SIMILAR PATTERNS OF AMINO ACIDS FOR 5IH0_A_ACTA402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxd PROTEIN (OSMOLARITY
SENSOR PROTEIN
(ENVZ))

(Escherichia
coli) 		PF02518
(HATPase_c) 		4 ARG A 383
PRO A 380
THR A 424
ILE A 378
 None
None
None
ANP  A 451 (-3.2A)
 1.21A 5ih0A-1bxdA:
undetectable		 5ih0A-1bxdA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)

(Homo sapiens) 		PF00168
(C2)
PF01735
(PLA2_B) 		4 PHE A 243
PRO A 241
THR A 236
ILE A 251
 None
 1.24A 5ih0A-1cjyA:
undetectable		 5ih0A-1cjyA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgp ARISTOLOCHENE
SYNTHASE

(Penicillium
roqueforti) 		no annotation 4 PRO A  41
ARG A 292
THR A 291
ILE A 246
 None
 1.25A 5ih0A-1dgpA:
undetectable		 5ih0A-1dgpA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1e HISTONE FOLD PROTEIN

(Methanopyrus
kandleri) 		PF00808
(CBFD_NFYB_HMF) 		4 PHE A  34
PRO A  36
THR A 116
ILE A  31
 None
 1.31A 5ih0A-1f1eA:
undetectable		 5ih0A-1f1eA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8p MAGNESIUM-CHELATASE
38 KDA SUBUNIT

(Rhodobacter
capsulatus) 		PF01078
(Mg_chelatase) 		4 PHE A  23
PRO A  22
THR A  60
ILE A  26
 None
 1.22A 5ih0A-1g8pA:
0.0		 5ih0A-1g8pA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzk HEROIN ESTERASE

(Rhodococcus sp.) 		PF07859
(Abhydrolase_3) 		4 PRO A 240
ARG A 272
THR A 244
ILE A 236
 None
 1.46A 5ih0A-1lzkA:
undetectable		 5ih0A-1lzkA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3b ENDONUCLEASE VIII

(Escherichia
coli) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		4 PHE A 148
ARG A 147
PRO A 146
THR A 117
 None
 0.96A 5ih0A-1q3bA:
1.8		 5ih0A-1q3bA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n UBIQUITIN-ACTIVATING
ENZYME E1C

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind) 		4 PHE B 213
PRO B 214
ARG B 223
ILE B 218
 None
 1.30A 5ih0A-1r4nB:
undetectable		 5ih0A-1r4nB:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sma MALTOGENIC AMYLASE

(Thermus sp.
IM6501) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 PHE A 219
PRO A 217
THR A 224
ILE A 215
 None
 1.40A 5ih0A-1smaA:
undetectable		 5ih0A-1smaA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6z HYPOTHETICAL PROTEIN
TTHA0657

(Thermus
thermophilus) 		PF04452
(Methyltrans_RNA) 		4 ARG A  63
PRO A  65
ARG A   5
THR A  36
 None
 1.04A 5ih0A-1v6zA:
undetectable		 5ih0A-1v6zA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbg PYRUVATE,ORTHOPHOSPH
ATE DIKINASE

(Zea mays) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 PHE A 705
PRO A 706
THR A 698
ILE A 741
 None
 1.01A 5ih0A-1vbgA:
undetectable		 5ih0A-1vbgA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl4 PMBA-RELATED PROTEIN

(Thermotoga
maritima) 		PF01523
(PmbA_TldD) 		4 PHE A 325
PRO A 331
THR A 321
ILE A 329
 None
 1.45A 5ih0A-1vl4A:
undetectable		 5ih0A-1vl4A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w18 LEVANSUCRASE

(Gluconacetobacter
diazotrophicus) 		PF02435
(Glyco_hydro_68) 		4 PHE A 445
PRO A 447
THR A 416
ILE A 391
 None
 1.38A 5ih0A-1w18A:
undetectable		 5ih0A-1w18A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE

(Saccharomyces
cerevisiae) 		PF01008
(IF-2B) 		4 PHE B 228
ARG B 264
PRO B 229
ILE B 256
 None
 1.32A 5ih0A-1w2wB:
undetectable		 5ih0A-1w2wB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 PRO B 417
ARG B 453
THR B 491
ILE B 378
 None
 1.17A 5ih0A-2a1aB:
8.4		 5ih0A-2a1aB:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb0 GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Pyrococcus
furiosus) 		PF01380
(SIS) 		4 PHE A 318
ARG A 317
PRO A 316
ILE A 214
 None
 1.32A 5ih0A-2cb0A:
undetectable		 5ih0A-2cb0A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3u HYPOTHETICAL PROTEIN
PH1566

(Pyrococcus
horikoshii) 		PF00013
(KH_1) 		4 PHE A 104
ARG A 108
PRO A 106
ARG A  44
 None
 1.32A 5ih0A-2e3uA:
undetectable		 5ih0A-2e3uA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5f HYPOTHETICAL PROTEIN
PH0510

(Pyrococcus
horikoshii) 		PF01380
(SIS) 		4 PHE A 318
ARG A 317
PRO A 316
ILE A 214
 None
 1.19A 5ih0A-2e5fA:
undetectable		 5ih0A-2e5fA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eax PEPTIDOGLYCAN
RECOGNITION
PROTEIN-I-BETA

(Homo sapiens) 		PF01510
(Amidase_2) 		4 ARG A 222
ARG A 216
THR A 224
ILE A 264
 None
 1.46A 5ih0A-2eaxA:
undetectable		 5ih0A-2eaxA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0a TRANSCRIPTIONAL
REGULATOR

(Thermus
thermophilus) 		PF13377
(Peripla_BP_3) 		4 PHE A 284
PRO A 283
ARG A 331
THR A 292
 None
 1.21A 5ih0A-2h0aA:
undetectable		 5ih0A-2h0aA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huo INOSITOL OXYGENASE

(Mus musculus) 		PF05153
(MIOX) 		4 PHE A 207
PRO A 280
THR A  72
ILE A 275
 None
 1.41A 5ih0A-2huoA:
undetectable		 5ih0A-2huoA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibn INOSITOL OXYGENASE

(Homo sapiens) 		PF05153
(MIOX) 		4 PHE A 207
PRO A 280
THR A  72
ILE A 275
 None
 1.41A 5ih0A-2ibnA:
undetectable		 5ih0A-2ibnA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1o GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sinapis alba) 		PF00348
(polyprenyl_synt) 		4 ARG A 270
PRO A 261
THR A 239
ILE A 235
 None
 1.44A 5ih0A-2j1oA:
undetectable		 5ih0A-2j1oA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5u MREC PROTEIN

(Listeria
monocytogenes) 		PF04085
(MreC) 		4 PHE A 233
PRO A 234
THR A 152
ILE A 237
 None
 1.17A 5ih0A-2j5uA:
undetectable		 5ih0A-2j5uA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jb1 L-AMINO ACID OXIDASE

(Rhodococcus
opacus) 		PF01593
(Amino_oxidase) 		4 PHE A 246
PRO A  22
THR A  91
ILE A 242
 None
FAD  A1489 (-3.7A)
None
None
 1.34A 5ih0A-2jb1A:
undetectable		 5ih0A-2jb1A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 PHE A1220
PRO A1346
ARG A1216
ILE A1245
 None
 1.34A 5ih0A-2nlkA:
undetectable		 5ih0A-2nlkA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind)
PF13416
(SBP_bac_8) 		4 PHE B2213
PRO B2214
ARG B2223
ILE B2218
 None
 1.31A 5ih0A-2nvuB:
undetectable		 5ih0A-2nvuB:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pe4 HYALURONIDASE-1

