SIMILAR PATTERNS OF AMINO ACIDS FOR 5IGV_A_ZITA404_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqb PROTEIN (AUREOLYSIN)

(Staphylococcus
aureus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		5 ALA A 274
SER A 231
ILE A 233
TYR A 217
MET A 214
 None
 1.13A 5igvA-1bqbA:
0.0		 5igvA-1bqbA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II

(Synechocystis
sp. PCC 6803) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A 361
GLY A 259
GLU A 353
SER A 171
ILE A 174
 None
 1.21A 5igvA-1e5mA:
undetectable		 5igvA-1e5mA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1io0 TROPOMODULIN

(Gallus gallus) 		no annotation 5 ILE A 269
GLY A 268
GLU A 284
SER A 230
ILE A 231
 None
 1.23A 5igvA-1io0A:
undetectable		 5igvA-1io0A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jgc BACTERIOFERRITIN

(Rhodobacter
capsulatus) 		PF00210
(Ferritin) 		5 ILE A  79
ASP A  90
HIS A  28
GLU A  94
ILE A  22
 None
None
None
None
HEM  A 201 ( 4.6A)
 1.27A 5igvA-1jgcA:
undetectable		 5igvA-1jgcA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksi COPPER AMINE OXIDASE

(Pisum sativum) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 ILE A 255
GLY A 254
GLU A 394
SER A 619
ILE A 405
 None
 1.25A 5igvA-1ksiA:
0.0		 5igvA-1ksiA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN

(Oligotropha
carboxidovorans) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 GLY C 113
GLU C  66
ALA C  80
ILE C 172
MET C 129
 FAD  C3932 ( 4.9A)
None
None
None
None
 1.23A 5igvA-1n61C:
undetectable		 5igvA-1n61C:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8y PROTOONCOPROTEIN

(Rattus
norvegicus) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 ILE C 414
GLY C 412
TYR C 388
GLU C 327
ALA C 354
 None
 1.19A 5igvA-1n8yC:
undetectable		 5igvA-1n8yC:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuu GALACTOKINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 GLY A 350
HIS A 311
GLU A 330
ILE A 368
TYR A 372
 None
 1.21A 5igvA-1wuuA:
undetectable		 5igvA-1wuuA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xx4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL

(Rattus
norvegicus) 		PF00378
(ECH_1) 		5 ILE A  78
GLY A  43
SER A 131
ILE A 130
MET A 227
 None
 1.04A 5igvA-1xx4A:
undetectable		 5igvA-1xx4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR

(Homo sapiens) 		PF00089
(Trypsin) 		5 ILE A 616
GLY A 619
TYR A 631
ALA A 584
SER A 412
 None
 0.93A 5igvA-1ybwA:
undetectable		 5igvA-1ybwA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE

(Bacillus
thuringiensis) 		PF00753
(Lactamase_B) 		5 GLY A 111
ASP A 191
HIS A 104
ALA A 131
ILE A  73
 None
ZN  A 251 ( 2.4A)
ZN  A 252 (-3.3A)
None
None
 1.26A 5igvA-2a7mA:
undetectable		 5igvA-2a7mA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmo OXYGENASE-ALPHA NBDO

(Comamonas sp.
JS765) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 GLY A 245
TYR A 160
ARG A  35
ALA A 154
ILE A 422
 None
None
EDO  A1444 (-3.8A)
None
None
 1.06A 5igvA-2bmoA:
undetectable		 5igvA-2bmoA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb9 FENGYCIN SYNTHETASE

(Bacillus
subtilis) 		PF00975
(Thioesterase) 		5 GLY A  86
GLU A  58
ALA A 152
ILE A  62
TYR A  65
 None
 0.98A 5igvA-2cb9A:
undetectable		 5igvA-2cb9A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw6 BLL6730 PROTEIN

