SIMILAR PATTERNS OF AMINO ACIDS FOR 5IEP_A_VDYA201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bgc GRANULOCYTE
COLONY-STIMULATING
FACTOR

(Bos taurus) 		PF16647
(GCSF) 		5 LEU A  83
PHE A 114
LEU A  15
LEU A  10
LEU A  70
 None
 1.22A 5iepA-1bgcA:
undetectable		 5iepA-1bgcA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq3 ENDONUCLEASE

(Pyrococcus
furiosus) 		PF09061
(Stirrup)
PF09062
(Endonuc_subdom)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		5 LEU A 376
TRP A 379
PHE A 108
ALA A 351
LEU A 397
 None
 1.17A 5iepA-1dq3A:
0.3		 5iepA-1dq3A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ek6 UDP-GALACTOSE
4-EPIMERASE

(Homo sapiens) 		PF16363
(GDP_Man_Dehyd) 		5 LEU A  76
PHE A  77
LEU A 127
LEU A 116
ALA A  89
 None
None
None
None
NAI  A 400 (-3.7A)
 0.98A 5iepA-1ek6A:
0.0		 5iepA-1ek6A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hwn EBULIN

(Sambucus ebulus) 		PF00161
(RIP) 		5 LEU A 101
PHE A 102
LEU A 144
PHE A  90
LEU A 119
 None
 1.18A 5iepA-1hwnA:
0.0		 5iepA-1hwnA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l7v VITAMIN B12
TRANSPORT
ATP-BINDING PROTEIN
BTUD

(Escherichia
coli) 		PF00005
(ABC_tran) 		5 LEU C 106
LEU C 176
LEU C 172
ALA C  76
LEU C  78
 None
 1.16A 5iepA-1l7vC:
0.0		 5iepA-1l7vC:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogq POLYGALACTURONASE
INHIBITING PROTEIN

(Phaseolus
vulgaris) 		PF08263
(LRRNT_2) 		5 LEU A 270
LEU A 264
PHE A 217
THR A 223
LEU A 251
 None
 1.10A 5iepA-1ogqA:
0.0		 5iepA-1ogqA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vma CELL DIVISION
PROTEIN FTSY

(Thermotoga
maritima) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 LEU A 244
LEU A 292
THR A  14
ALA A  46
LEU A  43
 None
 1.07A 5iepA-1vmaA:
undetectable		 5iepA-1vmaA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6f ARYLAMINE
N-ACETYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF00797
(Acetyltransf_2) 		5 LEU A  61
LEU A 260
LEU A 257
GLU A  72
LEU A 208
 None
 1.02A 5iepA-1w6fA:
0.0		 5iepA-1w6fA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON

(Salmonella
enterica) 		PF01569
(PAP2) 		5 PHE A  26
LEU A 165
LEU A 107
ALA A 172
LEU A 233
 None
 1.19A 5iepA-2akcA:
0.0		 5iepA-2akcA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bex RIBONUCLEASE
INHIBITOR

(Homo sapiens) 		PF13516
(LRR_6) 		5 LEU A 129
LEU A 148
PHE A 171
ALA A 162
LEU A 189
 None
 1.19A 5iepA-2bexA:
undetectable		 5iepA-2bexA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d42 NON-TOXIC CRYSTAL
PROTEIN

(Bacillus
thuringiensis) 		PF03318
(ETX_MTX2) 		5 LEU A 108
PHE A 164
LEU A 133
THR A 168
ALA A  43
 None
 1.21A 5iepA-2d42A:
0.8		 5iepA-2d42A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e87 HYPOTHETICAL PROTEIN
PH1320

(Pyrococcus
horikoshii) 		PF06858
(NOG1) 		5 LEU A  85
TYR A  78
LEU A 246
LEU A 243
ALA A 195
 None
 1.21A 5iepA-2e87A:
undetectable		 5iepA-2e87A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ei0 1,2-DIHYDROXYNAPHTHA
LENE DIOXYGENASE

(Pseudomonas sp.
C18) 		PF00903
(Glyoxalase) 		5 LEU A 108
PHE A 122
LEU A 150
LEU A  10
LEU A  65
 None
 0.99A 5iepA-2ei0A:
undetectable		 5iepA-2ei0A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Streptococcus
pneumoniae) 		PF01408
(GFO_IDH_MocA) 		5 LEU A  55
PHE A  58
LEU A   4
LEU A  65
ALA A  69
 None
 1.00A 5iepA-2ho5A:
undetectable		 5iepA-2ho5A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ly8 BUDDING YEAST
CHAPERONE SCM3

