SIMILAR PATTERNS OF AMINO ACIDS FOR 5IEO_A_VDYA206_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1db3 | GDP-MANNOSE4,6-DEHYDRATASE (Escherichiacoli) |
PF16363(GDP_Man_Dehyd) | 5 | PHE A 275LEU A 215LEU A 217PHE A 261ALA A 265 | None | 1.37A | 5ieoA-1db3A:0.0 | 5ieoA-1db3A:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ded | CYCLODEXTRINGLUCANOTRANSFERASE (Bacillus sp.1011) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG)PF02806(Alpha-amylase_C) | 5 | LEU A 606PHE A 652PHE A 650PHE A 670ALA A 678 | None | 1.27A | 5ieoA-1dedA:2.7 | 5ieoA-1dedA:11.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ek6 | UDP-GALACTOSE4-EPIMERASE (Homo sapiens) |
PF16363(GDP_Man_Dehyd) | 5 | LEU A 76PHE A 77LEU A 127LEU A 116ALA A 89 | NoneNoneNoneNoneNAI A 400 (-3.7A) | 0.97A | 5ieoA-1ek6A:0.0 | 5ieoA-1ek6A:16.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gl9 | REVERSE GYRASE (Archaeoglobusfulgidus) |
PF00270(DEAD)PF01131(Topoisom_bac)PF01751(Toprim) | 5 | LEU B 484LEU B 452LEU B 267PHE B 481GLU B 255 | None | 1.33A | 5ieoA-1gl9B:2.9 | 5ieoA-1gl9B:10.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gwc | GLUTATHIONES-TRANSFERASE TSI-1 (Aegilopstauschii) |
PF00043(GST_C)PF02798(GST_N) | 5 | LEU A 73LEU A 87PHE A 199THR A 19ALA A 208 | None | 1.27A | 5ieoA-1gwcA:0.0 | 5ieoA-1gwcA:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1imv | PIGMENTEPITHELIUM-DERIVEDFACTOR (Homo sapiens) |
PF00079(Serpin) | 5 | LEU A 370TRP A 197LEU A 248PHE A 256PHE A 376 | None | 1.37A | 5ieoA-1imvA:undetectable | 5ieoA-1imvA:16.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1itu | RENAL DIPEPTIDASE (Homo sapiens) |
PF01244(Peptidase_M19) | 5 | LEU A 148LEU A 187PHE A 179THR A 156ALA A 159 | None | 1.32A | 5ieoA-1ituA:0.0 | 5ieoA-1ituA:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l1e | MYCOLIC ACIDSYNTHASE (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 5 | PHE A 191LEU A 236LEU A 266PHE A 200THR A 278 | None | 1.33A | 5ieoA-1l1eA:0.0 | 5ieoA-1l1eA:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l5a | AMIDE SYNTHASE (Vibrio cholerae) |
PF00668(Condensation) | 5 | PHE A 397LEU A 404LEU A 219PHE A 366ALA A 237 | None | 1.30A | 5ieoA-1l5aA:0.8 | 5ieoA-1l5aA:14.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m7s | CATALASE (Pseudomonassyringae) |
PF00199(Catalase)PF06628(Catalase-rel) | 5 | LEU A 464TYR A 486PHE A 185PHE A 188ALA A 194 | None | 1.35A | 5ieoA-1m7sA:undetectable | 5ieoA-1m7sA:13.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n5x | XANTHINEDEHYDROGENASE (Bos taurus) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 5 | LEU A 454PHE A 519LEU A 527LEU A 524PHE A 516 | None | 1.32A | 5ieoA-1n5xA:undetectable | 5ieoA-1n5xA:9.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q6y | HYPOTHETICAL PROTEINYFDW (Escherichiacoli) |
PF02515(CoA_transf_3) | 5 | PHE A 378LEU A 179LEU A 183PHE A 381ALA A 29 | None | 1.35A | 5ieoA-1q6yA:undetectable | 5ieoA-1q6yA:15.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rf5 | 5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATESYNTHASE (Streptococcuspneumoniae) |
