SIMILAR PATTERNS OF AMINO ACIDS FOR 5IGJ_A_CTYA402_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2o CHEB METHYLESTERASE

(Salmonella
enterica) 		PF00072
(Response_reg)
PF01339
(CheB_methylest) 		5 ILE A 135
VAL A  52
MET A  81
VAL A  80
GLY A  64
 None
 1.09A 5igjA-1a2oA:
0.0		 5igjA-1a2oA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (ALPHA
SUBUNIT)

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		5 ILE A 154
VAL A 179
GLU A 385
ALA A 195
VAL A 192
 None
 1.01A 5igjA-1a6dA:
0.0		 5igjA-1a6dA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpw CALCIUM-BINDING
PROTEIN NCS-1

(Saccharomyces
cerevisiae) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		5 MET A 121
ILE A 116
ASP A 187
VAL A 125
ALA A 182
 None
CA  A 501 (-4.6A)
None
None
None
 0.98A 5igjA-1fpwA:
undetectable		 5igjA-1fpwA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hrd GLUTAMATE
DEHYDROGENASE

([Clostridium]
symbiosum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 ILE A  53
ASP A  17
TYR A  15
VAL A  11
VAL A  25
 None
 1.01A 5igjA-1hrdA:
0.0		 5igjA-1hrdA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ia7 CELLULASE CEL9M

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9) 		5 ASP A 414
ALA A 311
ALA A 312
MET A 315
VAL A 316
 SO4  A1335 ( 4.3A)
None
None
None
None
 1.11A 5igjA-1ia7A:
undetectable		 5igjA-1ia7A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3t CYTIDYLATE KINASE

(Streptococcus
pneumoniae) 		PF02224
(Cytidylate_kin) 		5 VAL A 121
GLU A 131
ALA A  53
ALA A  54
GLY A  95
 None
 0.86A 5igjA-1q3tA:
0.0		 5igjA-1q3tA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgc PROTEIN (VIRUS
CAPSID PROTEIN VP1)
PROTEIN (VIRUS
CAPSID PROTEIN VP2)

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		5 ILE 2 197
VAL 2 109
VAL 2 123
GLY 1   5
THR 1   4
 None
 1.01A 5igjA-1qgc2:
0.0		 5igjA-1qgc2:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qy9 HYPOTHETICAL PROTEIN
YDDE

(Escherichia
coli) 		PF02567
(PhzC-PhzF) 		5 ILE A  60
VAL A  82
GLU A 108
ALA A 285
VAL A   8
 None
 0.92A 5igjA-1qy9A:
0.0		 5igjA-1qy9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si1 IRON BINDING PROTEIN
FBPA

(Mannheimia
haemolytica) 		PF13343
(SBP_bac_6) 		5 ILE A 194
ALA A 303
ALA A 304
VAL A 308
GLY A 155
 None
 0.68A 5igjA-1si1A:
0.0		 5igjA-1si1A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN

(Aquifex
aeolicus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ILE A  51
VAL A  29
ALA A  74
VAL A  72
GLY A  98
 None
 0.96A 5igjA-1ulzA:
undetectable		 5igjA-1ulzA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfw PROTEIN (FUSION
PROTEIN CONSISTING
OF KINESIN-LIKE
PROTEIN KIF1A,
KINESIN HEAVY CHAIN
ISOFORM 5C AND A HIS
TAG

(Mus musculus) 		PF00225
(Kinesin) 		5 ILE A 354
VAL A   8
ALA A 330
ALA A 329
GLY A 251
 None
None
None
None
ANP  A 500 (-3.4A)
 1.02A 5igjA-1vfwA:
undetectable		 5igjA-1vfwA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5d PENICILLIN-BINDING
PROTEIN

(Bacillus
subtilis) 		PF02113
(Peptidase_S13) 		5 ASP A 105
ALA A 249
ALA A 159
GLY A  95
THR A  74
 None
 1.00A 5igjA-1w5dA:
undetectable		 5igjA-1w5dA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anp LEUCYL
AMINOPEPTIDASE

(Vibrio
proteolyticus) 		PF04389
(Peptidase_M28) 		5 GLU A 245
ALA A 123
ALA A 124
VAL A 128
GLY A 269
 None
 0.89A 5igjA-2anpA:
undetectable		 5igjA-2anpA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2au1 IGG-DEGRADING
PROTEASE

