SIMILAR PATTERNS OF AMINO ACIDS FOR 5IGI_A_ZITA402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1al8 GLYCOLATE OXIDASE

(Spinacia
oleracea) 		PF01070
(FMN_dh) 		5 MET A  74
ILE A 102
VAL A 305
ALA A 302
GLY A 278
 None
 1.06A 5igiA-1al8A:
0.0		 5igiA-1al8A:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aug PYROGLUTAMYL
PEPTIDASE-1

(Bacillus
amyloliquefaciens) 		PF01470
(Peptidase_C15) 		5 ASP A 206
ALA A 200
VAL A 198
GLY A 165
THR A 115
 None
 1.25A 5igiA-1augA:
0.0		 5igiA-1augA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coy CHOLESTEROL OXIDASE

(Brevibacterium
sterolicum) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ILE A  39
ALA A 494
MET A 498
GLY A 462
THR A 458
 None
 1.27A 5igiA-1coyA:
0.0		 5igiA-1coyA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 VAL A 362
ALA A 280
VAL A 417
GLY A 328
PHE A 314
 None
 1.25A 5igiA-1ezvA:
0.0		 5igiA-1ezvA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpw CALCIUM-BINDING
PROTEIN NCS-1

(Saccharomyces
cerevisiae) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		5 MET A 121
ILE A 116
ASP A 187
VAL A 125
ALA A 182
 None
CA  A 501 (-4.6A)
None
None
None
 0.99A 5igiA-1fpwA:
undetectable		 5igiA-1fpwA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdg HOLO-D-GLYCERALDEHYD
E-3-PHOSPHATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ILE O 167
ALA O 262
MET O 259
VAL O 258
GLY O 272
 None
 1.25A 5igiA-1hdgO:
0.0		 5igiA-1hdgO:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hrd GLUTAMATE
DEHYDROGENASE

([Clostridium]
symbiosum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 ILE A  53
ASP A  17
TYR A  15
VAL A  11
VAL A  25
 None
 0.99A 5igiA-1hrdA:
undetectable		 5igiA-1hrdA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE

(Neurospora
crassa) 		PF10282
(Lactonase) 		5 ASP A 329
ALA A 313
VAL A 259
THR A 306
PHE A 278
 None
 1.24A 5igiA-1jofA:
0.0		 5igiA-1jofA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		5 ILE A  32
VAL A 131
VAL A  89
GLY A 138
THR A 156
 None
 1.24A 5igiA-1kb0A:
undetectable		 5igiA-1kb0A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		5 ILE A 581
ASP A 689
VAL A 550
GLY A 243
THR A 242
 None
 1.18A 5igiA-1l5jA:
0.0		 5igiA-1l5jA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw9 DNA TOPOISOMERASE I

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 VAL X 510
ALA X 200
VAL X 204
GLY X 492
THR X 496
 None
 1.25A 5igiA-1mw9X:
undetectable		 5igiA-1mw9X:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 ILE A 136
TYR A 158
ALA A 161
VAL A 141
GLY A 148
 None
 1.20A 5igiA-1oi7A:
undetectable		 5igiA-1oi7A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1osg TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B

(Homo sapiens) 		PF00229
(TNF) 		5 ILE A 212
VAL A 199
ALA A 151
VAL A 166
PHE A 172
 None
 1.02A 5igiA-1osgA:
undetectable		 5igiA-1osgA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgc PROTEIN (VIRUS
CAPSID PROTEIN VP1)
PROTEIN (VIRUS
CAPSID PROTEIN VP2)

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		5 ILE 2 197
VAL 2 109
VAL 2 123
GLY 1   5
THR 1   4
 None
 1.03A 5igiA-1qgc2:
undetectable		 5igiA-1qgc2:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)

(Burkholderia
glumae) 		PF00561
(Abhydrolase_1) 		5 ILE D 214
ALA D 141
VAL D 138
GLY D 147
THR D 148
 None
 1.11A 5igiA-1qgeD:
undetectable		 5igiA-1qgeD:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqb TRANSCARBOXYLASE 5S
SUBUNIT

(Propionibacterium
freudenreichii) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 ASP A 185
VAL A 238
VAL A 257
GLY A 221
THR A 220
 None
 1.23A 5igiA-1rqbA:
undetectable		 5igiA-1rqbA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tah LIPASE

(Burkholderia
glumae) 		no annotation 5 ILE B 214
ALA B 141
VAL B 138
GLY B 147
THR B 148
 None
 1.17A 5igiA-1tahB:
undetectable		 5igiA-1tahB:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN

(Aquifex
aeolicus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ILE A  51
VAL A  29
ALA A  74
VAL A  72
GLY A  98
 None
 0.95A 5igiA-1ulzA:
undetectable		 5igiA-1ulzA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5e FTSZ

(Methanocaldococcus
jannaschii) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 ILE A 150
VAL A  67
GLY A  63
THR A 227
PHE A 236
 None
 1.23A 5igiA-1w5eA:
undetectable		 5igiA-1w5eA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zly PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Homo sapiens) 		PF00551
(Formyl_trans_N) 		5 ILE A 107
ALA A  28
VAL A   3
GLY A 187
THR A 188
 GRF  A1300 (-4.5A)
None
None
None
None
 1.20A 5igiA-1zlyA:
undetectable		 5igiA-1zlyA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azp HYPOTHETICAL PROTEIN
PA1268

(Pseudomonas
aeruginosa) 		PF05544
(Pro_racemase) 		5 ILE A 198
VAL A 189
VAL A 167
GLY A 239
THR A 238
 None
 1.22A 5igiA-2azpA:
undetectable		 5igiA-2azpA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5

(Homo sapiens) 		PF00149
(Metallophos) 		5 ILE X 131
VAL X 274
ALA X 272
VAL X 235
GLY X 240
 None
 1.18A 5igiA-2bq8X:
undetectable		 5igiA-2bq8X:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9y PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
PROTEIN FAMILY A
MEMBER 6

(Homo sapiens) 		PF00169
(PH) 		5 ILE A  51
VAL A  11
GLY A 105
PHE A  60
TYR A  87
 None
 1.26A 5igiA-2d9yA:
undetectable		 5igiA-2d9yA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00202
(Aminotran_3) 		5 VAL A 124
VAL A 250
GLY A 141
THR A 143
PHE A 144
 None
None
PLP  A1001 ( 4.2A)
None
None
 1.21A 5igiA-2eo5A:
undetectable		 5igiA-2eo5A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5v PYRANOSE 2-OXIDASE

(Peniophora sp.
SG) 		PF05199
(GMC_oxred_C) 		5 ILE A 295
ALA A 320
VAL A  52
GLY A 584
THR A 552
 None
FAD  A1625 (-3.6A)
FAD  A1625 (-4.8A)
None
None
 1.22A 5igiA-2f5vA:
undetectable		 5igiA-2f5vA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fep CATABOLITE CONTROL
PROTEIN A

