SIMILAR PATTERNS OF AMINO ACIDS FOR 5IEO_A_VDYA206

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1db3 GDP-MANNOSE
4,6-DEHYDRATASE

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		5 PHE A 275
LEU A 215
LEU A 217
PHE A 261
ALA A 265
 None
 1.37A 5ieoA-1db3A:
0.0		 5ieoA-1db3A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 LEU A 606
PHE A 652
PHE A 650
PHE A 670
ALA A 678
 None
 1.27A 5ieoA-1dedA:
2.7		 5ieoA-1dedA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ek6 UDP-GALACTOSE
4-EPIMERASE

(Homo sapiens) 		PF16363
(GDP_Man_Dehyd) 		5 LEU A  76
PHE A  77
LEU A 127
LEU A 116
ALA A  89
 None
None
None
None
NAI  A 400 (-3.7A)
 0.97A 5ieoA-1ek6A:
0.0		 5ieoA-1ek6A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 LEU B 484
LEU B 452
LEU B 267
PHE B 481
GLU B 255
 None
 1.33A 5ieoA-1gl9B:
2.9		 5ieoA-1gl9B:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gwc GLUTATHIONE
S-TRANSFERASE TSI-1

(Aegilops
tauschii) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 LEU A  73
LEU A  87
PHE A 199
THR A  19
ALA A 208
 None
 1.27A 5ieoA-1gwcA:
0.0		 5ieoA-1gwcA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imv PIGMENT
EPITHELIUM-DERIVED
FACTOR

(Homo sapiens) 		PF00079
(Serpin) 		5 LEU A 370
TRP A 197
LEU A 248
PHE A 256
PHE A 376
 None
 1.37A 5ieoA-1imvA:
undetectable		 5ieoA-1imvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itu RENAL DIPEPTIDASE

(Homo sapiens) 		PF01244
(Peptidase_M19) 		5 LEU A 148
LEU A 187
PHE A 179
THR A 156
ALA A 159
 None
 1.32A 5ieoA-1ituA:
0.0		 5ieoA-1ituA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1e MYCOLIC ACID
SYNTHASE

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		5 PHE A 191
LEU A 236
LEU A 266
PHE A 200
THR A 278
 None
 1.33A 5ieoA-1l1eA:
0.0		 5ieoA-1l1eA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5a AMIDE SYNTHASE

(Vibrio cholerae) 		PF00668
(Condensation) 		5 PHE A 397
LEU A 404
LEU A 219
PHE A 366
ALA A 237
 None
 1.30A 5ieoA-1l5aA:
0.8		 5ieoA-1l5aA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7s CATALASE

(Pseudomonas
syringae) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 LEU A 464
TYR A 486
PHE A 185
PHE A 188
ALA A 194
 None
 1.35A 5ieoA-1m7sA:
undetectable		 5ieoA-1m7sA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 LEU A 454
PHE A 519
LEU A 527
LEU A 524
PHE A 516
 None
 1.32A 5ieoA-1n5xA:
undetectable		 5ieoA-1n5xA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6y HYPOTHETICAL PROTEIN
YFDW

(Escherichia
coli) 		PF02515
(CoA_transf_3) 		5 PHE A 378
LEU A 179
LEU A 183
PHE A 381
ALA A  29
 None
 1.35A 5ieoA-1q6yA:
undetectable		 5ieoA-1q6yA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		5 LEU A 276
LEU A 240
GLU A 280
THR A 279
ALA A 288
 None
 1.28A 5ieoA-1rf5A:
undetectable		 5ieoA-1rf5A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ud9 DNA POLYMERASE
SLIDING CLAMP A

(Sulfurisphaera
tokodaii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 LEU A  36
LEU A  78
PHE A  27
PHE A  67
THR A  71
 None
 1.36A 5ieoA-1ud9A:
undetectable		 5ieoA-1ud9A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ued P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		5 PHE A 175
LEU A 219
LEU A 207
PHE A 199
ALA A 241
 None
None
None
None
PG4  A4502 (-4.3A)
 1.24A 5ieoA-1uedA:
undetectable		 5ieoA-1uedA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl0 HYPOTHETICAL PROTEIN
PA5198

(Pseudomonas
aeruginosa) 		PF02016
(Peptidase_S66) 		5 LEU A 262
PHE A 266
LEU A 233
LEU A 214
PHE A 250
 None
 1.34A 5ieoA-1zl0A:
undetectable		 5ieoA-1zl0A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d) 		5 LEU A 161
LEU A 301
PHE A 131
GLU A 128
ALA A 136
 None
 1.28A 5ieoA-2amcA:
undetectable		 5ieoA-2amcA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9b FUSION GLYCOPROTEIN
F0

(Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly) 		5 LEU A  79
TYR A 199
LEU A 228
LEU A 224
PHE A 207
 None
 1.29A 5ieoA-2b9bA:
undetectable		 5ieoA-2b9bA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		5 LEU A 287
PHE A 286
LEU A 354
LEU A 351
ALA A 373
 None
 1.24A 5ieoA-2b9eA:
undetectable		 5ieoA-2b9eA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbz VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR

(Molluscum
contagiosum
virus) 		PF01335
(DED) 		5 LEU A  73
LEU A  46
LEU A  13
PHE A  77
ALA A  59
 None
 1.32A 5ieoA-2bbzA:
undetectable		 5ieoA-2bbzA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzu FIBER PROTEIN 2

(Human
mastadenovirus
F) 		PF00541
(Adeno_knob) 		5 PHE A 374
LEU A 252
LEU A 286
PHE A 349
ALA A 379
 None
 1.26A 5ieoA-2bzuA:
undetectable		 5ieoA-2bzuA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d42 NON-TOXIC CRYSTAL
PROTEIN

(Bacillus
thuringiensis) 		PF03318
(ETX_MTX2) 		5 LEU A 108
PHE A 164
LEU A 133
THR A 168
ALA A  43
 None
 1.19A 5ieoA-2d42A:
undetectable		 5ieoA-2d42A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e87 HYPOTHETICAL PROTEIN
PH1320

(Pyrococcus
horikoshii) 		PF06858
(NOG1) 		5 LEU A  85
TYR A  78
LEU A 246
LEU A 243
ALA A 195
 None
 1.22A 5ieoA-2e87A:
undetectable		 5ieoA-2e87A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fef HYPOTHETICAL PROTEIN
PA2201

(Pseudomonas
aeruginosa) 		PF08929
(DUF1911) 		5 LEU A  49
PHE A  52
LEU A 117
TRP A  76
LEU A   8
 None
 1.36A 5ieoA-2fefA:
undetectable		 5ieoA-2fefA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hne L-FUCONATE
DEHYDRATASE

(Xanthomonas
campestris) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 153
PHE A 150
LEU A 166
LEU A 144
ALA A 342
 None
 1.27A 5ieoA-2hneA:
undetectable		 5ieoA-2hneA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Streptococcus
pneumoniae) 		PF01408
(GFO_IDH_MocA) 		5 LEU A  55
PHE A  58
LEU A   4
LEU A  65
ALA A  69
 None
 0.96A 5ieoA-2ho5A:
undetectable		 5ieoA-2ho5A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2khq INTEGRASE

