SIMILAR PATTERNS OF AMINO ACIDS FOR 5IGZ_A_SPRA404

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h09 LYSOZYME

(Streptococcus
virus Cp1) 		PF01183
(Glyco_hydro_25)
PF01473
(CW_binding_1) 		5 ASP A  95
ARG A  63
ASN A 156
TYR A 153
ASP A  92
 None
 1.27A 5igzA-1h09A:
1.5		 5igzA-1h09A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o14 ANTI-ECFSIGMA
FACTOR, CHRR

(Marinobacter
hydrocarbonoclasticus) 		PF12973
(Cupin_7) 		5 ASP A 112
TYR A  85
ASP A 142
HIS A 140
GLU A 143
 None
 1.21A 5igzA-3o14A:
0.3		 5igzA-3o14A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 N-TERMINAL
ACETYLTRANSFERASE B
COMPLEX SUBUNIT NAT3

(Candida
albicans) 		PF08445
(FR47) 		5 ASP B  21
ARG B  85
ASN B  28
TYR B  57
MET B  59
 COA  B 202 ( 4.0A)
COA  B 202 (-3.3A)
None
None
None
 1.49A 5igzA-5k04B:
0.0		 5igzA-5k04B:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkd SON OF SEVENLESS-1

(Homo sapiens) 		PF00617
(RasGEF)
PF00618
(RasGEF_N) 		5 LEU S 788
HIS S 827
ILE S 855
GLU S 857
VAL S 861
 None
 0.70A 5igzA-1bkdS:
undetectable		 5igzA-1bkdS:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvu PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermococcus
litoralis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 LEU A 122
ILE A 151
ILE A 108
PHE A  53
VAL A  52
 None
 1.47A 5igzA-1bvuA:
undetectable		 5igzA-1bvuA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ccw PROTEIN (GLUTAMATE
MUTASE)

(Clostridium
cochlearium) 		PF06368
(Met_asp_mut_E) 		5 LEU B 200
ILE B 211
HIS B 163
GLU B  11
PHE B  13
 None
 1.27A 5igzA-1ccwB:
0.0		 5igzA-1ccwB:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT

(Desulfovibrio
desulfuricans) 		PF00374
(NiFeSe_Hases) 		5 LEU B 496
ILE B  29
GLU B 329
VAL B 490
GLU B 375
 None
None
MG  B 901 ( 3.9A)
FNE  B 543 (-4.5A)
None
 1.45A 5igzA-1e3dB:
0.0		 5igzA-1e3dB:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee0 2-PYRONE SYNTHASE

(Gerbera hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 375
ARG A 355
ILE A  24
GLU A 243
VAL A 245
 None
 1.01A 5igzA-1ee0A:
0.0		 5igzA-1ee0A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtm GLUTAMATE
DEHYDROGENASE

(Pyrococcus
furiosus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 LEU A 122
ILE A 151
ILE A 108
PHE A  53
VAL A  52
 None
 1.47A 5igzA-1gtmA:
undetectable		 5igzA-1gtmA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg2 CLATHRIN ASSEMBLY
PROTEIN SHORT FORM

(Rattus
norvegicus) 		PF07651
(ANTH) 		5 HIS A  83
ILE A 247
GLU A 249
PHE A 250
VAL A 253
 None
 1.31A 5igzA-1hg2A:
undetectable		 5igzA-1hg2A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hx8 SYNAPSE-ENRICHED
CLATHRIN ADAPTOR
PROTEIN LAP

(Drosophila
melanogaster) 		PF07651
(ANTH) 		5 LEU A 214
HIS A  85
GLU A 263
PHE A 264
VAL A 267
 None
 1.42A 5igzA-1hx8A:
undetectable		 5igzA-1hx8A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii8 RAD50 ABC-ATPASE

(Pyrococcus
furiosus) 		PF13304
(AAA_21)
PF13476
(AAA_23) 		5 LEU B 859
ILE A  25
ILE B 798
GLU B 831
GLU B 823
 None
 1.25A 5igzA-1ii8B:
0.3		 5igzA-1ii8B:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ix5 FKBP

(Methanothermococcus
thermolithotrophicus) 		PF00254
(FKBP_C) 		5 LEU A  48
ILE A 149
GLU A 151
VAL A 153
GLU A  62
 None
 1.40A 5igzA-1ix5A:
undetectable		 5igzA-1ix5A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kuu CONSERVED PROTEIN

