SIMILAR PATTERNS OF AMINO ACIDS FOR 5IGP_A_ERYA402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2z PYRROLIDONE CARBOXYL
PEPTIDASE

(Thermococcus
litoralis) 		PF01470
(Peptidase_C15) 		5 ILE A  60
PRO A  62
VAL A  37
GLU A  21
GLY A  69
 None
 1.21A 5igpA-1a2zA:
0.0		 5igpA-1a2zA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)

(Amycolatopsis
mediterranei) 		PF01041
(DegT_DnrJ_EryC1) 		5 ILE A  89
VAL A  83
ALA A 140
GLY A 137
TYR A 291
 None
 1.28A 5igpA-1b9hA:
0.0		 5igpA-1b9hA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN

(Escherichia
coli) 		PF02126
(PTE) 		5 GLU A 125
VAL A 177
LEU A 169
GLY A 165
THR A 159
 ZN  A 293 ( 2.5A)
None
None
None
None
 1.46A 5igpA-1bf6A:
1.0		 5igpA-1bf6A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9l CLATHRIN

(Rattus
norvegicus) 		PF01394
(Clathrin_propel)
PF09268
(Clathrin-link) 		5 ILE A  53
ALA A 307
VAL A 305
GLY A 314
THR A 312
 None
 1.45A 5igpA-1c9lA:
0.0		 5igpA-1c9lA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eye DIHYDROPTEROATE
SYNTHASE I

(Mycobacterium
tuberculosis) 		PF00809
(Pterin_bind) 		5 ILE A  45
VAL A 252
ALA A 249
GLY A 203
THR A 202
 None
 1.41A 5igpA-1eyeA:
undetectable		 5igpA-1eyeA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eye DIHYDROPTEROATE
SYNTHASE I

(Mycobacterium
tuberculosis) 		PF00809
(Pterin_bind) 		5 VAL A 252
ALA A 249
VAL A   6
GLY A 203
THR A 202
 None
 1.33A 5igpA-1eyeA:
undetectable		 5igpA-1eyeA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		5 VAL A 121
ALA A 108
LEU A  17
GLY A  53
THR A  49
 None
 1.19A 5igpA-1gkeA:
undetectable		 5igpA-1gkeA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqs ISOCITRATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00180
(Iso_dh) 		5 MET A 386
ILE A 390
ALA A  38
VAL A  41
THR A  30
 None
 1.34A 5igpA-1hqsA:
0.0		 5igpA-1hqsA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE

(Methylobacterium
extorquens) 		PF09176
(Mpt_N) 		5 VAL A 172
GLU A 176
ALA A 159
ALA A 160
VAL A 164
 None
 1.42A 5igpA-1luaA:
0.0		 5igpA-1luaA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 PRO A  61
VAL A 160
ALA A 194
VAL A 197
THR A 173
 None
 1.07A 5igpA-1ps9A:
undetectable		 5igpA-1ps9A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgc PROTEIN (VIRUS
CAPSID PROTEIN VP1)
PROTEIN (VIRUS
CAPSID PROTEIN VP2)

(Foot-and-mouth
disease virus;
Foot-and-mouth
disease virus) 		PF00073
(Rhv)
PF00073
(Rhv) 		5 ILE 2 197
VAL 2 109
VAL 2 123
GLY 1   5
THR 1   4
 None
 1.05A 5igpA-1qgc2:
undetectable		 5igpA-1qgc2:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh5 PROTEIN
(HYDROXYACYLGLUTATHI
ONE HYDROLASE)

(Homo sapiens) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		5 ILE A  89
ALA A  25
ALA A  26
VAL A  28
LEU A  47
 None
 1.29A 5igpA-1qh5A:
undetectable		 5igpA-1qh5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh5 PROTEIN
(HYDROXYACYLGLUTATHI
ONE HYDROLASE)

(Homo sapiens) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		5 ILE A 115
VAL A  28
ALA A  25
ALA A  26
GLY A  98
 None
 1.43A 5igpA-1qh5A:
undetectable		 5igpA-1qh5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qqf PROTEIN (COMPLEMENT
C3DG)

(Rattus
norvegicus) 		PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		5 ALA A1195
ALA A1192
VAL A1189
LEU A1196
GLY A1173
 None
 1.30A 5igpA-1qqfA:
undetectable		 5igpA-1qqfA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)