(Staphylococcus
saprophyticus) 		PF14659
(Phage_int_SAM_3) 		5 LEU A  44
PHE A   4
LEU A  71
LEU A  56
PHE A  79
 None
 1.38A 5ieoA-2khqA:
undetectable		 5ieoA-2khqA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlv XISI PROTEIN-LIKE

(Trichormus
variabilis) 		PF08869
(XisI) 		5 LEU A  14
PHE A  61
LEU A  97
LEU A  95
THR A  75
 None
 1.24A 5ieoA-2nlvA:
undetectable		 5ieoA-2nlvA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8r POLYPHOSPHATE KINASE

(Porphyromonas
gingivalis) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		5 LEU A  47
LEU A 661
PHE A  50
THR A  88
ALA A  84
 None
 1.27A 5ieoA-2o8rA:
undetectable		 5ieoA-2o8rA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 370
PHE A 118
LEU A 241
LEU A 296
THR A 212
 HEM  A 500 ( 3.8A)
None
None
None
None
 1.34A 5ieoA-2pg6A:
undetectable		 5ieoA-2pg6A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2r GLUCOKINASE 1,
PUTATIVE

(Trypanosoma
cruzi) 		PF02685
(Glucokinase) 		5 LEU A 120
PHE A 121
PHE A  69
PHE A  68
ALA A  35
 None
 1.37A 5ieoA-2q2rA:
undetectable		 5ieoA-2q2rA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyt 2-DEHYDROPANTOATE
2-REDUCTASE

(Porphyromonas
gingivalis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 LEU A  24
LEU A  85
PHE A 160
THR A 179
ALA A 175
 None
 1.34A 5ieoA-2qytA:
undetectable		 5ieoA-2qytA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r09 CYTOHESIN-3

(Mus musculus) 		PF00169
(PH)
PF01369
(Sec7) 		5 LEU A 105
LEU A 158
LEU A 153
PHE A 134
ALA A 171
 None
 1.31A 5ieoA-2r09A:
undetectable		 5ieoA-2r09A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjb UNCHARACTERIZED
PROTEIN

(Shigella
flexneri) 		PF07063
(DUF1338) 		5 LEU A 261
TYR A 433
LEU A 119
PHE A 388
ALA A 110
 None
 1.31A 5ieoA-2rjbA:
undetectable		 5ieoA-2rjbA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE

(Xanthomonas
campestris) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 LEU A  46
LEU A  64
TRP A  60
LEU A  61
ALA A 309
 None
 1.20A 5ieoA-2wpgA:
undetectable		 5ieoA-2wpgA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8t TAKEOUT-LIKE PROTEIN
1

(Epiphyas
postvittana) 		PF06585
(JHBP) 		5 LEU A  51
LEU A 116
PHE A  49
PHE A  47
ALA A 196
 None
 1.30A 5ieoA-3e8tA:
3.0		 5ieoA-3e8tA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8k PROTEIN
ACETYLTRANSFERASE

(Sulfolobus
solfataricus) 		PF00583
(Acetyltransf_1) 		5 LEU A  21
LEU A  25
PHE A  34
THR A  56
ALA A  69
 None
 1.22A 5ieoA-3f8kA:
undetectable		 5ieoA-3f8kA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flo DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
DNA POLYMERASE ALPHA
SUBUNIT B

(Saccharomyces
cerevisiae) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N)
PF08996
(zf-DNA_Pol) 		5 LEU A 410
LEU B1324
LEU A 448
PHE A 403
ALA A 491
 None
 1.38A 5ieoA-3floA:
undetectable		 5ieoA-3floA:
15.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hx8 PUTATIVE KETOSTEROID
ISOMERASE

(Mesorhizobium
loti) 		PF14534
(DUF4440) 		5 PHE A  36
TYR A  52
LEU A  75
TRP A  76
PHE A 107
 IMD  A   4 (-3.6A)
None
None
UNL  A 200 (-4.9A)
UNL  A 200 (-3.6A)
 0.87A 5ieoA-3hx8A:
20.1		 5ieoA-3hx8A:
82.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		5 LEU A 595
LEU A 577
LEU A 585
PHE A 681
ALA A 619
 None
 1.39A 5ieoA-3ihyA:
undetectable		 5ieoA-3ihyA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksx NITRATE TRANSPORT
PROTEIN

(Xanthomonas
citri) 		PF09084
(NMT1) 		5 LEU A 299
PHE A 294
LEU A 209
LEU A 207
ALA A 183
 None
 1.32A 5ieoA-3ksxA:
undetectable		 5ieoA-3ksxA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		5 PHE A 386
LEU A 360
LEU A 353
PHE A 427
THR A 419
 None
 1.15A 5ieoA-3l44A:
undetectable		 5ieoA-3l44A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n90 THYLAKOID LUMENAL 15
KDA PROTEIN 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00805
(Pentapeptide) 		5 LEU A 202
LEU A 138
LEU A 143
PHE A 189
THR A 177
 None
 1.17A 5ieoA-3n90A:
undetectable		 5ieoA-3n90A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojl CAP5O

(Staphylococcus
aureus) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 LEU A 379
PHE A 376
LEU A 312
THR A 308
ALA A 360
 None
 1.21A 5ieoA-3ojlA:
undetectable		 5ieoA-3ojlA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE

(Methanocaldococcus
jannaschii) 		no annotation 5 PHE A  58
LEU A 215
LEU A 212
THR A  99
ALA A  96
 None
 1.37A 5ieoA-3s4lA:
undetectable		 5ieoA-3s4lA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 LEU A 929
PHE A 958
PHE A 746
PHE A 815
ALA A 792
 None
 1.22A 5ieoA-3s5kA:
undetectable		 5ieoA-3s5kA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5w L-ORNITHINE
5-MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF13434
(K_oxygenase) 		5 LEU A  44
LEU A 367
LEU A 364
THR A 161
ALA A 163
 None
 1.20A 5ieoA-3s5wA:
undetectable		 5ieoA-3s5wA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		5 LEU A 758
LEU A 730
LEU A 714
PHE A 751
ALA A 664
 None
 1.11A 5ieoA-3sfzA:
2.6		 5ieoA-3sfzA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsy SORTILIN-RELATED
RECEPTOR

(Homo sapiens) 		PF15901
(Sortilin_C)
PF15902
(Sortilin-Vps10) 		5 LEU A 503
LEU A 475
TRP A 530
LEU A 477
ALA A 533
 None
 1.34A 5ieoA-3wsyA:
undetectable		 5ieoA-3wsyA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 PHE A 249
LEU A 103
LEU A 287
PHE A 242
ALA A 267
 None
 1.30A 5ieoA-3zl8A:
undetectable		 5ieoA-3zl8A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 LEU A 462
PHE A 461
LEU A 398
PHE A 467
ALA A 419
 None
 1.24A 5ieoA-4c2xA:
undetectable		 5ieoA-4c2xA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp2 EPITHELIAL ADHESIN 9