(Bradyrhizobium
japonicum) 		PF13378
(MR_MLE_C) 		5 ILE A 320
GLY A 339
TYR A 151
ALA A 153
TYR A 302
 None
None
None
TAR  A1001 ( 4.5A)
None
 1.09A 5igvA-2dw6A:
undetectable		 5igvA-2dw6A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Aquifex
aeolicus) 		PF03331
(LpxC) 		5 ILE A  18
GLY A 210
ASP A 242
HIS A  79
ARG A 190
 TUX  A 901 ( 4.9A)
TUX  A 901 ( 3.9A)
ZN  A 601 ( 2.2A)
ZN  A 601 ( 3.3A)
None
 1.12A 5igvA-2go4A:
undetectable		 5igvA-2go4A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 ILE A 230
GLU A 264
ARG A 291
ALA A 328
ILE A 259
 None
 1.15A 5igvA-2jjdA:
2.0		 5igvA-2jjdA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwh CARBOHYDRATE KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		5 TYR A 113
ASP A  13
HIS A  11
GLU A  35
ARG A  60
 None
None
CL  A 403 ( 4.9A)
None
None
 0.98A 5igvA-2nwhA:
undetectable		 5igvA-2nwhA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4v PORIN P

(Pseudomonas
aeruginosa) 		PF07396
(Porin_O_P) 		5 GLY A 362
HIS A 365
ARG A 337
ALA A 299
TYR A  46
 None
 1.15A 5igvA-2o4vA:
undetectable		 5igvA-2o4vA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okj GLUTAMATE
DECARBOXYLASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 GLY A 246
ASP A 373
HIS A 371
ALA A 263
ILE A 254
 None
LLP  A 405 ( 2.7A)
None
None
None
 1.23A 5igvA-2okjA:
undetectable		 5igvA-2okjA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb0 ACETYLORNITHINE/SUCC
INYLDIAMINOPIMELATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00202
(Aminotran_3) 		5 ILE A 311
GLY A 236
GLU A 385
ALA A  52
ILE A 301
 None
 1.25A 5igvA-2pb0A:
undetectable		 5igvA-2pb0A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE

(Thermus
thermophilus) 		PF00701
(DHDPS) 		5 ILE A 151
GLY A 150
TYR A 164
ASP A 133
TYR A 112
 None
 1.26A 5igvA-2pcqA:
undetectable		 5igvA-2pcqA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwh SUCROSE ISOMERASE

([Pseudomonas]
mesoacidophila) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 GLY A 253
GLU A 238
ALA A 249
ILE A 102
TYR A 205
 None
 1.25A 5igvA-2pwhA:
3.5		 5igvA-2pwhA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16918
(PknG_TPR)
PF16919
(PknG_rubred) 		5 GLY A 584
TYR A 552
GLU A 448
ALA A 555
SER A 604
 None
 1.08A 5igvA-2pziA:
6.6		 5igvA-2pziA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 5 GLY A 210
TYR A 175
ASP A 153
ALA A 179
TYR A  29
 None
None
CA  A 621 (-2.9A)
None
None
 1.21A 5igvA-2quaA:
undetectable		 5igvA-2quaA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qya UNCHARACTERIZED
CONSERVED PROTEIN

(Methanopyrus
kandleri) 		PF04242
(DUF424) 		5 ILE A  38
GLY A  26
TYR A  43
GLU A  96
ALA A  18
 None
 1.17A 5igvA-2qyaA:
undetectable		 5igvA-2qyaA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr2 DIHYDROPYRIMIDINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 GLY A  94
TYR A 448
ALA A 450
SER A 415
ILE A 414
 None
 1.07A 5igvA-2vr2A:
undetectable		 5igvA-2vr2A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsg VARIANT SURFACE
GLYCOPROTEIN ILTAT
1.24

(Trypanosoma
brucei) 		PF00913
(Trypan_glycop) 		5 ILE A 107
GLY A 106
GLU A   8
ALA A  18
SER A 167
 None
 1.26A 5igvA-2vsgA:
undetectable		 5igvA-2vsgA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE

(Lactobacillus
delbrueckii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 GLY A  80
ASP A 261
HIS A 298
TYR A 102
MET A 310
 None
 1.19A 5igvA-2yq4A:
undetectable		 5igvA-2yq4A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zux YESW PROTEIN

(Bacillus
subtilis) 		no annotation 5 ILE A 493
GLY A 492
ALA A 530
ILE A 588
TYR A 584
 None
 1.20A 5igvA-2zuxA:
undetectable		 5igvA-2zuxA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		5 ILE A 420
TYR A 418
HIS A 491
ALA A 432
ILE A 390
 None
 1.22A 5igvA-3a5iA:
undetectable		 5igvA-3a5iA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahx BETA-GLUCOSIDASE A

