SIMILAR PATTERNS OF AMINO ACIDS FOR 5IEN_B_VDYB201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exb KV BETA2 PROTEIN

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		5 LEU A 340
LEU A 303
LEU A 343
ILE A 354
LEU A 355
 None
 1.04A 5ienB-1exbA:
undetectable		 5ienB-1exbA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gmi PROTEIN KINASE C,
EPSILON TYPE

(Rattus rattus) 		PF00168
(C2) 		5 LEU A  38
TRP A  65
LEU A  18
ILE A 117
ALA A  82
 None
 1.22A 5ienB-1gmiA:
0.0		 5ienB-1gmiA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		5 LEU A 499
LEU A 601
LEU A 500
THR A 568
ALA A 564
 None
 1.07A 5ienB-1kehA:
undetectable		 5ienB-1kehA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpc DIANTHIN 30

(Dianthus
caryophyllus) 		PF00161
(RIP) 		5 LEU A   8
PHE A  56
LEU A  67
LEU A   6
ALA A 178
 None
 1.21A 5ienB-1lpcA:
undetectable		 5ienB-1lpcA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p50 ARGININE KINASE

(Limulus
polyphemus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 LEU A 110
MET A 352
LEU A 239
ILE A 325
LEU A 306
 None
 1.20A 5ienB-1p50A:
0.0		 5ienB-1p50A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyf IOLS PROTEIN

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		5 LEU A 180
LEU A 276
ILE A 262
ALA A 269
LEU A 297
 None
 1.22A 5ienB-1pyfA:
0.0		 5ienB-1pyfA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 95 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08519
(RFC1) 		5 TRP A 323
LEU A 324
LEU A 453
ILE A 374
THR A 447
 None
 1.20A 5ienB-1sxjA:
0.0		 5ienB-1sxjA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2a GLUTATHIONE
TRANSFERASE GST1-6

(Anopheles dirus) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 LEU A  17
TRP A 180
LEU A 135
ILE A 107
LEU A 164
 None
 1.15A 5ienB-1v2aA:
0.0		 5ienB-1v2aA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqr HYPOTHETICAL PROTEIN
CJ0248

(Campylobacter
jejuni) 		PF08668
(HDOD) 		5 LEU A 114
LEU A  19
ILE A  86
ALA A  54
LEU A  56
 None
 1.24A 5ienB-1vqrA:
undetectable		 5ienB-1vqrA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp4 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Streptococcus
pneumoniae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 LEU A  90
ILE A  99
GLU A 135
THR A 159
ALA A 124
 None
 1.22A 5ienB-1xp4A:
undetectable		 5ienB-1xp4A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl0 HYPOTHETICAL PROTEIN
PA5198

(Pseudomonas
aeruginosa) 		PF02016
(Peptidase_S66) 		5 LEU A 196
LEU A  98
TYR A 294
ALA A 131
LEU A 129
 None
 1.11A 5ienB-1zl0A:
undetectable		 5ienB-1zl0A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		6 LEU A 461
PHE A 458
LEU A 468
ILE A 379
ALA A 531
LEU A 528
 None
 1.48A 5ienB-2ag1A:
undetectable		 5ienB-2ag1A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		5 LEU A 135
ILE A 120
TYR A 179
ALA A 173
LEU A 171
 None
 1.13A 5ienB-2azkA:
undetectable		 5ienB-2azkA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdq ASPARTOKINASE

(Arabidopsis
thaliana) 		PF00696
(AA_kinase) 		5 LEU A 119
ILE A 211
THR A  69
ALA A  65
LEU A  63
 None
None
None
LYS  A 601 (-3.9A)
None
 1.15A 5ienB-2cdqA:
undetectable		 5ienB-2cdqA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfi PHYTASE

(Debaryomyces
castellii) 		PF00328
(His_Phos_2) 		5 LEU A 248
ILE A 277
TYR A  90
GLU A  91
LEU A 258
 None
 1.24A 5ienB-2gfiA:
0.0		 5ienB-2gfiA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 361
MET A 359
LEU A 242
ALA A 371
LEU A 399
 None
 1.02A 5ienB-2gpvA:
undetectable		 5ienB-2gpvA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 LEU A 300
LEU A 274
LEU A 296
ILE A 435
ALA A 407
 None
 1.15A 5ienB-2h2qA:
undetectable		 5ienB-2h2qA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8i NP275

