SIMILAR PATTERNS OF AMINO ACIDS FOR 5IGW_A_CTYA404_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II

(Synechocystis
sp. PCC 6803) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A 361
GLY A 259
GLU A 353
SER A 171
ILE A 174
 None
 1.20A 5igwA-1e5mA:
0.0		 5igwA-1e5mA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hx6 MAJOR CAPSID PROTEIN

(Salmonella
virus PRD1) 		PF09018
(Phage_Capsid_P3) 		5 GLY A 114
SER A 131
ILE A 148
PHE A 129
MET A 164
 None
 1.12A 5igwA-1hx6A:
0.0		 5igwA-1hx6A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1io0 TROPOMODULIN

(Gallus gallus) 		no annotation 5 ILE A 269
GLY A 268
GLU A 284
SER A 230
ILE A 231
 None
 1.12A 5igwA-1io0A:
0.0		 5igwA-1io0A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5y SURVIVAL PROTEIN
SURA

(Escherichia
coli) 		PF00639
(Rotamase)
PF09312
(SurA_N)
PF13616
(Rotamase_3) 		5 GLY A 317
ARG A 288
SER A 329
ILE A 290
PHE A 328
 None
 1.41A 5igwA-1m5yA:
undetectable		 5igwA-1m5yA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyw ATP-DEPENDENT DNA
HELICASE

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		5 ILE A 213
GLY A 325
ILE A 317
PHE A 374
TYR A 320
 None
 1.33A 5igwA-1oywA:
0.0		 5igwA-1oywA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5i IA-1=SERINE
PROTEINASE INHIBITOR

(Pleurotus
ostreatus) 		no annotation 5 ILE B  32
GLY B  46
GLU B  15
ILE B   8
TYR B  36
 None
 1.40A 5igwA-1v5iB:
0.0		 5igwA-1v5iB:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlc CONGERIN II

(Conger
myriaster) 		PF00337
(Gal-bind_lectin) 		5 ILE A  41
GLY A  35
TYR A 122
ASP A  46
ILE A  99
 None
None
MES  A 777 (-4.8A)
None
None
 1.44A 5igwA-1wlcA:
0.7		 5igwA-1wlcA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 SARCOSINE OXIDASE

(Pyrococcus
horikoshii) 		PF01266
(DAO) 		5 TYR B 308
SER B 244
PHE B  89
TYR B  87
MET B 241
 FAD  B 800 ( 4.9A)
None
None
None
None
 1.40A 5igwA-1y56B:
0.0		 5igwA-1y56B:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zb7 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		5 ILE A 160
ASP A 173
ILE A 138
PHE A  25
MET A  22
 None
 1.37A 5igwA-1zb7A:
0.0		 5igwA-1zb7A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'

(Medicago
truncatula) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 GLY A 208
ASP A 299
SER A 275
ILE A 278
MET A 251
 SAH  A3994 ( 4.3A)
None
None
None
SAH  A3994 (-3.6A)
 1.39A 5igwA-1zgjA:
undetectable		 5igwA-1zgjA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ab4 TRNA PSEUDOURIDINE
SYNTHASE B

(Thermotoga
maritima) 		PF01472
(PUA)
PF01509
(TruB_N)
PF16198
(TruB_C_2) 		5 ILE A   5
GLY A  49
TYR A  60
HIS A 199
ARG A 193
 None
 1.27A 5igwA-2ab4A:
undetectable		 5igwA-2ab4A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		5 ILE A 552
GLY A 556
SER A 524
ILE A 528
MET A 400
 None
 1.27A 5igwA-2b0tA:
undetectable		 5igwA-2b0tA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b30 PVIVAX HYPOTHETICAL
PROTEIN

(Plasmodium
vivax) 		PF08282
(Hydrolase_3) 		5 ILE A 115
TYR A 120
GLU A 217
SER A  71
ILE A 101
 None
 1.38A 5igwA-2b30A:
undetectable		 5igwA-2b30A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9l PROPHENOLOXIDASE
ACTIVATING FACTOR