(Escherichia
coli) 		PF01464
(SLT)
PF14718
(SLT_L) 		5 ILE A 570
VAL A 576
ALA A 551
ALA A 550
GLY A 557
 None
 1.44A 5igpA-1qsaA:
undetectable		 5igpA-1qsaA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qy9 HYPOTHETICAL PROTEIN
YDDE

(Escherichia
coli) 		PF02567
(PhzC-PhzF) 		5 ILE A  60
VAL A  82
GLU A 108
ALA A 285
VAL A   8
 None
 0.93A 5igpA-1qy9A:
undetectable		 5igpA-1qy9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		5 ILE A 186
VAL A 125
LEU A 149
GLY A 151
THR A 152
 None
 1.29A 5igpA-1rf5A:
undetectable		 5igpA-1rf5A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si1 IRON BINDING PROTEIN
FBPA

(Mannheimia
haemolytica) 		PF13343
(SBP_bac_6) 		5 ILE A 194
ALA A 303
ALA A 304
VAL A 308
TYR A 154
 None
 0.55A 5igpA-1si1A:
undetectable		 5igpA-1si1A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		5 ILE A 270
GLU A  84
ALA A  68
ALA A  65
VAL A  62
 None
 1.32A 5igpA-1szsA:
undetectable		 5igpA-1szsA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txk GLUCANS BIOSYNTHESIS
PROTEIN G

(Escherichia
coli) 		PF04349
(MdoG) 		5 PRO A 290
GLU A 456
VAL A 429
GLY A 410
THR A 424
 None
 0.90A 5igpA-1txkA:
0.7		 5igpA-1txkA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl8 GLUCONATE
5-DEHYDROGENASE

(Thermotoga
maritima) 		PF13561
(adh_short_C2) 		5 ILE A 188
GLU A 236
ALA A  12
VAL A  14
LEU A  88
 None
 1.14A 5igpA-1vl8A:
undetectable		 5igpA-1vl8A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vma CELL DIVISION
PROTEIN FTSY

(Thermotoga
maritima) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		6 ILE A 207
PRO A  92
ALA A 127
ALA A 126
VAL A 124
LEU A 139
 None
 1.38A 5igpA-1vmaA:
undetectable		 5igpA-1vmaA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN

(Thermus
thermophilus) 		PF02615
(Ldh_2) 		5 GLU A  81
ALA A  92
ALA A  89
LEU A 263
GLY A 109
 None
 1.30A 5igpA-1x0aA:
undetectable		 5igpA-1x0aA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3z DIALKYLGLYCINE
DECARBOXYLASE

(Burkholderia
cepacia) 		PF00202
(Aminotran_3) 		5 ILE A 289
VAL A 284
ALA A 281
ALA A 282
THR A 302
 None
 1.36A 5igpA-1z3zA:
undetectable		 5igpA-1z3zA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9v CONSERVED
HYPOTHETICAL PROTEIN
MTH0776

(Methanothermobacter
thermautotrophicus) 		PF08979
(DUF1894) 		5 ILE A  72
PRO A  73
VAL A  84
ALA A  29
ALA A  30
 None
 1.15A 5igpA-1z9vA:
undetectable		 5igpA-1z9vA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 ALA A1194
ALA A1191
VAL A1188
LEU A1195
GLY A1172
 None
 1.31A 5igpA-2b39A:
undetectable		 5igpA-2b39A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 ILE A 120
ALA A 258
ALA A 255
VAL A 252
LEU A 259
 None
 1.45A 5igpA-2dsjA:
1.4		 5igpA-2dsjA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5v PYRANOSE 2-OXIDASE

(Peniophora sp.
SG) 		PF05199
(GMC_oxred_C) 		5 ILE A 295
ALA A 320
VAL A  52
GLY A 584
THR A 552
 None
FAD  A1625 (-3.6A)
FAD  A1625 (-4.8A)
None
None
 1.21A 5igpA-2f5vA:
undetectable		 5igpA-2f5vA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hy5 DSRH

(Allochromatium
vinosum) 		PF04077
(DsrH) 		5 GLU C 434
ALA C 440
ALA C 439
VAL C 446
LEU C 441
 None
 1.34A 5igpA-2hy5C:
undetectable		 5igpA-2hy5C:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jty TYPE-1 FIMBRIAL
PROTEIN, A CHAIN

