SIMILAR PATTERNS OF AMINO ACIDS FOR 5IEN_B_VDYB201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ir6 EXONUCLEASE RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 PRO A 185
LEU A  55
ILE A  91
LEU A  92
LEU A  50
 None
 1.13A 5ienB-1ir6A:
0.0		 5ienB-1ir6A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mv5 MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Lactococcus
lactis) 		PF00005
(ABC_tran) 		5 ILE A 372
MET A 503
VAL A 348
ILE A 551
PRO A 395
 None
 0.95A 5ienB-1mv5A:
0.0		 5ienB-1mv5A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkq HYPOTHETICAL 28.8
KDA PROTEIN IN
PSD1-SKO1 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF01557
(FAA_hydrolase) 		5 ILE A 211
LEU A 213
VAL A 172
LEU A 233
LEU A   6
 None
 1.17A 5ienB-1nkqA:
0.0		 5ienB-1nkqA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obb ALPHA-GLUCOSIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 ILE A 345
VAL A  35
ILE A  48
LEU A  37
LEU A 322
 None
 0.77A 5ienB-1obbA:
0.0		 5ienB-1obbA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF

(Bacillus
subtilis) 		PF01926
(MMR_HSR1) 		5 ILE A  85
LEU A  93
VAL A 163
ILE A 125
LEU A 169
 None
 1.15A 5ienB-1pujA:
undetectable		 5ienB-1pujA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		5 ILE A  99
VAL A  62
ILE A   7
LEU A  21
PRO A  18
 None
 1.14A 5ienB-1q5aA:
undetectable		 5ienB-1q5aA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio sp.
PA-44) 		PF00082
(Peptidase_S8) 		5 TYR A  22
VAL A  31
ILE A  78
PRO A 122
LEU A   8
 None
 1.00A 5ienB-1s2nA:
undetectable		 5ienB-1s2nA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgw PUTATIVE ABC
TRANSPORTER

(Pyrococcus
furiosus) 		PF00005
(ABC_tran) 		5 ILE A  85
LEU A 123
VAL A 116
ILE A 107
LEU A 111
 None
 1.19A 5ienB-1sgwA:
0.0		 5ienB-1sgwA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Synechococcus
elongatus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 ILE A 354
PRO A 408
ILE A 422
LEU A 426
PRO A 451
 None
 1.14A 5ienB-1tezA:
undetectable		 5ienB-1tezA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u60 PROBABLE GLUTAMINASE
YBAS

(Escherichia
coli) 		PF04960
(Glutaminase) 		5 ILE A 142
LEU A 226
VAL A 269
LEU A 267
PRO A 257
 None
 1.18A 5ienB-1u60A:
undetectable		 5ienB-1u60A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzx COG3291: FOG: PKD
REPEAT

(Ruminiclostridium
thermocellum) 		no annotation 5 ILE A 138
LEU A 143
VAL A 155
ILE A  13
LEU A  70
 None
 1.09A 5ienB-1wzxA:
undetectable		 5ienB-1wzxA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4f MATRIN 3

(Mus musculus) 		PF00076
(RRM_1) 		5 PRO A  49
VAL A  94
ILE A  28
LEU A  30
PRO A  34
 None
 1.00A 5ienB-1x4fA:
undetectable		 5ienB-1x4fA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 VAL A 518
ILE A 545
LEU A 547
PRO A 551
LEU A 159
 None
 1.06A 5ienB-1xkwA:
1.2		 5ienB-1xkwA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9i LOW TEMPERATURE
REQUIREMENT C
PROTEIN

(Listeria
monocytogenes) 		PF04608
(PgpA) 		5 LEU A  56
VAL A 147
ILE A  69
LEU A 143
LEU A  10
 None
 1.15A 5ienB-1y9iA:
undetectable		 5ienB-1y9iA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztd HYPOTHETICAL PROTEIN
PFU-631545-001

(Pyrococcus
furiosus) 		PF11469
(Ribonucleas_3_2) 		5 ILE A  86
PRO A 111
VAL A  35
ILE A  69
PRO A  36
 None
 1.09A 5ienB-1ztdA:
undetectable		 5ienB-1ztdA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC

(Homo sapiens) 		PF01063
(Aminotran_4) 		5 LEU A 261
VAL A 323
ILE A 348
LEU A 318
LEU A 246
 None
 1.18A 5ienB-2abjA:
undetectable		 5ienB-2abjA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5y REGULATOR OF
G-PROTEIN SIGNALLING
3 ISOFORM 1