(Nostoc
punctiforme) 		PF00805
(Pentapeptide) 		5 LEU A  82
MET A   1
ILE A  30
ALA A  55
LEU A  32
 None
 0.95A 5ienB-2j8iA:
undetectable		 5ienB-2j8iA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8k NP275-NP276

(Nostoc
punctiforme) 		PF00805
(Pentapeptide) 		5 LEU A  82
MET A   1
ILE A  30
ALA A  55
LEU A  32
 None
 0.89A 5ienB-2j8kA:
undetectable		 5ienB-2j8kA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8k NP275-NP276

(Nostoc
punctiforme) 		PF00805
(Pentapeptide) 		6 LEU A  87
MET A   1
LEU A  67
ILE A  30
ALA A  55
LEU A  32
 None
 1.49A 5ienB-2j8kA:
undetectable		 5ienB-2j8kA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyz HYPOTHETICAL PROTEIN
GAMMAHV.M3

(Murid
gammaherpesvirus
4) 		PF09213
(M3) 		5 LEU A  55
ILE A  26
GLU A 197
THR A 183
LEU A  65
 None
 1.03A 5ienB-2nyzA:
undetectable		 5ienB-2nyzA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1e YCDH

(Bacillus
subtilis) 		PF01297
(ZnuA) 		5 LEU A 131
LEU A 291
ILE A 283
TYR A 239
THR A 190
 None
 0.88A 5ienB-2o1eA:
undetectable		 5ienB-2o1eA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1e YCDH

(Bacillus
subtilis) 		PF01297
(ZnuA) 		5 LEU A 295
LEU A 131
LEU A 291
ILE A 283
TYR A 239
 None
 1.20A 5ienB-2o1eA:
undetectable		 5ienB-2o1eA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN

(Cyanothece) 		PF00805
(Pentapeptide) 		6 LEU A  97
LEU A 117
ILE A 165
THR A 110
ALA A 130
LEU A 147
 None
 0.99A 5ienB-2o6wA:
undetectable		 5ienB-2o6wA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		5 LEU A  31
LEU A 149
ILE A 186
ALA A 271
LEU A 267
 GRG  A 500 (-4.3A)
None
None
None
None
 1.11A 5ienB-2q80A:
undetectable		 5ienB-2q80A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN

(Bacillus cereus) 		PF05139
(Erythro_esteras) 		5 LEU A 426
LEU A  79
MET A 302
ILE A  71
LEU A  67
 None
 1.15A 5ienB-2qgmA:
undetectable		 5ienB-2qgmA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qza SECRETED EFFECTOR
PROTEIN

(Salmonella
enterica) 		PF13599
(Pentapeptide_4)
PF13979
(SopA_C)
PF13981
(SopA) 		5 LEU A 273
LEU A 241
LEU A 253
ILE A 205
THR A 279
 None
 1.22A 5ienB-2qzaA:
undetectable		 5ienB-2qzaA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w87 ESTERASE D

(Cellvibrio
japonicus) 		PF03422
(CBM_6) 		5 ILE A  65
GLU A 126
THR A 124
ALA A 122
LEU A 120
 None
 1.20A 5ienB-2w87A:
undetectable		 5ienB-2w87A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		5 LEU A 806
LEU A 830
THR A 820
ALA A 844
LEU A 870
 None
 1.17A 5ienB-2wfhA:
undetectable		 5ienB-2wfhA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpa UNCHARACTERIZED
PROTEIN YPFI

