SIMILAR PATTERNS OF AMINO ACIDS FOR 5IGT_A_ERYA402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (ALPHA
SUBUNIT)

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		5 ILE A 154
VAL A 179
GLU A 385
ALA A 195
VAL A 192
 None
 1.00A 5igtA-1a6dA:
0.0		 5igtA-1a6dA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		6 PRO A 489
VAL A 326
ALA A 412
ALA A 415
LEU A 524
GLY A 523
 None
 1.48A 5igtA-1c2oA:
0.0		 5igtA-1c2oA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8o ICE INHIBITOR

(Cowpox virus) 		PF00079
(Serpin) 		5 ILE A 235
PRO A 236
GLY A 242
THR A 282
TYR A 283
 None
 0.90A 5igtA-1c8oA:
0.0		 5igtA-1c8oA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1civ NADP-MALATE
DEHYDROGENASE

(Flaveria
bidentis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 HIS A  57
ALA A  51
VAL A  47
LEU A  88
GLY A  90
 None
NAP  A 386 (-3.4A)
None
None
None
 1.05A 5igtA-1civA:
0.0		 5igtA-1civA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ILE B 520
VAL B 260
ALA B 221
GLY B 277
TYR B 275
 None
 1.03A 5igtA-1ffvB:
0.0		 5igtA-1ffvB:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF00490
(ALAD) 		5 ILE A  80
PRO A  81
ALA A 312
GLY A 262
TYR A 283
 None
None
None
None
LAF  A1337 (-3.5A)
 1.04A 5igtA-1gzgA:
0.0		 5igtA-1gzgA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibj CYSTATHIONINE
BETA-LYASE

(Arabidopsis
thaliana) 		PF01053
(Cys_Met_Meta_PP) 		5 HIS A 274
ALA A 159
ALA A 160
VAL A 164
GLY A 312
 None
 0.82A 5igtA-1ibjA:
0.0		 5igtA-1ibjA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipf TROPINONE
REDUCTASE-II

(Datura
stramonium) 		PF13561
(adh_short_C2) 		5 ILE A  21
VAL A  26
ALA A  12
LEU A  88
GLY A 139
 NDP  A 261 (-4.1A)
None
None
None
None
 0.98A 5igtA-1ipfA:
0.0		 5igtA-1ipfA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnz SPO0B-ASSOCIATED
GTP-BINDING PROTEIN

(Bacillus
subtilis) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		6 VAL A 241
HIS A 242
GLU A 264
VAL A 161
LEU A 216
GLY A 215
 None
 1.48A 5igtA-1lnzA:
0.0		 5igtA-1lnzA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw5 MODIFICATION
METHYLASE RSRI

(Rhodobacter
sphaeroides) 		PF01555
(N6_N4_Mtase) 		5 PRO A 204
LEU A  61
GLY A 100
THR A  99
TYR A 168
 None
 1.06A 5igtA-1nw5A:
undetectable		 5igtA-1nw5A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Rattus
norvegicus) 		PF01593
(Amino_oxidase) 		5 ILE A 161
VAL A 189
HIS A 187
ALA A 302
VAL A 182
 None
 0.96A 5igtA-1o5wA:
undetectable		 5igtA-1o5wA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1

(Sus scrofa) 		PF01909
(NTP_transf_2)
PF10421
(OAS1_C) 		6 ILE A  15
VAL A 211
ALA A 323
VAL A 258
LEU A 327
GLY A 328
 None
 1.40A 5igtA-1px5A:
undetectable		 5igtA-1px5A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3t CYTIDYLATE KINASE

(Streptococcus
pneumoniae) 		PF02224
(Cytidylate_kin) 		5 VAL A 121
GLU A 131
ALA A  53
ALA A  54
GLY A  95
 None
 0.87A 5igtA-1q3tA:
undetectable		 5igtA-1q3tA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgc PROTEIN (VIRUS
CAPSID PROTEIN VP1)
PROTEIN (VIRUS
CAPSID PROTEIN VP2)

(Foot-and-mouth
disease virus;
Foot-and-mouth
disease virus) 		PF00073
(Rhv)
PF00073
(Rhv) 		5 ILE 2 197
VAL 2 109
VAL 2 123
GLY 1   5
THR 1   4
 None
 1.03A 5igtA-1qgc2:
undetectable		 5igtA-1qgc2:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxy METHIONYL
AMINOPEPTIDASE

