SIMILAR PATTERNS OF AMINO ACIDS FOR 5IGY_A_ERYA403

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0d XYLOSE ISOMERASE

(Geobacillus
stearothermophilus) 		PF01261
(AP_endonuc_2) 		5 ILE A 322
GLY A 326
ASN A 325
SER A  43
PHE A  42
 None
 1.17A 5igyA-1a0dA:
0.0		 5igyA-1a0dA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bh6 SUBTILISIN DY

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		5 HIS A  67
GLY A  65
HIS A 226
ALA A 228
SER A 190
 None
 1.05A 5igyA-1bh6A:
0.0		 5igyA-1bh6A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbi AK.1 SERINE PROTEASE

(Bacillus sp.
Ak1) 		PF00082
(Peptidase_S8) 		5 HIS A  75
GLY A  73
HIS A 231
ALA A 233
SER A 195
 None
 1.10A 5igyA-1dbiA:
0.0		 5igyA-1dbiA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dun DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Equine
infectious
anemia virus) 		PF00692
(dUTPase) 		5 ILE A  82
GLY A  68
PHE A  99
ALA A 100
ILE A  86
 None
 1.19A 5igyA-1dunA:
0.0		 5igyA-1dunA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee6 PECTATE LYASE

(Bacillus sp.
KSM-P15) 		PF03211
(Pectate_lyase) 		5 ILE A  57
GLY A  64
PHE A  17
SER A  97
ILE A  96
 None
 1.01A 5igyA-1ee6A:
0.0		 5igyA-1ee6A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1em8 DNA POLYMERASE III
CHI SUBUNIT
DNA POLYMERASE III
PSI SUBUNIT

(Escherichia
coli;
Escherichia
coli) 		PF04364
(DNA_pol3_chi)
PF03603
(DNA_III_psi) 		5 GLY A  77
GLU A  54
PHE A  64
ALA B  60
ILE A  41
 None
 1.21A 5igyA-1em8A:
0.0		 5igyA-1em8A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idj PECTIN LYASE A

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		5 ILE A 337
HIS A 247
GLY A   9
ASN A 336
PHE A 328
 None
 1.11A 5igyA-1idjA:
0.0		 5igyA-1idjA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1u TYROSYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00579
(tRNA-synt_1b) 		5 ILE A  33
GLY A 170
ASN A 193
GLU A  94
ILE A  41
 None
 1.18A 5igyA-1j1uA:
0.0		 5igyA-1j1uA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE

(Escherichia
coli) 		PF01791
(DeoC) 		5 ASN A 176
PHE A  76
ILE A 166
PHE A 165
MET A 185
 None
 1.23A 5igyA-1ktnA:
undetectable		 5igyA-1ktnA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnz SPO0B-ASSOCIATED
GTP-BINDING PROTEIN

(Bacillus
subtilis) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		5 ILE A 217
HIS A 221
GLY A 219
GLU A 274
ALA A 211
 None
 1.10A 5igyA-1lnzA:
undetectable		 5igyA-1lnzA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n10 POLLEN ALLERGEN PHL
P 1

(Phleum pratense) 		PF01357
(Pollen_allerg_1)
PF03330
(DPBB_1) 		5 HIS A1111
GLY A1110
GLU A1087
ALA A1128
ILE A1076
 None
 1.23A 5igyA-1n10A:
undetectable		 5igyA-1n10A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 ILE A1452
GLY A1457
GLU A1434
ALA A1494
ILE A1465
 None
 1.21A 5igyA-1ofeA:
undetectable		 5igyA-1ofeA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1okg POSSIBLE
3-MERCAPTOPYRUVATE
SULFURTRANSFERASE

(Leishmania
major) 		PF00581
(Rhodanese)
PF09122
(DUF1930) 		5 ILE A 177
GLY A 204
ALA A 180
ILE A 292
PHE A 288
 None
 1.17A 5igyA-1okgA:
undetectable		 5igyA-1okgA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ph5 TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT

(Sterkiella nova) 		PF02765
(POT1) 		5 ILE A 296
ASN A 295
PHE A 299
ALA A 116
ILE A 160
 None
 1.14A 5igyA-1ph5A:
undetectable		 5igyA-1ph5A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poc PHOSPHOLIPASE A2

(Apis mellifera) 		PF05826
(Phospholip_A2_2) 		5 ILE A   2
GLY A  12
ASN A  13
SER A  80
PHE A  82
 None
GEL  A 420 (-3.4A)
None
None
None
 1.21A 5igyA-1pocA:
undetectable		 5igyA-1pocA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN

(Wolinella
succinogenes;
Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
PF13085
(Fer2_3)
PF13183
(Fer4_8) 		5 ILE A 419
GLY A 421
GLU A  66
ALA A 413
ILE B 130
 None
None
None
FAD  A1656 ( 3.8A)
None
 1.18A 5igyA-1qlbA:
undetectable		 5igyA-1qlbA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkx CDP-GLUCOSE-4,6-DEHY
DRATASE

(Yersinia
pseudotuberculosis) 		PF16363
(GDP_Man_Dehyd) 		5 ASN A 129
ALA A  89
SER A  75
ILE A  76
PHE A  79
 None
NAD  A 360 (-3.3A)
None
None
None
 1.06A 5igyA-1rkxA:
undetectable		 5igyA-1rkxA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 ILE A 723
GLY A 720
ASN A 725
PHE A 304
SER A 312
 None
 1.08A 5igyA-1rrhA:
1.2		 5igyA-1rrhA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio sp.
PA-44) 		PF00082
(Peptidase_S8) 		5 HIS A  73
GLY A  71
HIS A 225
ALA A 227
SER A 189
 None
 1.09A 5igyA-1s2nA:
undetectable		 5igyA-1s2nA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukw ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 GLY A 159
GLU A 393
SER A 188
ILE A 187
PHE A 153
 None
None
FAD  A 420 (-3.0A)
FAD  A 420 ( 4.4A)
FAD  A 420 (-4.8A)
 1.15A 5igyA-1ukwA:
undetectable		 5igyA-1ukwA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE

(Neisseria
gonorrhoeae) 		PF01128
(IspD) 		5 ILE A 124
GLY A 128
HIS A  45
PHE A  42
ALA A   7
 None
 1.24A 5igyA-1vgwA:
undetectable		 5igyA-1vgwA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w18 LEVANSUCRASE

(Gluconacetobacter
diazotrophicus) 		PF02435
(Glyco_hydro_68) 		5 GLY A 453
ASN A 449
GLU A 495
ALA A 523
SER A 483
 None
 1.15A 5igyA-1w18A:
undetectable		 5igyA-1w18A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvc GLUCOSE-1-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Salmonella
enterica) 		PF00483
(NTP_transferase) 		5 GLY A 190
HIS A 145
GLU A 123
PHE A 144
ILE A  48
 None
 1.08A 5igyA-1wvcA:
undetectable		 5igyA-1wvcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xw8 UPF0271 PROTEIN YBGL

