SIMILAR PATTERNS OF AMINO ACIDS FOR 5IGY_A_ERYA403_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bml STREPTOKINASE

(Streptococcus
dysgalactiae) 		PF02821
(Staphylokinase) 		4 ASP C 227
ILE C 230
ARG C 232
TYR C 243
 None
 1.46A 5igyA-1bmlC:
0.0		 5igyA-1bmlC:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cen CELLULASE CELC

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		4 TYR A 277
ILE A 300
TYR A 299
TYR A 200
 None
None
None
BGC  A 351 (-4.3A)
 1.24A 5igyA-1cenA:
undetectable		 5igyA-1cenA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)

(Homo sapiens) 		PF00168
(C2)
PF01735
(PLA2_B) 		4 ASP A 569
ILE A 561
ARG A 566
TYR A 223
 None
 1.26A 5igyA-1cjyA:
0.0		 5igyA-1cjyA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyg CYCLODEXTRIN
GLUCANOTRANSFERASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 ASP A  60
ILE A  54
TYR A  15
TYR A 384
 None
 1.05A 5igyA-1cygA:
0.0		 5igyA-1cygA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 ASP A  63
ILE A  57
TYR A  18
TYR A 388
 None
 1.11A 5igyA-1dedA:
0.0		 5igyA-1dedA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gll GLYCEROL KINASE

(Escherichia
coli) 		no annotation 4 ILE Y 425
ARG Y 389
TYR Y 483
TYR Y 355
 None
 1.19A 5igyA-1gllY:
0.0		 5igyA-1gllY:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3g CYCLOMALTODEXTRINASE

(Flavobacterium
sp. 92) 		PF00128
(Alpha-amylase)
PF09087
(Cyc-maltodext_N)
PF10438
(Cyc-maltodext_C) 		4 TYR A 450
ARG A 116
TYR A 180
TYR A 183
 None
 1.31A 5igyA-1h3gA:
2.3		 5igyA-1h3gA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hh4 RHO GDP-DISSOCIATION
INHIBITOR 1

(Homo sapiens) 		PF02115
(Rho_GDI) 		4 ASP D 440
ILE D 429
TYR D 428
TYR D 410
 None
None
None
GER  D1502 (-4.9A)
 1.29A 5igyA-1hh4D:
undetectable		 5igyA-1hh4D:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8t UDP-GALACTOPYRANOSE
MUTASE

(Escherichia
coli) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 TYR A 346
ILE A  57
TYR A 181
TYR A 151
 FAD  A 450 (-4.7A)
FAD  A 450 (-4.1A)
None
None
 0.89A 5igyA-1i8tA:
0.0		 5igyA-1i8tA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idu VANADIUM
CHLOROPEROXIDASE

(Curvularia
inaequalis) 		PF01569
(PAP2) 		4 ASP A  13
ILE A 472
ARG A 474
TYR A 288
 None
 1.35A 5igyA-1iduA:
undetectable		 5igyA-1iduA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 TYR A 274
ASP A 228
ILE A 253
TYR A  35
 None
 1.49A 5igyA-1iv8A:
2.5		 5igyA-1iv8A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcl CYCLODEXTRIN
GLYCOSYLTRANSFERASE

(Bacillus
circulans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 ASP A  63
ILE A  57
TYR A  18
TYR A 388
 None
 1.10A 5igyA-1kclA:
2.4		 5igyA-1kclA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1now BETA-HEXOSAMINIDASE
BETA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 TYR A 101
ILE A 283
ARG A 281
TYR A 277
 None
 1.42A 5igyA-1nowA:
undetectable		 5igyA-1nowA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otw COENZYME PQQ
SYNTHESIS PROTEIN C

(Klebsiella
pneumoniae) 		PF03070
(TENA_THI-4) 		4 TYR A 128
ASP A 186
ILE A  81
TYR A 175
 PQQ  A 500 (-4.6A)
None
None
PQQ  A 500 (-4.3A)
 1.20A 5igyA-1otwA:
undetectable		 5igyA-1otwA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pca PROCARBOXYPEPTIDASE
A PCPA

(Sus scrofa) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		4 TYR A 198
ASP A  36
ILE A  52
TYR A 248
 None
None
None
VAL  A 700 (-4.8A)
 1.26A 5igyA-1pcaA:
undetectable		 5igyA-1pcaA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450