(Clostridium
cellulovorans) 		PF00232
(Glyco_hydro_1) 		5 ILE A 184
TYR A 175
GLU A  32
ALA A 170
SER A  39
 None
 1.23A 5igvA-3ahxA:
undetectable		 5igvA-3ahxA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahx BETA-GLUCOSIDASE A

(Clostridium
cellulovorans) 		PF00232
(Glyco_hydro_1) 		5 ILE A 398
GLY A 354
TYR A 396
GLU A 438
ALA A 383
 None
 1.24A 5igvA-3ahxA:
undetectable		 5igvA-3ahxA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8u PURR TRANSCRIPTIONAL
REGULATOR

(Vibrio
parahaemolyticus) 		PF13377
(Peripla_BP_3) 		5 ILE A 193
GLY A 238
GLU A 284
ALA A 251
ILE A 261
 None
 1.05A 5igvA-3d8uA:
undetectable		 5igvA-3d8uA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djd FRUCTOSYL AMINE:
OXYGEN
OXIDOREDUCTASE

(Aspergillus
fumigatus) 		PF01266
(DAO) 		5 GLY A  48
HIS A 159
GLU A 267
ALA A 166
ILE A  55
 FAD  A 500 (-3.9A)
None
None
None
None
 1.20A 5igvA-3djdA:
undetectable		 5igvA-3djdA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eby BETA SUBUNIT OF A
PUTATIVE
AROMATIC-RING-HYDROX
YLATING DIOXYGENASE

(Novosphingobium
aromaticivorans) 		PF00866
(Ring_hydroxyl_B) 		5 ILE A 162
TYR A 129
HIS A  89
ALA A 108
ILE A 123
 None
 1.09A 5igvA-3ebyA:
3.4		 5igvA-3ebyA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eix HTSA PROTEIN

(Staphylococcus
aureus) 		PF01497
(Peripla_BP_2) 		5 ILE A 120
GLU A  44
ALA A  79
SER A 156
ILE A 160
 None
 1.12A 5igvA-3eixA:
undetectable		 5igvA-3eixA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flu DIHYDRODIPICOLINATE
SYNTHASE

(Neisseria
meningitidis) 		PF00701
(DHDPS) 		5 GLY A  46
ALA A 209
SER A 185
ILE A 203
TYR A 133
 None
None
None
SO4  A 294 (-4.6A)
SO4  A 294 ( 4.7A)
 1.14A 5igvA-3fluA:
undetectable		 5igvA-3fluA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbj KIF13B PROTEIN

(Homo sapiens) 		PF00225
(Kinesin) 		5 GLY A 103
TYR A 346
ALA A 350
SER A 250
MET A 113
 None
 1.22A 5igvA-3gbjA:
undetectable		 5igvA-3gbjA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE

(Rauvolfia
serpentina) 		PF00561
(Abhydrolase_1) 		5 GLY A  89
ALA A  42
SER A 105
ILE A 104
MET A  97
 None
 1.03A 5igvA-3gzjA:
undetectable		 5igvA-3gzjA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE

(Rauvolfia
serpentina) 		PF00561
(Abhydrolase_1) 		5 GLY A  90
ALA A  42
SER A 105
ILE A 104
MET A  97
 None
 1.22A 5igvA-3gzjA:
undetectable		 5igvA-3gzjA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hh8 METAL ABC
TRANSPORTER
SUBSTRATE-BINDING
LIPOPROTEIN

(Streptococcus
pyogenes) 		PF01297
(ZnuA) 		5 ASP A 280
HIS A  67
ALA A  98
ILE A  42
TYR A 150
 FE  A 401 (-2.1A)
FE  A 401 (-3.3A)
None
None
None
 1.11A 5igvA-3hh8A:
undetectable		 5igvA-3hh8A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hh8 METAL ABC
TRANSPORTER
SUBSTRATE-BINDING
LIPOPROTEIN

(Streptococcus
pyogenes) 		PF01297
(ZnuA) 		5 ASP A 280
HIS A  67
ALA A  98
SER A  40
ILE A  42
 FE  A 401 (-2.1A)
FE  A 401 (-3.3A)
None
None
None
 1.27A 5igvA-3hh8A:
undetectable		 5igvA-3hh8A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ir9 PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1