(Escherichia
coli) 		PF00419
(Fimbrial) 		5 GLU A 180
ALA A 150
VAL A 175
LEU A  86
GLY A 100
 None
 1.46A 5igpA-2jtyA:
undetectable		 5igpA-2jtyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE

(Staphylococcus
aureus) 		PF13378
(MR_MLE_C) 		5 ILE A  34
VAL A 104
ALA A  85
ALA A  86
VAL A  90
 None
 0.97A 5igpA-2olaA:
undetectable		 5igpA-2olaA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlt (DL)-GLYCEROL-3-PHOS
PHATASE 1

(Saccharomyces
cerevisiae) 		PF13419
(HAD_2) 		5 ILE A 152
ALA A  35
ALA A  36
LEU A 181
GLY A 177
 None
 1.30A 5igpA-2qltA:
undetectable		 5igpA-2qltA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vaw CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 ILE A 164
GLU A 149
ALA A 113
ALA A 114
GLY A 108
 None
None
None
None
GDP  A1317 (-3.4A)
 1.21A 5igpA-2vawA:
undetectable		 5igpA-2vawA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xlr FLAVIN-CONTAINING
MONOOXYGENASE

(Methylophaga
aminisulfidivorans) 		PF00743
(FMO-like) 		5 PRO A 348
VAL A 308
ALA A 334
ALA A 337
VAL A 340
 None
 1.47A 5igpA-2xlrA:
undetectable		 5igpA-2xlrA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT C3B
ALPHA' CHAIN

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		5 ALA B1173
ALA B1170
VAL B1167
LEU B1174
GLY B1151
 None
 1.29A 5igpA-2xwbB:
undetectable		 5igpA-2xwbB:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwx GLCNAC-BINDING
PROTEIN A

(Vibrio cholerae) 		PF03067
(LPMO_10) 		5 PRO A  63
VAL A  27
ALA A  29
GLY A  48
THR A  49
 None
 1.47A 5igpA-2xwxA:
undetectable		 5igpA-2xwxA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		5 VAL A   9
ALA A  40
ALA A  41
VAL A  90
LEU A  93
 None
AMP  A1302 (-3.6A)
None
None
AMP  A1302 ( 3.6A)
 1.45A 5igpA-2yabA:
7.2		 5igpA-2yabA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybu ACIDIC MAMMALIAN
CHITINASE

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 ILE A 120
VAL A 180
ALA A 183
ALA A 182
GLY A  98
 None
None
CX9  A1398 ( 4.6A)
None
CX9  A1398 (-3.5A)
 1.39A 5igpA-2ybuA:
undetectable		 5igpA-2ybuA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybu ACIDIC MAMMALIAN
CHITINASE

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 MET A 162
ILE A 120
ALA A 183
ALA A 182
GLY A  98
 None
None
CX9  A1398 ( 4.6A)
None
CX9  A1398 (-3.5A)
 1.40A 5igpA-2ybuA:
undetectable		 5igpA-2ybuA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymv ACG NITROREDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 5 ILE A 290
PRO A 296
ALA A 168
ALA A 167
VAL A 276
 None
 1.33A 5igpA-2ymvA:
undetectable		 5igpA-2ymvA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E

(Thermus
thermophilus) 		PF00590
(TP_methylase) 		5 ALA A  67
ALA A  64
LEU A  79
GLY A  33
TYR A  34
 None
 1.17A 5igpA-2zvbA:
undetectable		 5igpA-2zvbA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abi PUTATIVE
UNCHARACTERIZED
PROTEIN PH1688

(Pyrococcus
horikoshii) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 VAL A 110
GLU A 100
ALA A  80
ALA A  81
GLY A  74
 None
 1.30A 5igpA-3abiA:
undetectable		 5igpA-3abiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azq AMINOPEPTIDASE

(Streptomyces
morookaense) 		PF00326
(Peptidase_S9) 		5 VAL A 144
ALA A  83
VAL A  95
GLY A  30
THR A 343
 None
 1.43A 5igpA-3azqA:
0.5		 5igpA-3azqA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8a HEXOKINASE-1