(Escherichia
coli) 		PF05127
(Helicase_RecD)
PF08351
(DUF1726)
PF13718
(GNAT_acetyltr_2)
PF17176
(tRNA_bind_3) 		5 LEU A 500
PHE A 503
LEU A 476
ALA A 376
LEU A 373
 ACO  A 700 ( 4.6A)
ACO  A 700 (-3.8A)
None
ACO  A 700 ( 4.5A)
None
 1.24A 5ienB-2zpaA:
undetectable		 5ienB-2zpaA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwn L-TRYPTOPHAN
AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF04864
(Alliinase_C) 		5 LEU A 212
LEU A  65
LEU A 103
ILE A 245
ALA A 110
 None
 0.90A 5ienB-3bwnA:
undetectable		 5ienB-3bwnA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzm MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Escherichia
coli) 		PF00425
(Chorismate_bind) 		5 LEU A  83
PHE A  82
LEU A  92
ILE A  28
LEU A 125
 None
 1.21A 5ienB-3bzmA:
undetectable		 5ienB-3bzmA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du1 ALL3740 PROTEIN

(Nostoc sp. PCC
7120) 		PF00805
(Pentapeptide) 		5 LEU X  42
LEU X  62
THR X  55
ALA X  75
LEU X  92
 None
 1.15A 5ienB-3du1X:
undetectable		 5ienB-3du1X:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du1 ALL3740 PROTEIN

(Nostoc sp. PCC
7120) 		PF00805
(Pentapeptide) 		5 LEU X  82
LEU X 102
THR X  95
ALA X 115
LEU X 137
 None
 1.00A 5ienB-3du1X:
undetectable		 5ienB-3du1X:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1s EXODEOXYRIBONUCLEASE
V, SUBUNIT RECD

(Deinococcus
radiodurans) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30)
PF14490
(HHH_4) 		5 LEU A 311
LEU A 449
ILE A 433
ALA A 456
LEU A 431
 None
 1.12A 5ienB-3e1sA:
undetectable		 5ienB-3e1sA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Francisella
tularensis) 		PF02540
(NAD_synthase) 		5 ILE A  90
TYR A  86
GLU A  84
THR A  57
LEU A  61
 None
None
None
None
AMP  A3001 (-4.2A)
 1.19A 5ienB-3fiuA:
undetectable		 5ienB-3fiuA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ged SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Ruminiclostridium
thermocellum) 		PF13561
(adh_short_C2) 		5 LEU A  62
PHE A  65
LEU A 113
ILE A 129
ALA A  83
 None
None
None
None
THJ  A 249 ( 4.1A)
 1.19A 5ienB-3gedA:
undetectable		 5ienB-3gedA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glg DNA POLYMERASE III
SUBUNIT DELTA'

(Escherichia
coli) 		PF09115
(DNApol3-delta_C)
PF13177
(DNA_pol3_delta2) 		5 LEU E 286
TRP E 229
LEU E 316
LEU E 252
LEU E 216
 None
 1.22A 5ienB-3glgE:
undetectable		 5ienB-3glgE:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2

(Trypanosoma
brucei) 		PF01704
(UDPGP) 		5 LEU A 396
LEU A  97
LEU A 222
ALA A 111
LEU A 129
 None
 1.13A 5ienB-3gueA:
undetectable		 5ienB-3gueA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op1 MACROLIDE-EFFLUX
PROTEIN

(Streptococcus
pneumoniae) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		5 PHE A 102
LEU A  23
LEU A  96
THR A 113
ALA A 117
 None
GOL  A 318 ( 4.5A)
None
None
None
 1.22A 5ienB-3op1A:
undetectable		 5ienB-3op1A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvo C-REACTIVE PROTEIN

(Homo sapiens) 		PF00354
(Pentaxin) 		5 LEU A 190
MET A   4
ILE A 156
TYR A  54
LEU A 135
 None
 1.22A 5ienB-3pvoA:
undetectable		 5ienB-3pvoA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q13 SPONDIN-1

(Homo sapiens) 		PF06468
(Spond_N) 		5 LEU A 262
ILE A 235
THR A 357
ALA A 355
LEU A 317
 None
 1.23A 5ienB-3q13A:
undetectable		 5ienB-3q13A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		5 LEU A 298
LEU A 277
ILE A 191
ALA A  56
LEU A  53
 None
 1.23A 5ienB-3q1oA:
undetectable		 5ienB-3q1oA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvl PUTATIVE HYDANTOIN
RACEMASE