(Holotrichia
diomphalia) 		PF00089
(Trypsin) 		5 ILE A 373
GLY A 354
SER A 242
ILE A 240
PHE A 244
 None
 1.41A 5igwA-2b9lA:
undetectable		 5igwA-2b9lA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 GLY A  91
TYR A 313
SER A 144
ILE A 148
TYR A 151
 None
 1.32A 5igwA-2c9kA:
undetectable		 5igwA-2c9kA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csd TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		5 ILE A 225
GLY A 224
TYR A 226
HIS A 200
GLU A 202
 None
 1.37A 5igwA-2csdA:
3.6		 5igwA-2csdA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfk COLLYBISTIN II

(Rattus
norvegicus) 		PF00169
(PH)
PF00621
(RhoGEF) 		5 ASP A 291
HIS A 292
GLU A 265
ILE A 380
PHE A 382
 None
 1.41A 5igwA-2dfkA:
undetectable		 5igwA-2dfkA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 ILE A 314
GLY A  74
HIS A 265
GLU A 267
ILE A  54
 None
 1.42A 5igwA-2f3oA:
undetectable		 5igwA-2f3oA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqz R.ECL18KI

(Enterobacter
cloacae) 		PF09019
(EcoRII-C) 		5 GLY A  36
SER A 126
ILE A 127
TYR A  52
MET A  56
 None
 1.43A 5igwA-2fqzA:
undetectable		 5igwA-2fqzA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfi PHYTASE

(Debaryomyces
castellii) 		PF00328
(His_Phos_2) 		5 ILE A 348
GLY A 347
SER A  71
ILE A 339
PHE A  70
 None
 1.29A 5igwA-2gfiA:
undetectable		 5igwA-2gfiA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Aquifex
aeolicus) 		PF03331
(LpxC) 		5 ILE A  18
GLY A 210
ASP A 242
HIS A  79
ARG A 190
 TUX  A 901 ( 4.9A)
TUX  A 901 ( 3.9A)
ZN  A 601 ( 2.2A)
ZN  A 601 ( 3.3A)
None
 1.19A 5igwA-2go4A:
undetectable		 5igwA-2go4A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 ILE A 117
GLY A 441
GLU A 174
SER A 123
ILE A 122
 None
 1.24A 5igwA-2htvA:
undetectable		 5igwA-2htvA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 ILE A 806
TYR A 823
HIS A 908
SER A 768
ILE A 751
 None
 1.34A 5igwA-2i1yA:
undetectable		 5igwA-2i1yA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icg LIN2918 PROTEIN

(Listeria
innocua) 		PF14568
(SUKH_6) 		5 GLY A  60
GLU A 125
SER A 109
ILE A  99
PHE A 146
 None
 1.43A 5igwA-2icgA:
undetectable		 5igwA-2icgA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwh CARBOHYDRATE KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		5 TYR A 113
ASP A  13
HIS A  11
GLU A  35
ARG A  60
 None
None
CL  A 403 ( 4.9A)
None
None
 0.93A 5igwA-2nwhA:
undetectable		 5igwA-2nwhA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vug PAB1020

(Pyrococcus
abyssi) 		PF09414
(RNA_ligase) 		5 ILE A 218
GLY A 228
TYR A 242
GLU A 287
ILE A 249
 None
 1.29A 5igwA-2vugA:
undetectable		 5igwA-2vugA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x32 CELLULOSE-BINDING
PROTEIN

(Saccharophagus
degradans) 		PF04264
(YceI) 		5 ILE A  35
GLY A  34
TYR A   3
ARG A 124
PHE A 166
 None
None
None
None
OTP  A1174 (-4.4A)
 1.23A 5igwA-2x32A:
undetectable		 5igwA-2x32A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhz ARABINOSE
5-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF01380
(SIS) 		5 ILE A  63
GLY A  61
ASP A 172
SER A  73
PHE A  71
 None
 1.16A 5igwA-2xhzA:
undetectable		 5igwA-2xhzA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like) 		5 ASP A  26
HIS A  29
SER A  23
ILE A 242
MET A 221
 None
 1.06A 5igwA-3abzA:
1.6		 5igwA-3abzA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 ILE A 117
GLY A 441
GLU A 174
SER A 123
ILE A 122
 None
 1.19A 5igwA-3ckzA:
undetectable		 5igwA-3ckzA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcp HISTIDINOL-PHOSPHATA
SE

