SIMILAR PATTERNS OF AMINO ACIDS FOR 5IEO_A_VDYA206_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1db3 GDP-MANNOSE
4,6-DEHYDRATASE


(Escherichia
coli)
PF16363
(GDP_Man_Dehyd)
5 PHE A 275
LEU A 215
LEU A 217
PHE A 261
ALA A 265
None
1.37A 5ieoA-1db3A:
0.0
5ieoA-1db3A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE


(Bacillus sp.
1011)
PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C)
5 LEU A 606
PHE A 652
PHE A 650
PHE A 670
ALA A 678
None
1.27A 5ieoA-1dedA:
2.7
5ieoA-1dedA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ek6 UDP-GALACTOSE
4-EPIMERASE


(Homo sapiens)
PF16363
(GDP_Man_Dehyd)
5 LEU A  76
PHE A  77
LEU A 127
LEU A 116
ALA A  89
None
None
None
None
NAI  A 400 (-3.7A)
0.97A 5ieoA-1ek6A:
0.0
5ieoA-1ek6A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus)
PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim)
5 LEU B 484
LEU B 452
LEU B 267
PHE B 481
GLU B 255
None
1.33A 5ieoA-1gl9B:
2.9
5ieoA-1gl9B:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gwc GLUTATHIONE
S-TRANSFERASE TSI-1


(Aegilops
tauschii)
PF00043
(GST_C)
PF02798
(GST_N)
5 LEU A  73
LEU A  87
PHE A 199
THR A  19
ALA A 208
None
1.27A 5ieoA-1gwcA:
0.0
5ieoA-1gwcA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imv PIGMENT
EPITHELIUM-DERIVED
FACTOR


(Homo sapiens)
PF00079
(Serpin)
5 LEU A 370
TRP A 197
LEU A 248
PHE A 256
PHE A 376
None
1.37A 5ieoA-1imvA:
undetectable
5ieoA-1imvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itu RENAL DIPEPTIDASE

(Homo sapiens)
PF01244
(Peptidase_M19)
5 LEU A 148
LEU A 187
PHE A 179
THR A 156
ALA A 159
None
1.32A 5ieoA-1ituA:
0.0
5ieoA-1ituA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1e MYCOLIC ACID
SYNTHASE


(Mycobacterium
tuberculosis)
PF02353
(CMAS)
5 PHE A 191
LEU A 236
LEU A 266
PHE A 200
THR A 278
None
1.33A 5ieoA-1l1eA:
0.0
5ieoA-1l1eA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5a AMIDE SYNTHASE

(Vibrio cholerae)
PF00668
(Condensation)
5 PHE A 397
LEU A 404
LEU A 219
PHE A 366
ALA A 237
None
1.30A 5ieoA-1l5aA:
0.8
5ieoA-1l5aA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7s CATALASE

(Pseudomonas
syringae)
PF00199
(Catalase)
PF06628
(Catalase-rel)
5 LEU A 464
TYR A 486
PHE A 185
PHE A 188
ALA A 194
None
1.35A 5ieoA-1m7sA:
undetectable
5ieoA-1m7sA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE


(Bos taurus)
PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C)
5 LEU A 454
PHE A 519
LEU A 527
LEU A 524
PHE A 516
None
1.32A 5ieoA-1n5xA:
undetectable
5ieoA-1n5xA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6y HYPOTHETICAL PROTEIN
YFDW


(Escherichia
coli)
PF02515
(CoA_transf_3)
5 PHE A 378
LEU A 179
LEU A 183
PHE A 381
ALA A  29
None
1.35A 5ieoA-1q6yA:
undetectable
5ieoA-1q6yA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE


(Streptococcus
pneumoniae)
PF00275
(EPSP_synthase)
5 LEU A 276
LEU A 240
GLU A 280
THR A 279
ALA A 288
None
1.28A 5ieoA-1rf5A:
undetectable
5ieoA-1rf5A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ud9 DNA POLYMERASE
SLIDING CLAMP A


(Sulfurisphaera
tokodaii)
PF00705
(PCNA_N)
PF02747
(PCNA_C)
5 LEU A  36
LEU A  78
PHE A  27
PHE A  67
THR A  71
None
1.36A 5ieoA-1ud9A:
undetectable
5ieoA-1ud9A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ued P450 MONOOXYGENASE

