SIMILAR PATTERNS OF AMINO ACIDS FOR 5IGJ_A_CTYA402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2o CHEB METHYLESTERASE

(Salmonella
enterica) 		PF00072
(Response_reg)
PF01339
(CheB_methylest) 		5 ILE A 135
VAL A  52
MET A  81
VAL A  80
GLY A  64
 None
 1.09A 5igjA-1a2oA:
0.0		 5igjA-1a2oA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (ALPHA
SUBUNIT)

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		5 ILE A 154
VAL A 179
GLU A 385
ALA A 195
VAL A 192
 None
 1.01A 5igjA-1a6dA:
0.0		 5igjA-1a6dA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpw CALCIUM-BINDING
PROTEIN NCS-1

(Saccharomyces
cerevisiae) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		5 MET A 121
ILE A 116
ASP A 187
VAL A 125
ALA A 182
 None
CA  A 501 (-4.6A)
None
None
None
 0.98A 5igjA-1fpwA:
undetectable		 5igjA-1fpwA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hrd GLUTAMATE
DEHYDROGENASE

([Clostridium]
symbiosum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 ILE A  53
ASP A  17
TYR A  15
VAL A  11
VAL A  25
 None
 1.01A 5igjA-1hrdA:
0.0		 5igjA-1hrdA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ia7 CELLULASE CEL9M

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9) 		5 ASP A 414
ALA A 311
ALA A 312
MET A 315
VAL A 316
 SO4  A1335 ( 4.3A)
None
None
None
None
 1.11A 5igjA-1ia7A:
undetectable		 5igjA-1ia7A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3t CYTIDYLATE KINASE

(Streptococcus
pneumoniae) 		PF02224
(Cytidylate_kin) 		5 VAL A 121
GLU A 131
ALA A  53
ALA A  54
GLY A  95
 None
 0.86A 5igjA-1q3tA:
0.0		 5igjA-1q3tA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgc PROTEIN (VIRUS
CAPSID PROTEIN VP1)
PROTEIN (VIRUS
CAPSID PROTEIN VP2)

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		5 ILE 2 197
VAL 2 109
VAL 2 123
GLY 1   5
THR 1   4
 None
 1.01A 5igjA-1qgc2:
0.0		 5igjA-1qgc2:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qy9 HYPOTHETICAL PROTEIN
YDDE

(Escherichia
coli) 		PF02567
(PhzC-PhzF) 		5 ILE A  60
VAL A  82
GLU A 108
ALA A 285
VAL A   8
 None
 0.92A 5igjA-1qy9A:
0.0		 5igjA-1qy9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si1 IRON BINDING PROTEIN
FBPA

(Mannheimia
haemolytica) 		PF13343
(SBP_bac_6) 		5 ILE A 194
ALA A 303
ALA A 304
VAL A 308
GLY A 155
 None
 0.68A 5igjA-1si1A:
0.0		 5igjA-1si1A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN

(Aquifex
aeolicus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ILE A  51
VAL A  29
ALA A  74
VAL A  72
GLY A  98
 None
 0.96A 5igjA-1ulzA:
undetectable		 5igjA-1ulzA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfw PROTEIN (FUSION
PROTEIN CONSISTING
OF KINESIN-LIKE
PROTEIN KIF1A,
KINESIN HEAVY CHAIN
ISOFORM 5C AND A HIS
TAG

(Mus musculus) 		PF00225
(Kinesin) 		5 ILE A 354
VAL A   8
ALA A 330
ALA A 329
GLY A 251
 None
None
None
None
ANP  A 500 (-3.4A)
 1.02A 5igjA-1vfwA:
undetectable		 5igjA-1vfwA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5d PENICILLIN-BINDING
PROTEIN

(Bacillus
subtilis) 		PF02113
(Peptidase_S13) 		5 ASP A 105
ALA A 249
ALA A 159
GLY A  95
THR A  74
 None
 1.00A 5igjA-1w5dA:
undetectable		 5igjA-1w5dA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anp LEUCYL
AMINOPEPTIDASE

(Vibrio
proteolyticus) 		PF04389
(Peptidase_M28) 		5 GLU A 245
ALA A 123
ALA A 124
VAL A 128
GLY A 269
 None
 0.89A 5igjA-2anpA:
undetectable		 5igjA-2anpA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2au1 IGG-DEGRADING
PROTEASE

(Streptococcus
pyogenes) 		PF09028
(Mac-1) 		5 GLU A 154
ALA A  97
ALA A  96
VAL A 171
THR A  85
 None
 1.10A 5igjA-2au1A:
undetectable		 5igjA-2au1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cq1 PTB-LIKE PROTEIN L

(Homo sapiens) 		no annotation 5 ALA A 106
ALA A 107
MET A 110
VAL A 111
THR A  86
 None
 0.57A 5igjA-2cq1A:
2.0		 5igjA-2cq1A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq3 SERYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		5 ILE A 276
ASP A 336
VAL A 339
ALA A 306
GLY A 384
 None
None
None
None
SSA  A1001 (-3.7A)
 1.07A 5igjA-2dq3A:
0.1		 5igjA-2dq3A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG

(Thermus
thermophilus) 		PF05690
(ThiG) 		5 VAL A 196
ALA A 154
ALA A 153
VAL A 183
GLY A 157
 None
 1.06A 5igjA-2htmA:
undetectable		 5igjA-2htmA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id1 HYPOTHETICAL PROTEIN

(Chromobacterium
violaceum) 		PF02410
(RsfS) 		5 VAL A  80
GLU A  76
ALA A  50
ALA A  52
VAL A  55
 None
 1.10A 5igjA-2id1A:
undetectable		 5igjA-2id1A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ldx APO-LACTATE
DEHYDROGENASE

(Mus musculus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A 199
VAL A 303
VAL A 269
GLY A 159
THR A 143
 None
 1.10A 5igjA-2ldxA:
undetectable		 5igjA-2ldxA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m5y PUTATIVE TUBERCULIN
RELATED PEPTIDE

(Mycobacterium
tuberculosis) 		PF13399
(LytR_C) 		5 VAL A 118
GLU A 108
ALA A  91
VAL A  94
GLY A  86
 None
 1.02A 5igjA-2m5yA:
undetectable		 5igjA-2m5yA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mki CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 4

(Homo sapiens) 		PF16367
(RRM_7) 		5 VAL A 250
ALA A 230
ALA A 231
VAL A 237
GLY A 199
 None
 1.06A 5igjA-2mkiA:
undetectable		 5igjA-2mkiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n3o POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 1

(Homo sapiens) 		no annotation 6 GLU A 135
ALA A 106
ALA A 107
MET A 110
VAL A 111
THR A  86
 None
 1.02A 5igjA-2n3oA:
1.1		 5igjA-2n3oA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obn HYPOTHETICAL PROTEIN