(Bacillus
subtilis) 		PF13377
(Peripla_BP_3) 		5 VAL A 184
ALA A 252
THR A 278
PHE A  75
TYR A  76
 None
None
SO4  A4396 (-2.9A)
SO4  A4397 ( 3.2A)
SO4  A4397 (-4.5A)
 1.25A 5igiA-2fepA:
undetectable		 5igiA-2fepA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Lactococcus
lactis) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 ALA A 172
MET A 174
GLY A 356
THR A 377
TYR A 335
 None
 1.11A 5igiA-2iyoA:
1.2		 5igiA-2iyoA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ldx APO-LACTATE
DEHYDROGENASE

(Mus musculus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A 199
VAL A 303
VAL A 269
GLY A 159
THR A 143
 None
 1.08A 5igiA-2ldxA:
undetectable		 5igiA-2ldxA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o56 PUTATIVE MANDELATE
RACEMASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 344
VAL A 214
ALA A 158
VAL A 162
GLY A 138
 None
 1.22A 5igiA-2o56A:
undetectable		 5igiA-2o56A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w40 GLYCEROL KINASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 MET A 211
GLY A 129
THR A 130
PHE A 132
TYR A 119
 None
None
EDO  A1506 (-4.1A)
None
EDO  A1509 (-4.8A)
 1.21A 5igiA-2w40A:
undetectable		 5igiA-2w40A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ILE A 214
VAL A 157
ALA A 290
VAL A 309
GLY A 316
 None
 1.01A 5igiA-2xf8A:
undetectable		 5igiA-2xf8A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhg CELLULOSE-BINDING
PROTEIN

(Saccharophagus
degradans) 		PF07632
(DUF1593) 		5 ASP A 685
ALA A 654
VAL A 657
GLY A 609
THR A 561
 None
 1.25A 5igiA-2yhgA:
undetectable		 5igiA-2yhgA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Thermus
thermophilus) 		PF00117
(GATase)
PF00958
(GMP_synt_C) 		5 ILE A  15
ALA A 184
VAL A 186
GLY A  71
PHE A  68
 None
 1.19A 5igiA-2ywbA:
undetectable		 5igiA-2ywbA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zal L-ASPARAGINASE

(Escherichia
coli) 		PF01112
(Asparaginase_2) 		5 VAL B 214
ALA A  96
MET A 121
VAL A 120
GLY A  99
 None
 1.25A 5igiA-2zalB:
undetectable		 5igiA-2zalB:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cl6 PUUE ALLANTOINASE

(Pseudomonas
fluorescens) 		PF01522
(Polysacc_deac_1) 		5 ILE A  86
VAL A 112
ALA A 106
GLY A 127
TYR A 211
 None
 1.06A 5igiA-3cl6A:
undetectable		 5igiA-3cl6A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e53 FATTY-ACID-COA
LIGASE FADD28

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		5 ILE A 457
ASP A 222
VAL A 338
ALA A 334
VAL A 405
 None
 1.12A 5igiA-3e53A:
undetectable		 5igiA-3e53A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e53 FATTY-ACID-COA
LIGASE FADD28

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		5 ILE A 457
VAL A 338
ALA A 334
VAL A 405
THR A 171
 None
 1.23A 5igiA-3e53A:
undetectable		 5igiA-3e53A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e74 ALLANTOINASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		5 ILE A 418
ALA A 336
GLY A  76
THR A  75
TYR A 433
 None
 0.94A 5igiA-3e74A:
undetectable		 5igiA-3e74A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 214
VAL A 118
ALA A 113
VAL A 159
GLY A  33
 None
None
35F  A   1 (-4.9A)
None
35F  A   1 ( 4.8A)
 1.10A 5igiA-3e7oA:
7.3		 5igiA-3e7oA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE

(Listeria
innocua) 		PF06838
(Met_gamma_lyase) 		5 VAL A 387
ALA A 331
MET A 327
GLY A 348
TYR A 354
 None
 1.10A 5igiA-3fd0A:
undetectable		 5igiA-3fd0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juj UDP-GLUCOSE
PYROPHOSPHORYLASE
(GALU)

(Helicobacter
pylori) 		PF00483
(NTP_transferase) 		5 ILE A 230
ALA A  10
VAL A  54
GLY A  13
THR A  14
 None
 1.09A 5igiA-3jujA:
undetectable		 5igiA-3jujA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n79 PDUT

(Salmonella
enterica) 		PF00936
(BMC) 		5 ILE A 109
ASP A  70
VAL A  33
GLY A  60
THR A  61
 None
 1.23A 5igiA-3n79A:
undetectable		 5igiA-3n79A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhi D7 PROTEIN

(Anopheles
stephensi) 		PF01395
(PBP_GOBP) 		5 ILE A  75
TYR A 117
VAL A 120
ALA A 116
GLY A 108
 None
EAH  A   1 (-4.6A)
None
None
None
 1.07A 5igiA-3nhiA:
1.7		 5igiA-3nhiA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p41 GERANYLTRANSTRANSFER
ASE

(Pseudomonas
protegens) 		PF00348
(polyprenyl_synt) 		5 ASP A 222
VAL A 291
ALA A 217
GLY A 182
THR A 181
 None
 1.11A 5igiA-3p41A:
undetectable		 5igiA-3p41A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpc POSSIBLE
METAL-DEPENDENT
HYDROLASE

(Veillonella
parvula) 		PF12706
(Lactamase_B_2) 		5 MET A 186
ILE A 219
VAL A 163
ALA A 175
VAL A 172
 None
 1.10A 5igiA-3rpcA:
undetectable		 5igiA-3rpcA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7i FMN-DEPENDENT
NADH-AZOREDUCTASE 1

(Bacillus
anthracis) 		PF02525
(Flavodoxin_2) 		5 ILE A  85
VAL A  78
ALA A  61
VAL A  58
GLY A  66
 None
 1.26A 5igiA-3u7iA:
undetectable		 5igiA-3u7iA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti) 		PF00294
(PfkB) 		5 ILE A 211
VAL A   6
ALA A  65
VAL A  68
GLY A  59
 None
None
None
None
ADN  A 353 (-3.2A)
 1.08A 5igiA-3uboA:
undetectable		 5igiA-3uboA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgl GLUCOKINASE

(Streptomyces
griseus) 		PF00480
(ROK) 		5 ILE A  44
VAL A 102
VAL A  75
GLY A 135
THR A 129
 None
None
None
BGC  A 324 (-3.5A)
None
 1.22A 5igiA-3vglA:
undetectable		 5igiA-3vglA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vs8 TYPE III POLYKETIDE
SYNTHASE