(Methanothermobacter) 		PF07826
(IMP_cyclohyd) 		5 LEU A  98
ILE A  80
ILE A 145
GLU A 152
GLU A 104
 None
 1.38A 5igzA-1kuuA:
undetectable		 5igzA-1kuuA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nq7 NUCLEAR RECEPTOR
ROR-BETA

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		5 LEU A 295
ILE A 280
GLU A 285
PHE A 283
GLU A 275
 None
 1.42A 5igzA-1nq7A:
undetectable		 5igzA-1nq7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oal SUPEROXIDE DISMUTASE

(Photobacterium
leiognathi) 		PF00080
(Sod_Cu) 		5 LEU A  92
GLU A  20
PHE A  30
VAL A  29
GLU A 116
 None
 1.42A 5igzA-1oalA:
undetectable		 5igzA-1oalA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2f RESPONSE REGULATOR

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		5 LEU A  77
ARG A 113
ILE A 106
GLU A 105
PHE A 102
 None
 1.48A 5igzA-1p2fA:
undetectable		 5igzA-1p2fA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vax URIC ACID OXIDASE

(Arthrobacter
globiformis) 		PF01014
(Uricase) 		5 LEU A  89
ILE A 146
ARG A 189
GLU A  24
VAL A  25
 None
 1.27A 5igzA-1vaxA:
0.2		 5igzA-1vaxA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495

(Pyrococcus
horikoshii) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		5 LEU A 128
ILE A 190
ILE A 115
VAL A  79
GLU A  68
 None
 1.27A 5igzA-1x3lA:
undetectable		 5igzA-1x3lA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1

(Homo sapiens) 		PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		5 LEU A 788
HIS A 827
ILE A 855
GLU A 857
VAL A 861
 None
 0.70A 5igzA-1xdvA:
2.9		 5igzA-1xdvA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6e RNA POLYMERASE SIGMA
FACTOR RPOD

(Thermus
thermophilus) 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4) 		5 LEU F 220
ILE F 198
ILE F  88
GLU F  87
GLU F  99
 None
 1.41A 5igzA-2a6eF:
undetectable		 5igzA-2a6eF:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 395
ILE A 549
HIS A 483
ARG A 356
VAL A 445
 TPP  A 602 (-3.4A)
None
None
None
None
 1.28A 5igzA-2ag1A:
undetectable		 5igzA-2ag1A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0p ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF12891
(Glyco_hydro_44) 		5 LEU A 207
ILE A 183
ILE A 258
GLU A 239
PHE A 257
 None
 1.34A 5igzA-2e0pA:
2.6		 5igzA-2e0pA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqj PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Leishmania
major) 		PF00160
(Pro_isomerase) 		5 LEU A 108
ARG A  37
GLU A  93
PHE A 139
VAL A 137
 None
 1.44A 5igzA-2hqjA:
undetectable		 5igzA-2hqjA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4n PROLINE-TRNA LIGASE

(Rhodopseudomonas
palustris) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 LEU A 182
ILE A 246
ILE A 286
GLU A 209
VAL A 283
 None
None
None
None
5CA  A 439 (-4.5A)
 1.42A 5igzA-2i4nA:
undetectable		 5igzA-2i4nA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu1 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5

(Homo sapiens) 		PF02020
(W2) 		5 LEU A 314
ILE A 293
ILE A 351
GLU A 349
GLU A 319
 None
 1.20A 5igzA-2iu1A:
undetectable		 5igzA-2iu1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2izo FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE

(Sulfolobus
solfataricus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 LEU A 175
ILE A 230
ILE A 207
GLU A 210
GLU A 151
 None
None
None
None
MG  A1349 ( 4.5A)
 1.48A 5igzA-2izoA:
undetectable		 5igzA-2izoA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxc PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX20

(Homo sapiens) 		PF00270
(DEAD) 		5 LEU A 250
ILE A 103
ILE A 226
GLU A 224
GLU A 212
 None
 1.11A 5igzA-2oxcA:
undetectable		 5igzA-2oxcA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q62 ARSH

(Sinorhizobium
meliloti) 		PF03358
(FMN_red) 		5 LEU A  76
ILE A 116
ILE A 124
VAL A  84
GLU A  91
 None
 1.34A 5igzA-2q62A:
undetectable		 5igzA-2q62A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA

(-) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A  11
ILE A   8
ILE A  65
GLU A  67
PHE A  69
 None
 1.29A 5igzA-2qgyA:
undetectable		 5igzA-2qgyA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rop COPPER-TRANSPORTING
ATPASE 2

