SIMILAR PATTERNS OF AMINO ACIDS FOR 5IH0_A_ERYA404

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 248
GLY A 174
GLU A 280
ALA A 263
ILE A 227
 None
 0.96A 5ih0A-1bxzA:
0.0		 5ih0A-1bxzA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3n AGGLUTININ

(Helianthus
tuberosus) 		PF01419
(Jacalin) 		5 ILE A  71
GLY A 108
ALA A  68
ILE A 141
PHE A 130
 None
 1.13A 5ih0A-1c3nA:
undetectable		 5ih0A-1c3nA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee6 PECTATE LYASE

(Bacillus sp.
KSM-P15) 		PF03211
(Pectate_lyase) 		5 ILE A  57
GLY A  64
PHE A  17
SER A  97
ILE A  96
 None
 1.05A 5ih0A-1ee6A:
0.0		 5ih0A-1ee6A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1em8 DNA POLYMERASE III
CHI SUBUNIT
DNA POLYMERASE III
PSI SUBUNIT

(Escherichia
coli;
Escherichia
coli) 		PF04364
(DNA_pol3_chi)
PF03603
(DNA_III_psi) 		5 GLY A  77
GLU A  54
PHE A  64
ALA B  60
ILE A  41
 None
 1.13A 5ih0A-1em8A:
0.0		 5ih0A-1em8A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE

(Sus scrofa) 		PF00342
(PGI) 		5 GLY A 188
PHE A 205
ALA A 224
SER A 159
ILE A 156
 None
None
None
PA5  A 600 (-3.4A)
None
 1.24A 5ih0A-1gzvA:
0.0		 5ih0A-1gzvA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idj PECTIN LYASE A

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		5 ILE A 337
HIS A 247
GLY A   9
ASN A 336
PHE A 328
 None
 1.21A 5ih0A-1idjA:
0.0		 5ih0A-1idjA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE

(Methylobacterium
extorquens) 		PF09176
(Mpt_N) 		5 ILE A 252
GLY A 248
GLU A 143
ALA A 196
ILE A 217
 None
None
None
NAP  A 456 (-4.7A)
None
 1.07A 5ih0A-1luaA:
undetectable		 5ih0A-1luaA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 ILE A1452
GLY A1457
GLU A1434
ALA A1494
ILE A1465
 None
 1.20A 5ih0A-1ofeA:
0.0		 5ih0A-1ofeA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ph5 TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT

(Sterkiella nova) 		PF02765
(POT1) 		5 ILE A 296
ASN A 295
PHE A 299
ALA A 116
ILE A 160
 None
 1.19A 5ih0A-1ph5A:
undetectable		 5ih0A-1ph5A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkx CDP-GLUCOSE-4,6-DEHY
DRATASE

(Yersinia
pseudotuberculosis) 		PF16363
(GDP_Man_Dehyd) 		5 ASN A 129
ALA A  89
SER A  75
ILE A  76
PHE A  79
 None
NAD  A 360 (-3.3A)
None
None
None
 1.11A 5ih0A-1rkxA:
undetectable		 5ih0A-1rkxA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 ILE A 723
GLY A 720
ASN A 725
PHE A 304
SER A 312
 None
 1.05A 5ih0A-1rrhA:
undetectable		 5ih0A-1rrhA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t2t INTRON-ASSOCIATED
ENDONUCLEASE 1

(Escherichia
virus T4) 		PF07460
(NUMOD3) 		5 ILE A 224
GLY A 227
SER A 206
ILE A 205
PHE A 212
 None
 1.07A 5ih0A-1t2tA:
undetectable		 5ih0A-1t2tA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w18 LEVANSUCRASE

(Gluconacetobacter
diazotrophicus) 		PF02435
(Glyco_hydro_68) 		5 GLY A 453
ASN A 449
GLU A 495
ALA A 523
SER A 483
 None
 1.13A 5ih0A-1w18A:
0.6		 5ih0A-1w18A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9s DNA POLYMERASE

(Escherichia
virus T7) 		PF00476
(DNA_pol_A) 		5 ILE A 562
GLU A 480
PHE A 524
ALA A 513
ILE A 500
 None
 1.13A 5ih0A-1x9sA:
undetectable		 5ih0A-1x9sA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Sulfolobus
solfataricus) 		PF14681
(UPRTase) 		5 GLY A 211
ARG A 105
ALA A 103
SER A 172
ILE A 203
 None
U5P  A1250 (-3.5A)
None
None
U5P  A1250 (-4.1A)
 1.19A 5ih0A-1xttA:
undetectable		 5ih0A-1xttA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybf AMP NUCLEOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01048
(PNP_UDP_1) 		5 GLY A 156
GLU A 167
ALA A 189
SER A 209
ILE A 208
 None
 1.07A 5ih0A-1ybfA:
undetectable		 5ih0A-1ybfA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE

(Phanerochaete
chrysosporium) 		no annotation 5 ILE A  74
HIS A  20
ASN A 250
PHE A  87
ALA A 102
 None
 1.04A 5ih0A-2cl2A:
0.6		 5ih0A-2cl2A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cun PHOSPHOGLYCERATE
KINASE

(Pyrococcus
horikoshii) 		PF00162
(PGK) 		5 HIS A  72
ALA A 148
SER A 116
ILE A  90
PHE A 115
 None
None
None
MPD  A 509 (-3.9A)
None
 1.25A 5ih0A-2cunA:
undetectable		 5ih0A-2cunA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE

(Mus musculus) 		PF00342
(PGI) 		5 GLY A 189
PHE A 206
ALA A 225
SER A 160
ILE A 157
 None
None
None
PO4  A1601 (-2.7A)
None
 1.21A 5ih0A-2cxnA:
undetectable		 5ih0A-2cxnA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Synechococcus
sp.) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ILE A 223
ASN A 138
ALA A 153
ILE A 276
MET A 272
 None
 1.03A 5ih0A-2d2iA:
undetectable		 5ih0A-2d2iA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exr CYTOKININ
DEHYDROGENASE 7

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		5 GLY A 276
ALA A 181
SER A 388
ILE A 392
PHE A 395
 None
 1.25A 5ih0A-2exrA:
undetectable		 5ih0A-2exrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g02 NISIN BIOSYNTHESIS
PROTEIN NISC

(Lactococcus
lactis) 		PF05147
(LANC_like) 		5 ILE A 339
GLY A 287
ALA A 211
SER A 326
ILE A 324
 None
 1.11A 5ih0A-2g02A:
undetectable		 5ih0A-2g02A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7g RHA04620, PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF02909
(TetR_C) 		5 ILE A 132
GLU A  72
PHE A  80
ALA A 139
SER A 113
 None
 1.25A 5ih0A-2g7gA:
undetectable		 5ih0A-2g7gA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 20
RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 18