(Trichormus
variabilis) 		PF07755
(DUF1611)
PF17396
(DUF1611_N) 		5 ILE A 129
VAL A  75
GLU A  66
ALA A  38
ALA A  10
 None
 1.10A 5igjA-2obnA:
undetectable		 5igjA-2obnA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE

(Staphylococcus
aureus) 		PF13378
(MR_MLE_C) 		5 ILE A  34
VAL A 104
ALA A  85
ALA A  86
VAL A  90
 None
 0.99A 5igjA-2olaA:
undetectable		 5igjA-2olaA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ols PHOSPHOENOLPYRUVATE
SYNTHASE

(Neisseria
meningitidis) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		5 ALA A  46
ALA A 188
VAL A 124
GLY A  21
THR A 129
 None
 1.07A 5igjA-2olsA:
undetectable		 5igjA-2olsA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ovl PUTATIVE RACEMASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 109
VAL A  36
ALA A  61
VAL A  64
GLY A  56
 None
 1.01A 5igjA-2ovlA:
undetectable		 5igjA-2ovlA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A1200
ALA A1587
ALA A1382
VAL A1027
GLY A1248
 None
 1.06A 5igjA-2pffA:
undetectable		 5igjA-2pffA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A1200
ALA A1587
ALA A1382
VAL A1027
GLY A1330
 None
 1.06A 5igjA-2pffA:
undetectable		 5igjA-2pffA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Vibrio cholerae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 ILE A 107
VAL A  93
ALA A   9
ALA A  71
GLY A  12
 None
 1.00A 5igjA-2qz9A:
undetectable		 5igjA-2qz9A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr2 DIHYDROPYRIMIDINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 ASP A  17
TYR A 389
ALA A 382
ALA A 383
GLY A  63
 None
 1.10A 5igjA-2vr2A:
undetectable		 5igjA-2vr2A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ILE A 214
VAL A 157
ALA A 290
VAL A 309
GLY A 316
 None
 1.02A 5igjA-2xf8A:
undetectable		 5igjA-2xf8A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CYTOCHROME C OXIDASE
SUBUNIT 2

(Thermus
thermophilus) 		PF00034
(Cytochrom_C)
PF00115
(COX1)
PF00116
(COX2)
PF00510
(COX3)
PF02790
(COX2_TM) 		5 ILE B 161
ALA A 214
ALA A 215
VAL A 219
GLY A 638
 None
 0.74A 5igjA-2yevB:
undetectable		 5igjA-2yevB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE

(Lactobacillus
delbrueckii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ILE A  84
VAL A  49
ALA A 322
VAL A  71
GLY A 325
 None
 1.09A 5igjA-2yq4A:
undetectable		 5igjA-2yq4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzj GLUCURONAN LYASE A

(Trichoderma
reesei) 		PF14099
(Polysacc_lyase) 		5 ILE A 112
TYR A 221
VAL A 197
ALA A  37
VAL A 224
 None
 1.10A 5igjA-2zzjA:
undetectable		 5igjA-2zzjA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akf PUTATIVE SECRETED
ALPHA
L-ARABINOFURANOSIDAS
E II

(Streptomyces
avermitilis) 		PF04616
(Glyco_hydro_43)
PF05270
(AbfB) 		5 ILE A  83
TYR A  90
VAL A  89
ALA A  77
GLY A 197
 None
None
None
GOL  A 591 ( 4.4A)
NA  A 502 ( 4.7A)
 0.99A 5igjA-3akfA:
undetectable		 5igjA-3akfA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8l FTSZ-LIKE PROTEIN OF
UNKNOWN FUNCTION

(Nostoc
punctiforme) 		PF09585
(Lin0512_fam) 		5 GLU A  65
ALA A  24
ALA A  25
VAL A  29
GLY A  89
 None
 0.80A 5igjA-3c8lA:
undetectable		 5igjA-3c8lA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX

(Escherichia
coli) 		PF03320
(FBPase_glpX) 		5 ILE A  53
ASP A  33
ALA A  17
ALA A  16
VAL A  12
 None
CA  A 337 (-2.7A)
None
None
None
 0.96A 5igjA-3d1rA:
undetectable		 5igjA-3d1rA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN

(Pyrococcus
furiosus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		5 ILE A 102
VAL A 133
GLU A 164
ALA A 143
VAL A 117
 None
 1.05A 5igjA-3dm5A:
undetectable		 5igjA-3dm5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e53 FATTY-ACID-COA
LIGASE FADD28

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		5 ILE A 457
ASP A 222
VAL A 338
ALA A 411
VAL A 405
 None
 1.05A 5igjA-3e53A:
undetectable		 5igjA-3e53A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk3 PROTEIN AF-9 HOMOLOG

(Saccharomyces
cerevisiae) 		PF03366
(YEATS) 		5 ILE A 153
ASP A  54
VAL A  47
ALA A  79
VAL A  62
 None
 1.03A 5igjA-3fk3A:
undetectable		 5igjA-3fk3A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF02738
(Ald_Xan_dh_C2) 		5 ILE B  30
VAL B  38
ALA B  25
ALA B  26
VAL B  97
 None
 1.00A 5igjA-3hrdB:
undetectable		 5igjA-3hrdB:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6d PROTOPORPHYRINOGEN
OXIDASE

(Bacillus
subtilis) 		PF01593
(Amino_oxidase) 		5 VAL A 314
ALA A 344
VAL A 387
GLY A 331
THR A 330
 None
 0.96A 5igjA-3i6dA:
undetectable		 5igjA-3i6dA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juj UDP-GLUCOSE
PYROPHOSPHORYLASE
(GALU)

(Helicobacter
pylori) 		PF00483
(NTP_transferase) 		5 ILE A 230
ALA A  10
VAL A  54
GLY A  13
THR A  14
 None
 1.10A 5igjA-3jujA:
undetectable		 5igjA-3jujA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2z BIRA BIFUNCTIONAL
PROTEIN

(Mycobacterium
tuberculosis) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		5 ILE A  59
VAL A 155
ALA A 104
ALA A 105
VAL A 109
 None
 0.90A 5igjA-3l2zA:
undetectable		 5igjA-3l2zA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES

(Arabidopsis
thaliana) 		PF01048
(PNP_UDP_1) 		5 ASP A 179
ALA A 204
ALA A 205
VAL A 209
GLY A 152
 None
 1.06A 5igjA-3lgsA:
undetectable		 5igjA-3lgsA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhi D7 PROTEIN

(Anopheles
stephensi) 		PF01395
(PBP_GOBP) 		5 ILE A  75
TYR A 117
VAL A 120
ALA A 116
GLY A 108
 None
EAH  A   1 (-4.6A)
None
None
None
 1.10A 5igjA-3nhiA:
undetectable		 5igjA-3nhiA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkg PROTEIN AMBP