(Azotobacter
vinelandii) 		PF02797
(Chal_sti_synt_C) 		5 VAL A 178
ALA A 164
MET A 167
VAL A 168
GLY A 135
 None
 1.02A 5igiA-3vs8A:
undetectable		 5igiA-3vs8A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu2 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 ILE A 211
ASP A 270
VAL A 267
VAL A 257
PHE A 233
 None
 1.23A 5igiA-3vu2A:
undetectable		 5igiA-3vu2A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00348
(polyprenyl_synt) 		6 ILE A   2
ASP A 222
VAL A 291
ALA A 217
GLY A 182
THR A 181
 6H6  A1299 ( 4.1A)
None
None
None
None
None
 1.25A 5igiA-3zouA:
undetectable		 5igiA-3zouA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1

(Homo sapiens) 		PF00753
(Lactamase_B)
PF12706
(Lactamase_B_2) 		5 ILE A 359
VAL A 310
GLY A 252
THR A  61
PHE A  59
 None
 1.11A 5igiA-3zwfA:
undetectable		 5igiA-3zwfA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgv MALATE DEHYDROGENASE

(Picrophilus
torridus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ALA A 258
VAL A 286
GLY A 151
PHE A 188
TYR A 191
 None
 1.09A 5igiA-4bgvA:
undetectable		 5igiA-4bgvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE

(Methanocaldococcus
jannaschii) 		PF00464
(SHMT) 		5 ILE A 132
ASP A 196
ALA A 113
VAL A 137
GLY A 119
 None
 1.03A 5igiA-4bhdA:
0.2		 5igiA-4bhdA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw4 BETA-KETOACYL
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A 292
VAL A   6
ALA A 550
MET A 553
THR A 424
 None
 1.12A 5igiA-4cw4A:
undetectable		 5igiA-4cw4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3a SUGAR KINASE PROTEIN

(Rhizobium etli) 		PF00294
(PfkB) 		5 ILE A 209
VAL A   4
ALA A  63
VAL A  66
GLY A  57
 None
None
None
None
ADN  A 500 (-3.7A)
 1.06A 5igiA-4e3aA:
undetectable		 5igiA-4e3aA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es7 PROTEIN AMBP

(Homo sapiens) 		PF00061
(Lipocalin) 		5 MET A 156
ILE A  23
VAL A  39
GLY A  16
TYR A  72
 None
 1.13A 5igiA-4es7A:
undetectable		 5igiA-4es7A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exj UNCHARACTERIZED
PROTEIN

(Lodderomyces
elongisporus) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 ILE A  69
VAL A  17
VAL A 168
PHE A  31
TYR A  43
 None
 1.19A 5igiA-4exjA:
undetectable		 5igiA-4exjA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		5 ILE A 298
VAL A 277
GLY A 470
THR A 474
PHE A 475
 ILE  A 298 ( 0.7A)
VAL  A 277 ( 0.6A)
GLY  A 470 ( 0.0A)
THR  A 474 ( 0.8A)
PHE  A 475 ( 1.3A)
 1.22A 5igiA-4g9kA:
undetectable		 5igiA-4g9kA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gh4 CAPSID PROTEIN VP1
CAPSID PROTEIN VP2

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		5 ILE B 197
VAL B 109
VAL B 123
GLY A   5
THR A   4
 None
 1.04A 5igiA-4gh4B:
undetectable		 5igiA-4gh4B:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyd PUTATIVE
UNCHARACTERIZED
PROTEIN

(Methanoculleus
marisnigri) 		PF06550
(SPP) 		5 ILE A 222
MET A  30
VAL A  27
GLY A  90
PHE A  85
 None
 1.23A 5igiA-4hydA:
undetectable		 5igiA-4hydA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix8 TYROSINE
AMINOTRANSFERASE

(Leishmania
infantum) 		PF00155
(Aminotran_1_2) 		5 ILE A 154
VAL A 170
ALA A 172
GLY A 412
PHE A 378
 None
 1.23A 5igiA-4ix8A:
undetectable		 5igiA-4ix8A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn7 ENOLASE

(Agrobacterium
tumefaciens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 MET A 275
ILE A 266
ALA A 282
PHE A 214
TYR A 120
 None
 1.25A 5igiA-4jn7A:
undetectable		 5igiA-4jn7A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvl FATTY ACID
ALPHA-OXIDASE

(Oryza sativa) 		PF03098
(An_peroxidase) 		5 ILE A 519
ASP A 471
VAL A 177
ALA A 173
GLY A 170
 None
 1.24A 5igiA-4kvlA:
undetectable		 5igiA-4kvlA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxi MCP HYDROLASE

(Sphingomonas
wittichii) 		PF12697
(Abhydrolase_6) 		5 MET A 258
VAL A 257
GLY A  40
PHE A  65
TYR A 193
 None
 1.24A 5igiA-4lxiA:
undetectable		 5igiA-4lxiA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1r CELLULASE 5

(soil metagenome) 		PF00150
(Cellulase) 		5 ASP A  95
ALA A 101
GLY A 165
THR A 190
TYR A 194
 None
 1.20A 5igiA-4m1rA:
undetectable		 5igiA-4m1rA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mae METHANOL
DEHYDROGENASE

(Methylacidiphilum
fumariolicum) 		PF13360
(PQQ_2) 		5 ILE A 508
VAL A 107
ALA A 103
GLY A 171
THR A 236
 None
None
None
PQQ  A 602 (-3.1A)
PQQ  A 602 (-3.1A)
 1.19A 5igiA-4maeA:
undetectable		 5igiA-4maeA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3r ARGINASE

(Schistosoma
mansoni) 		PF00491
(Arginase) 		5 ILE A 290
ASP A 158
ALA A 306
GLY A 275
THR A 276
 None
MN  A 401 ( 2.5A)
None
None
XA2  A 407 (-3.6A)
 1.10A 5igiA-4q3rA:
undetectable		 5igiA-4q3rA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA

(Escherichia
coli) 		PF03611
(EIIC-GAT) 		5 ILE A 192
TYR A 319
VAL A 287
GLY A  60
THR A  63
 None
 1.17A 5igiA-4rp8A:
undetectable		 5igiA-4rp8A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)

(Agrobacterium
vitis) 		PF01547
(SBP_bac_1) 		5 ILE A 369
ASP A 262
ALA A 198
VAL A 387
GLY A 190
 None
None
None
None
MTL  A 501 (-3.6A)
 1.20A 5igiA-4ryaA:
undetectable		 5igiA-4ryaA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		5 VAL A  29
ALA A  42
VAL A  46
THR A 184
PHE A 178
 None
 1.22A 5igiA-4u1rA:
undetectable		 5igiA-4u1rA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wct FRUCTOSYL
AMINE:OXYGEN
OXIDOREDUCTASE

(Aspergillus
fumigatus) 		PF01266
(DAO) 		5 MET A 248
ILE A 246
TYR A 256
VAL A 253
THR A 138
 None
 1.23A 5igiA-4wctA:
undetectable		 5igiA-4wctA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Pseudomonas
aeruginosa) 		PF02540
(NAD_synthase) 		5 ALA A 155
VAL A 151
GLY A 162
THR A  46
PHE A  82
 None
 1.15A 5igiA-4xfdA:
undetectable		 5igiA-4xfdA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zch TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B