(Homo sapiens) 		PF01630
(Glyco_hydro_56) 		4 PHE A 347
PRO A 346
THR A 352
ILE A 348
 None
 1.32A 5ih0A-2pe4A:
undetectable		 5ih0A-2pe4A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfq 3-HSA HYDROXYLASE,
OXYGENASE

(Rhodococcus
jostii) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 PHE A  65
PRO A  62
THR A 236
ILE A 233
 None
 0.90A 5ih0A-2rfqA:
undetectable		 5ih0A-2rfqA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0f WSAF

(Geobacillus
stearothermophilus) 		no annotation 4 ARG A  83
PRO A 107
ARG A  40
ILE A  85
 None
 1.22A 5ih0A-2x0fA:
undetectable		 5ih0A-2x0fA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhf PEROXIREDOXIN 5

(Alvinella
pompejana) 		PF08534
(Redoxin) 		4 PHE A  58
PRO A  59
ARG A  65
ILE A  60
 None
 1.36A 5ih0A-2xhfA:
undetectable		 5ih0A-2xhfA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 PHE A 438
ARG A 467
PRO A 437
ILE A 473
 None
 1.39A 5ih0A-2xydA:
undetectable		 5ih0A-2xydA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186

(Pyrococcus
horikoshii) 		PF06745
(ATPase) 		4 PHE A 235
ARG A 216
THR A  45
ILE A 237
 None
ADP  A1903 (-4.0A)
ADP  A1903 (-3.7A)
ADP  A1903 (-3.8A)
 1.38A 5ih0A-2ztsA:
undetectable		 5ih0A-2ztsA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8t ADENYLATE
ISOPENTENYLTRANSFERA
SE

(Humulus lupulus) 		PF01715
(IPPT) 		4 PHE A 227
PRO A 225
THR A  73
ILE A 261
 None
 1.32A 5ih0A-3a8tA:
undetectable		 5ih0A-3a8tA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE

(Pseudomonas
putida) 		PF00202
(Aminotran_3) 		4 PHE X 400
PRO X 399
ARG X 391
ILE X 396
 None
 1.15A 5ih0A-3a8uX:
undetectable		 5ih0A-3a8uX:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clm TRANSALDOLASE

(Neisseria
gonorrhoeae) 		PF00923
(TAL_FSA) 		4 PHE A  47
PRO A  44
THR A  41
ILE A  46
 None
 1.39A 5ih0A-3clmA:
undetectable		 5ih0A-3clmA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddr HASR PROTEIN

(Serratia
marcescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 PRO A 135
ARG A 853
THR A 256
ILE A 259
 None
 1.27A 5ih0A-3ddrA:
undetectable		 5ih0A-3ddrA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 PHE A 486
PRO A 498
THR A 399
ILE A 500
 None
 1.42A 5ih0A-3fg4A:
undetectable		 5ih0A-3fg4A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ioq CMS1MS2

(Vasconcellea
cundinamarcensis) 		PF00112
(Peptidase_C1) 		4 PHE A 208
ARG A 124
PRO A 129
ILE A 127
 None
 1.46A 5ih0A-3ioqA:
undetectable		 5ih0A-3ioqA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isr TRANSGLUTAMINASE-LIK
E ENZYMES, PUTATIVE
CYSTEINE PROTEASE

(Cytophaga
hutchinsonii) 		PF01841
(Transglut_core) 		4 PHE A  69
PRO A  42
THR A  64
ILE A  44
 None
 1.14A 5ih0A-3isrA:
undetectable		 5ih0A-3isrA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixq RIBOSE-5-PHOSPHATE
ISOMERASE A

(Methanocaldococcus
jannaschii) 		PF06026
(Rib_5-P_isom_A) 		4 ARG A 161
PRO A 169
THR A 172
ILE A 178
 None
 1.35A 5ih0A-3ixqA:
undetectable		 5ih0A-3ixqA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		4 PHE B 475
PRO B 474
THR B 442
ILE B 476
 None
 1.44A 5ih0A-3k70B:
undetectable		 5ih0A-3k70B:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lic SENSOR PROTEIN

