SIMILAR PATTERNS OF AMINO ACIDS FOR 5IGI_A_ZITA402_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ae7 PHOSPHOLIPASE A2

(Notechis
scutatus) 		PF00068
(Phospholip_A2_1) 		4 HIS A  48
GLU A 101
LEU A  92
TYR A  75
 None
 1.09A 5igiA-1ae7A:
undetectable		 5igiA-1ae7A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		4 PRO A 396
GLU A 568
LEU A 577
TYR A 485
 None
 0.87A 5igiA-1d8cA:
undetectable		 5igiA-1d8cA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9z EXCINUCLEASE UVRABC
COMPONENT UVRB

([Bacillus]
caldotenax) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		4 HIS A 248
GLU A 208
ALA A 129
TYR A  88
 None
 0.96A 5igiA-1d9zA:
undetectable		 5igiA-1d9zA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0c SULFURTRANSFERASE

(Azotobacter
vinelandii) 		PF00581
(Rhodanese) 		4 PRO A   8
GLU A  90
ALA A 198
TYR A 240
 None
 1.08A 5igiA-1e0cA:
undetectable		 5igiA-1e0cA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g3n V-CYCLIN

(Human
gammaherpesvirus
8) 		PF00134
(Cyclin_N)
PF09080
(K-cyclin_vir_C) 		4 PRO C 187
GLU C  91
ALA C  99
LEU C 138
 None
 1.02A 5igiA-1g3nC:
undetectable		 5igiA-1g3nC:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gdh D-GLYCERATE
DEHYDROGENASE

(Hyphomicrobium
methylovorum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 PRO A 230
ALA A 163
LEU A 162
TYR A 153
 None
 1.08A 5igiA-1gdhA:
undetectable		 5igiA-1gdhA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gt9 KUMAMOLYSIN

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		4 PRO 1  54
ALA 1 281
LEU 1 159
TYR 1  98
 None
 1.06A 5igiA-1gt91:
undetectable		 5igiA-1gt91:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		4 PRO A 169
HIS A 124
GLU A  51
ALA A 150
 None
 1.06A 5igiA-1h4lA:
8.1		 5igiA-1h4lA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 PRO A 455
GLU A 542
ALA A 464
LEU A 390
 None
 1.09A 5igiA-1hp1A:
0.0		 5igiA-1hp1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iir GLYCOSYLTRANSFERASE
GTFB

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		4 PRO A 251
ALA A 362
LEU A 363
TYR A 242
 None
 1.09A 5igiA-1iirA:
undetectable		 5igiA-1iirA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		4 HIS A 464
GLU A 474
LEU A 483
TYR A 449
 None
 0.60A 5igiA-1lnsA:
undetectable		 5igiA-1lnsA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mco IGG1 MCG INTACT
ANTIBODY (HEAVY
CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PRO H 229
HIS H 420
LEU H 391
TYR H 358
 GAL  H 435 (-4.8A)
None
None
None
 1.07A 5igiA-1mcoH:
undetectable		 5igiA-1mcoH:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjb L-ALANINE
DEHYDROGENASE

(Phormidium
lapideum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 HIS A 350
GLU A 117
LEU A  89
TYR A 319
 None
 1.06A 5igiA-1pjbA:
undetectable		 5igiA-1pjbA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1

(Mesorhizobium
loti) 		PF00797
(Acetyltransf_2) 		4 PRO A 138
GLU A 186
ALA A  86
LEU A   9
 None
 1.07A 5igiA-2bszA:
undetectable		 5igiA-2bszA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dxa PROTEIN YBAK

(Escherichia
coli) 		PF04073
(tRNA_edit) 		4 HIS A  18
ALA A   4
LEU A 106
TYR A  45
 None
 1.09A 5igiA-2dxaA:
undetectable		 5igiA-2dxaA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF11501
(Nsp1) 		4 GLU A  25
ALA A  31
LEU A  96
TYR A  86
 None
 1.06A 5igiA-2gdtA:
undetectable		 5igiA-2gdtA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E

(Pisum sativum) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		4 HIS A 310
GLU A 304
ALA A 431
LEU A 426
 None
 1.04A 5igiA-2h21A:
undetectable		 5igiA-2h21A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mri 26S PROTEASOME
REGULATORY SUBUNIT
RPN9