(Homo sapiens) 		PF00229
(TNF) 		5 ILE A 371
VAL A 358
ALA A 310
VAL A 325
PHE A 331
 None
 1.05A 5igiA-4zchA:
undetectable		 5igiA-4zchA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zn6 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Acinetobacter
baumannii) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 ILE A  54
VAL A  63
VAL A  65
GLY A 115
THR A 119
 None
 1.25A 5igiA-4zn6A:
0.6		 5igiA-4zn6A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2d HN PROTEIN

(Mumps
rubulavirus) 		PF00423
(HN) 		5 TYR A 258
VAL A 259
GLY A 270
PHE A 370
TYR A 369
 None
None
None
SLT  A 606 (-4.6A)
SLT  A 606 (-4.2A)
 1.19A 5igiA-5b2dA:
undetectable		 5igiA-5b2dA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9n B-1,4-ENDOGLUCANASE

(Prevotella
bryantii) 		PF00150
(Cellulase) 		5 VAL A  97
ALA A 107
VAL A 109
GLY A  23
PHE A 328
 None
 1.13A 5igiA-5d9nA:
undetectable		 5igiA-5d9nA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 ILE A 538
VAL A 571
ALA A 575
GLY A 531
THR A 509
 None
 1.14A 5igiA-5dmyA:
undetectable		 5igiA-5dmyA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eu0 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS

(Bartonella
rochalimae) 		PF02661
(Fic) 		5 ILE A 156
MET A 205
VAL A 208
GLY A 177
PHE A 183
 None
None
None
SO4  A 301 (-3.7A)
None
 1.15A 5igiA-5eu0A:
undetectable		 5igiA-5eu0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5feu NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE

(Narcissus
pseudonarcissus) 		PF13561
(adh_short_C2) 		5 VAL A  42
ALA A  28
VAL A  30
GLY A 155
THR A 154
 None
 1.25A 5igiA-5feuA:
undetectable		 5igiA-5feuA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghs SSDNA-SPECIFIC
EXONUCLEASE

(Thermococcus
kodakarensis) 		PF02272
(DHHA1) 		5 ILE A  21
ALA A 104
VAL A 102
GLY A  37
THR A  39
 None
 1.13A 5igiA-5ghsA:
undetectable		 5igiA-5ghsA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h82 HETEROYOHIMBINE
SYNTHASE THAS2

(Catharanthus
roseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 MET A 341
ILE A 364
ASP A  51
ALA A  16
THR A 124
 None
 1.24A 5igiA-5h82A:
undetectable		 5igiA-5h82A:
22.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E

(Escherichia
coli) 		PF01636
(APH) 		12 MET A 103
ILE A 105
ASP A 200
TYR A 202
VAL A 203
ALA A 234
MET A 237
VAL A 238
GLY A 273
THR A 276
PHE A 280
TYR A 289
 ERY  A 402 (-2.2A)
ERY  A 402 ( 4.4A)
ERY  A 402 (-2.4A)
ERY  A 402 (-2.7A)
None
ERY  A 402 ( 3.2A)
ERY  A 402 ( 3.0A)
ERY  A 402 ( 4.7A)
ERY  A 402 ( 3.6A)
ERY  A 402 ( 3.8A)
ERY  A 402 ( 3.6A)
None
 0.48A 5igiA-5igpA:
47.5		 5igiA-5igpA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihs ENDOGLUCANASE,
GLYCOSIDE HYDROLASE
FAMILY 5 PROTEIN

(Cytophaga
hutchinsonii) 		PF00150
(Cellulase) 		5 MET A  91
ASP A 122
GLY A 193
THR A 217
TYR A 221
 None
 1.05A 5igiA-5ihsA:
undetectable		 5igiA-5ihsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv9 LPS-ASSEMBLY
LIPOPROTEIN LPTE
LPS-ASSEMBLY PROTEIN
LPTD

(Klebsiella
pneumoniae) 		PF03968
(OstA)
PF04390
(LptE)
PF04453
(OstA_C) 		5 MET B 147
ILE B 143
ASP A 584
VAL B 122
GLY A 613
 None
 1.25A 5igiA-5iv9B:
undetectable		 5igiA-5iv9B:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvk UNCHARACTERIZED
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 5 MET A 181
VAL A 185
VAL A 241
GLY A 398
TYR A 402
 None
None
None
None
GOL  A 654 (-4.4A)
 1.24A 5igiA-5jvkA:
undetectable		 5igiA-5jvkA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale) 		PF07992
(Pyr_redox_2) 		5 ALA A 142
VAL A  13
GLY A  46
THR A  47
TYR A  92
 None
None
FAD  A 601 (-3.1A)
FAD  A 601 (-3.2A)
None
 1.11A 5igiA-5m10A:
undetectable		 5igiA-5m10A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
PROTEIN TRANSLOCASE
SUBUNIT SECF

(Escherichia
coli) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG)
PF13721
(SecD-TM1) 		5 ILE D 450
ASP F  51
ALA F 201
GLY D 571
THR D 572
 None
 1.12A 5igiA-5mg3D:
0.3		 5igiA-5mg3D:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndl CRH-LIKE PROTEIN

(Aspergillus
fumigatus) 		no annotation 5 ILE A 110
VAL A 120
VAL A 172
PHE A  87
TYR A  43
 None
 1.27A 5igiA-5ndlA:
undetectable		 5igiA-5ndlA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nue MALATE DEHYDROGENASE
1, CYTOPLASMIC

(Arabidopsis
thaliana) 		no annotation 5 ILE A  59
VAL A  54
ALA A  13
VAL A  22
GLY A  78
 None
 1.21A 5igiA-5nueA:
undetectable		 5igiA-5nueA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5j 30S RIBOSOMAL
PROTEIN S2

(Mycolicibacterium
smegmatis) 		PF00318
(Ribosomal_S2) 		5 ILE V 200
VAL V  57
ALA V 160
VAL V  67
GLY V 180
 None
 1.26A 5igiA-5o5jV:
1.4		 5igiA-5o5jV:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE

(Hypericum
androsaemum) 		no annotation 5 ILE A 313
VAL A 383
ALA A 385
VAL A 286
GLY A 372
 None
 1.25A 5igiA-5ucoA:
undetectable		 5igiA-5ucoA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE

(Hypericum
androsaemum) 		no annotation 5 ILE A 313
VAL A 383
MET A 287
VAL A 286
GLY A 372
 None
 1.10A 5igiA-5ucoA:
undetectable		 5igiA-5ucoA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uq6 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5

(Sus scrofa) 		PF00149
(Metallophos) 		5 ILE A 133
VAL A 276
ALA A 274
VAL A 237
GLY A 242
 None
 1.19A 5igiA-5uq6A:
undetectable		 5igiA-5uq6A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2i GLYCOSYLASPARAGINASE