(Shewanella
oneidensis) 		PF02743
(dCache_1) 		4 PHE A 106
PRO A 104
ARG A 205
ILE A 100
 None
 1.42A 5ih0A-3licA:
undetectable		 5ih0A-3licA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lr2 MAJOR AMPULLATE
SPIDROIN 1

(Euprosthenops
australis) 		PF16763
(Spidroin_N) 		4 PHE A 116
PRO A 115
THR A 121
ILE A 117
 None
 1.23A 5ih0A-3lr2A:
undetectable		 5ih0A-3lr2A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdf DIPEPTIDYL PEPTIDASE
1

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08773
(CathepsinC_exc) 		4 PHE A 278
PRO A 279
THR A 379
ILE A 429
 LXV  A 442 ( 3.8A)
CL  A 443 ( 4.0A)
LXV  A 442 (-4.2A)
None
 1.27A 5ih0A-3pdfA:
1.7		 5ih0A-3pdfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE

(Salmonella
enterica) 		PF04131
(NanE) 		4 PHE A 104
PRO A  86
ARG A 111
ILE A  84
 None
 1.35A 5ih0A-3q58A:
undetectable		 5ih0A-3q58A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcc SORTASE SRTA

(Streptococcus
agalactiae) 		PF04203
(Sortase) 		4 PHE A  86
PRO A  69
THR A 100
ILE A  71
 None
 1.45A 5ih0A-3rccA:
undetectable		 5ih0A-3rccA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sm3 SAM-DEPENDENT
METHYLTRANSFERASES

(Methanosarcina
mazei) 		PF08241
(Methyltransf_11) 		4 PHE A 168
ARG A 171
THR A 178
ILE A 181
 None
 1.13A 5ih0A-3sm3A:
undetectable		 5ih0A-3sm3A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thc BETA-GALACTOSIDASE

(Homo sapiens) 		PF01301
(Glyco_hydro_35)
PF13364
(BetaGal_dom4_5) 		4 PHE A  63
PRO A 604
ARG A  68
THR A 369
 None
 1.36A 5ih0A-3thcA:
undetectable		 5ih0A-3thcA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw0 PECTINESTERASE

(Yersinia
enterocolitica) 		PF01095
(Pectinesterase) 		4 PHE A 202
PRO A 232
THR A 207
ILE A 201
 None
 1.31A 5ih0A-3uw0A:
undetectable		 5ih0A-3uw0A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		4 PHE A  83
PRO A  84
THR A 156
ILE A  85
 None
None
MG  A 401 (-2.9A)
None
 1.35A 5ih0A-3vpoA:
undetectable		 5ih0A-3vpoA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpq GLUTATHIONE
S-TRANSFERASE SIGMA

(Bombyx mori) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 PHE A   9
PRO A  10
ARG A  19
ILE A  34
 GSH  A 301 (-4.3A)
None
None
None
 1.39A 5ih0A-3vpqA:
undetectable		 5ih0A-3vpqA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxe GALECTIN-7

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 PRO A  10
ARG A  14
THR A  17
ILE A 134
 None
 1.39A 5ih0A-3zxeA:
undetectable		 5ih0A-3zxeA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aez WD REPEAT-CONTAINING
PROTEIN SLP1

(Schizosaccharomyces
pombe) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 PHE A 411
ARG A 438
PRO A 412
THR A 394
 None
 1.27A 5ih0A-4aezA:
undetectable		 5ih0A-4aezA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkd INTERLEUKIN-34

(Homo sapiens) 		PF15036
(IL34) 		4 PHE A  72
ARG A  79
THR A  78
ILE A  74
 NAG  A 301 (-4.5A)
NAG  A 301 (-3.3A)
None
None
 1.22A 5ih0A-4dkdA:
undetectable		 5ih0A-4dkdA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 PHE A 607
PRO A 606
ARG A 613
ILE A 608
 None
 1.20A 5ih0A-4fgvA:
undetectable		 5ih0A-4fgvA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l59 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE
PROTEIN 3