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF08612
(Med20)
PF09637
(Med18) 		5 GLY B 206
ASN B 205
SER B 165
ILE B 190
MET A  78
 None
 1.23A 5ih0A-2hzsB:
undetectable		 5ih0A-2hzsB:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 ILE A 230
GLU A 264
ARG A 291
ALA A 328
ILE A 259
 None
 1.21A 5ih0A-2jjdA:
1.9		 5ih0A-2jjdA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx8 TRNA-SPECIFIC
ADENOSINE DEAMINASE

(Streptococcus
pyogenes) 		PF14437
(MafB19-deam) 		5 HIS A  77
GLY A  79
ASN A  80
GLU A  26
ALA A 105
 None
 1.20A 5ih0A-2nx8A:
undetectable		 5ih0A-2nx8A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okj GLUTAMATE
DECARBOXYLASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 GLY A 244
ALA A 396
SER A 249
ILE A 247
PHE A 248
 None
 1.22A 5ih0A-2okjA:
undetectable		 5ih0A-2okjA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okk GLUTAMATE
DECARBOXYLASE 2

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 GLY A 235
ALA A 387
SER A 240
ILE A 238
PHE A 239
 None
 0.98A 5ih0A-2okkA:
undetectable		 5ih0A-2okkA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qiw PEP PHOSPHONOMUTASE

(Corynebacterium
glutamicum) 		PF13714
(PEP_mutase) 		5 ILE A 173
GLY A 150
GLU A 196
ALA A 154
ILE A 208
 None
 1.25A 5ih0A-2qiwA:
undetectable		 5ih0A-2qiwA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7e COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		5 ILE B1763
GLY B1853
ALA B1834
SER B1791
ILE B1790
 None
 1.21A 5ih0A-2r7eB:
undetectable		 5ih0A-2r7eB:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 ILE A 299
GLY A 388
GLU A 227
ILE A  56
MET A 216
 None
 1.25A 5ih0A-2wyaA:
undetectable		 5ih0A-2wyaA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrc HUMAN COMPLEMENT
FACTOR I

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00089
(Trypsin)
PF00530
(SRCR) 		5 ILE A 339
GLY A 348
PHE A 399
ALA A 361
ILE A 352
 None
 1.04A 5ih0A-2xrcA:
undetectable		 5ih0A-2xrcA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06460
(NSP13) 		5 ILE A 157
GLY A 208
PHE A  70
SER A 175
ILE A 171
 None
 1.08A 5ih0A-2xyqA:
undetectable		 5ih0A-2xyqA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzm D-ALANINE--D-ALANINE
LIGASE

(Thermus
thermophilus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 ILE A 286
HIS A  82
GLY A  86
GLU A 199
ALA A 109
 None
DAL  A 401 (-4.5A)
None
None
None
 1.21A 5ih0A-2yzmA:
undetectable		 5ih0A-2yzmA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE

(Mesorhizobium
japonicum) 		PF01494
(FAD_binding_3) 		5 ILE A 103
GLY A  52
GLU A  83
ALA A 298
ILE A 212
 None
None
None
GOL  A 384 (-3.8A)
None
 1.06A 5ih0A-3allA:
0.0		 5ih0A-3allA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b20 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(NADP+)

(Synechococcus
elongatus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ILE A 223
ASN A 138
ALA A 153
ILE A 276
MET A 272
 None
 1.24A 5ih0A-3b20A:
undetectable		 5ih0A-3b20A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e57 UNCHARACTERIZED
PROTEIN TM1382

(Thermotoga
maritima) 		PF00293
(NUDIX) 		5 ILE A 132
GLY A  23
ASN A 133
GLU A 127
PHE A  32
 None
 1.25A 5ih0A-3e57A:
undetectable		 5ih0A-3e57A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e77 PHOSPHOSERINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		5 ILE A 307
GLY A 340
PHE A 360
ALA A 324
ILE A 303
 None
 1.19A 5ih0A-3e77A:
undetectable		 5ih0A-3e77A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 248
GLY A 174
GLU A 280
ALA A 263
ILE A 227
 None
None
PGE  A 357 (-4.5A)
None
None
 1.18A 5ih0A-3fplA:
undetectable		 5ih0A-3fplA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN

(Pseudomonas
protegens) 		PF05193
(Peptidase_M16_C) 		5 ASN A  60
ALA A  44
SER A 175
ILE A 176
MET A 136
 None
 1.17A 5ih0A-3gwbA:
undetectable		 5ih0A-3gwbA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hp0 PUTATIVE POLYKETIDE
BIOSYNTHESIS
ENOYL-COA HYDRATASE
HOMOLOG PKSH

(Bacillus
subtilis) 		PF00378
(ECH_1) 		5 GLY A 156
SER A 171
ILE A 170
PHE A 133
MET A 163
 None
 1.04A 5ih0A-3hp0A:
undetectable		 5ih0A-3hp0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL

(Plasmodium
falciparum) 		PF01180
(DHO_dh) 		5 GLY A 521
PHE A 221
ALA A 514
ILE A 455
PHE A 427
 None
 1.19A 5ih0A-3i6rA:
undetectable		 5ih0A-3i6rA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe) 		PF08389
(Xpo1) 		5 ILE T 715
GLY T 717
GLU T 662
SER T 605
ILE T 606
 None
 1.02A 5ih0A-3icqT:
undetectable		 5ih0A-3icqT:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3id9 MUTT/NUDIX FAMILY
PROTEIN

(Bacillus
thuringiensis) 		PF00293
(NUDIX) 		5 ILE A  29
GLY A 146
SER A 131
ILE A 140
PHE A 135
 None
 1.12A 5ih0A-3id9A:
undetectable		 5ih0A-3id9A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8k ALPHA-AMYLASE, SUSG

(Bacteroides
thetaiotaomicron) 		PF00128
(Alpha-amylase) 		5 HIS A 342
ASN A 354
GLU A 397
PHE A 405
ALA A 361
 None
 1.25A 5ih0A-3k8kA:
undetectable		 5ih0A-3k8kA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnb N-ACETYLTRANSFERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00797
(Acetyltransf_2) 		5 ILE A 110
HIS A 108
GLY A  92
PHE A 137
ILE A 187
 None
COA  A1001 ( 4.1A)
None
None
None
 1.18A 5ih0A-3lnbA:
undetectable		 5ih0A-3lnbA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lss SERYL-TRNA
SYNTHETASE

(Trypanosoma
brucei) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		5 ILE A 462
GLY A 200
GLU A 438
ALA A 208
ILE A 308
 None
 1.12A 5ih0A-3lssA:
undetectable		 5ih0A-3lssA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my9 MUCONATE
CYCLOISOMERASE