PF00275(EPSP_synthase) | 5 | LEU A 276LEU A 240GLU A 280THR A 279ALA A 288 | None | 1.28A | 5ieoA-1rf5A:undetectable | 5ieoA-1rf5A:16.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ud9 | DNA POLYMERASESLIDING CLAMP A (Sulfurisphaeratokodaii) |
PF00705(PCNA_N)PF02747(PCNA_C) | 5 | LEU A 36LEU A 78PHE A 27PHE A 67THR A 71 | None | 1.36A | 5ieoA-1ud9A:undetectable | 5ieoA-1ud9A:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ued | P450 MONOOXYGENASE (Amycolatopsisorientalis) |
PF00067(p450) | 5 | PHE A 175LEU A 219LEU A 207PHE A 199ALA A 241 | NoneNoneNoneNonePG4 A4502 (-4.3A) | 1.24A | 5ieoA-1uedA:undetectable | 5ieoA-1uedA:16.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zl0 | HYPOTHETICAL PROTEINPA5198 (Pseudomonasaeruginosa) |
PF02016(Peptidase_S66) | 5 | LEU A 262PHE A 266LEU A 233LEU A 214PHE A 250 | None | 1.34A | 5ieoA-1zl0A:undetectable | 5ieoA-1zl0A:17.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2amc | PHENYLALANYL-TRNASYNTHETASE ALPHACHAIN (Thermusthermophilus) |
PF01409(tRNA-synt_2d) | 5 | LEU A 161LEU A 301PHE A 131GLU A 128ALA A 136 | None | 1.28A | 5ieoA-2amcA:undetectable | 5ieoA-2amcA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b9b | FUSION GLYCOPROTEINF0 (Mammalianrubulavirus 5) |
PF00523(Fusion_gly) | 5 | LEU A 79TYR A 199LEU A 228LEU A 224PHE A 207 | None | 1.29A | 5ieoA-2b9bA:undetectable | 5ieoA-2b9bA:13.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b9e | NOL1/NOP2/SUN DOMAINFAMILY, MEMBER 5ISOFORM 2 (Homo sapiens) |
PF01189(Methyltr_RsmB-F) | 5 | LEU A 287PHE A 286LEU A 354LEU A 351ALA A 373 | None | 1.24A | 5ieoA-2b9eA:undetectable | 5ieoA-2b9eA:18.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bbz | VIRAL CASP8 ANDFADD-LIKE APOPTOSISREGULATOR (Molluscumcontagiosumvirus) |
PF01335(DED) | 5 | LEU A 73LEU A 46LEU A 13PHE A 77ALA A 59 | None | 1.32A | 5ieoA-2bbzA:undetectable | 5ieoA-2bbzA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bzu | FIBER PROTEIN 2 (HumanmastadenovirusF) |
PF00541(Adeno_knob) | 5 | PHE A 374LEU A 252LEU A 286PHE A 349ALA A 379 | None | 1.26A | 5ieoA-2bzuA:undetectable | 5ieoA-2bzuA:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d42 | NON-TOXIC CRYSTALPROTEIN (Bacillusthuringiensis) |
PF03318(ETX_MTX2) | 5 | LEU A 108PHE A 164LEU A 133THR A 168ALA A 43 | None | 1.19A | 5ieoA-2d42A:undetectable | 5ieoA-2d42A:17.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e87 | HYPOTHETICAL PROTEINPH1320 (Pyrococcushorikoshii) |
PF06858(NOG1) | 5 | LEU A 85TYR A 78LEU A 246LEU A 243ALA A 195 | None | 1.22A | 5ieoA-2e87A:undetectable | 5ieoA-2e87A:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fef | HYPOTHETICAL PROTEINPA2201 (Pseudomonasaeruginosa) |
PF08929(DUF1911) | 5 | LEU A 49PHE A 52LEU A 117TRP A 76LEU A 8 | None | 1.36A | 5ieoA-2fefA:undetectable | 5ieoA-2fefA:17.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hne | L-FUCONATEDEHYDRATASE (Xanthomonascampestris) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | LEU A 153PHE A 150LEU A 166LEU A 144ALA A 342 | None | 1.27A | 5ieoA-2hneA:undetectable | 5ieoA-2hneA:14.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ho5 | OXIDOREDUCTASE,GFO/IDH/MOCA FAMILY (Streptococcuspneumoniae) |