(Saccharomyces
cerevisiae) 		PF00125
(Histone)
PF15511
(CENP-T_C) 		5 PHE A   7
LEU A  77
LEU A  81
ALA A  41
LEU A 109
 None
 1.23A 5iepA-2ly8A:
undetectable		 5iepA-2ly8A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p17 PIRIN-LIKE PROTEIN

(Geobacillus
kaustophilus) 		PF02678
(Pirin)
PF05726
(Pirin_C) 		5 LEU A 227
LEU A 195
PHE A 191
ALA A 213
LEU A  42
 None
 1.12A 5iepA-2p17A:
undetectable		 5iepA-2p17A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal disease
virus) 		PF04197
(Birna_RdRp) 		5 LEU A 289
LEU A 437
LEU A 225
PHE A 456
ALA A 461
 None
 1.17A 5iepA-2pggA:
undetectable		 5iepA-2pggA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qza SECRETED EFFECTOR
PROTEIN

(Salmonella
enterica) 		PF13599
(Pentapeptide_4)
PF13979
(SopA_C)
PF13981
(SopA) 		5 LEU A 253
PHE A 248
PHE A 233
THR A 261
LEU A 211
 None
 1.02A 5iepA-2qzaA:
undetectable		 5iepA-2qzaA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl3 CATECHOL
2,3-DIOXYGENASE

(Rhodococcus sp.
DK17) 		PF00903
(Glyoxalase) 		5 LEU A 105
PHE A 119
LEU A 147
LEU A   7
LEU A  62
 None
 0.93A 5iepA-2wl3A:
undetectable		 5iepA-2wl3A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE

(Xanthomonas
campestris) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 LEU A  46
LEU A  64
TRP A  60
LEU A  61
ALA A 309
 None
 1.17A 5iepA-2wpgA:
undetectable		 5iepA-2wpgA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro)
PF08369
(PCP_red) 		5 LEU D  90
LEU D 145
PHE D 137
ALA D 203
LEU D 172
 None
 1.02A 5iepA-2ynmD:
undetectable		 5iepA-2ynmD:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro)
PF08369
(PCP_red) 		5 LEU D  90
LEU D 145
PHE D 137
ALA D 203
LEU D 172
 None
 1.07A 5iepA-2ynmD:
undetectable		 5iepA-2ynmD:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF00106
(adh_short) 		5 LEU A  69
LEU A  51
LEU A  60
ALA A   8
LEU A  35
 None
NAP  A 500 (-4.0A)
None
None
None
 1.11A 5iepA-2yutA:
undetectable		 5iepA-2yutA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 PHE A 256
LEU A 273
LEU A 270
PHE A 284
LEU A 335
 None
None
None
PCJ  A   1 (-3.9A)
None
 1.12A 5iepA-2z81A:
undetectable		 5iepA-2z81A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zr1 AGGLUTININ-1 CHAIN A

(Abrus
precatorius) 		PF00161
(RIP) 		5 LEU A  97
PHE A  98
LEU A 140
PHE A  86
LEU A 115
 None
 1.07A 5iepA-2zr1A:
undetectable		 5iepA-2zr1A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afb PUTATIVE CHITINASE

(Pyrococcus
furiosus) 		no annotation 5 LEU A 432
LEU A 466
TRP A 460
ALA A 518
LEU A 521
 None
 1.18A 5iepA-3afbA:
undetectable		 5iepA-3afbA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc8 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Mus musculus) 		PF05889
(SepSecS) 		5 LEU A 377
LEU A 458
PHE A 450
ALA A 436
LEU A 352
 None
 1.15A 5iepA-3bc8A:
undetectable		 5iepA-3bc8A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmn PUTATIVE HYDROLASE

(Chloroflexus
aurantiacus) 		PF10103
(Zincin_2) 		5 LEU A 375
LEU A 343
LEU A 341
PHE A 228
LEU A 172
 None
 0.94A 5iepA-3cmnA:
undetectable		 5iepA-3cmnA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exn PROBABLE
ACETYLTRANSFERASE