(Azorhizobium
caulinodans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 209
HIS A 173
GLY A 169
PHE A 236
PHE A 216
 None
 1.20A 5ih0A-3my9A:
undetectable		 5ih0A-3my9A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbu GLUCOSE-6-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00342
(PGI) 		5 GLY A 186
PHE A 203
ALA A 222
SER A 158
ILE A 155
 None
 1.15A 5ih0A-3nbuA:
undetectable		 5ih0A-3nbuA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5m ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 GLY A 145
SER A 160
ILE A 159
PHE A 121
MET A 152
 None
 1.02A 5ih0A-3p5mA:
undetectable		 5ih0A-3p5mA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqd L-LACTATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A 192
ASN A 190
PHE A 155
ARG A 156
ALA A 172
 None
 0.91A 5ih0A-3pqdA:
undetectable		 5ih0A-3pqdA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqd L-LACTATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A 193
ASN A 190
PHE A 155
ARG A 156
ALA A 172
 None
 1.19A 5ih0A-3pqdA:
undetectable		 5ih0A-3pqdA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qac 11S GLOBULIN SEED
STORAGE PROTEIN

(Amaranthus
hypochondriacus) 		PF00190
(Cupin_1) 		5 HIS A 148
GLY A  84
ARG A 286
ALA A 285
ILE A  76
 None
 1.04A 5ih0A-3qacA:
undetectable		 5ih0A-3qacA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sz4 EXONUCLEASE

(Laribacter
hongkongensis) 		PF09588
(YqaJ) 		5 ILE A  94
HIS A  91
GLY A  96
GLU A 179
ALA A 189
 None
 1.00A 5ih0A-3sz4A:
1.4		 5ih0A-3sz4A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v68 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF10869
(DUF2666) 		5 ILE A 123
GLY A 121
ASN A  38
GLU A  22
ALA A 174
 None
 1.17A 5ih0A-3v68A:
undetectable		 5ih0A-3v68A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuo NTNHA

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		5 GLY A 270
PHE A 358
ALA A 354
ILE A 216
PHE A 214
 None
 1.24A 5ih0A-3vuoA:
undetectable		 5ih0A-3vuoA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbm COPPER-CONTAINING
NITRITE REDUCTASE

(Ralstonia
pickettii) 		PF07732
(Cu-oxidase_3)
PF13442
(Cytochrome_CBB3) 		5 GLY A 269
ALA A 136
SER A  70
PHE A  71
MET A 170
 None
 0.97A 5ih0A-3zbmA:
undetectable		 5ih0A-3zbmA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C

(Homo sapiens) 		PF00560
(LRR_1)
PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 GLY A 180
GLU A 194
PHE A 144
SER A 189
ILE A 188
 None
 1.12A 5ih0A-3zyjA:
undetectable		 5ih0A-3zyjA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3

(Neurospora
crassa;
Neurospora
crassa) 		no annotation
no annotation 		5 GLY A  86
GLU B 568
PHE A  62
ARG A  63
ALA A  48
 None
 1.25A 5ih0A-4czxA:
1.3		 5ih0A-4czxA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 155
ASN A 157
ARG A 150
SER A 217
ILE A 216
 None
 1.21A 5ih0A-4iigA:
undetectable		 5ih0A-4iigA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imd N-ACETYLNEURAMINATE
LYASE

(Pasteurella
multocida) 		PF00701
(DHDPS) 		5 ILE A 146
ASN A 145
PHE A 165
ALA A 167
SER A 104
 None
 1.14A 5ih0A-4imdA:
undetectable		 5ih0A-4imdA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3z D-ERYTHRULOSE
4-PHOSPHATE
DEHYDROGENASE

(Brucella
melitensis) 		no annotation 5 ILE A 270
GLU A 262
ALA A 195
ILE A 251
MET A 233
 None
 1.22A 5ih0A-4k3zA:
undetectable		 5ih0A-4k3zA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpo NUCLEOSIDE
N-RIBOHYDROLASE 3

(Zea mays) 		PF01156
(IU_nuc_hydro) 		5 GLY A  10
ASN A  37
ALA A 165
ILE A 236
PHE A 197
 None
CA  A 401 (-3.8A)
None
None
None
 1.20A 5ih0A-4kpoA:
undetectable		 5ih0A-4kpoA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Campylobacter
jejuni) 		PF00478
(IMPDH) 		5 ILE A 274
GLY A 272
ASN A 273
ALA A 333
PHE A 327
 None
None
IMP  A 500 ( 4.1A)
None
None
 1.21A 5ih0A-4mz1A:
undetectable		 5ih0A-4mz1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng4 PHOSPHOGLYCERATE
KINASE

(Coxiella
burnetii) 		PF00162
(PGK) 		5 ILE A 318
GLY A 193
PHE A 358
ALA A 354
ILE A 312
 None
 0.99A 5ih0A-4ng4A:
undetectable		 5ih0A-4ng4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5h PHENYLACETALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 ILE A 364
GLY A 377
GLU A 406
ALA A 372
ILE A 301
 None
 1.14A 5ih0A-4o5hA:
undetectable		 5ih0A-4o5hA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi6 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		5 ILE A 740
ASN A 706
GLU A 758
ALA A 480
ILE A 764
 None
None
None
FAD  A 902 (-3.9A)
None
 1.25A 5ih0A-4qi6A:
1.2		 5ih0A-4qi6A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		5 ILE A 248
HIS A 247
GLY A 216
ARG A 251
MET A 266
 None
 1.05A 5ih0A-4qjyA:
1.0		 5ih0A-4qjyA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyj ALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 ILE A 356
GLY A 369
GLU A 400
ALA A 364
ILE A 293
 None
 0.94A 5ih0A-4qyjA:
undetectable		 5ih0A-4qyjA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0j UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF09704
(Cas_Cas5d) 		5 ILE A 137
GLY A  48
GLU A 143
PHE A  20
ALA A  41
 None
 1.22A 5ih0A-4r0jA:
undetectable		 5ih0A-4r0jA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rep GAMMA-CAROTENE
DESATURASE

(Nonlabens
dokdonensis) 		PF01593
(Amino_oxidase) 		5 GLY A  37
GLU A  64
ALA A  17
ILE A 469
PHE A  57
 None
None
None
FAD  A 501 (-4.2A)
None
 1.25A 5ih0A-4repA:
undetectable		 5ih0A-4repA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgw TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1

(Homo sapiens) 		PF12157
(DUF3591) 		5 ILE A 944
GLU A 916
ARG A 957
ALA A 958
SER A 817
 None
 1.05A 5ih0A-4rgwA:
undetectable		 5ih0A-4rgwA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzu ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 GLY A 192
ASN A 193
ALA A 182
SER A 131
ILE A 130
 None
None
CL  A1487 (-3.8A)
None
None
 1.21A 5ih0A-4uzuA:
undetectable		 5ih0A-4uzuA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjv RIBOSOME ASSEMBLY
PROTEIN 4

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 GLY A 288
GLU A 199
ARG A 250
ALA A 252
SER A 247
 None
 1.19A 5ih0A-4wjvA:
2.1		 5ih0A-4wjvA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8q PUTATIVE RETAINING
B-GLYCOSIDASE

(Saccharophagus
degradans) 		PF00150
(Cellulase) 		5 ILE A 135
PHE A  68
ALA A 182
ILE A  73
PHE A 332
 None
 1.16A 5ih0A-5a8qA:
undetectable		 5ih0A-5a8qA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnn CAPSID PROTEIN VP2