(Sulfurisphaera
tokodaii) 		PF00067
(p450) 		4 ASP A 225
ILE A 299
ARG A 302
TYR A   2
 None
 1.03A 5igyA-1ue8A:
undetectable		 5igyA-1ue8A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 TYR A 606
ILE A  81
ARG A 373
TYR A 912
 NAG  A3001 (-4.6A)
None
None
EDO  A9004 ( 3.4A)
 1.40A 5igyA-1xc6A:
2.2		 5igyA-1xc6A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z14 VP2

(Rodent
protoparvovirus
1) 		PF00740
(Parvo_coat) 		4 TYR A 376
ASP A 399
ILE A 578
TYR A 558
 None
 1.32A 5igyA-1z14A:
undetectable		 5igyA-1z14A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4e CORONIN-1A

(Mus musculus) 		PF00400
(WD40)
PF08953
(DUF1899)
PF16300
(WD40_4) 		4 ASP A 278
ILE A 390
ARG A 325
TYR A 321
 None
 1.47A 5igyA-2b4eA:
3.8		 5igyA-2b4eA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi7 UDP-GALACTOPYRANOSE
MUTASE

(Klebsiella
pneumoniae) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 TYR A 349
ILE A  61
TYR A 185
TYR A 155
 FAD  A1385 (-4.8A)
FAD  A1385 (-4.3A)
None
None
 0.95A 5igyA-2bi7A:
undetectable		 5igyA-2bi7A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens;
Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2)
no annotation 		4 TYR A  68
ILE I 251
ARG I 249
TYR I 245
 None
 1.47A 5igyA-2gk1A:
undetectable		 5igyA-2gk1A:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 ASP I 175
ARG I 424
TYR N 456
TYR N 547
 None
 1.09A 5igyA-2gk1I:
undetectable		 5igyA-2gk1I:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjv ATP-DEPENDENT RNA
HELICASE DBPA

(Bacillus
subtilis) 		PF00271
(Helicase_C) 		4 TYR A 265
ASP A 233
ILE A 313
TYR A 315
 None
 1.17A 5igyA-2hjvA:
undetectable		 5igyA-2hjvA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6t DNAB REPLICATION
FORK HELICASE

(Thermus
aquaticus) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		4 ASP A 378
ILE A 414
ARG A 373
TYR A 396
 None
 1.08A 5igyA-2q6tA:
undetectable		 5igyA-2q6tA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qik UPF0131 PROTEIN YKQA

(Bacillus
subtilis) 		PF06094
(GGACT)
PF13772
(AIG2_2) 		4 TYR A 259
ASP A 149
ILE A 194
TYR A 131
 None
 1.39A 5igyA-2qikA:
undetectable		 5igyA-2qikA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 TYR A 136
ASP A 109
ILE A  88
TYR A 128
 None
 1.29A 5igyA-2z81A:
undetectable		 5igyA-2z81A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zf5 GLYCEROL KINASE

(Thermococcus
kodakarensis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ILE O 416
ARG O 382
TYR O 474
TYR O 348
 None
 1.28A 5igyA-2zf5O:
undetectable		 5igyA-2zf5O:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apq DNAJ HOMOLOG
SUBFAMILY C MEMBER
10

(Mus musculus) 		PF00085
(Thioredoxin)
PF00226
(DnaJ) 		4 TYR A 154
ASP A 126
TYR A 117
TYR A  84
 None
 1.35A 5igyA-3apqA:
undetectable		 5igyA-3apqA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgw DNAB-LIKE
REPLICATIVE HELICASE

(Bacillus phage
SPP1) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		4 ASP A 373
ILE A 409
ARG A 368
TYR A 391
 None
 1.03A 5igyA-3bgwA:
undetectable		 5igyA-3bgwA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh0 DNAB-LIKE
REPLICATIVE HELICASE

(Bacillus phage
SPP1) 		PF03796
(DnaB_C) 		4 ASP A 373
ILE A 409
ARG A 368
TYR A 391
 None
 1.00A 5igyA-3bh0A:
undetectable		 5igyA-3bh0A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjd PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE

(Pseudomonas
aeruginosa) 		PF14515
(HOASN)
PF14518
(Haem_oxygenas_2) 		4 ASP A 157
ARG A 150
TYR A 316
TYR A  65
 None
None
None
EDO  A 401 (-3.5A)
 1.44A 5igyA-3bjdA:
undetectable		 5igyA-3bjdA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		4 ASP A 168
ILE A 162
ARG A 161
TYR A 104
 None
 1.48A 5igyA-3blwA:
undetectable		 5igyA-3blwA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 ASP A  63
ILE A  57
TYR A  18
TYR A 388
 None
 1.04A 5igyA-3bmwA:
2.3		 5igyA-3bmwA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsm UNCHARACTERIZED
PROTEIN BACUNI_02894