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ALA X 392
ALA X 393
VAL X 397
GLY X 307
THR X 344
 None
 1.19A 5igpA-3b8aX:
undetectable		 5igpA-3b8aX:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cer POSSIBLE
EXOPOLYPHOSPHATASE-L
IKE PROTEIN

(Bifidobacterium
longum) 		PF02541
(Ppx-GppA) 		5 PRO A 197
VAL A 297
LEU A 153
GLY A 155
THR A  25
 None
None
None
SO4  A 345 ( 3.5A)
SO4  A 344 ( 3.9A)
 1.03A 5igpA-3cerA:
undetectable		 5igpA-3cerA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		5 ILE A 251
ALA A 142
ALA A 141
VAL A 137
GLY A  53
 None
 1.33A 5igpA-3cghA:
undetectable		 5igpA-3cghA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq0 PUTATIVE
TRANSALDOLASE
YGR043C

(Saccharomyces
cerevisiae) 		PF00923
(TAL_FSA) 		5 ILE A 322
VAL A 329
ALA A  66
ALA A  67
THR A  95
 GOL  A 351 (-3.8A)
None
None
None
None
 1.25A 5igpA-3cq0A:
undetectable		 5igpA-3cq0A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7n D-RIBOSE
HIGH-AFFINITY
TRANSPORT SYSTEM

(Salmonella
enterica) 		PF05025
(RbsD_FucU) 		5 MET A  62
ILE A  15
VAL A  64
ALA A  67
LEU A  69
 None
 1.35A 5igpA-3e7nA:
undetectable		 5igpA-3e7nA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG

(Homo sapiens) 		PF09445
(Methyltransf_15) 		5 ILE A 718
VAL A 715
LEU A 845
THR A 839
TYR A 803
 None
 1.31A 5igpA-3egiA:
undetectable		 5igpA-3egiA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ILE A 455
GLU A 422
ALA A  57
ALA A  56
VAL A  52
 None
 1.43A 5igpA-3eyaA:
undetectable		 5igpA-3eyaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvq FE(3+) IONS IMPORT
ATP-BINDING PROTEIN
FBPC

(Neisseria
gonorrhoeae) 		PF00005
(ABC_tran) 		5 VAL A  86
ALA A 147
ALA A 148
VAL A  90
GLY A 142
 None
 1.42A 5igpA-3fvqA:
undetectable		 5igpA-3fvqA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glg DNA POLYMERASE III
SUBUNIT DELTA

(Escherichia
coli) 		PF06144
(DNA_pol3_delta)
PF14840
(DNA_pol3_delt_C) 		5 PRO A  89
VAL A 112
ALA A  19
ALA A  20
LEU A 104
 None
 1.23A 5igpA-3glgA:
undetectable		 5igpA-3glgA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6d PROTOPORPHYRINOGEN
OXIDASE

(Bacillus
subtilis) 		PF01593
(Amino_oxidase) 		5 PRO A 401
VAL A 314
ALA A 344
VAL A 387
GLY A 331
 None
 0.83A 5igpA-3i6dA:
undetectable		 5igpA-3i6dA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6d PROTOPORPHYRINOGEN
OXIDASE

(Bacillus
subtilis) 		PF01593
(Amino_oxidase) 		5 PRO A 401
VAL A 314
VAL A 387
GLY A 331
THR A 330
 None
 0.94A 5igpA-3i6dA:
undetectable		 5igpA-3i6dA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq1 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 ALA A 196
VAL A 140
LEU A 145
GLY A 149
TYR A 151
 None
 1.26A 5igpA-3jq1A:
undetectable		 5igpA-3jq1A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l86 ACETYLGLUTAMATE
KINASE

(Streptococcus
mutans) 		PF00696
(AA_kinase) 		5 ILE A 140
PRO A 141
VAL A   6
ALA A 163
VAL A 166
 None
 1.11A 5igpA-3l86A:
undetectable		 5igpA-3l86A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 ILE A 641
PRO A 638
VAL A 613
ALA A 591
GLY A 587
 None
 0.96A 5igpA-3ogrA:
undetectable		 5igpA-3ogrA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otm CARBONIC ANHYDRASE

(Methanosarcina
thermophila) 		PF00132
(Hexapep)
PF14602
(Hexapep_2) 		5 VAL A 127
GLU A 104
ALA A 125
VAL A 121
GLY A  63
 None
 1.29A 5igpA-3otmA:
undetectable		 5igpA-3otmA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A  15
VAL A  12
ALA A  73
GLY A 107
THR A 166
 None
 1.25A 5igpA-3oytA:
undetectable		 5igpA-3oytA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppx VON WILLEBRAND
FACTOR