(Amycolatopsis
orientalis)
PF00067
(p450)
5 PHE A 175
LEU A 219
LEU A 207
PHE A 199
ALA A 241
None
None
None
None
PG4  A4502 (-4.3A)
1.24A 5ieoA-1uedA:
undetectable
5ieoA-1uedA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl0 HYPOTHETICAL PROTEIN
PA5198


(Pseudomonas
aeruginosa)
PF02016
(Peptidase_S66)
5 LEU A 262
PHE A 266
LEU A 233
LEU A 214
PHE A 250
None
1.34A 5ieoA-1zl0A:
undetectable
5ieoA-1zl0A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN


(Thermus
thermophilus)
PF01409
(tRNA-synt_2d)
5 LEU A 161
LEU A 301
PHE A 131
GLU A 128
ALA A 136
None
1.28A 5ieoA-2amcA:
undetectable
5ieoA-2amcA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9b FUSION GLYCOPROTEIN
F0


(Mammalian
rubulavirus 5)
PF00523
(Fusion_gly)
5 LEU A  79
TYR A 199
LEU A 228
LEU A 224
PHE A 207
None
1.29A 5ieoA-2b9bA:
undetectable
5ieoA-2b9bA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2


(Homo sapiens)
PF01189
(Methyltr_RsmB-F)
5 LEU A 287
PHE A 286
LEU A 354
LEU A 351
ALA A 373
None
1.24A 5ieoA-2b9eA:
undetectable
5ieoA-2b9eA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbz VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR


(Molluscum
contagiosum
virus)
PF01335
(DED)
5 LEU A  73
LEU A  46
LEU A  13
PHE A  77
ALA A  59
None
1.32A 5ieoA-2bbzA:
undetectable
5ieoA-2bbzA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzu FIBER PROTEIN 2

(Human
mastadenovirus
F)
PF00541
(Adeno_knob)
5 PHE A 374
LEU A 252
LEU A 286
PHE A 349
ALA A 379
None
1.26A 5ieoA-2bzuA:
undetectable
5ieoA-2bzuA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d42 NON-TOXIC CRYSTAL
PROTEIN


(Bacillus
thuringiensis)
PF03318
(ETX_MTX2)
5 LEU A 108
PHE A 164
LEU A 133
THR A 168
ALA A  43
None
1.19A 5ieoA-2d42A:
undetectable
5ieoA-2d42A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e87 HYPOTHETICAL PROTEIN
PH1320


(Pyrococcus
horikoshii)
PF06858
(NOG1)
5 LEU A  85
TYR A  78
LEU A 246
LEU A 243
ALA A 195
None
1.22A 5ieoA-2e87A:
undetectable
5ieoA-2e87A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fef HYPOTHETICAL PROTEIN
PA2201


(Pseudomonas
aeruginosa)
PF08929
(DUF1911)
5 LEU A  49
PHE A  52
LEU A 117
TRP A  76
LEU A   8
None
1.36A 5ieoA-2fefA:
undetectable
5ieoA-2fefA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hne L-FUCONATE
DEHYDRATASE


(Xanthomonas
campestris)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 LEU A 153
PHE A 150
LEU A 166
LEU A 144
ALA A 342
None
1.27A 5ieoA-2hneA:
undetectable
5ieoA-2hneA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY


(Streptococcus
pneumoniae)
PF01408
(GFO_IDH_MocA)
5 LEU A  55
PHE A  58
LEU A   4
LEU A  65
ALA A  69
None
0.96A 5ieoA-2ho5A:
undetectable
5ieoA-2ho5A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2khq INTEGRASE

(Staphylococcus
saprophyticus)
PF14659
(Phage_int_SAM_3)
5 LEU A  44
PHE A   4
LEU A  71
LEU A  56
PHE A  79
None
1.38A 5ieoA-2khqA:
undetectable
5ieoA-2khqA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlv XISI PROTEIN-LIKE

(Trichormus
variabilis)
PF08869
(XisI)
5 LEU A  14
PHE A  61
LEU A  97
LEU A  95
THR A  75
None
1.24A 5ieoA-2nlvA:
undetectable
5ieoA-2nlvA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8r POLYPHOSPHATE KINASE