(Homo sapiens) 		PF00403
(HMA) 		5 LEU A  24
ILE A  42
GLU A  39
VAL A  35
GLU A  79
 None
 1.21A 5igzA-2ropA:
undetectable		 5igzA-2ropA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		5 ILE G1563
HIS G1564
ARG G1413
PHE G1410
VAL G1392
 None
 1.17A 5igzA-2uv8G:
undetectable		 5igzA-2uv8G:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vkt CTP SYNTHASE 2

(Homo sapiens) 		PF00117
(GATase) 		5 ILE A 337
ILE A 393
PHE A 395
VAL A 521
GLU A 408
 None
 1.48A 5igzA-2vktA:
undetectable		 5igzA-2vktA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr5 GLYCOGEN OPERON
PROTEIN GLGX

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 LEU A 446
ILE A 428
ILE A 636
PHE A 637
VAL A 613
 None
 1.45A 5igzA-2vr5A:
undetectable		 5igzA-2vr5A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xi7 RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF15518
(L_protein_N) 		5 LEU A 120
ILE A  71
ILE A  90
GLU A 125
VAL A  87
 None
 1.40A 5igzA-2xi7A:
undetectable		 5igzA-2xi7A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4

(Homo sapiens) 		PF00443
(UCH) 		5 LEU A 320
ILE A 359
ILE A 868
PHE A 919
VAL A 917
 None
 1.41A 5igzA-2y6eA:
undetectable		 5igzA-2y6eA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bew MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
GLYCOPROTEIN
HAPLOTYPE B21

(Gallus gallus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 LEU A 176
HIS A   3
ILE A  50
GLU A  48
GLU A 170
 None
 1.22A 5igzA-3bewA:
undetectable		 5igzA-3bewA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6k PUTATIVE
AMINOTRANSFERASE

(Corynebacterium
diphtheriae) 		PF12897
(Aminotran_MocR) 		5 LEU A 331
ILE A 326
ILE A 389
GLU A 387
VAL A 353
 None
 1.43A 5igzA-3d6kA:
undetectable		 5igzA-3d6kA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9y PROFILIN

(Schizosaccharomyces
pombe) 		PF00235
(Profilin) 		5 LEU A  10
ILE A  21
ILE A  87
GLU A  85
GLU A 115
 None
 1.49A 5igzA-3d9yA:
undetectable		 5igzA-3d9yA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do5 HOMOSERINE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		5 LEU A 315
ILE A  27
ILE A   6
GLU A  85
GLU A  18
 None
 1.39A 5igzA-3do5A:
undetectable		 5igzA-3do5A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9l PRE-MRNA-PROCESSING-
SPLICING FACTOR 8

(Homo sapiens) 		PF12134
(PRP8_domainIV) 		5 LEU A1817
ILE A1809
ILE A1906
PHE A1902
VAL A1899
 None
 1.41A 5igzA-3e9lA:
undetectable		 5igzA-3e9lA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 LEU A 172
ILE A 228
ILE A  62
GLU A 118
VAL A 120
 None
None
None
None
DRK  A 384 (-4.5A)
 1.42A 5igzA-3eb0A:
7.5		 5igzA-3eb0A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3els PRE-MRNA LEAKAGE
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00498
(FHA) 		5 LEU A 180
ILE A 172
ILE A 200
GLU A  79
PHE A 201
 None
None
None
GOL  A 206 (-3.6A)
None
 1.43A 5igzA-3elsA:
undetectable		 5igzA-3elsA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR

(Shewanella
oneidensis) 		PF02661
(Fic)
PF13784
(Fic_N) 		5 LEU A 124
ARG A 138
ILE A 197
GLU A 195
GLU A 172
 None
 1.48A 5igzA-3eqxA:
undetectable		 5igzA-3eqxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez9 PARA

(Salmonella
enterica) 		PF13614
(AAA_31) 		5 LEU A 152
ILE A 204
ARG A 241
ILE A 233
GLU A 232
 None
None
None
None
MG  A 402 (-3.1A)
 1.50A 5igzA-3ez9A:
undetectable		 5igzA-3ez9A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9r PHOSPHOMANNOMUTASE