(Escherichia
coli) 		PF03746
(LamB_YcsF) 		5 HIS A 197
GLY A 198
ALA A 161
ILE A 240
MET A   1
 None
 1.09A 5igyA-1xw8A:
undetectable		 5igyA-1xw8A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2i MALATE DEHYDROGENASE

(Agrobacterium
tumefaciens) 		PF02615
(Ldh_2) 		5 ASN A 148
HIS A 125
PHE A 126
ALA A 276
PHE A 268
 None
NAD  A 700 (-3.6A)
NAD  A 700 (-4.5A)
None
None
 1.24A 5igyA-1z2iA:
undetectable		 5igyA-1z2iA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE

(Phanerochaete
chrysosporium) 		no annotation 5 ILE A  74
HIS A  20
ASN A 250
PHE A  87
ALA A 102
 None
 1.06A 5igyA-2cl2A:
0.5		 5igyA-2cl2A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE

(Mus musculus) 		PF00342
(PGI) 		5 GLY A 189
PHE A 206
ALA A 225
SER A 160
ILE A 157
 None
None
None
PO4  A1601 (-2.7A)
None
 1.24A 5igyA-2cxnA:
undetectable		 5igyA-2cxnA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Synechococcus
sp.) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ILE A 223
ASN A 138
ALA A 153
ILE A 276
MET A 272
 None
 0.97A 5igyA-2d2iA:
1.1		 5igyA-2d2iA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2daz INAD-LIKE PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 ILE A  58
GLY A  62
ASN A  59
GLU A  75
ILE A  79
 None
 1.19A 5igyA-2dazA:
undetectable		 5igyA-2dazA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq3 SERYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		5 ILE A 167
GLY A 390
GLU A 425
ALA A 177
ILE A 144
 None
 1.23A 5igyA-2dq3A:
undetectable		 5igyA-2dq3A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7g RHA04620, PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF02909
(TetR_C) 		5 ILE A 132
GLU A  72
PHE A  80
ALA A 139
SER A 113
 None
 1.14A 5igyA-2g7gA:
undetectable		 5igyA-2g7gA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ics ADENINE DEAMINASE

(Enterococcus
faecalis) 		PF01979
(Amidohydro_1) 		5 ILE A 189
GLY A 219
ALA A 235
SER A 268
ILE A 244
 None
 1.21A 5igyA-2icsA:
undetectable		 5igyA-2icsA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nya PERIPLASMIC NITRATE
REDUCTASE

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 GLY A 177
HIS A 184
GLU A 503
ALA A 181
ILE A 331
 MGD  A4001 (-3.6A)
None
None
None
None
 1.20A 5igyA-2nyaA:
undetectable		 5igyA-2nyaA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oga TRANSAMINASE

(Streptomyces
venezuelae) 		PF01041
(DegT_DnrJ_EryC1) 		5 GLY A 258
ASN A 257
HIS A 143
ALA A 168
SER A 350
 None
 1.14A 5igyA-2ogaA:
undetectable		 5igyA-2ogaA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph5 HOMOSPERMIDINE
SYNTHASE

(Legionella
pneumophila) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 ILE A 200
GLY A 365
ASN A 366
GLU A 419
ALA A 175
 None
 1.22A 5igyA-2ph5A:
0.5		 5igyA-2ph5A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlc DNA REPAIR PROTEIN
RADC HOMOLOG

(Chlorobaculum
tepidum) 		PF04002
(RadC) 		5 ILE A 111
HIS A  77
GLY A 113
HIS A 109
ALA A   8
 None
 1.21A 5igyA-2qlcA:
undetectable		 5igyA-2qlcA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00583
(Acetyltransf_1)
PF00696
(AA_kinase) 		5 ILE A  30
GLU A 107
PHE A  98
ALA A  63
SER A 127
 None
 1.17A 5igyA-2r98A:
undetectable		 5igyA-2r98A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrc HUMAN COMPLEMENT
FACTOR I

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00089
(Trypsin)
PF00530
(SRCR) 		5 ILE A 339
GLY A 348
PHE A 399
ALA A 361
ILE A 352
 None
 1.04A 5igyA-2xrcA:
undetectable		 5igyA-2xrcA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b20 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(NADP+)

(Synechococcus
elongatus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ILE A 223
ASN A 138
ALA A 153
ILE A 276
MET A 272
 None
 1.21A 5igyA-3b20A:
undetectable		 5igyA-3b20A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdk SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE SUBUNIT
A

(Bacillus
subtilis) 		PF01144
(CoA_trans) 		5 ILE A 186
GLY A 184
HIS A 214
SER A  40
ILE A  41
 None
 1.12A 5igyA-3cdkA:
undetectable		 5igyA-3cdkA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkn PREPROTEIN
TRANSLOCASE SUBUNIT
SECY

(Canis lupus) 		PF00344
(SecY) 		5 GLY A 401
PHE A 382
ALA A 226
ILE A 257
PHE A 330
 None
 1.21A 5igyA-3dknA:
undetectable		 5igyA-3dknA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3x TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY, PUTATIVE

(Sulfolobus
solfataricus) 		PF13463
(HTH_27) 		5 ILE A 135
GLY A 131
ASN A 133
PHE A  61
ILE A  17
 None
 1.15A 5igyA-3f3xA:
undetectable		 5igyA-3f3xA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj4 MUCONATE
CYCLOISOMERASE

(Pseudomonas
protegens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 276
GLY A 280
ASN A 279
ALA A 289
ILE A  89
 None
 1.15A 5igyA-3fj4A:
undetectable		 5igyA-3fj4A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk5 3-OXOACYL-SYNTHASE
III

(Xanthomonas
oryzae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ILE A 127
GLY A 129
ALA A 299
ILE A   8
MET A 192
 None
 1.18A 5igyA-3fk5A:
undetectable		 5igyA-3fk5A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Clostridium
acetobutylicum) 		PF00155
(Aminotran_1_2) 		5 GLY A 151
ALA A 212
SER A  96
ILE A  95
PHE A  98
 None
PO4  A 362 ( 4.0A)
None
None
None
 1.23A 5igyA-3ftbA:
1.0		 5igyA-3ftbA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hp0 PUTATIVE POLYKETIDE
BIOSYNTHESIS
ENOYL-COA HYDRATASE
HOMOLOG PKSH

(Bacillus
subtilis) 		PF00378
(ECH_1) 		5 GLY A 156
SER A 171
ILE A 170
PHE A 133
MET A 163
 None
 1.16A 5igyA-3hp0A:
undetectable		 5igyA-3hp0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe) 		PF08389
(Xpo1) 		5 ILE T 715
GLY T 717
GLU T 662
SER T 605
ILE T 606
 None
 1.02A 5igyA-3icqT:
undetectable		 5igyA-3icqT:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE

(Drosophila
melanogaster) 		PF00282
(Pyridoxal_deC) 		5 ILE A 144
GLU A 113
ALA A  91
SER A 108
ILE A 106
 None
 1.07A 5igyA-3k40A:
undetectable		 5igyA-3k40A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldu PUTATIVE METHYLASE

(Clostridioides
difficile) 		PF01170
(UPF0020)
PF02926
(THUMP) 		5 GLY A 363
ASN A 362
HIS A 163
ALA A 181
SER A   8
 None
 0.93A 5igyA-3lduA:
undetectable		 5igyA-3lduA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lga SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
abyssi) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		5 ILE A 154
GLY A 101
PHE A 190
ALA A 192
PHE A  96
 SAH  A 301 (-4.3A)
SAH  A 301 (-3.1A)
None
None
None
 1.23A 5igyA-3lgaA:
undetectable		 5igyA-3lgaA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lss SERYL-TRNA
SYNTHETASE

(Trypanosoma
brucei) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		5 ILE A 462
GLY A 200
GLU A 438
ALA A 208
ILE A 308
 None
 1.08A 5igyA-3lssA:
undetectable		 5igyA-3lssA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE

(Shewanella
frigidimarina) 		PF04952
(AstE_AspA) 		5 GLY A 175
GLU A 257
ALA A  41
SER A 196
ILE A 197
 UNL  A 373 ( 3.5A)
None
None
None
None
 1.18A 5igyA-3lwuA:
undetectable		 5igyA-3lwuA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbu GLUCOSE-6-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00342
(PGI) 		5 GLY A 186
PHE A 203
ALA A 222
SER A 158
ILE A 155
 None
 1.18A 5igyA-3nbuA:
undetectable		 5igyA-3nbuA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5m ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 GLY A 145
SER A 160
ILE A 159
PHE A 121
MET A 152
 None
 1.13A 5igyA-3p5mA:
undetectable		 5igyA-3p5mA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8a UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF13468
(Glyoxalase_3) 		5 ILE A  65
GLY A  63
GLU A 271
SER A 260
ILE A 261
 None
 1.23A 5igyA-3p8aA:
undetectable		 5igyA-3p8aA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3quf EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		PF13416
(SBP_bac_8) 		5 GLU A 262
PHE A 288
SER A 184
ILE A 179
MET A 175
 None
 1.09A 5igyA-3qufA:
undetectable		 5igyA-3qufA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rb5 NA/CA EXCHANGE
PROTEIN

(Drosophila
melanogaster) 		PF03160
(Calx-beta) 		5 ILE A 556
GLY A 683
ASN A 682
HIS A 553
GLU A 521
 None
 1.22A 5igyA-3rb5A:
undetectable		 5igyA-3rb5A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry7 RIBOKINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		5 ILE A  72
GLY A  40
ASN A  12
ALA A 115
ILE A   7
 None
GOL  A 401 ( 3.7A)
GOL  A 401 (-3.9A)
None
None
 1.22A 5igyA-3ry7A:
undetectable		 5igyA-3ry7A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sg1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Bacillus
anthracis) 		PF00275
(EPSP_synthase) 		5 ILE A 251
GLY A  14
ASN A  13
ILE A 414
PHE A 403
 None
 1.23A 5igyA-3sg1A:
undetectable		 5igyA-3sg1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbm COPPER-CONTAINING
NITRITE REDUCTASE

(Ralstonia
pickettii) 		PF07732
(Cu-oxidase_3)
PF13442
(Cytochrome_CBB3) 		5 GLY A 269
ALA A 136
SER A  70
PHE A  71
MET A 170
 None
 1.10A 5igyA-3zbmA:
undetectable		 5igyA-3zbmA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zt9 SERINE PHOSPHATASE

(Moorella
thermoacetica) 		PF07228
(SpoIIE) 		5 ILE A 147
GLY A  37
ALA A 119
ILE A  68
MET A  57
 None
 1.21A 5igyA-3zt9A:
undetectable		 5igyA-3zt9A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C

(Homo sapiens) 		PF00560
(LRR_1)
PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 GLY A 180
GLU A 194
PHE A 144
SER A 189
ILE A 188
 None
 1.18A 5igyA-3zyjA:
undetectable		 5igyA-3zyjA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aef NEOPULLULANASE
(ALPHA-AMYLASE II)

(Pyrococcus
furiosus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16561
(AMPK1_CBM) 		5 ILE A 538
PHE A 217
ALA A 218
SER A 550
ILE A 543
 None
 1.16A 5igyA-4aefA:
undetectable		 5igyA-4aefA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apb FUMARATE HYDRATASE
CLASS II

(Mycobacterium
tuberculosis) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 HIS A 148
ASN A 359
ALA A 352
SER A 372
PHE A 373
 None
 1.24A 5igyA-4apbA:
undetectable		 5igyA-4apbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Escherichia
coli) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 ILE A 336
GLY A 339
ASN A 338
HIS A 333
GLU A 354
 None
 1.19A 5igyA-4bhtA:
undetectable		 5igyA-4bhtA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwq TRNA-SPLICING LIGASE
RTCB

(Pyrococcus
horikoshii) 		PF01139
(RtcB) 		5 ILE A  92
ASN A 330
HIS A 349
ALA A 353
MET A 175
 None
MLI  A 503 (-4.1A)
None
None
None
 1.22A 5igyA-4dwqA:
undetectable		 5igyA-4dwqA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwb HALOALKANE
DEHALOGENASE

(Rhodococcus
rhodochrous) 		PF00561
(Abhydrolase_1) 		5 HIS A 272
GLU A 276
PHE A 245
ALA A 145
ILE A 169
 CL  A2003 ( 3.7A)
None
CL  A2003 ( 4.7A)
None
None
 1.25A 5igyA-4fwbA:
undetectable		 5igyA-4fwbA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF

(Thermococcus
kodakarensis) 		PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		5 ILE A 538
GLY A 521
GLU A 652
PHE A 666
ALA A 617
 None
 1.21A 5igyA-4g9iA:
undetectable		 5igyA-4g9iA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqa NAD BINDING
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ILE A 262
GLY A 160
ALA A 258
ILE A 135
PHE A 132
 None
 1.17A 5igyA-4gqaA:
1.5		 5igyA-4gqaA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Acinetobacter
sp. ADP1) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 ILE A 344
GLY A 347
GLU A 248
ALA A 124
PHE A 111
 None
 1.10A 5igyA-4gtnA:
undetectable		 5igyA-4gtnA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imd N-ACETYLNEURAMINATE
LYASE

(Pasteurella
multocida) 		PF00701
(DHDPS) 		5 ILE A 146
ASN A 145
PHE A 165
ALA A 167
SER A 104
 None
 1.18A 5igyA-4imdA:
undetectable		 5igyA-4imdA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyj GDSL-LIKE PROTEIN

