SIMILAR PATTERNS OF AMINO ACIDS FOR 5IGJ_A_CTYA402_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2v METHYLAMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 PRO A 582
HIS A 618
LEU A 409
PHE A 293
 None
 1.41A 5igjA-1a2vA:
0.1		 5igjA-1a2vA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)

(Rattus
norvegicus) 		PF00171
(Aldedh) 		4 PRO A 138
LEU A  70
TYR A 412
PHE A 401
 None
 1.43A 5igjA-1ad3A:
0.0		 5igjA-1ad3A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT
[NIFE] HYDROGENASE
SMALL SUBUNIT

(Desulfovibrio
desulfuricans) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 PRO A 151
HIS B 112
LEU A  35
TYR A  28
 FSX  A 269 (-3.8A)
None
None
None
 1.37A 5igjA-1e3dA:
undetectable		 5igjA-1e3dA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gc7 RADIXIN

(Mus musculus) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 PRO A 154
LEU A 234
TYR A 201
PHE A  85
 PRO  A 154 ( 1.1A)
LEU  A 234 ( 0.6A)
TYR  A 201 ( 1.3A)
PHE  A  85 ( 1.3A)
 1.26A 5igjA-1gc7A:
undetectable		 5igjA-1gc7A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjv CHITINASE-3 LIKE
PROTEIN 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 PRO A 142
LEU A 254
TYR A 243
PHE A 234
 None
 1.24A 5igjA-1hjvA:
undetectable		 5igjA-1hjvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k26 NUDIX HOMOLOG

(Pyrobaculum
aerophilum) 		PF00293
(NUDIX) 		4 PRO A  38
HIS A  31
TYR A  27
PHE A 122
 None
IR3  A 206 (-4.0A)
None
GOL  A 209 ( 4.8A)
 1.46A 5igjA-1k26A:
0.0		 5igjA-1k26A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfw PEPV

(Lactobacillus
delbrueckii) 		PF01546
(Peptidase_M20) 		4 PRO A 220
HIS A 308
LEU A 207
TYR A 239
 None
 1.20A 5igjA-1lfwA:
0.8		 5igjA-1lfwA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqa TAS PROTEIN

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		4 HIS A   4
LEU A 307
TYR A 208
PHE A 215
 None
 1.27A 5igjA-1lqaA:
0.0		 5igjA-1lqaA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwh 4-ALPHA-GLUCANOTRANS
FERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09178
(DUF1945) 		4 PRO A 308
HIS A 375
LEU A 404
PHE A 289
 None
 1.48A 5igjA-1lwhA:
undetectable		 5igjA-1lwhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1l SUPPRESSOR OF FUSED

(Homo sapiens) 		PF05076
(SUFU) 		4 PRO A 134
HIS A  89
LEU A 144
PHE A  93
 None
 1.35A 5igjA-1m1lA:
undetectable		 5igjA-1m1lA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mco IGG1 MCG INTACT
ANTIBODY (HEAVY
CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PRO H 229
HIS H 420
LEU H 391
TYR H 358
 GAL  H 435 (-4.8A)
None
None
None
 1.06A 5igjA-1mcoH:
undetectable		 5igjA-1mcoH:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlu SEDOLISIN

(Pseudomonas sp.) 		no annotation 4 PRO A 260
LEU A 361
TYR A  17
PHE A  13
 None
 1.43A 5igjA-1nluA:
undetectable		 5igjA-1nluA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		4 PRO A 520
HIS A 515
LEU A  28
TYR A  36
 None
 1.47A 5igjA-1obhA:
undetectable		 5igjA-1obhA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sma MALTOGENIC AMYLASE

(Thermus sp.
IM6501) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 PRO A 453
LEU A 486
TYR A 457
PHE A 145
 None
 1.48A 5igjA-1smaA:
3.2		 5igjA-1smaA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus) 		PF00135
(COesterase) 		4 PRO A  90
HIS A 451
TYR A 146
PHE A 485
 None
 1.46A 5igjA-1thgA:
undetectable		 5igjA-1thgA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 PRO B 339
HIS B 170
LEU B 181
PHE A 408
 None
 1.45A 5igjA-1tqyB:
undetectable		 5igjA-1tqyB:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf8 SECRETORY PROTEIN

