SIMILAR PATTERNS OF AMINO ACIDS FOR 5IGY_A_ERYA403_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0d XYLOSE ISOMERASE

(Geobacillus
stearothermophilus) 		PF01261
(AP_endonuc_2) 		5 ILE A 322
GLY A 326
ASN A 325
SER A  43
PHE A  42
 None
 1.17A 5igyA-1a0dA:
0.0		 5igyA-1a0dA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bh6 SUBTILISIN DY

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		5 HIS A  67
GLY A  65
HIS A 226
ALA A 228
SER A 190
 None
 1.05A 5igyA-1bh6A:
0.0		 5igyA-1bh6A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbi AK.1 SERINE PROTEASE

(Bacillus sp.
Ak1) 		PF00082
(Peptidase_S8) 		5 HIS A  75
GLY A  73
HIS A 231
ALA A 233
SER A 195
 None
 1.10A 5igyA-1dbiA:
0.0		 5igyA-1dbiA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dun DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Equine
infectious
anemia virus) 		PF00692
(dUTPase) 		5 ILE A  82
GLY A  68
PHE A  99
ALA A 100
ILE A  86
 None
 1.19A 5igyA-1dunA:
0.0		 5igyA-1dunA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee6 PECTATE LYASE

(Bacillus sp.
KSM-P15) 		PF03211
(Pectate_lyase) 		5 ILE A  57
GLY A  64
PHE A  17
SER A  97
ILE A  96
 None
 1.01A 5igyA-1ee6A:
0.0		 5igyA-1ee6A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1em8 DNA POLYMERASE III
CHI SUBUNIT
DNA POLYMERASE III
PSI SUBUNIT

(Escherichia
coli;
Escherichia
coli) 		PF04364
(DNA_pol3_chi)
PF03603
(DNA_III_psi) 		5 GLY A  77
GLU A  54
PHE A  64
ALA B  60
ILE A  41
 None
 1.21A 5igyA-1em8A:
0.0		 5igyA-1em8A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idj PECTIN LYASE A

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		5 ILE A 337
HIS A 247
GLY A   9
ASN A 336
PHE A 328
 None
 1.11A 5igyA-1idjA:
0.0		 5igyA-1idjA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1u TYROSYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00579
(tRNA-synt_1b) 		5 ILE A  33
GLY A 170
ASN A 193
GLU A  94
ILE A  41
 None
 1.18A 5igyA-1j1uA:
0.0		 5igyA-1j1uA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE

(Escherichia
coli) 		PF01791
(DeoC) 		5 ASN A 176
PHE A  76
ILE A 166
PHE A 165
MET A 185
 None
 1.23A 5igyA-1ktnA:
undetectable		 5igyA-1ktnA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnz SPO0B-ASSOCIATED
GTP-BINDING PROTEIN

(Bacillus
subtilis) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		5 ILE A 217
HIS A 221
GLY A 219
GLU A 274
ALA A 211
 None
 1.10A 5igyA-1lnzA:
undetectable		 5igyA-1lnzA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n10 POLLEN ALLERGEN PHL
P 1

(Phleum pratense) 		PF01357
(Pollen_allerg_1)
PF03330
(DPBB_1) 		5 HIS A1111
GLY A1110
GLU A1087
ALA A1128
ILE A1076
 None
 1.23A 5igyA-1n10A:
undetectable		 5igyA-1n10A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 ILE A1452
GLY A1457
GLU A1434
ALA A1494
ILE A1465
 None
 1.21A 5igyA-1ofeA:
undetectable		 5igyA-1ofeA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1okg POSSIBLE
3-MERCAPTOPYRUVATE
SULFURTRANSFERASE

(Leishmania
major) 		PF00581
(Rhodanese)
PF09122
(DUF1930) 		5 ILE A 177
GLY A 204
ALA A 180
ILE A 292
PHE A 288
 None
 1.17A 5igyA-1okgA:
undetectable		 5igyA-1okgA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ph5 TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT

(Sterkiella nova) 		PF02765
(POT1) 		5 ILE A 296
ASN A 295
PHE A 299
ALA A 116
ILE A 160
 None
 1.14A 5igyA-1ph5A:
undetectable		 5igyA-1ph5A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poc PHOSPHOLIPASE A2