(Staphylococcus
aureus) 		PF00557
(Peptidase_M24) 		5 ILE A 251
ALA A  55
ALA A  96
VAL A  94
LEU A 174
 None
M2C  A3001 ( 4.8A)
None
None
M2C  A3001 (-4.5A)
 1.02A 5igtA-1qxyA:
undetectable		 5igtA-1qxyA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qy9 HYPOTHETICAL PROTEIN
YDDE

(Escherichia
coli) 		PF02567
(PhzC-PhzF) 		5 ILE A  60
VAL A  82
GLU A 108
ALA A 285
VAL A   8
 None
 0.94A 5igtA-1qy9A:
0.5		 5igtA-1qy9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqb TRANSCARBOXYLASE 5S
SUBUNIT

(Propionibacterium
freudenreichii) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		6 ILE A  16
ALA A  24
VAL A  20
LEU A  28
GLY A 248
THR A 219
 None
 1.44A 5igtA-1rqbA:
undetectable		 5igtA-1rqbA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvk ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 308
HIS A 309
ALA A 313
VAL A 318
LEU A 367
 None
 0.96A 5igtA-1rvkA:
undetectable		 5igtA-1rvkA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si1 IRON BINDING PROTEIN
FBPA

(Mannheimia
haemolytica) 		PF13343
(SBP_bac_6) 		6 ILE A 194
ALA A 303
ALA A 304
VAL A 308
GLY A 155
TYR A 154
 None
 0.84A 5igtA-1si1A:
undetectable		 5igtA-1si1A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32) 		PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ) 		6 ILE A 519
VAL A 367
ALA A 350
ALA A 351
VAL A 439
GLY A 465
 None
 1.43A 5igtA-1t1eA:
undetectable		 5igtA-1t1eA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txk GLUCANS BIOSYNTHESIS
PROTEIN G

(Escherichia
coli) 		PF04349
(MdoG) 		5 PRO A 290
GLU A 456
VAL A 429
GLY A 410
THR A 424
 None
 0.90A 5igtA-1txkA:
0.7		 5igtA-1txkA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN

(Aquifex
aeolicus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ILE A  51
VAL A  29
ALA A  74
VAL A  72
GLY A  98
 None
 0.97A 5igtA-1ulzA:
undetectable		 5igtA-1ulzA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfw PROTEIN (FUSION
PROTEIN CONSISTING
OF KINESIN-LIKE
PROTEIN KIF1A,
KINESIN HEAVY CHAIN
ISOFORM 5C AND A HIS
TAG

(Mus musculus) 		PF00225
(Kinesin) 		5 ILE A 354
VAL A   8
ALA A 330
ALA A 329
GLY A 251
 None
None
None
None
ANP  A 500 (-3.4A)
 1.00A 5igtA-1vfwA:
undetectable		 5igtA-1vfwA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vma CELL DIVISION
PROTEIN FTSY

(Thermotoga
maritima) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		6 ILE A 207
PRO A  92
ALA A 127
ALA A 126
VAL A 124
LEU A 139
 None
 1.38A 5igtA-1vmaA:
undetectable		 5igtA-1vmaA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfd DIPEPTIDYL
AMINOPEPTIDASE-LIKE
PROTEIN 6

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 VAL A 650
HIS A 653
GLU A 845
VAL A 657
GLY A 736
 None
 1.05A 5igtA-1xfdA:
undetectable		 5igtA-1xfdA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 349
HIS A 329
ALA A 432
ALA A 433
GLY A 417
 None
FAD  A4750 (-4.3A)
None
None
None
 0.93A 5igtA-1zy8A:
undetectable		 5igtA-1zy8A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anp LEUCYL
AMINOPEPTIDASE

(Vibrio
proteolyticus) 		PF04389
(Peptidase_M28) 		5 GLU A 245
ALA A 123
ALA A 124
VAL A 128
GLY A 269
 None
 0.88A 5igtA-2anpA:
undetectable		 5igtA-2anpA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ap9 ACETYLGLUTAMATE
KINASE

(Mycobacterium
tuberculosis) 		PF00696
(AA_kinase) 		5 ILE A 176
PRO A 177
VAL A  32
GLU A 282
ALA A 260
 None
 0.99A 5igtA-2ap9A:
undetectable		 5igtA-2ap9A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7i PUTATIVE LIPOATE
PROTEIN LIGASE