(Homo sapiens) 		PF00595
(PDZ) 		5 ILE A  21
LEU A  54
VAL A  38
LEU A  76
PRO A  37
 None
 1.09A 5ienB-2f5yA:
undetectable		 5ienB-2f5yA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzq PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN

(Plasmodium
vivax) 		PF01161
(PBP) 		5 MET A  31
LEU A  27
VAL A  19
ILE A 174
PRO A  78
 None
 1.18A 5ienB-2gzqA:
undetectable		 5ienB-2gzqA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 ILE A 326
LEU A 329
ILE A 764
LEU A 768
LEU A 338
 None
 1.12A 5ienB-2iujA:
undetectable		 5ienB-2iujA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy8 PROTEIN PM0188

(Pasteurella
multocida) 		PF11477
(PM0188) 		5 ILE A 184
VAL A 195
ILE A 110
LEU A 138
LEU A 211
 None
 1.19A 5ienB-2iy8A:
undetectable		 5ienB-2iy8A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obn HYPOTHETICAL PROTEIN

(Trichormus
variabilis) 		PF07755
(DUF1611)
PF17396
(DUF1611_N) 		5 ILE A 129
LEU A  99
VAL A  65
ILE A  78
LEU A  12
 None
 1.13A 5ienB-2obnA:
undetectable		 5ienB-2obnA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		5 ILE A 318
LEU A 260
ILE A 249
LEU A 300
PRO A 368
 None
None
None
None
GOL  A3017 (-4.2A)
 1.09A 5ienB-2okxA:
undetectable		 5ienB-2okxA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p67 LAO/AO TRANSPORT
SYSTEM KINASE

(Escherichia
coli) 		PF03308
(ArgK) 		5 ILE A 246
LEU A  77
VAL A 149
ILE A 172
LEU A  57
 None
 0.82A 5ienB-2p67A:
undetectable		 5ienB-2p67A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qn0 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		5 TYR A  76
PRO A 168
ILE A  90
LEU A  93
LEU A  77
 None
 1.19A 5ienB-2qn0A:
undetectable		 5ienB-2qn0A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00583
(Acetyltransf_1)
PF00696
(AA_kinase) 		6 ILE A 167
LEU A 125
VAL A 102
ILE A  30
LEU A  35
LEU A  50
 None
 1.49A 5ienB-2r98A:
undetectable		 5ienB-2r98A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum) 		PF00026
(Asp) 		5 ILE A 297
VAL A 184
LEU A 317
PRO A 315
LEU A 221
 PP6  A 327 (-4.2A)
None
None
None
None
 1.19A 5ienB-2wedA:
undetectable		 5ienB-2wedA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3i PENICILLIN-BINDING
PROTEIN 4

(Haemophilus
influenzae) 		PF02113
(Peptidase_S13) 		5 MET A 306
LEU A 389
VAL A 376
ILE A 343
LEU A 344
 None
 1.16A 5ienB-3a3iA:
undetectable		 5ienB-3a3iA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE

(Mesorhizobium
japonicum) 		PF01494
(FAD_binding_3) 		5 LEU A 242
VAL A 184
ILE A 212
LEU A 224
PRO A 185
 None
 1.07A 5ienB-3allA:
undetectable		 5ienB-3allA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djn PROTEIN BTG2

(Mus musculus) 		PF07742
(BTG) 		5 ILE B  78
LEU B  92
VAL B  30
LEU B  35
LEU B 102
 None
 0.98A 5ienB-3djnB:
undetectable		 5ienB-3djnB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvh MALATE DEHYDROGENASE

(Brucella
abortus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A 288
LEU A 290
VAL A 266
ILE A 285
LEU A 260
 None
 1.08A 5ienB-3gvhA:
undetectable		 5ienB-3gvhA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hb0 EYES ABSENT HOMOLOG
2 (DROSOPHILA)

(Homo sapiens) 		PF00702
(Hydrolase) 		5 ILE A 520
VAL A 466
ILE A 280
LEU A 463
PRO A 468
 None
 1.17A 5ienB-3hb0A:
undetectable		 5ienB-3hb0A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE

(Medicago
truncatula) 		PF00201
(UDPGT) 		5 ILE A 231
PRO A 180
LEU A 153
VAL A 194
LEU A 190
 None
 1.00A 5ienB-3hbjA:
undetectable		 5ienB-3hbjA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		5 TYR A 233
ILE A 221
VAL A  50
ILE A 211
LEU A  38
 None
 1.18A 5ienB-3hjeA:
undetectable		 5ienB-3hjeA:
11.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hx8 PUTATIVE KETOSTEROID
ISOMERASE

(Mesorhizobium
loti) 		PF14534
(DUF4440) 		5 TYR A  52
LEU A  75
LEU A 109
PRO A 112
LEU A 139
 None
None
UNL  A 200 (-4.9A)
None
None
 0.54A 5ienB-3hx8A:
22.6		 5ienB-3hx8A:
89.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hx8 PUTATIVE KETOSTEROID
ISOMERASE

(Mesorhizobium
loti) 		PF14534
(DUF4440) 		5 TYR A  52
PRO A  60
LEU A 109
PRO A 112
LEU A 139
 None
None
UNL  A 200 (-4.9A)
None
None
 0.88A 5ienB-3hx8A:
22.6		 5ienB-3hx8A:
89.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ian CHITINASE

(Lactococcus
lactis) 		PF00704
(Glyco_hydro_18) 		5 ILE A 145
LEU A 179
ILE A 131
LEU A 161
PRO A 199
 None
 1.12A 5ienB-3ianA:
undetectable		 5ienB-3ianA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S27,
MITOCHONDRIAL

(Bos taurus) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		5 ILE e 137
PRO e 139
LEU e 129
LEU e 117
LEU e  92
 None
 1.00A 5ienB-3jd5e:
undetectable		 5ienB-3jd5e:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxo TRKA-N DOMAIN
PROTEIN

(Thermotoga sp.
RQ2) 		PF02080
(TrkA_C) 		5 ILE A 178
PRO A 187
LEU A 199
PRO A 170
LEU A 194
 None
 1.16A 5ienB-3jxoA:
undetectable		 5ienB-3jxoA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN

(Rhodobacter
sphaeroides) 		PF02126
(PTE) 		5 ILE A 262
ILE A 297
LEU A 288
PRO A 244
LEU A 325
 None
 1.16A 5ienB-3k2gA:
undetectable		 5ienB-3k2gA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcq PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Anaplasma
phagocytophilum) 		PF00551
(Formyl_trans_N) 		5 ILE A  11
VAL A  79
ILE A  70
LEU A  74
LEU A  47
 None
 1.18A 5ienB-3kcqA:
undetectable		 5ienB-3kcqA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lye OXALOACETATE ACETYL
HYDROLASE

(Cryphonectria
parasitica) 		PF13714
(PEP_mutase) 		5 PRO A 151
VAL A 255
ILE A 306
LEU A 280
PRO A 278
 None
 1.16A 5ienB-3lyeA:
undetectable		 5ienB-3lyeA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 LEU B1345
VAL B1430
ILE B1425
LEU B1427
LEU B1365
 None
 1.19A 5ienB-3prxB:
undetectable		 5ienB-3prxB:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzy MOG

(Mycobacterium
avium) 		PF00994
(MoCF_biosynth) 		6 ILE A  28
VAL A  51
ILE A  66
LEU A  55
PRO A  50
LEU A 142
 None
 1.39A 5ienB-3pzyA:
undetectable		 5ienB-3pzyA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q0x CENTRIOLE PROTEIN

(Chlamydomonas
reinhardtii) 		PF16531
(SAS-6_N) 		5 LEU A 128
VAL A  29
ILE A 106
LEU A 110
PRO A  28
 None
 1.09A 5ienB-3q0xA:
2.7		 5ienB-3q0xA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qeh FAB FRAGMENT OF
HUMAN ANTI-HIV-1 ENV
ANTIBODY N12-I15,
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 TYR A 176
LEU A 108
VAL A  18
LEU A  82
LEU A 170
 None
 1.17A 5ienB-3qehA:
undetectable		 5ienB-3qehA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 PRO A 433
VAL A 468
ILE A 542
LEU A 421
LEU A 607
 None
 1.13A 5ienB-3s95A:
undetectable		 5ienB-3s95A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tej ENTEROBACTIN
SYNTHASE COMPONENT F