(Thermus
thermophilus) 		PF00583
(Acetyltransf_1) 		5 PHE A 135
LEU A  74
PHE A 140
ALA A  86
LEU A 114
 ACO  A1001 (-4.3A)
None
None
None
None
 0.97A 5iepA-3exnA:
undetectable		 5iepA-3exnA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8k PROTEIN
ACETYLTRANSFERASE

(Sulfolobus
solfataricus) 		PF00583
(Acetyltransf_1) 		5 LEU A  21
LEU A  25
PHE A  34
THR A  56
ALA A  69
 None
 1.19A 5iepA-3f8kA:
undetectable		 5iepA-3f8kA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fss HISTONE CHAPERONE
RTT106

(Saccharomyces
cerevisiae) 		PF08512
(Rtt106) 		5 LEU A 174
PHE A 169
LEU A 140
PHE A  93
LEU A 119
 None
 1.20A 5iepA-3fssA:
undetectable		 5iepA-3fssA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fss HISTONE CHAPERONE
RTT106

(Saccharomyces
cerevisiae) 		PF08512
(Rtt106) 		5 PHE A 169
LEU A 140
PHE A  93
ALA A 193
LEU A 119
 None
 1.08A 5iepA-3fssA:
undetectable		 5iepA-3fssA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gn6 CT0912, ORFAN
PROTEIN WITH A
FERREDOXIN-LIKE
DOMAIN REPEAT

(Chlorobaculum
tepidum) 		no annotation 5 LEU A  77
PHE A 132
PHE A 136
ALA A 159
LEU A 144
 None
 1.21A 5iepA-3gn6A:
undetectable		 5iepA-3gn6A:
17.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hx8 PUTATIVE KETOSTEROID
ISOMERASE

(Mesorhizobium
loti) 		PF14534
(DUF4440) 		5 PHE A  36
TYR A  52
LEU A  75
TRP A  76
PHE A 107
 IMD  A   4 (-3.6A)
None
None
UNL  A 200 (-4.9A)
UNL  A 200 (-3.6A)
 0.87A 5iepA-3hx8A:
20.8		 5iepA-3hx8A:
85.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 21

(Homo sapiens) 		PF00443
(UCH) 		5 PHE A 287
LEU A 306
PHE A 283
PHE A 262
LEU A 236
 None
 1.21A 5iepA-3i3tA:
undetectable		 5iepA-3i3tA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcl SPIKE GLYCOPROTEIN

(Murine
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		5 LEU A 790
LEU A 804
PHE A 778
ALA A1053
LEU A1012
 None
 1.22A 5iepA-3jclA:
undetectable		 5iepA-3jclA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		5 PHE A 386
LEU A 360
LEU A 353
PHE A 427
THR A 419
 None
 1.15A 5iepA-3l44A:
undetectable		 5iepA-3l44A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7i TEICHOIC ACID
BIOSYNTHESIS PROTEIN
F

(Staphylococcus
epidermidis) 		PF04464
(Glyphos_transf) 		5 LEU A 429
TYR A 439
LEU A 482
PHE A 472
LEU A 451
 None
 1.19A 5iepA-3l7iA:
undetectable		 5iepA-3l7iA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m19 VARIABLE LYMPHOCYTE
RECEPTOR A DIVERSITY
REGION

(Petromyzon
marinus) 		PF13855
(LRR_8) 		5 LEU A 129
LEU A  94
PHE A 102
PHE A  78
LEU A  49
 None
 1.22A 5iepA-3m19A:
undetectable		 5iepA-3m19A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		5 LEU A 346
PHE A 352
LEU A 394
THR A 183
LEU A 387
 None
 1.19A 5iepA-3mcaA:
undetectable		 5iepA-3mcaA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkh NITROALKANE OXIDASE

(Podospora
anserina) 		PF00441
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 353
TYR A 345
PHE A 270
ALA A 266
LEU A 132
 None
 1.22A 5iepA-3mkhA:
undetectable		 5iepA-3mkhA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpx FYVE, RHOGEF AND PH
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		5 TYR A 907
LEU A 914
LEU A 949
PHE A 997
LEU A1001
 UNX  A   7 ( 4.9A)
None
None
None
None
 1.11A 5iepA-3mpxA:
undetectable		 5iepA-3mpxA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfz ASPARTOACYLASE-2