([Candida]
glabrata) 		PF10528
(GLEYA) 		5 LEU A 238
PHE A 191
LEU A 283
PHE A 201
ALA A 208
 None
 1.37A 5ieoA-4cp2A:
undetectable		 5ieoA-4cp2A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE

(Escherichia
coli) 		PF00378
(ECH_1) 		5 LEU A 127
LEU A  31
TRP A  85
LEU A  88
ALA A  60
 None
 1.35A 5ieoA-4fzwA:
undetectable		 5ieoA-4fzwA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbm CURM
SULFOTRANSFERASE

(Moorea
producens) 		PF13469
(Sulfotransfer_3) 		5 LEU A 236
PHE A 235
LEU A 205
LEU A 208
PHE A  33
 None
 1.19A 5ieoA-4gbmA:
undetectable		 5ieoA-4gbmA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gip FUSION GLYCOPROTEIN
F1
FUSION GLYCOPROTEIN
F2

(Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly) 		5 LEU A  79
TYR D 199
LEU D 228
LEU D 224
PHE D 207
 None
 1.27A 5ieoA-4gipA:
undetectable		 5ieoA-4gipA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7n ALDEHYDE
DEHYDROGENASE

(Trichormus
variabilis) 		PF00171
(Aldedh) 		5 LEU A  89
LEU A 179
TRP A  56
LEU A 183
PHE A  88
 None
 1.36A 5ieoA-4h7nA:
undetectable		 5ieoA-4h7nA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igb LPXTG CELL WALL
SURFACE PROTEIN

(Streptococcus
gordonii) 		no annotation 5 LEU D 283
LEU D 285
PHE D 306
GLU D 169
ALA D 304
 None
None
None
SO4  D 501 ( 4.2A)
NA  D 504 ( 4.5A)
 1.21A 5ieoA-4igbD:
1.5		 5ieoA-4igbD:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irl MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NOVEL PROTEIN
SIMILAR TO
VERTEBRATE GUANYLATE
BINDING PROTEIN
FAMILY

(Danio rerio;
Escherichia
coli) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 LEU A 431
PHE A 442
LEU A 453
LEU A 457
PHE A 428
 None
 1.22A 5ieoA-4irlA:
undetectable		 5ieoA-4irlA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixo NIFS-LIKE PROTEIN

(Rickettsia
africae) 		PF00266
(Aminotran_5) 		5 LEU A 302
PHE A 305
TYR A 367
LEU A 269
LEU A 265
 None
 1.24A 5ieoA-4ixoA:
undetectable		 5ieoA-4ixoA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8s CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF16417
(CNOT1_TTP_bind) 		5 LEU A 885
PHE A 886
LEU A 925
LEU A 921
ALA A 947
 None
 1.36A 5ieoA-4j8sA:
undetectable		 5ieoA-4j8sA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kd6 ENOYL-COA
HYDRATASE/ISOMERASE

(Paraburkholderia
graminis) 		PF00378
(ECH_1) 		5 LEU A 176
LEU A  92
LEU A  99
PHE A  61
ALA A 111
 None
 1.35A 5ieoA-4kd6A:
undetectable		 5ieoA-4kd6A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Oncorhynchus
mykiss) 		PF00079
(Serpin) 		5 LEU A 107
LEU A  55
LEU A  59
PHE A 111
ALA A 335
 None
 1.37A 5ieoA-4kdsA:
undetectable		 5ieoA-4kdsA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf6 GLYCOLIPID TRANSFER
PROTEIN
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF08718
(GLTP) 		5 PHE A 171
LEU A  43
LEU A 118
PHE A 162
ALA A 161
 None
 1.26A 5ieoA-4kf6A:
undetectable		 5ieoA-4kf6A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9m RAS GUANYL-RELEASING
PROTEIN 1

(Homo sapiens) 		PF00130
(C1_1)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF13405
(EF-hand_6) 		5 LEU A 417
TRP A 257
LEU A 413
PHE A 278
ALA A 296
 None
 1.29A 5ieoA-4l9mA:
undetectable		 5ieoA-4l9mA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maa PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		5 LEU A 110
LEU A 205
PHE A 178
GLU A 131
ALA A 181
 None
None
GOL  A 503 ( 4.0A)
None
None
 1.35A 5ieoA-4maaA:
undetectable		 5ieoA-4maaA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT

(Bos taurus) 		PF00027
(cNMP_binding) 		5 LEU A 327
LEU A 257
LEU A 254
PHE A 290
ALA A 268
 None
 1.35A 5ieoA-4mx3A:
undetectable		 5ieoA-4mx3A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz0 GENOME POLYPROTEIN

(Cardiovirus A) 		PF00680
(RdRP_1) 		6 LEU A 251
PHE A 255
TYR A  75
LEU A 206
LEU A  83
PHE A 256
 None
 1.41A 5ieoA-4nz0A:
undetectable		 5ieoA-4nz0A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqr CYP105AS1

(Amycolatopsis
orientalis) 		PF00067
(p450) 		5 LEU A 372
LEU A 328
LEU A 330
PHE A 366
PHE A 362
 None
 1.31A 5ieoA-4oqrA:
undetectable		 5ieoA-4oqrA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqs CYP105AS1

(Amycolatopsis
orientalis) 		PF00067
(p450) 		5 LEU A 372
LEU A 328
LEU A 330
PHE A 366
PHE A 362
 None
 1.28A 5ieoA-4oqsA:
undetectable		 5ieoA-4oqsA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B

(Drosophila
melanogaster) 		PF00079
(Serpin) 		5 LEU A  13
PHE A  16
LEU A 281
LEU A  24
ALA A 332
 None
 1.11A 5ieoA-4p0fA:
undetectable		 5ieoA-4p0fA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B

(Drosophila
melanogaster) 		PF00079
(Serpin) 		5 LEU A 112
PHE A 116
LEU A  65
LEU A  63
ALA A  51
 None
 1.39A 5ieoA-4p0fA:
undetectable		 5ieoA-4p0fA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbv NT-3 GROWTH FACTOR
RECEPTOR

(Gallus gallus) 		PF00047
(ig)
PF13855
(LRR_8)
PF16920
(TPKR_C2) 		5 LEU A 152
LEU A 115
LEU A 139
PHE A 147
ALA A 122
 None
 1.00A 5ieoA-4pbvA:
undetectable		 5ieoA-4pbvA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pht GENERAL SECRETORY
PATHWAY PROTEIN E

(Vibrio
vulnificus) 		PF00437
(T2SSE) 		5 PHE A  69
LEU A  37
LEU A  26
PHE A  18
ALA A  47
 None
 1.31A 5ieoA-4phtA:
undetectable		 5ieoA-4phtA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqm URACIL-DNA
GLYCOSYLASE