(Escherichia
coli) 		PF00550
(PP-binding)
PF00975
(Thioesterase) 		5 ILE A1094
LEU A1068
ILE A1275
LEU A1164
LEU A1058
 None
 1.15A 5ienB-3tejA:
undetectable		 5ienB-3tejA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to3 PETROBACTIN
BIOSYNTHESIS PROTEIN
ASBB

(Bacillus
anthracis) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 PRO A 162
LEU A  32
VAL A 110
ILE A 119
LEU A 115
 None
 1.19A 5ienB-3to3A:
2.5		 5ienB-3to3A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uss PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF05995
(CDO_I) 		5 ILE A 192
PRO A 190
LEU A   7
ILE A 156
LEU A 100
 None
NA  A 218 ( 4.2A)
None
None
None
 1.18A 5ienB-3ussA:
undetectable		 5ienB-3ussA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu1 PUTATIVE
UNCHARACTERIZED
PROTEIN PH0242

(Pyrococcus
horikoshii) 		no annotation 5 PRO A 953
LEU A 830
VAL A 861
ILE A 909
LEU A 911
 None
 1.07A 5ienB-3vu1A:
undetectable		 5ienB-3vu1A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		6 TYR A 283
ILE A 281
VAL A 303
ILE A 294
PRO A 300
LEU A 196
 None
 1.46A 5ienB-3welA:
1.3		 5ienB-3welA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1

(Yersinia pestis) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		5 ILE A 254
LEU A 258
VAL A 132
ILE A  47
LEU A  45
 None
 1.00A 5ienB-3zu4A:
undetectable		 5ienB-3zu4A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae) 		PF01926
(MMR_HSR1)
PF02824
(TGS)
PF16897
(MMR_HSR1_Xtn) 		5 ILE A 272
LEU A  81
VAL A  68
LEU A 145
LEU A 249
 None
 1.07A 5ienB-4a9aA:
undetectable		 5ienB-4a9aA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axn CHITINASE C1

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		5 ILE A 124
LEU A 158
ILE A 110
LEU A 140
PRO A 178
 None
 1.13A 5ienB-4axnA:
undetectable		 5ienB-4axnA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX ALPHA-CHAIN
FADB
FATTY ACID
BETA-OXIDATION
COMPLEX BETA-CHAIN
FADA

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
PF02803
(Thiolase_C) 		5 TYR A 286
ILE A 282
VAL C 194
LEU C  31
PRO C  14
 None
 1.02A 5ienB-4b3iA:
undetectable		 5ienB-4b3iA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzt AQUALYSIN-1

(Thermus
aquaticus) 		PF00082
(Peptidase_S8) 		5 TYR A  24
VAL A  33
ILE A  78
PRO A 122
LEU A  10
 None
 1.01A 5ienB-4dztA:
undetectable		 5ienB-4dztA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4u MANDALATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(unidentified) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A   3
PRO A  67
LEU A 366
PRO A 364
LEU A   6
 None
 1.17A 5ienB-4e4uA:
undetectable		 5ienB-4e4uA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gip FUSION GLYCOPROTEIN
F1

(Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly) 		5 ILE D 206
LEU D 203
ILE D 259
LEU D 262
LEU D 224
 None
 1.17A 5ienB-4gipD:
undetectable		 5ienB-4gipD:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gw9 BACTERIOPHYTOCHROME

(Rhodopseudomonas
palustris) 		PF00360
(PHY)
PF00989
(PAS)
PF01590
(GAF)
PF08446
(PAS_2) 		5 ILE A  47
LEU A  64
ILE A 118
LEU A 240
LEU A  58
 None
 1.16A 5ienB-4gw9A:
undetectable		 5ienB-4gw9A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A

(Burkholderia
glumae) 		PF05853
(BKACE) 		5 ILE A 446
LEU A 456
ILE A 405
LEU A 409
LEU A 463
 None
 1.20A 5ienB-4nnbA:
undetectable		 5ienB-4nnbA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qaf LIPOCALIN-1

(Homo sapiens) 		PF00061
(Lipocalin) 		5 ILE A  80
LEU A  19
VAL A  53
LEU A 115
PRO A  38
 None
 1.16A 5ienB-4qafA:
undetectable		 5ienB-4qafA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi7 CELLOBIOSE
DEHYDROGENASE