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		4 HIS A 235
GLU A 232
LEU A 222
TYR A 228
 None
 1.09A 5igiA-2mriA:
2.7		 5igiA-2mriA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1x 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Deinococcus
radiodurans) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		4 HIS A 117
ALA A  86
LEU A  37
TYR A  67
 None
 1.06A 5igiA-2o1xA:
undetectable		 5igiA-2o1xA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 PRO A 153
GLU A  57
ALA A  65
LEU A 128
 None
 0.98A 5igiA-2p3xA:
undetectable		 5igiA-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pok PEPTIDASE,
M20/M25/M40 FAMILY

(Streptococcus
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 PRO A 406
GLU A  61
ALA A  46
TYR A  66
 None
 1.07A 5igiA-2pokA:
undetectable		 5igiA-2pokA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pok PEPTIDASE,
M20/M25/M40 FAMILY

(Streptococcus
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 PRO A 406
GLU A  61
LEU A  42
TYR A  66
 None
 0.99A 5igiA-2pokA:
undetectable		 5igiA-2pokA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1

(Sulfolobus
solfataricus) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		4 PRO A  30
HIS A  35
GLU A 211
ALA A 242
 None
 1.09A 5igiA-2qbyA:
undetectable		 5igiA-2qbyA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wda PUTATIVE SECRETED
LYASE

(Streptomyces
violaceoruber) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 PRO A 494
ALA A 407
LEU A 400
TYR A 236
 GOL  A1771 (-4.3A)
None
GOL  A1772 (-4.3A)
PEG  A1779 (-4.4A)
 1.10A 5igiA-2wdaA:
undetectable		 5igiA-2wdaA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z00 DIHYDROOROTASE

(Thermus
thermophilus) 		PF01979
(Amidohydro_1) 		4 PRO A 309
ALA A 107
LEU A 115
TYR A  81
 None
 1.05A 5igiA-2z00A:
undetectable		 5igiA-2z00A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 PRO A 340
GLU A 161
ALA A 169
LEU A 329
 None
 1.04A 5igiA-2z7rA:
7.3		 5igiA-2z7rA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqo PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		no annotation 4 PRO A 216
GLU A 240
ALA A 168
LEU A 165
 None
 1.08A 5igiA-3aqoA:
undetectable		 5igiA-3aqoA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 HIS A 471
GLU A 206
ALA A 426
LEU A 429
 None
NDP  A 501 (-3.2A)
None
None
 1.04A 5igiA-3au9A:
undetectable		 5igiA-3au9A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA

(Chlorobaculum
tepidum) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 PRO A  44
GLU A 314
ALA A 330
LEU A 327
 None
 0.96A 5igiA-3cp8A:
undetectable		 5igiA-3cp8A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6k PUTATIVE
AMINOTRANSFERASE

(Corynebacterium
diphtheriae) 		PF12897
(Aminotran_MocR) 		4 HIS A 308
ALA A  85
LEU A  86
TYR A 219
 None
None
None
EDO  A 422 (-4.5A)
 0.98A 5igiA-3d6kA:
undetectable		 5igiA-3d6kA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3del ARGININE BINDING
PROTEIN

(Chlamydia
trachomatis) 		PF00497
(SBP_bac_3) 		4 GLU B  79
ALA B  64
LEU B  63
TYR B  44
 None
 1.04A 5igiA-3delB:
undetectable		 5igiA-3delB:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhu ALPHA-AMYLASE

(Lactobacillus
plantarum) 		PF00128
(Alpha-amylase) 		4 HIS A 332
ALA A 291
LEU A 295
TYR A 308
 None
 1.09A 5igiA-3dhuA:
undetectable		 5igiA-3dhuA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2s PUTATIVE NADH-FLAVIN
REDUCTASE

(Lactobacillus
paracasei) 		PF13460
(NAD_binding_10) 		4 HIS A  88
GLU A  57
ALA A   4
LEU A  28
 None
 0.89A 5igiA-3h2sA:
undetectable		 5igiA-3h2sA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 PRO B 246
ALA B 187
LEU B 205
TYR B 314
 None
 1.07A 5igiA-3hkzB:
undetectable		 5igiA-3hkzB:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 PRO A 274
GLU A 305
ALA A 327
LEU A 184
 None
 1.03A 5igiA-3hztA:
5.2		 5igiA-3hztA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		4 PRO A 211
GLU A 242
ALA A 264
LEU A 120
 None
 1.06A 5igiA-3kl8A:
8.1		 5igiA-3kl8A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 PRO A 196
HIS A 147
GLU A  66
ALA A 173
 None
 0.93A 5igiA-3mi9A:
8.0		 5igiA-3mi9A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mml ALLOPHANATE
HYDROLASE SUBUNIT 1
ALLOPHANATE
HYDROLASE SUBUNIT 2