(Trypanosoma
brucei) 		PF03332
(PMM) 		5 ILE A 111
ARG A 151
ILE A 173
PHE A 179
VAL A 181
 None
 1.26A 5igzA-3f9rA:
undetectable		 5igzA-3f9rA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 211
ILE A 196
GLU A 201
PHE A 199
GLU A 191
 None
 1.18A 5igzA-3fs1A:
undetectable		 5igzA-3fs1A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Aquifex
aeolicus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		5 LEU B 372
ILE B 393
ARG B 356
GLU B 325
PHE B 329
 None
 1.43A 5igzA-3h0rB:
undetectable		 5igzA-3h0rB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd) 		5 LEU A  26
ILE A  56
GLU A  66
PHE A  67
VAL A  33
 None
 1.39A 5igzA-3h39A:
undetectable		 5igzA-3h39A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iau THREONINE DEAMINASE

(Solanum
lycopersicum) 		PF00291
(PALP) 		5 ILE A 209
ILE A 222
GLU A 242
VAL A 320
GLU A  82
 None
 1.49A 5igzA-3iauA:
undetectable		 5igzA-3iauA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iey NEQ261
TRNA-SPLICING
ENDONUCLEASE

(Nanoarchaeum
equitans) 		PF01974
(tRNA_int_endo)
PF02778
(tRNA_int_endo_N) 		5 LEU B 116
ILE A 147
ILE B 134
GLU B  62
GLU A 120
 None
 1.26A 5igzA-3ieyB:
undetectable		 5igzA-3ieyB:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksy SON OF SEVENLESS
HOMOLOG 1

(Homo sapiens) 		PF00125
(Histone)
PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		5 LEU A 788
HIS A 827
ILE A 855
GLU A 857
VAL A 861
 None
 0.88A 5igzA-3ksyA:
2.1		 5igzA-3ksyA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7p PUTATIVE NITROGEN
REGULATORY PROTEIN
PII

(Streptococcus
mutans) 		PF00543
(P-II) 		5 LEU A  20
ILE A  92
GLU A   5
VAL A  65
GLU A  73
 None
 1.42A 5igzA-3l7pA:
undetectable		 5igzA-3l7pA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7o ENDOGLUCANASE

(Thermotoga
maritima) 		PF01670
(Glyco_hydro_12) 		5 LEU A  20
ILE A 252
PHE A  13
VAL A   3
GLU A  68
 None
 1.50A 5igzA-3o7oA:
undetectable		 5igzA-3o7oA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3og9 PROTEIN YAHD A
COPPER INDUCIBLE
HYDROLASE

(Lactococcus
lactis) 		PF01738
(DLH) 		5 LEU A 190
HIS A 131
ILE A  36
GLU A  34
GLU A 193
 None
 1.41A 5igzA-3og9A:
undetectable		 5igzA-3og9A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3j GLUTAMATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 LEU A 112
ILE A  70
ILE A 494
PHE A 497
VAL A 500
 None
 1.30A 5igzA-3r3jA:
undetectable		 5igzA-3r3jA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2y SULFIDE-QUINONE
REDUCTASE, PUTATIVE

(Acidithiobacillus
ferrooxidans) 		PF07992
(Pyr_redox_2) 		5 LEU A 199
ILE A 196
PHE A 367
VAL A 355
GLU A 166
 None
 1.41A 5igzA-3t2yA:
undetectable		 5igzA-3t2yA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tg1 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10

(Homo sapiens) 		PF00581
(Rhodanese) 		5 LEU B 256
ILE B 175
ILE B 149
GLU B 242
GLU B 265
 None
 1.33A 5igzA-3tg1B:
undetectable		 5igzA-3tg1B:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trp CALSEQUESTRIN-1

(Oryctolagus
cuniculus) 		PF01216
(Calsequestrin) 		5 LEU A  33
ILE A  16
ILE A  95
GLU A 105
VAL A 103
 None
 1.28A 5igzA-3trpA:
undetectable		 5igzA-3trpA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CRISPR SYSTEM CMR
SUBUNIT CMR2

(Pyrococcus
furiosus) 		PF12469
(DUF3692) 		5 LEU A 780
ILE A 864
ILE A 838
GLU A 814
GLU A 775
 None
 1.46A 5igzA-3x1lA:
undetectable		 5igzA-3x1lA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8s ADP-DEPENDENT
GLUCOKINASE