(Elizabethkingia
meningoseptica) 		PF01112
(Asparaginase_2) 		5 VAL A  91
ALA A  67
VAL A  79
GLY A 190
THR A 201
 None
 1.15A 5igiA-5v2iA:
undetectable		 5igiA-5v2iA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmm IRON-REGULATED CELL
WALL-ANCHORED
PROTEIN

(Staphylococcus
aureus) 		no annotation 5 MET H 254
VAL H 234
VAL H 200
THR H 179
PHE H 178
 None
 1.26A 5igiA-5vmmH:
undetectable		 5igiA-5vmmH:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE

(Streptomyces
peucetius) 		no annotation 5 ASP A 302
VAL A 164
ALA A 166
GLY A 146
THR A 145
 None
 1.12A 5igiA-5wgcA:
undetectable		 5igiA-5wgcA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 5 VAL A 264
ALA A  97
VAL A  93
GLY A 655
THR A 659
 None
 1.20A 5igiA-5yj6A:
undetectable		 5igiA-5yj6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ch3 FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Salmonella
enterica) 		no annotation 5 ILE A 420
VAL A 367
MET A 374
VAL A 375
GLY A 435
 None
 1.18A 5igiA-6ch3A:
undetectable		 5igiA-6ch3A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dzs HOMOSERINE
DEHYDROGENASE

(Mycolicibacterium
hassiacum) 		no annotation 5 MET A 318
ILE A  26
ALA A 105
VAL A 103
GLY A  83
 None
None
NAP  A 500 (-3.3A)
None
NAP  A 500 ( 3.2A)
 1.13A 5igiA-6dzsA:
undetectable		 5igiA-6dzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ae7 PHOSPHOLIPASE A2

(Notechis
scutatus) 		PF00068
(Phospholip_A2_1) 		4 HIS A  48
GLU A 101
LEU A  92
TYR A  75
 None
 1.09A 5igiA-1ae7A:
undetectable		 5igiA-1ae7A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		4 PRO A 396
GLU A 568
LEU A 577
TYR A 485
 None
 0.87A 5igiA-1d8cA:
undetectable		 5igiA-1d8cA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9z EXCINUCLEASE UVRABC
COMPONENT UVRB

([Bacillus]
caldotenax) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		4 HIS A 248
GLU A 208
ALA A 129
TYR A  88
 None
 0.96A 5igiA-1d9zA:
undetectable		 5igiA-1d9zA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0c SULFURTRANSFERASE

(Azotobacter
vinelandii) 		PF00581
(Rhodanese) 		4 PRO A   8
GLU A  90
ALA A 198
TYR A 240
 None
 1.08A 5igiA-1e0cA:
undetectable		 5igiA-1e0cA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g3n V-CYCLIN

(Human
gammaherpesvirus
8) 		PF00134
(Cyclin_N)
PF09080
(K-cyclin_vir_C) 		4 PRO C 187
GLU C  91
ALA C  99
LEU C 138
 None
 1.02A 5igiA-1g3nC:
undetectable		 5igiA-1g3nC:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gdh D-GLYCERATE
DEHYDROGENASE

(Hyphomicrobium
methylovorum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 PRO A 230
ALA A 163
LEU A 162
TYR A 153
 None
 1.08A 5igiA-1gdhA:
undetectable		 5igiA-1gdhA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gt9 KUMAMOLYSIN

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		4 PRO 1  54
ALA 1 281
LEU 1 159
TYR 1  98
 None
 1.06A 5igiA-1gt91:
undetectable		 5igiA-1gt91:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		4 PRO A 169
HIS A 124
GLU A  51
ALA A 150
 None
 1.06A 5igiA-1h4lA:
8.1		 5igiA-1h4lA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 PRO A 455
GLU A 542
ALA A 464
LEU A 390
 None
 1.09A 5igiA-1hp1A:
0.0		 5igiA-1hp1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iir GLYCOSYLTRANSFERASE
GTFB

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		4 PRO A 251
ALA A 362
LEU A 363
TYR A 242
 None
 1.09A 5igiA-1iirA:
undetectable		 5igiA-1iirA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		4 HIS A 464
GLU A 474
LEU A 483
TYR A 449
 None
 0.60A 5igiA-1lnsA:
undetectable		 5igiA-1lnsA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mco IGG1 MCG INTACT
ANTIBODY (HEAVY
CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PRO H 229
HIS H 420
LEU H 391
TYR H 358
 GAL  H 435 (-4.8A)
None
None
None
 1.07A 5igiA-1mcoH:
undetectable		 5igiA-1mcoH:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjb L-ALANINE
DEHYDROGENASE

(Phormidium
lapideum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 HIS A 350
GLU A 117
LEU A  89
TYR A 319
 None
 1.06A 5igiA-1pjbA:
undetectable		 5igiA-1pjbA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1

(Mesorhizobium
loti) 		PF00797
(Acetyltransf_2) 		4 PRO A 138
GLU A 186
ALA A  86
LEU A   9
 None
 1.07A 5igiA-2bszA:
undetectable		 5igiA-2bszA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dxa PROTEIN YBAK

(Escherichia
coli) 		PF04073
(tRNA_edit) 		4 HIS A  18
ALA A   4
LEU A 106
TYR A  45
 None
 1.09A 5igiA-2dxaA:
undetectable		 5igiA-2dxaA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF11501
(Nsp1) 		4 GLU A  25
ALA A  31
LEU A  96
TYR A  86
 None
 1.06A 5igiA-2gdtA:
undetectable		 5igiA-2gdtA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E

(Pisum sativum) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		4 HIS A 310
GLU A 304
ALA A 431
LEU A 426
 None
 1.04A 5igiA-2h21A:
undetectable		 5igiA-2h21A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mri 26S PROTEASOME
REGULATORY SUBUNIT
RPN9

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		4 HIS A 235
GLU A 232
LEU A 222
TYR A 228
 None
 1.09A 5igiA-2mriA:
2.7		 5igiA-2mriA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1x 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Deinococcus
radiodurans) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		4 HIS A 117
ALA A  86
LEU A  37
TYR A  67
 None
 1.06A 5igiA-2o1xA:
undetectable		 5igiA-2o1xA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 PRO A 153
GLU A  57
ALA A  65
LEU A 128
 None
 0.98A 5igiA-2p3xA:
undetectable		 5igiA-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pok PEPTIDASE,
M20/M25/M40 FAMILY

(Streptococcus
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 PRO A 406
GLU A  61
ALA A  46
TYR A  66
 None
 1.07A 5igiA-2pokA:
undetectable		 5igiA-2pokA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pok PEPTIDASE,
M20/M25/M40 FAMILY

(Streptococcus
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 PRO A 406
GLU A  61
LEU A  42
TYR A  66
 None
 0.99A 5igiA-2pokA:
undetectable		 5igiA-2pokA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1