(Neurospora
crassa) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		5 PRO A 579
LEU A 382
VAL A 668
ILE A 537
LEU A 671
 None
None
NAG  A 908 ( 4.8A)
None
None
 1.13A 5ienB-4qi7A:
undetectable		 5ienB-4qi7A:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ttw CENTRIOLE PROTEIN

(Chlamydomonas
reinhardtii) 		PF16531
(SAS-6_N) 		5 LEU A 128
VAL A  29
ILE A 106
LEU A 110
PRO A  28
 None
 1.19A 5ienB-4ttwA:
undetectable		 5ienB-4ttwA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twg MOLYBDOPTERIN
BIOSYNTHESIS MOG
PROTEIN

(Mycobacterium
ulcerans) 		PF00994
(MoCF_biosynth) 		6 ILE A  29
VAL A  52
ILE A  67
LEU A  56
PRO A  51
LEU A 143
 None
 1.40A 5ienB-4twgA:
undetectable		 5ienB-4twgA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5z CHITINASE 60

(Moritella
marina) 		PF00704
(Glyco_hydro_18) 		5 ILE A 136
LEU A 170
ILE A 122
LEU A 152
PRO A 190
 None
 1.12A 5ienB-4w5zA:
undetectable		 5ienB-4w5zA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj7 MALCAVERNIN

(Homo sapiens) 		no annotation 5 ILE A  76
LEU A  80
VAL A 145
ILE A 197
LEU A 152
 None
 1.16A 5ienB-4wj7A:
undetectable		 5ienB-4wj7A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wnr LEUCINE-RICH-REPEAT
PROTEIN

(Methanosarcina
barkeri) 		PF08477
(Roc)
PF16095
(COR) 		5 ILE A 458
LEU A 337
VAL A 324
LEU A 396
LEU A 429
 None
 1.05A 5ienB-4wnrA:
undetectable		 5ienB-4wnrA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wnz CRISPR SYSTEM CMR
SUBUNIT CMR4

(Pyrococcus
furiosus) 		PF03787
(RAMPs) 		5 ILE A  82
LEU A 258
VAL A 281
LEU A   8
LEU A 241
 None
 1.12A 5ienB-4wnzA:
undetectable		 5ienB-4wnzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3

(Mus musculus) 		PF13855
(LRR_8) 		5 ILE B 177
PRO B 174
LEU B 159
VAL B 140
LEU B 204
 None
 1.11A 5ienB-4yebB:
undetectable		 5ienB-4yebB:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ym3 GALECTIN-4

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 MET A 241
VAL A 192
ILE A 210
LEU A 318
LEU A 235
 None
 1.04A 5ienB-4ym3A:
1.6		 5ienB-4ym3A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4x REELIN

(Mus musculus) 		PF07974
(EGF_2) 		5 ILE A2656
LEU A2563
VAL A2566
ILE A2661
LEU A2568
 None
 1.17A 5ienB-5b4xA:
undetectable		 5ienB-5b4xA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz3 NA(+)/H(+)
ANTIPORTER

(Thermus
thermophilus) 		PF00999
(Na_H_Exchanger) 		5 ILE A 261
PRO A 260
LEU A 220
VAL A 212
LEU A 207
 None
 1.17A 5ienB-5bz3A:
undetectable		 5ienB-5bz3A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0u ALKYLMERCURY LYASE

(Escherichia
coli) 		PF03243
(MerB)
PF12324
(HTH_15) 		5 ILE A  45
LEU A  46
VAL A  56
ILE A  71
LEU A  57
 None
 1.15A 5ienB-5c0uA:
undetectable		 5ienB-5c0uA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chn ANTIBODY 5M16 FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 5 TYR H 185
LEU H 117
VAL H  18
LEU H  86
LEU H 179
 None
 1.18A 5ienB-5chnH:
undetectable		 5ienB-5chnH:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN ALPHA-L

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 VAL A  58
ILE A  83
LEU A 111
PRO A  57
LEU A 359
 None
 1.12A 5ienB-5e6sA:
undetectable		 5ienB-5e6sA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF03170
(BcsB) 		5 ILE B 197
PRO B 233
VAL B 268
ILE B 258
LEU B 282
 None
 1.13A 5ienB-5ej1B:
undetectable		 5ienB-5ej1B:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5end 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG

(Vibrio cholerae) 		PF13561
(adh_short_C2) 		5 ILE A 118
MET A 169
VAL A  84
ILE A  70
LEU A  74
 None
 1.11A 5ienB-5endA:
undetectable		 5ienB-5endA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqv BIFUNCTIONAL
2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
PERIPLASMIC
PRECURSOR PROTEIN

