SIMILAR PATTERNS OF AMINO ACIDS FOR 5IFU_A_GBMA801_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 PHE A 472
TYR A 586
ILE A 466
GLY A 468
ILE A 482
 None
None
None
ALF  A 999 (-2.8A)
None
 1.12A 5ifuA-1br2A:
undetectable		 5ifuA-1br2A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2i PROTEIN (RESTRICTION
ENDONUCLEASE BGLII)

(Bacillus
subtilis) 		PF09195
(Endonuc-BglII) 		5 PHE A 174
LEU A 167
THR A 131
GLY A 133
MET A 135
 None
 1.22A 5ifuA-1d2iA:
undetectable		 5ifuA-1d2iA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II

(Synechocystis
sp. PCC 6803) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 345
THR A  18
ARG A  35
GLY A  37
ILE A  38
 None
 1.13A 5ifuA-1e5mA:
undetectable		 5ifuA-1e5mA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 PHE A 243
LEU A 342
THR A 331
ILE A 260
ILE A 432
 None
 1.07A 5ifuA-1ezvA:
undetectable		 5ifuA-1ezvA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fx2 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.1

(Trypanosoma
brucei) 		PF00211
(Guanylate_cyc) 		5 LEU A 968
THR A 905
ILE A 903
GLY A1024
ILE A1025
 None
 1.23A 5ifuA-1fx2A:
2.1		 5ifuA-1fx2A:
18.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hc7 PROLYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		7 PHE A  14
TYR A  18
ILE A 266
GLY A 267
ILE A 270
MET A 271
TYR A 477
 None
 0.73A 5ifuA-1hc7A:
42.4		 5ifuA-1hc7A:
42.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hc7 PROLYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		6 TYR A  18
ARG A 264
ILE A 266
GLY A 267
ILE A 270
MET A 271
 None
 0.48A 5ifuA-1hc7A:
42.4		 5ifuA-1hc7A:
42.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 LEU A 371
THR A 367
ILE A 418
GLY A 365
ILE A 364
 None
 1.08A 5ifuA-1hp1A:
undetectable		 5ifuA-1hp1A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j7x INTERPHOTORECEPTOR
RETINOID-BINDING
PROTEIN

(Xenopus laevis) 		PF03572
(Peptidase_S41)
PF11918
(Peptidase_S41_N) 		5 PHE A 166
TYR A 200
ILE A 104
GLY A 110
ILE A 138
 None
 1.18A 5ifuA-1j7xA:
undetectable		 5ifuA-1j7xA:
20.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		5 PHE A  20
ARG A 271
ILE A 273
ILE A 277
TYR A 481
 None
5CA  A 512 (-4.4A)
None
None
None
 0.69A 5ifuA-1nj1A:
38.9		 5ifuA-1nj1A:
32.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj8 PROLINE-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09181
(ProRS-C_2) 		6 PHE A   3
TYR A   7
ARG A 255
ILE A 257
ILE A 261
TYR A 455
 None
 0.72A 5ifuA-1nj8A:
37.0		 5ifuA-1nj8A:
35.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		5 TYR A  23
TYR A 336
LEU A 363
ILE A 374
TYR A 313
 None
 1.22A 5ifuA-1oltA:
undetectable		 5ifuA-1oltA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to6 GLYCERATE KINASE

(Neisseria
meningitidis) 		PF02595
(Gly_kinase) 		5 THR A 109
ARG A 110
ILE A 112
GLY A 113
ILE A 116
 None
 0.40A 5ifuA-1to6A:
2.5		 5ifuA-1to6A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u60 PROBABLE GLUTAMINASE
YBAS

(Escherichia
coli) 		PF04960
(Glutaminase) 		5 LEU A   2
THR A  47
ILE A  45
GLY A 275
ILE A 276
 None
 1.23A 5ifuA-1u60A:
undetectable		 5ifuA-1u60A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy9 ALPHA-GALACTOSIDASE