(Mycolicibacterium
smegmatis) 		PF02626
(CT_A_B)
PF02682
(CT_C_D) 		4 PRO A 245
GLU A 266
ALA A 286
TYR B   9
 None
 1.08A 5igiA-3mmlA:
undetectable		 5igiA-3mmlA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3t PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE

(Thiobacillus
denitrificans) 		PF00563
(EAL) 		4 PRO A 662
GLU A 591
ALA A 598
LEU A 559
 None
 0.79A 5igiA-3n3tA:
undetectable		 5igiA-3n3tA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF02784
(Orn_Arg_deC_N) 		4 HIS A  98
GLU A 143
ALA A 364
LEU A 313
 None
 1.02A 5igiA-3nzqA:
undetectable		 5igiA-3nzqA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of5 DETHIOBIOTIN
SYNTHETASE

(Francisella
tularensis) 		PF13500
(AAA_26) 		4 PRO A  80
HIS A 126
ALA A 135
LEU A 136
 None
 0.98A 5igiA-3of5A:
undetectable		 5igiA-3of5A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 PRO A 265
GLU A 296
ALA A 318
LEU A 175
 None
 1.08A 5igiA-3q5iA:
7.0		 5igiA-3q5iA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qi6 CYSTATHIONINE
GAMMA-SYNTHASE METB
(CGS)

(Mycobacterium
ulcerans) 		PF01053
(Cys_Met_Meta_PP) 		4 PRO A 156
HIS A 265
GLU A 374
ALA A 271
 None
 1.10A 5igiA-3qi6A:
undetectable		 5igiA-3qi6A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thz DNA MISMATCH REPAIR
PROTEIN MSH2

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 GLU A 749
ALA A 309
LEU A 310
TYR A 678
 None
 0.98A 5igiA-3thzA:
2.8		 5igiA-3thzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 PRO A 633
GLU A 453
ALA A 461
LEU A 622
 None
 0.99A 5igiA-3txoA:
8.3		 5igiA-3txoA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uaq LBPB B-LOBE

(Moraxella bovis) 		PF01298
(TbpB_B_D)
PF17484
(TbpB_A) 		4 GLU A 320
ALA A 238
LEU A 253
TYR A 157
 None
 1.09A 5igiA-3uaqA:
undetectable		 5igiA-3uaqA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up4 OTEMO

(Pseudomonas
putida) 		PF00743
(FMO-like) 		4 PRO A 145
HIS A 520
GLU A 526
LEU A 289
 FAD  A 551 ( 4.3A)
None
None
None
 0.99A 5igiA-3up4A:
undetectable		 5igiA-3up4A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 PRO A 293
GLU A  73
ALA A  25
LEU A  66
 None
 1.00A 5igiA-3w15A:
undetectable		 5igiA-3w15A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		4 PRO A 583
HIS A 306
ALA A 238
LEU A 275
 None
 0.96A 5igiA-3wnpA:
undetectable		 5igiA-3wnpA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		4 HIS A1944
GLU A1746
ALA A1847
LEU A1846
 None
 1.10A 5igiA-4asiA:
undetectable		 5igiA-4asiA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		no annotation 4 HIS A 245
ALA A 256
LEU A 270
TYR A 222
 None
 1.08A 5igiA-4czxA:
undetectable		 5igiA-4czxA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5g CYCLOHEXANE-1,2-DION
E HYDROLASE

(Azoarcus sp.
BH72) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 PRO A 296
GLU A 248
ALA A 229
LEU A 228
 None
 0.97A 5igiA-4d5gA:
undetectable		 5igiA-4d5gA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE

(Chromobacterium
violaceum) 		PF01979
(Amidohydro_1) 		4 PRO A 194
HIS A  70
GLU A 320
LEU A 295
 None
 1.00A 5igiA-4f0sA:
undetectable		 5igiA-4f0sA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxq PUTATIVE
ADP-RIBOSYLTRANSFERA
SE CERTHRAX