(Thermococcus
litoralis) 		PF04587
(ADP_PFK_GK) 		5 LEU A 340
ILE A 346
ILE A 315
GLU A 319
GLU A 308
 None
None
None
None
GOL  A1468 (-2.9A)
 1.43A 5igzA-4b8sA:
undetectable		 5igzA-4b8sA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 LEU B 876
HIS B 421
ILE B 870
GLU B 444
VAL B 445
 None
 1.45A 5igzA-4f92B:
undetectable		 5igzA-4f92B:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1h SORTASE FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF04203
(Sortase) 		5 ILE A 193
ILE A 176
PHE A 177
VAL A 179
GLU A 233
 None
 1.45A 5igzA-4g1hA:
undetectable		 5igzA-4g1hA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grl MHC CLASS II
HLA-DQ-ALPHA CHAIN

(Homo sapiens) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		5 LEU A  12
ILE A 112
GLU A  85
PHE A 145
GLU A  25
 None
 1.50A 5igzA-4grlA:
undetectable		 5igzA-4grlA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4haq GH7 FAMILY PROTEIN

(Limnoria
quadripunctata) 		PF00840
(Glyco_hydro_7) 		5 LEU A 319
ILE A 313
ARG A 324
GLU A 233
GLU A 352
 None
 1.39A 5igzA-4haqA:
undetectable		 5igzA-4haqA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5a PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
F, MITOCHONDRIAL

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 LEU X 140
ARG X  79
GLU X 128
PHE X 171
VAL X 169
 None
 1.50A 5igzA-4j5aX:
undetectable		 5igzA-4j5aX:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6n AMINODEOXYCHORISMATE
LYASE

(Saccharomyces
cerevisiae) 		PF01063
(Aminotran_4) 		5 LEU A 334
ILE A 366
GLU A 285
PHE A 359
VAL A 303
 None
 1.48A 5igzA-4k6nA:
undetectable		 5igzA-4k6nA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kny KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE

(Escherichia
coli) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		5 LEU A  34
ILE A  61
ARG A  68
ILE A  49
GLU A   8
 None
 1.37A 5igzA-4knyA:
undetectable		 5igzA-4knyA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Methanocaldococcus
jannaschii) 		PF02350
(Epimerase_2) 		5 LEU A  16
ILE A   6
ILE A 357
GLU A 355
GLU A 117
 None
 1.08A 5igzA-4nesA:
undetectable		 5igzA-4nesA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s15 NUCLEAR RECEPTOR
ROR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 356
ILE A 341
GLU A 346
PHE A 344
GLU A 336
 None
 1.39A 5igzA-4s15A:
undetectable		 5igzA-4s15A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wum CHALCONE SYNTHASE

(Freesia hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 370
ARG A 350
ILE A  19
GLU A 238
VAL A 240
 None
 1.05A 5igzA-4wumA:
undetectable		 5igzA-4wumA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xaa PUTATIVE OXYGENASE

(Streptomyces
viridochromogenes) 		PF05721
(PhyH) 		5 LEU A  86
ILE A  32
ILE A 212
GLU A  76
GLU A  90
 None
 1.26A 5igzA-4xaaA:
undetectable		 5igzA-4xaaA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz6 GLYCINE
BETAINE/PROLINE ABC
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Ruegeria
pomeroyi) 		PF04069
(OpuAC) 		5 LEU A  99
ILE A 291
HIS A 125
GLU A  77
VAL A  79
 None
 1.49A 5igzA-4xz6A:
undetectable		 5igzA-4xz6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydh FORMIN-LIKE PROTEIN
1

(Homo sapiens) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		5 LEU A 261
GLU A 298
PHE A 296
VAL A 299
GLU A 311
 None
 1.21A 5igzA-4ydhA:
undetectable		 5igzA-4ydhA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avi OXYSTEROLS RECEPTOR
LXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 414
ILE A 339
GLU A 341
PHE A 342
GLU A 301
 None
4KM  A 501 ( 4.0A)
None
None
None
 1.49A 5igzA-5aviA:
undetectable		 5igzA-5aviA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d01 N-ACETYL-ALPHA-D-GLU
COSAMINYL L-MALATE
SYNTHASE

(Bacillus
subtilis) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		5 LEU A 290
ILE A 307
PHE A 285
VAL A 151
GLU A 356
 None
None
None
GMT  A 401 (-4.3A)
None
 1.44A 5igzA-5d01A:
undetectable		 5igzA-5d01A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5t ARGONAUTE

(Methanocaldococcus
jannaschii) 		PF02171
(Piwi) 		5 LEU A 503
ILE A 534
ILE A 592
GLU A 593
GLU A 577
 None
 1.16A 5igzA-5g5tA:
undetectable		 5igzA-5g5tA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5id6 CPF1