(Mus musculus) 		PF04952
(AstE_AspA) 		5 PHE A 134
LEU A 142
LEU A 126
PHE A 111
LEU A 115
 None
 1.21A 5iepA-3nfzA:
undetectable		 5iepA-3nfzA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nu8 AMINOTRANSFERASE
WBPE

(Pseudomonas
aeruginosa) 		PF01041
(DegT_DnrJ_EryC1) 		5 LEU A 242
PHE A 245
PHE A  47
THR A 179
LEU A 173
 None
 0.90A 5iepA-3nu8A:
undetectable		 5iepA-3nu8A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojl CAP5O

(Staphylococcus
aureus) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 LEU A 379
PHE A 376
LEU A 312
THR A 308
ALA A 360
 None
 1.19A 5iepA-3ojlA:
0.7		 5iepA-3ojlA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pwz SHIKIMATE
DEHYDROGENASE 3

(Pseudomonas
putida) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 LEU A 205
LEU A 147
LEU A 118
ALA A 188
LEU A 106
 None
 1.13A 5iepA-3pwzA:
undetectable		 5iepA-3pwzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3h HMW1C-LIKE
GLYCOSYLTRANSFERASE

(Actinobacillus
pleuropneumoniae) 		no annotation 5 PHE A  64
LEU A  32
LEU A  28
PHE A 102
LEU A 144
 None
 1.19A 5iepA-3q3hA:
undetectable		 5iepA-3q3hA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qmj ENOYL-COA HYDRATASE,
ECHA8_6

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 LEU A 175
LEU A  90
LEU A  97
PHE A  58
LEU A  16
 None
 1.15A 5iepA-3qmjA:
undetectable		 5iepA-3qmjA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd5 MYPAA.01249.C

(Mycobacterium
avium) 		PF00106
(adh_short) 		5 LEU A 124
LEU A  88
PHE A 173
THR A 285
LEU A  69
 None
 1.06A 5iepA-3rd5A:
undetectable		 5iepA-3rd5A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3re2 PREDICTED PROTEIN

(Nematostella
vectensis) 		PF05053
(Menin) 		5 PHE A  63
LEU A 117
LEU A 121
ALA A 141
LEU A  74
 None
 1.07A 5iepA-3re2A:
undetectable		 5iepA-3re2A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5w L-ORNITHINE
5-MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF13434
(K_oxygenase) 		5 LEU A  44
LEU A 367
LEU A 364
THR A 161
ALA A 163
 None
 1.20A 5iepA-3s5wA:
undetectable		 5iepA-3s5wA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		5 LEU A 758
LEU A 730
LEU A 714
PHE A 751
ALA A 664
 None
 1.15A 5iepA-3sfzA:
undetectable		 5iepA-3sfzA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tg9 PENICILLIN-BINDING
PROTEIN

(Bacillus
halodurans) 		PF00144
(Beta-lactamase) 		5 PHE A 155
TYR A 269
LEU A 256
PHE A  58
LEU A 238
 None
 1.15A 5iepA-3tg9A:
undetectable		 5iepA-3tg9A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amm DYNE8

(Micromonospora
chersina) 		PF00698
(Acyl_transf_1) 		5 PHE A 873
LEU A 510
LEU A 513
ALA A 531
LEU A 543
 None
 1.18A 5iepA-4ammA:
undetectable		 5iepA-4ammA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arc LEUCINE--TRNA LIGASE

(Escherichia
coli) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		5 LEU A 644
PHE A 669
LEU A 736
LEU A 676
LEU A 776
 None
 1.21A 5iepA-4arcA:
undetectable		 5iepA-4arcA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg2 PATF

(Prochloron
didemni) 		no annotation 5 PHE A  85
PHE A 104
PHE A 107
ALA A 110
LEU A 150
 None
 1.20A 5iepA-4bg2A:
undetectable		 5iepA-4bg2A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxx TRANSCRIPTION FACTOR
BYE1

(Saccharomyces
cerevisiae) 		PF07500
(TFIIS_M) 		5 PHE X 278
LEU X 330
LEU X 335
PHE X 249
LEU X 319
 None
 0.90A 5iepA-4bxxX:
undetectable		 5iepA-4bxxX:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		5 LEU A 152
PHE A 143
PHE A 148
ALA A  59
LEU A  63
 None
 1.11A 5iepA-4e1eA:
0.6		 5iepA-4e1eA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE

(Burkholderia
pseudomallei) 		PF00155
(Aminotran_1_2) 		5 PHE A 342
LEU A 327
LEU A 331
ALA A 371
LEU A 363
 None
 1.19A 5iepA-4effA:
undetectable		 5iepA-4effA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9u CG32412

(Drosophila
melanogaster) 		PF04389
(Peptidase_M28) 		5 LEU A 278
LEU A 287
LEU A 217
THR A 234
LEU A 109
 GOL  A 405 (-4.8A)
None
None
GOL  A 405 ( 4.1A)
None
 1.09A 5iepA-4f9uA:
undetectable		 5iepA-4f9uA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbm CURM
SULFOTRANSFERASE

(Moorea
producens) 		PF13469
(Sulfotransfer_3) 		5 LEU A 236
PHE A 235
LEU A 205
LEU A 208
PHE A  33
 None
 1.22A 5iepA-4gbmA:
undetectable		 5iepA-4gbmA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixo NIFS-LIKE PROTEIN

(Rickettsia
africae) 		PF00266
(Aminotran_5) 		5 LEU A 302
PHE A 305
TYR A 367
LEU A 269
LEU A 265
 None
 1.23A 5iepA-4ixoA:
undetectable		 5iepA-4ixoA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz0 CURL

(Moorea
producens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A 884
TYR A 629
LEU A 624
ALA A 609
LEU A 695
 None
 1.05A 5iepA-4mz0A:
undetectable		 5iepA-4mz0A:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 LEU A 401
PHE A 417
PHE A 361
ALA A 350
LEU A 330
 None
 1.08A 5iepA-4nenA:
undetectable		 5iepA-4nenA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz0 GENOME POLYPROTEIN

(Cardiovirus A) 		PF00680
(RdRP_1) 		5 LEU A 251
PHE A 255
TYR A  75
LEU A 206
LEU A  83
 None
 1.21A 5iepA-4nz0A:
undetectable		 5iepA-4nz0A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN

(Streptomyces
pristinaespiralis) 		no annotation 5 LEU A 102
TRP A  77
LEU A 129
PHE A 153
ALA A 183
 None
 1.22A 5iepA-4okmA:
undetectable		 5iepA-4okmA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbv NT-3 GROWTH FACTOR
RECEPTOR

(Gallus gallus) 		PF00047
(ig)
PF13855
(LRR_8)
PF16920
(TPKR_C2) 		5 LEU A 152
LEU A 115
LEU A 139
PHE A 147
ALA A 122
 None
 1.02A 5iepA-4pbvA:
undetectable		 5iepA-4pbvA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pq8 DESIGNED PROTEIN
OR465

(synthetic
construct) 		PF00560
(LRR_1)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 LEU A 187
LEU A 152
PHE A 160
PHE A 136
LEU A 107
 None
 1.22A 5iepA-4pq8A:
undetectable		 5iepA-4pq8A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi7 CELLOBIOSE
DEHYDROGENASE

(Neurospora
crassa) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		5 LEU A 125
LEU A 153
LEU A  70
PHE A 127
LEU A  36
 None
 1.21A 5iepA-4qi7A:
undetectable		 5iepA-4qi7A:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqm URACIL-DNA
GLYCOSYLASE

(Deinococcus
radiodurans) 		PF03167
(UDG) 		5 LEU A  43
LEU A  67
LEU A  23
PHE A  40
ALA A 166
 None
 1.17A 5iepA-4uqmA:
undetectable		 5iepA-4uqmA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yl6 MALCAVERNIN

(Homo sapiens) 		PF16545
(CCM2_C) 		5 LEU A 369
PHE A 368
LEU A 321
LEU A 341
LEU A 306
 None
 1.13A 5iepA-4yl6A:
undetectable		 5iepA-4yl6A:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0k LABDANE-RELATED
DITERPENE SYNTHASE

(Streptomyces
sp.) 		no annotation 5 LEU A 132
PHE A 139
THR A 192
ALA A 196
LEU A 200
 None
 1.16A 5iepA-5a0kA:
undetectable		 5iepA-5a0kA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3k UNCHARACTERIZED
PROTEIN PA3435