(Bacteroides
uniformis) 		PF13472
(Lipase_GDSL_2) 		5 GLY A  52
ASN A  53
GLU A 120
ALA A 111
ILE A 171
 None
UNL  A 301 ( 2.5A)
None
None
None
 1.10A 5igyA-4iyjA:
undetectable		 5igyA-4iyjA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwj TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01746
(tRNA_m1G_MT) 		5 GLY A 206
GLU A 149
ALA A 122
ILE A 112
MET A 107
 SAH  A 302 (-3.1A)
None
None
None
None
 1.01A 5igyA-4jwjA:
undetectable		 5igyA-4jwjA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lx4 ENDOGLUCANASE(ENDO-1
,4-BETA-GLUCANASE)PR
OTEIN

(Pseudomonas
stutzeri) 		PF00150
(Cellulase) 		5 GLY A  51
GLU A 252
ALA A  87
ILE A 296
MET A 307
 None
TRS  A 401 (-2.6A)
None
None
None
 1.17A 5igyA-4lx4A:
undetectable		 5igyA-4lx4A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu EDS1

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		5 ILE A 142
GLY A 510
ASN A 509
GLU A 447
ILE A  77
 None
None
None
BGC  A 701 ( 4.5A)
None
 1.15A 5igyA-4nfuA:
undetectable		 5igyA-4nfuA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng4 PHOSPHOGLYCERATE
KINASE

(Coxiella
burnetii) 		PF00162
(PGK) 		5 ILE A 318
GLY A 193
PHE A 358
ALA A 354
ILE A 312
 None
 0.95A 5igyA-4ng4A:
undetectable		 5igyA-4ng4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi6 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		5 ILE A 740
ASN A 706
GLU A 758
ALA A 480
ILE A 764
 None
None
None
FAD  A 902 (-3.9A)
None
 1.24A 5igyA-4qi6A:
1.5		 5igyA-4qi6A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyj ALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 ILE A 356
GLY A 369
GLU A 400
ALA A 364
ILE A 293
 None
 0.91A 5igyA-4qyjA:
undetectable		 5igyA-4qyjA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase) 		5 ILE A 922
GLY A 924
ASN A 902
GLU A 623
SER A 651
 None
 1.09A 5igyA-4ra7A:
undetectable		 5igyA-4ra7A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzu ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 GLY A 192
ASN A 193
ALA A 182
SER A 131
ILE A 130
 None
None
CL  A1487 (-3.8A)
None
None
 1.23A 5igyA-4uzuA:
2.2		 5igyA-4uzuA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkm XYLOSE ISOMERASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 ILE A 327
GLY A 332
ASN A 330
ALA A 288
PHE A 340
 None
 1.11A 5igyA-4xkmA:
undetectable		 5igyA-4xkmA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN

(Bordetella
bronchiseptica) 		PF03480
(DctP) 		5 GLY A 105
GLU A 140
PHE A 112
ILE A 147
MET A  85
 None
 1.13A 5igyA-4yzzA:
undetectable		 5igyA-4yzzA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnn CAPSID PROTEIN VP2

(Enterovirus D) 		PF00073
(Rhv) 		5 ILE B 108
GLU B 150
PHE B  63
SER B  68
ILE B 228
 None
 1.20A 5igyA-5bnnB:
undetectable		 5igyA-5bnnB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5y DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Colwellia
psychrerythraea) 		PF01791
(DeoC) 		5 ASN A 175
PHE A  76
ILE A 165
PHE A 164
MET A 184
 None
 1.23A 5igyA-5c5yA:
undetectable		 5igyA-5c5yA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5y DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Colwellia
psychrerythraea) 		PF01791
(DeoC) 		5 ILE A 165
GLY A 196
GLU A 147
ALA A 200
ILE A 219
 None
None
None
UNL  A 301 ( 4.2A)
None
 1.04A 5igyA-5c5yA:
undetectable		 5igyA-5c5yA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Cryptococcus
neoformans) 		PF02358
(Trehalose_PPase) 		5 ILE A 205
GLY A 267
GLU A 190
PHE A 218
ALA A 282
 None
 0.98A 5igyA-5dx9A:
undetectable		 5igyA-5dx9A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03552
(Cellulose_synt)
PF07238
(PilZ) 		5 GLY A 308
ALA A 405
SER A 113
ILE A 114
PHE A 115
 None
None
None
BGC  A 914 ( 4.7A)
BGC  A 913 ( 4.7A)
 1.16A 5igyA-5ej1A:
0.0		 5igyA-5ej1A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby SEPARASE

(Chaetomium
thermophilum) 		PF03568
(Peptidase_C50) 		5 ILE A1884
HIS A1830
GLY A1887
GLU A1835
ALA A1935
 None
 1.12A 5igyA-5fbyA:
undetectable		 5igyA-5fbyA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5goo ALKALINE INVERTASE

(Nostoc sp. PCC
7120) 		PF12899
(Glyco_hydro_100) 		5 GLY A 438
ALA A 396
SER A 456
ILE A 455
PHE A 454
 None
 1.01A 5igyA-5gooA:
undetectable		 5igyA-5gooA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		5 ILE A 406
GLY A 385
HIS A  47
GLU A 417
ILE A 358
 None
 0.86A 5igyA-5gslA:
undetectable		 5igyA-5gslA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 HIS A 106
GLY A 190
ASN A 192
ALA A 263
SER A  79
 None
 1.13A 5igyA-5hc4A:
undetectable		 5igyA-5hc4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hoe HYDROLASE

(Sinorhizobium
meliloti) 		PF13472
(Lipase_GDSL_2) 		5 ILE A 188
GLY A 185
ALA A 145
SER A  13
MET A  92
 None
None
None
PO4  A 301 (-2.5A)
None
 1.15A 5igyA-5hoeA:
undetectable		 5igyA-5hoeA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j2y REGULATORY PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 5 GLY A  47
ASN A  46
SER A  32
ILE A  36
PHE A  34
 None
 1.15A 5igyA-5j2yA:
undetectable		 5igyA-5j2yA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m11 IMMUNOREACTIVE 84KD
ANTIGEN PG93

(Porphyromonas
gingivalis) 		no annotation 5 GLY A 673
ASN A 332
ALA A  54
SER A  76
ILE A  75
 None
 1.18A 5igyA-5m11A:
undetectable		 5igyA-5m11A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzb D-AMINOPEPTIDASE

(Burkholderia
sp. LK4) 		PF03576
(Peptidase_S58) 		5 ILE A 329
GLY A 179
ASN A 331
ILE A 244
PHE A 281
 None
 1.14A 5igyA-5tzbA:
undetectable		 5igyA-5tzbA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z2g L-AMINO ACID OXIDASE