(Porphyromonas
gingivalis)
PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C)
5 LEU A  47
LEU A 661
PHE A  50
THR A  88
ALA A  84
None
1.27A 5ieoA-2o8rA:
undetectable
5ieoA-2o8rA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens)
PF00067
(p450)
5 LEU A 370
PHE A 118
LEU A 241
LEU A 296
THR A 212
HEM  A 500 ( 3.8A)
None
None
None
None
1.34A 5ieoA-2pg6A:
undetectable
5ieoA-2pg6A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2r GLUCOKINASE 1,
PUTATIVE


(Trypanosoma
cruzi)
PF02685
(Glucokinase)
5 LEU A 120
PHE A 121
PHE A  69
PHE A  68
ALA A  35
None
1.37A 5ieoA-2q2rA:
undetectable
5ieoA-2q2rA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyt 2-DEHYDROPANTOATE
2-REDUCTASE


(Porphyromonas
gingivalis)
PF02558
(ApbA)
PF08546
(ApbA_C)
5 LEU A  24
LEU A  85
PHE A 160
THR A 179
ALA A 175
None
1.34A 5ieoA-2qytA:
undetectable
5ieoA-2qytA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r09 CYTOHESIN-3

(Mus musculus)
PF00169
(PH)
PF01369
(Sec7)
5 LEU A 105
LEU A 158
LEU A 153
PHE A 134
ALA A 171
None
1.31A 5ieoA-2r09A:
undetectable
5ieoA-2r09A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjb UNCHARACTERIZED
PROTEIN


(Shigella
flexneri)
PF07063
(DUF1338)
5 LEU A 261
TYR A 433
LEU A 119
PHE A 388
ALA A 110
None
1.31A 5ieoA-2rjbA:
undetectable
5ieoA-2rjbA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE


(Xanthomonas
campestris)
PF00128
(Alpha-amylase)
PF11941
(DUF3459)
5 LEU A  46
LEU A  64
TRP A  60
LEU A  61
ALA A 309
None
1.20A 5ieoA-2wpgA:
undetectable
5ieoA-2wpgA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8t TAKEOUT-LIKE PROTEIN
1


(Epiphyas
postvittana)
PF06585
(JHBP)
5 LEU A  51
LEU A 116
PHE A  49
PHE A  47
ALA A 196
None
1.30A 5ieoA-3e8tA:
3.0
5ieoA-3e8tA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8k PROTEIN
ACETYLTRANSFERASE


(Sulfolobus
solfataricus)
PF00583
(Acetyltransf_1)
5 LEU A  21
LEU A  25
PHE A  34
THR A  56
ALA A  69
None
1.22A 5ieoA-3f8kA:
undetectable
5ieoA-3f8kA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flo DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
DNA POLYMERASE ALPHA
SUBUNIT B


(Saccharomyces
cerevisiae)
PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N)
PF08996
(zf-DNA_Pol)
5 LEU A 410
LEU B1324
LEU A 448
PHE A 403
ALA A 491
None
1.38A 5ieoA-3floA:
undetectable
5ieoA-3floA:
15.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hx8 PUTATIVE KETOSTEROID
ISOMERASE


(Mesorhizobium
loti)
PF14534
(DUF4440)
5 PHE A  36
TYR A  52
LEU A  75
TRP A  76
PHE A 107
IMD  A   4 (-3.6A)
None
None
UNL  A 200 (-4.9A)
UNL  A 200 (-3.6A)
0.87A 5ieoA-3hx8A:
20.1
5ieoA-3hx8A:
82.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3


(Homo sapiens)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
5 LEU A 595
LEU A 577
LEU A 585
PHE A 681
ALA A 619
None
1.39A 5ieoA-3ihyA:
undetectable
5ieoA-3ihyA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksx NITRATE TRANSPORT
PROTEIN


(Xanthomonas
citri)
PF09084
(NMT1)
5 LEU A 299
PHE A 294
LEU A 209
LEU A 207
ALA A 183
None
1.32A 5ieoA-3ksxA:
undetectable
5ieoA-3ksxA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1