(Thermoplasma
acidophilum) 		PF03099
(BPL_LplA_LipB) 		5 VAL A  57
ALA A  78
VAL A  45
GLY A  75
TYR A  49
 None
 0.88A 5igtA-2c7iA:
undetectable		 5igtA-2c7iA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		6 ILE A 149
VAL A 140
GLU A 110
ALA A 274
VAL A 269
LEU A 281
 None
 1.30A 5igtA-2gz3A:
undetectable		 5igtA-2gz3A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hr2 HYPOTHETICAL PROTEIN

(Chlorobaculum
tepidum) 		PF12968
(DUF3856) 		6 VAL A 127
ALA A 120
ALA A 108
VAL A 104
LEU A 111
GLY A 113
 None
 1.44A 5igtA-2hr2A:
undetectable		 5igtA-2hr2A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m5y PUTATIVE TUBERCULIN
RELATED PEPTIDE

(Mycobacterium
tuberculosis) 		PF13399
(LytR_C) 		5 VAL A 118
GLU A 108
ALA A  91
VAL A  94
GLY A  86
 None
 0.99A 5igtA-2m5yA:
undetectable		 5igtA-2m5yA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mki CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 4

(Homo sapiens) 		PF16367
(RRM_7) 		5 VAL A 250
ALA A 230
ALA A 231
VAL A 237
GLY A 199
 None
 1.04A 5igtA-2mkiA:
undetectable		 5igtA-2mkiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN

(Haemophilus
influenzae) 		PF01547
(SBP_bac_1) 		6 GLU A 144
ALA A 285
ALA A 223
VAL A 216
LEU A 283
TYR A 195
 None
 1.49A 5igtA-2o69A:
undetectable		 5igtA-2o69A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE

(Staphylococcus
aureus) 		PF13378
(MR_MLE_C) 		5 ILE A  34
VAL A 104
ALA A  85
ALA A  86
VAL A  90
 None
 1.00A 5igtA-2olaA:
undetectable		 5igtA-2olaA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ovl PUTATIVE RACEMASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 109
VAL A  36
ALA A  61
VAL A  64
GLY A  56
 None
 1.02A 5igtA-2ovlA:
undetectable		 5igtA-2ovlA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Vibrio cholerae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 ILE A 107
VAL A  93
ALA A   9
ALA A  71
GLY A  12
 None
 1.01A 5igtA-2qz9A:
undetectable		 5igtA-2qz9A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x98 ALKALINE PHOSPHATASE

(Halobacterium
salinarum) 		PF00245
(Alk_phosphatase) 		6 VAL A 461
GLU A 151
ALA A  52
VAL A 342
THR A 160
TYR A 158
 None
None
None
None
None
MG  A1481 (-4.7A)
 1.37A 5igtA-2x98A:
undetectable		 5igtA-2x98A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ILE A 214
VAL A 157
ALA A 290
VAL A 309
GLY A 316
 None
 1.02A 5igtA-2xf8A:
1.3		 5igtA-2xf8A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CYTOCHROME C OXIDASE
SUBUNIT 2

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3)
PF00034
(Cytochrom_C)
PF00116
(COX2)
PF02790
(COX2_TM) 		5 ILE B 161
ALA A 214
ALA A 215
VAL A 219
GLY A 638
 None
 0.71A 5igtA-2yevB:
undetectable		 5igtA-2yevB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CYTOCHROME C OXIDASE
SUBUNIT 2

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3)
PF00034
(Cytochrom_C)
PF00116
(COX2)
PF02790
(COX2_TM) 		5 ILE B 161
ALA A 214
ALA A 215
VAL A 219
TYR A 641
 None
 0.73A 5igtA-2yevB:
undetectable		 5igtA-2yevB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvl HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF08704
(GCD14) 		6 ILE A  75
GLU A 211
ALA A 184
ALA A 161
VAL A  95
LEU A 180
 SAM  A 601 (-4.1A)
None
None
None
None
None
 1.34A 5igtA-2yvlA:
undetectable		 5igtA-2yvlA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 ILE A 161
VAL A 189
HIS A 187
ALA A 302
VAL A 182
 None
 0.99A 5igtA-2z5xA:
undetectable		 5igtA-2z5xA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8l FTSZ-LIKE PROTEIN OF
UNKNOWN FUNCTION