(Naja atra) 		no annotation 5 GLY A 480
PHE A  30
ALA A 244
ILE A 116
PHE A  38
 FAD  A 604 (-4.0A)
None
None
None
None
 1.14A 5igyA-5z2gA:
undetectable		 5igyA-5z2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 ILE H 319
GLY H 287
ASN H 286
GLU H 310
PHE H 282
 None
 0.98A 5igyA-6chsH:
undetectable		 5igyA-6chsH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmz DIHYDROLIPOYL
DEHYDROGENASE

(Burkholderia
cenocepacia) 		no annotation 5 ILE A 354
GLY A 412
ALA A 419
SER A  51
ILE A  55
 None
None
None
FAD  A 502 (-3.6A)
None
 1.01A 5igyA-6cmzA:
undetectable		 5igyA-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elq CARBON MONOXIDE
DEHYDROGENASE

(Carboxydothermus
hydrogenoformans) 		no annotation 5 GLY X 523
ASN X 298
HIS X  95
SER X 565
ILE X 566
 None
 1.16A 5igyA-6elqX:
undetectable		 5igyA-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6erc PEROXINECTIN A

(Dictyostelium
discoideum) 		no annotation 5 ILE A 170
GLY A 172
ASN A 173
ALA A 104
ILE A 243
 None
None
NA  A 609 (-3.3A)
HEM  A 604 ( 3.9A)
None
 1.24A 5igyA-6ercA:
undetectable		 5igyA-6ercA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bml STREPTOKINASE

(Streptococcus
dysgalactiae) 		PF02821
(Staphylokinase) 		4 ASP C 227
ILE C 230
ARG C 232
TYR C 243
 None
 1.46A 5igyA-1bmlC:
0.0		 5igyA-1bmlC:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cen CELLULASE CELC

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		4 TYR A 277
ILE A 300
TYR A 299
TYR A 200
 None
None
None
BGC  A 351 (-4.3A)
 1.24A 5igyA-1cenA:
undetectable		 5igyA-1cenA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)

(Homo sapiens) 		PF00168
(C2)
PF01735
(PLA2_B) 		4 ASP A 569
ILE A 561
ARG A 566
TYR A 223
 None
 1.26A 5igyA-1cjyA:
0.0		 5igyA-1cjyA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyg CYCLODEXTRIN
GLUCANOTRANSFERASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 ASP A  60
ILE A  54
TYR A  15
TYR A 384
 None
 1.05A 5igyA-1cygA:
0.0		 5igyA-1cygA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 ASP A  63
ILE A  57
TYR A  18
TYR A 388
 None
 1.11A 5igyA-1dedA:
0.0		 5igyA-1dedA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gll GLYCEROL KINASE

(Escherichia
coli) 		no annotation 4 ILE Y 425
ARG Y 389
TYR Y 483
TYR Y 355
 None
 1.19A 5igyA-1gllY:
0.0		 5igyA-1gllY:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3g CYCLOMALTODEXTRINASE

(Flavobacterium
sp. 92) 		PF00128
(Alpha-amylase)
PF09087
(Cyc-maltodext_N)
PF10438
(Cyc-maltodext_C) 		4 TYR A 450
ARG A 116
TYR A 180
TYR A 183
 None
 1.31A 5igyA-1h3gA:
2.3		 5igyA-1h3gA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hh4 RHO GDP-DISSOCIATION
INHIBITOR 1

(Homo sapiens) 		PF02115
(Rho_GDI) 		4 ASP D 440
ILE D 429
TYR D 428
TYR D 410
 None
None
None
GER  D1502 (-4.9A)
 1.29A 5igyA-1hh4D:
undetectable		 5igyA-1hh4D:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8t UDP-GALACTOPYRANOSE
MUTASE

(Escherichia
coli) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 TYR A 346
ILE A  57
TYR A 181
TYR A 151
 FAD  A 450 (-4.7A)
FAD  A 450 (-4.1A)
None
None
 0.89A 5igyA-1i8tA:
0.0		 5igyA-1i8tA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idu VANADIUM
CHLOROPEROXIDASE

(Curvularia
inaequalis) 		PF01569
(PAP2) 		4 ASP A  13
ILE A 472
ARG A 474
TYR A 288
 None
 1.35A 5igyA-1iduA:
undetectable		 5igyA-1iduA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 TYR A 274
ASP A 228
ILE A 253
TYR A  35
 None
 1.49A 5igyA-1iv8A:
2.5		 5igyA-1iv8A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcl CYCLODEXTRIN
GLYCOSYLTRANSFERASE

(Bacillus
circulans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 ASP A  63
ILE A  57
TYR A  18
TYR A 388
 None
 1.10A 5igyA-1kclA:
2.4		 5igyA-1kclA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1now BETA-HEXOSAMINIDASE
BETA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 TYR A 101
ILE A 283
ARG A 281
TYR A 277
 None
 1.42A 5igyA-1nowA:
undetectable		 5igyA-1nowA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otw COENZYME PQQ
SYNTHESIS PROTEIN C

(Klebsiella
pneumoniae) 		PF03070
(TENA_THI-4) 		4 TYR A 128
ASP A 186
ILE A  81
TYR A 175
 PQQ  A 500 (-4.6A)
None
None
PQQ  A 500 (-4.3A)
 1.20A 5igyA-1otwA:
undetectable		 5igyA-1otwA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pca PROCARBOXYPEPTIDASE
A PCPA

(Sus scrofa) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		4 TYR A 198
ASP A  36
ILE A  52
TYR A 248
 None
None
None
VAL  A 700 (-4.8A)
 1.26A 5igyA-1pcaA:
undetectable		 5igyA-1pcaA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450

(Sulfurisphaera
tokodaii) 		PF00067
(p450) 		4 ASP A 225
ILE A 299
ARG A 302
TYR A   2
 None
 1.03A 5igyA-1ue8A:
undetectable		 5igyA-1ue8A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 TYR A 606
ILE A  81
ARG A 373
TYR A 912
 NAG  A3001 (-4.6A)
None
None
EDO  A9004 ( 3.4A)
 1.40A 5igyA-1xc6A:
2.2		 5igyA-1xc6A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z14 VP2

(Rodent
protoparvovirus
1) 		PF00740
(Parvo_coat) 		4 TYR A 376
ASP A 399
ILE A 578
TYR A 558
 None
 1.32A 5igyA-1z14A:
undetectable		 5igyA-1z14A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4e CORONIN-1A

(Mus musculus) 		PF00400
(WD40)
PF08953
(DUF1899)
PF16300
(WD40_4) 		4 ASP A 278
ILE A 390
ARG A 325
TYR A 321
 None
 1.47A 5igyA-2b4eA:
3.8		 5igyA-2b4eA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi7 UDP-GALACTOPYRANOSE
MUTASE