(Listeria
monocytogenes) 		PF02811
(PHP)
PF13263
(PHP_C) 		5 ILE A  98
GLY A 162
ILE A 145
PHE A 148
TYR A 149
 None
 1.01A 5igwA-3dcpA:
undetectable		 5igwA-3dcpA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		5 GLY A 339
TYR A 517
GLU A 486
SER A 456
ILE A 454
 None
 1.22A 5igwA-3decA:
undetectable		 5igwA-3decA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dja PROTEIN CT_858

(Chlamydia
trachomatis) 		PF03572
(Peptidase_S41) 		5 GLY A 284
SER A 125
ILE A 575
PHE A 570
TYR A 580
 None
 1.38A 5igwA-3djaA:
undetectable		 5igwA-3djaA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epm THIAMINE
BIOSYNTHESIS PROTEIN
THIC

(Caulobacter
vibrioides) 		PF01964
(ThiC_Rad_SAM)
PF13667
(ThiC-associated) 		5 ILE A 271
GLY A 272
HIS A 200
GLU A 204
MET A 472
 None
 1.33A 5igwA-3epmA:
undetectable		 5igwA-3epmA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggd SAM-DEPENDENT
METHYLTRANSFERASE

(Trichormus
variabilis) 		PF13649
(Methyltransf_25) 		5 ILE A 193
GLY A 192
HIS A 135
ILE A 168
PHE A 171
 None
None
SAH  A 248 ( 4.5A)
SO4  A 250 (-3.6A)
None
 1.27A 5igwA-3ggdA:
undetectable		 5igwA-3ggdA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtt SUPEROXIDE DISMUTASE
[CU-ZN]

(Mus musculus) 		PF00080
(Sod_Cu) 		5 ILE A 113
GLY A 114
GLU A  21
SER A  32
ILE A  18
 None
 1.37A 5igwA-3gttA:
undetectable		 5igwA-3gttA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7r ALDO-KETO REDUCTASE

(Arabidopsis
thaliana) 		PF00248
(Aldo_ket_red) 		5 GLY A 206
HIS A 247
SER A 279
ILE A 281
PHE A 278
 NAP  A 401 (-4.2A)
None
None
None
None
 1.23A 5igwA-3h7rA:
undetectable		 5igwA-3h7rA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hp0 PUTATIVE POLYKETIDE
BIOSYNTHESIS
ENOYL-COA HYDRATASE
HOMOLOG PKSH

(Bacillus
subtilis) 		PF00378
(ECH_1) 		5 GLY A 156
SER A 171
ILE A 170
PHE A 133
MET A 163
 None
 1.44A 5igwA-3hp0A:
undetectable		 5igwA-3hp0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k55 BETA-HEMOLYSIN

(Staphylococcus
aureus) 		PF03372
(Exo_endo_phos) 		5 ILE A  37
GLY A  38
TYR A  42
HIS A  15
GLU A  53
 None
 1.31A 5igwA-3k55A:
undetectable		 5igwA-3k55A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Babesia bovis) 		PF00274
(Glycolytic) 		5 GLY A 138
TYR A 135
SER A  18
ILE A  20
PHE A  19
 None
 1.26A 5igwA-3kx6A:
0.6		 5igwA-3kx6A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7d TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24) 		5 ILE A 225
GLY A 224
TYR A 226
HIS A 200
GLU A 202
 None
 1.39A 5igwA-3m7dA:
1.2		 5igwA-3m7dA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8u HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		5 ILE A 288
GLY A 428
HIS A 500
ILE A 318
MET A 388
 None
GDS  A   1 (-3.6A)
None
None
None
 0.98A 5igwA-3m8uA:
undetectable		 5igwA-3m8uA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myu HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37

(Mycoplasma
genitalium) 		PF06646
(Mycoplasma_p37) 		5 ILE A 343
GLY A 344
ILE A 111
PHE A 328
TYR A 348
 VIB  A 500 (-4.8A)
VIB  A 500 (-3.6A)
None
None
None
 1.22A 5igwA-3myuA:
undetectable		 5igwA-3myuA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n4t APH(2'')-ID