PF01408(GFO_IDH_MocA) | 5 | LEU A 55PHE A 58LEU A 4LEU A 65ALA A 69 | None | 0.96A | 5ieoA-2ho5A:undetectable | 5ieoA-2ho5A:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2khq | INTEGRASE (Staphylococcussaprophyticus) |
PF14659(Phage_int_SAM_3) | 5 | LEU A 44PHE A 4LEU A 71LEU A 56PHE A 79 | None | 1.38A | 5ieoA-2khqA:undetectable | 5ieoA-2khqA:26.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nlv | XISI PROTEIN-LIKE (Trichormusvariabilis) |
PF08869(XisI) | 5 | LEU A 14PHE A 61LEU A 97LEU A 95THR A 75 | None | 1.24A | 5ieoA-2nlvA:undetectable | 5ieoA-2nlvA:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o8r | POLYPHOSPHATE KINASE (Porphyromonasgingivalis) |
PF02503(PP_kinase)PF13089(PP_kinase_N)PF13090(PP_kinase_C) | 5 | LEU A 47LEU A 661PHE A 50THR A 88ALA A 84 | None | 1.27A | 5ieoA-2o8rA:undetectable | 5ieoA-2o8rA:12.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pg6 | CYTOCHROME P450 2A6 (Homo sapiens) |
PF00067(p450) | 5 | LEU A 370PHE A 118LEU A 241LEU A 296THR A 212 | HEM A 500 ( 3.8A)NoneNoneNoneNone | 1.34A | 5ieoA-2pg6A:undetectable | 5ieoA-2pg6A:15.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q2r | GLUCOKINASE 1,PUTATIVE (Trypanosomacruzi) |
PF02685(Glucokinase) | 5 | LEU A 120PHE A 121PHE A 69PHE A 68ALA A 35 | None | 1.37A | 5ieoA-2q2rA:undetectable | 5ieoA-2q2rA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qyt | 2-DEHYDROPANTOATE2-REDUCTASE (Porphyromonasgingivalis) |
PF02558(ApbA)PF08546(ApbA_C) | 5 | LEU A 24LEU A 85PHE A 160THR A 179ALA A 175 | None | 1.34A | 5ieoA-2qytA:undetectable | 5ieoA-2qytA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r09 | CYTOHESIN-3 (Mus musculus) |
PF00169(PH)PF01369(Sec7) | 5 | LEU A 105LEU A 158LEU A 153PHE A 134ALA A 171 | None | 1.31A | 5ieoA-2r09A:undetectable | 5ieoA-2r09A:17.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rjb | UNCHARACTERIZEDPROTEIN (Shigellaflexneri) |
PF07063(DUF1338) | 5 | LEU A 261TYR A 433LEU A 119PHE A 388ALA A 110 | None | 1.31A | 5ieoA-2rjbA:undetectable | 5ieoA-2rjbA:15.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wpg | AMYLOSUCRASE ORALPHA AMYLASE (Xanthomonascampestris) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 5 | LEU A 46LEU A 64TRP A 60LEU A 61ALA A 309 | None | 1.20A | 5ieoA-2wpgA:undetectable | 5ieoA-2wpgA:11.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e8t | TAKEOUT-LIKE PROTEIN1 (Epiphyaspostvittana) |
PF06585(JHBP) | 5 | LEU A 51LEU A 116PHE A 49PHE A 47ALA A 196 | None | 1.30A | 5ieoA-3e8tA:3.0 | 5ieoA-3e8tA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f8k | PROTEINACETYLTRANSFERASE (Sulfolobussolfataricus) |
PF00583(Acetyltransf_1) | 5 | LEU A 21LEU A 25PHE A 34THR A 56ALA A 69 | None | 1.22A | 5ieoA-3f8kA:undetectable | 5ieoA-3f8kA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3flo | DNA POLYMERASE ALPHACATALYTIC SUBUNIT ADNA POLYMERASE ALPHASUBUNIT B (Saccharomycescerevisiae) |