(Enterovirus D) 		PF00073
(Rhv) 		5 ILE B 108
GLU B 150
PHE B  63
SER B  68
ILE B 228
 None
 1.20A 5ih0A-5bnnB:
undetectable		 5ih0A-5bnnB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby SEPARASE

(Chaetomium
thermophilum) 		PF03568
(Peptidase_C50) 		5 ILE A1884
HIS A1830
GLY A1887
GLU A1835
ALA A1935
 None
 1.15A 5ih0A-5fbyA:
undetectable		 5ih0A-5fbyA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1

(Homo sapiens) 		PF12157
(DUF3591) 		5 ILE G 944
GLU G 916
ARG G 957
ALA G 958
SER G 817
 None
 1.05A 5ih0A-5furG:
undetectable		 5ih0A-5furG:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5goo ALKALINE INVERTASE

(Nostoc sp. PCC
7120) 		PF12899
(Glyco_hydro_100) 		5 GLY A 438
ALA A 396
SER A 456
ILE A 455
PHE A 454
 None
 0.97A 5ih0A-5gooA:
undetectable		 5ih0A-5gooA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 HIS A 106
GLY A 190
ASN A 192
ALA A 263
SER A  79
 None
 1.19A 5ih0A-5hc4A:
undetectable		 5ih0A-5hc4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 HIS A 106
GLY A 190
ASN A 192
ALA A 263
SER A 163
 None
 1.05A 5ih0A-5hc4A:
undetectable		 5ih0A-5hc4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hnz PROTEIN CLARET
SEGREGATIONAL,PROTEI
N CLARET
SEGREGATIONAL,PLUS-E
ND DIRECTED
KINESIN-1/KINESIN-14
,PROTEIN CLARET
SEGREGATIONAL,PROTEI
N CLARET
SEGREGATIONAL

(Drosophila
melanogaster;
Rattus
norvegicus) 		PF00225
(Kinesin) 		5 ILE K 270
HIS K 221
ALA K 259
SER K 330
PHE K 334
 None
 1.25A 5ih0A-5hnzK:
0.0		 5ih0A-5hnzK:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hoe HYDROLASE

(Sinorhizobium
meliloti) 		PF13472
(Lipase_GDSL_2) 		5 ILE A 188
GLY A 185
ALA A 145
SER A  13
MET A  92
 None
None
None
PO4  A 301 (-2.5A)
None
 1.20A 5ih0A-5hoeA:
undetectable		 5ih0A-5hoeA:
21.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II

(Escherichia
coli) 		PF01636
(APH) 		5 ARG A 237
ALA A 238
SER A 276
ILE A 277
PHE A 280
 None
 0.76A 5ih0A-5iguA:
31.2		 5ih0A-5iguA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II

(Escherichia
coli) 		PF01636
(APH) 		5 ARG A 237
SER A 276
ILE A 277
PHE A 280
MET A 292
 None
 0.99A 5ih0A-5iguA:
31.2		 5ih0A-5iguA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II

(Escherichia
coli) 		PF01636
(APH) 		5 GLU A 222
PHE A 234
ARG A 237
ALA A 238
SER A 276
 None
 0.50A 5ih0A-5iguA:
31.2		 5ih0A-5iguA:
99.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 155
ASN A 157
ARG A 150
SER A 214
ILE A 213
 None
 1.19A 5ih0A-5ju6A:
undetectable		 5ih0A-5ju6A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng6 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Francisella
tularensis) 		no annotation 5 ILE A1085
HIS A1261
ALA A1138
ILE A1286
MET A1268
 None
 1.19A 5ih0A-5ng6A:
undetectable		 5ih0A-5ng6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nii THIOREDOXIN
REDUCTASE

(Desulfovibrio
vulgaris) 		no annotation 5 ILE A 105
GLY A  10
ALA A  72
ILE A  92
PHE A  90
 None
FAD  A 401 (-3.3A)
None
None
None
 1.08A 5ih0A-5niiA:
undetectable		 5ih0A-5niiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzb D-AMINOPEPTIDASE

(Burkholderia
sp. LK4) 		PF03576
(Peptidase_S58) 		5 ILE A 329
GLY A 179
ASN A 331
ILE A 244
PHE A 281
 None
 1.03A 5ih0A-5tzbA:
undetectable		 5ih0A-5tzbA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzb D-AMINOPEPTIDASE

(Burkholderia
sp. LK4) 		PF03576
(Peptidase_S58) 		5 ILE A 329
GLY A 265
GLU A 173
ARG A 209
ALA A 211
 None
 1.15A 5ih0A-5tzbA:
undetectable		 5ih0A-5tzbA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bde 2,4-DIHYDROXYHEPT-2-
ENE-1,7-DIOIC ACID
ALDOLASE

(Kordia algicida) 		no annotation 5 GLY A 145
ASN A 148
ALA A 158
SER A  98
ILE A  99
 None
None
None
None
HEM  A 201 (-4.5A)
 1.10A 5ih0A-6bdeA:
undetectable		 5ih0A-6bdeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzc GLUCOSE-6-PHOSPHATE
ISOMERASE

(Elizabethkingia
anophelis) 		no annotation 5 GLY A 186
PHE A 203
ALA A 222
SER A 158
ILE A 155
 None
None
None
G6P  A 601 (-2.6A)
None
 1.25A 5ih0A-6bzcA:
undetectable		 5ih0A-6bzcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 ILE H 319
GLY H 287
ASN H 286
GLU H 310
PHE H 282
 None
 1.09A 5ih0A-6chsH:
undetectable		 5ih0A-6chsH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 5 ILE A 382
PHE A 370
ARG A 403
ALA A 404
SER A 398
 None
 1.05A 5ih0A-6czxA:
undetectable		 5ih0A-6czxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 5 GLY A 199
ASN A  59
GLU A  70
ALA A 246
ILE A  65
 None
 1.00A 5ih0A-6ekiA:
undetectable		 5ih0A-6ekiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epe PROTEASOME SUBUNIT
BETA TYPE-1

(Rattus
norvegicus) 		no annotation 5 HIS 6 190
GLY 6 181
SER 6 208
ILE 6 207
PHE 6 206
 None
 1.23A 5ih0A-6epe6:
undetectable		 5ih0A-6epe6:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6erc PEROXINECTIN A

(Dictyostelium
discoideum) 		no annotation 5 ILE A 170
GLY A 172
ASN A 173
ALA A 104
ILE A 243
 None
None
NA  A 609 (-3.3A)
HEM  A 604 ( 3.9A)
None
 1.21A 5ih0A-6ercA:
undetectable		 5ih0A-6ercA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X

(Clostridium
botulinum) 		no annotation 5 ILE A 239
GLY A 178
ASN A 293
GLU A 266
PHE A 244
 None
 1.24A 5ih0A-6f4eA:
undetectable		 5ih0A-6f4eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g1o -

(-) 		no annotation 5 ILE A 445
HIS A 448
GLU A 352
ALA A 375
ILE A 182
 None
 1.00A 5ih0A-6g1oA:
undetectable		 5ih0A-6g1oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4p PROTEIN (GLUTATHIONE
S-TRANSFERASE)