(Homo sapiens) 		PF00092
(VWA) 		5 MET A1528
ILE A1535
VAL A1524
GLU A1549
VAL A1665
 None
 1.14A 5igpA-3ppxA:
undetectable		 5igpA-3ppxA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3y THREE PRIME REPAIR
EXONUCLEASE 1

(Mus musculus) 		no annotation 5 PRO B   7
VAL B 153
ALA B 158
VAL B 219
LEU B 162
 None
 1.27A 5igpA-3u3yB:
undetectable		 5igpA-3u3yB:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5g ANIONIC PEROXIDASE

(Raphanus
sativus) 		PF00141
(peroxidase) 		5 ILE A  55
VAL A  82
ALA A 109
ALA A 106
VAL A 102
 None
 1.26A 5igpA-4a5gA:
undetectable		 5igpA-4a5gA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3c SFN68 FAB

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 PRO L   8
VAL L 105
ALA L  14
ALA L  13
VAL L  19
 None
 1.12A 5igpA-4d3cL:
undetectable		 5igpA-4d3cL:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE

(Anaerococcus
prevotii) 		PF01071
(GARS_A) 		5 PRO A 283
GLU A 305
ALA A  72
ALA A  73
GLY A  95
 None
 0.94A 5igpA-4dimA:
undetectable		 5igpA-4dimA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ht1 CHIMERIC ANTIBODY
FAB

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 PRO L   8
VAL L 108
ALA L  14
ALA L  13
VAL L  19
 None
 1.28A 5igpA-4ht1L:
undetectable		 5igpA-4ht1L:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxy PLM1

(Streptomyces
sp. HK803) 		PF08659
(KR) 		5 MET A 392
ILE A 396
ALA A 274
ALA A 273
GLY A 300
 None
None
NDP  A 501 (-3.8A)
NDP  A 501 (-3.9A)
None
 1.44A 5igpA-4hxyA:
undetectable		 5igpA-4hxyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0w PROTEASE CSPB

(Clostridium
perfringens) 		PF00082
(Peptidase_S8) 		5 ILE B 215
ALA B 496
ALA B 497
VAL B 283
GLY B 492
 None
 1.31A 5igpA-4i0wB:
undetectable		 5igpA-4i0wB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igm 2-AMINO-3-CARBOXYMUC
ONATE-6-SEMIALDEHYDE
DECARBOXYLASE

(Homo sapiens) 		PF04909
(Amidohydro_2) 		5 MET A  63
ILE A  60
VAL A  68
ALA A 324
LEU A 325
 None
 1.36A 5igpA-4igmA:
undetectable		 5igpA-4igmA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqk NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Salmonella
enterica) 		PF02277
(DBI_PRT) 		5 ILE A 137
GLU A 149
ALA A 274
ALA A 273
GLY A 248
 None
 0.97A 5igpA-4kqkA:
undetectable		 5igpA-4kqkA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4

(Homo sapiens) 		PF01663
(Phosphodiest) 		5 MET A 374
ILE A 370
ALA A 132
ALA A 181
TYR A 184
 None
 1.23A 5igpA-4lr2A:
undetectable		 5igpA-4lr2A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o0e ISOASPARTYL
PEPTIDASE/L-ASPARAGI
NASE

(Homo sapiens) 		PF01112
(Asparaginase_2) 		5 ALA A  47
ALA A  44
VAL A 180
LEU A  38
GLY A  41
 None
 1.39A 5igpA-4o0eA:
undetectable		 5igpA-4o0eA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o3s DNA POLYMERASE ETA

(Homo sapiens) 		PF00817
(IMS)
PF11799
(IMS_C) 		5 MET A 200
ILE A 196
ALA A 112
ALA A 117
VAL A  12
 None
 0.91A 5igpA-4o3sA:
undetectable		 5igpA-4o3sA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onq DNA
METHYLTRANSFERASE

(Nicotiana
tabacum) 		PF00145
(DNA_methylase) 		5 PRO A 365
VAL A 393
VAL A 408
LEU A 385
GLY A 381
 None
 1.38A 5igpA-4onqA:
undetectable		 5igpA-4onqA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pka PATATIN-17