(Streptococcus
pyogenes) 		PF09028
(Mac-1) 		5 GLU A 154
ALA A  97
ALA A  96
VAL A 171
THR A  85
 None
 1.10A 5igjA-2au1A:
undetectable		 5igjA-2au1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cq1 PTB-LIKE PROTEIN L

(Homo sapiens) 		no annotation 5 ALA A 106
ALA A 107
MET A 110
VAL A 111
THR A  86
 None
 0.57A 5igjA-2cq1A:
2.0		 5igjA-2cq1A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq3 SERYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		5 ILE A 276
ASP A 336
VAL A 339
ALA A 306
GLY A 384
 None
None
None
None
SSA  A1001 (-3.7A)
 1.07A 5igjA-2dq3A:
0.1		 5igjA-2dq3A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG

(Thermus
thermophilus) 		PF05690
(ThiG) 		5 VAL A 196
ALA A 154
ALA A 153
VAL A 183
GLY A 157
 None
 1.06A 5igjA-2htmA:
undetectable		 5igjA-2htmA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id1 HYPOTHETICAL PROTEIN

(Chromobacterium
violaceum) 		PF02410
(RsfS) 		5 VAL A  80
GLU A  76
ALA A  50
ALA A  52
VAL A  55
 None
 1.10A 5igjA-2id1A:
undetectable		 5igjA-2id1A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ldx APO-LACTATE
DEHYDROGENASE

(Mus musculus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A 199
VAL A 303
VAL A 269
GLY A 159
THR A 143
 None
 1.10A 5igjA-2ldxA:
undetectable		 5igjA-2ldxA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m5y PUTATIVE TUBERCULIN
RELATED PEPTIDE

(Mycobacterium
tuberculosis) 		PF13399
(LytR_C) 		5 VAL A 118
GLU A 108
ALA A  91
VAL A  94
GLY A  86
 None
 1.02A 5igjA-2m5yA:
undetectable		 5igjA-2m5yA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mki CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 4

(Homo sapiens) 		PF16367
(RRM_7) 		5 VAL A 250
ALA A 230
ALA A 231
VAL A 237
GLY A 199
 None
 1.06A 5igjA-2mkiA:
undetectable		 5igjA-2mkiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n3o POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 1

(Homo sapiens) 		no annotation 6 GLU A 135
ALA A 106
ALA A 107
MET A 110
VAL A 111
THR A  86
 None
 1.02A 5igjA-2n3oA:
1.1		 5igjA-2n3oA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obn HYPOTHETICAL PROTEIN

(Trichormus
variabilis) 		PF07755
(DUF1611)
PF17396
(DUF1611_N) 		5 ILE A 129
VAL A  75
GLU A  66
ALA A  38
ALA A  10
 None
 1.10A 5igjA-2obnA:
undetectable		 5igjA-2obnA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE

(Staphylococcus
aureus) 		PF13378
(MR_MLE_C) 		5 ILE A  34
VAL A 104
ALA A  85
ALA A  86
VAL A  90
 None
 0.99A 5igjA-2olaA:
undetectable		 5igjA-2olaA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ols PHOSPHOENOLPYRUVATE
SYNTHASE

(Neisseria
meningitidis) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		5 ALA A  46
ALA A 188
VAL A 124
GLY A  21
THR A 129
 None
 1.07A 5igjA-2olsA:
undetectable		 5igjA-2olsA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ovl PUTATIVE RACEMASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 109
VAL A  36
ALA A  61
VAL A  64
GLY A  56
 None
 1.01A 5igjA-2ovlA:
undetectable		 5igjA-2ovlA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A1200
ALA A1587
ALA A1382
VAL A1027
GLY A1248
 None
 1.06A 5igjA-2pffA:
undetectable		 5igjA-2pffA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A1200
ALA A1587
ALA A1382
VAL A1027
GLY A1330
 None
 1.06A 5igjA-2pffA:
undetectable		 5igjA-2pffA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Vibrio cholerae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 ILE A 107
VAL A  93
ALA A   9
ALA A  71
GLY A  12
 None
 1.00A 5igjA-2qz9A:
undetectable		 5igjA-2qz9A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr2 DIHYDROPYRIMIDINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 ASP A  17
TYR A 389
ALA A 382
ALA A 383
GLY A  63
 None
 1.10A 5igjA-2vr2A:
undetectable		 5igjA-2vr2A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ILE A 214
VAL A 157
ALA A 290
VAL A 309
GLY A 316
 None
 1.02A 5igjA-2xf8A:
undetectable		 5igjA-2xf8A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CYTOCHROME C OXIDASE
SUBUNIT 2