(Rattus
norvegicus) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 ASP A 161
HIS A  14
ILE A  16
TYR A   6
 None
 1.28A 5ih0A-1b4pA:
0.0		 5ih0A-1b4pA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cs3 ZINC FINGER PROTEIN
PLZF

(Homo sapiens) 		PF00651
(BTB) 		4 TYR A  88
ASP A  35
HIS A  48
ILE A  38
 None
 1.19A 5ih0A-1cs3A:
undetectable		 5ih0A-1cs3A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 ASP A  63
ILE A  57
TYR A  18
TYR A 388
 None
 1.23A 5ih0A-1dedA:
0.0		 5ih0A-1dedA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fob BETA-1,4-GALACTANASE

(Aspergillus
aculeatus) 		PF07745
(Glyco_hydro_53) 		4 ASP A  79
HIS A  81
ILE A 137
TYR A 215
 None
 1.04A 5ih0A-1fobA:
0.0		 5ih0A-1fobA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE

(Escherichia
virus Lambda) 		PF00149
(Metallophos) 		4 ASP A  20
HIS A 139
ILE A 183
TYR A 200
 MN  A1006 (-3.4A)
MN  A1005 (-3.4A)
None
None
 1.24A 5ih0A-1g5bA:
0.0		 5ih0A-1g5bA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtu GLUTATHIONE
S-TRANSFERASE

(Homo sapiens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ASP A 161
HIS A  14
ILE A  16
TYR A   6
 None
 1.24A 5ih0A-1gtuA:
0.0		 5ih0A-1gtuA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hh4 RHO GDP-DISSOCIATION
INHIBITOR 1

(Homo sapiens) 		PF02115
(Rho_GDI) 		4 ASP D 440
ILE D 429
TYR D 428
TYR D 410
 None
None
None
GER  D1502 (-4.9A)
 1.25A 5ih0A-1hh4D:
0.0		 5ih0A-1hh4D:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8t UDP-GALACTOPYRANOSE
MUTASE

(Escherichia
coli) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 TYR A 346
ILE A  57
TYR A 181
TYR A 151
 FAD  A 450 (-4.7A)
FAD  A 450 (-4.1A)
None
None
 0.95A 5ih0A-1i8tA:
0.0		 5ih0A-1i8tA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1noz DNA POLYMERASE

(Escherichia
virus T4) 		PF03104
(DNA_pol_B_exo1) 		4 TYR A 198
ASP A 137
HIS A 135
ILE A 184
 None
 1.23A 5ih0A-1nozA:
0.3		 5ih0A-1nozA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nx8 CARBAPENEM SYNTHASE

(Pectobacterium
carotovorum) 		PF02668
(TauD) 		4 TYR A 232
ASP A 240
HIS A 234
ILE A 243
 None
 1.19A 5ih0A-1nx8A:
undetectable		 5ih0A-1nx8A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otw COENZYME PQQ
SYNTHESIS PROTEIN C

(Klebsiella
pneumoniae) 		PF03070
(TENA_THI-4) 		4 TYR A 128
ASP A 186
ILE A  81
TYR A 175
 PQQ  A 500 (-4.6A)
None
None
PQQ  A 500 (-4.3A)
 1.30A 5ih0A-1otwA:
undetectable		 5ih0A-1otwA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pex COLLAGENASE-3

(Homo sapiens) 		PF00045
(Hemopexin) 		4 HIS A 337
ILE A 340
TYR A 332
TYR A 400
 None
 1.16A 5ih0A-1pexA:
undetectable		 5ih0A-1pexA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r47 ALPHA-GALACTOSIDASE
A

(Homo sapiens) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		4 ASP A 264
HIS A 225
ILE A 219
TYR A 184
 None
 1.20A 5ih0A-1r47A:
2.8		 5ih0A-1r47A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0b THUA-LIKE PROTEIN

(Geobacillus
stearothermophilus) 		PF06283
(ThuA) 		4 ASP A  19
HIS A  15
ILE A  25
TYR A 202
 None
 1.09A 5ih0A-1t0bA:
undetectable		 5ih0A-1t0bA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tw9 GLUTATHIONE
S-TRANSFERASE 2

(Heligmosomoides
polygyrus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 TYR A  98
ASP A 166
HIS A 163
ILE A 175
 None
 1.11A 5ih0A-1tw9A:
undetectable		 5ih0A-1tw9A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v33 DNA PRIMASE SMALL
SUBUNIT

(Pyrococcus
horikoshii) 		PF01896
(DNA_primase_S) 		4 TYR A 307
ASP A 140
HIS A 142
ILE A 152
 None
 1.19A 5ih0A-1v33A:
undetectable		 5ih0A-1v33A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w66 LIPOYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF03099
(BPL_LplA_LipB) 		4 TYR A  91
HIS A 157
ILE A 146
TYR A 105
 DKA  A 301 (-4.9A)
None
None
None
 1.28A 5ih0A-1w66A:
undetectable		 5ih0A-1w66A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzw PURPLE ACID
PHOSPHATASE

(Ipomoea batatas) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		4 TYR A 166
HIS A 324
ILE A 358
TYR A 252
 FE  A 429 ( 4.3A)
FE  A 429 ( 3.9A)
None
None
 1.29A 5ih0A-1xzwA:
undetectable		 5ih0A-1xzwA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zs8 HISTOCOMPATIBILITY
2, M REGION LOCUS
10.5

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 117
ASP A  90
HIS A  92
ILE A  11
 None
 1.20A 5ih0A-1zs8A:
undetectable		 5ih0A-1zs8A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axo HYPOTHETICAL PROTEIN
ATU2684

(Agrobacterium
fabrum) 		PF06764
(DUF1223) 		4 TYR A 114
ASP A 124
HIS A 125
ILE A 134
 None
 1.24A 5ih0A-2axoA:
undetectable		 5ih0A-2axoA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi7 UDP-GALACTOPYRANOSE
MUTASE

(Klebsiella
pneumoniae) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 TYR A 349
ILE A  61
TYR A 185
TYR A 155
 FAD  A1385 (-4.8A)
FAD  A1385 (-4.3A)
None
None
 1.00A 5ih0A-2bi7A:
undetectable		 5ih0A-2bi7A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csu 457AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF13380
(CoA_binding_2)
PF13607
(Succ_CoA_lig) 		4 ASP A 187
HIS A 118
ILE A 116
TYR A   4
 None
 1.25A 5ih0A-2csuA:
undetectable		 5ih0A-2csuA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjv ATP-DEPENDENT RNA
HELICASE DBPA

(Bacillus
subtilis) 		PF00271
(Helicase_C) 		4 TYR A 265
ASP A 233
ILE A 313
TYR A 315
 None
 1.19A 5ih0A-2hjvA:
undetectable		 5ih0A-2hjvA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2if5 ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 7A