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox)
PF07737
(ATLF) 		4 GLU A 266
ALA A 327
LEU A 328
TYR A 419
 None
 0.97A 5igiA-4fxqA:
undetectable		 5igiA-4fxqA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpc HEME OXYGENASE

(Corynebacterium
diphtheriae) 		PF01126
(Heme_oxygenase) 		4 HIS A  20
ALA A   9
LEU A 180
TYR A 133
 BLA  A 901 (-3.7A)
None
None
None
 1.09A 5igiA-4gpcA:
undetectable		 5igiA-4gpcA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr5 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
lydicus) 		PF00501
(AMP-binding)
PF03621
(MbtH) 		4 HIS A 128
GLU A 130
ALA A 138
LEU A 110
 None
 1.10A 5igiA-4gr5A:
undetectable		 5igiA-4gr5A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Haemophilus
influenzae) 		PF01546
(Peptidase_M20) 		4 HIS A 257
GLU A 254
ALA A 106
LEU A   8
 None
 1.01A 5igiA-4h2kA:
undetectable		 5igiA-4h2kA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED

(Xanthomonas
oryzae) 		PF01053
(Cys_Met_Meta_PP) 		4 PRO B 158
HIS B 268
GLU B 380
ALA B 274
 None
 1.08A 5igiA-4iyoB:
undetectable		 5igiA-4iyoB:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxr ACETYLTRANSFERASE

(Sinorhizobium
meliloti) 		PF13420
(Acetyltransf_4) 		4 GLU A  93
ALA A   3
LEU A   5
TYR A  68
 None
 1.07A 5igiA-4jxrA:
undetectable		 5igiA-4jxrA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k02 1,4-DIHYDROXY-2-NAPH
THOYL-COA
THIOESTERASE

(Arabidopsis
thaliana) 		PF03061
(4HBT) 		4 PRO A  14
GLU A  95
ALA A  64
LEU A 133
 None
 1.04A 5igiA-4k02A:
undetectable		 5igiA-4k02A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k73 L,D-TRANSPEPTIDASE

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		4 PRO A 125
GLU A 190
ALA A 254
LEU A 249
 None
 1.03A 5igiA-4k73A:
undetectable		 5igiA-4k73A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1

(Rattus
norvegicus) 		PF04495
(GRASP55_65) 		4 HIS A  17
GLU A  33
LEU A 162
TYR A 134
 ZN  A 301 ( 3.4A)
None
None
None
 1.00A 5igiA-4kfvA:
undetectable		 5igiA-4kfvA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdv ANNEXIN

(Schistosoma
mansoni) 		PF00191
(Annexin) 		5 PRO A  21
HIS A 212
GLU A 213
ALA A 219
LEU A 222
 None
 1.37A 5igiA-4mdvA:
undetectable		 5igiA-4mdvA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhp GLUTAMINYL CYCLASE,
PUTATIVE

(Ixodes
scapularis) 		PF04389
(Peptidase_M28) 		4 PRO A 318
HIS A 128
ALA A 150
LEU A  60
 None
 1.02A 5igiA-4mhpA:
undetectable		 5igiA-4mhpA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 PRO A 120
GLU A  80
ALA A 361
LEU A 360
 None
 1.06A 5igiA-4mrmA:
undetectable		 5igiA-4mrmA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4px9 ATP-DEPENDENT RNA
HELICASE DDX3X

(Homo sapiens) 		PF00270
(DEAD) 		4 GLU A 284
ALA A 232
LEU A 236
TYR A 291
 None
 1.07A 5igiA-4px9A:
undetectable		 5igiA-4px9A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnl POSSIBLE GALACTOSE
MUTAROTASE

(Streptomyces
platensis) 		PF01263
(Aldose_epim) 		4 PRO A 310
ALA A 256
LEU A 269
TYR A 181
 None
 1.03A 5igiA-4rnlA:
undetectable		 5igiA-4rnlA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trq NUCLEAR MRNA EXPORT
PROTEIN SAC3
NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF03399
(SAC3_GANP) 		4 PRO B 339
GLU B 387
ALA A 399
LEU A 370
 None
 1.03A 5igiA-4trqB:
undetectable		 5igiA-4trqB:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9c LACTOFERRIN-BINDING
PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17484
(TbpB_A) 		4 GLU A 323
ALA A 234
LEU A 249
TYR A 165
 None
 1.05A 5igiA-4u9cA:
undetectable		 5igiA-4u9cA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whn APXC