(Homo sapiens) 		PF00061
(Lipocalin) 		5 MET A 163
ILE A  30
VAL A  46
GLU A  74
GLY A  23
 None
 1.09A 5igjA-3qkgA:
undetectable		 5igjA-3qkgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhg PUTATIVE
PHOPHOTRIESTERASE

(Proteus
mirabilis) 		PF02126
(PTE) 		5 ILE A  74
ALA A 161
ALA A 121
VAL A 119
GLY A 153
 None
 1.03A 5igjA-3rhgA:
undetectable		 5igjA-3rhgA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t12 GLIDING PROTEIN MGLB

(Thermus
thermophilus) 		PF03259
(Robl_LC7) 		5 VAL B  96
GLU B 101
ALA B  68
ALA B  67
VAL B  63
 None
 1.05A 5igjA-3t12B:
undetectable		 5igjA-3t12B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3toe DNA/RNA-BINDING
PROTEIN ALBA

(Methanothermobacter
thermautotrophicus) 		PF01918
(Alba) 		5 ILE A  61
ASP A  46
VAL A  51
VAL A  21
GLY A  10
 None
 1.10A 5igjA-3toeA:
undetectable		 5igjA-3toeA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti) 		PF00294
(PfkB) 		5 ILE A 211
VAL A   6
ALA A  65
VAL A  68
GLY A  59
 None
None
None
None
ADN  A 353 (-3.2A)
 1.08A 5igjA-3uboA:
undetectable		 5igjA-3uboA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vs8 TYPE III POLYKETIDE
SYNTHASE

(Azotobacter
vinelandii) 		PF02797
(Chal_sti_synt_C) 		5 VAL A 178
ALA A 164
MET A 167
VAL A 168
GLY A 135
 None
 0.98A 5igjA-3vs8A:
undetectable		 5igjA-3vs8A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w25 GLYCOSIDE HYDROLASE
FAMILY 10

(Thermoanaerobacterium
saccharolyticum) 		PF00331
(Glyco_hydro_10) 		5 MET A 201
ILE A 191
VAL A 205
VAL A 245
GLY A 140
 None
 1.08A 5igjA-3w25A:
undetectable		 5igjA-3w25A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A2015
GLU A1990
ALA A1998
MET A2001
GLY A2104
 None
 1.03A 5igjA-3zbfA:
6.8		 5igjA-3zbfA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00348
(polyprenyl_synt) 		5 ILE A   2
VAL A 291
ALA A 217
GLY A 182
THR A 181
 6H6  A1299 ( 4.1A)
None
None
None
None
 1.07A 5igjA-3zouA:
undetectable		 5igjA-3zouA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 ILE A 193
VAL A 463
GLU A 530
MET A 442
VAL A 445
 None
 1.00A 5igjA-4am3A:
undetectable		 5igjA-4am3A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		5 ILE A 706
ALA A 443
ALA A 444
MET A 447
GLY A 427
 None
 1.10A 5igjA-4av6A:
undetectable		 5igjA-4av6A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Thermobispora
bispora) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A  88
VAL A  84
ALA A  62
ALA A  61
VAL A 108
 None
 1.04A 5igjA-4dhgA:
undetectable		 5igjA-4dhgA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e09 PLASMID PARTITIONING
PROTEIN PARF

(Escherichia
coli) 		PF01656
(CbiA) 		5 ILE A 102
VAL A  19
GLU A 195
VAL A  35
GLY A  30
 None
 1.09A 5igjA-4e09A:
undetectable		 5igjA-4e09A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3a SUGAR KINASE PROTEIN

(Rhizobium etli) 		PF00294
(PfkB) 		5 ILE A 209
VAL A   4
ALA A  63
VAL A  66
GLY A  57
 None
None
None
None
ADN  A 500 (-3.7A)
 1.07A 5igjA-4e3aA:
undetectable		 5igjA-4e3aA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gh4 CAPSID PROTEIN VP1
CAPSID PROTEIN VP2

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		5 ILE B 197
VAL B 109
VAL B 123
GLY A   5
THR A   4
 None
 1.04A 5igjA-4gh4B:
undetectable		 5igjA-4gh4B:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxy PLM1

(Streptomyces
sp. HK803) 		PF08659
(KR) 		5 VAL A  57
GLU A  30
ALA A  69
ALA A  70
VAL A  74
 None
 0.95A 5igjA-4hxyA:
undetectable		 5igjA-4hxyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6j F-BOX/LRR-REPEAT
PROTEIN 3

(Homo sapiens) 		PF12937
(F-box-like) 		5 ILE B 392
VAL B 380
GLU B 349
ALA B 355
GLY B 328
 None
 0.89A 5igjA-4i6jB:
undetectable		 5igjA-4i6jB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv6 ACYL-COA
DEHYDROGENASE FADE3

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ILE A 359
ASP A 332
ALA A 256
VAL A 252
GLY A 288
 None
 1.06A 5igjA-4iv6A:
undetectable		 5igjA-4iv6A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqk NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Salmonella
enterica) 		PF02277
(DBI_PRT) 		5 ILE A 137
GLU A 149
ALA A 274
ALA A 273
GLY A 248
 None
 0.99A 5igjA-4kqkA:
undetectable		 5igjA-4kqkA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lx4 ENDOGLUCANASE(ENDO-1
,4-BETA-GLUCANASE)PR
OTEIN

(Pseudomonas
stutzeri) 		PF00150
(Cellulase) 		5 ILE A 202
ALA A 155
ALA A 156
VAL A 160
GLY A 102
 None
 0.82A 5igjA-4lx4A:
undetectable		 5igjA-4lx4A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mch URIDINE
PHOSPHORYLASE

(Aliivibrio
fischeri) 		PF01048
(PNP_UDP_1) 		5 ILE A  60
VAL A  85
GLU A 135
ALA A 128
ALA A 197
 None
 1.08A 5igjA-4mchA:
undetectable		 5igjA-4mchA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE

(Lactobacillus
casei) 		PF01408
(GFO_IDH_MocA) 		5 ILE A  67
ALA A  40
ALA A  41
VAL A  45
GLY A  11
 None
NAI  A 401 ( 4.5A)
None
None
NAI  A 401 (-3.3A)
 1.07A 5igjA-4mioA:
undetectable		 5igjA-4mioA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2w E3 UBIQUITIN-PROTEIN
LIGASE HERC1

(Homo sapiens) 		PF00415
(RCC1) 		5 VAL A4296
ALA A4192
ALA A4245
VAL A4252
GLY A4142
 None
 1.09A 5igjA-4o2wA:
undetectable		 5igjA-4o2wA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o3s DNA POLYMERASE ETA

(Homo sapiens) 		PF00817
(IMS)
PF11799
(IMS_C) 		5 MET A 200
ILE A 196
ALA A 112
ALA A 117
VAL A  12
 None
 0.94A 5igjA-4o3sA:
undetectable		 5igjA-4o3sA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4olo BMC DOMAIN PROTEIN