(Apis mellifera) 		PF05826
(Phospholip_A2_2) 		5 ILE A   2
GLY A  12
ASN A  13
SER A  80
PHE A  82
 None
GEL  A 420 (-3.4A)
None
None
None
 1.21A 5igyA-1pocA:
undetectable		 5igyA-1pocA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN

(Wolinella
succinogenes;
Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
PF13085
(Fer2_3)
PF13183
(Fer4_8) 		5 ILE A 419
GLY A 421
GLU A  66
ALA A 413
ILE B 130
 None
None
None
FAD  A1656 ( 3.8A)
None
 1.18A 5igyA-1qlbA:
undetectable		 5igyA-1qlbA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkx CDP-GLUCOSE-4,6-DEHY
DRATASE

(Yersinia
pseudotuberculosis) 		PF16363
(GDP_Man_Dehyd) 		5 ASN A 129
ALA A  89
SER A  75
ILE A  76
PHE A  79
 None
NAD  A 360 (-3.3A)
None
None
None
 1.06A 5igyA-1rkxA:
undetectable		 5igyA-1rkxA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 ILE A 723
GLY A 720
ASN A 725
PHE A 304
SER A 312
 None
 1.08A 5igyA-1rrhA:
1.2		 5igyA-1rrhA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio sp.
PA-44) 		PF00082
(Peptidase_S8) 		5 HIS A  73
GLY A  71
HIS A 225
ALA A 227
SER A 189
 None
 1.09A 5igyA-1s2nA:
undetectable		 5igyA-1s2nA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukw ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 GLY A 159
GLU A 393
SER A 188
ILE A 187
PHE A 153
 None
None
FAD  A 420 (-3.0A)
FAD  A 420 ( 4.4A)
FAD  A 420 (-4.8A)
 1.15A 5igyA-1ukwA:
undetectable		 5igyA-1ukwA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE

(Neisseria
gonorrhoeae) 		PF01128
(IspD) 		5 ILE A 124
GLY A 128
HIS A  45
PHE A  42
ALA A   7
 None
 1.24A 5igyA-1vgwA:
undetectable		 5igyA-1vgwA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w18 LEVANSUCRASE

(Gluconacetobacter
diazotrophicus) 		PF02435
(Glyco_hydro_68) 		5 GLY A 453
ASN A 449
GLU A 495
ALA A 523
SER A 483
 None
 1.15A 5igyA-1w18A:
undetectable		 5igyA-1w18A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvc GLUCOSE-1-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Salmonella
enterica) 		PF00483
(NTP_transferase) 		5 GLY A 190
HIS A 145
GLU A 123
PHE A 144
ILE A  48
 None
 1.08A 5igyA-1wvcA:
undetectable		 5igyA-1wvcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xw8 UPF0271 PROTEIN YBGL

(Escherichia
coli) 		PF03746
(LamB_YcsF) 		5 HIS A 197
GLY A 198
ALA A 161
ILE A 240
MET A   1
 None
 1.09A 5igyA-1xw8A:
undetectable		 5igyA-1xw8A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2i MALATE DEHYDROGENASE

(Agrobacterium
tumefaciens) 		PF02615
(Ldh_2) 		5 ASN A 148
HIS A 125
PHE A 126
ALA A 276
PHE A 268
 None
NAD  A 700 (-3.6A)
NAD  A 700 (-4.5A)
None
None
 1.24A 5igyA-1z2iA:
undetectable		 5igyA-1z2iA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE

(Phanerochaete
chrysosporium) 		no annotation 5 ILE A  74
HIS A  20
ASN A 250
PHE A  87
ALA A 102
 None
 1.06A 5igyA-2cl2A:
0.5		 5igyA-2cl2A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE

(Mus musculus) 		PF00342
(PGI) 		5 GLY A 189
PHE A 206
ALA A 225
SER A 160
ILE A 157
 None
None
None
PO4  A1601 (-2.7A)
None
 1.24A 5igyA-2cxnA:
undetectable		 5igyA-2cxnA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Synechococcus
sp.) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ILE A 223
ASN A 138
ALA A 153
ILE A 276
MET A 272
 None
 0.97A 5igyA-2d2iA:
1.1		 5igyA-2d2iA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2daz INAD-LIKE PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 ILE A  58
GLY A  62
ASN A  59
GLU A  75
ILE A  79
 None
 1.19A 5igyA-2dazA:
undetectable		 5igyA-2dazA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq3 SERYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		5 ILE A 167
GLY A 390
GLU A 425
ALA A 177
ILE A 144
 None
 1.23A 5igyA-2dq3A:
undetectable		 5igyA-2dq3A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7g RHA04620, PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF02909
(TetR_C) 		5 ILE A 132
GLU A  72
PHE A  80
ALA A 139
SER A 113
 None
 1.14A 5igyA-2g7gA:
undetectable		 5igyA-2g7gA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ics ADENINE DEAMINASE

(Enterococcus
faecalis) 		PF01979
(Amidohydro_1) 		5 ILE A 189
GLY A 219
ALA A 235
SER A 268
ILE A 244
 None
 1.21A 5igyA-2icsA:
undetectable		 5igyA-2icsA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nya PERIPLASMIC NITRATE
REDUCTASE

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 GLY A 177
HIS A 184
GLU A 503
ALA A 181
ILE A 331
 MGD  A4001 (-3.6A)
None
None
None
None
 1.20A 5igyA-2nyaA:
undetectable		 5igyA-2nyaA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oga TRANSAMINASE

(Streptomyces
venezuelae) 		PF01041
(DegT_DnrJ_EryC1) 		5 GLY A 258
ASN A 257
HIS A 143
ALA A 168
SER A 350
 None
 1.14A 5igyA-2ogaA:
undetectable		 5igyA-2ogaA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph5 HOMOSPERMIDINE
SYNTHASE

(Legionella
pneumophila) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 ILE A 200
GLY A 365
ASN A 366
GLU A 419
ALA A 175
 None
 1.22A 5igyA-2ph5A:
0.5		 5igyA-2ph5A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlc DNA REPAIR PROTEIN
RADC HOMOLOG

(Chlorobaculum
tepidum) 		PF04002
(RadC) 		5 ILE A 111
HIS A  77
GLY A 113
HIS A 109
ALA A   8
 None
 1.21A 5igyA-2qlcA:
undetectable		 5igyA-2qlcA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00583
(Acetyltransf_1)
PF00696
(AA_kinase) 		5 ILE A  30
GLU A 107
PHE A  98
ALA A  63
SER A 127
 None
 1.17A 5igyA-2r98A:
undetectable		 5igyA-2r98A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrc HUMAN COMPLEMENT
FACTOR I

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00089
(Trypsin)
PF00530
(SRCR) 		5 ILE A 339
GLY A 348
PHE A 399
ALA A 361
ILE A 352
 None
 1.04A 5igyA-2xrcA:
undetectable		 5igyA-2xrcA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b20 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(NADP+)

(Synechococcus
elongatus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ILE A 223
ASN A 138
ALA A 153
ILE A 276
MET A 272
 None
 1.21A 5igyA-3b20A:
undetectable		 5igyA-3b20A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdk SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE SUBUNIT
A

(Bacillus
subtilis) 		PF01144
(CoA_trans) 		5 ILE A 186
GLY A 184
HIS A 214
SER A  40
ILE A  41
 None
 1.12A 5igyA-3cdkA:
undetectable		 5igyA-3cdkA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkn PREPROTEIN
TRANSLOCASE SUBUNIT
SECY

(Canis lupus) 		PF00344
(SecY) 		5 GLY A 401
PHE A 382
ALA A 226
ILE A 257
PHE A 330
 None
 1.21A 5igyA-3dknA:
undetectable		 5igyA-3dknA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3x TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY, PUTATIVE

(Sulfolobus
solfataricus) 		PF13463
(HTH_27) 		5 ILE A 135
GLY A 131
ASN A 133
PHE A  61
ILE A  17
 None
 1.15A 5igyA-3f3xA:
undetectable		 5igyA-3f3xA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj4 MUCONATE
CYCLOISOMERASE