(Bacillus
anthracis)
PF00202
(Aminotran_3)
5 PHE A 386
LEU A 360
LEU A 353
PHE A 427
THR A 419
None
1.15A 5ieoA-3l44A:
undetectable
5ieoA-3l44A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n90 THYLAKOID LUMENAL 15
KDA PROTEIN 1,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF00805
(Pentapeptide)
5 LEU A 202
LEU A 138
LEU A 143
PHE A 189
THR A 177
None
1.17A 5ieoA-3n90A:
undetectable
5ieoA-3n90A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojl CAP5O

(Staphylococcus
aureus)
PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N)
5 LEU A 379
PHE A 376
LEU A 312
THR A 308
ALA A 360
None
1.21A 5ieoA-3ojlA:
undetectable
5ieoA-3ojlA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE


(Methanocaldococcus
jannaschii)
no annotation 5 PHE A  58
LEU A 215
LEU A 212
THR A  99
ALA A  96
None
1.37A 5ieoA-3s4lA:
undetectable
5ieoA-3s4lA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc)
5 LEU A 929
PHE A 958
PHE A 746
PHE A 815
ALA A 792
None
1.22A 5ieoA-3s5kA:
undetectable
5ieoA-3s5kA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5w L-ORNITHINE
5-MONOOXYGENASE


(Pseudomonas
aeruginosa)
PF13434
(K_oxygenase)
5 LEU A  44
LEU A 367
LEU A 364
THR A 161
ALA A 163
None
1.20A 5ieoA-3s5wA:
undetectable
5ieoA-3s5wA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1


(Mus musculus)
PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40)
5 LEU A 758
LEU A 730
LEU A 714
PHE A 751
ALA A 664
None
1.11A 5ieoA-3sfzA:
2.6
5ieoA-3sfzA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsy SORTILIN-RELATED
RECEPTOR


(Homo sapiens)
PF15901
(Sortilin_C)
PF15902
(Sortilin-Vps10)
5 LEU A 503
LEU A 475
TRP A 530
LEU A 477
ALA A 533
None
1.34A 5ieoA-3wsyA:
undetectable
5ieoA-3wsyA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE


(Thermotoga
maritima)
PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
5 PHE A 249
LEU A 103
LEU A 287
PHE A 242
ALA A 267
None
1.30A 5ieoA-3zl8A:
undetectable
5ieoA-3zl8A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2


(Homo sapiens)
PF01233
(NMT)
PF02799
(NMT_C)
5 LEU A 462
PHE A 461
LEU A 398
PHE A 467
ALA A 419
None
1.24A 5ieoA-4c2xA:
undetectable
5ieoA-4c2xA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp2 EPITHELIAL ADHESIN 9

([Candida]
glabrata)
PF10528
(GLEYA)
5 LEU A 238
PHE A 191
LEU A 283
PHE A 201
ALA A 208
None
1.37A 5ieoA-4cp2A:
undetectable
5ieoA-4cp2A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE


(Escherichia
coli)
PF00378
(ECH_1)
5 LEU A 127
LEU A  31
TRP A  85
LEU A  88
ALA A  60
None
1.35A 5ieoA-4fzwA:
undetectable
5ieoA-4fzwA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbm CURM
SULFOTRANSFERASE


(Moorea
producens)
PF13469
(Sulfotransfer_3)
5 LEU A 236
PHE A 235
LEU A 205
LEU A 208
PHE A  33
None
1.19A 5ieoA-4gbmA:
undetectable
5ieoA-4gbmA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gip FUSION GLYCOPROTEIN
F1
FUSION GLYCOPROTEIN
F2


(Mammalian
rubulavirus 5)
PF00523
(Fusion_gly)
5 LEU A  79
TYR D 199
LEU D 228
LEU D 224
PHE D 207
None
1.27A 5ieoA-4gipA:
undetectable
5ieoA-4gipA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7n ALDEHYDE
DEHYDROGENASE


(Trichormus
variabilis)
PF00171
(Aldedh)
5 LEU A  89
LEU A 179
TRP A  56
LEU A 183
PHE A  88
None
1.36A 5ieoA-4h7nA:
undetectable
5ieoA-4h7nA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igb LPXTG CELL WALL
SURFACE PROTEIN