(Enterococcus
casseliflavus) 		PF01636
(APH) 		5 ILE A 277
TYR A 278
GLU A 148
ILE A 180
TYR A 177
 None
 0.88A 5igwA-3n4tA:
22.0		 5igwA-3n4tA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0d TRIACYLGLYCEROL
LIPASE

(Yarrowia
lipolytica) 		PF01764
(Lipase_3)
PF03893
(Lipase3_N) 		5 GLY A 172
TYR A 133
GLU A  57
SER A 146
ILE A 148
 None
 1.42A 5igwA-3o0dA:
undetectable		 5igwA-3o0dA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1

(Homo sapiens) 		PF00621
(RhoGEF) 		5 ILE A 575
GLY A 576
GLU A 428
ARG A 481
PHE A 500
 None
 1.17A 5igwA-3odxA:
undetectable		 5igwA-3odxA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogz UDP-SUGAR
PYROPHOSPHORYLASE

(Leishmania
major) 		PF01704
(UDPGP) 		5 GLY A  57
TYR A  62
ASP A 226
HIS A 222
ARG A 219
 None
 1.27A 5igwA-3ogzA:
undetectable		 5igwA-3ogzA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9c ACETYLPOLYAMINE
AMIDOHYDROLASE

(Mycoplana
ramosa) 		PF00850
(Hist_deacetyl) 		5 ILE A 291
ASP A 195
HIS A 197
GLU A 320
ILE A 328
 Q9C  A 401 ( 4.4A)
ZN  A 343 (-2.3A)
ZN  A 343 (-3.4A)
None
None
 1.43A 5igwA-3q9cA:
undetectable		 5igwA-3q9cA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stb MP18 RNA EDITING
COMPLEX PROTEIN
RNA-EDITING COMPLEX
PROTEIN MP42

(Trypanosoma
brucei) 		PF00436
(SSB)
no annotation 		5 GLY D  97
ASP D  68
HIS D  70
ILE C 381
MET C 294
 None
 1.41A 5igwA-3stbD:
undetectable		 5igwA-3stbD:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw5 TRANSGLUTAMINASE
ELICITOR

(Phytophthora
sojae) 		PF16683
(TGase_elicitor) 		5 GLY A 481
TYR A 468
HIS A 368
GLU A 182
ILE A 170
 None
 1.20A 5igwA-3tw5A:
undetectable		 5igwA-3tw5A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vis ESTERASE

(Thermobifida
alba) 		PF12740
(Chlorophyllase2) 		5 ILE A 113
GLY A 110
ASP A 270
ILE A 158
MET A 146
 None
 1.20A 5igwA-3visA:
undetectable		 5igwA-3visA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voo FATTY ACID
ALPHA-HYDROXYLASE

(Sphingomonas
paucimobilis) 		PF00067
(p450) 		5 ILE A 263
TYR A 273
GLU A 331
PHE A 284
TYR A 285
 None
 1.34A 5igwA-3vooA:
undetectable		 5igwA-3vooA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6o DYNAMIN-1-LIKE
PROTEIN

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		5 ILE A 166
GLY A 149
SER A 175
ILE A 174
PHE A 173
 None
GCP  A 801 (-3.6A)
None
None
None
 1.04A 5igwA-3w6oA:
undetectable		 5igwA-3w6oA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		5 ILE A 345
GLY A 344
TYR A 347
GLU A 247
ILE A 267
 None
 1.22A 5igwA-4a5wA:
undetectable		 5igwA-4a5wA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7j NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 ILE A 117
GLY A 440
GLU A 175
SER A 123
ILE A 122
 None
 1.20A 5igwA-4b7jA:
undetectable		 5igwA-4b7jA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cg1 CUTINASE

(Thermobifida
fusca) 		PF12740
(Chlorophyllase2) 		5 ILE A  74
GLY A  71
ASP A 231
ILE A 119
MET A 107
 None
 1.22A 5igwA-4cg1A:
undetectable		 5igwA-4cg1A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvt POST-PROLINE
CLEAVING ENZYME

(Rickettsia
typhi) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 ILE A 472
GLY A 471
SER A 417
ILE A 418
TYR A 447
 None
 1.20A 5igwA-4hvtA:
undetectable		 5igwA-4hvtA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN

(Homo sapiens;
Rattus
norvegicus) 		PF00012
(HSP70) 		5 ILE A 297
ASP A 234
GLU A 268
SER A 340
ILE A 343
 IOD  A 615 (-4.7A)
ADP  A 601 ( 4.9A)
ADP  A 601 ( 3.0A)
ADP  A 601 (-3.4A)
None
 1.38A 5igwA-4j8fA:
undetectable		 5igwA-4j8fA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc8 HOPS COMPONENT VPS33

(Chaetomium
thermophilum) 		PF00995
(Sec1) 		5 ILE A 262
GLY A 261
ASP A 303
SER A 363
ILE A 366
 None
 1.38A 5igwA-4jc8A:
undetectable		 5igwA-4jc8A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE

(Francisella
philomiragia) 		PF01048
(PNP_UDP_1) 		5 ILE A 170
GLY A  79
ASP A  99
HIS A  98
ILE A  51
 ADE  A 301 ( 4.9A)
ADE  A 301 (-3.7A)
None
None
None
 1.34A 5igwA-4josA:
undetectable		 5igwA-4josA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kgk THG1-LIKE
UNCHARACTERIZED
PROTEIN

(Bacillus
thuringiensis) 		PF04446
(Thg1) 		5 ILE A 200
GLY A 199
HIS A 221
GLU A 205
TYR A 232
 None
 1.42A 5igwA-4kgkA:
undetectable		 5igwA-4kgkA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kyz DESIGNED PROTEIN
OR327

(synthetic
construct) 		no annotation 5 ILE A  40
TYR A  76
ARG A  47
PHE A  17
TYR A  19
 None
 1.43A 5igwA-4kyzA:
undetectable		 5igwA-4kyzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li3 CYSTEINE SYNTHASE

(Haemophilus
influenzae) 		PF00291
(PALP) 		5 ILE X 229
GLY X 175
HIS X 224
ILE X 234
PHE X 233
 LLP  X  42 ( 4.7A)
None
None
None
None
 1.18A 5igwA-4li3X:
undetectable		 5igwA-4li3X:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lma CYSTEINE SYNTHASE

(Microcystis
aeruginosa) 		PF00291
(PALP) 		5 ILE A 226
GLY A 179
HIS A 221
ILE A 231
PHE A 230
 PLP  A 403 (-4.7A)
None
None
None
None
 1.16A 5igwA-4lmaA:
undetectable		 5igwA-4lmaA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mxn UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		PF00295
(Glyco_hydro_28) 		5 ILE A 116
GLY A 117
GLU A  72
SER A  52
ILE A  51
 None
 1.38A 5igwA-4mxnA:
undetectable		 5igwA-4mxnA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdy PARATHION HYDROLASE

(Vulcanisaeta
moutnovskia) 		PF02126
(PTE) 		5 GLY A  72
ASP A 257
HIS A  25
SER A 172
TYR A 100
 None
CO  A 401 ( 2.5A)
CO  A 401 ( 3.3A)
None
GOL  A 406 (-3.8A)
 1.31A 5igwA-4rdyA:
undetectable		 5igwA-4rdyA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rma EZRIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 ILE A 238
GLY A 239
SER A 249
ILE A 248
PHE A 255
 None
 0.97A 5igwA-4rmaA:
2.0		 5igwA-4rmaA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmu RECQ

(Cronobacter
sakazakii) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		5 ILE A 213
GLY A 325
ILE A 317
PHE A 374
TYR A 320
 None
 1.38A 5igwA-4tmuA:
undetectable		 5igwA-4tmuA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		5 ILE A  55
GLY A  53
TYR A  51
GLU A  66
ILE A 440
 None
 1.43A 5igwA-4us4A:
undetectable		 5igwA-4us4A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 ILE A 656
GLY A 653
ASP A 664
GLU A 665
PHE A 668
 None
 1.37A 5igwA-4wjlA:
2.9		 5igwA-4wjlA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8i LYSYL AMINOPEPTIDASE