(Bacteroides
uniformis) 		no annotation 4 ASP A 302
ARG A 279
TYR A 310
TYR A 323
 None
 1.11A 5igyA-3dsmA:
2.8		 5igyA-3dsmA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwk PENICILLIN-BINDING
PROTEIN 2

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		4 ASP A 241
ARG A 283
TYR A 210
TYR A 196
 None
SO4  A  22 (-2.9A)
None
None
 1.14A 5igyA-3dwkA:
undetectable		 5igyA-3dwkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris) 		PF08241
(Methyltransf_11) 		4 TYR A 158
ASP A 188
ARG A 149
TYR A  17
 None
None
None
SAM  A 221 (-3.8A)
 1.21A 5igyA-3e23A:
undetectable		 5igyA-3e23A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE

(Pseudomonas
putida) 		PF00180
(Iso_dh) 		4 ASP X 177
ILE X 171
ARG X 170
TYR X 104
 None
 1.23A 5igyA-3fmxX:
undetectable		 5igyA-3fmxX:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g25 GLYCEROL KINASE

(Staphylococcus
aureus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ILE A 424
ARG A 388
TYR A 482
TYR A 354
 None
 1.18A 5igyA-3g25A:
undetectable		 5igyA-3g25A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwj ARYLPHORIN

(Antheraea
pernyi) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 TYR A 573
ILE A 150
TYR A 129
TYR A 110
 None
 1.39A 5igyA-3gwjA:
undetectable		 5igyA-3gwjA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn7 UDP-N-ACETYLMURAMATE
-L-ALANINE LIGASE

(Psychrobacter
arcticus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 TYR A  53
ILE A  34
TYR A  35
TYR A 430
 None
 1.29A 5igyA-3hn7A:
undetectable		 5igyA-3hn7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hol TBPB

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 TYR A 215
ASP A 273
ILE A  65
TYR A 243
 None
 1.11A 5igyA-3holA:
undetectable		 5igyA-3holA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1i HOMOSERINE
O-ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		4 ASP A  89
ILE A  86
TYR A  31
TYR A  58
 None
 1.42A 5igyA-3i1iA:
undetectable		 5igyA-3i1iA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE

(Burkholderia
pseudomallei) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 TYR A 355
ASP A 349
ILE A 344
TYR A  38
 None
 1.27A 5igyA-3imlA:
undetectable		 5igyA-3imlA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8n POSSIBLE GLUTATHIONE
S-TRANSFERASE

(Rhodopseudomonas
palustris) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 TYR A 164
ASP A 171
ILE A 106
TYR A 110
 None
 1.39A 5igyA-3m8nA:
undetectable		 5igyA-3m8nA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus scrofa;
Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase)
PF00287
(Na_K-ATPase) 		4 TYR A1016
ILE A 991
TYR A 994
TYR B  39
 None
 1.27A 5igyA-3n23A:
undetectable		 5igyA-3n23A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n77 NUCLEOSIDE
TRIPHOSPHATASE NUDI

(Salmonella
enterica) 		PF00293
(NUDIX) 		4 ILE A  95
ARG A  73
TYR A  93
TYR A  90
 None
 1.45A 5igyA-3n77A:
undetectable		 5igyA-3n77A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2k BREVIANAMIDE F
PRENYLTRANSFERASE

(Aspergillus
fumigatus) 		PF11991
(Trp_DMAT) 		4 TYR A 446
ASP A 191
ILE A 112
TYR A 203
 DST  A 501 (-4.7A)
DST  A 501 ( 4.1A)
None
QRP  A 502 ( 3.4A)
 1.28A 5igyA-3o2kA:
undetectable		 5igyA-3o2kA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otn SUSD SUPERFAMILY
PROTEIN

(Parabacteroides
distasonis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 TYR A 184
ILE A 156
TYR A 152
TYR A 382
 None
 1.25A 5igyA-3otnA:
undetectable		 5igyA-3otnA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbo PHOSPHOSERINE
AMINOTRANSFERASE

