SIMILAR PATTERNS OF AMINO ACIDS FOR 5IGZ_A_SPRA404_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h09 LYSOZYME

(Streptococcus
virus Cp1) 		PF01183
(Glyco_hydro_25)
PF01473
(CW_binding_1) 		5 ASP A  95
ARG A  63
ASN A 156
TYR A 153
ASP A  92
 None
 1.27A 5igzA-1h09A:
1.5		 5igzA-1h09A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o14 ANTI-ECFSIGMA
FACTOR, CHRR

(Marinobacter
hydrocarbonoclasticus) 		PF12973
(Cupin_7) 		5 ASP A 112
TYR A  85
ASP A 142
HIS A 140
GLU A 143
 None
 1.21A 5igzA-3o14A:
0.3		 5igzA-3o14A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 N-TERMINAL
ACETYLTRANSFERASE B
COMPLEX SUBUNIT NAT3

(Candida
albicans) 		PF08445
(FR47) 		5 ASP B  21
ARG B  85
ASN B  28
TYR B  57
MET B  59
 COA  B 202 ( 4.0A)
COA  B 202 (-3.3A)
None
None
None
 1.49A 5igzA-5k04B:
0.0		 5igzA-5k04B:
18.97