(Nostoc
punctiforme) 		PF09585
(Lin0512_fam) 		5 GLU A  65
ALA A  24
ALA A  25
VAL A  29
GLY A  89
 None
 0.81A 5igtA-3c8lA:
undetectable		 5igtA-3c8lA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cer POSSIBLE
EXOPOLYPHOSPHATASE-L
IKE PROTEIN

(Bifidobacterium
longum) 		PF02541
(Ppx-GppA) 		5 PRO A 197
VAL A 297
LEU A 153
GLY A 155
THR A  25
 None
None
None
SO4  A 345 ( 3.5A)
SO4  A 344 ( 3.9A)
 1.03A 5igtA-3cerA:
undetectable		 5igtA-3cerA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN

(Pyrococcus
furiosus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		5 ILE A 102
VAL A 133
GLU A 164
ALA A 143
VAL A 117
 None
 1.06A 5igtA-3dm5A:
undetectable		 5igtA-3dm5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezq PROTEIN FADD

(Homo sapiens) 		PF00531
(Death) 		5 VAL B 180
ALA B 174
VAL B 103
LEU B 165
GLY B 163
 None
 0.98A 5igtA-3ezqB:
undetectable		 5igtA-3ezqB:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF02738
(Ald_Xan_dh_C2) 		5 ILE B  30
VAL B  38
ALA B  25
ALA B  26
VAL B  97
 None
 1.00A 5igtA-3hrdB:
undetectable		 5igtA-3hrdB:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6d PROTOPORPHYRINOGEN
OXIDASE

(Bacillus
subtilis) 		PF01593
(Amino_oxidase) 		6 PRO A 401
VAL A 314
ALA A 344
VAL A 387
GLY A 331
THR A 330
 None
 0.95A 5igtA-3i6dA:
undetectable		 5igtA-3i6dA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 1

(Thermus
thermophilus) 		PF01512
(Complex1_51K)
PF10531
(SLBB)
PF10589
(NADH_4Fe-4S) 		6 ILE 1 115
VAL 1 173
HIS 1 172
VAL 1 134
LEU 1 188
THR 1 216
 None
 1.25A 5igtA-3i9v1:
undetectable		 5igtA-3i9v1:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1e CHAPERONIN BETA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		5 ILE A 357
VAL A 317
ALA A 308
LEU A 253
GLY A 303
 None
 1.06A 5igtA-3j1eA:
undetectable		 5igtA-3j1eA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2z BIRA BIFUNCTIONAL
PROTEIN

(Mycobacterium
tuberculosis) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		5 ILE A  59
VAL A 155
ALA A 104
ALA A 105
VAL A 109
 None
 0.87A 5igtA-3l2zA:
undetectable		 5igtA-3l2zA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES

(Arabidopsis
thaliana) 		PF01048
(PNP_UDP_1) 		5 ILE A 215
PRO A 108
ALA A  34
VAL A  77
GLY A 115
 None
None
SAH  A 268 ( 4.4A)
None
None
 1.04A 5igtA-3lgsA:
undetectable		 5igtA-3lgsA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum) 		PF01593
(Amino_oxidase) 		5 PRO A 397
VAL A 312
ALA A 341
VAL A 383
GLY A 328
 None
 1.02A 5igtA-3lovA:
undetectable		 5igtA-3lovA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE

(Rhodobacter
capsulatus) 		PF00590
(TP_methylase) 		5 ILE A  51
VAL A  76
LEU A  84
GLY A 109
THR A  17
 None
 1.01A 5igtA-3ndcA:
undetectable		 5igtA-3ndcA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 ILE A 641
PRO A 638
VAL A 613
ALA A 591
GLY A 587
 None
 0.95A 5igtA-3ogrA:
1.0		 5igtA-3ogrA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oq9 PROTEIN FADD

(Homo sapiens) 		PF00531
(Death) 		5 VAL H 180
ALA H 174
VAL H 103
LEU H 165
GLY H 163
 None
 1.01A 5igtA-3oq9H:
undetectable		 5igtA-3oq9H:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhg PUTATIVE
PHOPHOTRIESTERASE

(Proteus
mirabilis) 		PF02126
(PTE) 		5 ILE A  74
ALA A 161
ALA A 121
VAL A 119
GLY A 153
 None
 1.03A 5igtA-3rhgA:
undetectable		 5igtA-3rhgA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5q PUTATIVE
GLYCOSYLHYDROLASE