(Homo sapiens) 		PF00651
(BTB) 		4 TYR A  92
ASP A  34
HIS A  47
ILE A  37
 None
 1.22A 5ih0A-2if5A:
undetectable		 5ih0A-2if5A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT
TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT

(Pseudomonas
stutzeri;
Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS)
PF02332
(Phenol_Hydrox) 		4 ASP A  66
ILE A  61
TYR A  58
TYR B 157
 None
 1.22A 5ih0A-2incA:
undetectable		 5ih0A-2incA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j64 FICOLIN-3

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		4 HIS A 172
ILE A 170
TYR A 177
TYR A  72
 None
 1.06A 5ih0A-2j64A:
undetectable		 5ih0A-2j64A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz G2/MITOTIC-SPECIFIC
CYCLIN-B1

(Homo sapiens) 		PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		4 HIS B 320
ILE B 412
TYR B 404
TYR B 224
 None
 1.23A 5ih0A-2jgzB:
undetectable		 5ih0A-2jgzB:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		4 ASP A 138
HIS A  66
TYR A 127
TYR A 266
 SO4  A1776 ( 4.7A)
SO4  A1776 (-4.2A)
None
SO4  A1776 (-4.8A)
 1.24A 5ih0A-2nsmA:
undetectable		 5ih0A-2nsmA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9t DING

(Pseudomonas
fluorescens) 		PF12849
(PBP_like_2) 		4 TYR A 301
HIS A  57
ILE A 296
TYR A  73
 None
 1.25A 5ih0A-2q9tA:
undetectable		 5ih0A-2q9tA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vat ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE

(Acremonium
chrysogenum) 		PF00561
(Abhydrolase_1) 		4 TYR A 336
ASP A 302
ILE A 123
TYR A 294
 None
 1.03A 5ih0A-2vatA:
undetectable		 5ih0A-2vatA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdu TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE-ASSOCI
ATED WD REPEAT
PROTEIN TRM82

(Saccharomyces
cerevisiae) 		no annotation 4 ASP B 234
HIS B 226
ILE B 204
TYR B 253
 None
 1.23A 5ih0A-2vduB:
1.4		 5ih0A-2vduB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg8 HYDROQUINONE
GLUCOSYLTRANSFERASE

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		4 TYR A 315
ASP A 117
HIS A  19
ILE A  21
 EDO  A1480 (-4.8A)
None
EDO  A1480 ( 3.8A)
UDP  A1477 (-3.7A)
 1.20A 5ih0A-2vg8A:
undetectable		 5ih0A-2vg8A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 TYR A 136
ASP A 109
ILE A  88
TYR A 128
 None
 1.25A 5ih0A-2z81A:
undetectable		 5ih0A-2z81A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 ASP A  63
ILE A  57
TYR A  18
TYR A 388
 None
 1.13A 5ih0A-3bmwA:
undetectable		 5ih0A-3bmwA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli) 		PF10672
(Methyltrans_SAM) 		4 TYR A 387
ASP A 375
HIS A 376
ILE A 105
 None
 1.29A 5ih0A-3c0kA:
undetectable		 5ih0A-3c0kA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dan CYTOCHROME P450 74A2

(Parthenium
argentatum) 		PF00067
(p450) 		4 TYR A 237
ASP A 263
HIS A 267
ILE A 269
 None
 1.08A 5ih0A-3danA:
undetectable		 5ih0A-3danA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg2 PUTATIVE RUBREDOXIN
REDUCTASE

(Rhodopseudomonas
palustris) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		4 TYR P 203
ASP P 192
HIS P 191
ILE P 186
 None
 0.88A 5ih0A-3fg2P:
undetectable		 5ih0A-3fg2P:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhl PUTATIVE
OXIDOREDUCTASE

(Bacteroides
fragilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 TYR A 309
HIS A  19
ILE A  34
TYR A  46
 None
 0.93A 5ih0A-3fhlA:
undetectable		 5ih0A-3fhlA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtu GLUTATHIONE
S-TRANSFERASE

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 ASP B 165
HIS B  18
ILE B  20
TYR B  10
 None
 1.30A 5ih0A-3gtuB:
undetectable		 5ih0A-3gtuB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzb PUTATIVE SNOAL-LIKE
POLYKETIDE CYCLASE

(Shewanella
putrefaciens) 		PF12680
(SnoaL_2) 		4 TYR A  28
ASP A 139
HIS A 137
ILE A  49
 None
MRD  A 154 (-4.6A)
None
None
 1.27A 5ih0A-3gzbA:
undetectable		 5ih0A-3gzbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hh8 METAL ABC
TRANSPORTER
SUBSTRATE-BINDING
LIPOPROTEIN

(Streptococcus
pyogenes) 		PF01297
(ZnuA) 		4 ASP A 280
ILE A  42
TYR A 150
TYR A 210
 FE  A 401 (-2.1A)
None
None
None
 1.27A 5ih0A-3hh8A:
undetectable		 5ih0A-3hh8A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hnp OXIDOREDUCTASE

(Bacillus cereus) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 TYR A 305
HIS A  18
ILE A  33
TYR A  46
 None
 1.13A 5ih0A-3hnpA:
undetectable		 5ih0A-3hnpA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hol TBPB

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 TYR A 215
ASP A 273
ILE A  65
TYR A 243
 None
 1.19A 5ih0A-3holA:
undetectable		 5ih0A-3holA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ASP A  83
ILE A  72
TYR A  68
TYR A  60
 None
None
None
EPE  A   1 (-4.6A)
 1.29A 5ih0A-3i4gA:
undetectable		 5ih0A-3i4gA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE

(Burkholderia
pseudomallei) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 TYR A 355
ASP A 349
ILE A 344
TYR A  38
 None
 1.30A 5ih0A-3imlA:
undetectable		 5ih0A-3imlA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1

(Cypovirus 1) 		no annotation 4 ASP B1167
HIS B1169
ILE B1171
TYR B1173
 None
 1.28A 5ih0A-3iz3B:
undetectable		 5ih0A-3iz3B:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN

(Klebsiella
pneumoniae) 		PF00149
(Metallophos) 		4 ASP A  61
HIS A  18
ILE A  63
TYR A 106
 MN  A 342 (-2.9A)
MN  A 340 (-3.5A)
None
None
 1.22A 5ih0A-3jyfA:
undetectable		 5ih0A-3jyfA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb6 D-LACTATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 TYR A  51
ASP A 255
HIS A 294
TYR A  96
 PPI  A 453 ( 4.7A)
NAD  A 400 (-4.1A)
LAC  A 399 (-3.9A)
LAC  A 399 ( 4.6A)
 1.09A 5ih0A-3kb6A:
undetectable		 5ih0A-3kb6A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus scrofa;
Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase)
PF00287
(Na_K-ATPase) 		4 TYR A1016
ILE A 991
TYR A 994
TYR B  39
 None
 1.24A 5ih0A-3n23A:
1.1		 5ih0A-3n23A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rp2 RAT MAST CELL
PROTEASE II