(Klebsiella
pneumoniae) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 TYR A 349
ILE A  61
TYR A 185
TYR A 155
 FAD  A1385 (-4.8A)
FAD  A1385 (-4.3A)
None
None
 0.95A 5igyA-2bi7A:
undetectable		 5igyA-2bi7A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens;
Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2)
no annotation 		4 TYR A  68
ILE I 251
ARG I 249
TYR I 245
 None
 1.47A 5igyA-2gk1A:
undetectable		 5igyA-2gk1A:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 ASP I 175
ARG I 424
TYR N 456
TYR N 547
 None
 1.09A 5igyA-2gk1I:
undetectable		 5igyA-2gk1I:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjv ATP-DEPENDENT RNA
HELICASE DBPA

(Bacillus
subtilis) 		PF00271
(Helicase_C) 		4 TYR A 265
ASP A 233
ILE A 313
TYR A 315
 None
 1.17A 5igyA-2hjvA:
undetectable		 5igyA-2hjvA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6t DNAB REPLICATION
FORK HELICASE

(Thermus
aquaticus) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		4 ASP A 378
ILE A 414
ARG A 373
TYR A 396
 None
 1.08A 5igyA-2q6tA:
undetectable		 5igyA-2q6tA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qik UPF0131 PROTEIN YKQA

(Bacillus
subtilis) 		PF06094
(GGACT)
PF13772
(AIG2_2) 		4 TYR A 259
ASP A 149
ILE A 194
TYR A 131
 None
 1.39A 5igyA-2qikA:
undetectable		 5igyA-2qikA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 TYR A 136
ASP A 109
ILE A  88
TYR A 128
 None
 1.29A 5igyA-2z81A:
undetectable		 5igyA-2z81A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zf5 GLYCEROL KINASE

(Thermococcus
kodakarensis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ILE O 416
ARG O 382
TYR O 474
TYR O 348
 None
 1.28A 5igyA-2zf5O:
undetectable		 5igyA-2zf5O:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apq DNAJ HOMOLOG
SUBFAMILY C MEMBER
10

(Mus musculus) 		PF00085
(Thioredoxin)
PF00226
(DnaJ) 		4 TYR A 154
ASP A 126
TYR A 117
TYR A  84
 None
 1.35A 5igyA-3apqA:
undetectable		 5igyA-3apqA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgw DNAB-LIKE
REPLICATIVE HELICASE

(Bacillus phage
SPP1) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		4 ASP A 373
ILE A 409
ARG A 368
TYR A 391
 None
 1.03A 5igyA-3bgwA:
undetectable		 5igyA-3bgwA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh0 DNAB-LIKE
REPLICATIVE HELICASE

(Bacillus phage
SPP1) 		PF03796
(DnaB_C) 		4 ASP A 373
ILE A 409
ARG A 368
TYR A 391
 None
 1.00A 5igyA-3bh0A:
undetectable		 5igyA-3bh0A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjd PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE

(Pseudomonas
aeruginosa) 		PF14515
(HOASN)
PF14518
(Haem_oxygenas_2) 		4 ASP A 157
ARG A 150
TYR A 316
TYR A  65
 None
None
None
EDO  A 401 (-3.5A)
 1.44A 5igyA-3bjdA:
undetectable		 5igyA-3bjdA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		4 ASP A 168
ILE A 162
ARG A 161
TYR A 104
 None
 1.48A 5igyA-3blwA:
undetectable		 5igyA-3blwA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 ASP A  63
ILE A  57
TYR A  18
TYR A 388
 None
 1.04A 5igyA-3bmwA:
2.3		 5igyA-3bmwA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsm UNCHARACTERIZED
PROTEIN BACUNI_02894

(Bacteroides
uniformis) 		no annotation 4 ASP A 302
ARG A 279
TYR A 310
TYR A 323
 None
 1.11A 5igyA-3dsmA:
2.8		 5igyA-3dsmA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwk PENICILLIN-BINDING
PROTEIN 2

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		4 ASP A 241
ARG A 283
TYR A 210
TYR A 196
 None
SO4  A  22 (-2.9A)
None
None
 1.14A 5igyA-3dwkA:
undetectable		 5igyA-3dwkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris) 		PF08241
(Methyltransf_11) 		4 TYR A 158
ASP A 188
ARG A 149
TYR A  17
 None
None
None
SAM  A 221 (-3.8A)
 1.21A 5igyA-3e23A:
undetectable		 5igyA-3e23A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE

(Pseudomonas
putida) 		PF00180
(Iso_dh) 		4 ASP X 177
ILE X 171
ARG X 170
TYR X 104
 None
 1.23A 5igyA-3fmxX:
undetectable		 5igyA-3fmxX:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g25 GLYCEROL KINASE

(Staphylococcus
aureus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ILE A 424
ARG A 388
TYR A 482
TYR A 354
 None
 1.18A 5igyA-3g25A:
undetectable		 5igyA-3g25A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwj ARYLPHORIN

(Antheraea
pernyi) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 TYR A 573
ILE A 150
TYR A 129
TYR A 110
 None
 1.39A 5igyA-3gwjA:
undetectable		 5igyA-3gwjA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn7 UDP-N-ACETYLMURAMATE
-L-ALANINE LIGASE

(Psychrobacter
arcticus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 TYR A  53
ILE A  34
TYR A  35
TYR A 430
 None
 1.29A 5igyA-3hn7A:
undetectable		 5igyA-3hn7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hol TBPB

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 TYR A 215
ASP A 273
ILE A  65
TYR A 243
 None
 1.11A 5igyA-3holA:
undetectable		 5igyA-3holA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1i HOMOSERINE
O-ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		4 ASP A  89
ILE A  86
TYR A  31
TYR A  58
 None
 1.42A 5igyA-3i1iA:
undetectable		 5igyA-3i1iA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE

(Burkholderia
pseudomallei) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 TYR A 355
ASP A 349
ILE A 344
TYR A  38
 None
 1.27A 5igyA-3imlA:
undetectable		 5igyA-3imlA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8n POSSIBLE GLUTATHIONE
S-TRANSFERASE

(Rhodopseudomonas
palustris) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 TYR A 164
ASP A 171
ILE A 106
TYR A 110
 None
 1.39A 5igyA-3m8nA:
undetectable		 5igyA-3m8nA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus scrofa;
Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase)
PF00287
(Na_K-ATPase) 		4 TYR A1016
ILE A 991
TYR A 994
TYR B  39
 None
 1.27A 5igyA-3n23A:
undetectable		 5igyA-3n23A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n77 NUCLEOSIDE
TRIPHOSPHATASE NUDI

(Salmonella
enterica) 		PF00293
(NUDIX) 		4 ILE A  95
ARG A  73
TYR A  93
TYR A  90
 None
 1.45A 5igyA-3n77A:
undetectable		 5igyA-3n77A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2k BREVIANAMIDE F
PRENYLTRANSFERASE