(Parabacteroides
distasonis) 		PF06439
(DUF1080) 		5 HIS A 129
ALA A 168
VAL A 166
GLY A 153
THR A 198
 None
None
EDO  A 303 ( 4.4A)
EDO  A 308 ( 4.3A)
EDO  A 308 (-3.0A)
 1.02A 5igtA-3s5qA:
undetectable		 5igtA-3s5qA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV

(Bacillus
anthracis) 		PF00227
(Proteasome) 		6 VAL A  49
GLU A  17
ALA A  11
VAL A 104
LEU A 127
GLY A 125
 None
 1.41A 5igtA-3ty6A:
undetectable		 5igtA-3ty6A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti) 		PF00294
(PfkB) 		5 ILE A 211
VAL A   6
ALA A  65
VAL A  68
GLY A  59
 None
None
None
None
ADN  A 353 (-3.2A)
 1.06A 5igtA-3uboA:
undetectable		 5igtA-3uboA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Rhodobacter
sphaeroides) 		PF13561
(adh_short_C2) 		5 ILE A  18
VAL A  23
ALA A   9
LEU A  73
GLY A 124
 None
 1.02A 5igtA-3uxyA:
undetectable		 5igtA-3uxyA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3viu PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 2

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 ILE A 567
VAL A 621
ALA A 631
LEU A 695
GLY A 640
 None
 1.04A 5igtA-3viuA:
undetectable		 5igtA-3viuA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3s 6-PHOSPHOFRUCTOKINAS
E

(Bacillus
subtilis) 		PF00365
(PFK) 		6 HIS A  62
ALA A 264
ALA A  18
VAL A  20
GLY A 138
THR A 141
 None
 1.24A 5igtA-4a3sA:
undetectable		 5igtA-4a3sA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axv MPAA

(Vibrio
campbellii) 		PF04952
(AstE_AspA) 		6 ILE A 182
ALA A  45
VAL A 153
LEU A  58
GLY A  57
THR A 218
 None
 1.39A 5igtA-4axvA:
undetectable		 5igtA-4axvA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE

(Flavobacterium
sp. 141-8) 		PF13561
(adh_short_C2) 		5 ILE A  27
VAL A  32
GLU A 241
ALA A  18
LEU A  88
 None
 1.04A 5igtA-4cr6A:
undetectable		 5igtA-4cr6A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Thermobispora
bispora) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A  88
VAL A  84
ALA A  62
ALA A  61
VAL A 108
 None
 1.02A 5igtA-4dhgA:
undetectable		 5igtA-4dhgA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE

(Anaerococcus
prevotii) 		PF01071
(GARS_A) 		6 PRO A 283
GLU A 305
ALA A  72
ALA A  73
LEU A  84
GLY A  95
 None
 1.09A 5igtA-4dimA:
undetectable		 5igtA-4dimA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnv AT5G63860/MGI19_6

(Arabidopsis
thaliana) 		PF00415
(RCC1) 		6 PRO A 111
VAL A  72
ALA A  29
VAL A  36
LEU A 377
GLY A 361
 None
 1.39A 5igtA-4dnvA:
undetectable		 5igtA-4dnvA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnv AT5G63860/MGI19_6

(Arabidopsis
thaliana) 		PF00415
(RCC1) 		6 PRO A 215
VAL A 177
ALA A 134
VAL A 141
LEU A 117
GLY A 101
 None
 1.31A 5igtA-4dnvA:
undetectable		 5igtA-4dnvA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3a SUGAR KINASE PROTEIN

(Rhizobium etli) 		PF00294
(PfkB) 		5 ILE A 209
VAL A   4
ALA A  63
VAL A  66
GLY A  57
 None
None
None
None
ADN  A 500 (-3.7A)
 1.04A 5igtA-4e3aA:
undetectable		 5igtA-4e3aA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gh4 CAPSID PROTEIN VP1
CAPSID PROTEIN VP2

(Foot-and-mouth
disease virus;
Foot-and-mouth
disease virus) 		PF00073
(Rhv)
PF00073
(Rhv) 		5 ILE B 197
VAL B 109
VAL B 123
GLY A   5
THR A   4
 None
 1.04A 5igtA-4gh4B:
undetectable		 5igtA-4gh4B:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxy PLM1

(Streptomyces
sp. HK803) 		PF08659
(KR) 		5 PRO A  54
GLU A  30
ALA A  69
ALA A  70
VAL A  74
 None
 0.91A 5igtA-4hxyA:
undetectable		 5igtA-4hxyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxy PLM1