PF04042(DNA_pol_E_B)PF08418(Pol_alpha_B_N)PF08996(zf-DNA_Pol) | 5 | LEU A 410LEU B1324LEU A 448PHE A 403ALA A 491 | None | 1.38A | 5ieoA-3floA:undetectable | 5ieoA-3floA:15.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3hx8 | PUTATIVE KETOSTEROIDISOMERASE (Mesorhizobiumloti) |
PF14534(DUF4440) | 5 | PHE A 36TYR A 52LEU A 75TRP A 76PHE A 107 | IMD A 4 (-3.6A)NoneNoneUNL A 200 (-4.9A)UNL A 200 (-3.6A) | 0.87A | 5ieoA-3hx8A:20.1 | 5ieoA-3hx8A:82.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ihy | PHOSPHATIDYLINOSITOL3-KINASE CATALYTICSUBUNIT TYPE 3 (Homo sapiens) |
PF00454(PI3_PI4_kinase)PF00613(PI3Ka) | 5 | LEU A 595LEU A 577LEU A 585PHE A 681ALA A 619 | None | 1.39A | 5ieoA-3ihyA:undetectable | 5ieoA-3ihyA:13.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ksx | NITRATE TRANSPORTPROTEIN (Xanthomonascitri) |
PF09084(NMT1) | 5 | LEU A 299PHE A 294LEU A 209LEU A 207ALA A 183 | None | 1.32A | 5ieoA-3ksxA:undetectable | 5ieoA-3ksxA:16.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l44 | GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE1 (Bacillusanthracis) |
PF00202(Aminotran_3) | 5 | PHE A 386LEU A 360LEU A 353PHE A 427THR A 419 | None | 1.15A | 5ieoA-3l44A:undetectable | 5ieoA-3l44A:16.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n90 | THYLAKOID LUMENAL 15KDA PROTEIN 1,CHLOROPLASTIC (Arabidopsisthaliana) |
PF00805(Pentapeptide) | 5 | LEU A 202LEU A 138LEU A 143PHE A 189THR A 177 | None | 1.17A | 5ieoA-3n90A:undetectable | 5ieoA-3n90A:24.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ojl | CAP5O (Staphylococcusaureus) |
PF00984(UDPG_MGDP_dh)PF03720(UDPG_MGDP_dh_C)PF03721(UDPG_MGDP_dh_N) | 5 | LEU A 379PHE A 376LEU A 312THR A 308ALA A 360 | None | 1.21A | 5ieoA-3ojlA:undetectable | 5ieoA-3ojlA:15.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s4l | CAS3 METAL DEPENDENTPHOSPHOHYDROLASE (Methanocaldococcusjannaschii) |
no annotation | 5 | PHE A 58LEU A 215LEU A 212THR A 99ALA A 96 | None | 1.37A | 5ieoA-3s4lA:undetectable | 5ieoA-3s4lA:24.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s5k | FALCILYSIN (Plasmodiumfalciparum) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C)PF08367(M16C_assoc) | 5 | LEU A 929PHE A 958PHE A 746PHE A 815ALA A 792 | None | 1.22A | 5ieoA-3s5kA:undetectable | 5ieoA-3s5kA:7.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s5w | L-ORNITHINE5-MONOOXYGENASE (Pseudomonasaeruginosa) |
PF13434(K_oxygenase) | 5 | LEU A 44LEU A 367LEU A 364THR A 161ALA A 163 | None | 1.20A | 5ieoA-3s5wA:undetectable | 5ieoA-3s5wA:16.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sfz | APOPTOTIC PEPTIDASEACTIVATING FACTOR 1 (Mus musculus) |
PF00400(WD40)PF00931(NB-ARC)PF12894(ANAPC4_WD40) | 5 | LEU A 758LEU A 730LEU A 714PHE A 751ALA A 664 | None | 1.11A | 5ieoA-3sfzA:2.6 | 5ieoA-3sfzA:7.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wsy | SORTILIN-RELATEDRECEPTOR (Homo sapiens) |