(Mus musculus) 		PF00704
(Glyco_hydro_18) 		4 PRO A 269
HIS A 248
LEU A 289
TYR A 283
 None
 1.45A 5igjA-1vf8A:
undetectable		 5igjA-1vf8A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3w PEPTIDE:N-GLYCANASE

(Saccharomyces
cerevisiae) 		PF03835
(Rad4) 		4 PRO A 244
LEU A 202
TYR A 211
PHE A 261
 None
 1.46A 5igjA-1x3wA:
undetectable		 5igjA-1x3wA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT

(Homo sapiens) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		4 PRO A  54
HIS A  71
LEU A 128
PHE A 241
 None
ZN  A 482 (-3.5A)
None
None
 1.49A 5igjA-2i7tA:
undetectable		 5igjA-2i7tA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1

(Arabidopsis
thaliana) 		PF00724
(Oxidored_FMN) 		4 PRO A  15
LEU A  60
TYR A 325
PHE A 306
 None
 1.37A 5igjA-2q3rA:
undetectable		 5igjA-2q3rA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v79 DNA REPLICATION
PROTEIN DNAD

(Bacillus
subtilis) 		no annotation 4 PRO A 101
LEU A  57
TYR A  50
PHE A  94
 None
 1.31A 5igjA-2v79A:
undetectable		 5igjA-2v79A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vge RELA-ASSOCIATED
INHIBITOR

(Homo sapiens) 		PF00023
(Ank)
PF14604
(SH3_9) 		4 PRO A 696
HIS A 715
LEU A 640
TYR A 673
 None
 1.46A 5igjA-2vgeA:
undetectable		 5igjA-2vgeA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsm HEMAGGLUTININ-NEURAM
INIDASE

(Nipah
henipavirus) 		PF00423
(HN) 		4 PRO A 535
LEU A 222
TYR A 454
PHE A 466
 None
None
IPA  A1604 (-4.5A)
None
 1.39A 5igjA-2vsmA:
1.8		 5igjA-2vsmA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wuy POLYHEDRIN

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00738
(Polyhedrin) 		4 PRO A 149
HIS A 139
LEU A  71
TYR A  95
 None
 1.48A 5igjA-2wuyA:
undetectable		 5igjA-2wuyA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzr UNSATURATED
GLUCURONYL HYDROLASE

(Streptococcus
agalactiae) 		PF07470
(Glyco_hydro_88) 		4 PRO A 257
LEU A 340
TYR A 381
PHE A  73
 None
 1.22A 5igjA-2zzrA:
undetectable		 5igjA-2zzrA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzr UNSATURATED
GLUCURONYL HYDROLASE

(Streptococcus
agalactiae) 		PF07470
(Glyco_hydro_88) 		4 PRO A 257
LEU A 343
TYR A 381
PHE A  73
 None
 1.26A 5igjA-2zzrA:
undetectable		 5igjA-2zzrA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Rattus
norvegicus) 		PF06325
(PrmA) 		4 PRO A 374
LEU A 467
TYR A 449
PHE A 265
 None
BEN  A1001 (-4.5A)
BEN  A6001 ( 4.1A)
BEN  A4001 ( 4.0A)
 1.49A 5igjA-3b3jA:
1.0		 5igjA-3b3jA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb6 UNCHARACTERIZED
PROTEIN YEAR

(Escherichia
coli) 		PF09313
(DUF1971) 		4 PRO A  63
HIS A  30
LEU A   2
PHE A  94
 None
ZN  A 128 (-4.1A)
None
None
 1.41A 5igjA-3bb6A:
undetectable		 5igjA-3bb6A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfh MANDELATE RACEMASE

(Vibrionales
bacterium
SWAT-3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PRO A 237
HIS A 209
LEU A 188
PHE A 231
 None
 1.42A 5igjA-3dfhA:
undetectable		 5igjA-3dfhA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 HIS A 352
LEU A 568
TYR A 579
PHE A 578
 None
TDM  A 700 (-3.8A)
None
None
 1.43A 5igjA-3e9yA:
undetectable		 5igjA-3e9yA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 PRO A 299
HIS A 497
LEU A 409
PHE A 330
 None
HBX  A 530 ( 3.9A)
None
HBX  A 530 (-4.0A)
 1.46A 5igjA-3gdnA:
undetectable		 5igjA-3gdnA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjw 50S RIBOSOMAL
PROTEIN L7AE
PSEUDOURIDINE
SYNTHASE CBF5