(Pseudomonas
protegens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 276
GLY A 280
ASN A 279
ALA A 289
ILE A  89
 None
 1.15A 5igyA-3fj4A:
undetectable		 5igyA-3fj4A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk5 3-OXOACYL-SYNTHASE
III

(Xanthomonas
oryzae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ILE A 127
GLY A 129
ALA A 299
ILE A   8
MET A 192
 None
 1.18A 5igyA-3fk5A:
undetectable		 5igyA-3fk5A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Clostridium
acetobutylicum) 		PF00155
(Aminotran_1_2) 		5 GLY A 151
ALA A 212
SER A  96
ILE A  95
PHE A  98
 None
PO4  A 362 ( 4.0A)
None
None
None
 1.23A 5igyA-3ftbA:
1.0		 5igyA-3ftbA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hp0 PUTATIVE POLYKETIDE
BIOSYNTHESIS
ENOYL-COA HYDRATASE
HOMOLOG PKSH

(Bacillus
subtilis) 		PF00378
(ECH_1) 		5 GLY A 156
SER A 171
ILE A 170
PHE A 133
MET A 163
 None
 1.16A 5igyA-3hp0A:
undetectable		 5igyA-3hp0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe) 		PF08389
(Xpo1) 		5 ILE T 715
GLY T 717
GLU T 662
SER T 605
ILE T 606
 None
 1.02A 5igyA-3icqT:
undetectable		 5igyA-3icqT:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE

(Drosophila
melanogaster) 		PF00282
(Pyridoxal_deC) 		5 ILE A 144
GLU A 113
ALA A  91
SER A 108
ILE A 106
 None
 1.07A 5igyA-3k40A:
undetectable		 5igyA-3k40A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldu PUTATIVE METHYLASE

(Clostridioides
difficile) 		PF01170
(UPF0020)
PF02926
(THUMP) 		5 GLY A 363
ASN A 362
HIS A 163
ALA A 181
SER A   8
 None
 0.93A 5igyA-3lduA:
undetectable		 5igyA-3lduA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lga SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
abyssi) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		5 ILE A 154
GLY A 101
PHE A 190
ALA A 192
PHE A  96
 SAH  A 301 (-4.3A)
SAH  A 301 (-3.1A)
None
None
None
 1.23A 5igyA-3lgaA:
undetectable		 5igyA-3lgaA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lss SERYL-TRNA
SYNTHETASE

(Trypanosoma
brucei) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		5 ILE A 462
GLY A 200
GLU A 438
ALA A 208
ILE A 308
 None
 1.08A 5igyA-3lssA:
undetectable		 5igyA-3lssA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE

(Shewanella
frigidimarina) 		PF04952
(AstE_AspA) 		5 GLY A 175
GLU A 257
ALA A  41
SER A 196
ILE A 197
 UNL  A 373 ( 3.5A)
None
None
None
None
 1.18A 5igyA-3lwuA:
undetectable		 5igyA-3lwuA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbu GLUCOSE-6-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00342
(PGI) 		5 GLY A 186
PHE A 203
ALA A 222
SER A 158
ILE A 155
 None
 1.18A 5igyA-3nbuA:
undetectable		 5igyA-3nbuA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5m ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 GLY A 145
SER A 160
ILE A 159
PHE A 121
MET A 152
 None
 1.13A 5igyA-3p5mA:
undetectable		 5igyA-3p5mA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8a UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF13468
(Glyoxalase_3) 		5 ILE A  65
GLY A  63
GLU A 271
SER A 260
ILE A 261
 None
 1.23A 5igyA-3p8aA:
undetectable		 5igyA-3p8aA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3quf EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		PF13416
(SBP_bac_8) 		5 GLU A 262
PHE A 288
SER A 184
ILE A 179
MET A 175
 None
 1.09A 5igyA-3qufA:
undetectable		 5igyA-3qufA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rb5 NA/CA EXCHANGE
PROTEIN