PF15901(Sortilin_C)PF15902(Sortilin-Vps10) | 5 | LEU A 503LEU A 475TRP A 530LEU A 477ALA A 533 | None | 1.34A | 5ieoA-3wsyA:undetectable | 5ieoA-3wsyA:11.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zl8 | UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D-ALANINE LIGASE (Thermotogamaritima) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | PHE A 249LEU A 103LEU A 287PHE A 242ALA A 267 | None | 1.30A | 5ieoA-3zl8A:undetectable | 5ieoA-3zl8A:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c2x | GLYCYLPEPTIDEN-TETRADECANOYLTRANSFERASE 2 (Homo sapiens) |
PF01233(NMT)PF02799(NMT_C) | 5 | LEU A 462PHE A 461LEU A 398PHE A 467ALA A 419 | None | 1.24A | 5ieoA-4c2xA:undetectable | 5ieoA-4c2xA:16.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cp2 | EPITHELIAL ADHESIN 9 ([Candida]glabrata) |
PF10528(GLEYA) | 5 | LEU A 238PHE A 191LEU A 283PHE A 201ALA A 208 | None | 1.37A | 5ieoA-4cp2A:undetectable | 5ieoA-4cp2A:17.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fzw | 2,3-DEHYDROADIPYL-COA HYDRATASE (Escherichiacoli) |
PF00378(ECH_1) | 5 | LEU A 127LEU A 31TRP A 85LEU A 88ALA A 60 | None | 1.35A | 5ieoA-4fzwA:undetectable | 5ieoA-4fzwA:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gbm | CURMSULFOTRANSFERASE (Mooreaproducens) |
PF13469(Sulfotransfer_3) | 5 | LEU A 236PHE A 235LEU A 205LEU A 208PHE A 33 | None | 1.19A | 5ieoA-4gbmA:undetectable | 5ieoA-4gbmA:16.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gip | FUSION GLYCOPROTEINF1FUSION GLYCOPROTEINF2 (Mammalianrubulavirus 5) |
PF00523(Fusion_gly) | 5 | LEU A 79TYR D 199LEU D 228LEU D 224PHE D 207 | None | 1.27A | 5ieoA-4gipA:undetectable | 5ieoA-4gipA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h7n | ALDEHYDEDEHYDROGENASE (Trichormusvariabilis) |
PF00171(Aldedh) | 5 | LEU A 89LEU A 179TRP A 56LEU A 183PHE A 88 | None | 1.36A | 5ieoA-4h7nA:undetectable | 5ieoA-4h7nA:15.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4igb | LPXTG CELL WALLSURFACE PROTEIN (Streptococcusgordonii) |
no annotation | 5 | LEU D 283LEU D 285PHE D 306GLU D 169ALA D 304 | NoneNoneNoneSO4 D 501 ( 4.2A) NA D 504 ( 4.5A) | 1.21A | 5ieoA-4igbD:1.5 | 5ieoA-4igbD:13.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4irl | MALTOSE-BINDINGPERIPLASMIC PROTEIN,NOVEL PROTEINSIMILAR TOVERTEBRATE GUANYLATEBINDING PROTEINFAMILY (Danio rerio;Escherichiacoli) |
PF00619(CARD)PF13416(SBP_bac_8) | 5 | LEU A 431PHE A 442LEU A 453LEU A 457PHE A 428 | None | 1.22A | 5ieoA-4irlA:undetectable | 5ieoA-4irlA:13.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ixo | NIFS-LIKE PROTEIN (Rickettsiaafricae) |
PF00266(Aminotran_5) | 5 | LEU A 302PHE A 305TYR A 367LEU A 269LEU A 265 | None | 1.24A | 5ieoA-4ixoA:undetectable | 5ieoA-4ixoA:18.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j8s | CCR4-NOTTRANSCRIPTIONCOMPLEX SUBUNIT 1 (Homo sapiens) |
PF16417(CNOT1_TTP_bind) | 5 | LEU A 885PHE A 886LEU A 925LEU A 921ALA A 947 | None | 1.36A | 5ieoA-4j8sA:undetectable | 5ieoA-4j8sA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kd6 | ENOYL-COAHYDRATASE/ISOMERASE (Paraburkholderiagraminis) |
PF00378(ECH_1) | 5 | LEU A 176LEU A 92LEU A 99PHE A 61ALA A 111 | None | 1.35A | 5ieoA-4kd6A:undetectable | 5ieoA-4kd6A:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kds | PLASMINOGENACTIVATOR INHIBITOR1 (Oncorhynchusmykiss) |
