SIMILAR PATTERNS OF AMINO ACIDS FOR 5IEP_A_VDYA201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1as4 ANTICHYMOTRYPSIN

(Homo sapiens) 		PF00079
(Serpin) 		5 ILE A  57
VAL A 161
LEU A 172
ILE A 169
LEU A 303
 None
 1.31A 5iepA-1as4A:
0.6		 5iepA-1as4A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus) 		PF00464
(SHMT) 		5 ILE A 319
VAL A 213
LEU A 207
ILE A 204
LEU A 298
 None
 1.15A 5iepA-1cj0A:
0.5		 5iepA-1cj0A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1

(Homo sapiens) 		PF02263
(GBP)
PF02841
(GBP_C) 		5 PRO A 291
VAL A 316
LEU A 282
ILE A 286
LEU A  13
 None
 1.40A 5iepA-1f5nA:
0.0		 5iepA-1f5nA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gae D-GLYCERALDEHYDE-3-P
HOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ILE O  30
VAL O 321
LEU O 322
ILE O 325
LEU O  44
 None
 1.08A 5iepA-1gaeO:
0.0		 5iepA-1gaeO:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR

(Equus caballus) 		PF00079
(Serpin) 		5 ILE A  57
VAL A 161
LEU A 172
ILE A 169
LEU A 303
 None
 1.44A 5iepA-1hleA:
0.0		 5iepA-1hleA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iu8 PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Pyrococcus
horikoshii) 		PF01470
(Peptidase_C15) 		5 ILE A 112
VAL A 164
LEU A  64
ILE A  22
LEU A 147
 None
 1.48A 5iepA-1iu8A:
undetectable		 5iepA-1iu8A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obb ALPHA-GLUCOSIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 ILE A 345
VAL A  35
LEU A  37
ILE A   8
LEU A 322
 None
 1.04A 5iepA-1obbA:
0.0		 5iepA-1obbA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9w GENERAL SECRETION
PATHWAY PROTEIN E

(Vibrio cholerae) 		PF00437
(T2SSE) 		5 ILE A 259
VAL A 291
LEU A 319
ILE A 322
LEU A 370
 None
 1.46A 5iepA-1p9wA:
0.0		 5iepA-1p9wA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE

(Cryptococcus
neoformans) 		PF00475
(IGPD) 		5 MET A  56
VAL A 154
LEU A 156
ILE A 114
LEU A  43
 None
 1.41A 5iepA-1rhyA:
0.6		 5iepA-1rhyA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rt8 FIMBRIN

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		5 ILE A 475
VAL A 400
LEU A 395
ILE A 404
LEU A 467
 None
 1.12A 5iepA-1rt8A:
undetectable		 5iepA-1rt8A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suu DNA GYRASE SUBUNIT A

(Borreliella
burgdorferi) 		PF03989
(DNA_gyraseA_C) 		5 ILE A 656
VAL A 642
LEU A 568
ILE A 562
TYR A 558
 None
 1.29A 5iepA-1suuA:
undetectable		 5iepA-1suuA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svx ANKYRIN REPEAT
PROTEIN OFF7

(-) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 PRO A  83
MET A  34
VAL A  30
ILE A  62
TYR A  56
 None
 1.16A 5iepA-1svxA:
undetectable		 5iepA-1svxA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvi HYPOTHETICAL UPF0054
PROTEIN TM1509

(Thermotoga
maritima) 		PF02130
(UPF0054) 		5 ILE A  74
VAL A 133
LEU A  21
ILE A  24
LEU A   5
 None
 1.35A 5iepA-1tviA:
undetectable		 5iepA-1tviA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdz METHYLTRANSFERASE
GIDB

(Bacillus
subtilis) 		PF02527
(GidB) 		5 ILE A  59
VAL A  70
LEU A  94
ILE A  73
LEU A  17
 None
 1.12A 5iepA-1xdzA:
undetectable		 5iepA-1xdzA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls ORPHAN NUCLEAR
RECEPTOR NR1I3

(Mus musculus) 		PF00104
(Hormone_recep) 		5 ILE E 332
VAL E 179
LEU E 353
ILE E 356
LEU E 249
 None
None
TCD  E 805 (-4.2A)
None
None
 1.08A 5iepA-1xlsE:
0.7		 5iepA-1xlsE:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 SARCOSINE OXIDASE