(Aspergillus
fumigatus) 		PF11991
(Trp_DMAT) 		4 TYR A 446
ASP A 191
ILE A 112
TYR A 203
 DST  A 501 (-4.7A)
DST  A 501 ( 4.1A)
None
QRP  A 502 ( 3.4A)
 1.28A 5igyA-3o2kA:
undetectable		 5igyA-3o2kA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otn SUSD SUPERFAMILY
PROTEIN

(Parabacteroides
distasonis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 TYR A 184
ILE A 156
TYR A 152
TYR A 382
 None
 1.25A 5igyA-3otnA:
undetectable		 5igyA-3otnA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbo PHOSPHOSERINE
AMINOTRANSFERASE

(Yersinia pestis) 		PF00266
(Aminotran_5) 		4 ASP A 160
ILE A 291
ARG A 294
TYR A 276
 None
 1.02A 5igyA-3qboA:
undetectable		 5igyA-3qboA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 ASP A  38
ILE A 365
TYR A 146
TYR A 125
 None
None
None
Z99  A 485 ( 4.2A)
 1.30A 5igyA-3sm9A:
undetectable		 5igyA-3sm9A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssz MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Rhodobacteraceae
bacterium KLH11) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A 196
ILE A 169
TYR A 346
TYR A 374
 None
 1.46A 5igyA-3sszA:
undetectable		 5igyA-3sszA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stp GALACTONATE
DEHYDRATASE,
PUTATIVE

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A 173
ILE A 146
TYR A 323
TYR A 351
 None
 1.48A 5igyA-3stpA:
undetectable		 5igyA-3stpA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
ALPHA CHAIN
V-TYPE ATP SYNTHASE
BETA CHAIN

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 TYR A 353
ILE D  14
ARG A  41
TYR D  13
 None
 1.47A 5igyA-3w3aA:
undetectable		 5igyA-3w3aA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdg URACIL-DNA
GLYCOSYLASE

(Staphylococcus
aureus) 		PF03167
(UDG) 		4 ASP A 106
ILE A 211
TYR A 196
TYR A  88
 None
 1.33A 5igyA-3wdgA:
undetectable		 5igyA-3wdgA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wp9 ICE-BINDING PROTEIN

(Colwellia sp.
SLW05) 		PF11999
(DUF3494) 		4 ASP A  95
ILE A 137
ARG A  91
TYR A   4
 None
 1.25A 5igyA-3wp9A:
undetectable		 5igyA-3wp9A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 TYR A 405
ASP A 422
ILE A 373
TYR A  93
 None
 1.26A 5igyA-3zo9A:
2.8		 5igyA-3zo9A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpy ALGINATE LYASE,
FAMILY PL7

(Zobellia
galactanivorans) 		PF08787
(Alginate_lyase2) 		4 TYR A 420
ASP A 335
ILE A 322
TYR A 414
 None
 1.25A 5igyA-3zpyA:
undetectable		 5igyA-3zpyA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1f REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF03796
(DnaB_C) 		4 ASP A 371
ILE A 441
ARG A 366
TYR A 389
 None
 1.02A 5igyA-4a1fA:
undetectable		 5igyA-4a1fA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION

(Staphylothermus
marinus) 		PF00128
(Alpha-amylase) 		4 ASP A 272
ILE A 267
TYR A 229
TYR A 598
 None
 1.36A 5igyA-4aeeA:
undetectable		 5igyA-4aeeA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aef NEOPULLULANASE
(ALPHA-AMYLASE II)

(Pyrococcus
furiosus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16561
(AMPK1_CBM) 		4 TYR A 456
ILE A 435
TYR A 257
TYR A 270
 None
 1.47A 5igyA-4aefA:
undetectable		 5igyA-4aefA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ee8 PRENYLTRANSFERASE

(Streptomyces
cinnamonensis) 		PF11468
(PTase_Orf2) 		4 TYR A 281
ASP A  60
ILE A 284
TYR A 174
 SO4  A 402 (-4.5A)
None
None
SO4  A 401 (-4.6A)
 1.30A 5igyA-4ee8A:
undetectable		 5igyA-4ee8A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4en8 HEMAGGLUTININ
COMPONENTS
HA-22/23/53

(Clostridium
botulinum) 		PF03505
(Clenterotox) 		4 TYR B 613
ILE B 316
TYR B 214
TYR B 429
 None
 1.46A 5igyA-4en8B:
undetectable		 5igyA-4en8B:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcy TRANSPOSASE

(Escherichia
virus Mu) 		PF02316
(HTH_Tnp_Mu_1)
PF02914
(DDE_2)
PF09039
(HTH_Tnp_Mu_2)
PF09299
(Mu-transpos_C) 		4 ASP A 306
ILE A 311
ARG A 315
TYR A 354
 None
 1.04A 5igyA-4fcyA:
undetectable		 5igyA-4fcyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwb HALOALKANE
DEHALOGENASE

(Rhodococcus
rhodochrous) 		PF00561
(Abhydrolase_1) 		4 TYR A 225
ASP A 106
ILE A 247
ARG A 133
 None
3KP  A2001 ( 2.3A)
None
None
 1.00A 5igyA-4fwbA:
undetectable		 5igyA-4fwbA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4s PROTEASOME ASSEMBLY
CHAPERONE 2

(Saccharomyces
cerevisiae) 		PF09754
(PAC2) 		4 TYR P  59
ASP P  20
ILE P 247
ARG P  50
 None
 1.38A 5igyA-4g4sP:
undetectable		 5igyA-4g4sP:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F

(Bacillus
subtilis) 		PF12895
(ANAPC3)
PF13424
(TPR_12) 		4 ASP A 338
ARG A 115
TYR A 300
TYR A 226
 None
 1.40A 5igyA-4i9cA:
undetectable		 5igyA-4i9cA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 ASP A  80
ILE A  85
TYR A 379
TYR A 603
 None
None
None
NAG  A1137 (-4.7A)
 1.48A 5igyA-4iugA:
2.3		 5igyA-4iugA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 ASP A  63
ILE A  57
TYR A  18
TYR A 389
 None
 1.06A 5igyA-4jclA:
2.2		 5igyA-4jclA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 TYR A 360
ARG A  24
TYR A  97
TYR A 100
 None
None
None
GOL  A 711 ( 4.0A)
 1.29A 5igyA-4jclA:
2.2		 5igyA-4jclA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo0 CMLA

(Streptomyces
venezuelae) 		PF12706
(Lactamase_B_2) 		4 ASP A 403
ILE A 432
ARG A 457
TYR A 440
 FE  A 602 ( 2.6A)
None
None
None
 1.46A 5igyA-4jo0A:
undetectable		 5igyA-4jo0A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo2 UDP-GALACTOPYRANOSE
MUTASE

(Campylobacter
jejuni) 		no annotation 4 TYR B 345
ILE B  57
TYR B 180
TYR B 150
 FDA  B 402 (-4.6A)
FDA  B 402 (-4.2A)
None
None
 0.91A 5igyA-4mo2B:
undetectable		 5igyA-4mo2B:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ncj DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		4 ASP A  41
ILE A  71
ARG A  86
TYR A 129
 None
 1.24A 5igyA-4ncjA:
undetectable		 5igyA-4ncjA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o3x TRANSFERRIN BINDING
PROTEIN B