(Pyrococcus
furiosus) 		PF01248
(Ribosomal_L7Ae)
PF01472
(PUA)
PF01509
(TruB_N)
PF08068
(DKCLD)
PF16198
(TruB_C_2) 		4 PRO C  60
LEU A  54
TYR A 226
PHE A 229
 None
 1.31A 5igjA-3hjwC:
undetectable		 5igjA-3hjwC:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 PRO B1016
HIS B 841
LEU A 411
TYR A 377
 None
 1.12A 5igjA-3hkzB:
undetectable		 5igjA-3hkzB:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ide CAPSID PROTEIN VP2

(Infectious
pancreatic
necrosis virus) 		PF01766
(Birna_VP2) 		4 PRO A  57
LEU A 364
TYR A  68
PHE A  79
 None
 1.40A 5igjA-3ideA:
undetectable		 5igjA-3ideA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN

(Rhodobacter
sphaeroides) 		PF02126
(PTE) 		4 PRO A 104
HIS A 301
TYR A 268
PHE A 266
 None
 1.48A 5igjA-3k2gA:
undetectable		 5igjA-3k2gA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzq PUTATIVE
UNCHARACTERIZED
PROTEIN VP2116

(Vibrio
parahaemolyticus) 		PF13743
(Thioredoxin_5) 		4 PRO A 122
HIS A 113
LEU A 137
TYR A 104
 None
None
None
PG6  A 209 (-4.1A)
 1.47A 5igjA-3kzqA:
undetectable		 5igjA-3kzqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		4 PRO A   3
HIS A 282
LEU A  50
PHE A 272
 None
 1.42A 5igjA-3lpdA:
undetectable		 5igjA-3lpdA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		4 PRO A 299
HIS A 236
LEU A 115
TYR A  67
 None
None
None
AOO  A 457 (-4.7A)
 1.46A 5igjA-3lscA:
undetectable		 5igjA-3lscA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ovg AMIDOHYDROLASE

(Mycoplasma
synoviae) 		PF02126
(PTE) 		4 HIS A 214
LEU A 169
TYR A 105
PHE A 104
 ZN  A 363 (-3.5A)
None
None
None
 1.47A 5igjA-3ovgA:
undetectable		 5igjA-3ovgA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psg PEPSINOGEN

(Sus scrofa) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		4 PRO A   5
HIS A  53
LEU A  38
PHE A  15
 None
 1.42A 5igjA-3psgA:
undetectable		 5igjA-3psgA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdq 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Clostridium
aminobutyricum) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 PRO A 184
HIS A  31
TYR A  66
PHE A  77
 None
 1.46A 5igjA-3qdqA:
undetectable		 5igjA-3qdqA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PRO A 229
LEU A 141
TYR A  72
PHE A  71
 None
 1.37A 5igjA-3r44A:
undetectable		 5igjA-3r44A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 PRO A 300
HIS A 498
LEU A 410
PHE A 331
 None
FAD  A 773 (-4.4A)
None
None
 1.43A 5igjA-3redA:
undetectable		 5igjA-3redA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0j TYPE III EFFECTOR
HOPU1

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 4 PRO B 239
HIS B 141
TYR B  78
PHE B  66
 None
 1.47A 5igjA-3u0jB:
undetectable		 5igjA-3u0jB:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsc PROTEIN CYSO

(Aeropyrum
pernix) 		PF00291
(PALP) 		4 PRO A  96
HIS A 234
LEU A  29
TYR A  51
 None
 1.48A 5igjA-3vscA:
undetectable		 5igjA-3vscA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae) 		PF00291
(PALP) 		4 PRO A 291
HIS A 217
LEU A 239
PHE A 226
 PLP  A 401 (-4.1A)
None
None
None
 1.20A 5igjA-3x43A:
undetectable		 5igjA-3x43A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		4 HIS A1919
LEU A2077
TYR A2064
PHE A2061
 None
 1.11A 5igjA-4asiA:
undetectable		 5igjA-4asiA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bla MALTOSE-BINDING
PERIPLASMIC PROTEIN,
SUPPRESSOR OF FUSED
HOMOLOG