(Thermotoga
maritima) 		PF02065
(Melibiase) 		5 PHE A 143
LEU A 306
GLU A 353
ARG A 349
ILE A 342
 None
 1.15A 5ifuA-1zy9A:
undetectable		 5ifuA-1zy9A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		5 TYR A 240
TYR A 232
LEU A 220
ILE A 157
ILE A 194
 None
 1.20A 5ifuA-2azkA:
undetectable		 5ifuA-2azkA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2c SPERMIDINE SYNTHASE

(Caenorhabditis
elegans) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 PHE A 159
LEU A 175
ILE A 115
GLY A 116
ILE A 114
 None
 1.27A 5ifuA-2b2cA:
undetectable		 5ifuA-2b2cA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb0 IMIDAZOLONEPROPIONAS
E

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		5 LEU A   9
GLU A  63
THR A   7
ILE A  42
GLY A 409
 None
 1.26A 5ifuA-2bb0A:
undetectable		 5ifuA-2bb0A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		5 TYR A 243
LEU A 267
GLY A  94
ILE A 425
TYR A 408
 None
 1.00A 5ifuA-2e0wA:
undetectable		 5ifuA-2e0wA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eh3 TRANSCRIPTIONAL
REGULATOR

(Aquifex
aeolicus) 		PF00440
(TetR_N) 		5 PHE A  39
THR A  57
ARG A  56
ILE A  54
ILE A  50
 None
 1.17A 5ifuA-2eh3A:
undetectable		 5ifuA-2eh3A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima) 		PF01497
(Peripla_BP_2) 		5 LEU A 271
ILE A 205
GLY A 195
ILE A 249
TYR A 212
 None
 1.09A 5ifuA-2etvA:
undetectable		 5ifuA-2etvA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima) 		PF01497
(Peripla_BP_2) 		5 TYR A 193
TYR A 268
LEU A 348
ILE A 249
GLY A 195
 None
 1.22A 5ifuA-2etvA:
undetectable		 5ifuA-2etvA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvm DIHYDROPYRIMIDINASE

(Lachancea
kluyveri) 		PF01979
(Amidohydro_1) 		5 TYR A 328
LEU A 286
ILE A 486
GLY A 485
ILE A 469
 None
 1.20A 5ifuA-2fvmA:
undetectable		 5ifuA-2fvmA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gn1 THREONINE
DEHYDRATASE
CATABOLIC

(Salmonella
enterica) 		PF00291
(PALP) 		5 LEU A 188
ILE A 165
GLY A 166
ILE A 169
MET A 170
 LLP  A  58 ( 4.5A)
None
None
None
None
 1.13A 5ifuA-2gn1A:
undetectable		 5ifuA-2gn1A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hna PROTEIN MIOC

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		5 LEU A  66
THR A  56
ILE A  90
GLY A  89
ILE A  88
 None
 1.04A 5ifuA-2hnaA:
4.9		 5ifuA-2hnaA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o55 PUTATIVE
GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE

(Galdieria
sulphuraria) 		PF03009
(GDPD) 		5 LEU A 100
THR A  44
ARG A  15
ILE A  42
GLY A  16
 None
None
SO4  A   1 (-3.8A)
None
None
 1.02A 5ifuA-2o55A:
undetectable		 5ifuA-2o55A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		5 LEU A  48
ARG A  93
ILE A  59
GLY A  90
ILE A  63
 None
 1.12A 5ifuA-2o5vA:
undetectable		 5ifuA-2o5vA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0s CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4

(Saccharomyces
cerevisiae) 		PF00439
(Bromodomain) 		5 PHE A 310
LEU A 258
GLU A  47
ILE A 289
ILE A 250
 None
 1.19A 5ifuA-2r0sA:
undetectable		 5ifuA-2r0sA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Homo sapiens) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 PHE A 713
LEU A 739
ARG A 660
GLY A 736
ILE A 681
 None
 1.16A 5ifuA-2v9yA:
undetectable		 5ifuA-2v9yA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vcl CYANOBACTERIAL
PHYCOERYTHROBILIN