(Drosophila
melanogaster) 		PF03160
(Calx-beta) 		5 ILE A 556
GLY A 683
ASN A 682
HIS A 553
GLU A 521
 None
 1.22A 5igyA-3rb5A:
undetectable		 5igyA-3rb5A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry7 RIBOKINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		5 ILE A  72
GLY A  40
ASN A  12
ALA A 115
ILE A   7
 None
GOL  A 401 ( 3.7A)
GOL  A 401 (-3.9A)
None
None
 1.22A 5igyA-3ry7A:
undetectable		 5igyA-3ry7A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sg1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Bacillus
anthracis) 		PF00275
(EPSP_synthase) 		5 ILE A 251
GLY A  14
ASN A  13
ILE A 414
PHE A 403
 None
 1.23A 5igyA-3sg1A:
undetectable		 5igyA-3sg1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbm COPPER-CONTAINING
NITRITE REDUCTASE

(Ralstonia
pickettii) 		PF07732
(Cu-oxidase_3)
PF13442
(Cytochrome_CBB3) 		5 GLY A 269
ALA A 136
SER A  70
PHE A  71
MET A 170
 None
 1.10A 5igyA-3zbmA:
undetectable		 5igyA-3zbmA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zt9 SERINE PHOSPHATASE

(Moorella
thermoacetica) 		PF07228
(SpoIIE) 		5 ILE A 147
GLY A  37
ALA A 119
ILE A  68
MET A  57
 None
 1.21A 5igyA-3zt9A:
undetectable		 5igyA-3zt9A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C

(Homo sapiens) 		PF00560
(LRR_1)
PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 GLY A 180
GLU A 194
PHE A 144
SER A 189
ILE A 188
 None
 1.18A 5igyA-3zyjA:
undetectable		 5igyA-3zyjA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aef NEOPULLULANASE
(ALPHA-AMYLASE II)

(Pyrococcus
furiosus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16561
(AMPK1_CBM) 		5 ILE A 538
PHE A 217
ALA A 218
SER A 550
ILE A 543
 None
 1.16A 5igyA-4aefA:
undetectable		 5igyA-4aefA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apb FUMARATE HYDRATASE
CLASS II

(Mycobacterium
tuberculosis) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 HIS A 148
ASN A 359
ALA A 352
SER A 372
PHE A 373
 None
 1.24A 5igyA-4apbA:
undetectable		 5igyA-4apbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Escherichia
coli) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 ILE A 336
GLY A 339
ASN A 338
HIS A 333
GLU A 354
 None
 1.19A 5igyA-4bhtA:
undetectable		 5igyA-4bhtA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwq TRNA-SPLICING LIGASE
RTCB

(Pyrococcus
horikoshii) 		PF01139
(RtcB) 		5 ILE A  92
ASN A 330
HIS A 349
ALA A 353
MET A 175
 None
MLI  A 503 (-4.1A)
None
None
None
 1.22A 5igyA-4dwqA:
undetectable		 5igyA-4dwqA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwb HALOALKANE
DEHALOGENASE

(Rhodococcus
rhodochrous) 		PF00561
(Abhydrolase_1) 		5 HIS A 272
GLU A 276
PHE A 245
ALA A 145
ILE A 169
 CL  A2003 ( 3.7A)
None
CL  A2003 ( 4.7A)
None
None
 1.25A 5igyA-4fwbA:
undetectable		 5igyA-4fwbA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF

(Thermococcus
kodakarensis) 		PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		5 ILE A 538
GLY A 521
GLU A 652
PHE A 666
ALA A 617
 None
 1.21A 5igyA-4g9iA:
undetectable		 5igyA-4g9iA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqa NAD BINDING
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ILE A 262
GLY A 160
ALA A 258
ILE A 135
PHE A 132
 None
 1.17A 5igyA-4gqaA:
1.5		 5igyA-4gqaA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Acinetobacter
sp. ADP1) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 ILE A 344
GLY A 347
GLU A 248
ALA A 124
PHE A 111
 None
 1.10A 5igyA-4gtnA:
undetectable		 5igyA-4gtnA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imd N-ACETYLNEURAMINATE
LYASE

(Pasteurella
multocida) 		PF00701
(DHDPS) 		5 ILE A 146
ASN A 145
PHE A 165
ALA A 167
SER A 104
 None
 1.18A 5igyA-4imdA:
undetectable		 5igyA-4imdA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyj GDSL-LIKE PROTEIN