(Yersinia pestis) 		PF00149
(Metallophos) 		5 TYR A 117
ILE A  67
LEU A  35
VAL A 294
PRO A 271
 None
 1.16A 5ienB-5eqvA:
0.4		 5ienB-5eqvA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5f TAU CLASS
GLUTATHIONE
S-TRANSFERASE

(Mangifera
indica) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 ILE A  71
LEU A   8
VAL A 206
ILE A 161
PRO A 208
 None
 1.16A 5ienB-5g5fA:
undetectable		 5ienB-5g5fA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkq ALYGC MUTANT - R241A

(Paraglaciecola
chathamensis) 		PF14592
(Chondroitinas_B) 		5 LEU A 532
VAL A 474
ILE A 486
LEU A 452
LEU A 546
 None
 1.13A 5ienB-5gkqA:
undetectable		 5ienB-5gkqA:
10.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ieo CDL2.3A

(synthetic
construct) 		PF14534
(DUF4440) 		7 ILE A  37
PRO A  39
MET A  42
LEU A  54
VAL A  63
LEU A  88
LEU A 118
 VDY  A 206 ( 3.9A)
VDY  A 206 ( 3.5A)
VDY  A 206 ( 3.5A)
VDY  A 206 ( 3.9A)
None
VDY  A 206 (-4.6A)
VDY  A 206 ( 4.4A)
 0.68A 5ienB-5ieoA:
22.7		 5ienB-5ieoA:
91.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ieo CDL2.3A

(synthetic
construct) 		PF14534
(DUF4440) 		7 TYR A  31
ILE A  37
PRO A  39
MET A  42
LEU A  54
VAL A  63
LEU A 118
 None
VDY  A 206 ( 3.9A)
VDY  A 206 ( 3.5A)
VDY  A 206 ( 3.5A)
VDY  A 206 ( 3.9A)
None
VDY  A 206 ( 4.4A)
 0.25A 5ienB-5ieoA:
22.7		 5ienB-5ieoA:
91.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ieo CDL2.3A

(synthetic
construct) 		PF14534
(DUF4440) 		5 TYR A  31
LEU A  54
VAL A  63
PRO A  91
LEU A 118
 None
VDY  A 206 ( 3.9A)
None
None
VDY  A 206 ( 4.4A)
 0.90A 5ienB-5ieoA:
22.7		 5ienB-5ieoA:
91.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5v IMMUNITY PROTEIN
CDII

(Escherichia
coli) 		no annotation 5 ILE C  53
LEU C  56
VAL C  63
LEU C  64
LEU C  90
 None
 1.18A 5ienB-5j5vC:
undetectable		 5ienB-5j5vC:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1u NAD(P)H:FLAVIN
OXIDOREDUCTASE SYE4

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		5 PRO A 326
LEU A 343
VAL A  10
ILE A  29
LEU A  13
 None
 1.15A 5ienB-5k1uA:
undetectable		 5ienB-5k1uA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2n ELONGATOR COMPLEX
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 ILE A 729
PRO A 751
ILE A 782
LEU A 400
LEU A 731
 None
 1.12A 5ienB-5m2nA:
2.9		 5ienB-5m2nA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD

(Escherichia
coli) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG)
PF13721
(SecD-TM1) 		5 ILE D 435
LEU D 234
VAL D 370
ILE D 272
LEU D 386
 None
 1.18A 5ienB-5mg3D:
undetectable		 5ienB-5mg3D:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN

(Chaetomium
thermophilum) 		no annotation 5 TYR A1557
ILE A1736
PRO A1740
VAL A1810
LEU A1824
 None
 1.17A 5ienB-5nnlA:
undetectable		 5ienB-5nnlA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 ILE A2990
MET A2994
LEU A3062
VAL A3017
LEU A3020
 None
 1.07A 5ienB-5nugA:
undetectable		 5ienB-5nugA:
2.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twa BAK-2 PROTEIN
BCL-X HOMOLOGOUS
PROTEIN, BHP2

(Geodia
cydonium;
Lubomirskia
baicalensis) 		PF00452
(Bcl-2)
no annotation 		5 TYR A 190
MET A  29
ILE A  94
LEU D  75
LEU A 194
 None
None
None
EDO  D 102 ( 4.5A)
None
 1.11A 5ienB-5twaA:
undetectable		 5ienB-5twaA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s CELL DIVISION
CONTROL PROTEIN 45