(Lachnospiraceae
bacterium
ND2006) 		no annotation 5 LEU A 839
ILE A 904
ILE A 922
VAL A 842
GLU A 925
 None
 1.26A 5igzA-5id6A:
undetectable		 5igzA-5id6A:
13.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II

(Escherichia
coli) 		PF01636
(APH) 		6 ARG A 237
ILE A 277
GLU A 279
PHE A 280
VAL A 283
GLU A 288
 None
 0.61A 5igzA-5iguA:
34.1		 5igzA-5iguA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikl GERANYL-COA
CARBOXYLASE,
BETA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF01039
(Carboxyl_trans) 		5 LEU B 341
ARG B 309
ILE B   4
GLU B 315
PHE B 316
 None
 1.23A 5igzA-5iklB:
2.3		 5igzA-5iklB:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5v IMMUNITY PROTEIN
CDII

(Escherichia
coli) 		no annotation 5 LEU C  56
ILE C  30
GLU C  41
VAL C  40
GLU C  36
 None
 1.42A 5igzA-5j5vC:
undetectable		 5igzA-5j5vC:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksh PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 LEU A 192
ILE A 275
GLU A 274
PHE A 449
GLU A 399
 None
 1.27A 5igzA-5kshA:
undetectable		 5igzA-5kshA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens) 		PF03538
(VRP1) 		5 LEU A2433
ILE A2507
ILE A2412
GLU A2473
PHE A2472
 None
 1.29A 5igzA-5lkiA:
undetectable		 5igzA-5lkiA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lw0 BASIC
HELIX-LOOP-HELIX,
PUTATIVE, EXPRESSED

(Oryza sativa) 		PF01661
(Macro) 		5 LEU A 185
ILE A  98
PHE A 172
VAL A 173
GLU A 248
 None
 1.45A 5igzA-5lw0A:
undetectable		 5igzA-5lw0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msn DCC1 PROTEIN

(Saccharomyces
cerevisiae) 		PF09724
(Dcc1) 		5 LEU A 266
ILE A 316
ILE A 277
GLU A 279
PHE A 280
 None
 1.24A 5igzA-5msnA:
undetectable		 5igzA-5msnA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE

(Enterobacter
cloacae) 		PF01977
(UbiD) 		5 LEU A 368
ILE A 387
GLU A 403
VAL A 405
GLU A 336
 None
None
GOL  A 501 ( 4.2A)
None
None
 1.48A 5igzA-5ny5A:
undetectable		 5igzA-5ny5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 HIS A 853
ILE A 616
GLU A 621
VAL A 622
GLU A 627
 None
 1.39A 5igzA-5o1pA:
undetectable		 5igzA-5o1pA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ols RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 LEU A 173
ILE A 161
GLU A 157
PHE A 159
VAL A 128
 None
 1.21A 5igzA-5olsA:
undetectable		 5igzA-5olsA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		5 LEU A1490
ILE A1523
PHE A1500
VAL A1501
GLU A1509
 None
 1.20A 5igzA-5u1sA:
undetectable		 5igzA-5u1sA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc5 CHS2 CHALCONE
SYNTHASE

(Malus domestica) 		no annotation 5 LEU A 283
ILE A 292
ILE A 301
PHE A 371
VAL A 379
 None
 1.47A 5igzA-5uc5A:
undetectable		 5igzA-5uc5A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm2 ALCOHOL
DEHYDROGENASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 HIS A 127
ARG A 122
ILE A  89
GLU A 152
GLU A  34
 None
None
None
MG  A 401 (-2.4A)
None
 1.40A 5igzA-5vm2A:
undetectable		 5igzA-5vm2A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxu 11S GLOBULIN

(Wrightia
tinctoria) 		no annotation 5 LEU A 181
ILE A 355
ILE A  67
VAL A  86
GLU A  53
 None
 1.41A 5igzA-5wxuA:
undetectable		 5igzA-5wxuA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co0 STYRYLPYRONE
SYNTHASE 1

(Piper
methysticum) 		no annotation 5 LEU A 284
ILE A 293
ILE A 302
PHE A 372
VAL A 380
 None
 1.47A 5igzA-6co0A:
undetectable		 5igzA-6co0A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 5 LEU A 474
ILE A 532
GLU A 450
PHE A 451
GLU A 462
 None
 1.49A 5igzA-6fikA:
undetectable		 5igzA-6fikA:
14.81