(Prochlorococcus
phage P-SSM2) 		PF05996
(Fe_bilin_red) 		5 TYR A 178
LEU A  72
THR A  95
ILE A 182
MET A 181
 None
 0.96A 5ifuA-2vclA:
undetectable		 5ifuA-2vclA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF05424
(Duffy_binding)
PF15447
(NTS) 		5 ARG A 206
ILE A 202
GLY A 200
ILE A 199
TYR A 308
 None
 1.27A 5ifuA-2xu0A:
undetectable		 5ifuA-2xu0A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz8 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN LF

(Drosophila
melanogaster) 		no annotation 5 TYR A 299
LEU A 284
THR A 268
ILE A 333
GLY A 334
 None
 1.16A 5ifuA-2xz8A:
undetectable		 5ifuA-2xz8A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding)
PF15447
(NTS) 		5 ARG A 206
ILE A 202
GLY A 200
ILE A 199
TYR A 308
 None
 1.22A 5ifuA-2yk0A:
undetectable		 5ifuA-2yk0A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF01336
(tRNA_anti-codon)
PF08489
(DUF1743) 		5 LEU A 261
GLU A 255
ARG A 270
GLY A 271
ILE A 289
 None
 1.17A 5ifuA-3au7A:
undetectable		 5ifuA-3au7A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Sulfolobus
shibatae) 		PF01070
(FMN_dh) 		5 PHE A  53
LEU A  29
ILE A 276
GLY A 294
MET A  63
 None
 1.11A 5ifuA-3b05A:
undetectable		 5ifuA-3b05A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOA
PMOC

(Methylosinus
trichosporium) 		PF02461
(AMO)
PF04896
(AmoC) 		5 GLU C 127
ILE B 107
GLY B 104
ILE B 103
TYR B  42
 None
 1.27A 5ifuA-3chxC:
undetectable		 5ifuA-3chxC:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		5 GLU A 441
THR A  95
GLY A  52
ILE A  51
TYR A 426
 None
 1.23A 5ifuA-3cp2A:
undetectable		 5ifuA-3cp2A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		5 TYR A  65
TYR A  98
ILE A 121
ILE A 122
TYR A 148
 None
 1.24A 5ifuA-3eafA:
3.0		 5ifuA-3eafA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo7 PUTATIVE
NITROREDUCTASE

(Trichormus
variabilis) 		PF00881
(Nitroreductase) 		5 PHE A 374
TYR A  12
LEU A 270
ILE A 184
ILE A 231
 None
 1.24A 5ifuA-3eo7A:
undetectable		 5ifuA-3eo7A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF03598
(CdhC) 		5 GLU A 702
THR A 703
ILE A 704
GLY A 705
ILE A 711
 None
 1.18A 5ifuA-3gitA:
undetectable		 5ifuA-3gitA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyv SULFIDE-QUINONE
REDUCTASE

(Aquifex
aeolicus) 		PF07992
(Pyr_redox_2) 		5 LEU A 191
THR A 186
GLY A 149
ILE A 148
MET A 249
 None
 1.08A 5ifuA-3hyvA:
2.9		 5ifuA-3hyvA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k50 PUTATIVE S41
PROTEASE

(Bacteroides
fragilis) 		PF03572
(Peptidase_S41) 		5 LEU A 130
THR A 185
ILE A 162
GLY A 183
ILE A 182
 None
 1.21A 5ifuA-3k50A:
undetectable		 5ifuA-3k50A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase)
PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		5 TYR E  90
TYR E 314
LEU E  83
ILE E 191
GLY F  46
 None
 1.24A 5ifuA-3kfuE:
undetectable		 5ifuA-3kfuE:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksy SON OF SEVENLESS
HOMOLOG 1

(Homo sapiens) 		PF00125
(Histone)
PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		5 PHE A 588
LEU A 640
ARG A 688
ILE A 610
TYR A 618
 None
 1.26A 5ifuA-3ksyA:
undetectable		 5ifuA-3ksyA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lev RNA POLYMERASE SIGMA
FACTOR

(Thermus
aquaticus) 		PF04542
(Sigma70_r2) 		5 TYR A 217
LEU A 209
THR A 255
ILE A 258
ILE A 262
 None
 1.06A 5ifuA-3levA:
undetectable		 5ifuA-3levA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lot UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF05853
(BKACE) 		5 LEU A 198
THR A 183
ILE A 180
GLY A 178
ILE A 177
 None
 1.27A 5ifuA-3lotA:
undetectable		 5ifuA-3lotA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1u PUTATIVE
GAMMA-D-GLUTAMYL-L-D
IAMINO ACID
ENDOPEPTIDASE