(Thermus
thermophilus) 		PF00034
(Cytochrom_C)
PF00115
(COX1)
PF00116
(COX2)
PF00510
(COX3)
PF02790
(COX2_TM) 		5 ILE B 161
ALA A 214
ALA A 215
VAL A 219
GLY A 638
 None
 0.74A 5igjA-2yevB:
undetectable		 5igjA-2yevB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE

(Lactobacillus
delbrueckii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ILE A  84
VAL A  49
ALA A 322
VAL A  71
GLY A 325
 None
 1.09A 5igjA-2yq4A:
undetectable		 5igjA-2yq4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzj GLUCURONAN LYASE A

(Trichoderma
reesei) 		PF14099
(Polysacc_lyase) 		5 ILE A 112
TYR A 221
VAL A 197
ALA A  37
VAL A 224
 None
 1.10A 5igjA-2zzjA:
undetectable		 5igjA-2zzjA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akf PUTATIVE SECRETED
ALPHA
L-ARABINOFURANOSIDAS
E II

(Streptomyces
avermitilis) 		PF04616
(Glyco_hydro_43)
PF05270
(AbfB) 		5 ILE A  83
TYR A  90
VAL A  89
ALA A  77
GLY A 197
 None
None
None
GOL  A 591 ( 4.4A)
NA  A 502 ( 4.7A)
 0.99A 5igjA-3akfA:
undetectable		 5igjA-3akfA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8l FTSZ-LIKE PROTEIN OF
UNKNOWN FUNCTION

(Nostoc
punctiforme) 		PF09585
(Lin0512_fam) 		5 GLU A  65
ALA A  24
ALA A  25
VAL A  29
GLY A  89
 None
 0.80A 5igjA-3c8lA:
undetectable		 5igjA-3c8lA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX

(Escherichia
coli) 		PF03320
(FBPase_glpX) 		5 ILE A  53
ASP A  33
ALA A  17
ALA A  16
VAL A  12
 None
CA  A 337 (-2.7A)
None
None
None
 0.96A 5igjA-3d1rA:
undetectable		 5igjA-3d1rA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN

(Pyrococcus
furiosus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		5 ILE A 102
VAL A 133
GLU A 164
ALA A 143
VAL A 117
 None
 1.05A 5igjA-3dm5A:
undetectable		 5igjA-3dm5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e53 FATTY-ACID-COA
LIGASE FADD28

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		5 ILE A 457
ASP A 222
VAL A 338
ALA A 411
VAL A 405
 None
 1.05A 5igjA-3e53A:
undetectable		 5igjA-3e53A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk3 PROTEIN AF-9 HOMOLOG

(Saccharomyces
cerevisiae) 		PF03366
(YEATS) 		5 ILE A 153
ASP A  54
VAL A  47
ALA A  79
VAL A  62
 None
 1.03A 5igjA-3fk3A:
undetectable		 5igjA-3fk3A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF02738
(Ald_Xan_dh_C2) 		5 ILE B  30
VAL B  38
ALA B  25
ALA B  26
VAL B  97
 None
 1.00A 5igjA-3hrdB:
undetectable		 5igjA-3hrdB:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6d PROTOPORPHYRINOGEN
OXIDASE

(Bacillus
subtilis) 		PF01593
(Amino_oxidase) 		5 VAL A 314
ALA A 344
VAL A 387
GLY A 331
THR A 330
 None
 0.96A 5igjA-3i6dA:
undetectable		 5igjA-3i6dA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juj UDP-GLUCOSE
PYROPHOSPHORYLASE
(GALU)

(Helicobacter
pylori) 		PF00483
(NTP_transferase) 		5 ILE A 230
ALA A  10
VAL A  54
GLY A  13
THR A  14
 None
 1.10A 5igjA-3jujA:
undetectable		 5igjA-3jujA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2z BIRA BIFUNCTIONAL
PROTEIN

(Mycobacterium
tuberculosis) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		5 ILE A  59
VAL A 155
ALA A 104
ALA A 105
VAL A 109
 None
 0.90A 5igjA-3l2zA:
undetectable		 5igjA-3l2zA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES

(Arabidopsis
thaliana) 		PF01048
(PNP_UDP_1) 		5 ASP A 179
ALA A 204
ALA A 205
VAL A 209
GLY A 152
 None
 1.06A 5igjA-3lgsA:
undetectable		 5igjA-3lgsA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhi D7 PROTEIN

(Anopheles
stephensi) 		PF01395
(PBP_GOBP) 		5 ILE A  75
TYR A 117
VAL A 120
ALA A 116
GLY A 108
 None
EAH  A   1 (-4.6A)
None
None
None
 1.10A 5igjA-3nhiA:
undetectable		 5igjA-3nhiA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkg PROTEIN AMBP

(Homo sapiens) 		PF00061
(Lipocalin) 		5 MET A 163
ILE A  30
VAL A  46
GLU A  74
GLY A  23
 None
 1.09A 5igjA-3qkgA:
undetectable		 5igjA-3qkgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhg PUTATIVE
PHOPHOTRIESTERASE

(Proteus
mirabilis) 		PF02126
(PTE) 		5 ILE A  74
ALA A 161
ALA A 121
VAL A 119
GLY A 153
 None
 1.03A 5igjA-3rhgA:
undetectable		 5igjA-3rhgA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t12 GLIDING PROTEIN MGLB

(Thermus
thermophilus) 		PF03259
(Robl_LC7) 		5 VAL B  96
GLU B 101
ALA B  68
ALA B  67
VAL B  63
 None
 1.05A 5igjA-3t12B:
undetectable		 5igjA-3t12B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3toe DNA/RNA-BINDING
PROTEIN ALBA

(Methanothermobacter
thermautotrophicus) 		PF01918
(Alba) 		5 ILE A  61
ASP A  46
VAL A  51
VAL A  21
GLY A  10
 None
 1.10A 5igjA-3toeA:
undetectable		 5igjA-3toeA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti) 		PF00294
(PfkB) 		5 ILE A 211
VAL A   6
ALA A  65
VAL A  68
GLY A  59
 None
None
None
None
ADN  A 353 (-3.2A)
 1.08A 5igjA-3uboA:
undetectable		 5igjA-3uboA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vs8 TYPE III POLYKETIDE
SYNTHASE

(Azotobacter
vinelandii) 		PF02797
(Chal_sti_synt_C) 		5 VAL A 178
ALA A 164
MET A 167
VAL A 168
GLY A 135
 None
 0.98A 5igjA-3vs8A:
undetectable		 5igjA-3vs8A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w25 GLYCOSIDE HYDROLASE
FAMILY 10

(Thermoanaerobacterium
saccharolyticum) 		PF00331
(Glyco_hydro_10) 		5 MET A 201
ILE A 191
VAL A 205
VAL A 245
GLY A 140
 None
 1.08A 5igjA-3w25A:
undetectable		 5igjA-3w25A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A2015
GLU A1990
ALA A1998
MET A2001
GLY A2104
 None
 1.03A 5igjA-3zbfA:
6.8		 5igjA-3zbfA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00348
(polyprenyl_synt) 		5 ILE A   2
VAL A 291
ALA A 217
GLY A 182
THR A 181
 6H6  A1299 ( 4.1A)
None
None
None
None
 1.07A 5igjA-3zouA:
undetectable		 5igjA-3zouA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 ILE A 193
VAL A 463
GLU A 530
MET A 442
VAL A 445
 None
 1.00A 5igjA-4am3A:
undetectable		 5igjA-4am3A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		5 ILE A 706
ALA A 443
ALA A 444
MET A 447
GLY A 427
 None
 1.10A 5igjA-4av6A:
undetectable		 5igjA-4av6A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Thermobispora
bispora) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A  88
VAL A  84
ALA A  62
ALA A  61
VAL A 108
 None
 1.04A 5igjA-4dhgA:
undetectable		 5igjA-4dhgA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e09 PLASMID PARTITIONING
PROTEIN PARF

(Escherichia
coli) 		PF01656
(CbiA) 		5 ILE A 102
VAL A  19
GLU A 195
VAL A  35
GLY A  30
 None
 1.09A 5igjA-4e09A:
undetectable		 5igjA-4e09A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3a SUGAR KINASE PROTEIN