(Clostridiales
bacterium
1_7_47FAA) 		PF00936
(BMC) 		5 ILE A  63
GLU A  84
ALA A  55
ALA A  52
GLY A  57
 None
 1.09A 5igjA-4oloA:
undetectable		 5igjA-4oloA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB

(Escherichia
coli) 		PF07244
(POTRA)
PF13360
(PQQ_2) 		5 ILE A1390
ALA A1075
ALA A1074
VAL A1072
GLY A1053
 None
 1.10A 5igjA-4pk1A:
undetectable		 5igjA-4pk1A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvg SIBL

(Streptosporangium
sibiricum) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 TYR A 134
ALA A 139
ALA A 138
GLY A 128
THR A 129
 None
 1.05A 5igjA-4qvgA:
undetectable		 5igjA-4qvgA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r27 GLYCOSIDE HYDROLASE

(Microbacterium
sp. Gsoil167) 		PF00232
(Glyco_hydro_1) 		5 ILE A 389
GLU A 141
ALA A 202
ALA A 201
GLY A 193
 None
 1.01A 5igjA-4r27A:
undetectable		 5igjA-4r27A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru4 TAIL SPIKE PROTEIN
GP49

(Pseudomonas
virus LKA1) 		PF13229
(Beta_helix) 		5 TYR A 318
VAL A 470
GLU A 336
ALA A 364
GLY A 360
 None
 1.05A 5igjA-4ru4A:
undetectable		 5igjA-4ru4A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y96 TRIOSEPHOSPHATE
ISOMERASE

(Gemmata
obscuriglobus) 		PF00121
(TIM) 		5 ILE A 250
ALA A 190
ALA A 187
VAL A 232
GLY A 132
 None
 0.97A 5igjA-4y96A:
undetectable		 5igjA-4y96A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxs VIRION EGRESS
PROTEIN UL31

(Human
alphaherpesvirus
1) 		PF02718
(Herpes_UL31) 		5 MET B 234
ILE B 231
VAL B 188
VAL B 256
THR B 251
 None
NA  B 402 (-3.8A)
None
None
None
 0.90A 5igjA-4zxsB:
0.8		 5igjA-4zxsB:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5l D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE

(Thermosynechococcus
elongatus) 		PF03320
(FBPase_glpX) 		5 ILE A  53
ASP A  33
ALA A  17
ALA A  16
VAL A  12
 None
MG  A1341 (-3.3A)
None
None
None
 1.08A 5igjA-5a5lA:
undetectable		 5igjA-5a5lA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8d CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF04616
(Glyco_hydro_43) 		5 MET A 310
ILE A 318
ALA A  45
ALA A 274
GLY A 168
 None
None
GOL  A1340 (-3.6A)
GOL  A1340 (-3.0A)
GOL  A1340 (-3.3A)
 1.09A 5igjA-5a8dA:
undetectable		 5igjA-5a8dA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5coa IRIDOID SYNTHASE

(Catharanthus
roseus) 		no annotation 5 ILE A 145
GLU A 256
ALA A 267
VAL A 271
GLY A 363
 None
 1.08A 5igjA-5coaA:
undetectable		 5igjA-5coaA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCA-B

(synthetic
construct) 		PF00291
(PALP) 		5 ASP B 326
ALA B 266
ALA B 265
GLY B 262
THR B 261
 None
 1.04A 5igjA-5ey5B:
undetectable		 5igjA-5ey5B:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby SEPARASE

(Chaetomium
thermophilum) 		PF03568
(Peptidase_C50) 		5 VAL A2189
ALA A2205
ALA A2206
VAL A2139
THR A2146
 None
 1.02A 5igjA-5fbyA:
undetectable		 5igjA-5fbyA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flw EXO-BETA-1,3-GALACTA
NASE

(Bifidobacterium
bifidum) 		PF04616
(Glyco_hydro_43) 		5 ILE A 172
VAL A 113
GLU A  82
VAL A  96
GLY A  24
 None
 0.91A 5igjA-5flwA:
undetectable		 5igjA-5flwA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ica PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF04003
(Utp12)
PF08625
(Utp13) 		5 ILE B 806
GLU A 916
ALA A 922
ALA A 923
VAL A 927
 None
 1.09A 5igjA-5icaB:
undetectable		 5igjA-5icaB:
19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E

(Escherichia
coli) 		PF01636
(APH) 		12 MET A 103
ILE A 105
ASP A 200
TYR A 202
VAL A 203
GLU A 222
ALA A 233
ALA A 234
MET A 237
VAL A 238
GLY A 273
THR A 276
 ERY  A 402 (-2.2A)
ERY  A 402 ( 4.4A)
ERY  A 402 (-2.4A)
ERY  A 402 (-2.7A)
None
ERY  A 402 ( 3.9A)
ERY  A 402 ( 3.9A)
ERY  A 402 ( 3.2A)
ERY  A 402 ( 3.0A)
ERY  A 402 ( 4.7A)
ERY  A 402 ( 3.6A)
ERY  A 402 ( 3.8A)
 0.40A 5igjA-5igpA:
48.1		 5igjA-5igpA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihs ENDOGLUCANASE,
GLYCOSIDE HYDROLASE
FAMILY 5 PROTEIN

(Cytophaga
hutchinsonii) 		PF00150
(Cellulase) 		5 VAL A 156
GLU A 101
ALA A 134
ALA A 135
VAL A 177
 None
 1.07A 5igjA-5ihsA:
undetectable		 5igjA-5ihsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 ILE A 198
GLU A 100
ALA A 103
VAL A 112
GLY A 119
 None
EDO  A1007 ( 4.9A)
None
None
None
 1.05A 5igjA-5jouA:
1.1		 5igjA-5jouA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN7

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF10602
(RPN7) 		5 ILE R 271
GLU R 332
ALA R 227
ALA R 228
VAL R 232
 None
 0.98A 5igjA-5mpdR:
undetectable		 5igjA-5mpdR:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nth PUTATIVE
AMINOPEPTIDASE

(Leishmania
major) 		PF00883
(Peptidase_M17) 		5 ASP A 119
VAL A 152
ALA A 124
VAL A 142
GLY A  82
 None
 0.93A 5igjA-5nthA:
undetectable		 5igjA-5nthA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G

(Methanothermococcus
thermolithotrophicus) 		PF01058
(Oxidored_q6) 		5 ILE E   4
VAL E  79
ALA E  87
ALA E  81
GLY E 148
 None
None
ACT  E 301 (-4.3A)
ACT  E 301 ( 4.5A)
None
 0.89A 5igjA-5odrE:
undetectable		 5igjA-5odrE:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oji DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4