(Streptococcus
gordonii)
no annotation 5 LEU D 283
LEU D 285
PHE D 306
GLU D 169
ALA D 304
None
None
None
SO4  D 501 ( 4.2A)
NA  D 504 ( 4.5A)
1.21A 5ieoA-4igbD:
1.5
5ieoA-4igbD:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irl MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NOVEL PROTEIN
SIMILAR TO
VERTEBRATE GUANYLATE
BINDING PROTEIN
FAMILY


(Danio rerio;
Escherichia
coli)
PF00619
(CARD)
PF13416
(SBP_bac_8)
5 LEU A 431
PHE A 442
LEU A 453
LEU A 457
PHE A 428
None
1.22A 5ieoA-4irlA:
undetectable
5ieoA-4irlA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixo NIFS-LIKE PROTEIN

(Rickettsia
africae)
PF00266
(Aminotran_5)
5 LEU A 302
PHE A 305
TYR A 367
LEU A 269
LEU A 265
None
1.24A 5ieoA-4ixoA:
undetectable
5ieoA-4ixoA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8s CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1


(Homo sapiens)
PF16417
(CNOT1_TTP_bind)
5 LEU A 885
PHE A 886
LEU A 925
LEU A 921
ALA A 947
None
1.36A 5ieoA-4j8sA:
undetectable
5ieoA-4j8sA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kd6 ENOYL-COA
HYDRATASE/ISOMERASE


(Paraburkholderia
graminis)
PF00378
(ECH_1)
5 LEU A 176
LEU A  92
LEU A  99
PHE A  61
ALA A 111
None
1.35A 5ieoA-4kd6A:
undetectable
5ieoA-4kd6A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1


(Oncorhynchus
mykiss)
PF00079
(Serpin)
5 LEU A 107
LEU A  55
LEU A  59
PHE A 111
ALA A 335
None
1.37A 5ieoA-4kdsA:
undetectable
5ieoA-4kdsA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf6 GLYCOLIPID TRANSFER
PROTEIN
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF08718
(GLTP)
5 PHE A 171
LEU A  43
LEU A 118
PHE A 162
ALA A 161
None
1.26A 5ieoA-4kf6A:
undetectable
5ieoA-4kf6A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9m RAS GUANYL-RELEASING
PROTEIN 1


(Homo sapiens)
PF00130
(C1_1)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF13405
(EF-hand_6)
5 LEU A 417
TRP A 257
LEU A 413
PHE A 278
ALA A 296
None
1.29A 5ieoA-4l9mA:
undetectable
5ieoA-4l9mA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maa PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN


(Pseudomonas
protegens)
PF13458
(Peripla_BP_6)
5 LEU A 110
LEU A 205
PHE A 178
GLU A 131
ALA A 181
None
None
GOL  A 503 ( 4.0A)
None
None
1.35A 5ieoA-4maaA:
undetectable
5ieoA-4maaA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT


(Bos taurus)
PF00027
(cNMP_binding)
5 LEU A 327
LEU A 257
LEU A 254
PHE A 290
ALA A 268
None
1.35A 5ieoA-4mx3A:
undetectable
5ieoA-4mx3A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz0 GENOME POLYPROTEIN

(Cardiovirus A)
PF00680
(RdRP_1)
6 LEU A 251
PHE A 255
TYR A  75
LEU A 206
LEU A  83
PHE A 256
None
1.41A 5ieoA-4nz0A:
undetectable
5ieoA-4nz0A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqr CYP105AS1

(Amycolatopsis
orientalis)
PF00067
(p450)
5 LEU A 372
LEU A 328
LEU A 330
PHE A 366
PHE A 362
None
1.31A 5ieoA-4oqrA:
undetectable
5ieoA-4oqrA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqs CYP105AS1

(Amycolatopsis
orientalis)
PF00067
(p450)
5 LEU A 372
LEU A 328
LEU A 330
PHE A 366
PHE A 362
None
1.28A 5ieoA-4oqsA:
undetectable
5ieoA-4oqsA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B


(Drosophila
melanogaster)
PF00079
(Serpin)
5 LEU A  13
PHE A  16
LEU A 281
LEU A  24
ALA A 332
None
1.11A 5ieoA-4p0fA:
undetectable
5ieoA-4p0fA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B