(Rhizobium etli) 		PF00294
(PfkB) 		5 ILE A 209
VAL A   4
ALA A  63
VAL A  66
GLY A  57
 None
None
None
None
ADN  A 500 (-3.7A)
 1.07A 5igjA-4e3aA:
undetectable		 5igjA-4e3aA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gh4 CAPSID PROTEIN VP1
CAPSID PROTEIN VP2

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		5 ILE B 197
VAL B 109
VAL B 123
GLY A   5
THR A   4
 None
 1.04A 5igjA-4gh4B:
undetectable		 5igjA-4gh4B:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxy PLM1

(Streptomyces
sp. HK803) 		PF08659
(KR) 		5 VAL A  57
GLU A  30
ALA A  69
ALA A  70
VAL A  74
 None
 0.95A 5igjA-4hxyA:
undetectable		 5igjA-4hxyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6j F-BOX/LRR-REPEAT
PROTEIN 3

(Homo sapiens) 		PF12937
(F-box-like) 		5 ILE B 392
VAL B 380
GLU B 349
ALA B 355
GLY B 328
 None
 0.89A 5igjA-4i6jB:
undetectable		 5igjA-4i6jB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv6 ACYL-COA
DEHYDROGENASE FADE3

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ILE A 359
ASP A 332
ALA A 256
VAL A 252
GLY A 288
 None
 1.06A 5igjA-4iv6A:
undetectable		 5igjA-4iv6A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqk NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Salmonella
enterica) 		PF02277
(DBI_PRT) 		5 ILE A 137
GLU A 149
ALA A 274
ALA A 273
GLY A 248
 None
 0.99A 5igjA-4kqkA:
undetectable		 5igjA-4kqkA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lx4 ENDOGLUCANASE(ENDO-1
,4-BETA-GLUCANASE)PR
OTEIN

(Pseudomonas
stutzeri) 		PF00150
(Cellulase) 		5 ILE A 202
ALA A 155
ALA A 156
VAL A 160
GLY A 102
 None
 0.82A 5igjA-4lx4A:
undetectable		 5igjA-4lx4A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mch URIDINE
PHOSPHORYLASE

(Aliivibrio
fischeri) 		PF01048
(PNP_UDP_1) 		5 ILE A  60
VAL A  85
GLU A 135
ALA A 128
ALA A 197
 None
 1.08A 5igjA-4mchA:
undetectable		 5igjA-4mchA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE

(Lactobacillus
casei) 		PF01408
(GFO_IDH_MocA) 		5 ILE A  67
ALA A  40
ALA A  41
VAL A  45
GLY A  11
 None
NAI  A 401 ( 4.5A)
None
None
NAI  A 401 (-3.3A)
 1.07A 5igjA-4mioA:
undetectable		 5igjA-4mioA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2w E3 UBIQUITIN-PROTEIN
LIGASE HERC1

(Homo sapiens) 		PF00415
(RCC1) 		5 VAL A4296
ALA A4192
ALA A4245
VAL A4252
GLY A4142
 None
 1.09A 5igjA-4o2wA:
undetectable		 5igjA-4o2wA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o3s DNA POLYMERASE ETA

(Homo sapiens) 		PF00817
(IMS)
PF11799
(IMS_C) 		5 MET A 200
ILE A 196
ALA A 112
ALA A 117
VAL A  12
 None
 0.94A 5igjA-4o3sA:
undetectable		 5igjA-4o3sA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4olo BMC DOMAIN PROTEIN

(Clostridiales
bacterium
1_7_47FAA) 		PF00936
(BMC) 		5 ILE A  63
GLU A  84
ALA A  55
ALA A  52
GLY A  57
 None
 1.09A 5igjA-4oloA:
undetectable		 5igjA-4oloA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB

(Escherichia
coli) 		PF07244
(POTRA)
PF13360
(PQQ_2) 		5 ILE A1390
ALA A1075
ALA A1074
VAL A1072
GLY A1053
 None
 1.10A 5igjA-4pk1A:
undetectable		 5igjA-4pk1A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvg SIBL

(Streptosporangium
sibiricum) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 TYR A 134
ALA A 139
ALA A 138
GLY A 128
THR A 129
 None
 1.05A 5igjA-4qvgA:
undetectable		 5igjA-4qvgA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r27 GLYCOSIDE HYDROLASE