(Deinococcus
radiodurans) 		PF03167
(UDG) 		5 LEU A  43
LEU A  67
LEU A  23
PHE A  40
ALA A 166
 None
 1.16A 5ieoA-4uqmA:
undetectable		 5ieoA-4uqmA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqm URACIL-DNA
GLYCOSYLASE

(Deinococcus
radiodurans) 		PF03167
(UDG) 		5 LEU A  43
LEU A  67
LEU A  23
PHE A  40
THR A 164
 None
 1.35A 5ieoA-4uqmA:
undetectable		 5ieoA-4uqmA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvq THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE

(Prochloron sp.) 		no annotation 5 PHE A1149
LEU A1078
PHE A1162
THR A1108
ALA A1111
 None
 1.11A 5ieoA-4uvqA:
2.8		 5ieoA-4uvqA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3k UNCHARACTERIZED
PROTEIN PA3435

(Pseudomonas
aeruginosa) 		PF00258
(Flavodoxin_1) 		5 LEU A  78
LEU A  63
LEU A  67
PHE A 111
GLU A 113
 None
 1.22A 5ieoA-5b3kA:
undetectable		 5ieoA-5b3kA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 5 PHE A 157
LEU A 171
TRP A 170
LEU A 209
THR A 277
 None
 1.33A 5ieoA-5b7iA:
undetectable		 5ieoA-5b7iA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza C
virus) 		PF00602
(Flu_PB1)
PF00603
(Flu_PA) 		5 LEU B 238
LEU A 671
LEU A 670
PHE A 642
ALA A 688
 None
 1.34A 5ieoA-5d9aB:
undetectable		 5ieoA-5d9aB:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE

(Escherichia
coli) 		PF02574
(S-methyl_trans) 		5 LEU A 203
LEU A 248
PHE A 195
PHE A 193
ALA A 180
 None
 0.96A 5ieoA-5dmnA:
undetectable		 5ieoA-5dmnA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo6 COPROPORPHYRINOGEN
OXIDASE

(Acinetobacter
baumannii) 		PF01218
(Coprogen_oxidas) 		5 LEU A  58
LEU A 223
LEU A 219
PHE A  40
GLU A  31
 None
 1.29A 5ieoA-5eo6A:
1.4		 5ieoA-5eo6A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Pectobacterium
atrosepticum) 		PF01867
(Cas_Cas1) 		5 TYR A  23
LEU A 298
LEU A 233
PHE A  93
THR A  63
 None
 1.38A 5ieoA-5fclA:
undetectable		 5ieoA-5fclA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foz LARVICIDAL TOXIN
PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		5 LEU B 406
PHE B 423
PHE B 429
GLU B 287
ALA B 364
 None
 1.37A 5ieoA-5fozB:
2.8		 5ieoA-5fozB:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hra ASPARTATE/GLUTAMATE
RACEMASE

(Escherichia
coli) 		PF01177
(Asp_Glu_race) 		5 TYR A  18
LEU A  81
LEU A  64
PHE A  45
THR A 198
 None
None
None
None
DAS  A 301 (-3.2A)
 1.35A 5ieoA-5hraA:
undetectable		 5ieoA-5hraA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvn 3-DEHYDROQUINATE
SYNTHASE

(Francisella
tularensis) 		PF01761
(DHQ_synthase) 		5 LEU A 334
PHE A 332
LEU A 320
LEU A 316
PHE A 278
 None
 1.38A 5ieoA-5hvnA:
undetectable		 5ieoA-5hvnA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5h INNER MEMBRANE
PROTEIN YEJM

(Escherichia
coli) 		PF00884
(Sulfatase)
PF11893
(DUF3413) 		5 LEU A 358
LEU A 494
LEU A 498
PHE A 362
THR A 266
 None
 1.34A 5ieoA-5i5hA:
undetectable		 5ieoA-5i5hA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd9 SPORE COAT PROTEIN H

(Bacillus cereus) 		PF08757
(CotH) 		5 PHE A 299
TYR A 342
PHE A  93
PHE A  94
THR A 250
 None
 1.17A 5ieoA-5jd9A:
undetectable		 5ieoA-5jd9A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans) 		no annotation 5 PHE B 541
TRP B 661
LEU B 669
GLU B 503
ALA B 505
 None
 1.14A 5ieoA-5khnB:
undetectable		 5ieoA-5khnB:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m45 ACETONE CARBOXYLASE
BETA SUBUNIT

(Xanthobacter
autotrophicus) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		5 PHE B 503
TYR B 295
LEU B 300
LEU B 711
PHE B  34
 None
 1.31A 5ieoA-5m45B:
undetectable		 5ieoA-5m45B:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5o RNASE ADAPTER
PROTEIN RAPZ

(Escherichia
coli) 		PF03668
(ATP_bind_2) 		5 LEU A 261
PHE A 265
LEU A 233
LEU A 160
PHE A 164
 None
 1.26A 5ieoA-5o5oA:
undetectable		 5ieoA-5o5oA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5s RNASE ADAPTER
PROTEIN RAPZ

(Escherichia
coli) 		PF03668
(ATP_bind_2) 		5 LEU A 261
PHE A 265
LEU A 233
LEU A 160
PHE A 164
 None
 1.32A 5ieoA-5o5sA:
undetectable		 5ieoA-5o5sA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of2 SPORE
COAT-ASSOCIATED
PROTEIN N

(Bacillus
subtilis) 		no annotation 5 LEU A  46
LEU A 113
PHE A  72
PHE A  70
ALA A  53
 None
 1.24A 5ieoA-5of2A:
undetectable		 5ieoA-5of2A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uto EDD DOMAIN PROTEIN,
DEGV FAMILY

(Staphylococcus
aureus) 		no annotation 5 LEU A 168
PHE A 263
GLU A  40
THR A  10
ALA A 122
 None
PLM  A 301 ( 4.8A)
None
None
PLM  A 301 ( 4.5A)
 1.23A 5ieoA-5utoA:
undetectable		 5ieoA-5utoA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36

(Bos taurus) 		no annotation 5 LEU A 807
PHE A 812
LEU A 955
LEU A 982
ALA A 839
 None
 1.25A 5ieoA-5vhaA:
undetectable		 5ieoA-5vhaA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxg -

(-) 		no annotation 5 LEU A  36
PHE A 126
LEU A 171
LEU A 165
PHE A 110
 None
 1.28A 5ieoA-5xxgA:
undetectable		 5ieoA-5xxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A  38
PHE A 129
LEU A 115
LEU A 111
PHE A  82
 None
 1.28A 5ieoA-5y58A:
2.2		 5ieoA-5y58A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axf RAS GUANYL-RELEASING
PROTEIN 2

(Homo sapiens) 		no annotation 5 LEU A 368
TRP A 206
LEU A 364
PHE A 227
ALA A 245
 None
 1.05A 5ieoA-6axfA:
undetectable		 5ieoA-6axfA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axg RAS GUANYL-RELEASING
PROTEIN 4