(Pyrococcus
horikoshii) 		PF01266
(DAO) 		5 ILE B  20
MET B  64
VAL B  63
TYR B 328
LEU B  24
 None
 1.22A 5iepA-1y56B:
undetectable		 5iepA-1y56B:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE

(Trypanosoma
brucei) 		PF02545
(Maf) 		5 ILE A   9
PRO A  82
VAL A  68
LEU A  69
LEU A 207
 None
 1.49A 5iepA-2amhA:
undetectable		 5iepA-2amhA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1c CARBOXYPEPTIDASE B

(Helicoverpa zea) 		PF00246
(Peptidase_M14) 		5 ILE A  64
VAL A 289
LEU A 271
ILE A  74
LEU A 191
 None
 1.24A 5iepA-2c1cA:
undetectable		 5iepA-2c1cA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1c ISOCITRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		5 ILE A 317
VAL A  24
LEU A  84
ILE A  22
LEU A 321
 None
 1.41A 5iepA-2d1cA:
undetectable		 5iepA-2d1cA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dut HETEROCHROMATIN-ASSO
CIATED PROTEIN MENT

(Gallus gallus) 		PF00079
(Serpin) 		5 ILE A  35
VAL A 164
LEU A 175
ILE A 172
LEU A 316
 None
 1.31A 5iepA-2dutA:
undetectable		 5iepA-2dutA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exa PENICILLIN-BINDING
PROTEIN 4

(Escherichia
coli) 		PF02113
(Peptidase_S13) 		5 PRO A  60
VAL A 346
LEU A 340
ILE A 348
LEU A 303
 None
 1.40A 5iepA-2exaA:
undetectable		 5iepA-2exaA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyn ALPHA-ACTININ 1

(Homo sapiens) 		PF00307
(CH) 		5 ILE A 227
PRO A 233
VAL A 164
ILE A 166
TYR A 241
 None
 1.16A 5iepA-2eynA:
undetectable		 5iepA-2eynA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwn DIHYDROOROTASE

(Porphyromonas
gingivalis) 		PF01979
(Amidohydro_1) 		5 ILE A 237
VAL A 161
LEU A 167
ILE A 170
LEU A 248
 None
 1.33A 5iepA-2gwnA:
undetectable		 5iepA-2gwnA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5t PROTEIN C7ORF24

(Homo sapiens) 		PF13772
(AIG2_2) 		5 ILE A 163
PRO A 165
ILE A 180
TYR A 139
LEU A  51
 None
 1.29A 5iepA-2i5tA:
undetectable		 5iepA-2i5tA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 PRO A 794
MET A 795
LEU A 461
TYR A 443
LEU A 244
 None
 1.44A 5iepA-2ivfA:
undetectable		 5iepA-2ivfA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7c BETA-GLUCOSIDASE A

(Thermotoga
maritima) 		PF00232
(Glyco_hydro_1) 		5 ILE A 331
PRO A 328
VAL A 438
LEU A 444
LEU A 335
 None
 1.50A 5iepA-2j7cA:
undetectable		 5iepA-2j7cA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kvk ACTIN SEVERING AND
DYNAMICS REGULATORY
PROTEIN

(Leishmania
donovani) 		PF00241
(Cofilin_ADF) 		5 ILE A 116
PRO A 115
LEU A  19
ILE A  16
LEU A 124
 None
 1.44A 5iepA-2kvkA:
undetectable		 5iepA-2kvkA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ot3 RAS-RELATED PROTEIN
RAB-21

(Homo sapiens) 		PF00071
(Ras) 		5 MET B 180
VAL B  36
LEU B  24
ILE B  72
TYR B  89
 None
 1.28A 5iepA-2ot3B:
undetectable		 5iepA-2ot3B:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p7k GLYOXALASE FAMILY
PROTEIN

(Listeria
monocytogenes) 		PF00903
(Glyoxalase) 		5 ILE A  25
VAL A  12
LEU A  10
ILE A  56
LEU A 119
 None
 1.41A 5iepA-2p7kA:
undetectable		 5iepA-2p7kA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qde MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Aromatoleum
aromaticum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 243
PRO A 242
VAL A 179
LEU A 212
LEU A 224
 None
 1.25A 5iepA-2qdeA:
undetectable		 5iepA-2qdeA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkd ZINC FINGER PROTEIN
ZPR1