(Homo sapiens) 		PF02820
(MBT) 		4 PHE A 387
ARG A 434
THR A 435
ILE A 437
 None
 1.35A 5ih0A-4l59A:
undetectable		 5ih0A-4l59A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lss ENVELOPE
GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 PHE G 468
ARG G 350
THR G 358
ILE G 360
 None
None
NAG  G 512 (-2.8A)
None
 1.43A 5ih0A-4lssG:
undetectable		 5ih0A-4lssG:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ARG A 262
PRO A 260
ARG A 432
THR A 287
 None
None
PEG  A 504 (-4.0A)
None
 1.37A 5ih0A-4mrqA:
undetectable		 5ih0A-4mrqA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nj8 ANKYRIN REPEAT AND
SAM
DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF00536
(SAM_1) 		4 PHE A  53
ARG A  57
PRO A  55
THR A  60
 None
 1.37A 5ih0A-4nj8A:
undetectable		 5ih0A-4nj8A:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oer NIKA PROTEIN

(Brucella suis) 		PF00496
(SBP_bac_5) 		4 PHE A 207
ARG A 229
THR A 226
ILE A 215
 None
 1.35A 5ih0A-4oerA:
undetectable		 5ih0A-4oerA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR

(Bacillus
anthracis) 		PF00874
(PRD)
PF05043
(Mga)
PF08279
(HTH_11) 		4 PHE A 462
PRO A 463
THR A 398
ILE A 408
 None
 1.45A 5ih0A-4r6iA:
undetectable		 5ih0A-4r6iA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7b CHOLINE KINASE

(Streptococcus
pneumoniae) 		PF01633
(Choline_kinase) 		4 PHE A  47
ARG A  57
THR A  29
ILE A  55
 None
 1.36A 5ih0A-4r7bA:
17.3		 5ih0A-4r7bA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rd8 UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 PHE A  25
PRO A  24
THR A  30
ILE A  26
 None
 1.25A 5ih0A-4rd8A:
undetectable		 5ih0A-4rd8A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqx SORTASE

(Streptococcus
mutans) 		PF04203
(Sortase) 		4 PHE A 108
PRO A  91
THR A 122
ILE A  93
 None
 1.39A 5ih0A-4tqxA:
undetectable		 5ih0A-4tqxA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE

(Pseudomonas sp.) 		PF00202
(Aminotran_3) 		4 PHE A 400
PRO A 399
ARG A 391
ILE A 396
 None
 1.17A 5ih0A-4uhmA:
undetectable		 5ih0A-4uhmA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w66 GLUTATHIONE
S-TRANSFERASE DOMAIN
PROTEIN

(Haliangium
ochraceum) 		PF14497
(GST_C_3) 		4 PHE A  10
PRO A  11
ARG A  20
ILE A  35
 None
 1.28A 5ih0A-4w66A:
undetectable		 5ih0A-4w66A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 PHE A 231
PRO A 234
THR A 337
ILE A 235
 None
 1.42A 5ih0A-4w7sA:
undetectable		 5ih0A-4w7sA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 PHE A1043
PRO A1042
ARG A1096
ILE A1046
 None
 1.38A 5ih0A-4xgtA:
undetectable		 5ih0A-4xgtA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhg SIMILAR TO
UNIPROT|P29295
SACCHAROMYCES
CEREVISIAE YPL204W
HRR25

([Candida]
glabrata) 		PF00069
(Pkinase) 		4 ARG A 115
PRO A  66
ARG A 141
THR A 144
 None
 1.38A 5ih0A-4xhgA:
7.9		 5ih0A-4xhgA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydi ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 PHE G 468
ARG G 350
THR G 357
ILE G 360
 None
None
None
NAG  G 512 (-4.8A)
 1.44A 5ih0A-4ydiG:
undetectable		 5ih0A-4ydiG:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfm BETA-LACTAMASE