(Homo sapiens) 		no annotation 5 LEU A 413
TRP A 253
LEU A 409
PHE A 274
ALA A 292
 None
 1.06A 5ieoA-6axgA:
undetectable		 5ieoA-6axgA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6

(Homo sapiens;
Mus musculus) 		no annotation 5 LEU A 105
LEU A 158
LEU A 153
PHE A 134
ALA A 171
 None
 1.31A 5ieoA-6bbpA:
undetectable		 5ieoA-6bbpA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2i PROTEIN (RESTRICTION
ENDONUCLEASE BGLII)

(Bacillus
subtilis) 		PF09195
(Endonuc-BglII) 		4 MET A 117
LEU A  91
ILE A  83
LEU A 152
 None
 0.91A 5ieoA-1d2iA:
undetectable		 5ieoA-1d2iA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbn PROTEIN
(LEUKOAGGLUTININ)

(Maackia
amurensis) 		PF00139
(Lectin_legB) 		4 ILE A 173
LEU A 207
ILE A 206
TYR A  92
 None
 1.00A 5ieoA-1dbnA:
0.0		 5ieoA-1dbnA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF02463
(SMC_N) 		4 ILE A 139
LEU A1037
ILE A1034
LEU A1103
 None
 0.97A 5ieoA-1e69A:
0.2		 5ieoA-1e69A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 156
PRO A 154
LEU A 189
LEU A 343
 None
 0.86A 5ieoA-1gngA:
0.0		 5ieoA-1gngA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00266
(Aminotran_5) 		4 ILE A 348
PRO A 290
LEU A 323
TYR A 295
 None
 0.97A 5ieoA-1iugA:
0.0		 5ieoA-1iugA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlf LAC REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		4 ILE A 257
MET A 232
LEU A 174
ILE A 182
 None
 0.99A 5ieoA-1tlfA:
undetectable		 5ieoA-1tlfA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up4 6-PHOSPHO-BETA-GLUCO
SIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 ILE A 166
PRO A 165
ILE A 159
TYR A 294
 None
 0.94A 5ieoA-1up4A:
0.0		 5ieoA-1up4A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v77 HYPOTHETICAL PROTEIN
PH1877

(Pyrococcus
horikoshii) 		PF01876
(RNase_P_p30) 		4 ILE A 101
MET A 190
LEU A 181
ILE A 199
 None
 0.94A 5ieoA-1v77A:
0.0		 5ieoA-1v77A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE

(Thermotoga
maritima) 		PF02547
(Queuosine_synth) 		4 PRO A 277
LEU A 287
ILE A 334
LEU A 273
 None
 0.84A 5ieoA-1vkyA:
undetectable		 5ieoA-1vkyA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp8 HYPOTHETICAL PROTEIN
AF0103

(Archaeoglobus
fulgidus) 		PF02887
(PK_C) 		4 ILE A 165
PRO A 167
LEU A  96
ILE A  95
 None
 0.99A 5ieoA-1vp8A:
undetectable		 5ieoA-1vp8A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 ILE A 117
LEU A 307
ILE A 304
LEU A 143
 None
 0.98A 5ieoA-1x8vA:
undetectable		 5ieoA-1x8vA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zov MONOMERIC SARCOSINE
OXIDASE

(Bacillus sp.
NS-129) 		PF01266
(DAO) 		4 PRO A  38
LEU A  75
ILE A  83
LEU A  31
 None
 0.90A 5ieoA-1zovA:
undetectable		 5ieoA-1zovA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Saccharomyces
cerevisiae) 		PF00579
(tRNA-synt_1b) 		4 PRO X 275
LEU X 109
ILE X 108
LEU X  15
 None
 0.97A 5ieoA-2dlcX:
undetectable		 5ieoA-2dlcX:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dmm PROTEIN
DISULFIDE-ISOMERASE
A3

(Homo sapiens) 		PF00085
(Thioredoxin) 		4 ILE A 104
LEU A  74
ILE A  80
LEU A  63
 None
 0.96A 5ieoA-2dmmA:
undetectable		 5ieoA-2dmmA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f28 SIALIDASE 2

(Homo sapiens) 		PF13088
(BNR_2) 		4 LEU A 337
ILE A 277
TYR A 310
LEU A 326
 None
 0.96A 5ieoA-2f28A:
2.3		 5ieoA-2f28A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHL

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox) 		4 MET C 268
ILE C 286
TYR C 294
LEU C 229
 None
 0.97A 5ieoA-2inpC:
undetectable		 5ieoA-2inpC:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF01380
(SIS)
PF13522
(GATase_6) 		4 PRO A 565
LEU A 582
ILE A 454
LEU A 440
 None
 0.98A 5ieoA-2j6hA:
undetectable		 5ieoA-2j6hA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780

(Pyrococcus
abyssi) 		PF05958
(tRNA_U5-meth_tr) 		4 ILE A 209
LEU A 172
ILE A 115
TYR A 203
 None
 0.94A 5ieoA-2jjqA:
undetectable		 5ieoA-2jjqA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ILE A 769
PRO A 770
ILE A 749
LEU A 693
 None
 0.97A 5ieoA-2pffA:
undetectable		 5ieoA-2pffA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6i COLLAGENASE

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		4 ILE A 472
LEU A 468
TYR A 504
LEU A 411
 None
 1.01A 5ieoA-2y6iA:
undetectable		 5ieoA-2y6iA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN

(Escherichia
coli) 		PF06751
(EutB) 		4 ILE A 436
LEU A 161
ILE A 190
LEU A 442
 None
 0.84A 5ieoA-3anyA:
undetectable		 5ieoA-3anyA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8b CYSQ, SULFITE
SYNTHESIS PATHWAY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00459
(Inositol_P) 		4 ILE A  14
PRO A 116
ILE A 100
LEU A  36
 None
 1.00A 5ieoA-3b8bA:
undetectable		 5ieoA-3b8bA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2g SYS-1 PROTEIN

(Caenorhabditis
elegans) 		no annotation 4 ILE A 326
LEU A 234
ILE A 237
LEU A 335
 None
 0.99A 5ieoA-3c2gA:
undetectable		 5ieoA-3c2gA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cue TRANSPORT PROTEIN
PARTICLE 23 KDA
SUBUNIT
TRANSPORT PROTEIN
PARTICLE 31 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF04051
(TRAPP)
PF04099
(Sybindin) 		4 ILE B 222
PRO A 194
LEU B  59
TYR A 189
 None
 0.73A 5ieoA-3cueB:
undetectable		 5ieoA-3cueB:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Burkholderia
pseudomallei) 		PF14681
(UPRTase) 		4 ILE A  80
LEU A  54
ILE A  73
LEU A 164
 None
 0.89A 5ieoA-3dmpA:
undetectable		 5ieoA-3dmpA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doa FIBRINOGEN BINDING
PROTEIN