(Caenorhabditis
elegans) 		no annotation 5 ILE A  39
VAL A  93
GLU A 138
ALA A 238
VAL A 234
 None
 0.91A 5igjA-5ojiA:
undetectable		 5igjA-5ojiA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olc GALACTONATE
DEHYDRATASE

(Zobellia
galactanivorans) 		no annotation 5 ILE A 265
ALA A 306
ALA A 307
VAL A 311
GLY A 275
 None
 0.74A 5igjA-5olcA:
undetectable		 5igjA-5olcA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tch TRYPTOPHAN SYNTHASE
BETA CHAIN

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		5 ASP B 343
ALA B 283
ALA B 282
GLY B 279
THR B 278
 None
 1.10A 5igjA-5tchB:
undetectable		 5igjA-5tchB:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj3 ALKALINE PHOSPHATASE
PAFA

(Elizabethkingia
meningoseptica) 		PF01663
(Phosphodiest) 		5 ILE A  86
VAL A 523
GLU A 542
VAL A  32
GLY A  64
 None
 0.99A 5igjA-5tj3A:
undetectable		 5igjA-5tj3A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE

(Hypericum
androsaemum) 		no annotation 5 ILE A 313
VAL A 383
MET A 287
VAL A 286
GLY A 372
 None
 1.08A 5igjA-5ucoA:
undetectable		 5igjA-5ucoA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE

(Streptomyces
peucetius) 		no annotation 6 ASP A 302
VAL A 164
ALA A 166
MET A 149
GLY A 146
THR A 145
 None
 1.33A 5igjA-5wgcA:
undetectable		 5igjA-5wgcA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6amz 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E

(Acinetobacter
baumannii) 		PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2) 		5 ILE A 178
VAL A 227
ALA A 249
ALA A 250
VAL A 233
 None
 1.08A 5igjA-6amzA:
undetectable		 5igjA-6amzA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT C
ALTERNATIVE COMPLEX
III SUBUNIT D

(Flavobacterium
johnsoniae) 		no annotation 5 VAL C 177
ALA D 111
ALA D 112
MET D 115
VAL D 116
 None
 0.96A 5igjA-6btmC:
undetectable		 5igjA-6btmC:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ch3 FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Salmonella
enterica) 		no annotation 6 MET A 365
ILE A 420
VAL A 367
MET A 374
VAL A 375
GLY A 435
 None
 1.43A 5igjA-6ch3A:
undetectable		 5igjA-6ch3A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fht BACTERIOPHYTOCHROME,
ADENYLATE CYCLASE

(Deinococcus
radiodurans;
Synechocystis
sp. PCC 6803) 		no annotation 5 ILE A 675
GLU A 648
ALA A 609
VAL A 613
GLY A 600
 None
 1.10A 5igjA-6fhtA:
undetectable		 5igjA-6fhtA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2v METHYLAMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 PRO A 582
HIS A 618
LEU A 409
PHE A 293
 None
 1.41A 5igjA-1a2vA:
0.1		 5igjA-1a2vA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)

(Rattus
norvegicus) 		PF00171
(Aldedh) 		4 PRO A 138
LEU A  70
TYR A 412
PHE A 401
 None
 1.43A 5igjA-1ad3A:
0.0		 5igjA-1ad3A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT
[NIFE] HYDROGENASE
SMALL SUBUNIT

(Desulfovibrio
desulfuricans) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 PRO A 151
HIS B 112
LEU A  35
TYR A  28
 FSX  A 269 (-3.8A)
None
None
None
 1.37A 5igjA-1e3dA:
undetectable		 5igjA-1e3dA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gc7 RADIXIN

(Mus musculus) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 PRO A 154
LEU A 234
TYR A 201
PHE A  85
 PRO  A 154 ( 1.1A)
LEU  A 234 ( 0.6A)
TYR  A 201 ( 1.3A)
PHE  A  85 ( 1.3A)
 1.26A 5igjA-1gc7A:
undetectable		 5igjA-1gc7A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjv CHITINASE-3 LIKE
PROTEIN 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 PRO A 142
LEU A 254
TYR A 243
PHE A 234
 None
 1.24A 5igjA-1hjvA:
undetectable		 5igjA-1hjvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k26 NUDIX HOMOLOG

(Pyrobaculum
aerophilum) 		PF00293
(NUDIX) 		4 PRO A  38
HIS A  31
TYR A  27
PHE A 122
 None
IR3  A 206 (-4.0A)
None
GOL  A 209 ( 4.8A)
 1.46A 5igjA-1k26A:
0.0		 5igjA-1k26A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfw PEPV

(Lactobacillus
delbrueckii) 		PF01546
(Peptidase_M20) 		4 PRO A 220
HIS A 308
LEU A 207
TYR A 239
 None
 1.20A 5igjA-1lfwA:
0.8		 5igjA-1lfwA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqa TAS PROTEIN

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		4 HIS A   4
LEU A 307
TYR A 208
PHE A 215
 None
 1.27A 5igjA-1lqaA:
0.0		 5igjA-1lqaA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwh 4-ALPHA-GLUCANOTRANS
FERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09178
(DUF1945) 		4 PRO A 308
HIS A 375
LEU A 404
PHE A 289
 None
 1.48A 5igjA-1lwhA:
undetectable		 5igjA-1lwhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1l SUPPRESSOR OF FUSED

(Homo sapiens) 		PF05076
(SUFU) 		4 PRO A 134
HIS A  89
LEU A 144
PHE A  93
 None
 1.35A 5igjA-1m1lA:
undetectable		 5igjA-1m1lA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mco IGG1 MCG INTACT
ANTIBODY (HEAVY
CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PRO H 229
HIS H 420
LEU H 391
TYR H 358
 GAL  H 435 (-4.8A)
None
None
None
 1.06A 5igjA-1mcoH:
undetectable		 5igjA-1mcoH:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlu SEDOLISIN

(Pseudomonas sp.) 		no annotation 4 PRO A 260
LEU A 361
TYR A  17
PHE A  13
 None
 1.43A 5igjA-1nluA:
undetectable		 5igjA-1nluA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		4 PRO A 520
HIS A 515
LEU A  28
TYR A  36
 None
 1.47A 5igjA-1obhA:
undetectable		 5igjA-1obhA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sma MALTOGENIC AMYLASE

(Thermus sp.
IM6501) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 PRO A 453
LEU A 486
TYR A 457
PHE A 145
 None
 1.48A 5igjA-1smaA:
3.2		 5igjA-1smaA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus) 		PF00135
(COesterase) 		4 PRO A  90
HIS A 451
TYR A 146
PHE A 485
 None
 1.46A 5igjA-1thgA:
undetectable		 5igjA-1thgA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 PRO B 339
HIS B 170
LEU B 181
PHE A 408
 None
 1.45A 5igjA-1tqyB:
undetectable		 5igjA-1tqyB:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf8 SECRETORY PROTEIN