(Pseudomonas
aeruginosa) 		PF00258
(Flavodoxin_1) 		5 LEU A  78
LEU A  63
LEU A  67
PHE A 111
GLU A 113
 None
 1.23A 5iepA-5b3kA:
undetectable		 5iepA-5b3kA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2

(Mus musculus) 		PF00617
(RasGEF)
PF00618
(RasGEF_N) 		5 PHE A 174
LEU A 121
TRP A 166
LEU A 133
LEU A 105
 None
 1.16A 5iepA-5cm9A:
undetectable		 5iepA-5cm9A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE

(Escherichia
coli) 		PF02574
(S-methyl_trans) 		5 LEU A 203
LEU A 248
PHE A 195
PHE A 193
ALA A 180
 None
 0.97A 5iepA-5dmnA:
undetectable		 5iepA-5dmnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhx INTERLEUKIN-4

(Homo sapiens) 		PF00727
(IL4) 		5 LEU A  14
PHE A 112
THR A  44
ALA A  48
LEU A  52
 None
 1.07A 5iepA-5fhxA:
undetectable		 5iepA-5fhxA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwj DNA TOPOISOMERASE
2-BETA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		5 LEU A 653
LEU A 475
PHE A 585
THR A 472
LEU A 532
 None
 1.18A 5iepA-5gwjA:
undetectable		 5iepA-5gwjA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxd PROTEIN MPAA

(Escherichia
coli) 		PF00246
(Peptidase_M14) 		5 PHE A 179
LEU A 231
PHE A 211
ALA A  46
LEU A  77
 None
 1.23A 5iepA-5hxdA:
undetectable		 5iepA-5hxdA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA

(Human
coronavirus
HKU1;
Human
immunodeficiency
virus 1) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		5 LEU A 829
LEU A 843
PHE A 817
ALA A1084
LEU A1043
 None
 1.16A 5iepA-5i08A:
undetectable		 5iepA-5i08A:
7.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ieo CDL2.3A

(synthetic
construct) 		PF14534
(DUF4440) 		11 LEU A  12
PHE A  15
TYR A  31
LEU A  54
TRP A  55
LEU A  58
PHE A  68
PHE A  86
GLU A 106
THR A 121
ALA A 123
 VDY  A 206 ( 4.3A)
VDY  A 206 (-3.5A)
None
VDY  A 206 ( 3.9A)
VDY  A 206 ( 4.4A)
VDY  A 206 ( 4.7A)
VDY  A 206 (-3.1A)
VDY  A 206 ( 3.0A)
VDY  A 206 (-2.4A)
VDY  A 206 (-3.4A)
VDY  A 206 ( 3.1A)
 0.12A 5iepA-5ieoA:
24.9		 5iepA-5ieoA:
94.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd9 SPORE COAT PROTEIN H

(Bacillus cereus) 		PF08757
(CotH) 		5 PHE A 299
TYR A 342
PHE A  93
PHE A  94
THR A 250
 None
 1.17A 5iepA-5jd9A:
undetectable		 5iepA-5jd9A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkn PROTEIN FAM63A

(Homo sapiens) 		PF04424
(MINDY_DUB) 		5 PHE A 364
LEU A 332
GLU A 308
ALA A 306
LEU A 302
 None
 0.94A 5iepA-5jknA:
undetectable		 5iepA-5jknA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE SOPA

(Salmonella
enterica) 		PF13599
(Pentapeptide_4)
PF13981
(SopA) 		5 LEU A 253
PHE A 248
PHE A 233
THR A 261
LEU A 211
 None
 1.15A 5iepA-5jw7A:
undetectable		 5iepA-5jw7A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5a PARB DOMAIN PROTEIN
NUCLEASE

(Sulfolobus
solfataricus) 		PF02195
(ParBc) 		5 LEU B 207
LEU B 219
PHE B 117
ALA B 121
LEU B 178
 None
 1.06A 5iepA-5k5aB:
undetectable		 5iepA-5k5aB:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans) 		no annotation 5 PHE B 541
TRP B 661
LEU B 669
GLU B 503
ALA B 505
 None
 1.17A 5iepA-5khnB:
undetectable		 5iepA-5khnB:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis) 		PF00291
(PALP) 		5 LEU B 285
LEU B 165
PHE B 278
PHE B 279
ALA B 191
 None
 1.13A 5iepA-5kzmB:
undetectable		 5iepA-5kzmB:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa) 		PF00305
(Lipoxygenase) 		5 PHE A 455
LEU A 544
PHE A 531
ALA A 391
LEU A 396
 None
 1.11A 5iepA-5lc8A:
undetectable		 5iepA-5lc8A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of2 SPORE
COAT-ASSOCIATED
PROTEIN N