(Bacteroides
uniformis) 		PF13472
(Lipase_GDSL_2) 		5 GLY A  52
ASN A  53
GLU A 120
ALA A 111
ILE A 171
 None
UNL  A 301 ( 2.5A)
None
None
None
 1.10A 5igyA-4iyjA:
undetectable		 5igyA-4iyjA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwj TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01746
(tRNA_m1G_MT) 		5 GLY A 206
GLU A 149
ALA A 122
ILE A 112
MET A 107
 SAH  A 302 (-3.1A)
None
None
None
None
 1.01A 5igyA-4jwjA:
undetectable		 5igyA-4jwjA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lx4 ENDOGLUCANASE(ENDO-1
,4-BETA-GLUCANASE)PR
OTEIN

(Pseudomonas
stutzeri) 		PF00150
(Cellulase) 		5 GLY A  51
GLU A 252
ALA A  87
ILE A 296
MET A 307
 None
TRS  A 401 (-2.6A)
None
None
None
 1.17A 5igyA-4lx4A:
undetectable		 5igyA-4lx4A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu EDS1

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		5 ILE A 142
GLY A 510
ASN A 509
GLU A 447
ILE A  77
 None
None
None
BGC  A 701 ( 4.5A)
None
 1.15A 5igyA-4nfuA:
undetectable		 5igyA-4nfuA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng4 PHOSPHOGLYCERATE
KINASE

(Coxiella
burnetii) 		PF00162
(PGK) 		5 ILE A 318
GLY A 193
PHE A 358
ALA A 354
ILE A 312
 None
 0.95A 5igyA-4ng4A:
undetectable		 5igyA-4ng4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi6 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		5 ILE A 740
ASN A 706
GLU A 758
ALA A 480
ILE A 764
 None
None
None
FAD  A 902 (-3.9A)
None
 1.24A 5igyA-4qi6A:
1.5		 5igyA-4qi6A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyj ALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 ILE A 356
GLY A 369
GLU A 400
ALA A 364
ILE A 293
 None
 0.91A 5igyA-4qyjA:
undetectable		 5igyA-4qyjA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase) 		5 ILE A 922
GLY A 924
ASN A 902
GLU A 623
SER A 651
 None
 1.09A 5igyA-4ra7A:
undetectable		 5igyA-4ra7A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzu ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 GLY A 192
ASN A 193
ALA A 182
SER A 131
ILE A 130
 None
None
CL  A1487 (-3.8A)
None
None
 1.23A 5igyA-4uzuA:
2.2		 5igyA-4uzuA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkm XYLOSE ISOMERASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 ILE A 327
GLY A 332
ASN A 330
ALA A 288
PHE A 340
 None
 1.11A 5igyA-4xkmA:
undetectable		 5igyA-4xkmA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN

(Bordetella
bronchiseptica) 		PF03480
(DctP) 		5 GLY A 105
GLU A 140
PHE A 112
ILE A 147
MET A  85
 None
 1.13A 5igyA-4yzzA:
undetectable		 5igyA-4yzzA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnn CAPSID PROTEIN VP2

(Enterovirus D) 		PF00073
(Rhv) 		5 ILE B 108
GLU B 150
PHE B  63
SER B  68
ILE B 228
 None
 1.20A 5igyA-5bnnB:
undetectable		 5igyA-5bnnB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5y DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Colwellia
psychrerythraea) 		PF01791
(DeoC) 		5 ASN A 175
PHE A  76
ILE A 165
PHE A 164
MET A 184
 None
 1.23A 5igyA-5c5yA:
undetectable		 5igyA-5c5yA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5y DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Colwellia
psychrerythraea) 		PF01791
(DeoC) 		5 ILE A 165
GLY A 196
GLU A 147
ALA A 200
ILE A 219
 None
None
None
UNL  A 301 ( 4.2A)
None
 1.04A 5igyA-5c5yA:
undetectable		 5igyA-5c5yA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Cryptococcus
neoformans) 		PF02358
(Trehalose_PPase) 		5 ILE A 205
GLY A 267
GLU A 190
PHE A 218
ALA A 282
 None
 0.98A 5igyA-5dx9A:
undetectable		 5igyA-5dx9A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03552
(Cellulose_synt)
PF07238
(PilZ) 		5 GLY A 308
ALA A 405
SER A 113
ILE A 114
PHE A 115
 None
None
None
BGC  A 914 ( 4.7A)
BGC  A 913 ( 4.7A)
 1.16A 5igyA-5ej1A:
0.0		 5igyA-5ej1A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby SEPARASE