PF00079(Serpin) | 5 | LEU A 107LEU A 55LEU A 59PHE A 111ALA A 335 | None | 1.37A | 5ieoA-4kdsA:undetectable | 5ieoA-4kdsA:17.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kf6 | GLYCOLIPID TRANSFERPROTEINDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF08718(GLTP) | 5 | PHE A 171LEU A 43LEU A 118PHE A 162ALA A 161 | None | 1.26A | 5ieoA-4kf6A:undetectable | 5ieoA-4kf6A:16.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l9m | RAS GUANYL-RELEASINGPROTEIN 1 (Homo sapiens) |
PF00130(C1_1)PF00617(RasGEF)PF00618(RasGEF_N)PF13405(EF-hand_6) | 5 | LEU A 417TRP A 257LEU A 413PHE A 278ALA A 296 | None | 1.29A | 5ieoA-4l9mA:undetectable | 5ieoA-4l9mA:11.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4maa | PUTATIVEBRANCHED-CHAIN AMINOACID ABCTRANSPORTER,PERIPLASMIC AMINOACID-BINDING PROTEIN (Pseudomonasprotegens) |
PF13458(Peripla_BP_6) | 5 | LEU A 110LEU A 205PHE A 178GLU A 131ALA A 181 | NoneNoneGOL A 503 ( 4.0A)NoneNone | 1.35A | 5ieoA-4maaA:undetectable | 5ieoA-4maaA:15.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mx3 | CAMP-DEPENDENTPROTEIN KINASE TYPEI-ALPHA REGULATORYSUBUNIT (Bos taurus) |
PF00027(cNMP_binding) | 5 | LEU A 327LEU A 257LEU A 254PHE A 290ALA A 268 | None | 1.35A | 5ieoA-4mx3A:undetectable | 5ieoA-4mx3A:18.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nz0 | GENOME POLYPROTEIN (Cardiovirus A) |
PF00680(RdRP_1) | 6 | LEU A 251PHE A 255TYR A 75LEU A 206LEU A 83PHE A 256 | None | 1.41A | 5ieoA-4nz0A:undetectable | 5ieoA-4nz0A:15.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oqr | CYP105AS1 (Amycolatopsisorientalis) |
PF00067(p450) | 5 | LEU A 372LEU A 328LEU A 330PHE A 366PHE A 362 | None | 1.31A | 5ieoA-4oqrA:undetectable | 5ieoA-4oqrA:14.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oqs | CYP105AS1 (Amycolatopsisorientalis) |
PF00067(p450) | 5 | LEU A 372LEU A 328LEU A 330PHE A 366PHE A 362 | None | 1.28A | 5ieoA-4oqsA:undetectable | 5ieoA-4oqsA:15.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p0f | SERINE PROTEASEINHIBITOR 4, ISOFORMB (Drosophilamelanogaster) |
PF00079(Serpin) | 5 | LEU A 13PHE A 16LEU A 281LEU A 24ALA A 332 | None | 1.11A | 5ieoA-4p0fA:undetectable | 5ieoA-4p0fA:16.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p0f | SERINE PROTEASEINHIBITOR 4, ISOFORMB (Drosophilamelanogaster) |
PF00079(Serpin) | 5 | LEU A 112PHE A 116LEU A 65LEU A 63ALA A 51 | None | 1.39A | 5ieoA-4p0fA:undetectable | 5ieoA-4p0fA:16.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pbv | NT-3 GROWTH FACTORRECEPTOR (Gallus gallus) |
PF00047(ig)PF13855(LRR_8)PF16920(TPKR_C2) | 5 | LEU A 152LEU A 115LEU A 139PHE A 147ALA A 122 | None | 1.00A | 5ieoA-4pbvA:undetectable | 5ieoA-4pbvA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pht | GENERAL SECRETORYPATHWAY PROTEIN E (Vibriovulnificus) |
PF00437(T2SSE) | 5 | PHE A 69LEU A 37LEU A 26PHE A 18ALA A 47 | None | 1.31A | 5ieoA-4phtA:undetectable | 5ieoA-4phtA:15.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uqm | URACIL-DNAGLYCOSYLASE (Deinococcusradiodurans) |