(Mus musculus) 		PF03367
(zf-ZPR1) 		5 ILE A 335
PRO A 336
LEU A 414
ILE A 311
LEU A 391
 None
 1.47A 5iepA-2qkdA:
undetectable		 5iepA-2qkdA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ucz UBIQUITIN
CONJUGATING ENZYME

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		5 ILE A  24
VAL A  88
LEU A  93
ILE A  90
LEU A  16
 None
 1.44A 5iepA-2uczA:
2.4		 5iepA-2uczA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		5 ILE G 241
PRO G 506
VAL G 488
LEU G 370
LEU G 232
 None
 1.41A 5iepA-2uv8G:
undetectable		 5iepA-2uv8G:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		5 PRO A 597
MET A 624
VAL A 639
LEU A1000
LEU A 567
 None
 1.50A 5iepA-2y3aA:
undetectable		 5iepA-2y3aA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 MET A 692
VAL A 695
LEU A 933
ILE A 929
LEU A 734
 None
 1.49A 5iepA-2yd0A:
undetectable		 5iepA-2yd0A:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 ILE A 374
MET A 363
LEU A 492
ILE A 482
LEU A 468
 None
 1.49A 5iepA-2z1aA:
undetectable		 5iepA-2z1aA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glb HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		5 ILE A 109
PRO A 106
LEU A 159
ILE A 269
LEU A  92
 None
None
None
GOL  A   2 (-4.9A)
None
 1.48A 5iepA-3glbA:
undetectable		 5iepA-3glbA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 ILE A 202
PRO A 576
VAL A 260
ILE A 252
LEU A 663
 None
 1.47A 5iepA-3iayA:
undetectable		 5iepA-3iayA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibr BACTERIOPHYTOCHROME

(Pseudomonas
aeruginosa) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 ILE A 195
PRO A 196
VAL A 214
LEU A 251
TYR A 190
 BLA  A 900 (-4.2A)
BLA  A 900 (-4.4A)
None
None
BLA  A 900 (-1.9A)
 1.30A 5iepA-3ibrA:
undetectable		 5iepA-3ibrA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF19
PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV)
no annotation 		5 ILE c 336
PRO A1762
VAL A1688
LEU A1690
ILE A1729
 None
 0.93A 5iepA-3jb9c:
undetectable		 5iepA-3jb9c:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfq TRANSCRIPTION FACTOR
IWS1

(Saccharomyces
cerevisiae) 		PF08711
(Med26) 		5 ILE A  18
MET A  25
VAL A 111
LEU A 109
LEU A  14
 None
 1.10A 5iepA-3nfqA:
undetectable		 5iepA-3nfqA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oak TRANSCRIPTION FACTOR
IWS1

(Saccharomyces
cerevisiae) 		PF08711
(Med26) 		5 ILE A 158
MET A 165
VAL A 251
LEU A 249
LEU A 154
 None
 1.17A 5iepA-3oakA:
undetectable		 5iepA-3oakA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		5 ILE A 102
PRO A 100
LEU A  48
ILE A   5
LEU A 104
 None
 1.16A 5iepA-3olzA:
undetectable		 5iepA-3olzA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pn1 DNA LIGASE

(Haemophilus
influenzae) 		PF01653
(DNA_ligase_aden) 		5 ILE A 258
PRO A 256
VAL A 171
ILE A 252
LEU A 260
 None
 1.32A 5iepA-3pn1A:
undetectable		 5iepA-3pn1A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pn1 DNA LIGASE

(Haemophilus
influenzae) 		PF01653
(DNA_ligase_aden) 		5 PRO A 256
VAL A 171
LEU A 247
ILE A 252
LEU A 260
 None
 1.40A 5iepA-3pn1A:
undetectable		 5iepA-3pn1A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE (INO1)

(Archaeoglobus
fulgidus) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		5 ILE A 207
VAL A 127
LEU A 123
ILE A 171
TYR A 178
 None
 1.45A 5iepA-3qw2A:
undetectable		 5iepA-3qw2A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tex PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF07691
(PA14)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		5 PRO A 407
VAL A 480
LEU A 481
ILE A 484
LEU A 378
 None
 1.29A 5iepA-3texA:
undetectable		 5iepA-3texA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9g ZINC FINGER
CCCH-TYPE ANTIVIRAL
PROTEIN 1