(Yersinia pestis) 		PF00266
(Aminotran_5) 		4 ASP A 160
ILE A 291
ARG A 294
TYR A 276
 None
 1.02A 5igyA-3qboA:
undetectable		 5igyA-3qboA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 ASP A  38
ILE A 365
TYR A 146
TYR A 125
 None
None
None
Z99  A 485 ( 4.2A)
 1.30A 5igyA-3sm9A:
undetectable		 5igyA-3sm9A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssz MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Rhodobacteraceae
bacterium KLH11) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A 196
ILE A 169
TYR A 346
TYR A 374
 None
 1.46A 5igyA-3sszA:
undetectable		 5igyA-3sszA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stp GALACTONATE
DEHYDRATASE,
PUTATIVE

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A 173
ILE A 146
TYR A 323
TYR A 351
 None
 1.48A 5igyA-3stpA:
undetectable		 5igyA-3stpA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
ALPHA CHAIN
V-TYPE ATP SYNTHASE
BETA CHAIN

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 TYR A 353
ILE D  14
ARG A  41
TYR D  13
 None
 1.47A 5igyA-3w3aA:
undetectable		 5igyA-3w3aA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdg URACIL-DNA
GLYCOSYLASE

(Staphylococcus
aureus) 		PF03167
(UDG) 		4 ASP A 106
ILE A 211
TYR A 196
TYR A  88
 None
 1.33A 5igyA-3wdgA:
undetectable		 5igyA-3wdgA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wp9 ICE-BINDING PROTEIN

(Colwellia sp.
SLW05) 		PF11999
(DUF3494) 		4 ASP A  95
ILE A 137
ARG A  91
TYR A   4
 None
 1.25A 5igyA-3wp9A:
undetectable		 5igyA-3wp9A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 TYR A 405
ASP A 422
ILE A 373
TYR A  93
 None
 1.26A 5igyA-3zo9A:
2.8		 5igyA-3zo9A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpy ALGINATE LYASE,
FAMILY PL7

(Zobellia
galactanivorans) 		PF08787
(Alginate_lyase2) 		4 TYR A 420
ASP A 335
ILE A 322
TYR A 414
 None
 1.25A 5igyA-3zpyA:
undetectable		 5igyA-3zpyA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1f REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF03796
(DnaB_C) 		4 ASP A 371
ILE A 441
ARG A 366
TYR A 389
 None
 1.02A 5igyA-4a1fA:
undetectable		 5igyA-4a1fA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION

(Staphylothermus
marinus) 		PF00128
(Alpha-amylase) 		4 ASP A 272
ILE A 267
TYR A 229
TYR A 598
 None
 1.36A 5igyA-4aeeA:
undetectable		 5igyA-4aeeA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aef NEOPULLULANASE
(ALPHA-AMYLASE II)

(Pyrococcus
furiosus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16561
(AMPK1_CBM) 		4 TYR A 456
ILE A 435
TYR A 257
TYR A 270
 None
 1.47A 5igyA-4aefA:
undetectable		 5igyA-4aefA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ee8 PRENYLTRANSFERASE

(Streptomyces
cinnamonensis) 		PF11468
(PTase_Orf2) 		4 TYR A 281
ASP A  60
ILE A 284
TYR A 174
 SO4  A 402 (-4.5A)
None
None
SO4  A 401 (-4.6A)
 1.30A 5igyA-4ee8A:
undetectable		 5igyA-4ee8A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4en8 HEMAGGLUTININ
COMPONENTS
HA-22/23/53

(Clostridium
botulinum) 		PF03505
(Clenterotox) 		4 TYR B 613
ILE B 316
TYR B 214
TYR B 429
 None
 1.46A 5igyA-4en8B:
undetectable		 5igyA-4en8B:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcy TRANSPOSASE

(Escherichia
virus Mu) 		PF02316
(HTH_Tnp_Mu_1)
PF02914
(DDE_2)
PF09039
(HTH_Tnp_Mu_2)
PF09299
(Mu-transpos_C) 		4 ASP A 306
ILE A 311
ARG A 315
TYR A 354
 None
 1.04A 5igyA-4fcyA:
undetectable		 5igyA-4fcyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwb HALOALKANE
DEHALOGENASE

(Rhodococcus
rhodochrous) 		PF00561
(Abhydrolase_1) 		4 TYR A 225
ASP A 106
ILE A 247
ARG A 133
 None
3KP  A2001 ( 2.3A)
None
None
 1.00A 5igyA-4fwbA:
undetectable		 5igyA-4fwbA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4s PROTEASOME ASSEMBLY
CHAPERONE 2