(Desulfovibrio
vulgaris) 		PF00877
(NLPC_P60)
PF12912
(N_NLPC_P60)
PF12913
(SH3_6)
PF12914
(SH3_7) 		5 TYR A 231
LEU A 246
THR A 261
GLY A 189
ILE A 149
 None
 1.27A 5ifuA-3m1uA:
undetectable		 5ifuA-3m1uA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 THR A 200
ARG A 201
ILE A 203
GLY A 204
ILE A 207
 None
 0.86A 5ifuA-3pkoA:
undetectable		 5ifuA-3pkoA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sk1 EHPR

(Pantoea
agglomerans) 		PF00903
(Glyoxalase) 		5 GLU A  72
ILE A  73
GLY A  74
ILE A  75
MET A  76
 None
 1.25A 5ifuA-3sk1A:
undetectable		 5ifuA-3sk1A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H

(Escherichia
coli) 		PF01795
(Methyltransf_5) 		5 TYR A  85
LEU A 100
GLU A 218
GLY A  77
ILE A  75
 None
None
SAM  A 400 (-3.8A)
None
None
 1.28A 5ifuA-3tkaA:
undetectable		 5ifuA-3tkaA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cok PYRUVATE
DECARBOXYLASE

(Gluconacetobacter
diazotrophicus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 328
ARG A 219
ILE A 220
GLY A 217
MET A 243
 None
 0.90A 5ifuA-4cokA:
2.4		 5ifuA-4cokA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00271
(Helicase_C) 		5 PHE A 546
TYR A 537
LEU A 389
ILE A 451
GLY A 452
 None
 1.23A 5ifuA-4db4A:
undetectable		 5ifuA-4db4A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8e GLUTATHIONE
S-TRANSFERASE

(Bombyx mori) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		5 PHE A 188
TYR A 110
LEU A 114
ILE A 171
TYR A 200
 None
 1.23A 5ifuA-4e8eA:
undetectable		 5ifuA-4e8eA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Burkholderia
vietnamiensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 PHE A 203
LEU A  27
GLU A 358
THR A 343
GLY A 348
 None
 1.16A 5ifuA-4f32A:
undetectable		 5ifuA-4f32A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inj LMO1638 PROTEIN

(Listeria
monocytogenes) 		PF02016
(Peptidase_S66) 		5 LEU A 208
THR A 118
ILE A 305
GLY A 306
ILE A 200
 None
 1.17A 5ifuA-4injA:
3.4		 5ifuA-4injA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Paraburkholderia
phymatum) 		PF04166
(PdxA) 		5 LEU A 154
THR A 132
ILE A 130
GLY A  19
ILE A 127
 None
 1.04A 5ifuA-4jqpA:
2.7		 5ifuA-4jqpA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldc DOUBLE C2-LIKE
DOMAIN-CONTAINING
PROTEIN BETA

(Rattus
norvegicus) 		PF00168
(C2) 		5 LEU A 372
ARG A 394
ILE A 272
GLY A 286
ILE A 287
 None
 1.24A 5ifuA-4ldcA:
undetectable		 5ifuA-4ldcA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9d RIK1-ASSOCIATED
FACTOR 1

(Schizosaccharomyces
pombe) 		no annotation 5 LEU B 354
THR B 368
ILE B 375
GLY B 334
ILE B 335
 None
 1.25A 5ifuA-4o9dB:
undetectable		 5ifuA-4o9dB:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phq HEMOLYSIN E,
CHROMOSOMAL

(Escherichia
coli) 		PF06109
(HlyE) 		5 TYR A 165
LEU A 215
GLU A  53
GLY A 188
ILE A 173
 None
 1.22A 5ifuA-4phqA:
undetectable		 5ifuA-4phqA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s13 FERULIC ACID
DECARBOXYLASE 1