(Actinobacillus
pleuropneumoniae) 		PF02794
(HlyC) 		4 PRO A  54
HIS A  24
ALA A  33
LEU A  37
 None
 1.06A 5igiA-4whnA:
undetectable		 5igiA-4whnA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xq7 2'-5'-OLIGOADENYLATE
SYNTHASE-LIKE
PROTEIN

(Homo sapiens) 		PF10421
(OAS1_C) 		4 PRO A 306
GLU A 299
LEU A 267
TYR A 317
 None
 0.97A 5igiA-4xq7A:
undetectable		 5igiA-4xq7A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y67 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE,
APICOPLAST

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 HIS A 471
GLU A 206
ALA A 426
LEU A 429
 None
 1.04A 5igiA-4y67A:
undetectable		 5igiA-4y67A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yac C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		4 PRO A 187
GLU A  28
ALA A   9
LEU A  87
 None
 1.05A 5igiA-4yacA:
undetectable		 5igiA-4yacA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3y BENZOYL-COA
REDUCTASE, PUTATIVE

(Geobacter
metallireducens) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		4 PRO A 486
GLU A 453
ALA A 530
LEU A  33
 None
 0.84A 5igiA-4z3yA:
2.4		 5igiA-4z3yA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 HIS A 921
GLU A 571
ALA A 579
TYR A 564
 None
 0.96A 5igiA-4zdnA:
undetectable		 5igiA-4zdnA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aq1 GLUCOSE-6-PHOSPHATE
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		4 PRO A 378
HIS A 511
GLU A 224
ALA A 502
 None
 1.09A 5igiA-5aq1A:
undetectable		 5igiA-5aq1A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bug PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
3-PHOSPHATASE AND
DUAL-SPECIFICITY
PROTEIN PHOSPHATASE
PTEN

(Homo sapiens) 		PF00782
(DSPc)
PF10409
(PTEN_C2) 		4 PRO A 283
ALA A 151
LEU A 152
TYR A 174
 None
 1.00A 5igiA-5bugA:
undetectable		 5igiA-5bugA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7j ATP-DEPENDENT RNA
HELICASE DDX3X

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLU A 284
ALA A 232
LEU A 236
TYR A 291
 None
AMP  A 801 ( 4.3A)
None
None
 1.03A 5igiA-5e7jA:
undetectable		 5igiA-5e7jA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f05 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF5

(Populus
trichocarpa) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 PRO A  56
HIS A 168
ALA A 203
TYR A  79
 GSH  A 301 ( 4.6A)
None
None
None
 1.00A 5igiA-5f05A:
undetectable		 5igiA-5f05A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fei DISTAL TUBE PROTEIN

(Bacillus virus
phi29) 		PF16838
(Caud_tail_N) 		4 GLU A 110
ALA A  75
LEU A  72
TYR A  62
 None
 1.04A 5igiA-5feiA:
undetectable		 5igiA-5feiA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG

(Caenorhabditis
elegans) 		PF03159
(XRN_N) 		4 GLU A  76
ALA A 174
LEU A 175
TYR A  84
 None
 1.03A 5igiA-5firA:
undetectable		 5igiA-5firA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkq ALYGC MUTANT - R241A

(Paraglaciecola
chathamensis) 		PF14592
(Chondroitinas_B) 		5 PRO A 691
GLU A 611
ALA A 623
LEU A 593
TYR A 607
 None
 1.46A 5igiA-5gkqA:
undetectable		 5igiA-5gkqA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE

(Thermococcus
kodakarensis) 		PF02449
(Glyco_hydro_42) 		4 HIS A 335
ALA A 440
LEU A 504
TYR A 444
 None
 1.06A 5igiA-5gsmA:
undetectable		 5igiA-5gsmA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i0p BETA-LACTAMASE
DOMAIN PROTEIN

(Burkholderia
ambifaria) 		PF00753
(Lactamase_B) 		4 HIS A 347
GLU A 242
ALA A 305
LEU A 327
 None
 1.10A 5igiA-5i0pA:
undetectable		 5igiA-5i0pA:
23.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E

(Escherichia
coli) 		PF01636
(APH) 		6 PRO A 112
HIS A 205
GLU A 222
ALA A 233
LEU A 270
TYR A 277
 ERY  A 402 ( 4.1A)
GDP  A 401 (-4.4A)
ERY  A 402 ( 3.9A)
ERY  A 402 ( 3.9A)
None
ERY  A 402 ( 4.5A)
 0.00A 5igiA-5igpA:
47.5		 5igiA-5igpA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR

(Mus musculus) 		no annotation 4 PRO B 170
GLU B 137
ALA B 221
TYR B 228
 None
 1.06A 5igiA-5lhsB:
undetectable		 5igiA-5lhsB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lva NAD(P)H-FMN
OXIDOREDUCTASE

(Bacillus
subtilis) 		PF02525
(Flavodoxin_2) 		4 GLU A 112
ALA A 107
LEU A  66
TYR A 122
 None
FMN  A 201 (-3.3A)
FMN  A 201 (-4.4A)
None
 0.95A 5igiA-5lvaA:
undetectable		 5igiA-5lvaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6k POLYPHOSPHATE:AMP
PHOSPHOTRANSFERASE

(Meiothermus
ruber) 		no annotation 4 HIS A 124
ALA A  64
LEU A 168
TYR A 225
 None
PO4  A 301 ( 4.8A)
None
None
 0.99A 5igiA-5o6kA:
undetectable		 5igiA-5o6kA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thm ESTERASE-6

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 PRO A 220
HIS A 445
LEU A 327
TYR A 273
 None
7BZ  A 601 (-3.8A)
None
None
 1.10A 5igiA-5thmA:
undetectable		 5igiA-5thmA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Neisseria
gonorrhoeae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 PRO A  80
GLU A 143
ALA A 148
LEU A 323
 None
 0.93A 5igiA-5vmtA:
undetectable		 5igiA-5vmtA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S13,
PUTATIVE

(Trichomonas
vaginalis) 		PF00312
(Ribosomal_S15)
PF08069
(Ribosomal_S13_N) 		4 HIS N  90
GLU N  87
ALA N  81
LEU N  75
 G  2 689 ( 3.5A)
G  2 687 ( 3.9A)
U  2 658 ( 3.7A)
None
 1.02A 5igiA-5xyiN:
2.3		 5igiA-5xyiN:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y10 MEMBRANE
GLYCOPROTEIN
POLYPROTEIN

(SFTS
phlebovirus) 		PF07243
(Phlebovirus_G1) 		4 PRO C 265
HIS C  40
ALA C 101
LEU C  96
 None
NAG  C 402 (-4.6A)
None
None
 1.06A 5igiA-5y10C:
undetectable		 5igiA-5y10C:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpc RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 4 HIS A 222
GLU A 219
LEU A 307
TYR A 211
 None
 1.07A 5igiA-6bpcA:
undetectable		 5igiA-6bpcA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byx SHORT ULVAN LYASE

(Alteromonas sp.
LOR) 		no annotation 4 PRO A 244
HIS A 133
ALA A  54
LEU A 511
 None
 1.05A 5igiA-6byxA:
undetectable		 5igiA-6byxA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c29 PUTATIVE METAL
RESISTANCE PROTEIN

(Proteus
mirabilis) 		no annotation 4 PRO A  56
HIS A  70
ALA A  22
LEU A 127
 None
 1.06A 5igiA-6c29A:
undetectable		 5igiA-6c29A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d04 RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 4 PRO E 411
GLU E 204
LEU E 307
TYR E 211
 None
 0.92A 5igiA-6d04E:
undetectable		 5igiA-6d04E:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epe PROTEASOME (PROSOME,
MACROPAIN) 26S
SUBUNIT, NON-ATPASE,
7 (PREDICTED)

(Rattus
norvegicus) 		no annotation 4 PRO U 134
HIS U  96
GLU U  60
ALA U  55
 None
 1.00A 5igiA-6epeU:
undetectable		 5igiA-6epeU:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 4 HIS A2308
GLU A2357
ALA A2396
LEU A2452
 None
 1.05A 5igiA-6ez8A:
undetectable		 5igiA-6ez8A:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5z 24-STEROL
C-METHYLTRANSFERASE

(Haloferax
volcanii) 		no annotation 4 HIS A 165
ALA A 171
LEU A 123
TYR A 114
 None
 1.04A 5igiA-6f5zA:
undetectable		 5igiA-6f5zA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5z 24-STEROL
C-METHYLTRANSFERASE

(Haloferax
volcanii) 		no annotation 4 HIS A 165
GLU A 144
ALA A 171
TYR A 114
 None
 0.86A 5igiA-6f5zA:
undetectable		 5igiA-6f5zA:
13.67