(Rattus
norvegicus) 		no annotation 5 PRO A 143
MET A 194
VAL A 198
LEU A 171
ILE A 173
 None
 1.47A 5iepA-3u9gA:
undetectable		 5iepA-3u9gA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uwd PHOSPHOGLYCERATE
KINASE

(Bacillus
anthracis) 		PF00162
(PGK) 		5 VAL A 334
LEU A 338
ILE A 307
TYR A 345
LEU A 178
 None
 1.32A 5iepA-3uwdA:
undetectable		 5iepA-3uwdA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5i FERROUS IRON
TRANSPORT PROTEIN B

(Gallionella
capsiferriformans) 		PF02421
(FeoB_N) 		5 ILE A  58
PRO A  10
VAL A  36
LEU A  38
LEU A  61
 None
 1.19A 5iepA-3w5iA:
undetectable		 5iepA-3w5iA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		5 MET A 783
VAL A 781
LEU A 779
ILE A 846
LEU A 812
 None
 1.31A 5iepA-3welA:
undetectable		 5iepA-3welA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		5 ILE A 555
PRO A 547
VAL A 478
ILE A 475
LEU A 604
 None
 1.48A 5iepA-3wiqA:
undetectable		 5iepA-3wiqA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq4 RIBONUCLEASE J 1

(Bacillus
subtilis) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		5 ILE A  67
VAL A 421
ILE A 435
TYR A  57
LEU A  70
 None
 1.02A 5iepA-3zq4A:
undetectable		 5iepA-3zq4A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A

(Aspergillus
nidulans) 		PF07745
(Glyco_hydro_53) 		5 ILE A   9
PRO A 298
MET A 315
ILE A 293
LEU A  65
 None
 1.49A 5iepA-4bf7A:
undetectable		 5iepA-4bf7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT

(Salmonella
enterica) 		PF00374
(NiFeSe_Hases) 		5 PRO A 534
VAL A 337
LEU A 339
ILE A 345
LEU A  85
 NFU  A1004 (-3.8A)
None
CL  A1587 ( 4.5A)
None
None
 1.37A 5iepA-4c3oA:
undetectable		 5iepA-4c3oA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
GAMMA

(Methanothermobacter
marburgensis) 		PF00037
(Fer4)
PF01058
(Oxidored_q6) 		5 ILE B 178
PRO B 175
VAL B 257
ILE B 254
LEU B 100
 None
None
None
SF4  B1275 ( 4.6A)
None
 1.46A 5iepA-4ci0B:
undetectable		 5iepA-4ci0B:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3d IMINE REDUCTASE

(Bacillus cereus) 		PF03446
(NAD_binding_2) 		5 PRO A  98
VAL A  82
LEU A  84
ILE A  28
TYR A  93
 None
 1.48A 5iepA-4d3dA:
undetectable		 5iepA-4d3dA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwq TRNA-SPLICING LIGASE
RTCB

(Pyrococcus
horikoshii) 		PF01139
(RtcB) 		5 ILE A 476
PRO A 475
VAL A 303
LEU A 123
TYR A 434
 None
 1.37A 5iepA-4dwqA:
undetectable		 5iepA-4dwqA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4j ARGININE DEIMINASE

(Mycoplasma
penetrans) 		PF02274
(Amidinotransf) 		5 PRO A 148
VAL A 157
LEU A 183
ILE A 185
TYR A  78
 None
 1.36A 5iepA-4e4jA:
undetectable		 5iepA-4e4jA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqn PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF16728
(DUF5066) 		5 ILE C 135
PRO C  49
VAL C  12
LEU C   8
ILE C   9
 None
None
MLY  C  13 ( 3.1A)
None
None
 1.32A 5iepA-4iqnC:
undetectable		 5iepA-4iqnC:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n30 PROTEIN DISULFIDE
ISOMERASE

(Pseudomonas
aeruginosa) 		PF13462
(Thioredoxin_4) 		5 PRO A 184
VAL A  80
LEU A  88
ILE A  58
LEU A  64
 None
 1.21A 5iepA-4n30A:
undetectable		 5iepA-4n30A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8r GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC

(Trypanosoma
brucei) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ILE A  32
VAL A 322
LEU A 323
ILE A 326
LEU A  45
 None
 0.99A 5iepA-4p8rA:
undetectable		 5iepA-4p8rA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 MET B 386
VAL B 376
LEU B 366
ILE B 278
TYR B 252
 None
 1.16A 5iepA-4pe5B:
undetectable		 5iepA-4pe5B:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pht GENERAL SECRETORY
PATHWAY PROTEIN E

(Vibrio
vulnificus) 		PF00437
(T2SSE) 		5 ILE A 255
VAL A 287
LEU A 315
ILE A 318
LEU A 366
 None
 1.48A 5iepA-4phtA:
undetectable		 5iepA-4phtA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1w GLUTAMINE--FRUCTOSE-
6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Staphylococcus
aureus) 		PF01380
(SIS) 		5 ILE A 280
VAL A 319
LEU A 313
ILE A 294
LEU A 278
 None
 1.26A 5iepA-4s1wA:
undetectable		 5iepA-4s1wA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3

(Mus musculus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 ILE A 177
PRO A 174
VAL A 140
ILE A 145
LEU A 204
 None
 1.15A 5iepA-4v2eA:
undetectable		 5iepA-4v2eA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeu TRANSKETOLASE

(Pseudomonas
aeruginosa) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ILE A 428
PRO A 429
MET A 418
LEU A 516
LEU A 332
 None
 1.37A 5iepA-4xeuA:
undetectable		 5iepA-4xeuA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zda ISOCITRATE
DEHYDROGENASE (NADP)
ICD2

(Mycolicibacterium
smegmatis) 		PF03971
(IDH) 		5 PRO A 356
MET A 406
VAL A 535
LEU A 532
LEU A 549
 None
 1.35A 5iepA-4zdaA:
undetectable		 5iepA-4zdaA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		5 ILE A 409
PRO A 411
VAL A 336
ILE A 273
LEU A 650
 None
 1.19A 5iepA-4zhjA:
undetectable		 5iepA-4zhjA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk3 SERPIN B3

(Homo sapiens) 		PF00079
(Serpin) 		5 ILE A  34
VAL A 151
LEU A 162
ILE A 159
LEU A 299
 None
 1.37A 5iepA-4zk3A:
undetectable		 5iepA-4zk3A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ax7 PYRUVYL TRANSFERASE
1

(Schizosaccharomyces
pombe) 		PF04230
(PS_pyruv_trans) 		5 ILE A  90
VAL A 176
ILE A 212
TYR A  83
LEU A 117
 None
 1.32A 5iepA-5ax7A:
undetectable		 5iepA-5ax7A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		5 MET A 266
VAL A 331
LEU A 329
ILE A 214
TYR A 408
 None
 1.43A 5iepA-5cjuA:
undetectable		 5iepA-5cjuA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eog PROTEIN MAB-21-LIKE
1

(Homo sapiens) 		PF03281
(Mab-21) 		5 ILE A 192
PRO A 286
VAL A 203
LEU A 241
TYR A 280
 None
 1.49A 5iepA-5eogA:
undetectable		 5iepA-5eogA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7c ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 ILE A 181
PRO A 180
VAL A 285
LEU A 155
ILE A 163
 None
 1.42A 5iepA-5f7cA:
undetectable		 5iepA-5f7cA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fd4 COMR

(Streptococcus
suis) 		PF13560
(HTH_31) 		5 ILE A 234
PRO A 230
VAL A 169
LEU A 173
LEU A 257
 None
 1.38A 5iepA-5fd4A:
undetectable		 5iepA-5fd4A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		5 ILE A 862
MET A 936
VAL A 888
ILE A 878
LEU A 781
 None
 1.36A 5iepA-5h42A:
undetectable		 5iepA-5h42A:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h76 DARPIN,IMMUNOGLOBULI
N G-BINDING PROTEIN
A

(Staphylococcus
aureus;
synthetic
construct) 		PF02216
(B)
PF12796
(Ank_2) 		5 PRO A  83
MET A  34
VAL A  30
ILE A  62
TYR A  56
 None
 1.12A 5iepA-5h76A:
undetectable		 5iepA-5h76A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hh0 N-ALPHA-ACETYLTRANSF
ERASE 60

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		5 ILE A  36
MET A  66
VAL A  68
ILE A  46
LEU A 171
 None
 0.99A 5iepA-5hh0A:
undetectable		 5iepA-5hh0A:
16.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ieo CDL2.3A