(Saccharomyces
cerevisiae) 		PF01977
(UbiD) 		5 LEU A 314
THR A 155
ARG A 175
GLY A 176
ILE A 184
 None
 1.19A 5ifuA-4s13A:
undetectable		 5ifuA-4s13A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Pseudomonas
aeruginosa) 		PF01425
(Amidase)
PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		5 TYR A 101
TYR A 327
LEU A  94
ILE A 202
GLY B  46
 None
 1.16A 5ifuA-4wj3A:
undetectable		 5ifuA-4wj3A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvm DNA POLYMERASE NU

(Homo sapiens) 		PF00476
(DNA_pol_A) 		5 PHE A 197
TYR A 282
GLU A 286
ILE A 285
GLY A 246
 None
 1.16A 5ifuA-4xvmA:
undetectable		 5ifuA-4xvmA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvm DNA POLYMERASE NU

(Homo sapiens) 		PF00476
(DNA_pol_A) 		5 TYR A 282
GLU A 286
ILE A 285
GLY A 246
TYR A 385
 None
 1.12A 5ifuA-4xvmA:
undetectable		 5ifuA-4xvmA:
20.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ydq PROLINE--TRNA LIGASE

(Plasmodium
falciparum) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		10 PHE A 262
TYR A 266
LEU A 287
THR A 513
ARG A 514
ILE A 516
GLY A 517
ILE A 520
MET A 521
TYR A 746
 None
None
None
None
ANP  A 801 (-3.2A)
None
None
None
None
None
 0.35A 5ifuA-4ydqA:
49.9		 5ifuA-4ydqA:
97.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ydq PROLINE--TRNA LIGASE

(Plasmodium
falciparum) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		7 PHE A 262
TYR A 266
TYR A 285
ARG A 514
GLY A 517
ILE A 520
MET A 521
 None
None
None
ANP  A 801 (-3.2A)
None
None
None
 0.97A 5ifuA-4ydqA:
49.9		 5ifuA-4ydqA:
97.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Homo sapiens) 		PF04389
(Peptidase_M28) 		5 TYR A 141
TYR A  85
THR A 108
ILE A 106
ILE A 123
 None
 1.25A 5ifuA-4yu9A:
undetectable		 5ifuA-4yu9A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 215
GLU A 246
THR A 247
ARG A 245
ILE A 243
 None
 1.13A 5ifuA-5ci7A:
undetectable		 5ifuA-5ci7A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2g BETA-LACTAMASE

(Burkholderia
cenocepacia) 		PF00144
(Beta-lactamase) 		5 PHE A  55
LEU A 352
ILE A  27
GLY A  26
ILE A  25
 None
 0.88A 5ifuA-5e2gA:
undetectable		 5ifuA-5e2gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ern FUSICOCCADIENE
SYNTHASE

(Diaporthe
amygdali) 		PF00348
(polyprenyl_synt) 		5 LEU A  87
THR A 117
ILE A 120
ILE A 143
MET A 140
 None
 1.28A 5ifuA-5ernA:
undetectable		 5ifuA-5ernA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32

(Mycobacterium
marinum) 		PF00501
(AMP-binding) 		5 TYR A 182
LEU A 203
THR A 348
GLY A 427
ILE A 428
 None
 1.10A 5ifuA-5ey9A:
undetectable		 5ifuA-5ey9A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gol CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		no annotation 5 GLU A 109
THR A 110
ILE A 111
GLY A 112
ILE A 118
 None
 1.20A 5ifuA-5golA:
undetectable		 5ifuA-5golA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL

(Homo sapiens) 		PF00180
(Iso_dh) 		5 LEU B 236
GLU B 129
ARG B 160
ILE B 153
ILE B 152
 None
 1.28A 5ifuA-5grhB:
3.1		 5ifuA-5grhB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)