(Solanum
cardiophyllum) 		PF01734
(Patatin) 		5 ILE X 102
ALA X 189
ALA X 188
GLY X 127
TYR X 129
 None
None
MIS  X  77 ( 3.4A)
None
None
 0.83A 5igpA-4pkaX:
undetectable		 5igpA-4pkaX:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxn UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00171
(Aldedh) 		5 ILE A 197
GLU A 267
ALA A 179
ALA A 176
GLY A 160
 None
NAD  A 601 (-4.3A)
None
None
None
 1.29A 5igpA-4pxnA:
undetectable		 5igpA-4pxnA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN

(Nitratireductor
pacificus) 		PF12838
(Fer4_7)
PF13486
(Dehalogenase) 		5 ILE A 137
ALA A 438
VAL A 435
GLY A 444
THR A 340
 None
 1.44A 5igpA-4rasA:
undetectable		 5igpA-4rasA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		5 ILE A 610
ALA A 524
ALA A 523
LEU A 483
GLY A 594
 None
 1.27A 5igpA-4y93A:
2.1		 5igpA-4y93A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1
SOMATIC
EMBRYOGENESIS
RECEPTOR KINASE 1

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 ILE A 611
PRO A 612
VAL A 602
ALA A 575
TYR C  97
 None
 1.34A 5igpA-4z64A:
undetectable		 5igpA-4z64A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxl O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		5 ILE A 168
VAL A 136
ALA A 125
ALA A 134
GLY A 151
 None
 1.29A 5igpA-4zxlA:
undetectable		 5igpA-4zxlA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 MET A 208
ILE A 193
ALA A 239
ALA A 240
GLY A 235
 None
 1.32A 5igpA-5dmyA:
undetectable		 5igpA-5dmyA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8e IGA FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL B 212
GLU B 168
ALA B 150
VAL B 153
LEU B 136
 None
 1.35A 5igpA-5e8eB:
undetectable		 5igpA-5e8eB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f38 ACETYL-COA
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ILE B 102
VAL B 258
ALA B 255
ALA B 256
GLY B 355
 None
None
None
None
CSX  B  88 ( 4.3A)
 1.47A 5igpA-5f38B:
undetectable		 5igpA-5f38B:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flw EXO-BETA-1,3-GALACTA
NASE

(Bifidobacterium
bifidum) 		PF04616
(Glyco_hydro_43) 		5 ILE A 172
VAL A 113
GLU A  82
VAL A  96
GLY A  24
 None
 0.91A 5igpA-5flwA:
1.8		 5igpA-5flwA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6j PIERISIN-1

(Pieris rapae) 		no annotation 5 PRO A  93
ALA A  14
ALA A  15
VAL A  17
GLY A 147
 None
 1.40A 5igpA-5h6jA:
undetectable		 5igpA-5h6jA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6n PIERISIN-1

(Pieris rapae) 		no annotation 5 PRO A  93
ALA A  14
ALA A  15
VAL A  17
GLY A 147
 None
 1.36A 5igpA-5h6nA:
undetectable		 5igpA-5h6nA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ica PUTATIVE
UNCHARACTERIZED
PROTEIN
PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		PF04003
(Utp12)
PF08625
(Utp13) 		5 ILE B 806
GLU A 916
ALA A 922
ALA A 923
VAL A 927
 None
 1.07A 5igpA-5icaB:
undetectable		 5igpA-5icaB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idu ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN

(Paraburkholderia
phymatum) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ILE A 162
ALA A 133
ALA A 134
GLY A 108
THR A 248
 None
 1.36A 5igpA-5iduA:
undetectable		 5igpA-5iduA:
24.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E