(Rattus rattus) 		PF00089
(Trypsin) 		4 TYR A 234
HIS A 101
ILE A  90
TYR A 215
 None
 1.01A 5ih0A-3rp2A:
undetectable		 5ih0A-3rp2A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2j DIPEPTIDASE

(Streptomyces
coelicolor) 		PF01244
(Peptidase_M19) 		4 TYR A 145
ASP A 320
HIS A  20
ILE A 317
 None
L3A  A 401 (-3.1A)
ZN  A 402 ( 3.3A)
None
 1.00A 5ih0A-3s2jA:
undetectable		 5ih0A-3s2jA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 TYR A 201
ASP A 140
HIS A 138
ILE A 187
 None
 1.20A 5ih0A-3sunA:
undetectable		 5ih0A-3sunA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrd FLAVOCYTOCHROME C
FLAVIN SUBUNIT

(Thermochromatium
tepidum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		4 TYR B 208
ASP B  52
HIS B 174
ILE B  49
 None
 1.10A 5ih0A-3vrdB:
undetectable		 5ih0A-3vrdB:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1g DNA LIGASE 4

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 ASP A 423
HIS A 482
ILE A 581
TYR A 570
 None
 1.01A 5ih0A-3w1gA:
undetectable		 5ih0A-3w1gA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1o DNA MIMIC PROTEIN
DMP12

(Neisseria
meningitidis) 		PF16779
(DMP12) 		4 TYR A  28
ASP A  71
HIS A 117
ILE A   8
 None
 1.18A 5ih0A-3w1oA:
undetectable		 5ih0A-3w1oA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9v PHOSPHATE-BINDING
PROTEIN

(unidentified
prokaryotic
organism) 		PF12849
(PBP_like_2) 		4 TYR A 307
HIS A  56
ILE A 302
TYR A  72
 None
 1.22A 5ih0A-3w9vA:
undetectable		 5ih0A-3w9vA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6q HISTONE DEACETYLASE
COMPLEX SUBUNIT
SAP18

(Mus musculus) 		PF06487
(SAP18) 		4 ASP A 134
HIS A  41
ILE A 137
TYR A  77
 None
None
None
IPA  A1144 (-3.8A)
 1.25A 5ih0A-4a6qA:
undetectable		 5ih0A-4a6qA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION

(Staphylothermus
marinus) 		PF00128
(Alpha-amylase) 		4 ASP A 272
HIS A 270
TYR A 229
TYR A 598
 None
 1.28A 5ih0A-4aeeA:
3.0		 5ih0A-4aeeA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A

(Aspergillus
nidulans) 		PF07745
(Glyco_hydro_53) 		4 ASP A  79
HIS A  81
ILE A 137
TYR A 215
 None
GOL  A1343 ( 4.6A)
None
ACT  A1336 (-4.0A)
 1.03A 5ih0A-4bf7A:
undetectable		 5ih0A-4bf7A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 TYR A 573
ASP A 630
HIS A 677
ILE A 603
 None
 1.16A 5ih0A-4d8mA:
undetectable		 5ih0A-4d8mA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dav SUGAR FERMENTATION
STIMULATION PROTEIN
HOMOLOG

(Pyrococcus
furiosus) 		PF03749
(SfsA) 		4 ASP A 117
HIS A 155
ILE A 171
TYR A 144
 None
 1.17A 5ih0A-4davA:
undetectable		 5ih0A-4davA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ee8 PRENYLTRANSFERASE

(Streptomyces
cinnamonensis) 		PF11468
(PTase_Orf2) 		4 TYR A 281
ASP A  60
ILE A 284
TYR A 174
 SO4  A 402 (-4.5A)
None
None
SO4  A 401 (-4.6A)
 1.25A 5ih0A-4ee8A:
undetectable		 5ih0A-4ee8A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fb5 PROBABLE
OXIDOREDUCTASE
PROTEIN

(Rhizobium etli) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 TYR A 182
HIS A 356
ILE A 370
TYR A 130
 None
 1.09A 5ih0A-4fb5A:
undetectable		 5ih0A-4fb5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzn BACTERIOCIN

(Pseudomonas
syringae group
genomosp. 3) 		PF14859
(Colicin_M) 		4 TYR A 120
ASP A  87
ILE A 103
TYR A   9
 None
 1.26A 5ih0A-4fznA:
undetectable		 5ih0A-4fznA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk8 HISTIDINOL-PHOSPHATA
SE

(Lactococcus
lactis) 		PF02811
(PHP) 		4 ASP A  17
HIS A  11
ILE A 231
TYR A 161
 ZN  A 302 ( 2.2A)
ZN  A 303 ( 3.3A)
None
None
 0.99A 5ih0A-4gk8A:
undetectable		 5ih0A-4gk8A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk8 HISTIDINOL-PHOSPHATA
SE

(Lactococcus
lactis) 		PF02811
(PHP) 		4 ASP A 228
HIS A   9
ILE A 194
TYR A 135
 ZN  A 303 ( 2.6A)
ZN  A 303 (-3.3A)
None
None
 1.12A 5ih0A-4gk8A:
undetectable		 5ih0A-4gk8A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 ASP A  63
ILE A  57
TYR A  18
TYR A 389
 None
 1.19A 5ih0A-4jclA:
2.4		 5ih0A-4jclA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqt PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF06439
(DUF1080) 		4 ASP A 344
HIS A 434
ILE A 336
TYR A 415
 None
 1.21A 5ih0A-4jqtA:
undetectable		 5ih0A-4jqtA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		4 ASP A 240
HIS A 218
ILE A 222
TYR A 289
 None
 1.17A 5ih0A-4kngA:
undetectable		 5ih0A-4kngA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpr THIOREDOXIN
REDUCTASE 1,
CYTOPLASMIC

(Rattus
norvegicus) 		no annotation 4 TYR E  11
HIS E 138
ILE E 140
TYR E 330
 None
 1.22A 5ih0A-4kprE:
undetectable		 5ih0A-4kprE:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kzy 40S RIBOSOMAL
PROTEIN S2

(Oryctolagus
cuniculus) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		4 TYR C  67
ASP C 117
HIS C 121
ILE C 115
 None
 1.10A 5ih0A-4kzyC:
undetectable		 5ih0A-4kzyC:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Xenopus
tropicalis) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 ASP A 234
HIS A 212
ILE A 216
TYR A 283
 None
 1.21A 5ih0A-4li2A:
undetectable		 5ih0A-4li2A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo2 UDP-GALACTOPYRANOSE
MUTASE

(Campylobacter
jejuni) 		no annotation 4 TYR B 345
ILE B  57
TYR B 180
TYR B 150
 FDA  B 402 (-4.6A)
FDA  B 402 (-4.2A)
None
None
 0.98A 5ih0A-4mo2B:
undetectable		 5ih0A-4mo2B:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL

(Homo sapiens) 		PF01416
(PseudoU_synth_1) 		4 ASP A 146
HIS A 292
ILE A 294
TYR A 203
 None
 1.19A 5ih0A-4nz6A:
undetectable		 5ih0A-4nz6A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o3x TRANSFERRIN BINDING
PROTEIN B