(Mus musculus) 		PF00704
(Glyco_hydro_18) 		4 PRO A 269
HIS A 248
LEU A 289
TYR A 283
 None
 1.45A 5igjA-1vf8A:
undetectable		 5igjA-1vf8A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3w PEPTIDE:N-GLYCANASE

(Saccharomyces
cerevisiae) 		PF03835
(Rad4) 		4 PRO A 244
LEU A 202
TYR A 211
PHE A 261
 None
 1.46A 5igjA-1x3wA:
undetectable		 5igjA-1x3wA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT

(Homo sapiens) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		4 PRO A  54
HIS A  71
LEU A 128
PHE A 241
 None
ZN  A 482 (-3.5A)
None
None
 1.49A 5igjA-2i7tA:
undetectable		 5igjA-2i7tA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1

(Arabidopsis
thaliana) 		PF00724
(Oxidored_FMN) 		4 PRO A  15
LEU A  60
TYR A 325
PHE A 306
 None
 1.37A 5igjA-2q3rA:
undetectable		 5igjA-2q3rA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v79 DNA REPLICATION
PROTEIN DNAD

(Bacillus
subtilis) 		no annotation 4 PRO A 101
LEU A  57
TYR A  50
PHE A  94
 None
 1.31A 5igjA-2v79A:
undetectable		 5igjA-2v79A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vge RELA-ASSOCIATED
INHIBITOR

(Homo sapiens) 		PF00023
(Ank)
PF14604
(SH3_9) 		4 PRO A 696
HIS A 715
LEU A 640
TYR A 673
 None
 1.46A 5igjA-2vgeA:
undetectable		 5igjA-2vgeA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsm HEMAGGLUTININ-NEURAM
INIDASE

(Nipah
henipavirus) 		PF00423
(HN) 		4 PRO A 535
LEU A 222
TYR A 454
PHE A 466
 None
None
IPA  A1604 (-4.5A)
None
 1.39A 5igjA-2vsmA:
1.8		 5igjA-2vsmA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wuy POLYHEDRIN

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00738
(Polyhedrin) 		4 PRO A 149
HIS A 139
LEU A  71
TYR A  95
 None
 1.48A 5igjA-2wuyA:
undetectable		 5igjA-2wuyA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzr UNSATURATED
GLUCURONYL HYDROLASE

(Streptococcus
agalactiae) 		PF07470
(Glyco_hydro_88) 		4 PRO A 257
LEU A 340
TYR A 381
PHE A  73
 None
 1.22A 5igjA-2zzrA:
undetectable		 5igjA-2zzrA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzr UNSATURATED
GLUCURONYL HYDROLASE

(Streptococcus
agalactiae) 		PF07470
(Glyco_hydro_88) 		4 PRO A 257
LEU A 343
TYR A 381
PHE A  73
 None
 1.26A 5igjA-2zzrA:
undetectable		 5igjA-2zzrA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Rattus
norvegicus) 		PF06325
(PrmA) 		4 PRO A 374
LEU A 467
TYR A 449
PHE A 265
 None
BEN  A1001 (-4.5A)
BEN  A6001 ( 4.1A)
BEN  A4001 ( 4.0A)
 1.49A 5igjA-3b3jA:
1.0		 5igjA-3b3jA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb6 UNCHARACTERIZED
PROTEIN YEAR

(Escherichia
coli) 		PF09313
(DUF1971) 		4 PRO A  63
HIS A  30
LEU A   2
PHE A  94
 None
ZN  A 128 (-4.1A)
None
None
 1.41A 5igjA-3bb6A:
undetectable		 5igjA-3bb6A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfh MANDELATE RACEMASE

(Vibrionales
bacterium
SWAT-3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PRO A 237
HIS A 209
LEU A 188
PHE A 231
 None
 1.42A 5igjA-3dfhA:
undetectable		 5igjA-3dfhA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 HIS A 352
LEU A 568
TYR A 579
PHE A 578
 None
TDM  A 700 (-3.8A)
None
None
 1.43A 5igjA-3e9yA:
undetectable		 5igjA-3e9yA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 PRO A 299
HIS A 497
LEU A 409
PHE A 330
 None
HBX  A 530 ( 3.9A)
None
HBX  A 530 (-4.0A)
 1.46A 5igjA-3gdnA:
undetectable		 5igjA-3gdnA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjw 50S RIBOSOMAL
PROTEIN L7AE
PSEUDOURIDINE
SYNTHASE CBF5

(Pyrococcus
furiosus) 		PF01248
(Ribosomal_L7Ae)
PF01472
(PUA)
PF01509
(TruB_N)
PF08068
(DKCLD)
PF16198
(TruB_C_2) 		4 PRO C  60
LEU A  54
TYR A 226
PHE A 229
 None
 1.31A 5igjA-3hjwC:
undetectable		 5igjA-3hjwC:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 PRO B1016
HIS B 841
LEU A 411
TYR A 377
 None
 1.12A 5igjA-3hkzB:
undetectable		 5igjA-3hkzB:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ide CAPSID PROTEIN VP2

(Infectious
pancreatic
necrosis virus) 		PF01766
(Birna_VP2) 		4 PRO A  57
LEU A 364
TYR A  68
PHE A  79
 None
 1.40A 5igjA-3ideA:
undetectable		 5igjA-3ideA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN

(Rhodobacter
sphaeroides) 		PF02126
(PTE) 		4 PRO A 104
HIS A 301
TYR A 268
PHE A 266
 None
 1.48A 5igjA-3k2gA:
undetectable		 5igjA-3k2gA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzq PUTATIVE
UNCHARACTERIZED
PROTEIN VP2116

(Vibrio
parahaemolyticus) 		PF13743
(Thioredoxin_5) 		4 PRO A 122
HIS A 113
LEU A 137
TYR A 104
 None
None
None
PG6  A 209 (-4.1A)
 1.47A 5igjA-3kzqA:
undetectable		 5igjA-3kzqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		4 PRO A   3
HIS A 282
LEU A  50
PHE A 272
 None
 1.42A 5igjA-3lpdA:
undetectable		 5igjA-3lpdA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		4 PRO A 299
HIS A 236
LEU A 115
TYR A  67
 None
None
None
AOO  A 457 (-4.7A)
 1.46A 5igjA-3lscA:
undetectable		 5igjA-3lscA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ovg AMIDOHYDROLASE

(Mycoplasma
synoviae) 		PF02126
(PTE) 		4 HIS A 214
LEU A 169
TYR A 105
PHE A 104
 ZN  A 363 (-3.5A)
None
None
None
 1.47A 5igjA-3ovgA:
undetectable		 5igjA-3ovgA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psg PEPSINOGEN