(Mycobacteroides
abscessus) 		PF13354
(Beta-lactamase2) 		4 PRO A 274
ARG A 281
THR A 280
ILE A 276
 None
 1.41A 5ih0A-4yfmA:
undetectable		 5ih0A-4yfmA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE

(Sinorhizobium
meliloti) 		PF06253
(MTTB) 		4 PHE A 274
PRO A 273
ARG A 354
ILE A 275
 UNL  A 601 ( 4.8A)
None
UNL  A 601 ( 3.0A)
None
 1.42A 5ih0A-4yycA:
undetectable		 5ih0A-4yycA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE

(Geobacillus
stearothermophilus) 		PF00232
(Glyco_hydro_1) 		4 PHE A 295
PRO A 293
THR A 167
ILE A 221
 None
 1.32A 5ih0A-4zfmA:
undetectable		 5ih0A-4zfmA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7t TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE

(Sulfolobus
acidocaldarius) 		no annotation 4 ARG A 206
PRO A 205
THR A 193
ILE A 157
 None
 1.28A 5ih0A-5a7tA:
undetectable		 5ih0A-5a7tA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6g AGR133CP

(Eremothecium
gossypii) 		PF10345
(Cohesin_load) 		4 ARG A 524
PRO A 532
THR A 490
ILE A 533
 None
 1.38A 5ih0A-5c6gA:
undetectable		 5ih0A-5c6gA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d73 GLUTATHIONE
S-TRANSFERASE

(Wuchereria
bancrofti) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 PHE A   8
PRO A   9
ARG A  18
ILE A  33
 GSH  A 301 (-4.9A)
None
None
None
 1.39A 5ih0A-5d73A:
undetectable		 5ih0A-5d73A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d73 GLUTATHIONE
S-TRANSFERASE

(Wuchereria
bancrofti) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 PHE A   8
PRO A   9
THR A   6
ILE A  33
 GSH  A 301 (-4.9A)
None
None
None
 1.30A 5ih0A-5d73A:
undetectable		 5ih0A-5d73A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl7 PORIN

(Acinetobacter
baumannii) 		PF03573
(OprD) 		4 PHE A 127
PRO A 128
ARG A  13
THR A  11
 None
 1.40A 5ih0A-5dl7A:
undetectable		 5ih0A-5dl7A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ek0 CHIMERA OF BACTERIAL
ION TRANSPORT
PROTEIN AND HUMAN
SODIUM CHANNEL
PROTEIN TYPE 9
SUBUNIT ALPHA

(Homo sapiens;
Arcobacter
butzleri) 		PF00520
(Ion_trans) 		4 PHE A1704
PRO A1703
THR A1709
ILE A1705
 None
 1.29A 5ih0A-5ek0A:
undetectable		 5ih0A-5ek0A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Pectobacterium
atrosepticum) 		PF01867
(Cas_Cas1) 		4 ARG A 296
PRO A 278
ARG A 153
ILE A 282
 None
 1.33A 5ih0A-5fclA:
undetectable		 5ih0A-5fclA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		4 PHE A 489
PRO A 488
ARG A 335
THR A 331
 None
 1.20A 5ih0A-5gslA:
undetectable		 5ih0A-5gslA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE

(Thermococcus
kodakarensis) 		PF02449
(Glyco_hydro_42) 		4 PHE A 485
PRO A 484
ARG A 333
THR A 329
 None
 1.35A 5ih0A-5gsmA:
undetectable		 5ih0A-5gsmA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw7 GLUCOSIDASE YGJK

(Escherichia
coli) 		PF01204
(Trehalase) 		4 PHE A 742
PRO A 740
THR A 289
ILE A 725
 BGC  A1003 (-4.2A)
None
None
None
 1.21A 5ih0A-5gw7A:
1.7		 5ih0A-5gw7A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2