(Saccharomyces
cerevisiae) 		PF09754
(PAC2) 		4 TYR P  59
ASP P  20
ILE P 247
ARG P  50
 None
 1.38A 5igyA-4g4sP:
undetectable		 5igyA-4g4sP:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F

(Bacillus
subtilis) 		PF12895
(ANAPC3)
PF13424
(TPR_12) 		4 ASP A 338
ARG A 115
TYR A 300
TYR A 226
 None
 1.40A 5igyA-4i9cA:
undetectable		 5igyA-4i9cA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 ASP A  80
ILE A  85
TYR A 379
TYR A 603
 None
None
None
NAG  A1137 (-4.7A)
 1.48A 5igyA-4iugA:
2.3		 5igyA-4iugA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 ASP A  63
ILE A  57
TYR A  18
TYR A 389
 None
 1.06A 5igyA-4jclA:
2.2		 5igyA-4jclA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 TYR A 360
ARG A  24
TYR A  97
TYR A 100
 None
None
None
GOL  A 711 ( 4.0A)
 1.29A 5igyA-4jclA:
2.2		 5igyA-4jclA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo0 CMLA

(Streptomyces
venezuelae) 		PF12706
(Lactamase_B_2) 		4 ASP A 403
ILE A 432
ARG A 457
TYR A 440
 FE  A 602 ( 2.6A)
None
None
None
 1.46A 5igyA-4jo0A:
undetectable		 5igyA-4jo0A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo2 UDP-GALACTOPYRANOSE
MUTASE

(Campylobacter
jejuni) 		no annotation 4 TYR B 345
ILE B  57
TYR B 180
TYR B 150
 FDA  B 402 (-4.6A)
FDA  B 402 (-4.2A)
None
None
 0.91A 5igyA-4mo2B:
undetectable		 5igyA-4mo2B:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ncj DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		4 ASP A  41
ILE A  71
ARG A  86
TYR A 129
 None
 1.24A 5igyA-4ncjA:
undetectable		 5igyA-4ncjA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o3x TRANSFERRIN BINDING
PROTEIN B

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17484
(TbpB_A) 		4 TYR B 215
ASP B 273
ILE B  65
TYR B 243
 None
 1.11A 5igyA-4o3xB:
undetectable		 5igyA-4o3xB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4x TBPB

(Glaesserella
parasuis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 TYR A 220
ASP A 278
ILE A  65
TYR A 248
 None
 1.07A 5igyA-4o4xA:
undetectable		 5igyA-4o4xA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8u UNCHARACTERIZED
PROTEIN PF2046

(Pyrococcus
furiosus) 		PF13680
(DUF4152) 		4 TYR A  58
ASP A  15
ILE A  66
ARG A  63
 None
 1.12A 5igyA-4o8uA:
undetectable		 5igyA-4o8uA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oz5 BACILLUS SUBTILIS
HMOB

(Bacillus
subtilis) 		PF03992
(ABM) 		4 TYR A  52
ASP A 111
ILE A  72
TYR A 158
 None
 1.28A 5igyA-4oz5A:
undetectable		 5igyA-4oz5A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE

(Escherichia
coli) 		PF06315
(AceK) 		4 TYR A  86
ASP A  18
ILE A  98
TYR A  54
 None
 1.49A 5igyA-4p69A:
5.8		 5igyA-4p69A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qre METHIONYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 TYR A 127
ARG A 217
TYR A 235
TYR A  14
 None
None
3BG  A 601 (-4.7A)
3BG  A 601 (-3.5A)
 1.40A 5igyA-4qreA:
undetectable		 5igyA-4qreA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru5 TAILSPIKE GP27

(Pseudomonas
phage phi297) 		no annotation 4 TYR A 384
ASP A 473
ILE A 417
TYR A 304
 None
 1.30A 5igyA-4ru5A:
undetectable		 5igyA-4ru5A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufc GH95

(Bacteroides
ovatus) 		PF14498
(Glyco_hyd_65N_2) 		4 TYR A 657
ASP A 670
ILE A 615
ARG A 655
 None
 1.27A 5igyA-4ufcA:
undetectable		 5igyA-4ufcA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN ALPHA-V
INTEGRIN BETA-6