(Sus scrofa) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		4 PRO A   5
HIS A  53
LEU A  38
PHE A  15
 None
 1.42A 5igjA-3psgA:
undetectable		 5igjA-3psgA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdq 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Clostridium
aminobutyricum) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 PRO A 184
HIS A  31
TYR A  66
PHE A  77
 None
 1.46A 5igjA-3qdqA:
undetectable		 5igjA-3qdqA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PRO A 229
LEU A 141
TYR A  72
PHE A  71
 None
 1.37A 5igjA-3r44A:
undetectable		 5igjA-3r44A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 PRO A 300
HIS A 498
LEU A 410
PHE A 331
 None
FAD  A 773 (-4.4A)
None
None
 1.43A 5igjA-3redA:
undetectable		 5igjA-3redA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0j TYPE III EFFECTOR
HOPU1

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 4 PRO B 239
HIS B 141
TYR B  78
PHE B  66
 None
 1.47A 5igjA-3u0jB:
undetectable		 5igjA-3u0jB:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsc PROTEIN CYSO

(Aeropyrum
pernix) 		PF00291
(PALP) 		4 PRO A  96
HIS A 234
LEU A  29
TYR A  51
 None
 1.48A 5igjA-3vscA:
undetectable		 5igjA-3vscA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae) 		PF00291
(PALP) 		4 PRO A 291
HIS A 217
LEU A 239
PHE A 226
 PLP  A 401 (-4.1A)
None
None
None
 1.20A 5igjA-3x43A:
undetectable		 5igjA-3x43A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		4 HIS A1919
LEU A2077
TYR A2064
PHE A2061
 None
 1.11A 5igjA-4asiA:
undetectable		 5igjA-4asiA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bla MALTOSE-BINDING
PERIPLASMIC PROTEIN,
SUPPRESSOR OF FUSED
HOMOLOG

(Escherichia
coli;
Homo sapiens) 		PF05076
(SUFU)
PF12470
(SUFU_C)
PF13416
(SBP_bac_8) 		4 PRO A 474
HIS A 429
LEU A 484
PHE A 433
 None
 1.41A 5igjA-4blaA:
undetectable		 5igjA-4blaA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bz7 HISTONE DEACETYLASE
8

(Schistosoma
mansoni) 		PF00850
(Hist_deacetyl) 		4 HIS A 142
LEU A  97
TYR A 110
PHE A  21
 B3N  A 700 (-3.7A)
None
None
None
 1.46A 5igjA-4bz7A:
undetectable		 5igjA-4bz7A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 PRO A 315
HIS A 184
LEU A 249
PHE A 269
 None
ZN  A1003 (-3.6A)
None
None
 1.38A 5igjA-4eo4A:
undetectable		 5igjA-4eo4A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezi UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 PRO A 222
HIS A 327
TYR A 157
PHE A 251
 None
None
None
PEG  A 501 (-4.6A)
 1.37A 5igjA-4eziA:
undetectable		 5igjA-4eziA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 PRO A 554
LEU A 421
TYR A 415
PHE A 379
 None
 1.45A 5igjA-4f99A:
8.3		 5igjA-4f99A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM

(Sulfolobus
solfataricus) 		no annotation 4 PRO B 104
LEU B  74
TYR B  30
PHE B  21
 None
 1.28A 5igjA-4fdgB:
undetectable		 5igjA-4fdgB:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvl MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
thermoresistibile) 		PF00082
(Peptidase_S8) 		4 PRO A 289
LEU A 278
TYR A 339
PHE A 335
 None
 1.39A 5igjA-4hvlA:
undetectable		 5igjA-4hvlA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 PRO A 619
HIS A 497
LEU A 552
PHE A 572
 None
ZN  A 801 ( 3.3A)
None
None
 1.32A 5igjA-4hwtA:
undetectable		 5igjA-4hwtA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifs FACT COMPLEX SUBUNIT
SSRP1

(Homo sapiens) 		PF08512
(Rtt106) 		4 PRO A 366
LEU A 205
TYR A 232
PHE A 230
 None
 1.50A 5igjA-4ifsA:
undetectable		 5igjA-4ifsA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgb PUTATIVE EXPORTED
PROTEIN

(Burkholderia
pseudomallei) 		PF13460
(NAD_binding_10) 		4 PRO A  71
LEU A 172
TYR A 209
PHE A 165
 SO4  A 302 (-3.1A)
None
None
None
 1.37A 5igjA-4jgbA:
undetectable		 5igjA-4jgbA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 PRO A 205
LEU A 108
TYR A 252
PHE A 141
 None
None
None
GOL  A 301 (-4.0A)
 1.34A 5igjA-4kcdA:
undetectable		 5igjA-4kcdA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		4 PRO A 289
LEU A 278
TYR A 339
PHE A 335
 None
 1.47A 5igjA-4kpgA:
undetectable		 5igjA-4kpgA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4
R-SPONDIN-1

(Homo sapiens;
Xenopus
tropicalis) 		PF13516
(LRR_6)
PF13855
(LRR_8)
PF15913
(Furin-like_2) 		4 PRO B  89
HIS A 210
LEU A 240
TYR A 283
 None
 1.39A 5igjA-4li2B:
undetectable		 5igjA-4li2B:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		4 PRO A 289
LEU A 278
TYR A 339
PHE A 335
 None
 1.45A 5igjA-4m1zA:
undetectable		 5igjA-4m1zA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q65 DIPEPTIDE PERMEASE D

(Escherichia
coli) 		PF00854
(PTR2) 		4 PRO A 155
LEU A 107
TYR A 114
PHE A 117
 None
 1.20A 5igjA-4q65A:
undetectable		 5igjA-4q65A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
R-SPONDIN-2

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8)
PF15913
(Furin-like_2) 		4 PRO B  88
HIS A 216
LEU A 246
TYR A 289
 None
 1.43A 5igjA-4ufsB:
undetectable		 5igjA-4ufsB:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE

(Agrobacterium
tumefaciens) 		PF00701
(DHDPS) 		4 PRO A 111
LEU A  15
TYR A 202
PHE A 198
 None
 1.37A 5igjA-4ur8A:
undetectable		 5igjA-4ur8A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v20 CELLOBIOHYDROLASE

(Aspergillus
fumigatus) 		PF00840
(Glyco_hydro_7) 		4 PRO A 177
HIS A 206
LEU A  73
TYR A  51
 None
None
PCA  A   1 ( 4.5A)
None
 1.47A 5igjA-4v20A:
undetectable		 5igjA-4v20A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dld UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Burkholderia
vietnamiensis) 		PF02350
(Epimerase_2) 		4 HIS A 247
LEU A  48
TYR A 274
PHE A 277
 UD1  A 502 (-4.0A)
None
UDP  A 501 (-4.4A)
UDP  A 501 (-3.6A)
 1.15A 5igjA-5dldA:
undetectable		 5igjA-5dldA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo6 COPROPORPHYRINOGEN
OXIDASE