(Sulfolobus
solfataricus) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		4 PRO A  30
HIS A  35
GLU A 211
ALA A 242
 None
 1.09A 5igiA-2qbyA:
undetectable		 5igiA-2qbyA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wda PUTATIVE SECRETED
LYASE

(Streptomyces
violaceoruber) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 PRO A 494
ALA A 407
LEU A 400
TYR A 236
 GOL  A1771 (-4.3A)
None
GOL  A1772 (-4.3A)
PEG  A1779 (-4.4A)
 1.10A 5igiA-2wdaA:
undetectable		 5igiA-2wdaA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z00 DIHYDROOROTASE

(Thermus
thermophilus) 		PF01979
(Amidohydro_1) 		4 PRO A 309
ALA A 107
LEU A 115
TYR A  81
 None
 1.05A 5igiA-2z00A:
undetectable		 5igiA-2z00A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 PRO A 340
GLU A 161
ALA A 169
LEU A 329
 None
 1.04A 5igiA-2z7rA:
7.3		 5igiA-2z7rA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqo PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		no annotation 4 PRO A 216
GLU A 240
ALA A 168
LEU A 165
 None
 1.08A 5igiA-3aqoA:
undetectable		 5igiA-3aqoA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 HIS A 471
GLU A 206
ALA A 426
LEU A 429
 None
NDP  A 501 (-3.2A)
None
None
 1.04A 5igiA-3au9A:
undetectable		 5igiA-3au9A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA

(Chlorobaculum
tepidum) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 PRO A  44
GLU A 314
ALA A 330
LEU A 327
 None
 0.96A 5igiA-3cp8A:
undetectable		 5igiA-3cp8A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6k PUTATIVE
AMINOTRANSFERASE

(Corynebacterium
diphtheriae) 		PF12897
(Aminotran_MocR) 		4 HIS A 308
ALA A  85
LEU A  86
TYR A 219
 None
None
None
EDO  A 422 (-4.5A)
 0.98A 5igiA-3d6kA:
undetectable		 5igiA-3d6kA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3del ARGININE BINDING
PROTEIN

(Chlamydia
trachomatis) 		PF00497
(SBP_bac_3) 		4 GLU B  79
ALA B  64
LEU B  63
TYR B  44
 None
 1.04A 5igiA-3delB:
undetectable		 5igiA-3delB:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhu ALPHA-AMYLASE

(Lactobacillus
plantarum) 		PF00128
(Alpha-amylase) 		4 HIS A 332
ALA A 291
LEU A 295
TYR A 308
 None
 1.09A 5igiA-3dhuA:
undetectable		 5igiA-3dhuA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2s PUTATIVE NADH-FLAVIN
REDUCTASE

(Lactobacillus
paracasei) 		PF13460
(NAD_binding_10) 		4 HIS A  88
GLU A  57
ALA A   4
LEU A  28
 None
 0.89A 5igiA-3h2sA:
undetectable		 5igiA-3h2sA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 PRO B 246
ALA B 187
LEU B 205
TYR B 314
 None
 1.07A 5igiA-3hkzB:
undetectable		 5igiA-3hkzB:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 PRO A 274
GLU A 305
ALA A 327
LEU A 184
 None
 1.03A 5igiA-3hztA:
5.2		 5igiA-3hztA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		4 PRO A 211
GLU A 242
ALA A 264
LEU A 120
 None
 1.06A 5igiA-3kl8A:
8.1		 5igiA-3kl8A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 PRO A 196
HIS A 147
GLU A  66
ALA A 173
 None
 0.93A 5igiA-3mi9A:
8.0		 5igiA-3mi9A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mml ALLOPHANATE
HYDROLASE SUBUNIT 1
ALLOPHANATE
HYDROLASE SUBUNIT 2

(Mycolicibacterium
smegmatis) 		PF02626
(CT_A_B)
PF02682
(CT_C_D) 		4 PRO A 245
GLU A 266
ALA A 286
TYR B   9
 None
 1.08A 5igiA-3mmlA:
undetectable		 5igiA-3mmlA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3t PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE

(Thiobacillus
denitrificans) 		PF00563
(EAL) 		4 PRO A 662
GLU A 591
ALA A 598
LEU A 559
 None
 0.79A 5igiA-3n3tA:
undetectable		 5igiA-3n3tA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF02784
(Orn_Arg_deC_N) 		4 HIS A  98
GLU A 143
ALA A 364
LEU A 313
 None
 1.02A 5igiA-3nzqA:
undetectable		 5igiA-3nzqA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of5 DETHIOBIOTIN
SYNTHETASE

(Francisella
tularensis) 		PF13500
(AAA_26) 		4 PRO A  80
HIS A 126
ALA A 135
LEU A 136
 None
 0.98A 5igiA-3of5A:
undetectable		 5igiA-3of5A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 PRO A 265
GLU A 296
ALA A 318
LEU A 175
 None
 1.08A 5igiA-3q5iA:
7.0		 5igiA-3q5iA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qi6 CYSTATHIONINE
GAMMA-SYNTHASE METB
(CGS)

(Mycobacterium
ulcerans) 		PF01053
(Cys_Met_Meta_PP) 		4 PRO A 156
HIS A 265
GLU A 374
ALA A 271
 None
 1.10A 5igiA-3qi6A:
undetectable		 5igiA-3qi6A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thz DNA MISMATCH REPAIR
PROTEIN MSH2

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 GLU A 749
ALA A 309
LEU A 310
TYR A 678
 None
 0.98A 5igiA-3thzA:
2.8		 5igiA-3thzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 PRO A 633
GLU A 453
ALA A 461
LEU A 622
 None
 0.99A 5igiA-3txoA:
8.3		 5igiA-3txoA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uaq LBPB B-LOBE

(Moraxella bovis) 		PF01298
(TbpB_B_D)
PF17484
(TbpB_A) 		4 GLU A 320
ALA A 238
LEU A 253
TYR A 157
 None
 1.09A 5igiA-3uaqA:
undetectable		 5igiA-3uaqA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up4 OTEMO

(Pseudomonas
putida) 		PF00743
(FMO-like) 		4 PRO A 145
HIS A 520
GLU A 526
LEU A 289
 FAD  A 551 ( 4.3A)
None
None
None
 0.99A 5igiA-3up4A:
undetectable		 5igiA-3up4A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 PRO A 293
GLU A  73
ALA A  25
LEU A  66
 None
 1.00A 5igiA-3w15A:
undetectable		 5igiA-3w15A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		4 PRO A 583
HIS A 306
ALA A 238
LEU A 275
 None
 0.96A 5igiA-3wnpA:
undetectable		 5igiA-3wnpA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		4 HIS A1944
GLU A1746
ALA A1847
LEU A1846
 None
 1.10A 5igiA-4asiA:
undetectable		 5igiA-4asiA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		no annotation 4 HIS A 245
ALA A 256
LEU A 270
TYR A 222
 None
 1.08A 5igiA-4czxA:
undetectable		 5igiA-4czxA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5g CYCLOHEXANE-1,2-DION
E HYDROLASE