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17484
(TbpB_A) 		4 TYR B 215
ASP B 273
ILE B  65
TYR B 243
 None
 1.11A 5igyA-4o3xB:
undetectable		 5igyA-4o3xB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4x TBPB

(Glaesserella
parasuis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 TYR A 220
ASP A 278
ILE A  65
TYR A 248
 None
 1.07A 5igyA-4o4xA:
undetectable		 5igyA-4o4xA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8u UNCHARACTERIZED
PROTEIN PF2046

(Pyrococcus
furiosus) 		PF13680
(DUF4152) 		4 TYR A  58
ASP A  15
ILE A  66
ARG A  63
 None
 1.12A 5igyA-4o8uA:
undetectable		 5igyA-4o8uA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oz5 BACILLUS SUBTILIS
HMOB

(Bacillus
subtilis) 		PF03992
(ABM) 		4 TYR A  52
ASP A 111
ILE A  72
TYR A 158
 None
 1.28A 5igyA-4oz5A:
undetectable		 5igyA-4oz5A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE

(Escherichia
coli) 		PF06315
(AceK) 		4 TYR A  86
ASP A  18
ILE A  98
TYR A  54
 None
 1.49A 5igyA-4p69A:
5.8		 5igyA-4p69A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qre METHIONYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 TYR A 127
ARG A 217
TYR A 235
TYR A  14
 None
None
3BG  A 601 (-4.7A)
3BG  A 601 (-3.5A)
 1.40A 5igyA-4qreA:
undetectable		 5igyA-4qreA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru5 TAILSPIKE GP27

(Pseudomonas
phage phi297) 		no annotation 4 TYR A 384
ASP A 473
ILE A 417
TYR A 304
 None
 1.30A 5igyA-4ru5A:
undetectable		 5igyA-4ru5A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufc GH95

(Bacteroides
ovatus) 		PF14498
(Glyco_hyd_65N_2) 		4 TYR A 657
ASP A 670
ILE A 615
ARG A 655
 None
 1.27A 5igyA-4ufcA:
undetectable		 5igyA-4ufcA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN ALPHA-V
INTEGRIN BETA-6

(Homo sapiens;
Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		4 TYR B 292
ASP A 219
ILE B 219
TYR B 321
 None
 1.36A 5igyA-4um8B:
undetectable		 5igyA-4um8B:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uop LIPOTEICHOIC ACID
PRIMASE

(Listeria
monocytogenes) 		PF00884
(Sulfatase) 		4 TYR A 453
ILE A 232
TYR A 386
TYR A 338
 None
 1.32A 5igyA-4uopA:
undetectable		 5igyA-4uopA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		4 TYR A 193
ASP A 298
ILE A 274
TYR A 122
 None
 1.48A 5igyA-4us4A:
undetectable		 5igyA-4us4A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Pyrococcus
horikoshii) 		PF01867
(Cas_Cas1) 		4 ASP A  39
ILE A  42
TYR A  43
TYR A 275
 None
 1.46A 5igyA-4wj0A:
undetectable		 5igyA-4wj0A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 TYR A 201
ASP A 182
ILE A 196
TYR A 227
 None
 1.31A 5igyA-4yv7A:
undetectable		 5igyA-4yv7A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zc0 REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		4 ASP A 371
ILE A 441
ARG A 366
TYR A 389
 None
 1.06A 5igyA-4zc0A:
undetectable		 5igyA-4zc0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT
NA+,K+-ATPASE BETA
SUBUNIT

(Squalus
acanthias;
Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase)
PF00287
(Na_K-ATPase) 		4 TYR A1023
ILE A 998
TYR A1001
TYR B  40
 None
None
None
CLR  B3001 ( 4.0A)
 1.02A 5igyA-5aw4A:
undetectable		 5igyA-5aw4A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT

(Azospira oryzae) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 TYR A 549
ILE A 500
ARG A 855
TYR A 756
 None
 1.23A 5igyA-5chcA:
undetectable		 5igyA-5chcA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flw EXO-BETA-1,3-GALACTA
NASE

(Bifidobacterium
bifidum) 		PF04616
(Glyco_hydro_43) 		4 TYR A 256
ILE A 193
TYR A 150
TYR A 169
 None
 1.33A 5igyA-5flwA:
undetectable		 5igyA-5flwA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2t TREHALOSE SYNTHASE

(Thermomonospora
curvata) 		no annotation 4 TYR A 392
ASP A 409
ILE A 360
TYR A  80
 None
 1.33A 5igyA-5h2tA:
2.8		 5igyA-5h2tA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6b PUTATIVE SECRETED
LIPASE

(Streptomyces
sp. W007) 		PF01674
(Lipase_2) 		4 TYR A 199
ASP A 223
ILE A 241
TYR A 210
 None
 1.48A 5igyA-5h6bA:
undetectable		 5igyA-5h6bA:
21.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II

(Escherichia
coli) 		PF01636
(APH) 		4 ASP A 200
ILE A 233
ARG A 237
TYR A 273
 None
 0.46A 5igyA-5iguA:
31.0		 5igyA-5iguA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkj ESTERASE E22

(uncultured
bacterium) 		PF00561
(Abhydrolase_1) 		4 ASP A 112
ILE A 109
TYR A  54
TYR A  81
 None
 1.47A 5igyA-5jkjA:
undetectable		 5igyA-5jkjA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		4 TYR A 533
ILE A 490
ARG A 527
TYR A 342
 None
 1.37A 5igyA-5jlcA:
undetectable		 5igyA-5jlcA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mso CARBOXYLIC ACID
REDUCTASE

(Mycobacterium
marinum) 		PF07993
(NAD_binding_4) 		4 TYR A1033
ASP A1000
TYR A1121
TYR A 952
 None
 1.37A 5igyA-5msoA:
undetectable		 5igyA-5msoA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd4 TUBULIN ALPHA CHAIN

(Bos taurus) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 TYR A 161
ASP A 120
ILE A 115
ARG A 156
 None
 1.36A 5igyA-5nd4A:
undetectable		 5igyA-5nd4A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tta PUTATIVE EXPORTED
PROTEIN

(Clostridioides
difficile) 		no annotation 4 TYR A 252
ILE A  69
TYR A 272
TYR A 108
 None
 1.48A 5igyA-5ttaA:
undetectable		 5igyA-5ttaA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es9 ACYL-COA
DEHYDROGENASE

(Paracoccus
denitrificans) 		no annotation 4 TYR A 381
ASP A 197
ARG A 324
TYR A 243
 None
 1.22A 5igyA-6es9A:
undetectable		 5igyA-6es9A:
undetectable