(Drosophila
melanogaster)
PF00079
(Serpin)
5 LEU A 112
PHE A 116
LEU A  65
LEU A  63
ALA A  51
None
1.39A 5ieoA-4p0fA:
undetectable
5ieoA-4p0fA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbv NT-3 GROWTH FACTOR
RECEPTOR


(Gallus gallus)
PF00047
(ig)
PF13855
(LRR_8)
PF16920
(TPKR_C2)
5 LEU A 152
LEU A 115
LEU A 139
PHE A 147
ALA A 122
None
1.00A 5ieoA-4pbvA:
undetectable
5ieoA-4pbvA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pht GENERAL SECRETORY
PATHWAY PROTEIN E


(Vibrio
vulnificus)
PF00437
(T2SSE)
5 PHE A  69
LEU A  37
LEU A  26
PHE A  18
ALA A  47
None
1.31A 5ieoA-4phtA:
undetectable
5ieoA-4phtA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqm URACIL-DNA
GLYCOSYLASE


(Deinococcus
radiodurans)
PF03167
(UDG)
5 LEU A  43
LEU A  67
LEU A  23
PHE A  40
ALA A 166
None
1.16A 5ieoA-4uqmA:
undetectable
5ieoA-4uqmA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqm URACIL-DNA
GLYCOSYLASE


(Deinococcus
radiodurans)
PF03167
(UDG)
5 LEU A  43
LEU A  67
LEU A  23
PHE A  40
THR A 164
None
1.35A 5ieoA-4uqmA:
undetectable
5ieoA-4uqmA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvq THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE


(Prochloron sp.)
no annotation 5 PHE A1149
LEU A1078
PHE A1162
THR A1108
ALA A1111
None
1.11A 5ieoA-4uvqA:
2.8
5ieoA-4uvqA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3k UNCHARACTERIZED
PROTEIN PA3435


(Pseudomonas
aeruginosa)
PF00258
(Flavodoxin_1)
5 LEU A  78
LEU A  63
LEU A  67
PHE A 111
GLU A 113
None
1.22A 5ieoA-5b3kA:
undetectable
5ieoA-5b3kA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST


(Pseudomonas
aeruginosa)
no annotation 5 PHE A 157
LEU A 171
TRP A 170
LEU A 209
THR A 277
None
1.33A 5ieoA-5b7iA:
undetectable
5ieoA-5b7iA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT


(Influenza C
virus)
PF00602
(Flu_PB1)
PF00603
(Flu_PA)
5 LEU B 238
LEU A 671
LEU A 670
PHE A 642
ALA A 688
None
1.34A 5ieoA-5d9aB:
undetectable
5ieoA-5d9aB:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE


(Escherichia
coli)
PF02574
(S-methyl_trans)
5 LEU A 203
LEU A 248
PHE A 195
PHE A 193
ALA A 180
None
0.96A 5ieoA-5dmnA:
undetectable
5ieoA-5dmnA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo6 COPROPORPHYRINOGEN
OXIDASE


(Acinetobacter
baumannii)
PF01218
(Coprogen_oxidas)
5 LEU A  58
LEU A 223
LEU A 219
PHE A  40
GLU A  31
None
1.29A 5ieoA-5eo6A:
1.4
5ieoA-5eo6A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1


(Pectobacterium
atrosepticum)
PF01867
(Cas_Cas1)
5 TYR A  23
LEU A 298
LEU A 233
PHE A  93
THR A  63
None
1.38A 5ieoA-5fclA:
undetectable
5ieoA-5fclA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foz LARVICIDAL TOXIN
PROTEIN


(Lysinibacillus
sphaericus)
PF05431
(Toxin_10)
5 LEU B 406
PHE B 423
PHE B 429
GLU B 287
ALA B 364
None
1.37A 5ieoA-5fozB:
2.8
5ieoA-5fozB:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hra ASPARTATE/GLUTAMATE
RACEMASE


(Escherichia
coli)
PF01177
(Asp_Glu_race)
5 TYR A  18
LEU A  81
LEU A  64
PHE A  45
THR A 198
None
None
None
None
DAS  A 301 (-3.2A)
1.35A 5ieoA-5hraA:
undetectable
5ieoA-5hraA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvn 3-DEHYDROQUINATE
SYNTHASE