(Pyrococcus
furiosus) 		PF05343
(Peptidase_M42) 		5 ILE A  67
GLY A  68
ASP A 230
ARG A 179
SER A 204
 None
None
ZN  A 401 ( 1.8A)
None
None
 1.39A 5igwA-4x8iA:
undetectable		 5igwA-4x8iA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb3 GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Streptococcus
mutans) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 ILE A 244
GLY A 239
TYR A 248
HIS A 215
ILE A 207
 None
 1.34A 5igwA-4xb3A:
undetectable		 5igwA-4xb3A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xf5 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Chromohalobacter
salexigens) 		PF03480
(DctP) 		5 ILE A 213
GLY A 212
ASP A 155
SER A 239
ILE A 238
 None
None
2A1  A 403 (-2.8A)
None
None
 1.11A 5igwA-4xf5A:
undetectable		 5igwA-4xf5A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3c SIR2 FAMILY PROTEIN

(Streptococcus
pyogenes) 		no annotation 5 GLY A  41
TYR A  44
GLU A 139
ILE A  32
TYR A 100
 None
NAD  A1294 (-3.5A)
None
None
None
 1.32A 5igwA-5a3cA:
undetectable		 5igwA-5a3cA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Homo sapiens) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
PF09336
(Vps4_C) 		5 ILE A 371
GLY A 370
HIS A 404
SER A 541
ILE A 540
 None
 1.27A 5igwA-5c1bA:
undetectable		 5igwA-5c1bA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 ILE A 293
GLY A 292
ASP A  86
HIS A 377
ILE A 201
 None
 1.27A 5igwA-5dotA:
1.4		 5igwA-5dotA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqp EDTA MONOOXYGENASE

(EDTA-degrading
bacterium BNC1) 		PF00296
(Bac_luciferase) 		5 ILE A  89
GLY A  90
TYR A 413
GLU A 393
ILE A 383
 None
 1.23A 5igwA-5dqpA:
undetectable		 5igwA-5dqpA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7v LMO0181 PROTEIN

(Listeria
monocytogenes) 		PF01547
(SBP_bac_1) 		5 ILE A 303
GLY A 302
GLU A 313
SER A 111
ILE A 113
 None
 1.40A 5igwA-5f7vA:
undetectable		 5igwA-5f7vA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fno MANGANESE
LIPOXYGENASE

(Magnaporthe
oryzae) 		PF00305
(Lipoxygenase) 		5 ILE A 291
GLY A 361
TYR A 287
HIS A 460
GLU A 456
 None
 1.35A 5igwA-5fnoA:
undetectable		 5igwA-5fnoA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		5 ILE A 406
GLY A 407
HIS A  47
GLU A 417
ILE A 358
 None
 1.33A 5igwA-5gslA:
undetectable		 5igwA-5gslA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0r VP4 PROTEIN

(Cypovirus 1) 		no annotation 5 GLY G 489
TYR G 534
SER G 467
PHE G 471
TYR G 472
 None
 1.35A 5igwA-5h0rG:
undetectable		 5igwA-5h0rG:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8y SULFITE REDUCTASE
[FERREDOXIN],
CHLOROPLASTIC

(Zea mays) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 ILE A 296
GLY A 297
GLU A 384
ARG A 331
ILE A 378
 None
 1.33A 5igwA-5h8yA:
undetectable		 5igwA-5h8yA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i98 FK506-BINDING
PROTEIN 1

(Candida
albicans) 		PF00254
(FKBP_C) 		5 ILE A  60
GLY A  62
ASP A  41
ILE A  28
PHE A  50
 None
 1.31A 5igwA-5i98A:
undetectable		 5igwA-5i98A:
18.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II

(Escherichia
coli) 		PF01636
(APH) 		6 ARG A 237
SER A 276
ILE A 277
PHE A 280
TYR A 289
MET A 292
 None
 0.94A 5igwA-5iguA:
31.4		 5igwA-5iguA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II

(Escherichia
coli) 		PF01636
(APH) 		5 HIS A 202
ILE A 277
PHE A 280
TYR A 289
MET A 292
 None
 1.30A 5igwA-5iguA:
31.4		 5igwA-5iguA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6e FK506-BINDING
PROTEIN 1A

(Aspergillus
fumigatus) 		PF00254
(FKBP_C) 		5 ILE A  57
GLY A  59
ASP A  38
ILE A  25
PHE A  47
 None
 1.25A 5igwA-5j6eA:
undetectable		 5igwA-5j6eA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5x DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA135