(Methanosarcina
mazei) 		PF03465
(eRF1_3) 		5 ILE A 405
GLY A 299
ASP A 369
GLU A 324
ALA A 378
 None
 1.23A 5igvA-3ir9A:
undetectable		 5igvA-3ir9A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv7 ALCOHOL
DEHYDROGENASE IV

(Corynebacterium
glutamicum) 		PF00465
(Fe-ADH) 		5 ILE A 100
GLY A  96
GLU A 149
ALA A 229
ILE A 152
 None
 1.19A 5igvA-3iv7A:
undetectable		 5igvA-3iv7A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE

(Drosophila
melanogaster) 		PF00282
(Pyridoxal_deC) 		5 ILE A 144
GLU A 113
ALA A  91
SER A 108
ILE A 106
 None
 1.10A 5igvA-3k40A:
undetectable		 5igvA-3k40A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE

(Shewanella
frigidimarina) 		PF04952
(AstE_AspA) 		5 GLY A 175
GLU A 257
ALA A  41
SER A 196
ILE A 197
 UNL  A 373 ( 3.5A)
None
None
None
None
 1.12A 5igvA-3lwuA:
undetectable		 5igvA-3lwuA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8u HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		5 ILE A 288
GLY A 428
HIS A 500
ILE A 318
MET A 388
 None
GDS  A   1 (-3.6A)
None
None
None
 1.07A 5igvA-3m8uA:
undetectable		 5igvA-3m8uA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mil ISOAMYL
ACETATE-HYDROLYZING
ESTERASE

(Saccharomyces
cerevisiae) 		PF13472
(Lipase_GDSL_2) 		5 GLY A 195
TYR A  30
HIS A 200
ALA A  34
ILE A 119
 None
 1.26A 5igvA-3milA:
undetectable		 5igvA-3milA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n4t APH(2'')-ID

(Enterococcus
casseliflavus) 		PF01636
(APH) 		5 ILE A 277
TYR A 278
GLU A 148
ILE A 180
TYR A 177
 None
 1.14A 5igvA-3n4tA:
22.0		 5igvA-3n4tA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6b CELL DIVISION
CONTROL PROTEIN 53
DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1

(Saccharomyces
cerevisiae) 		PF03556
(Cullin_binding)
PF10557
(Cullin_Nedd8) 		5 ILE B 793
TYR B 811
HIS B 767
GLU A 250
ILE A 257
 None
 1.06A 5igvA-3o6bB:
undetectable		 5igvA-3o6bB:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Legionella
pneumophila) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLY A 194
ASP A 451
HIS A 449
ALA A 128
SER A 458
 None
None
GOL  A 522 (-4.4A)
None
None
 1.17A 5igvA-3pfeA:
undetectable		 5igvA-3pfeA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Francisella
tularensis) 		PF00342
(PGI) 		5 ALA A 213
SER A 235
ILE A 234
TYR A 252
MET A 270
 None
 1.14A 5igvA-3q88A:
undetectable		 5igvA-3q88A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qom 6-PHOSPHO-BETA-GLUCO
SIDASE

(Lactobacillus
plantarum) 		PF00232
(Glyco_hydro_1) 		5 ILE A 238
GLY A 229
ALA A 221
SER A  91
ILE A  92
 None
 1.17A 5igvA-3qomA:
undetectable		 5igvA-3qomA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thw DNA MISMATCH REPAIR
PROTEIN MSH3

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05192
(MutS_III) 		5 ILE B 666
HIS B 818
ALA B 820
SER B 656
ILE B 654
 None
 1.10A 5igvA-3thwB:
undetectable		 5igvA-3thwB:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1

(Bos taurus) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF08282
(Hydrolase_3)
PF13246
(Cation_ATPase) 		5 GLU A 714
ARG A 750
ALA A 751
SER A 346
ILE A 618
 None
 1.19A 5igvA-3tlmA:
undetectable		 5igvA-3tlmA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Bradyrhizobium
sp. ORS 278) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 HIS A 233
GLU A 222
ARG A 237
ALA A 235
ILE A 293
 None
CA  A 361 (-3.3A)
None
None
None
 1.18A 5igvA-3toyA:
undetectable		 5igvA-3toyA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uet ALPHA-1,3/4-FUCOSIDA
SE

(Bifidobacterium
longum) 		PF01120
(Alpha_L_fucos) 		5 ILE A  80
GLY A 129
TYR A  32
GLU A 237
ILE A 204
 None
None
None
GAL  A 504 (-3.5A)
None
 1.19A 5igvA-3uetA:
undetectable		 5igvA-3uetA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epa PESTICIN RECEPTOR