(Malassezia
globosa) 		PF01764
(Lipase_3) 		5 PHE A  43
TYR A  54
ILE A  98
GLY A 169
ILE A 168
 None
 1.22A 5ifuA-5gw8A:
undetectable		 5ifuA-5gw8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1s 50S RIBOSOMAL
PROTEIN L13,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00572
(Ribosomal_L13) 		5 PHE L 188
LEU L 239
THR L 130
ILE L 131
ILE L 200
 None
 1.26A 5ifuA-5h1sL:
undetectable		 5ifuA-5h1sL:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdb MONOCLONAL ANTIBODY
10E5 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 THR E  58
ARG E  50
ILE E  70
GLY E  49
ILE E  48
 None
 1.18A 5ifuA-5hdbE:
undetectable		 5ifuA-5hdbE:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		5 TYR A 289
LEU A 261
ILE A 278
ILE A 285
MET A 286
 None
 1.27A 5ifuA-5hm5A:
undetectable		 5ifuA-5hm5A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A

(Dictyostelium
discoideum;
Homo sapiens) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 PHE A 485
TYR A 599
ILE A 479
GLY A 481
ILE A 495
 None
None
None
AOV  A1500 (-3.0A)
None
 1.18A 5ifuA-5i4eA:
undetectable		 5ifuA-5i4eA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF

(Thermus
thermophilus) 		no annotation 5 LEU F 755
THR F 730
ILE F 644
GLY F 643
ILE F 770
 None
 1.15A 5ifuA-5it5F:
2.1		 5ifuA-5it5F:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqk PEPTIDASE, PUTATIVE

(Plasmodium
falciparum) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 TYR A 151
LEU A 153
GLY A 241
MET A 451
TYR A 271
 None
 1.22A 5ifuA-5jqkA:
undetectable		 5ifuA-5jqkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ku5 SENSOR KINASE CUSS

(Escherichia
coli) 		no annotation 5 LEU A  62
ARG A 108
ILE A  88
ILE A 169
MET A 150
 None
 1.26A 5ifuA-5ku5A:
undetectable		 5ifuA-5ku5A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l20 CLOSTRIPAIN-RELATED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF03415
(Peptidase_C11) 		5 TYR B 239
LEU B 246
ILE B 226
GLY B 227
ILE B 273
 None
 0.84A 5ifuA-5l20B:
undetectable		 5ifuA-5l20B:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5x DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA135

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF06883
(RNA_pol_Rpa2_4) 		5 TYR B 409
LEU B 413
ARG B 134
ILE B 457
GLY B 458
 None
 1.17A 5ifuA-5m5xB:
undetectable		 5ifuA-5m5xB:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01409
(tRNA-synt_2d)
PF03147
(FDX-ACB) 		5 TYR A 382
ARG A 350
ILE A 352
GLY A 353
ILE A 397
 None
 1.01A 5ifuA-5mgvA:
9.2		 5ifuA-5mgvA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlc 50S RIBOSOMAL
PROTEIN L13,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00572
(Ribosomal_L13) 		5 PHE L 188
LEU L 239
THR L 130
ILE L 131
ILE L 200
 None
 1.27A 5ifuA-5mlcL:
undetectable		 5ifuA-5mlcL:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii) 		no annotation 5 TYR A 347
THR A 438
ILE A 441
GLY A 442
ILE A 445
 8BR  A 501 (-4.3A)
8BR  A 501 ( 4.3A)
8BR  A 501 (-3.4A)
8BR  A 501 ( 3.9A)
None
 0.71A 5ifuA-5o0jA:
2.7		 5ifuA-5o0jA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovt BPH

(Thiobacillus
denitrificans) 		no annotation 5 PHE A  62
TYR A 137
THR A 127
ARG A 126
ILE A  77
 None
 1.28A 5ifuA-5ovtA:
undetectable		 5ifuA-5ovtA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sva MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 21
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 7

(Saccharomyces
cerevisiae) 		PF05983
(Med7)
PF11221
(Med21) 		5 LEU U 126
THR W  70
ARG W  71
ILE W  73
ILE W  77
 None
 1.18A 5ifuA-5svaU:
undetectable		 5ifuA-5svaU:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tbd FV FRAGMENT (MAB4D1)
HEAVY CHAIN