(Staphylococcus
aureus) 		PF05833
(FbpA) 		4 ILE A 121
MET A  36
LEU A  15
ILE A  90
 None
 0.96A 5ieoA-3doaA:
1.7		 5ieoA-3doaA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ele AMINO TRANSFERASE

([Eubacterium]
rectale) 		PF00155
(Aminotran_1_2) 		4 ILE A 391
LEU A 315
ILE A 381
LEU A 340
 None
 0.90A 5ieoA-3eleA:
undetectable		 5ieoA-3eleA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg2 PUTATIVE RUBREDOXIN
REDUCTASE

(Rhodopseudomonas
palustris) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		4 ILE P   6
MET P  79
ILE P 257
LEU P  20
 None
FAD  P 449 (-4.5A)
None
None
 0.90A 5ieoA-3fg2P:
undetectable		 5ieoA-3fg2P:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glg DNA POLYMERASE III
SUBUNIT DELTA'

(Escherichia
coli) 		PF09115
(DNApol3-delta_C)
PF13177
(DNA_pol3_delta2) 		4 ILE E 289
LEU E 236
ILE E 312
LEU E 277
 None
 0.99A 5ieoA-3glgE:
undetectable		 5ieoA-3glgE:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Escherichia
coli) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 ILE A  99
PRO A  98
MET A 188
ILE A  91
 None
 0.86A 5ieoA-3gmeA:
undetectable		 5ieoA-3gmeA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqc DNA REPAIR PROTEIN
REV1

(Homo sapiens) 		PF00817
(IMS)
PF11799
(IMS_C) 		4 ILE A 564
MET A 420
ILE A 598
LEU A 375
 None
 1.01A 5ieoA-3gqcA:
undetectable		 5ieoA-3gqcA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlz UNCHARACTERIZED
PROTEIN BT_1490

(Bacteroides
thetaiotaomicron) 		PF12712
(DUF3805)
PF12713
(DUF3806) 		4 ILE A 239
PRO A 241
LEU A 179
ILE A 182
 ACT  A 273 (-4.9A)
None
None
None
 0.99A 5ieoA-3hlzA:
undetectable		 5ieoA-3hlzA:
20.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hx8 PUTATIVE KETOSTEROID
ISOMERASE

(Mesorhizobium
loti) 		PF14534
(DUF4440) 		4 PRO A  60
MET A  63
ILE A  84
LEU A 139
 None
UNL  A 200 ( 4.3A)
None
None
 0.94A 5ieoA-3hx8A:
20.1		 5ieoA-3hx8A:
82.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE

(Aspergillus
fumigatus) 		PF11991
(Trp_DMAT) 		4 ILE A 232
PRO A 243
LEU A 333
ILE A 258
 None
 0.84A 5ieoA-3i4xA:
0.4		 5ieoA-3i4xA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Rattus
norvegicus) 		PF00520
(Ion_trans)
PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08454
(RIH_assoc)
PF08709
(Ins145_P3_rec) 		4 ILE A 432
PRO A 434
MET A 224
LEU A 242
 None
 1.02A 5ieoA-3javA:
undetectable		 5ieoA-3javA:
4.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3knz PUTATIVE SUGAR
BINDING PROTEIN

(Salmonella
enterica) 		PF01380
(SIS) 		4 ILE A 320
MET A 226
LEU A 295
ILE A 284
 None
 0.91A 5ieoA-3knzA:
undetectable		 5ieoA-3knzA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lod PUTATIVE ACYL-COA
N-ACYLTRANSFERASE

(Klebsiella
pneumoniae) 		PF00583
(Acetyltransf_1) 		4 ILE A  18
LEU A  93
ILE A  52
LEU A  39
 None
 1.01A 5ieoA-3lodA:
undetectable		 5ieoA-3lodA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0o MONOMERIC SARCOSINE
OXIDASE

(Bacillus sp.
B-0618) 		PF01266
(DAO) 		4 PRO A  38
LEU A  75
ILE A  83
LEU A  31
 None
 0.90A 5ieoA-3m0oA:
undetectable		 5ieoA-3m0oA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p19 PUTATIVE BLUE
FLUORESCENT PROTEIN

(Vibrio
vulnificus) 		PF00106
(adh_short) 		4 ILE A 130
PRO A 175
ILE A 227
LEU A 108
 NDP  A2001 ( 4.6A)
NDP  A2001 ( 4.0A)
None
None
 0.94A 5ieoA-3p19A:
undetectable		 5ieoA-3p19A:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rw7 NUCLEAR RNA EXPORT
FACTOR 1

(Homo sapiens) 		PF09162
(Tap-RNA_bind) 		4 ILE A 260
MET A 253
LEU A 315
ILE A 312
 None
 0.96A 5ieoA-3rw7A:
undetectable		 5ieoA-3rw7A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG

(Mus musculus) 		PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2) 		4 ILE A 456
MET A 390
ILE A 466
LEU A 490
 None
 0.96A 5ieoA-3s51A:
undetectable		 5ieoA-3s51A:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slc ACETATE KINASE

(Salmonella
enterica) 		PF00871
(Acetate_kinase) 		4 ILE A 372
MET A 303
LEU A 211
ILE A 334
 None
 0.92A 5ieoA-3slcA:
undetectable		 5ieoA-3slcA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zil AAR187CP

(Eremothecium
gossypii) 		PF16997
(Wap1) 		4 ILE A 277
LEU A 211
ILE A 210
LEU A 279
 None
 0.86A 5ieoA-3zilA:
undetectable		 5ieoA-3zilA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apl APICAL MEMBRANE
ANTIGEN 1

(Neospora
caninum) 		PF02430
(AMA-1) 		4 PRO A 210
ILE A 136
TYR A 221
LEU A 262
 None
 0.90A 5ieoA-4aplA:
undetectable		 5ieoA-4aplA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9b PRE-MRNA-SPLICING
FACTOR CWC22 HOMOLOG

(Homo sapiens) 		PF02854
(MIF4G) 		4 ILE B 233
LEU B 185
ILE B 182
TYR B 215
 None
 0.99A 5ieoA-4c9bB:
undetectable		 5ieoA-4c9bB:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 ILE A 818
PRO A 820
TYR A 784
LEU A 803
 None
 0.90A 5ieoA-4cakA:
0.4		 5ieoA-4cakA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7u ENDOGLUCANASE II

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		4 ILE A 219
PRO A  86
ILE A 167
LEU A 224
 None
 0.99A 5ieoA-4d7uA:
undetectable		 5ieoA-4d7uA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		4 ILE A  55
PRO A  52
ILE A  91
LEU A 323
 None
3PY  A 404 (-3.9A)
None
None
 1.01A 5ieoA-4dqdA:
undetectable		 5ieoA-4dqdA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4en2 AP-1 COMPLEX SUBUNIT
MU-1

(Mus musculus) 		no annotation 4 ILE M 397
PRO M 407
LEU M 264
ILE M 198
 None
 0.83A 5ieoA-4en2M:
undetectable		 5ieoA-4en2M:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hku TETR TRANSCRIPTIONAL
REGULATOR