(Yersinia pestis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 GLY A 116
TYR A 433
ALA A 453
SER A  95
TYR A  87
 None
 1.22A 5igvA-4epaA:
undetectable		 5igvA-4epaA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eq5 DNA LIGASE

(Thermococcus
sibiricus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 GLY A  59
ALA A 186
SER A  12
ILE A 125
TYR A  14
 None
 1.23A 5igvA-4eq5A:
undetectable		 5igvA-4eq5A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 TYR A 539
GLU A 420
SER A 511
ILE A 510
MET A 482
 None
None
0SB  A 701 (-3.2A)
None
None
 1.26A 5igvA-4f4pA:
8.0		 5igvA-4f4pA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 GLY A  47
ALA A 191
SER A  17
ILE A  16
TYR A   7
 None
 1.24A 5igvA-4fn7A:
undetectable		 5igvA-4fn7A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Ochrobactrum
sp. T63) 		PF00561
(Abhydrolase_1) 		5 ILE A  30
GLY A 104
ARG A 114
ALA A  83
ILE A 112
 None
 1.26A 5igvA-4g8dA:
undetectable		 5igvA-4g8dA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
WBC-3) 		PF00171
(Aldedh) 		5 ILE A 336
GLY A 350
GLU A 381
ALA A 371
ILE A 273
 None
None
NAD  A 601 (-2.6A)
None
None
 1.21A 5igvA-4go4A:
undetectable		 5igvA-4go4A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpn 6-PHOSPHO-BETA-D-GLU
COSIDASE

(Streptococcus
mutans) 		PF00232
(Glyco_hydro_1) 		5 ILE A 234
GLY A 225
ALA A 217
SER A  87
ILE A  88
 None
 1.21A 5igvA-4gpnA:
undetectable		 5igvA-4gpnA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvt POST-PROLINE
CLEAVING ENZYME

(Rickettsia
typhi) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 ILE A 472
GLY A 471
SER A 417
ILE A 418
TYR A 447
 None
 1.26A 5igvA-4hvtA:
2.4		 5igvA-4hvtA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN

(Mycobacterium
tuberculosis) 		PF02126
(PTE) 		5 GLY A  72
ASP A 264
HIS A  24
ALA A  94
TYR A 100
 None
ZN  A 401 (-2.4A)
ZN  A 401 (-3.2A)
KCX  A 145 ( 4.6A)
None
 1.22A 5igvA-4if2A:
undetectable		 5igvA-4if2A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4klz GTP-BINDING PROTEIN
RIT1

(Homo sapiens) 		PF00071
(Ras) 		5 ILE A  42
ASP A 172
ALA A  69
ILE A  97
MET A  26
 None
 1.16A 5igvA-4klzA:
undetectable		 5igvA-4klzA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		5 ILE A 214
GLY A 213
ALA A 221
SER A 102
ILE A 149
 None
None
None
ANP  A 401 (-3.6A)
None
 1.09A 5igvA-4m69A:
5.3		 5igvA-4m69A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwz FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Caldalkalibacillus
thermarum) 		PF07992
(Pyr_redox_2) 		5 ILE A 387
TYR A 383
HIS A  42
ALA A 316
ILE A   8
 None
None
None
FAD  A 601 (-3.6A)
None
 1.18A 5igvA-4nwzA:
undetectable		 5igvA-4nwzA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o48 UNCHARACTERIZED
PROTEIN

(Cavia porcellus) 		PF01112
(Asparaginase_2) 		5 ILE A 213
GLY A 214
ALA A 252
ILE A 203
MET A  82
 None
 1.22A 5igvA-4o48A:
undetectable		 5igvA-4o48A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus) 		PF01546
(Peptidase_M20) 		5 GLY A  18
ALA A  55
SER A   4
ILE A   5
MET A  10
 None
 1.19A 5igvA-4q7aA:
undetectable		 5igvA-4q7aA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyj ALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 ILE A 356
GLY A 370
GLU A 400
ALA A 364
ILE A 293
 None
 1.17A 5igvA-4qyjA:
undetectable		 5igvA-4qyjA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdy PARATHION HYDROLASE