(Escherichia
coli;
Homo sapiens) 		PF05076
(SUFU)
PF12470
(SUFU_C)
PF13416
(SBP_bac_8) 		4 PRO A 474
HIS A 429
LEU A 484
PHE A 433
 None
 1.41A 5igjA-4blaA:
undetectable		 5igjA-4blaA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bz7 HISTONE DEACETYLASE
8

(Schistosoma
mansoni) 		PF00850
(Hist_deacetyl) 		4 HIS A 142
LEU A  97
TYR A 110
PHE A  21
 B3N  A 700 (-3.7A)
None
None
None
 1.46A 5igjA-4bz7A:
undetectable		 5igjA-4bz7A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 PRO A 315
HIS A 184
LEU A 249
PHE A 269
 None
ZN  A1003 (-3.6A)
None
None
 1.38A 5igjA-4eo4A:
undetectable		 5igjA-4eo4A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezi UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 PRO A 222
HIS A 327
TYR A 157
PHE A 251
 None
None
None
PEG  A 501 (-4.6A)
 1.37A 5igjA-4eziA:
undetectable		 5igjA-4eziA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 PRO A 554
LEU A 421
TYR A 415
PHE A 379
 None
 1.45A 5igjA-4f99A:
8.3		 5igjA-4f99A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM

(Sulfolobus
solfataricus) 		no annotation 4 PRO B 104
LEU B  74
TYR B  30
PHE B  21
 None
 1.28A 5igjA-4fdgB:
undetectable		 5igjA-4fdgB:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvl MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
thermoresistibile) 		PF00082
(Peptidase_S8) 		4 PRO A 289
LEU A 278
TYR A 339
PHE A 335
 None
 1.39A 5igjA-4hvlA:
undetectable		 5igjA-4hvlA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 PRO A 619
HIS A 497
LEU A 552
PHE A 572
 None
ZN  A 801 ( 3.3A)
None
None
 1.32A 5igjA-4hwtA:
undetectable		 5igjA-4hwtA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifs FACT COMPLEX SUBUNIT
SSRP1

(Homo sapiens) 		PF08512
(Rtt106) 		4 PRO A 366
LEU A 205
TYR A 232
PHE A 230
 None
 1.50A 5igjA-4ifsA:
undetectable		 5igjA-4ifsA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgb PUTATIVE EXPORTED
PROTEIN

(Burkholderia
pseudomallei) 		PF13460
(NAD_binding_10) 		4 PRO A  71
LEU A 172
TYR A 209
PHE A 165
 SO4  A 302 (-3.1A)
None
None
None
 1.37A 5igjA-4jgbA:
undetectable		 5igjA-4jgbA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 PRO A 205
LEU A 108
TYR A 252
PHE A 141
 None
None
None
GOL  A 301 (-4.0A)
 1.34A 5igjA-4kcdA:
undetectable		 5igjA-4kcdA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		4 PRO A 289
LEU A 278
TYR A 339
PHE A 335
 None
 1.47A 5igjA-4kpgA:
undetectable		 5igjA-4kpgA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4
R-SPONDIN-1

(Homo sapiens;
Xenopus
tropicalis) 		PF13516
(LRR_6)
PF13855
(LRR_8)
PF15913
(Furin-like_2) 		4 PRO B  89
HIS A 210
LEU A 240
TYR A 283
 None
 1.39A 5igjA-4li2B:
undetectable		 5igjA-4li2B:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		4 PRO A 289
LEU A 278
TYR A 339
PHE A 335
 None
 1.45A 5igjA-4m1zA:
undetectable		 5igjA-4m1zA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q65 DIPEPTIDE PERMEASE D

(Escherichia
coli) 		PF00854
(PTR2) 		4 PRO A 155
LEU A 107
TYR A 114
PHE A 117
 None
 1.20A 5igjA-4q65A:
undetectable		 5igjA-4q65A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
R-SPONDIN-2