PF03167(UDG) | 5 | LEU A 43LEU A 67LEU A 23PHE A 40ALA A 166 | None | 1.16A | 5ieoA-4uqmA:undetectable | 5ieoA-4uqmA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uqm | URACIL-DNAGLYCOSYLASE (Deinococcusradiodurans) |
PF03167(UDG) | 5 | LEU A 43LEU A 67LEU A 23PHE A 40THR A 164 | None | 1.35A | 5ieoA-4uqmA:undetectable | 5ieoA-4uqmA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uvq | THIAZOLINEOXIDASE/SUBTILISIN-LIKE PROTEASE (Prochloron sp.) |
no annotation | 5 | PHE A1149LEU A1078PHE A1162THR A1108ALA A1111 | None | 1.11A | 5ieoA-4uvqA:2.8 | 5ieoA-4uvqA:17.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b3k | UNCHARACTERIZEDPROTEIN PA3435 (Pseudomonasaeruginosa) |
PF00258(Flavodoxin_1) | 5 | LEU A 78LEU A 63LEU A 67PHE A 111GLU A 113 | None | 1.22A | 5ieoA-5b3kA:undetectable | 5ieoA-5b3kA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b7i | CRISPR-ASSOCIATEDNUCLEASE/HELICASECAS3 SUBTYPEI-F/YPEST (Pseudomonasaeruginosa) |
no annotation | 5 | PHE A 157LEU A 171TRP A 170LEU A 209THR A 277 | None | 1.33A | 5ieoA-5b7iA:undetectable | 5ieoA-5b7iA:8.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d9a | POLYMERASE ACIDICPROTEINRNA-DIRECTED RNAPOLYMERASE CATALYTICSUBUNIT (Influenza Cvirus) |
PF00602(Flu_PB1)PF00603(Flu_PA) | 5 | LEU B 238LEU A 671LEU A 670PHE A 642ALA A 688 | None | 1.34A | 5ieoA-5d9aB:undetectable | 5ieoA-5d9aB:12.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dmn | HOMOCYSTEINES-METHYLTRANSFERASE (Escherichiacoli) |
PF02574(S-methyl_trans) | 5 | LEU A 203LEU A 248PHE A 195PHE A 193ALA A 180 | None | 0.96A | 5ieoA-5dmnA:undetectable | 5ieoA-5dmnA:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eo6 | COPROPORPHYRINOGENOXIDASE (Acinetobacterbaumannii) |
PF01218(Coprogen_oxidas) | 5 | LEU A 58LEU A 223LEU A 219PHE A 40GLU A 31 | None | 1.29A | 5ieoA-5eo6A:1.4 | 5ieoA-5eo6A:17.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fcl | CRISPR-ASSOCIATEDENDONUCLEASE CAS1 (Pectobacteriumatrosepticum) |
PF01867(Cas_Cas1) | 5 | TYR A 23LEU A 298LEU A 233PHE A 93THR A 63 | None | 1.38A | 5ieoA-5fclA:undetectable | 5ieoA-5fclA:16.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5foz | LARVICIDAL TOXINPROTEIN (Lysinibacillussphaericus) |
PF05431(Toxin_10) | 5 | LEU B 406PHE B 423PHE B 429GLU B 287ALA B 364 | None | 1.37A | 5ieoA-5fozB:2.8 | 5ieoA-5fozB:15.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hra | ASPARTATE/GLUTAMATERACEMASE (Escherichiacoli) |
PF01177(Asp_Glu_race) | 5 | TYR A 18LEU A 81LEU A 64PHE A 45THR A 198 | NoneNoneNoneNoneDAS A 301 (-3.2A) | 1.35A | 5ieoA-5hraA:undetectable | 5ieoA-5hraA:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hvn | 3-DEHYDROQUINATESYNTHASE (Francisellatularensis) |
PF01761(DHQ_synthase) | 5 | LEU A 334PHE A 332LEU A 320LEU A 316PHE A 278 | None | 1.38A | 5ieoA-5hvnA:undetectable | 5ieoA-5hvnA:15.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i5h | INNER MEMBRANEPROTEIN YEJM (Escherichiacoli) |
PF00884(Sulfatase)PF11893(DUF3413) | 5 | LEU A 358LEU A 494LEU A 498PHE A 362THR A 266 | None | 1.34A | 5ieoA-5i5hA:undetectable | 5ieoA-5i5hA:15.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jd9 | SPORE COAT PROTEIN H (Bacillus cereus) |