(Azoarcus sp.
BH72) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 PRO A 296
GLU A 248
ALA A 229
LEU A 228
 None
 0.97A 5igiA-4d5gA:
undetectable		 5igiA-4d5gA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE

(Chromobacterium
violaceum) 		PF01979
(Amidohydro_1) 		4 PRO A 194
HIS A  70
GLU A 320
LEU A 295
 None
 1.00A 5igiA-4f0sA:
undetectable		 5igiA-4f0sA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxq PUTATIVE
ADP-RIBOSYLTRANSFERA
SE CERTHRAX

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox)
PF07737
(ATLF) 		4 GLU A 266
ALA A 327
LEU A 328
TYR A 419
 None
 0.97A 5igiA-4fxqA:
undetectable		 5igiA-4fxqA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpc HEME OXYGENASE

(Corynebacterium
diphtheriae) 		PF01126
(Heme_oxygenase) 		4 HIS A  20
ALA A   9
LEU A 180
TYR A 133
 BLA  A 901 (-3.7A)
None
None
None
 1.09A 5igiA-4gpcA:
undetectable		 5igiA-4gpcA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr5 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
lydicus) 		PF00501
(AMP-binding)
PF03621
(MbtH) 		4 HIS A 128
GLU A 130
ALA A 138
LEU A 110
 None
 1.10A 5igiA-4gr5A:
undetectable		 5igiA-4gr5A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Haemophilus
influenzae) 		PF01546
(Peptidase_M20) 		4 HIS A 257
GLU A 254
ALA A 106
LEU A   8
 None
 1.01A 5igiA-4h2kA:
undetectable		 5igiA-4h2kA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED

(Xanthomonas
oryzae) 		PF01053
(Cys_Met_Meta_PP) 		4 PRO B 158
HIS B 268
GLU B 380
ALA B 274
 None
 1.08A 5igiA-4iyoB:
undetectable		 5igiA-4iyoB:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxr ACETYLTRANSFERASE

(Sinorhizobium
meliloti) 		PF13420
(Acetyltransf_4) 		4 GLU A  93
ALA A   3
LEU A   5
TYR A  68
 None
 1.07A 5igiA-4jxrA:
undetectable		 5igiA-4jxrA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k02 1,4-DIHYDROXY-2-NAPH
THOYL-COA
THIOESTERASE

(Arabidopsis
thaliana) 		PF03061
(4HBT) 		4 PRO A  14
GLU A  95
ALA A  64
LEU A 133
 None
 1.04A 5igiA-4k02A:
undetectable		 5igiA-4k02A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k73 L,D-TRANSPEPTIDASE

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		4 PRO A 125
GLU A 190
ALA A 254
LEU A 249
 None
 1.03A 5igiA-4k73A:
undetectable		 5igiA-4k73A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1

(Rattus
norvegicus) 		PF04495
(GRASP55_65) 		4 HIS A  17
GLU A  33
LEU A 162
TYR A 134
 ZN  A 301 ( 3.4A)
None
None
None
 1.00A 5igiA-4kfvA:
undetectable		 5igiA-4kfvA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdv ANNEXIN

(Schistosoma
mansoni) 		PF00191
(Annexin) 		5 PRO A  21
HIS A 212
GLU A 213
ALA A 219
LEU A 222
 None
 1.37A 5igiA-4mdvA:
undetectable		 5igiA-4mdvA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhp GLUTAMINYL CYCLASE,
PUTATIVE

(Ixodes
scapularis) 		PF04389
(Peptidase_M28) 		4 PRO A 318
HIS A 128
ALA A 150
LEU A  60
 None
 1.02A 5igiA-4mhpA:
undetectable		 5igiA-4mhpA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 PRO A 120
GLU A  80
ALA A 361
LEU A 360
 None
 1.06A 5igiA-4mrmA:
undetectable		 5igiA-4mrmA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4px9 ATP-DEPENDENT RNA
HELICASE DDX3X

(Homo sapiens) 		PF00270
(DEAD) 		4 GLU A 284
ALA A 232
LEU A 236
TYR A 291
 None
 1.07A 5igiA-4px9A:
undetectable		 5igiA-4px9A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnl POSSIBLE GALACTOSE
MUTAROTASE

(Streptomyces
platensis) 		PF01263
(Aldose_epim) 		4 PRO A 310
ALA A 256
LEU A 269
TYR A 181
 None
 1.03A 5igiA-4rnlA:
undetectable		 5igiA-4rnlA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trq NUCLEAR MRNA EXPORT
PROTEIN SAC3
NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF03399
(SAC3_GANP) 		4 PRO B 339
GLU B 387
ALA A 399
LEU A 370
 None
 1.03A 5igiA-4trqB:
undetectable		 5igiA-4trqB:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9c LACTOFERRIN-BINDING
PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17484
(TbpB_A) 		4 GLU A 323
ALA A 234
LEU A 249
TYR A 165
 None
 1.05A 5igiA-4u9cA:
undetectable		 5igiA-4u9cA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whn APXC

(Actinobacillus
pleuropneumoniae) 		PF02794
(HlyC) 		4 PRO A  54
HIS A  24
ALA A  33
LEU A  37
 None
 1.06A 5igiA-4whnA:
undetectable		 5igiA-4whnA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xq7 2'-5'-OLIGOADENYLATE
SYNTHASE-LIKE
PROTEIN

(Homo sapiens) 		PF10421
(OAS1_C) 		4 PRO A 306
GLU A 299
LEU A 267
TYR A 317
 None
 0.97A 5igiA-4xq7A:
undetectable		 5igiA-4xq7A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y67 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE,
APICOPLAST

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 HIS A 471
GLU A 206
ALA A 426
LEU A 429
 None
 1.04A 5igiA-4y67A:
undetectable		 5igiA-4y67A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yac C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		4 PRO A 187
GLU A  28
ALA A   9
LEU A  87
 None
 1.05A 5igiA-4yacA:
undetectable		 5igiA-4yacA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3y BENZOYL-COA
REDUCTASE, PUTATIVE

(Geobacter
metallireducens) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		4 PRO A 486
GLU A 453
ALA A 530
LEU A  33
 None
 0.84A 5igiA-4z3yA:
2.4		 5igiA-4z3yA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 HIS A 921
GLU A 571
ALA A 579
TYR A 564
 None
 0.96A 5igiA-4zdnA:
undetectable		 5igiA-4zdnA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aq1 GLUCOSE-6-PHOSPHATE
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		4 PRO A 378
HIS A 511
GLU A 224
ALA A 502
 None
 1.09A 5igiA-5aq1A:
undetectable		 5igiA-5aq1A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bug PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
3-PHOSPHATASE AND
DUAL-SPECIFICITY
PROTEIN PHOSPHATASE
PTEN