(synthetic
construct) 		PF14534
(DUF4440) 		9 ILE A  37
PRO A  39
MET A  42
MET A  61
VAL A  63
LEU A  88
ILE A 100
TYR A 104
LEU A 118
 VDY  A 206 ( 3.9A)
VDY  A 206 ( 3.5A)
VDY  A 206 ( 3.5A)
VDY  A 206 ( 3.1A)
None
VDY  A 206 (-4.6A)
VDY  A 206 (-2.9A)
VDY  A 206 ( 2.8A)
VDY  A 206 ( 4.4A)
 0.38A 5iepA-5ieoA:
24.9		 5iepA-5ieoA:
94.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5joz NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43B

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		5 ILE A  31
PRO A  30
VAL A 307
LEU A 245
LEU A  50
 None
 1.34A 5iepA-5jozA:
undetectable		 5iepA-5jozA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jri PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Synechocystis
sp. PCC 6803) 		no annotation 5 MET A 253
VAL A 236
LEU A 238
ILE A 223
LEU A 211
 None
 1.48A 5iepA-5jriA:
undetectable		 5iepA-5jriA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3s SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY

(Sulfolobus
acidocaldarius) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 MET B 196
VAL B 193
ILE B 176
TYR B 314
LEU B 334
 None
 1.34A 5iepA-5l3sB:
undetectable		 5iepA-5l3sB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF00499
(Oxidored_q3)
PF06444
(NADH_dehy_S2_C) 		5 ILE N 122
PRO N 123
VAL J 167
ILE J 171
LEU N 131
 None
 1.38A 5iepA-5lc5N:
undetectable		 5iepA-5lc5N:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oik TRANSCRIPTION
ELONGATION FACTOR
SPT4
TRANSCRIPTION
ELONGATION FACTOR
SPT5

(Homo sapiens) 		PF00467
(KOW)
PF03439
(Spt5-NGN)
PF06093
(Spt4) 		5 MET Y  64
VAL Z 182
LEU Z 245
ILE Z 239
LEU Y  10
 None
 0.86A 5iepA-5oikY:
undetectable		 5iepA-5oikY:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oom 39S RIBOSOMAL
PROTEIN L39,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 5 ILE 7 125
PRO 7  88
VAL 7 138
ILE 7 104
TYR 7  99
 None
 1.24A 5iepA-5oom7:
1.5		 5iepA-5oom7:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00849
(PseudoU_synth_2) 		5 PRO A 168
MET A 206
VAL A 187
LEU A 103
LEU A 250
 GOL  A 306 (-3.7A)
None
None
None
None
 1.34A 5iepA-5vbbA:
undetectable		 5iepA-5vbbA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv5 CONSERVED PROTEIN

(Methanosarcina
mazei) 		no annotation 5 ILE A 129
VAL A 155
LEU A 153
ILE A   6
LEU A 127
 None
 1.19A 5iepA-5xv5A:
undetectable		 5iepA-5xv5A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 5 ILE B  84
MET B  17
VAL B  12
LEU B  50
LEU B  33
 None
 1.04A 5iepA-5y58B:
undetectable		 5iepA-5y58B:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 UNCHARACTERIZED
PROTEIN

(Thermobifida
fusca) 		no annotation 5 PRO I 137
MET I  88
VAL I  84
ILE I 196
LEU I 161
 None
 1.26A 5iepA-6c66I:
undetectable		 5iepA-6c66I:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C

(Pyrococcus
furiosus) 		no annotation 5 ILE G  45
VAL D  22
LEU D  23
ILE D  26
TYR G   6
 None
 1.41A 5iepA-6cfwG:
undetectable		 5iepA-6cfwG:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
NADH-PLASTOQUINONE
OXIDOREDUCTASE
SUBUNIT

(Pyrococcus
furiosus) 		no annotation 5 MET M  35
VAL N  10
LEU N   6
ILE M 287
LEU L 115
 None
 1.45A 5iepA-6cfwM:
undetectable		 5iepA-6cfwM:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eq8 PERIPLASMIC
ALPHA-GALACTOSIDE-BI
NDING PROTEIN

(Agrobacterium
tumefaciens) 		no annotation 5 ILE D 408
VAL D 508
LEU D 481
TYR D 365
LEU D 412
 None
 0.86A 5iepA-6eq8D:
undetectable		 5iepA-6eq8D:
18.25