(Klebsiella
pneumoniae) 		PF01177
(Asp_Glu_race) 		5 LEU A 237
PHE A 241
LEU A 244
ILE A   9
ALA A  87
 None
 1.18A 5ienB-3qvlA:
undetectable		 5ienB-3qvlA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6p CAPSID PROTEIN

(Helicoverpa
armigera stunt
virus) 		PF03566
(Peptidase_A21) 		5 LEU A 493
ILE A 218
TYR A 408
THR A 290
ALA A 407
 None
 1.23A 5ienB-3s6pA:
undetectable		 5ienB-3s6pA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tat TYROSINE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 LEU A 284
LEU A  95
ILE A 240
GLU A  74
LEU A  87
 None
 1.21A 5ienB-3tatA:
undetectable		 5ienB-3tatA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 LEU A  98
MET A  96
LEU A 153
ILE A 182
LEU A 177
 None
 1.22A 5ienB-3u1kA:
undetectable		 5ienB-3u1kA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b45 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		5 LEU A   5
PHE A  98
LEU A 225
LEU A  19
ALA A 195
 None
 1.19A 5ienB-4b45A:
undetectable		 5ienB-4b45A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF01839
(FG-GAP)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF08441
(Integrin_alpha2)
PF17205
(PSI_integrin) 		5 LEU B 262
LEU A 322
ILE B 325
TYR A 288
THR A 263
 None
 1.23A 5ienB-4cakB:
undetectable		 5ienB-4cakB:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cj0 ENDOGLUCANASE D

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		5 LEU A 245
PHE A 244
LEU A 248
ILE A 211
LEU A 406
 None
 1.11A 5ienB-4cj0A:
undetectable		 5ienB-4cj0A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpo CONSERVED PROTEIN

(Methanosarcina
mazei) 		PF03992
(ABM) 		5 PHE A  73
LEU A  64
LEU A  27
THR A  88
ALA A   8
 None
 1.15A 5ienB-4dpoA:
1.8		 5ienB-4dpoA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewg BETA-KETOACYL
SYNTHASE

(Paraburkholderia
phymatum) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		6 LEU A 402
ILE A   6
TYR A 105
THR A 160
ALA A 104
LEU A 240
 None
 1.19A 5ienB-4ewgA:
undetectable		 5ienB-4ewgA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 LEU A 569
ILE A 562
GLU A 508
ALA A 549
LEU A 597
 None
 1.04A 5ienB-4fddA:
undetectable		 5ienB-4fddA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 204
ILE A 263
GLU A 459
THR A 319
LEU A 227
 None
None
None
HEM  A 601 (-4.6A)
None
 1.05A 5ienB-4fdhA:
undetectable		 5ienB-4fdhA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 LEU A 398
LEU A 484
LEU A 504
THR A 512
LEU A 521
 None
 1.22A 5ienB-4fysA:
2.0		 5ienB-4fysA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gou EHRGS-RHOGEF

(Entamoeba
histolytica) 		PF00615
(RGS)
PF00621
(RhoGEF) 		5 TRP A  13
LEU A 132
ILE A 365
TYR A 271
LEU A 369
 None
 1.12A 5ienB-4gouA:
undetectable		 5ienB-4gouA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		5 TRP C 366
LEU C 369
ILE C 419
ALA C 343
LEU C 340
 None
 1.20A 5ienB-4hb4C:
undetectable		 5ienB-4hb4C:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jj9 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE

(Bordetella
bronchiseptica) 		PF02962
(CHMI) 		5 LEU A 110
LEU A 107
ILE A  99
ALA A  50
LEU A   4
 None
 1.23A 5ienB-4jj9A:
undetectable		 5ienB-4jj9A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ltm NADH-DEPENDENT FMN
REDUCTASE

(EDTA-degrading
bacterium BNC1) 		PF03358
(FMN_red) 		5 LEU A  55
LEU A  60
ILE A  43
ALA A  90
LEU A  87
 None
 1.19A 5ienB-4ltmA:
undetectable		 5ienB-4ltmA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maa PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		5 LEU A 225
MET A 250
LEU A 183
ILE A 198
TYR A 202
 None
 1.23A 5ienB-4maaA:
undetectable		 5ienB-4maaA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgq GLYCOSYL HYDROLASE
FAMILY 10