(Escherichia
coli) 		PF01636
(APH) 		12 MET A 103
ILE A 105
PRO A 112
VAL A 203
GLU A 222
ALA A 233
ALA A 234
VAL A 238
LEU A 270
GLY A 273
THR A 276
TYR A 277
 ERY  A 402 (-2.2A)
ERY  A 402 ( 4.4A)
ERY  A 402 ( 4.1A)
None
ERY  A 402 ( 3.9A)
ERY  A 402 ( 3.9A)
ERY  A 402 ( 3.2A)
ERY  A 402 ( 4.7A)
None
ERY  A 402 ( 3.6A)
ERY  A 402 ( 3.8A)
ERY  A 402 ( 4.5A)
 0.28A 5igpA-5igpA:
49.3		 5igpA-5igpA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy1 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Paraburkholderia
xenovorans) 		PF13561
(adh_short_C2) 		5 ILE A 184
GLU A 233
ALA A   9
VAL A  11
LEU A  84
 None
 0.85A 5igpA-5jy1A:
undetectable		 5igpA-5jy1A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kij ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Homo sapiens) 		PF01532
(Glyco_hydro_47) 		5 ILE A 372
GLU A 330
ALA A 462
VAL A 439
THR A 688
 None
MAN  A 707 ( 4.2A)
None
None
MAN  A 707 ( 3.2A)
 1.35A 5igpA-5kijA:
undetectable		 5igpA-5kijA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm2 CAPSID PROTEIN VP4C

(Nora virus) 		no annotation 5 PRO A  46
ALA A 207
VAL A 163
GLY A 183
THR A 198
 None
 1.36A 5igpA-5mm2A:
undetectable		 5igpA-5mm2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngw OPGH99A

(Ochrovirga
pacifica) 		no annotation 5 ILE A 213
ALA A 315
ALA A 316
VAL A 320
GLY A 262
 None
 1.19A 5igpA-5ngwA:
undetectable		 5igpA-5ngwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no4 30S RIBOSOMAL
PROTEIN S7

(Escherichia
coli) 		PF00177
(Ribosomal_S7) 		5 ILE G  29
GLU G  58
ALA G 128
ALA G  65
VAL G  69
 None
 1.13A 5igpA-5no4G:
undetectable		 5igpA-5no4G:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 5 GLU A 178
ALA A 597
ALA A 598
LEU A 186
GLY A 184
 None
 1.02A 5igpA-5nqdA:
undetectable		 5igpA-5nqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofb MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
2

(Homo sapiens) 		no annotation 5 ILE B 111
ALA B  43
ALA B  40
GLY B 196
THR B 119
 None
ATP  B 702 (-3.4A)
ATP  B 702 ( 4.6A)
MG  B 704 ( 4.5A)
None
 1.47A 5igpA-5ofbB:
undetectable		 5igpA-5ofbB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olc GALACTONATE
DEHYDRATASE

(Zobellia
galactanivorans) 		no annotation 5 ILE A 265
ALA A 306
ALA A 307
VAL A 311
GLY A 275
 None
 0.75A 5igpA-5olcA:
undetectable		 5igpA-5olcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucg STAGE II SPORULATION
PROTEIN E

(Bacillus
subtilis) 		PF07228
(SpoIIE) 		5 VAL A 802
ALA A 625
ALA A 624
LEU A 682
THR A 700
 None
 1.18A 5igpA-5ucgA:
undetectable		 5igpA-5ucgA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cvz E3 UBIQUITIN-PROTEIN
LIGASE RFWD3

(Homo sapiens) 		no annotation 5 VAL A 580
GLU A 619
ALA A 609
LEU A 591
TYR A 554
 None
 1.45A 5igpA-6cvzA:
1.9		 5igpA-6cvzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es9 ACYL-COA
DEHYDROGENASE

(Paracoccus
denitrificans) 		no annotation 5 ILE A 111
PRO A 112
GLU A 487
ALA A 419
VAL A 498
 None
 1.17A 5igpA-6es9A:
undetectable		 5igpA-6es9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 5 ILE A1604
ALA A1542
ALA A1566
LEU A1541
TYR A1586
 None
 1.09A 5igpA-6fb3A:
undetectable		 5igpA-6fb3A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E

(Escherichia
coli) 		PF01636
(APH) 		4 ASP A 200
TYR A 202
MET A 237
PHE A 280
 ERY  A 402 (-2.4A)
ERY  A 402 (-2.7A)
ERY  A 402 ( 3.0A)
ERY  A 402 ( 3.6A)
 0.00A 5igpA-5igpA:
49.3		 5igpA-5igpA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vnc GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2

(Saccharomyces
cerevisiae) 		no annotation 4 ASP A 208
TYR A 507
MET A 330
PHE A 558
 None
 1.39A 5igpA-5vncA:
0.1		 5igpA-5vncA:
undetectable