PF08757(CotH) | 5 | PHE A 299TYR A 342PHE A 93PHE A 94THR A 250 | None | 1.17A | 5ieoA-5jd9A:undetectable | 5ieoA-5jd9A:17.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5khn | RND TRANSPORTER (Burkholderiamultivorans) |
no annotation | 5 | PHE B 541TRP B 661LEU B 669GLU B 503ALA B 505 | None | 1.14A | 5ieoA-5khnB:undetectable | 5ieoA-5khnB:9.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m45 | ACETONE CARBOXYLASEBETA SUBUNIT (Xanthobacterautotrophicus) |
PF01968(Hydantoinase_A)PF05378(Hydant_A_N) | 5 | PHE B 503TYR B 295LEU B 300LEU B 711PHE B 34 | None | 1.31A | 5ieoA-5m45B:undetectable | 5ieoA-5m45B:11.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o5o | RNASE ADAPTERPROTEIN RAPZ (Escherichiacoli) |
PF03668(ATP_bind_2) | 5 | LEU A 261PHE A 265LEU A 233LEU A 160PHE A 164 | None | 1.26A | 5ieoA-5o5oA:undetectable | 5ieoA-5o5oA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o5s | RNASE ADAPTERPROTEIN RAPZ (Escherichiacoli) |
PF03668(ATP_bind_2) | 5 | LEU A 261PHE A 265LEU A 233LEU A 160PHE A 164 | None | 1.32A | 5ieoA-5o5sA:undetectable | 5ieoA-5o5sA:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5of2 | SPORECOAT-ASSOCIATEDPROTEIN N (Bacillussubtilis) |
no annotation | 5 | LEU A 46LEU A 113PHE A 72PHE A 70ALA A 53 | None | 1.24A | 5ieoA-5of2A:undetectable | 5ieoA-5of2A:24.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uto | EDD DOMAIN PROTEIN,DEGV FAMILY (Staphylococcusaureus) |
no annotation | 5 | LEU A 168PHE A 263GLU A 40THR A 10ALA A 122 | NonePLM A 301 ( 4.8A)NoneNonePLM A 301 ( 4.5A) | 1.23A | 5ieoA-5utoA:undetectable | 5ieoA-5utoA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vha | DEAH(ASP-GLU-ALA-HIS)BOX POLYPEPTIDE 36 (Bos taurus) |
no annotation | 5 | LEU A 807PHE A 812LEU A 955LEU A 982ALA A 839 | None | 1.25A | 5ieoA-5vhaA:undetectable | 5ieoA-5vhaA:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xxg | - (-) |
no annotation | 5 | LEU A 36PHE A 126LEU A 171LEU A 165PHE A 110 | None | 1.28A | 5ieoA-5xxgA:undetectable | 5ieoA-5xxgA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y58 | ATP-DEPENDENT DNAHELICASE II SUBUNIT1 (Saccharomycescerevisiae) |
no annotation | 5 | LEU A 38PHE A 129LEU A 115LEU A 111PHE A 82 | None | 1.28A | 5ieoA-5y58A:2.2 | 5ieoA-5y58A:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6axf | RAS GUANYL-RELEASINGPROTEIN 2 (Homo sapiens) |
no annotation | 5 | LEU A 368TRP A 206LEU A 364PHE A 227ALA A 245 | None | 1.05A | 5ieoA-6axfA:undetectable | 5ieoA-6axfA:15.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6axg | RAS GUANYL-RELEASINGPROTEIN 4 (Homo sapiens) |
no annotation | 5 | LEU A 413TRP A 253LEU A 409PHE A 274ALA A 292 | None | 1.06A | 5ieoA-6axgA:undetectable | 5ieoA-6axgA:13.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bbp | CYTOHESIN-3,ADP-RIBOSYLATION FACTOR 6 (Homo sapiens;Mus musculus) |
no annotation | 5 | LEU A 105LEU A 158LEU A 153PHE A 134ALA A 171 | None | 1.31A | 5ieoA-6bbpA:undetectable | 5ieoA-6bbpA:23.02 |