(Prevotella
bryantii) 		PF02018
(CBM_4_9) 		5 LEU A 255
TRP A 276
LEU A 154
LEU A 186
LEU A 241
 None
 1.00A 5ienB-4mgqA:
undetectable		 5ienB-4mgqA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nav HYPOTHETICAL PROTEIN
XCC279

(Xanthomonas
campestris) 		no annotation 5 LEU D 126
ILE D  64
THR D  30
ALA D 159
LEU D  59
 None
 1.22A 5ienB-4navD:
undetectable		 5ienB-4navD:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzr PROTEIN M TD

(Mycoplasma
genitalium) 		no annotation 5 LEU M 169
LEU M 292
ILE M 305
THR M 243
LEU M 281
 None
 1.18A 5ienB-4nzrM:
undetectable		 5ienB-4nzrM:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		6 PHE A 336
LEU A 358
ILE A 422
TYR A  82
GLU A  78
ALA A 416
 None
None
None
ACT  A 703 (-4.8A)
None
None
 1.24A 5ienB-4qjyA:
undetectable		 5ienB-4qjyA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A1050
LEU A 944
LEU A1047
ILE A 913
TYR A 988
 None
 1.09A 5ienB-4qpmA:
undetectable		 5ienB-4qpmA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsx TYPE III EFFECTOR
HOPA1

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 LEU A 174
LEU A 248
LEU A 177
ILE A 256
TYR A 219
 None
 1.23A 5ienB-4rsxA:
undetectable		 5ienB-4rsxA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvm CITRATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00285
(Citrate_synt) 		5 LEU A 120
LEU A 392
LEU A 116
ILE A 110
TYR A 148
 None
 1.18A 5ienB-4tvmA:
undetectable		 5ienB-4tvmA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u GLOBIN C CHAIN

(Glossoscolex
paulistus) 		PF00042
(Globin) 		5 PHE C 111
LEU C  38
LEU C 142
ALA C  75
LEU C  73
 HEM  C 201 (-3.7A)
CYN  C 202 (-4.7A)
HEM  C 201 (-4.8A)
HEM  C 201 (-3.6A)
None
 1.06A 5ienB-4u8uC:
3.5		 5ienB-4u8uC:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yei BETA1MUT

(synthetic
construct) 		PF00805
(Pentapeptide) 		5 LEU A  42
MET A  21
LEU A  87
ALA A  75
LEU A  52
 None
 1.18A 5ienB-4yeiA:
undetectable		 5ienB-4yeiA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zev PFHAD1

(Plasmodium
falciparum) 		PF08282
(Hydrolase_3) 		5 LEU A 208
ILE A 124
TYR A 148
GLU A 152
LEU A 176
 None
None
M6P  A 302 ( 4.9A)
M6P  A 302 (-2.2A)
None
 1.20A 5ienB-4zevA:
undetectable		 5ienB-4zevA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 LEU A 113
PHE A 112
LEU A 847
TYR A 838
LEU A 878
 None
 1.18A 5ienB-5a22A:
undetectable		 5ienB-5a22A:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2a APO FORM OF
ANOXYBACILLUS
ALPHA-AMYLASES

(Anoxybacillus
ayderensis) 		PF00128
(Alpha-amylase) 		5 LEU A 445
LEU A 306
ILE A 274
ALA A 339
LEU A 285
 None
 1.21A 5ienB-5a2aA:
2.9		 5ienB-5a2aA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		5 MET A1177
TYR A1294
GLU A1276
ALA A1297
LEU A1603
 None
 1.03A 5ienB-5a31A:
2.5		 5ienB-5a31A:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqk ICP27

(Human
alphaherpesvirus
1) 		PF05459
(Herpes_UL69) 		5 LEU A 407
LEU A 390
LEU A 402
ILE A 495
LEU A 476
 None
 1.12A 5ienB-5bqkA:
undetectable		 5ienB-5bqkA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bth DECAPPING NUCLEASE
RAI1