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8)
PF15913
(Furin-like_2) 		4 PRO B  88
HIS A 216
LEU A 246
TYR A 289
 None
 1.43A 5igjA-4ufsB:
undetectable		 5igjA-4ufsB:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE

(Agrobacterium
tumefaciens) 		PF00701
(DHDPS) 		4 PRO A 111
LEU A  15
TYR A 202
PHE A 198
 None
 1.37A 5igjA-4ur8A:
undetectable		 5igjA-4ur8A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v20 CELLOBIOHYDROLASE

(Aspergillus
fumigatus) 		PF00840
(Glyco_hydro_7) 		4 PRO A 177
HIS A 206
LEU A  73
TYR A  51
 None
None
PCA  A   1 ( 4.5A)
None
 1.47A 5igjA-4v20A:
undetectable		 5igjA-4v20A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dld UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Burkholderia
vietnamiensis) 		PF02350
(Epimerase_2) 		4 HIS A 247
LEU A  48
TYR A 274
PHE A 277
 UD1  A 502 (-4.0A)
None
UDP  A 501 (-4.4A)
UDP  A 501 (-3.6A)
 1.15A 5igjA-5dldA:
undetectable		 5igjA-5dldA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo6 COPROPORPHYRINOGEN
OXIDASE

(Acinetobacter
baumannii) 		PF01218
(Coprogen_oxidas) 		4 PRO A 278
HIS A 115
LEU A 303
TYR A 256
 None
ACT  A 400 (-3.1A)
None
None
 1.36A 5igjA-5eo6A:
undetectable		 5igjA-5eo6A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5feb SODIUM CHANNEL
SUBUNIT BETA-2

(Homo sapiens) 		PF07686
(V-set) 		4 PRO A  35
HIS A 139
LEU A  81
TYR A  69
 None
 1.12A 5igjA-5febA:
undetectable		 5igjA-5febA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 PRO A 725
LEU A 641
TYR A 670
PHE A 674
 None
 1.41A 5igjA-5gz4A:
0.3		 5igjA-5gz4A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE

(Medicago
truncatula) 		PF00795
(CN_hydrolase) 		4 HIS A 206
LEU A  45
TYR A 119
PHE A 143
 None
 1.31A 5igjA-5h8kA:
undetectable		 5igjA-5h8kA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hax NUCLEOPORIN NUP170

(Chaetomium
thermophilum) 		PF08801
(Nucleoporin_N) 		4 PRO A 556
LEU A 678
TYR A 605
PHE A 601
 None
 1.32A 5igjA-5haxA:
3.2		 5igjA-5haxA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hss LINALOOL
DEHYDRATASE/ISOMERAS
E

(Castellaniella
defragrans) 		no annotation 4 PRO A 364
HIS A 194
LEU A 131
TYR A 145
 None
 1.41A 5igjA-5hssA:
undetectable		 5igjA-5hssA:
22.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E

(Escherichia
coli) 		PF01636
(APH) 		5 PRO A 112
HIS A 205
LEU A 270
TYR A 277
PHE A 280
 ERY  A 402 ( 4.1A)
GDP  A 401 (-4.4A)
None
ERY  A 402 ( 4.5A)
ERY  A 402 ( 3.6A)
 0.18A 5igjA-5igpA:
48.1		 5igjA-5igpA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		4 PRO A 838
LEU A 860
TYR A 811
PHE A 628
 None
 1.43A 5igjA-5kdxA:
undetectable		 5igjA-5kdxA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C1,
MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2

(Bos taurus) 		PF00329
(Complex1_30kDa)
PF00346
(Complex1_49kDa) 		4 PRO d  52
HIS c   9
LEU c  21
TYR d  64
 None
 1.28A 5igjA-5lc5d:
undetectable		 5igjA-5lc5d:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 PRO X 124
HIS X 111
TYR X 310
PHE X 312
 None
DQP  X 402 ( 4.1A)
None
DQP  X 402 (-4.9A)
 1.38A 5igjA-5liyX:
undetectable		 5igjA-5liyX:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 PRO A  77
HIS A 434
TYR A 369
PHE A 362
 None
 1.17A 5igjA-5m8tA:
undetectable		 5igjA-5m8tA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhf MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Mus musculus) 		no annotation 4 PRO A 249
HIS A 159
LEU A 117
PHE A 155
 None
 1.28A 5igjA-5mhfA:
1.0		 5igjA-5mhfA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thm ESTERASE-6