(Homo sapiens) 		PF00782
(DSPc)
PF10409
(PTEN_C2) 		4 PRO A 283
ALA A 151
LEU A 152
TYR A 174
 None
 1.00A 5igiA-5bugA:
undetectable		 5igiA-5bugA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7j ATP-DEPENDENT RNA
HELICASE DDX3X

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLU A 284
ALA A 232
LEU A 236
TYR A 291
 None
AMP  A 801 ( 4.3A)
None
None
 1.03A 5igiA-5e7jA:
undetectable		 5igiA-5e7jA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f05 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF5

(Populus
trichocarpa) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 PRO A  56
HIS A 168
ALA A 203
TYR A  79
 GSH  A 301 ( 4.6A)
None
None
None
 1.00A 5igiA-5f05A:
undetectable		 5igiA-5f05A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fei DISTAL TUBE PROTEIN

(Bacillus virus
phi29) 		PF16838
(Caud_tail_N) 		4 GLU A 110
ALA A  75
LEU A  72
TYR A  62
 None
 1.04A 5igiA-5feiA:
undetectable		 5igiA-5feiA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG

(Caenorhabditis
elegans) 		PF03159
(XRN_N) 		4 GLU A  76
ALA A 174
LEU A 175
TYR A  84
 None
 1.03A 5igiA-5firA:
undetectable		 5igiA-5firA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkq ALYGC MUTANT - R241A

(Paraglaciecola
chathamensis) 		PF14592
(Chondroitinas_B) 		5 PRO A 691
GLU A 611
ALA A 623
LEU A 593
TYR A 607
 None
 1.46A 5igiA-5gkqA:
undetectable		 5igiA-5gkqA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE

(Thermococcus
kodakarensis) 		PF02449
(Glyco_hydro_42) 		4 HIS A 335
ALA A 440
LEU A 504
TYR A 444
 None
 1.06A 5igiA-5gsmA:
undetectable		 5igiA-5gsmA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i0p BETA-LACTAMASE
DOMAIN PROTEIN

(Burkholderia
ambifaria) 		PF00753
(Lactamase_B) 		4 HIS A 347
GLU A 242
ALA A 305
LEU A 327
 None
 1.10A 5igiA-5i0pA:
undetectable		 5igiA-5i0pA:
23.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E

(Escherichia
coli) 		PF01636
(APH) 		6 PRO A 112
HIS A 205
GLU A 222
ALA A 233
LEU A 270
TYR A 277
 ERY  A 402 ( 4.1A)
GDP  A 401 (-4.4A)
ERY  A 402 ( 3.9A)
ERY  A 402 ( 3.9A)
None
ERY  A 402 ( 4.5A)
 0.00A 5igiA-5igpA:
47.5		 5igiA-5igpA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR

(Mus musculus) 		no annotation 4 PRO B 170
GLU B 137
ALA B 221
TYR B 228
 None
 1.06A 5igiA-5lhsB:
undetectable		 5igiA-5lhsB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lva NAD(P)H-FMN
OXIDOREDUCTASE

(Bacillus
subtilis) 		PF02525
(Flavodoxin_2) 		4 GLU A 112
ALA A 107
LEU A  66
TYR A 122
 None
FMN  A 201 (-3.3A)
FMN  A 201 (-4.4A)
None
 0.95A 5igiA-5lvaA:
undetectable		 5igiA-5lvaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6k POLYPHOSPHATE:AMP
PHOSPHOTRANSFERASE

(Meiothermus
ruber) 		no annotation 4 HIS A 124
ALA A  64
LEU A 168
TYR A 225
 None
PO4  A 301 ( 4.8A)
None
None
 0.99A 5igiA-5o6kA:
undetectable		 5igiA-5o6kA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thm ESTERASE-6

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 PRO A 220
HIS A 445
LEU A 327
TYR A 273
 None
7BZ  A 601 (-3.8A)
None
None
 1.10A 5igiA-5thmA:
undetectable		 5igiA-5thmA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Neisseria
gonorrhoeae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 PRO A  80
GLU A 143
ALA A 148
LEU A 323
 None
 0.93A 5igiA-5vmtA:
undetectable		 5igiA-5vmtA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S13,
PUTATIVE

(Trichomonas
vaginalis) 		PF00312
(Ribosomal_S15)
PF08069
(Ribosomal_S13_N) 		4 HIS N  90
GLU N  87
ALA N  81
LEU N  75
 G  2 689 ( 3.5A)
G  2 687 ( 3.9A)
U  2 658 ( 3.7A)
None
 1.02A 5igiA-5xyiN:
2.3		 5igiA-5xyiN:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y10 MEMBRANE
GLYCOPROTEIN
POLYPROTEIN

(SFTS
phlebovirus) 		PF07243
(Phlebovirus_G1) 		4 PRO C 265
HIS C  40
ALA C 101
LEU C  96
 None
NAG  C 402 (-4.6A)
None
None
 1.06A 5igiA-5y10C:
undetectable		 5igiA-5y10C:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpc RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 4 HIS A 222
GLU A 219
LEU A 307
TYR A 211
 None
 1.07A 5igiA-6bpcA:
undetectable		 5igiA-6bpcA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byx SHORT ULVAN LYASE

(Alteromonas sp.
LOR) 		no annotation 4 PRO A 244
HIS A 133
ALA A  54
LEU A 511
 None
 1.05A 5igiA-6byxA:
undetectable		 5igiA-6byxA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c29 PUTATIVE METAL
RESISTANCE PROTEIN

(Proteus
mirabilis) 		no annotation 4 PRO A  56
HIS A  70
ALA A  22
LEU A 127
 None
 1.06A 5igiA-6c29A:
undetectable		 5igiA-6c29A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d04 RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 4 PRO E 411
GLU E 204
LEU E 307
TYR E 211
 None
 0.92A 5igiA-6d04E:
undetectable		 5igiA-6d04E:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epe PROTEASOME (PROSOME,
MACROPAIN) 26S
SUBUNIT, NON-ATPASE,
7 (PREDICTED)

(Rattus
norvegicus) 		no annotation 4 PRO U 134
HIS U  96
GLU U  60
ALA U  55
 None
 1.00A 5igiA-6epeU:
undetectable		 5igiA-6epeU:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 4 HIS A2308
GLU A2357
ALA A2396
LEU A2452
 None
 1.05A 5igiA-6ez8A:
undetectable		 5igiA-6ez8A:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5z 24-STEROL
C-METHYLTRANSFERASE

(Haloferax
volcanii) 		no annotation 4 HIS A 165
ALA A 171
LEU A 123
TYR A 114
 None
 1.04A 5igiA-6f5zA:
undetectable		 5igiA-6f5zA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5z 24-STEROL
C-METHYLTRANSFERASE

(Haloferax
volcanii) 		no annotation 4 HIS A 165
GLU A 144
ALA A 171
TYR A 114
 None
 0.86A 5igiA-6f5zA:
undetectable		 5igiA-6f5zA:
13.67