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17484
(TbpB_A) 		4 TYR B 215
ASP B 273
ILE B  65
TYR B 243
 None
 1.13A 5ih0A-4o3xB:
undetectable		 5ih0A-4o3xB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4x TBPB

(Glaesserella
parasuis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 TYR A 220
ASP A 278
ILE A  65
TYR A 248
 None
 1.15A 5ih0A-4o4xA:
undetectable		 5ih0A-4o4xA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oz5 BACILLUS SUBTILIS
HMOB

(Bacillus
subtilis) 		PF03992
(ABM) 		4 HIS A  50
ILE A  37
TYR A 162
TYR A 158
 None
 1.12A 5ih0A-4oz5A:
undetectable		 5ih0A-4oz5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE

(Chlamydia
trachomatis) 		PF00595
(PDZ)
PF03572
(Peptidase_S41) 		4 ASP A  58
HIS A 226
ILE A 224
TYR A 197
 None
 1.10A 5ih0A-4ql6A:
undetectable		 5ih0A-4ql6A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		4 TYR A 101
ASP A  98
HIS A  99
ILE A  57
 None
 1.17A 5ih0A-4qnyA:
5.0		 5ih0A-4qnyA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru5 TAILSPIKE GP27

(Pseudomonas
phage phi297) 		no annotation 4 TYR A 304
ASP A 473
HIS A 475
ILE A 481
 None
 1.27A 5ih0A-4ru5A:
undetectable		 5ih0A-4ru5A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whb PHENYLUREA HYDROLASE
B

(Mycolicibacterium
brisbanense) 		no annotation 4 ASP E 344
HIS E  67
ILE E 368
TYR E 401
 None
 1.06A 5ih0A-4whbE:
undetectable		 5ih0A-4whbE:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT
NA+,K+-ATPASE BETA
SUBUNIT

(Squalus
acanthias;
Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase)
PF00287
(Na_K-ATPase) 		4 TYR A1023
ILE A 998
TYR A1001
TYR B  40
 None
None
None
CLR  B3001 ( 4.0A)
 1.04A 5ih0A-5aw4A:
undetectable		 5ih0A-5aw4A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron) 		PF15979
(Glyco_hydro_115) 		4 ASP A 169
HIS A 216
ILE A 167
TYR A 344
 None
 1.12A 5ih0A-5by3A:
undetectable		 5ih0A-5by3A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c70 GLUCURONIDASE

(Aspergillus
oryzae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 HIS A 398
ILE A 186
TYR A 267
TYR A 176
 None
 1.21A 5ih0A-5c70A:
undetectable		 5ih0A-5c70A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doi TELOMERASE-ASSOCIATE
D PROTEIN 19

(Tetrahymena
thermophila) 		no annotation 4 ASP A   9
HIS A 142
ILE A 129
TYR A 130
 None
 1.18A 5ih0A-5doiA:
undetectable		 5ih0A-5doiA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5a GLUTATHIONE
S-TRANSFERASE U25

(Arabidopsis
thaliana) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 TYR A  73
ASP A   3
HIS A  59
ILE A   6
 None
 1.29A 5ih0A-5g5aA:
undetectable		 5ih0A-5g5aA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		4 TYR A  29
HIS A  61
ILE A 162
TYR A 165
 None
 1.30A 5ih0A-5gslA:
undetectable		 5ih0A-5gslA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdf HYDROLASE

(Streptomyces
flocculus) 		no annotation 4 TYR B 104
ASP B 308
HIS B 349
TYR B 360
 None
 1.05A 5ih0A-5hdfB:
undetectable		 5ih0A-5hdfB:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx0 DIPEPTIDASE

(Aspergillus
fumigatus) 		PF01244
(Peptidase_M19) 		4 TYR A 156
ASP A 294
HIS A  23
ILE A 291
 None
FE  A 402 (-3.9A)
FE  A 401 (-3.7A)
None
 1.15A 5ih0A-5lx0A:
undetectable		 5ih0A-5lx0A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mux 2-METHYLCITRATE
DEHYDRATASE

(Bacillus
subtilis) 		no annotation 4 ASP A  92
HIS A 104
ILE A  88
TYR A 203
 TLA  A 501 ( 4.9A)
TLA  A 501 (-4.0A)
None
None
 1.21A 5ih0A-5muxA:
undetectable		 5ih0A-5muxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndz LYSOZYME,PROTEINASE-
ACTIVATED RECEPTOR
2,SOLUBLE CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
PF07361
(Cytochrom_B562) 		4 TYR A 156
ASP A 228
HIS A 227
TYR A  82
 None
 1.12A 5ih0A-5ndzA:
undetectable		 5ih0A-5ndzA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nj6 PROTEINASE-ACTIVATED
RECEPTOR 2,SOLUBLE
CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		4 TYR A 156
ASP A 228
HIS A 227
TYR A  82
 None
 1.16A 5ih0A-5nj6A:
undetectable		 5ih0A-5nj6A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3

(Saccharomyces
cerevisiae) 		PF08238
(Sel1) 		4 TYR A 551
ILE A 217
TYR A 214
TYR A 507
 None
 1.00A 5ih0A-5v7vA:
undetectable		 5ih0A-5v7vA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvm CADHERIN-23

(Homo sapiens) 		no annotation 4 TYR A2186
ASP A2179
HIS A2178
ILE A2176
 None
 0.85A 5ih0A-5vvmA:
undetectable		 5ih0A-5vvmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzr ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bifidobacterium
bifidum) 		PF11308
(Glyco_hydro_129) 		4 ASP A 322
HIS A 366
TYR A 318
TYR A 550
 CA  A 703 (-2.1A)
CA  A 703 ( 3.3A)
None
None
 1.13A 5ih0A-5wzrA:
2.3		 5ih0A-5wzrA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xm3 GLUCOSE
DEHYDROGENASE

(Methylophaga
aminisulfidivorans) 		no annotation 4 TYR A 617
ASP A 110
ILE A 117
TYR A 554
 None
 1.11A 5ih0A-5xm3A:
undetectable		 5ih0A-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3y DENN
DOMAIN-CONTAINING
PROTEIN 3

(Mus musculus) 		no annotation 4 ASP A 756
HIS A 752
ILE A 750
TYR A 940
 None
 1.04A 5ih0A-6b3yA:
undetectable		 5ih0A-6b3yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)

(Homo sapiens) 		no annotation 4 ASP A1602
HIS A1597
ILE A1599
TYR A1628
 None
 1.21A 5ih0A-6bq1A:
6.2		 5ih0A-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eon BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 ASP A 427
HIS A 426
ILE A 422
TYR A 407
 None
 1.26A 5ih0A-6eonA:
undetectable		 5ih0A-6eonA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-) 		no annotation 4 TYR A 248
ASP A 161
ILE A 235
TYR A 505
 None
ACR  A 602 (-3.4A)
None
None
 1.30A 5ih0A-6gneA:
undetectable		 5ih0A-6gneA:
undetectable