(Listeria
monocytogenes) 		PF00440
(TetR_N) 		4 ILE A 111
LEU A 125
ILE A 143
LEU A  57
 None
 0.92A 5ieoA-4hkuA:
undetectable		 5ieoA-4hkuA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn9 IRON COMPLEX
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN

([Eubacterium]
eligens) 		PF01497
(Peripla_BP_2) 		4 ILE A 181
PRO A  72
MET A 121
ILE A 158
 None
 0.84A 5ieoA-4hn9A:
undetectable		 5ieoA-4hn9A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iru LEPB

(Legionella
pneumophila) 		no annotation 4 ILE A 349
MET A 355
LEU A 481
ILE A 484
 None
 0.93A 5ieoA-4iruA:
undetectable		 5ieoA-4iruA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9g TRANSCRIPTIONAL
REGULATOR, PPSR

(Rhodobacter
sphaeroides) 		PF13188
(PAS_8) 		4 ILE A 113
ILE A  19
TYR A 102
LEU A  58
 None
 0.92A 5ieoA-4l9gA:
undetectable		 5ieoA-4l9gA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3
GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		4 ILE B 521
ILE A 528
TYR B 479
LEU B 499
 None
EDO  B 701 (-4.4A)
None
None
 0.91A 5ieoA-4ni2B:
undetectable		 5ieoA-4ni2B:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obm UNCHARACTERIZED
PROTEIN

([Eubacterium]
siraeum) 		no annotation 4 ILE A  66
MET A 133
LEU A 211
TYR A  68
 None
 1.03A 5ieoA-4obmA:
undetectable		 5ieoA-4obmA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 MET B 386
LEU B 366
ILE B 278
TYR B 252
 None
 0.87A 5ieoA-4pe5B:
undetectable		 5ieoA-4pe5B:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4puf E3 UBIQUITIN-PROTEIN
LIGASE SLRP

(Salmonella
enterica) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		4 ILE A 243
PRO A 240
ILE A 193
LEU A 267
 None
 0.83A 5ieoA-4pufA:
undetectable		 5ieoA-4pufA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4puf E3 UBIQUITIN-PROTEIN
LIGASE SLRP

(Salmonella
enterica) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		4 ILE A 243
PRO A 240
MET A 172
ILE A 193
 None
 0.99A 5ieoA-4pufA:
undetectable		 5ieoA-4pufA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2h PROLINE RACEMASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF05544
(Pro_racemase) 		4 ILE A 304
PRO A 306
MET A 229
ILE A 239
 None
None
CSO  A 255 ( 4.0A)
GOL  A 402 ( 4.8A)
 0.99A 5ieoA-4q2hA:
undetectable		 5ieoA-4q2hA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roa SERPIN 2

(Anopheles
gambiae) 		PF00079
(Serpin) 		4 PRO A  57
MET A 398
LEU A 273
ILE A 276
 None
 0.98A 5ieoA-4roaA:
1.4		 5ieoA-4roaA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1t URIDYLATE-SPECIFIC
ENDORIBONUCLEASE

(Human
coronavirus
229E) 		PF06471
(NSP11) 		4 ILE A 253
LEU A 228
ILE A 223
LEU A 300
 None
 0.87A 5ieoA-4s1tA:
undetectable		 5ieoA-4s1tA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0t ADC-7 BETA-LACTAMASE

(Acinetobacter
baumannii) 		PF00144
(Beta-lactamase) 		4 ILE A 155
MET A 166
LEU A 174
ILE A 178
 None
 0.90A 5ieoA-4u0tA:
undetectable		 5ieoA-4u0tA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3

(Mus musculus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 ILE A 177
PRO A 174
ILE A 119
LEU A 204
 None
 0.76A 5ieoA-4v2eA:
undetectable		 5ieoA-4v2eA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3

(Mus musculus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 ILE A 177
PRO A 174
ILE A 145
LEU A 204
 None
 0.90A 5ieoA-4v2eA:
undetectable		 5ieoA-4v2eA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yco TRNA-DIHYDROURIDINE
SYNTHASE C

(Escherichia
coli) 		PF01207
(Dus) 		4 ILE A 119
LEU A 193
ILE A 195
LEU A 113
 None
 0.96A 5ieoA-4ycoA:
undetectable		 5ieoA-4ycoA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrq TRANSCOBALAMIN-2

(Homo sapiens) 		PF01122
(Cobalamin_bind)
PF14478
(DUF4430) 		4 PRO A 276
MET A  24
LEU A 298
LEU A 260
 None
 0.95A 5ieoA-4zrqA:
undetectable		 5ieoA-4zrqA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE

(Escherichia
coli) 		PF01790
(LGT) 		4 ILE A 271
MET A 278
ILE A 213
TYR A 235
 PGT  A 311 ( 4.1A)
PGT  A 307 (-4.0A)
None
PLM  A 301 (-4.7A)
 0.87A 5ieoA-5azbA:
undetectable		 5ieoA-5azbA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es6 LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00551
(Formyl_trans_N) 		4 ILE A 100
LEU A  21
ILE A   4
TYR A  51
 None
 0.84A 5ieoA-5es6A:
undetectable		 5ieoA-5es6A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00551
(Formyl_trans_N)
PF13193
(AMP-binding_C) 		4 ILE A 100
LEU A  21
ILE A   4
TYR A  51
 None
 0.87A 5ieoA-5es9A:
undetectable		 5ieoA-5es9A:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby SEPARASE

(Chaetomium
thermophilum) 		PF03568
(Peptidase_C50) 		4 ILE A1815
LEU A1957
ILE A1717
LEU A1771
 None
 0.98A 5ieoA-5fbyA:
undetectable		 5ieoA-5fbyA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsy MACRODOMAIN

(Trypanosoma
brucei) 		PF01661
(Macro) 		4 PRO A  91
LEU A 233
ILE A  98
LEU A 114
 None
 0.99A 5ieoA-5fsyA:
undetectable		 5ieoA-5fsyA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsz MACRODOMAIN

(Trypanosoma
cruzi) 		PF01661
(Macro) 		4 PRO A  84
LEU A 226
ILE A  91
LEU A 107
 None
 0.97A 5ieoA-5fszA:
undetectable		 5ieoA-5fszA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hg0 PANTOTHENATE
SYNTHETASE

(Francisella
tularensis) 		PF02569
(Pantoate_ligase) 		4 ILE A 171
LEU A 136
ILE A 166
LEU A  39
 None
None
None
SAM  A 301 ( 4.8A)
 1.00A 5ieoA-5hg0A:
undetectable		 5ieoA-5hg0A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7z PUTATIVE SECRETED
ENDOGLYCOSYLCERAMIDA
SE

(Rhodococcus
hoagii) 		PF00150
(Cellulase) 		4 MET A 124
ILE A  79
TYR A 364
LEU A 352
 None
 0.96A 5ieoA-5j7zA:
undetectable		 5ieoA-5j7zA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jdx PUTATIVE PEPTIDYL
CARRIER PROTEIN