(Microbacterium
sp. Gsoil167) 		PF00232
(Glyco_hydro_1) 		5 ILE A 389
GLU A 141
ALA A 202
ALA A 201
GLY A 193
 None
 1.01A 5igjA-4r27A:
undetectable		 5igjA-4r27A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru4 TAIL SPIKE PROTEIN
GP49

(Pseudomonas
virus LKA1) 		PF13229
(Beta_helix) 		5 TYR A 318
VAL A 470
GLU A 336
ALA A 364
GLY A 360
 None
 1.05A 5igjA-4ru4A:
undetectable		 5igjA-4ru4A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y96 TRIOSEPHOSPHATE
ISOMERASE

(Gemmata
obscuriglobus) 		PF00121
(TIM) 		5 ILE A 250
ALA A 190
ALA A 187
VAL A 232
GLY A 132
 None
 0.97A 5igjA-4y96A:
undetectable		 5igjA-4y96A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxs VIRION EGRESS
PROTEIN UL31

(Human
alphaherpesvirus
1) 		PF02718
(Herpes_UL31) 		5 MET B 234
ILE B 231
VAL B 188
VAL B 256
THR B 251
 None
NA  B 402 (-3.8A)
None
None
None
 0.90A 5igjA-4zxsB:
0.8		 5igjA-4zxsB:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5l D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE

(Thermosynechococcus
elongatus) 		PF03320
(FBPase_glpX) 		5 ILE A  53
ASP A  33
ALA A  17
ALA A  16
VAL A  12
 None
MG  A1341 (-3.3A)
None
None
None
 1.08A 5igjA-5a5lA:
undetectable		 5igjA-5a5lA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8d CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF04616
(Glyco_hydro_43) 		5 MET A 310
ILE A 318
ALA A  45
ALA A 274
GLY A 168
 None
None
GOL  A1340 (-3.6A)
GOL  A1340 (-3.0A)
GOL  A1340 (-3.3A)
 1.09A 5igjA-5a8dA:
undetectable		 5igjA-5a8dA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5coa IRIDOID SYNTHASE

(Catharanthus
roseus) 		no annotation 5 ILE A 145
GLU A 256
ALA A 267
VAL A 271
GLY A 363
 None
 1.08A 5igjA-5coaA:
undetectable		 5igjA-5coaA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCA-B

(synthetic
construct) 		PF00291
(PALP) 		5 ASP B 326
ALA B 266
ALA B 265
GLY B 262
THR B 261
 None
 1.04A 5igjA-5ey5B:
undetectable		 5igjA-5ey5B:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby SEPARASE

(Chaetomium
thermophilum) 		PF03568
(Peptidase_C50) 		5 VAL A2189
ALA A2205
ALA A2206
VAL A2139
THR A2146
 None
 1.02A 5igjA-5fbyA:
undetectable		 5igjA-5fbyA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flw EXO-BETA-1,3-GALACTA
NASE

(Bifidobacterium
bifidum) 		PF04616
(Glyco_hydro_43) 		5 ILE A 172
VAL A 113
GLU A  82
VAL A  96
GLY A  24
 None
 0.91A 5igjA-5flwA:
undetectable		 5igjA-5flwA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ica PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF04003
(Utp12)
PF08625
(Utp13) 		5 ILE B 806
GLU A 916
ALA A 922
ALA A 923
VAL A 927
 None
 1.09A 5igjA-5icaB:
undetectable		 5igjA-5icaB:
19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E

(Escherichia
coli) 		PF01636
(APH) 		12 MET A 103
ILE A 105
ASP A 200
TYR A 202
VAL A 203
GLU A 222
ALA A 233
ALA A 234
MET A 237
VAL A 238
GLY A 273
THR A 276
 ERY  A 402 (-2.2A)
ERY  A 402 ( 4.4A)
ERY  A 402 (-2.4A)
ERY  A 402 (-2.7A)
None
ERY  A 402 ( 3.9A)
ERY  A 402 ( 3.9A)
ERY  A 402 ( 3.2A)
ERY  A 402 ( 3.0A)
ERY  A 402 ( 4.7A)
ERY  A 402 ( 3.6A)
ERY  A 402 ( 3.8A)
 0.40A 5igjA-5igpA:
48.1		 5igjA-5igpA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihs ENDOGLUCANASE,
GLYCOSIDE HYDROLASE
FAMILY 5 PROTEIN