(Francisella
tularensis)
PF01761
(DHQ_synthase)
5 LEU A 334
PHE A 332
LEU A 320
LEU A 316
PHE A 278
None
1.38A 5ieoA-5hvnA:
undetectable
5ieoA-5hvnA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5h INNER MEMBRANE
PROTEIN YEJM


(Escherichia
coli)
PF00884
(Sulfatase)
PF11893
(DUF3413)
5 LEU A 358
LEU A 494
LEU A 498
PHE A 362
THR A 266
None
1.34A 5ieoA-5i5hA:
undetectable
5ieoA-5i5hA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd9 SPORE COAT PROTEIN H

(Bacillus cereus)
PF08757
(CotH)
5 PHE A 299
TYR A 342
PHE A  93
PHE A  94
THR A 250
None
1.17A 5ieoA-5jd9A:
undetectable
5ieoA-5jd9A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans)
no annotation 5 PHE B 541
TRP B 661
LEU B 669
GLU B 503
ALA B 505
None
1.14A 5ieoA-5khnB:
undetectable
5ieoA-5khnB:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m45 ACETONE CARBOXYLASE
BETA SUBUNIT


(Xanthobacter
autotrophicus)
PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N)
5 PHE B 503
TYR B 295
LEU B 300
LEU B 711
PHE B  34
None
1.31A 5ieoA-5m45B:
undetectable
5ieoA-5m45B:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5o RNASE ADAPTER
PROTEIN RAPZ


(Escherichia
coli)
PF03668
(ATP_bind_2)
5 LEU A 261
PHE A 265
LEU A 233
LEU A 160
PHE A 164
None
1.26A 5ieoA-5o5oA:
undetectable
5ieoA-5o5oA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5s RNASE ADAPTER
PROTEIN RAPZ


(Escherichia
coli)
PF03668
(ATP_bind_2)
5 LEU A 261
PHE A 265
LEU A 233
LEU A 160
PHE A 164
None
1.32A 5ieoA-5o5sA:
undetectable
5ieoA-5o5sA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of2 SPORE
COAT-ASSOCIATED
PROTEIN N


(Bacillus
subtilis)
no annotation 5 LEU A  46
LEU A 113
PHE A  72
PHE A  70
ALA A  53
None
1.24A 5ieoA-5of2A:
undetectable
5ieoA-5of2A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uto EDD DOMAIN PROTEIN,
DEGV FAMILY


(Staphylococcus
aureus)
no annotation 5 LEU A 168
PHE A 263
GLU A  40
THR A  10
ALA A 122
None
PLM  A 301 ( 4.8A)
None
None
PLM  A 301 ( 4.5A)
1.23A 5ieoA-5utoA:
undetectable
5ieoA-5utoA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36


(Bos taurus)
no annotation 5 LEU A 807
PHE A 812
LEU A 955
LEU A 982
ALA A 839
None
1.25A 5ieoA-5vhaA:
undetectable
5ieoA-5vhaA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxg -

(-)
no annotation 5 LEU A  36
PHE A 126
LEU A 171
LEU A 165
PHE A 110
None
1.28A 5ieoA-5xxgA:
undetectable
5ieoA-5xxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1


(Saccharomyces
cerevisiae)
no annotation 5 LEU A  38
PHE A 129
LEU A 115
LEU A 111
PHE A  82
None
1.28A 5ieoA-5y58A:
2.2
5ieoA-5y58A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axf RAS GUANYL-RELEASING
PROTEIN 2


(Homo sapiens)
no annotation 5 LEU A 368
TRP A 206
LEU A 364
PHE A 227
ALA A 245
None
1.05A 5ieoA-6axfA:
undetectable
5ieoA-6axfA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axg RAS GUANYL-RELEASING
PROTEIN 4


(Homo sapiens)
no annotation 5 LEU A 413
TRP A 253
LEU A 409
PHE A 274
ALA A 292
None
1.06A 5ieoA-6axgA:
undetectable
5ieoA-6axgA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6


(Homo sapiens;
Mus musculus)
no annotation 5 LEU A 105
LEU A 158
LEU A 153
PHE A 134
ALA A 171
None
1.31A 5ieoA-6bbpA:
undetectable
5ieoA-6bbpA:
23.02