(Serratia sp.) 		no annotation 4 PRO A  61
LEU A  22
ILE A  33
LEU A  46
 None
 0.84A 5ieoA-5jdxA:
undetectable		 5ieoA-5jdxA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jir OOP FAMILY OMPA-OMPF
PORIN

(Treponema
pallidum) 		no annotation 4 ILE B 289
MET B 241
ILE B 298
LEU B 209
 None
 0.97A 5ieoA-5jirB:
undetectable		 5ieoA-5jirB:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		no annotation 4 ILE C 100
LEU C  21
ILE C   4
TYR C  51
 None
 0.84A 5ieoA-5jnfC:
undetectable		 5ieoA-5jnfC:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2d SURFACE-ASSOCIATED
PROTEIN CSHA

(Streptococcus
gordonii) 		no annotation 4 ILE A 154
PRO A 227
MET A 181
ILE A 199
 None
 0.97A 5ieoA-5l2dA:
undetectable		 5ieoA-5l2dA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 ILE B 640
PRO B 642
LEU B 686
LEU B 638
 None
 0.86A 5ieoA-5ldrB:
undetectable		 5ieoA-5ldrB:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2b PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5

(Homo sapiens;
Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		4 MET K  86
LEU K  41
ILE K  37
TYR K  66
 None
 0.85A 5ieoA-5m2bK:
undetectable		 5ieoA-5m2bK:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu4 TAIL TUBULAR PROTEIN
A

(Klebsiella
virus KP32) 		PF17212
(Tube) 		4 ILE A 134
LEU A  85
ILE A 118
LEU A  47
 None
 0.93A 5ieoA-5mu4A:
undetectable		 5ieoA-5mu4A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng5 MULTIDRUG EFFLUX
PUMP SUBUNIT ACRA

(Escherichia
coli) 		no annotation 4 ILE E 361
LEU E 353
ILE E 306
LEU E 364
 None
 0.92A 5ieoA-5ng5E:
undetectable		 5ieoA-5ng5E:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmi CYTOCHROME C1, HEME
PROTEIN,
MITOCHONDRIAL

(Bos taurus) 		PF02167
(Cytochrom_C1) 		4 ILE D 164
LEU D 113
ILE D 116
LEU D 169
 None
HEC  D 501 ( 4.9A)
HEC  D 501 (-4.3A)
None
 0.90A 5ieoA-5nmiD:
undetectable		 5ieoA-5nmiD:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nny WIPB

(Legionella
pneumophila) 		no annotation 4 ILE A 146
LEU A  44
ILE A  49
LEU A 120
 None
 0.75A 5ieoA-5nnyA:
undetectable		 5ieoA-5nnyA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1

(Saccharomyces
cerevisiae) 		PF12231
(Rif1_N) 		4 ILE A 476
PRO A 425
ILE A 433
LEU A 494
 None
 0.91A 5ieoA-5nvrA:
undetectable		 5ieoA-5nvrA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ode GLL2934 PROTEIN

(Gloeobacter
violaceus) 		no annotation 4 ILE A 187
MET A 159
ILE A 245
LEU A 205
 None
 0.99A 5ieoA-5odeA:
undetectable		 5ieoA-5odeA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oik TRANSCRIPTION
ELONGATION FACTOR
SPT4
TRANSCRIPTION
ELONGATION FACTOR
SPT5

(Homo sapiens) 		PF00467
(KOW)
PF03439
(Spt5-NGN)
PF06093
(Spt4) 		4 MET Y  64
LEU Z 245
ILE Z 239
LEU Y  10
 None
 0.84A 5ieoA-5oikY:
undetectable		 5ieoA-5oikY:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okd CYTOCHROME C1, HEME
PROTEIN,
MITOCHONDRIAL

(Bos taurus) 		no annotation 4 ILE D 164
LEU D 113
ILE D 116
LEU D 169
 None
None
HEC  D 501 (-4.2A)
None
 0.88A 5ieoA-5okdD:
undetectable		 5ieoA-5okdD:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 ILE A 232
LEU A 268
ILE A 264
LEU A 234
 None
 0.72A 5ieoA-5thhA:
undetectable		 5ieoA-5thhA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thx FERREDOXIN--NADP
REDUCTASE

(Neisseria
gonorrhoeae) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 ILE A 119
LEU A 174
ILE A 138
LEU A 150
 None
 0.88A 5ieoA-5thxA:
undetectable		 5ieoA-5thxA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 KLOTHO

(Homo sapiens) 		no annotation 4 ILE A 871
LEU A 856
ILE A 907
TYR A 912
 None
 0.93A 5ieoA-5w21A:
undetectable		 5ieoA-5w21A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2o TASTE RECEPTOR, TYPE
1, MEMBER 3

(Oryzias latipes) 		PF01094
(ANF_receptor) 		4 ILE B  46
PRO B  45
ILE B 145
TYR B 103
 None
CL  B 971 ( 4.0A)
None
None
 0.88A 5ieoA-5x2oB:
undetectable		 5ieoA-5x2oB:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd0 GLUCANASE

(Paenibacillus
sp. X4) 		PF01270
(Glyco_hydro_8) 		4 ILE A 250
MET A 192
LEU A 228
LEU A 265
 None
 0.99A 5ieoA-5xd0A:
undetectable		 5ieoA-5xd0A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a8m -

(-) 		no annotation 4 ILE A 308
MET A 196
LEU A 218
ILE A 262
 None
 1.01A 5ieoA-6a8mA:
1.8		 5ieoA-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bn2 ACETYL-COA
ACETYLTRANSFERASE

(Elizabethkingia
anophelis) 		no annotation 4 ILE A  41
MET A  53
LEU A  75
LEU A 267
 None
 0.84A 5ieoA-6bn2A:
undetectable		 5ieoA-6bn2A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj POLYADENYLATION
FACTOR SUBUNIT
2,POLYADENYLATION
FACTOR SUBUNIT 2

(Saccharomyces
cerevisiae) 		no annotation 4 ILE D 364
LEU D 329
ILE D 345
LEU D 108
 None
 0.93A 5ieoA-6eojD:
2.5		 5ieoA-6eojD:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eq8 PERIPLASMIC
ALPHA-GALACTOSIDE-BI
NDING PROTEIN

(Agrobacterium
tumefaciens) 		no annotation 4 ILE D 408
LEU D 481
TYR D 365
LEU D 412
 None
 0.89A 5ieoA-6eq8D:
undetectable		 5ieoA-6eq8D:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 4 ILE A 465
PRO A 462
ILE A 456
LEU A 495
 None
 0.83A 5ieoA-6fnwA:
undetectable		 5ieoA-6fnwA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 4 MET A 590
LEU A 551
ILE A 574
LEU A 518
 None
 1.03A 5ieoA-6g9oA:
undetectable		 5ieoA-6g9oA:
20.90