(Vulcanisaeta
moutnovskia) 		PF02126
(PTE) 		5 ILE A  73
GLY A  72
ASP A 257
HIS A  25
TYR A 100
 None
None
CO  A 401 ( 2.5A)
CO  A 401 ( 3.3A)
GOL  A 406 (-3.8A)
 1.12A 5igvA-4rdyA:
undetectable		 5igvA-4rdyA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tm5 D-AMINO ACID
AMINOTRANSFERASE

(Burkholderia
thailandensis) 		PF01063
(Aminotran_4) 		5 GLY A 223
GLU A 235
ALA A 242
ILE A 265
TYR A 292
 LLP  A 165 ( 3.4A)
None
None
None
None
 1.26A 5igvA-4tm5A:
undetectable		 5igvA-4tm5A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xf5 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Chromohalobacter
salexigens) 		PF03480
(DctP) 		5 ILE A 213
GLY A 212
ASP A 155
SER A 239
ILE A 238
 None
None
2A1  A 403 (-2.8A)
None
None
 1.00A 5igvA-4xf5A:
undetectable		 5igvA-4xf5A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Homo sapiens) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
PF09336
(Vps4_C) 		5 ILE A 371
GLY A 370
HIS A 404
SER A 541
ILE A 540
 None
 1.22A 5igvA-5c1bA:
undetectable		 5igvA-5c1bA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6g AGR133CP
SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii) 		PF10345
(Cohesin_load)
no annotation 		5 ILE B  11
GLY B   6
GLU A 408
ARG A 616
ALA A 619
 None
 0.88A 5igvA-5c6gB:
undetectable		 5igvA-5c6gB:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 GLY A 358
TYR A 251
HIS A 480
ALA A 239
ILE A 410
 None
 1.13A 5igvA-5clwA:
2.4		 5igvA-5clwA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqp EDTA MONOOXYGENASE

(EDTA-degrading
bacterium BNC1) 		PF00296
(Bac_luciferase) 		5 ILE A  89
GLY A  90
TYR A 413
GLU A 393
ILE A 383
 None
 1.26A 5igvA-5dqpA:
undetectable		 5igvA-5dqpA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evj ARSENITE
METHYLTRANSFERASE

(Chlamydomonas
reinhardtii) 		PF13847
(Methyltransf_31) 		5 ILE A  82
GLY A  81
ASP A  89
ALA A  59
SER A 198
 None
 1.25A 5igvA-5evjA:
undetectable		 5igvA-5evjA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8v AMINOTRANSFERASE,
CLASS V FAMILY
PROTEIN

(Trichomonas
vaginalis) 		PF00266
(Aminotran_5) 		5 ILE A 175
GLY A 194
GLU A 111
ALA A 148
TYR A 233
 None
 1.20A 5igvA-5f8vA:
undetectable		 5igvA-5f8vA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hk8 PROBABLE
PHEOPHORBIDASE

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		5 GLY A  89
ASP A 211
HIS A 239
ILE A 206
TYR A 205
 None
 1.19A 5igvA-5hk8A:
undetectable		 5igvA-5hk8A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hk8 PROBABLE
PHEOPHORBIDASE

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		5 GLY A  90
ASP A 211
HIS A 239
ILE A 206
TYR A 205
 None
 1.13A 5igvA-5hk8A:
undetectable		 5igvA-5hk8A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hoe HYDROLASE

(Sinorhizobium
meliloti) 		PF13472
(Lipase_GDSL_2) 		5 ILE A 188
GLY A 185
ALA A 145
SER A  13
MET A  92
 None
None
None
PO4  A 301 (-2.5A)
None
 1.25A 5igvA-5hoeA:
undetectable		 5igvA-5hoeA:
21.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II

(Escherichia
coli) 		PF01636
(APH) 		6 ARG A 237
ALA A 238
SER A 276
ILE A 277
TYR A 289
MET A 292
 None
 0.89A 5igvA-5iguA:
30.9		 5igvA-5iguA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II

(Escherichia
coli) 		PF01636
(APH) 		5 ASP A 200
GLU A 222
ARG A 237
ALA A 238
SER A 276
 None
 0.74A 5igvA-5iguA:
30.9		 5igvA-5iguA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 ILE A 357
GLY A 371
GLU A 401
ALA A 365
ILE A 294
 None
None
NAD  A 700 (-2.9A)
None
None
 1.00A 5igvA-5iuwA:
undetectable		 5igvA-5iuwA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcomitans) 		no annotation 5 ILE A 215
GLY A  45
ASP A 223
SER A  29
ILE A   6
 None
ATP  A 701 (-3.2A)
None
None
None
 1.19A 5igvA-5lj6A:
undetectable		 5igvA-5lj6A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mso CARBOXYLIC ACID
REDUCTASE

