SIMILAR PATTERNS OF AMINO ACIDS FOR 5IGP_A_ERYA402_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E

(Escherichia
coli) 		PF01636
(APH) 		4 ASP A 200
TYR A 202
MET A 237
PHE A 280
 ERY  A 402 (-2.4A)
ERY  A 402 (-2.7A)
ERY  A 402 ( 3.0A)
ERY  A 402 ( 3.6A)
 0.00A 5igpA-5igpA:
49.3		 5igpA-5igpA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vnc GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2

(Saccharomyces
cerevisiae) 		no annotation 4 ASP A 208
TYR A 507
MET A 330
PHE A 558
 None
 1.39A 5igpA-5vncA:
0.1		 5igpA-5vncA:
undetectable