(Bacillus
subtilis) 		no annotation 5 LEU A  46
LEU A 113
PHE A  72
PHE A  70
ALA A  53
 None
 1.23A 5iepA-5of2A:
undetectable		 5iepA-5of2A:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqp CONDENSIN COMPLEX
SUBUNIT 3

(Saccharomyces
cerevisiae) 		no annotation 5 PHE A 268
TRP A 303
PHE A 276
ALA A 329
LEU A 284
 None
 1.23A 5iepA-5oqpA:
undetectable		 5iepA-5oqpA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF04598
(Gasdermin)
PF13416
(SBP_bac_8) 		5 LEU A1355
LEU A1399
THR A 366
ALA A 370
LEU A1392
 None
 1.22A 5iepA-5tj2A:
undetectable		 5iepA-5tj2A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uff RBC36

(Petromyzon
marinus) 		no annotation 5 LEU A 143
LEU A 109
PHE A 117
PHE A  93
LEU A  64
 None
 1.17A 5iepA-5uffA:
undetectable		 5iepA-5uffA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whs CATALASE-PEROXIDASE

(Neurospora
crassa) 		no annotation 5 PHE A 722
LEU A 632
PHE A 659
PHE A 700
LEU A 611
 None
 1.21A 5iepA-5whsA:
undetectable		 5iepA-5whsA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrr PSEUDOKINASE FAM20A

(Homo sapiens) 		PF06702
(Fam20C) 		5 LEU A 340
PHE A 236
THR A 193
ALA A 196
LEU A 301
 None
 1.06A 5iepA-5wrrA:
undetectable		 5iepA-5wrrA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x06 DNAA REGULATORY
INACTIVATOR HDA

(Escherichia
coli) 		no annotation 5 LEU E  48
LEU E  30
PHE E  19
GLU E  17
LEU E  38
 None
None
None
ADP  E1001 (-3.9A)
None
 1.20A 5iepA-5x06E:
undetectable		 5iepA-5x06E:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xev XAA-PRO
DIPEPTIDASE,PEPTIDAS
E-RELATED PROTEIN

(Deinococcus
radiodurans) 		no annotation 5 LEU A 393
LEU A 382
GLU A 278
ALA A 280
LEU A 336
 None
 1.19A 5iepA-5xevA:
undetectable		 5iepA-5xevA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis) 		no annotation 5 LEU A 769
LEU A 766
PHE A 490
PHE A 488
LEU A 781
 None
 1.21A 5iepA-5xwyA:
undetectable		 5iepA-5xwyA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3j TOLL-LIKE RECEPTOR 9

(Equus caballus) 		no annotation 5 LEU A 333
LEU A 296
PHE A 304
PHE A 280
LEU A 235
 None
 1.22A 5iepA-5y3jA:
undetectable		 5iepA-5y3jA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axf RAS GUANYL-RELEASING
PROTEIN 2

(Homo sapiens) 		no annotation 5 LEU A 368
TRP A 206
LEU A 364
PHE A 227
ALA A 245
 None
 1.06A 5iepA-6axfA:
undetectable		 5iepA-6axfA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axg RAS GUANYL-RELEASING
PROTEIN 4

(Homo sapiens) 		no annotation 5 LEU A 413
TRP A 253
LEU A 409
PHE A 274
ALA A 292
 None
 1.09A 5iepA-6axgA:
undetectable		 5iepA-6axgA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfp UBIQUITIN-LIKE
PROTEIN
SMT3,POLYMERASE
ACIDIC PROTEIN

(Influenza A
virus;
Saccharomyces
cerevisiae) 		no annotation 5 LEU A 543
LEU A 482
LEU A 345
PHE A 525
LEU A 500
 None
None
EZS  A 801 (-3.6A)
None
None
 1.23A 5iepA-6cfpA:
undetectable		 5iepA-6cfpA:
19.85