ih0A-4wjvA:
2.1		 5ih0A-4wjvA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8q PUTATIVE RETAINING
B-GLYCOSIDASE

(Saccharophagus
degradans) 		PF00150
(Cellulase) 		5 ILE A 135
PHE A  68
ALA A 182
ILE A  73
PHE A 332
 None
 1.16A 5ih0A-5a8qA:
undetectable		 5ih0A-5a8qA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnn CAPSID PROTEIN VP2

(Enterovirus D) 		PF00073
(Rhv) 		5 ILE B 108
GLU B 150
PHE B  63
SER B  68
ILE B 228
 None
 1.20A 5ih0A-5bnnB:
undetectable		 5ih0A-5bnnB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby SEPARASE

(Chaetomium
thermophilum) 		PF03568
(Peptidase_C50) 		5 ILE A1884
HIS A1830
GLY A1887
GLU A1835
ALA A1935
 None
 1.15A 5ih0A-5fbyA:
undetectable		 5ih0A-5fbyA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1

(Homo sapiens) 		PF12157
(DUF3591) 		5 ILE G 944
GLU G 916
ARG G 957
ALA G 958
SER G 817
 None
 1.05A 5ih0A-5furG:
undetectable		 5ih0A-5furG:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5goo ALKALINE INVERTASE

(Nostoc sp. PCC
7120) 		PF12899
(Glyco_hydro_100) 		5 GLY A 438
ALA A 396
SER A 456
ILE A 455
PHE A 454
 None
 0.97A 5ih0A-5gooA:
undetectable		 5ih0A-5gooA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 HIS A 106
GLY A 190
ASN A 192
ALA A 263
SER A  79
 None
 1.19A 5ih0A-5hc4A:
undetectable		 5ih0A-5hc4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 HIS A 106
GLY A 190
ASN A 192
ALA A 263
SER A 163
 None
 1.05A 5ih0A-5hc4A:
undetectable		 5ih0A-5hc4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hnz PROTEIN CLARET
SEGREGATIONAL,PROTEI
N CLARET
SEGREGATIONAL,PLUS-E
ND DIRECTED
KINESIN-1/KINESIN-14
,PROTEIN CLARET
SEGREGATIONAL,PROTEI
N CLARET
SEGREGATIONAL

(Drosophila
melanogaster;
Rattus
norvegicus) 		PF00225
(Kinesin) 		5 ILE K 270
HIS K 221
ALA K 259
SER K 330
PHE K 334
 None
 1.25A 5ih0A-5hnzK:
0.0		 5ih0A-5hnzK:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hoe HYDROLASE

(Sinorhizobium
meliloti) 		PF13472
(Lipase_GDSL_2) 		5 ILE A 188
GLY A 185
ALA A 145
SER A  13
MET A  92
 None
None
None
PO4  A 301 (-2.5A)
None
 1.20A 5ih0A-5hoeA:
undetectable		 5ih0A-5hoeA:
21.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II

(Escherichia
coli) 		PF01636
(APH) 		5 ARG A 237
ALA A 238
SER A 276
ILE A 277
PHE A 280
 None
 0.76A 5ih0A-5iguA:
31.2		 5ih0A-5iguA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II

(Escherichia
coli) 		PF01636
(APH) 		5 ARG A 237
SER A 276
ILE A 277
PHE A 280
MET A 292
 None
 0.99A 5ih0A-5iguA:
31.2		 5ih0A-5iguA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II

(Escherichia
coli) 		PF01636
(APH) 		5 GLU A 222
PHE A 234
ARG A 237
ALA A 238
SER A 276
 None
 0.50A 5ih0A-5iguA:
31.2		 5ih0A-5iguA:
99.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 155
ASN A 157
ARG A 150
SER A 214
ILE A 213
 None
 1.19A 5ih0A-5ju6A:
undetectable		 5ih0A-5ju6A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng6 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Francisella
tularensis) 		no annotation 5 ILE A1085
HIS A1261
ALA A1138
ILE A1286
MET A1268
 None
 1.19A 5ih0A-5ng6A:
undetectable		 5ih0A-5ng6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nii THIOREDOXIN
REDUCTASE

(Desulfovibrio
vulgaris) 		no annotation 5 ILE A 105
GLY A  10
ALA A  72
ILE A  92
PHE A  90
 None
FAD  A 401 (-3.3A)
None
None
None
 1.08A 5ih0A-5niiA:
undetectable		 5ih0A-5niiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzb D-AMINOPEPTIDASE

(Burkholderia
sp. LK4) 		PF03576
(Peptidase_S58) 		5 ILE A 329
GLY A 179
ASN A 331
ILE A 244
PHE A 281
 None
 1.03A 5ih0A-5tzbA:
undetectable		 5ih0A-5tzbA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzb D-AMINOPEPTIDASE

(Burkholderia
sp. LK4) 		PF03576
(Peptidase_S58) 		5 ILE A 329
GLY A 265
GLU A 173
ARG A 209
ALA A 211
 None
 1.15A 5ih0A-5tzbA:
undetectable		 5ih0A-5tzbA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bde 2,4-DIHYDROXYHEPT-2-
ENE-1,7-DIOIC ACID
ALDOLASE

(Kordia algicida) 		no annotation 5 GLY A 145
ASN A 148
ALA A 158
SER A  98
ILE A  99
 None
None
None
None
HEM  A 201 (-4.5A)
 1.10A 5ih0A-6bdeA:
undetectable		 5ih0A-6bdeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzc GLUCOSE-6-PHOSPHATE
ISOMERASE

(Elizabethkingia
anophelis) 		no annotation 5 GLY A 186
PHE A 203
ALA A 222
SER A 158
ILE A 155
 None
None
None
G6P  A 601 (-2.6A)
None
 1.25A 5ih0A-6bzcA:
undetectable		 5ih0A-6bzcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 ILE H 319
GLY H 287
ASN H 286
GLU H 310
PHE H 282
 None
 1.09A 5ih0A-6chsH:
undetectable		 5ih0A-6chsH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 5 ILE A 382
PHE A 370
ARG A 403
ALA A 404
SER A 398
 None
 1.05A 5ih0A-6czxA:
undetectable		 5ih0A-6czxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 5 GLY A 199
ASN A  59
GLU A  70
ALA A 246
ILE A  65
 None
 1.00A 5ih0A-6ekiA:
undetectable		 5ih0A-6ekiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epe PROTEASOME SUBUNIT
BETA TYPE-1

(Rattus
norvegicus) 		no annotation 5 HIS 6 190
GLY 6 181
SER 6 208
ILE 6 207
PHE 6 206
 None
 1.23A 5ih0A-6epe6:
undetectable		 5ih0A-6epe6:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6erc PEROXINECTIN A

(Dictyostelium
discoideum) 		no annotation 5 ILE A 170
GLY A 172
ASN A 173
ALA A 104
ILE A 243
 None
None
NA  A 609 (-3.3A)
HEM  A 604 ( 3.9A)
None
 1.21A 5ih0A-6ercA:
undetectable		 5ih0A-6ercA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X

(Clostridium
botulinum) 		no annotation 5 ILE A 239
GLY A 178
ASN A 293
GLU A 266
PHE A 244
 None
 1.24A 5ih0A-6f4eA:
undetectable		 5ih0A-6f4eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g1o -

(-) 		no annotation 5 ILE A 445
HIS A 448
GLU A 352
ALA A 375
ILE A 182
 None
 1.00A 5ih0A-6g1oA:
undetectable		 5ih0A-6g1oA:
undetectable