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF06883
(RNA_pol_Rpa2_4) 		5 ILE B 104
GLY B 135
ILE B 412
TYR B 409
MET B 461
 None
 1.30A 5igwA-5m5xB:
undetectable		 5igwA-5m5xB:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkm PROTEIN SMG-8

(Caenorhabditis
elegans) 		PF10220
(Smg8_Smg9) 		5 ILE E   3
GLY E  64
GLU E 313
SER E 307
ILE E  22
 None
None
None
EDO  E 505 (-3.0A)
None
 1.40A 5igwA-5nkmE:
undetectable		 5igwA-5nkmE:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE

(Homo sapiens) 		no annotation 5 ILE A 598
GLY A 611
ASP A 645
SER A 627
ILE A 631
 None
 1.21A 5igwA-5nn8A:
undetectable		 5igwA-5nn8A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio rerio;
Escherichia
coli) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		5 GLY A1106
HIS A1113
GLU A1311
ILE A1187
PHE A1296
 A3P  A1401 (-3.2A)
None
None
None
None
 1.41A 5igwA-5t03A:
undetectable		 5igwA-5t03A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4f PUTATIVE
TRANSLATIONAL
INHIBITOR PROTEIN

(Yersinia pestis) 		PF01042
(Ribonuc_L-PSP) 		5 ILE A  98
GLY A  18
TYR A 102
GLU A 126
ARG A  78
 None
None
None
GOL  A 206 (-3.6A)
None
 1.43A 5igwA-5v4fA:
undetectable		 5igwA-5v4fA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veo ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Mus musculus) 		PF01663
(Phosphodiest) 		5 GLY A 323
TYR A 325
ASP A 265
PHE A  68
MET A 348
 None
 1.20A 5igwA-5veoA:
undetectable		 5igwA-5veoA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3w ARYLDIALKYLPHOSPHATA
SE

(Sulfolobus
solfataricus) 		no annotation 5 GLY A  71
ASP A 256
HIS A  24
SER A 171
TYR A  99
 None
FE  A 401 (-2.4A)
FE  A 401 (-3.2A)
None
EDO  A 404 (-4.5A)
 1.17A 5igwA-5w3wA:
undetectable		 5igwA-5w3wA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1

(Saccharomyces
cerevisiae) 		no annotation 5 ILE C 728
GLY C 696
ASP C 722
SER C 716
ILE C 710
 None
 1.40A 5igwA-5x6oC:
5.7		 5igwA-5x6oC:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7l TSRD

(Streptomyces
laurentii) 		no annotation 5 GLY A  46
TYR A  33
ASP A 119
HIS A 117
GLU A 120
 None
None
IPA  A 202 ( 4.8A)
IPA  A 202 (-3.5A)
None
 1.40A 5igwA-5x7lA:
2.4		 5igwA-5x7lA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 5 ILE A 316
GLY A 313
ASP A 285
GLU A 282
ILE A 343
 None
 1.32A 5igwA-5xqoA:
undetectable		 5igwA-5xqoA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E

(Mus musculus) 		no annotation 5 GLY A 700
TYR A 831
ASP A 634
HIS A 835
PHE A 668
 None
 1.44A 5igwA-5yudA:
undetectable		 5igwA-5yudA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8s LOGANIC ACID
O-METHYLTRANSFERASE

(Catharanthus
roseus) 		no annotation 5 GLY A  77
ASP A 361
ILE A 320
TYR A  31
MET A  22
 SAH  A 401 (-3.5A)
None
None
SAH  A 401 (-4.5A)
SAH  A 401 (-3.7A)
 1.15A 5igwA-6c8sA:
undetectable		 5igwA-6c8sA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 ILE H 290
GLY H 287
GLU H 307
ILE H 317
PHE H 283
 None
 1.43A 5igwA-6chsH:
undetectable		 5igwA-6chsH:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE

(Klebsiella
pneumoniae) 		no annotation 5 ILE A  19
GLY A  18
SER A  34
ILE A  63
PHE A  65
 None
ACT  A 503 (-3.4A)
None
None
None
 1.41A 5igwA-6duxA:
undetectable		 5igwA-6duxA:
12.12