(Chaetomium
thermophilum) 		PF03568
(Peptidase_C50) 		5 ILE A1884
HIS A1830
GLY A1887
GLU A1835
ALA A1935
 None
 1.12A 5igyA-5fbyA:
undetectable		 5igyA-5fbyA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5goo ALKALINE INVERTASE

(Nostoc sp. PCC
7120) 		PF12899
(Glyco_hydro_100) 		5 GLY A 438
ALA A 396
SER A 456
ILE A 455
PHE A 454
 None
 1.01A 5igyA-5gooA:
undetectable		 5igyA-5gooA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		5 ILE A 406
GLY A 385
HIS A  47
GLU A 417
ILE A 358
 None
 0.86A 5igyA-5gslA:
undetectable		 5igyA-5gslA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 HIS A 106
GLY A 190
ASN A 192
ALA A 263
SER A  79
 None
 1.13A 5igyA-5hc4A:
undetectable		 5igyA-5hc4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hoe HYDROLASE

(Sinorhizobium
meliloti) 		PF13472
(Lipase_GDSL_2) 		5 ILE A 188
GLY A 185
ALA A 145
SER A  13
MET A  92
 None
None
None
PO4  A 301 (-2.5A)
None
 1.15A 5igyA-5hoeA:
undetectable		 5igyA-5hoeA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j2y REGULATORY PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 5 GLY A  47
ASN A  46
SER A  32
ILE A  36
PHE A  34
 None
 1.15A 5igyA-5j2yA:
undetectable		 5igyA-5j2yA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m11 IMMUNOREACTIVE 84KD
ANTIGEN PG93

(Porphyromonas
gingivalis) 		no annotation 5 GLY A 673
ASN A 332
ALA A  54
SER A  76
ILE A  75
 None
 1.18A 5igyA-5m11A:
undetectable		 5igyA-5m11A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzb D-AMINOPEPTIDASE

(Burkholderia
sp. LK4) 		PF03576
(Peptidase_S58) 		5 ILE A 329
GLY A 179
ASN A 331
ILE A 244
PHE A 281
 None
 1.14A 5igyA-5tzbA:
undetectable		 5igyA-5tzbA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z2g L-AMINO ACID OXIDASE

(Naja atra) 		no annotation 5 GLY A 480
PHE A  30
ALA A 244
ILE A 116
PHE A  38
 FAD  A 604 (-4.0A)
None
None
None
None
 1.14A 5igyA-5z2gA:
undetectable		 5igyA-5z2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 ILE H 319
GLY H 287
ASN H 286
GLU H 310
PHE H 282
 None
 0.98A 5igyA-6chsH:
undetectable		 5igyA-6chsH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmz DIHYDROLIPOYL
DEHYDROGENASE

(Burkholderia
cenocepacia) 		no annotation 5 ILE A 354
GLY A 412
ALA A 419
SER A  51
ILE A  55
 None
None
None
FAD  A 502 (-3.6A)
None
 1.01A 5igyA-6cmzA:
undetectable		 5igyA-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elq CARBON MONOXIDE
DEHYDROGENASE

(Carboxydothermus
hydrogenoformans) 		no annotation 5 GLY X 523
ASN X 298
HIS X  95
SER X 565
ILE X 566
 None
 1.16A 5igyA-6elqX:
undetectable		 5igyA-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6erc PEROXINECTIN A

(Dictyostelium
discoideum) 		no annotation 5 ILE A 170
GLY A 172
ASN A 173
ALA A 104
ILE A 243
 None
None
NA  A 609 (-3.3A)
HEM  A 604 ( 3.9A)
None
 1.24A 5igyA-6ercA:
undetectable		 5igyA-6ercA:
undetectable