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 PRO A 220
HIS A 445
LEU A 327
TYR A 273
 None
7BZ  A 601 (-3.8A)
None
None
 1.10A 5igjA-5thmA:
undetectable		 5igjA-5thmA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uh0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F

(Yersinia pestis) 		PF00497
(SBP_bac_3) 		4 PRO A  86
LEU A 209
TYR A 264
PHE A  66
 None
 1.30A 5igjA-5uh0A:
undetectable		 5igjA-5uh0A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujz SCFV

(Homo sapiens) 		PF07686
(V-set) 		4 PRO G  45
HIS G 160
LEU G  34
TYR G 236
 None
 1.40A 5igjA-5ujzG:
undetectable		 5igjA-5ujzG:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ums FACT COMPLEX SUBUNIT
SSRP1

(Homo sapiens) 		no annotation 4 PRO A 366
LEU A 205
TYR A 232
PHE A 230
 None
 1.48A 5igjA-5umsA:
undetectable		 5igjA-5umsA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkq NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L

(Drosophila
melanogaster) 		PF00023
(Ank)
PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4) 		4 PRO A1080
HIS A1056
LEU A1036
TYR A1011
 None
 1.49A 5igjA-5vkqA:
undetectable		 5igjA-5vkqA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3v APOBEC3H

(Macaca
nemestrina) 		no annotation 4 PRO B  36
LEU B  47
TYR B  79
PHE B 107
 None
 1.13A 5igjA-5w3vB:
undetectable		 5igjA-5w3vB:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN

(Pyrococcus
horikoshii) 		no annotation 4 PRO A 281
LEU A 211
TYR A 324
PHE A 319
 None
 1.30A 5igjA-5x09A:
undetectable		 5igjA-5x09A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xev XAA-PRO
DIPEPTIDASE,PEPTIDAS
E-RELATED PROTEIN

(Deinococcus
radiodurans) 		no annotation 4 PRO A  83
LEU A  36
TYR A  23
PHE A  25
 None
None
None
CL  A 505 ( 4.8A)
 1.48A 5igjA-5xevA:
undetectable		 5igjA-5xevA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4u -

(-) 		no annotation 4 PRO A 171
LEU A 248
TYR A 221
PHE A 226
 None
 1.17A 5igjA-5y4uA:
undetectable		 5igjA-5y4uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy0 CYTOSOLIC
NIFE-HYDROGENASE,
ALPHA SUBUNIT

(Thermococcus
kodakarensis) 		no annotation 4 PRO A 377
HIS A 111
LEU A 276
PHE A 304
 None
 1.40A 5igjA-5yy0A:
undetectable		 5igjA-5yy0A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bms PALMITOYLTRANSFERASE

(Danio rerio) 		no annotation 4 HIS A 142
LEU A 137
TYR A 155
PHE A 158
 ZN  A1002 ( 3.1A)
None
None
PLM  A1006 (-4.7A)
 1.42A 5igjA-6bmsA:
2.0		 5igjA-6bmsA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6u -

(-) 		no annotation 4 PRO N 100
LEU N  26
TYR N  68
PHE N  65
 None
 1.37A 5igjA-6c6uN:
undetectable		 5igjA-6c6uN:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0y NUCLEAR CAP-BINDING
PROTEIN SUBUNIT 2

(Homo sapiens) 		no annotation 4 HIS A  24
LEU A  36
TYR A  43
PHE A  83
 None
None
GTA  A 201 (-3.4A)
GTA  A 201 (-3.7A)
 1.40A 5igjA-6d0yA:
undetectable		 5igjA-6d0yA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6df3 -

(-) 		no annotation 4 HIS C 167
LEU C 151
TYR C 116
PHE C 115
 None
 1.22A 5igjA-6df3C:
undetectable		 5igjA-6df3C:
undetectable