(Acinetobacter
baumannii) 		PF01218
(Coprogen_oxidas) 		4 PRO A 278
HIS A 115
LEU A 303
TYR A 256
 None
ACT  A 400 (-3.1A)
None
None
 1.36A 5igjA-5eo6A:
undetectable		 5igjA-5eo6A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5feb SODIUM CHANNEL
SUBUNIT BETA-2

(Homo sapiens) 		PF07686
(V-set) 		4 PRO A  35
HIS A 139
LEU A  81
TYR A  69
 None
 1.12A 5igjA-5febA:
undetectable		 5igjA-5febA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 PRO A 725
LEU A 641
TYR A 670
PHE A 674
 None
 1.41A 5igjA-5gz4A:
0.3		 5igjA-5gz4A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE

(Medicago
truncatula) 		PF00795
(CN_hydrolase) 		4 HIS A 206
LEU A  45
TYR A 119
PHE A 143
 None
 1.31A 5igjA-5h8kA:
undetectable		 5igjA-5h8kA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hax NUCLEOPORIN NUP170

(Chaetomium
thermophilum) 		PF08801
(Nucleoporin_N) 		4 PRO A 556
LEU A 678
TYR A 605
PHE A 601
 None
 1.32A 5igjA-5haxA:
3.2		 5igjA-5haxA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hss LINALOOL
DEHYDRATASE/ISOMERAS
E

(Castellaniella
defragrans) 		no annotation 4 PRO A 364
HIS A 194
LEU A 131
TYR A 145
 None
 1.41A 5igjA-5hssA:
undetectable		 5igjA-5hssA:
22.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E

(Escherichia
coli) 		PF01636
(APH) 		5 PRO A 112
HIS A 205
LEU A 270
TYR A 277
PHE A 280
 ERY  A 402 ( 4.1A)
GDP  A 401 (-4.4A)
None
ERY  A 402 ( 4.5A)
ERY  A 402 ( 3.6A)
 0.18A 5igjA-5igpA:
48.1		 5igjA-5igpA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		4 PRO A 838
LEU A 860
TYR A 811
PHE A 628
 None
 1.43A 5igjA-5kdxA:
undetectable		 5igjA-5kdxA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C1,
MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2

(Bos taurus) 		PF00329
(Complex1_30kDa)
PF00346
(Complex1_49kDa) 		4 PRO d  52
HIS c   9
LEU c  21
TYR d  64
 None
 1.28A 5igjA-5lc5d:
undetectable		 5igjA-5lc5d:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 PRO X 124
HIS X 111
TYR X 310
PHE X 312
 None
DQP  X 402 ( 4.1A)
None
DQP  X 402 (-4.9A)
 1.38A 5igjA-5liyX:
undetectable		 5igjA-5liyX:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 PRO A  77
HIS A 434
TYR A 369
PHE A 362
 None
 1.17A 5igjA-5m8tA:
undetectable		 5igjA-5m8tA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhf MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Mus musculus) 		no annotation 4 PRO A 249
HIS A 159
LEU A 117
PHE A 155
 None
 1.28A 5igjA-5mhfA:
1.0		 5igjA-5mhfA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thm ESTERASE-6

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 PRO A 220
HIS A 445
LEU A 327
TYR A 273
 None
7BZ  A 601 (-3.8A)
None
None
 1.10A 5igjA-5thmA:
undetectable		 5igjA-5thmA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uh0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F

(Yersinia pestis) 		PF00497
(SBP_bac_3) 		4 PRO A  86
LEU A 209
TYR A 264
PHE A  66
 None
 1.30A 5igjA-5uh0A:
undetectable		 5igjA-5uh0A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujz SCFV

(Homo sapiens) 		PF07686
(V-set) 		4 PRO G  45
HIS G 160
LEU G  34
TYR G 236
 None
 1.40A 5igjA-5ujzG:
undetectable		 5igjA-5ujzG:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ums FACT COMPLEX SUBUNIT
SSRP1

(Homo sapiens) 		no annotation 4 PRO A 366
LEU A 205
TYR A 232
PHE A 230
 None
 1.48A 5igjA-5umsA:
undetectable		 5igjA-5umsA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkq NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L

(Drosophila
melanogaster) 		PF00023
(Ank)
PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4) 		4 PRO A1080
HIS A1056
LEU A1036
TYR A1011
 None
 1.49A 5igjA-5vkqA:
undetectable		 5igjA-5vkqA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3v APOBEC3H

(Macaca
nemestrina) 		no annotation 4 PRO B  36
LEU B  47
TYR B  79
PHE B 107
 None
 1.13A 5igjA-5w3vB:
undetectable		 5igjA-5w3vB:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN

(Pyrococcus
horikoshii) 		no annotation 4 PRO A 281
LEU A 211
TYR A 324
PHE A 319
 None
 1.30A 5igjA-5x09A:
undetectable		 5igjA-5x09A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xev XAA-PRO
DIPEPTIDASE,PEPTIDAS
E-RELATED PROTEIN

(Deinococcus
radiodurans) 		no annotation 4 PRO A  83
LEU A  36
TYR A  23
PHE A  25
 None
None
None
CL  A 505 ( 4.8A)
 1.48A 5igjA-5xevA:
undetectable		 5igjA-5xevA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4u -

(-) 		no annotation 4 PRO A 171
LEU A 248
TYR A 221
PHE A 226
 None
 1.17A 5igjA-5y4uA:
undetectable		 5igjA-5y4uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy0 CYTOSOLIC
NIFE-HYDROGENASE,
ALPHA SUBUNIT

(Thermococcus
kodakarensis) 		no annotation 4 PRO A 377
HIS A 111
LEU A 276
PHE A 304
 None
 1.40A 5igjA-5yy0A:
undetectable		 5igjA-5yy0A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bms PALMITOYLTRANSFERASE

(Danio rerio) 		no annotation 4 HIS A 142
LEU A 137
TYR A 155
PHE A 158
 ZN  A1002 ( 3.1A)
None
None
PLM  A1006 (-4.7A)
 1.42A 5igjA-6bmsA:
2.0		 5igjA-6bmsA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6u -

(-) 		no annotation 4 PRO N 100
LEU N  26
TYR N  68
PHE N  65
 None
 1.37A 5igjA-6c6uN:
undetectable		 5igjA-6c6uN:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0y NUCLEAR CAP-BINDING
PROTEIN SUBUNIT 2

(Homo sapiens) 		no annotation 4 HIS A  24
LEU A  36
TYR A  43
PHE A  83
 None
None
GTA  A 201 (-3.4A)
GTA  A 201 (-3.7A)
 1.40A 5igjA-6d0yA:
undetectable		 5igjA-6d0yA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6df3 -

(-) 		no annotation 4 HIS C 167
LEU C 151
TYR C 116
PHE C 115
 None
 1.22A 5igjA-6df3C:
undetectable		 5igjA-6df3C:
undetectable