(Mycobacterium
marinum) 		PF07993
(NAD_binding_4) 		5 GLY A 923
TYR A 956
ASP A1000
ALA A 882
MET A1062
 None
NAP  A1201 (-4.7A)
None
NAP  A1201 (-3.6A)
None
 1.05A 5igvA-5msoA:
undetectable		 5igvA-5msoA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT A
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D

(Methanothermococcus
thermolithotrophicus) 		PF02662
(FlpD)
PF07992
(Pyr_redox_2)
PF13187
(Fer4_9) 		5 ILE D  37
GLY D  10
ASP D  22
HIS A 102
ILE D 107
 None
 1.19A 5igvA-5odrD:
undetectable		 5igvA-5odrD:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t67 SUGAR 3-C-METHYL
TRANSFERASE

(Actinomadura
kijaniata) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		5 GLY A  82
TYR A  78
HIS A 254
ALA A 327
ILE A 390
 None
JHZ  A 503 (-3.2A)
JHZ  A 503 (-3.8A)
JHZ  A 503 (-3.5A)
JHZ  A 503 (-4.6A)
 1.25A 5igvA-5t67A:
undetectable		 5igvA-5t67A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3w ARYLDIALKYLPHOSPHATA
SE

(Sulfolobus
solfataricus) 		no annotation 5 GLY A  71
ASP A 256
HIS A  24
SER A 171
TYR A  99
 None
FE  A 401 (-2.4A)
FE  A 401 (-3.2A)
None
EDO  A 404 (-4.5A)
 1.23A 5igvA-5w3wA:
undetectable		 5igvA-5w3wA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES

(Corynebacterium
glutamicum) 		PF01053
(Cys_Met_Meta_PP) 		5 ILE A 206
GLY A 207
ASP A 179
GLU A 150
ALA A  78
 None
None
PLP  A 401 (-3.1A)
PLP  A 401 ( 3.8A)
None
 1.20A 5igvA-5x5hA:
undetectable		 5igvA-5x5hA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbp 3NT OXYGENASE ALPHA
SUBUNIT

(Diaphorobacter
sp. DS2) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 GLY A 245
TYR A 160
ARG A  35
ALA A 154
ILE A 422
 None
 1.19A 5igvA-5xbpA:
undetectable		 5igvA-5xbpA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xii PROLYL-TRNA
SYNTHETASE (PRORS)

(Toxoplasma
gondii) 		no annotation 5 ILE A 720
GLY A 719
GLU A 680
ILE A 704
TYR A 702
 None
 1.22A 5igvA-5xiiA:
undetectable		 5igvA-5xiiA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b67 PROTEIN PHOSPHATASE
1A

(Homo sapiens) 		no annotation 5 GLY A 149
HIS A 222
GLU A 225
SER A 135
ILE A 134
 None
 1.26A 5igvA-6b67A:
undetectable		 5igvA-6b67A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c96 TWO PORE CALCIUM
CHANNEL PROTEIN 1

(Mus musculus) 		no annotation 5 ILE A 710
GLY A 709
ALA A 408
SER A 770
TYR A 697
 None
 1.21A 5igvA-6c96A:
undetectable		 5igvA-6c96A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ch3 FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Salmonella
enterica) 		no annotation 5 ILE A 420
TYR A 418
HIS A 491
ALA A 432
ILE A 390
 None
 1.26A 5igvA-6ch3A:
undetectable		 5igvA-6ch3A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dhi -

(-) 		no annotation 5 GLY A 210
GLU A 435
ALA A 445
ILE A 179
TYR A 162
 None
None
None
None
SNN  A 164 ( 4.6A)
 1.21A 5igvA-6dhiA:
undetectable		 5igvA-6dhiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fay ODZ3 PROTEIN

(Mus musculus) 		no annotation 5 GLY A2316
GLU A2132
ALA A2336
ILE A2135
TYR A2116
 None
 1.08A 5igvA-6fayA:
undetectable		 5igvA-6fayA:
13.76