(Cytophaga
hutchinsonii) 		PF00150
(Cellulase) 		5 VAL A 156
GLU A 101
ALA A 134
ALA A 135
VAL A 177
 None
 1.07A 5igjA-5ihsA:
undetectable		 5igjA-5ihsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 ILE A 198
GLU A 100
ALA A 103
VAL A 112
GLY A 119
 None
EDO  A1007 ( 4.9A)
None
None
None
 1.05A 5igjA-5jouA:
1.1		 5igjA-5jouA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN7

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF10602
(RPN7) 		5 ILE R 271
GLU R 332
ALA R 227
ALA R 228
VAL R 232
 None
 0.98A 5igjA-5mpdR:
undetectable		 5igjA-5mpdR:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nth PUTATIVE
AMINOPEPTIDASE

(Leishmania
major) 		PF00883
(Peptidase_M17) 		5 ASP A 119
VAL A 152
ALA A 124
VAL A 142
GLY A  82
 None
 0.93A 5igjA-5nthA:
undetectable		 5igjA-5nthA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G

(Methanothermococcus
thermolithotrophicus) 		PF01058
(Oxidored_q6) 		5 ILE E   4
VAL E  79
ALA E  87
ALA E  81
GLY E 148
 None
None
ACT  E 301 (-4.3A)
ACT  E 301 ( 4.5A)
None
 0.89A 5igjA-5odrE:
undetectable		 5igjA-5odrE:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oji DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4

(Caenorhabditis
elegans) 		no annotation 5 ILE A  39
VAL A  93
GLU A 138
ALA A 238
VAL A 234
 None
 0.91A 5igjA-5ojiA:
undetectable		 5igjA-5ojiA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olc GALACTONATE
DEHYDRATASE

(Zobellia
galactanivorans) 		no annotation 5 ILE A 265
ALA A 306
ALA A 307
VAL A 311
GLY A 275
 None
 0.74A 5igjA-5olcA:
undetectable		 5igjA-5olcA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tch TRYPTOPHAN SYNTHASE
BETA CHAIN

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		5 ASP B 343
ALA B 283
ALA B 282
GLY B 279
THR B 278
 None
 1.10A 5igjA-5tchB:
undetectable		 5igjA-5tchB:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj3 ALKALINE PHOSPHATASE
PAFA

(Elizabethkingia
meningoseptica) 		PF01663
(Phosphodiest) 		5 ILE A  86
VAL A 523
GLU A 542
VAL A  32
GLY A  64
 None
 0.99A 5igjA-5tj3A:
undetectable		 5igjA-5tj3A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE

(Hypericum
androsaemum) 		no annotation 5 ILE A 313
VAL A 383
MET A 287
VAL A 286
GLY A 372
 None
 1.08A 5igjA-5ucoA:
undetectable		 5igjA-5ucoA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE

(Streptomyces
peucetius) 		no annotation 6 ASP A 302
VAL A 164
ALA A 166
MET A 149
GLY A 146
THR A 145
 None
 1.33A 5igjA-5wgcA:
undetectable		 5igjA-5wgcA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6amz 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E

(Acinetobacter
baumannii) 		PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2) 		5 ILE A 178
VAL A 227
ALA A 249
ALA A 250
VAL A 233
 None
 1.08A 5igjA-6amzA:
undetectable		 5igjA-6amzA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT C
ALTERNATIVE COMPLEX
III SUBUNIT D

(Flavobacterium
johnsoniae) 		no annotation 5 VAL C 177
ALA D 111
ALA D 112
MET D 115
VAL D 116
 None
 0.96A 5igjA-6btmC:
undetectable		 5igjA-6btmC:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ch3 FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Salmonella
enterica) 		no annotation 6 MET A 365
ILE A 420
VAL A 367
MET A 374
VAL A 375
GLY A 435
 None
 1.43A 5igjA-6ch3A:
undetectable		 5igjA-6ch3A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fht BACTERIOPHYTOCHROME,
ADENYLATE CYCLASE

(Deinococcus
radiodurans;
Synechocystis
sp. PCC 6803) 		no annotation 5 ILE A 675
GLU A 648
ALA A 609
VAL A 613
GLY A 600
 None
 1.10A 5igjA-6fhtA:
undetectable		 5igjA-6fhtA:
11.63