(Streptomyces
sp. HK803) 		PF08659
(KR) 		5 PRO A  54
VAL A  82
ALA A  69
ALA A  70
VAL A  74
 None
 0.92A 5igtA-4hxyA:
undetectable		 5igtA-4hxyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxy PLM1

(Streptomyces
sp. HK803) 		PF08659
(KR) 		5 VAL A  57
GLU A  30
ALA A  69
ALA A  70
VAL A  74
 None
 0.95A 5igtA-4hxyA:
undetectable		 5igtA-4hxyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6j F-BOX/LRR-REPEAT
PROTEIN 3

(Homo sapiens) 		PF12937
(F-box-like) 		5 ILE B 392
VAL B 380
GLU B 349
ALA B 355
GLY B 328
 None
 0.93A 5igtA-4i6jB:
undetectable		 5igtA-4i6jB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqk NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Salmonella
enterica) 		PF02277
(DBI_PRT) 		5 ILE A 137
GLU A 149
ALA A 274
ALA A 273
GLY A 248
 None
 0.99A 5igtA-4kqkA:
undetectable		 5igtA-4kqkA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lx4 ENDOGLUCANASE(ENDO-1
,4-BETA-GLUCANASE)PR
OTEIN

(Pseudomonas
stutzeri) 		PF00150
(Cellulase) 		5 ILE A 202
ALA A 155
ALA A 156
VAL A 160
GLY A 102
 None
 0.81A 5igtA-4lx4A:
undetectable		 5igtA-4lx4A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqz ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI

(Pseudomonas
aeruginosa) 		PF13561
(adh_short_C2) 		5 VAL A  67
ALA A 123
VAL A  94
LEU A 169
GLY A 172
 None
 1.02A 5igtA-4nqzA:
undetectable		 5igtA-4nqzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pka PATATIN-17

(Solanum
cardiophyllum) 		PF01734
(Patatin) 		5 ILE X 102
ALA X 189
ALA X 188
GLY X 127
TYR X 129
 None
None
MIS  X  77 ( 3.4A)
None
None
 0.85A 5igtA-4pkaX:
undetectable		 5igtA-4pkaX:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r27 GLYCOSIDE HYDROLASE

(Microbacterium
sp. Gsoil167) 		PF00232
(Glyco_hydro_1) 		5 ILE A 389
GLU A 141
ALA A 202
ALA A 201
GLY A 193
 None
 1.02A 5igtA-4r27A:
undetectable		 5igtA-4r27A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		5 ILE A 569
HIS A 597
ALA A 414
ALA A 415
VAL A 419
 None
None
BCR  A6007 ( 3.8A)
None
None
 1.04A 5igtA-4rkuA:
undetectable		 5igtA-4rkuA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpa PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Staphylococcus
aureus) 		PF01368
(DHH)
PF02833
(DHHA2) 		5 ILE A 257
VAL A 219
VAL A 227
LEU A 289
GLY A 291
 None
 1.03A 5igtA-4rpaA:
1.7		 5igtA-4rpaA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uds MBDR REGULATOR

(Azoarcus sp.
CIB) 		PF00440
(TetR_N) 		6 ILE A 135
VAL A 111
HIS A 110
GLY A  32
THR A  36
TYR A  33
 None
 1.26A 5igtA-4udsA:
undetectable		 5igtA-4udsA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y96 TRIOSEPHOSPHATE
ISOMERASE

(Gemmata
obscuriglobus) 		PF00121
(TIM) 		5 ILE A 250
ALA A 190
ALA A 187
VAL A 232
GLY A 132
 None
 0.96A 5igtA-4y96A:
undetectable		 5igtA-4y96A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R

(Homo sapiens;
Homo sapiens) 		PF12859
(ANAPC1)
PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		5 PRO R 152
ALA A1270
VAL A1272
LEU A1319
GLY A1315
 None
 1.03A 5igtA-5a31R:
2.7		 5igtA-5a31R:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5coa IRIDOID SYNTHASE

(Catharanthus
roseus) 		no annotation 6 ILE A 145
GLU A 256
ALA A 267
VAL A 271
LEU A 362
GLY A 363
 None
 1.27A 5igtA-5coaA:
undetectable		 5igtA-5coaA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eft P9-1

(Southern rice
black-streaked
dwarf virus) 		PF06043
(Reo_P9) 		5 ILE B 249
GLU B 221
LEU B  55
GLY B  51
TYR B  12
 None
 0.92A 5igtA-5eftB:
0.7		 5igtA-5eftB:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep8 PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE

(Bacillus
subtilis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 PRO A 242
VAL A 411
ALA A 340
VAL A 395
GLY A 344
 PRO  A 242 ( 1.1A)
VAL  A 411 ( 0.6A)
ALA  A 340 ( 0.0A)
VAL  A 395 ( 0.5A)
GLY  A 344 ( 0.0A)
 1.03A 5igtA-5ep8A:
undetectable		 5igtA-5ep8A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby SEPARASE

(Chaetomium
thermophilum) 		PF03568
(Peptidase_C50) 		5 VAL A2189
ALA A2205
ALA A2206
VAL A2139
THR A2146
 None
 1.03A 5igtA-5fbyA:
undetectable		 5igtA-5fbyA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbz ENZYME SUBTILASE
SUBHAL FROM BACILLUS
HALMAPALUS

(Bacillus
halmapalus) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 ILE A  96
HIS A  68
ALA A  73
LEU A  77
GLY A 262
 None
 1.00A 5igtA-5fbzA:
undetectable		 5igtA-5fbzA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5feu NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE

(Narcissus
pseudonarcissus) 		PF13561
(adh_short_C2) 		5 ILE A  37
VAL A  42
ALA A  28
LEU A 104
GLY A 155
 NAP  A 301 (-3.8A)
None
None
None
None
 0.91A 5igtA-5feuA:
undetectable		 5igtA-5feuA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5feu NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE

(Narcissus
pseudonarcissus) 		PF13561
(adh_short_C2) 		5 ILE A 203
ALA A  28
VAL A  30
LEU A 104
THR A 154
 None
 1.00A 5igtA-5feuA:
undetectable		 5igtA-5feuA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5feu NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE

(Narcissus
pseudonarcissus) 		PF13561
(adh_short_C2) 		6 VAL A  42
ALA A  28
VAL A  30
LEU A 104
GLY A 155
THR A 154
 None
 1.36A 5igtA-5feuA:
undetectable		 5igtA-5feuA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ff9 NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE

(Narcissus
pseudonarcissus) 		PF13561
(adh_short_C2) 		5 ILE A  37
VAL A  42
ALA A  28
LEU A 104
GLY A 155
 NAP  A 301 (-4.2A)
None
None
None
None
 0.90A 5igtA-5ff9A:
undetectable		 5igtA-5ff9A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fic SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		5 ILE A 440
ALA A 477
LEU A 479
GLY A 454
THR A 274
 None
 0.95A 5igtA-5ficA:
undetectable		 5igtA-5ficA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flw EXO-BETA-1,3-GALACTA
NASE

(Bifidobacterium
bifidum) 		PF04616
(Glyco_hydro_43) 		5 ILE A 172
VAL A 113
GLU A  82
VAL A  96
GLY A  24
 None
 0.92A 5igtA-5flwA:
1.9		 5igtA-5flwA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		6 ILE C 667
PRO C 668
ALA C 436
ALA C 701
VAL C 591
GLY C 438
 None
 1.37A 5igtA-5g5gC:
undetectable		 5igtA-5g5gC:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkv ESTERASE A

(Caulobacter
vibrioides) 		PF00144
(Beta-lactamase) 		5 VAL A  43
ALA A 370
VAL A  15
GLY A 320
TYR A 319
 None
 1.00A 5igtA-5gkvA:
undetectable		 5igtA-5gkvA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqn SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		5 ILE A 440
ALA A 477
LEU A 479
GLY A 454
THR A 274
 None
 0.97A 5igtA-5hqnA:
undetectable		 5igtA-5hqnA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3s UNCHARACTERIZED
PROTEIN

(Nostoc
punctiforme) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 MET A 308
ASP A 270
TYR A 305
PHE A 286
 None
 1.42A 5igtA-2r3sA:
0.0		 5igtA-2r3sA:
22.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E

(Escherichia
coli) 		PF01636
(APH) 		5 MET A 103
ASP A 200
TYR A 202
MET A 237
PHE A 280
 ERY  A 402 (-2.2A)
ERY  A 402 (-2.4A)
ERY  A 402 (-2.7A)
ERY  A 402 ( 3.0A)
ERY  A 402 ( 3.6A)
 0.51A 5igtA-5igpA:
48.0		 5igtA-5igpA:
100.00