(Candida
albicans) 		PF08652
(RAI1) 		5 LEU A   7
TRP A 334
LEU A 335
ILE A 105
LEU A 122
 None
 1.24A 5ienB-5bthA:
undetectable		 5ienB-5bthA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz4 BETA-KETOTHIOLASE

(Mycolicibacterium
smegmatis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A  77
LEU A  55
ILE A 266
ALA A  35
LEU A  39
 None
 1.19A 5ienB-5bz4A:
undetectable		 5ienB-5bz4A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8

(Homo sapiens) 		PF00005
(ABC_tran)
PF01061
(ABC2_membrane) 		5 LEU A 575
PHE A 502
LEU A 423
ILE B 578
THR A 430
 None
 1.13A 5ienB-5do7A:
undetectable		 5ienB-5do7A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		5 LEU A 371
LEU A  65
MET A  68
ILE A  46
ALA A  18
 None
None
None
FAD  A 401 (-4.6A)
None
 1.16A 5ienB-5eowA:
undetectable		 5ienB-5eowA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evl BETA-LACTAMASE

(Chromobacterium
violaceum) 		PF00144
(Beta-lactamase) 		5 LEU A 183
LEU A 269
LEU A 179
ALA A  80
LEU A  84
 None
 1.08A 5ienB-5evlA:
undetectable		 5ienB-5evlA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foi MYCINAMICIN VIII C21
METHYL HYDROXYLASE

(Micromonospora
griseorubida) 		PF00067
(p450) 		5 LEU A 223
LEU A  80
THR A 231
ALA A 274
LEU A 302
 MY8  A 414 (-4.0A)
HEM  A 413 ( 3.7A)
HEM  A 413 (-3.6A)
HEM  A 413 (-3.6A)
None
 1.13A 5ienB-5foiA:
undetectable		 5ienB-5foiA:
16.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ieo CDL2.3A

(synthetic
construct) 		PF14534
(DUF4440) 		7 LEU A  12
PHE A  15
ILE A 100
TYR A 104
GLU A 106
THR A 121
ALA A 123
 VDY  A 206 ( 4.3A)
VDY  A 206 (-3.5A)
VDY  A 206 (-2.9A)
VDY  A 206 ( 2.8A)
VDY  A 206 (-2.4A)
VDY  A 206 (-3.4A)
VDY  A 206 ( 3.1A)
 0.71A 5ienB-5ieoA:
22.7		 5ienB-5ieoA:
91.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ieo CDL2.3A

(synthetic
construct) 		PF14534
(DUF4440) 		7 LEU A  12
PHE A  15
LEU A  54
ILE A 100
TYR A 104
GLU A 106
ALA A 123
 VDY  A 206 ( 4.3A)
VDY  A 206 (-3.5A)
VDY  A 206 ( 3.9A)
VDY  A 206 (-2.9A)
VDY  A 206 ( 2.8A)
VDY  A 206 (-2.4A)
VDY  A 206 ( 3.1A)
 1.34A 5ienB-5ieoA:
22.7		 5ienB-5ieoA:
91.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ieo CDL2.3A

(synthetic
construct) 		PF14534
(DUF4440) 		9 LEU A  12
PHE A  15
TRP A  55
LEU A  58
MET A  61
TYR A 104
GLU A 106
THR A 121
ALA A 123
 VDY  A 206 ( 4.3A)
VDY  A 206 (-3.5A)
VDY  A 206 ( 4.4A)
VDY  A 206 ( 4.7A)
VDY  A 206 ( 3.1A)
VDY  A 206 ( 2.8A)
VDY  A 206 (-2.4A)
VDY  A 206 (-3.4A)
VDY  A 206 ( 3.1A)
 0.42A 5ienB-5ieoA:
22.7		 5ienB-5ieoA:
91.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqk PEPTIDASE, PUTATIVE

(Plasmodium
falciparum) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 LEU A 366
PHE A 367
LEU A 347
ILE A 452
LEU A 343
 None
 1.20A 5ienB-5jqkA:
1.2		 5ienB-5jqkA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kem BDBV91 VARIABLE FAB
DOMAIN HEAVY CHAIN