(Homo sapiens;
Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		4 TYR B 292
ASP A 219
ILE B 219
TYR B 321
 None
 1.36A 5igyA-4um8B:
undetectable		 5igyA-4um8B:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uop LIPOTEICHOIC ACID
PRIMASE

(Listeria
monocytogenes) 		PF00884
(Sulfatase) 		4 TYR A 453
ILE A 232
TYR A 386
TYR A 338
 None
 1.32A 5igyA-4uopA:
undetectable		 5igyA-4uopA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		4 TYR A 193
ASP A 298
ILE A 274
TYR A 122
 None
 1.48A 5igyA-4us4A:
undetectable		 5igyA-4us4A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Pyrococcus
horikoshii) 		PF01867
(Cas_Cas1) 		4 ASP A  39
ILE A  42
TYR A  43
TYR A 275
 None
 1.46A 5igyA-4wj0A:
undetectable		 5igyA-4wj0A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 TYR A 201
ASP A 182
ILE A 196
TYR A 227
 None
 1.31A 5igyA-4yv7A:
undetectable		 5igyA-4yv7A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zc0 REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		4 ASP A 371
ILE A 441
ARG A 366
TYR A 389
 None
 1.06A 5igyA-4zc0A:
undetectable		 5igyA-4zc0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT
NA+,K+-ATPASE BETA
SUBUNIT

(Squalus
acanthias;
Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase)
PF00287
(Na_K-ATPase) 		4 TYR A1023
ILE A 998
TYR A1001
TYR B  40
 None
None
None
CLR  B3001 ( 4.0A)
 1.02A 5igyA-5aw4A:
undetectable		 5igyA-5aw4A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT

(Azospira oryzae) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 TYR A 549
ILE A 500
ARG A 855
TYR A 756
 None
 1.23A 5igyA-5chcA:
undetectable		 5igyA-5chcA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flw EXO-BETA-1,3-GALACTA
NASE

(Bifidobacterium
bifidum) 		PF04616
(Glyco_hydro_43) 		4 TYR A 256
ILE A 193
TYR A 150
TYR A 169
 None
 1.33A 5igyA-5flwA:
undetectable		 5igyA-5flwA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2t TREHALOSE SYNTHASE

(Thermomonospora
curvata) 		no annotation 4 TYR A 392
ASP A 409
ILE A 360
TYR A  80
 None
 1.33A 5igyA-5h2tA:
2.8		 5igyA-5h2tA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6b PUTATIVE SECRETED
LIPASE

(Streptomyces
sp. W007) 		PF01674
(Lipase_2) 		4 TYR A 199
ASP A 223
ILE A 241
TYR A 210
 None
 1.48A 5igyA-5h6bA:
undetectable		 5igyA-5h6bA:
21.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II

(Escherichia
coli) 		PF01636
(APH) 		4 ASP A 200
ILE A 233
ARG A 237
TYR A 273
 None
 0.46A 5igyA-5iguA:
31.0		 5igyA-5iguA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkj ESTERASE E22

(uncultured
bacterium) 		PF00561
(Abhydrolase_1) 		4 ASP A 112
ILE A 109
TYR A  54
TYR A  81
 None
 1.47A 5igyA-5jkjA:
undetectable		 5igyA-5jkjA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		4 TYR A 533
ILE A 490
ARG A 527
TYR A 342
 None
 1.37A 5igyA-5jlcA:
undetectable		 5igyA-5jlcA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mso CARBOXYLIC ACID
REDUCTASE

(Mycobacterium
marinum) 		PF07993
(NAD_binding_4) 		4 TYR A1033
ASP A1000
TYR A1121
TYR A 952
 None
 1.37A 5igyA-5msoA:
undetectable		 5igyA-5msoA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd4 TUBULIN ALPHA CHAIN

(Bos taurus) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 TYR A 161
ASP A 120
ILE A 115
ARG A 156
 None
 1.36A 5igyA-5nd4A:
undetectable		 5igyA-5nd4A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tta PUTATIVE EXPORTED
PROTEIN

(Clostridioides
difficile) 		no annotation 4 TYR A 252
ILE A  69
TYR A 272
TYR A 108
 None
 1.48A 5igyA-5ttaA:
undetectable		 5igyA-5ttaA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es9 ACYL-COA
DEHYDROGENASE

(Paracoccus
denitrificans) 		no annotation 4 TYR A 381
ASP A 197
ARG A 324
TYR A 243
 None
 1.22A 5igyA-6es9A:
undetectable		 5igyA-6es9A:
undetectable