(Mus musculus) 		no annotation 5 PHE F 103
THR E  58
ARG E  50
GLY E  49
ILE E  48
 None
 1.14A 5ifuA-5tbdF:
undetectable		 5ifuA-5tbdF:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		5 TYR A 163
LEU A  43
ARG A 577
GLY A 580
ILE A 583
 None
 1.00A 5ifuA-5ubkA:
undetectable		 5ifuA-5ubkA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f DNA REPLICATION
LICENSING FACTOR
MCM7

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 LEU 7 343
ARG 7 242
ILE 7 315
GLY 7 243
ILE 7 244
 None
 1.22A 5ifuA-5v8f7:
undetectable		 5ifuA-5v8f7:
20.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		7 TYR A1028
LEU A1049
THR A1277
ARG A1278
ILE A1280
GLY A1281
TYR A1512
 None
None
None
91Y  A1601 (-3.4A)
None
None
None
 0.44A 5ifuA-5vadA:
44.4		 5ifuA-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		7 TYR A1028
LEU A1049
THR A1277
ILE A1280
GLY A1281
MET A1285
TYR A1512
 None
 0.70A 5ifuA-5vadA:
44.4		 5ifuA-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xii PROLYL-TRNA
SYNTHETASE (PRORS)

(Toxoplasma
gondii) 		no annotation 8 PHE A 342
TYR A 346
THR A 593
ARG A 594
GLY A 597
ILE A 600
MET A 601
TYR A 830
 None
None
None
ANP  A1001 (-3.7A)
None
None
None
None
 0.45A 5ifuA-5xiiA:
47.6		 5ifuA-5xiiA:
53.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xii PROLYL-TRNA
SYNTHETASE (PRORS)

(Toxoplasma
gondii) 		no annotation 7 PHE A 342
TYR A 346
TYR A 365
ARG A 594
ILE A 600
MET A 601
TYR A 830
 None
None
None
ANP  A1001 (-3.7A)
None
None
None
 1.20A 5ifuA-5xiiA:
47.6		 5ifuA-5xiiA:
53.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xil PUTATIVE PROLYL-TRNA
SYNTHETASE

(Leishmania
major) 		no annotation 9 PHE A 263
TYR A 267
THR A 515
ARG A 516
ILE A 518
GLY A 519
ILE A 522
MET A 523
TYR A 756
 ACT  A1003 (-4.3A)
ACT  A1003 (-4.1A)
None
None
None
None
None
ACT  A1003 (-4.3A)
ACT  A1003 (-4.5A)
 0.35A 5ifuA-5xilA:
48.0		 5ifuA-5xilA:
53.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)

(Cryptosporidium
parvum) 		no annotation 10 PHE A 234
TYR A 238
LEU A 259
THR A 485
ARG A 486
ILE A 488
GLY A 489
ILE A 492
MET A 493
TYR A 719
 None
None
None
None
ANP  A 803 (-3.5A)
None
None
None
None
None
 0.70A 5ifuA-5xioA:
45.9		 5ifuA-5xioA:
58.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)

(Cryptosporidium
parvum) 		no annotation 6 PHE A 234
TYR A 238
TYR A 257
ARG A 486
ILE A 492
MET A 493
 None
None
None
ANP  A 803 (-3.5A)
None
None
 1.26A 5ifuA-5xioA:
45.9		 5ifuA-5xioA:
58.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE

(Eimeria tenella) 		no annotation 8 PHE A 262
TYR A 266
THR A 513
ARG A 514
GLY A 517
ILE A 520
MET A 521
TYR A 750
 None
None
None
ANP  A1001 (-3.6A)
None
None
None
None
 0.42A 5ifuA-5xipA:
50.1		 5ifuA-5xipA:
61.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE

(Eimeria tenella) 		no annotation 7 PHE A 262
TYR A 266
TYR A 285
ARG A 514
ILE A 520
MET A 521
TYR A 750
 None
None
None
ANP  A1001 (-3.6A)
None
None
None
 1.10A 5ifuA-5xipA:
50.1		 5ifuA-5xipA:
61.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D

(Pyrococcus
furiosus) 		no annotation 5 LEU I 111
THR H 279
ILE H 283
GLY H 281
ILE H 284
 None
 1.26A 5ifuA-6cfwI:
undetectable		 5ifuA-6cfwI:
11.57