(Homo sapiens) 		PF07686
(V-set) 		5 LEU B  82
LEU B  82
ILE B  51
TYR B  90
THR B 107
 None
 1.06A 5ienB-5kemB:
undetectable		 5ienB-5kemB:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans) 		no annotation 5 PHE B 541
TRP B 661
LEU B 669
GLU B 503
ALA B 505
 None
 1.08A 5ienB-5khnB:
undetectable		 5ienB-5khnB:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6

(Bos taurus) 		PF00146
(NADHdh)
PF00420
(Oxidored_q2)
PF00499
(Oxidored_q3) 		5 LEU H 100
PHE H 160
LEU H 103
ILE J  59
LEU K  64
 None
 1.13A 5ienB-5lc5H:
undetectable		 5ienB-5lc5H:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		5 MET A1177
TYR A1294
GLU A1276
ALA A1297
LEU A1603
 None
 1.00A 5ienB-5lcwA:
undetectable		 5ienB-5lcwA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER

(Prochlorococcus
marinus) 		no annotation 5 LEU A 117
LEU A 175
LEU A 114
ILE A 199
LEU A 196
 None
 1.15A 5ienB-5lq8A:
undetectable		 5ienB-5lq8A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC

(Flaveria
trinervia) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		5 LEU A 269
LEU A 292
ILE A 275
TYR A 303
ALA A 302
 None
 1.06A 5ienB-5lu4A:
undetectable		 5ienB-5lu4A:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-) 		no annotation 5 LEU A 275
LEU A 384
ILE A 502
GLU A 224
THR A 158
 None
 1.05A 5ienB-5mz9A:
4.5		 5ienB-5mz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvh OCTOPINE
CATABOLISM/UPTAKE
OPERON REGULATORY
PROTEIN OCCR

(Agrobacterium
tumefaciens) 		PF03466
(LysR_substrate) 		5 LEU A 162
MET A 297
LEU A 225
ALA A 100
LEU A 105
 None
 1.17A 5ienB-5vvhA:
undetectable		 5ienB-5vvhA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2

(Leptotrichia
shahii) 		no annotation 5 PHE A1340
LEU A1331
LEU A1342
ILE A1375
THR A1317
 None
 1.18A 5ienB-5wtkA:
undetectable		 5ienB-5wtkA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 5 MET A 778
LEU A 559
ILE A 815
ALA A 824
LEU A 819
 None
 1.15A 5ienB-5wugA:
1.8		 5ienB-5wugA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A

(Oryzias latipes) 		PF01094
(ANF_receptor) 		5 LEU A 406
LEU A  39
ILE A 151
ALA A 133
LEU A 114
 None
 1.18A 5ienB-5x2qA:
undetectable		 5ienB-5x2qA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbk IMPORTIN-4

(Homo sapiens) 		no annotation 5 LEU D1008
PHE D1005
LEU D 991
ILE D 961
LEU D 949
 None
 1.21A 5ienB-5xbkD:
undetectable		 5ienB-5xbkD:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xev XAA-PRO
DIPEPTIDASE,PEPTIDAS
E-RELATED PROTEIN

(Deinococcus
radiodurans) 		no annotation 5 LEU A 393
LEU A 382
GLU A 278
ALA A 280
LEU A 336
 None
 1.09A 5ienB-5xevA:
undetectable		 5ienB-5xevA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aun PLA2G6, IPLA2BETA

(Cricetulus
griseus) 		no annotation 5 LEU A 470
LEU A 457
LEU A 429
ILE A 635
LEU A 745
 None
 1.19A 5ienB-6aunA:
undetectable		 5ienB-6aunA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fv5 QUEUINE
TRNA-RIBOSYLTRANSFER
ASE ACCESSORY
SUBUNIT 2

(Mus musculus) 		no annotation 5 LEU A  64
PHE A 129
LEU A 171
LEU A  96
ILE A 193
 None
 1.17A 5ienB-6fv5A:
undetectable		 5ienB-6fv5A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gqd GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Homo sapiens) 		no annotation 6 PHE A 131
TRP A 154
LEU A 139
ILE A 278
TYR A 296
LEU A 255
 None
 1.28A 5ienB-6gqdA:
undetectable		 5ienB-6gqdA:
undetectable