(Arabidopsis
thaliana) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 PHE A 398
PRO A 399
ARG A 409
THR A 405
 None
 1.28A 5ih0A-5gxuA:
undetectable		 5ih0A-5gxuA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6b PUTATIVE SECRETED
LIPASE

(Streptomyces
sp. W007) 		PF01674
(Lipase_2) 		4 PHE A 176
PRO A 175
THR A 181
ILE A 177
 None
None
ACT  A 305 (-4.7A)
None
 1.39A 5ih0A-5h6bA:
undetectable		 5ih0A-5h6bA:
21.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II

(Escherichia
coli) 		PF01636
(APH) 		4 ARG A  49
PRO A  51
THR A  60
ILE A  90
 None
 0.42A 5ih0A-5iguA:
31.2		 5ih0A-5iguA:
99.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA

(Geobacillus
stearothermophilus) 		no annotation 4 PHE B  56
PRO B  59
THR B 147
ILE B  60
 None
 1.46A 5ih0A-5ivlB:
undetectable		 5ih0A-5ivlB:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy6 GENERAL
TRANSCRIPTION FACTOR
IIF SUBUNIT 2

(Homo sapiens) 		PF02270
(TFIIF_beta) 		4 PHE T  83
PRO T  82
ARG T  44
THR T  57
 None
 1.46A 5ih0A-5iy6T:
undetectable		 5ih0A-5iy6T:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jft CASPASE 3,
APOPTOSIS-RELATED
CYSTEINE PROTEASE A

(Danio rerio) 		PF00656
(Peptidase_C14) 		4 PHE A  58
PRO A  66
ARG A 212
THR A  70
 None
 1.36A 5ih0A-5jftA:
undetectable		 5ih0A-5jftA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 4 PHE A 192
PRO A 221
THR A 156
ILE A 219
 None
 1.13A 5ih0A-5lewA:
undetectable		 5ih0A-5lewA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		4 ARG A 734
ARG A 583
THR A 588
ILE A 719
 None
 1.21A 5ih0A-5ljoA:
undetectable		 5ih0A-5ljoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2

(Saccharomyces
cerevisiae) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 ARG A 296
PRO A 299
THR A 337
ILE A 342
 None
 1.22A 5ih0A-5lkdA:
undetectable		 5ih0A-5lkdA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6u PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		4 PHE A 932
PRO A 931
THR A 886
ILE A 933
 None
 1.39A 5ih0A-5m6uA:
6.1		 5ih0A-5m6uA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 4 PRO A 568
ARG A 590
THR A 592
ILE A 594
 None
CL  A 704 (-4.9A)
None
None
 1.45A 5ih0A-5opqA:
1.1		 5ih0A-5opqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhs 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 3

(Homo sapiens) 		PF01399
(PCI)
PF08375
(Rpn3_C) 		4 PRO V 343
ARG V 368
THR V 364
ILE V 333
 None
 1.24A 5ih0A-5vhsV:
undetectable		 5ih0A-5vhsV:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		no annotation 4 ARG A 149
ARG A 137
THR A  94
ILE A  92
 None
 1.43A 5ih0A-5w6mA:
undetectable		 5ih0A-5w6mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w81 CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Danio rerio) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		4 PHE A 158
ARG A 154
THR A1094
ILE A 155
 None
 1.24A 5ih0A-5w81A:
undetectable		 5ih0A-5w81A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yua ION TRANSPORT
PROTEIN

(Arcobacter
butzleri) 		no annotation 4 PHE A1201
PRO A1200
THR A1206
ILE A1202
 None
None
LMT  A1302 (-4.2A)
None
 1.29A 5ih0A-5yuaA:
undetectable		 5ih0A-5yuaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5znn SORTILIN

(Mus musculus) 		no annotation 4 PHE A  90
PRO A  88
THR A 549
ILE A 605
 None
 1.44A 5ih0A-5znnA:
2.5		 5ih0A-5znnA:
undetectable