(Saccharomyces
cerevisiae) 		PF02724
(CDC45) 		5 ILE E 368
LEU E 334
VAL E 344
LEU E 348
LEU E 370
 None
 1.13A 5ienB-5u8sE:
undetectable		 5ienB-5u8sE:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u99 ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF01634
(HisG)
PF08029
(HisG_C) 		5 ILE A 269
VAL A 254
ILE A 274
LEU A 215
PRO A 255
 None
 1.19A 5ienB-5u99A:
undetectable		 5ienB-5u99A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxi CYTOCHROME P450 2C9

(Homo sapiens) 		no annotation 5 PRO A 382
LEU A  29
VAL A  64
ILE A 387
LEU A  77
 None
 1.17A 5ienB-5xxiA:
undetectable		 5ienB-5xxiA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yu1 LYSINE
CYCLODEAMINASE

(Streptomyces
pristinaespiralis) 		no annotation 5 PRO A 217
VAL A 224
ILE A 230
LEU A 228
LEU A 270
 None
 1.18A 5ienB-5yu1A:
1.5		 5ienB-5yu1A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yv5 ATPASE RIL

(Pyrococcus
furiosus) 		no annotation 5 ILE A 474
LEU A 508
VAL A 356
ILE A 395
LEU A 345
 None
 0.99A 5ienB-5yv5A:
undetectable		 5ienB-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 5 TYR 21116
ILE 21191
PRO 21192
VAL 21248
LEU 21180
 None
 1.15A 5ienB-5zvs2:
undetectable		 5ienB-5zvs2:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d85 PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT ALPHA

(Bos taurus) 		no annotation 5 ILE B 294
LEU B 244
VAL B 197
PRO B 199
LEU B 250
 None
 1.17A 5ienB-6d85B:
undetectable		 5ienB-6d85B:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Saccharomyces
cerevisiae) 		no annotation 5 LEU U  69
VAL U 177
ILE U 173
LEU U 175
LEU U  23
 None
 1.18A 5ienB-6ezmU:
undetectable		 5ienB-6ezmU:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fpc PRO-PRO
ENDOPEPTIDASE

(Paenibacillus
alvei) 		no annotation 5 LEU A  36
VAL A 143
ILE A 136
LEU A 140
LEU A  76
 None
 1.19A 5ienB-6fpcA:
undetectable		 5ienB-6fpcA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gdg TRXA,ADENOSINE
RECEPTOR A2A

(Escherichia
coli;
Homo sapiens) 		no annotation 5 ILE A 127
LEU A 131
VAL A 188
ILE A 100
LEU A 192
 None
 1.02A 5ienB-6gdgA:
undetectable		 5ienB-6gdgA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exb KV BETA2 PROTEIN

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		5 LEU A 340
LEU A 303
LEU A 343
ILE A 354
LEU A 355
 None
 1.04A 5ienB-1exbA:
undetectable		 5ienB-1exbA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gmi PROTEIN KINASE C,
EPSILON TYPE

(Rattus rattus) 		PF00168
(C2) 		5 LEU A  38
TRP A  65
LEU A  18
ILE A 117
ALA A  82
 None
 1.22A 5ienB-1gmiA:
0.0		 5ienB-1gmiA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		5 LEU A 499
LEU A 601
LEU A 500
THR A 568
ALA A 564
 None
 1.07A 5ienB-1kehA:
undetectable		 5ienB-1kehA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpc DIANTHIN 30

(Dianthus
caryophyllus) 		PF00161
(RIP) 		5 LEU A   8
PHE A  56
LEU A  67
LEU A   6
ALA A 178
 None
 1.21A 5ienB-1lpcA:
undetectable		 5ienB-1lpcA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p50 ARGININE KINASE

(Limulus
polyphemus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 LEU A 110
MET A 352
LEU A 239
ILE A 325
LEU A 306
 None
 1.20A 5ienB-1p50A:
0.0		 5ienB-1p50A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyf IOLS PROTEIN

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		5 LEU A 180
LEU A 276
ILE A 262
ALA A 269
LEU A 297
 None
 1.22A 5ienB-1pyfA:
0.0		 5ienB-1pyfA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 95 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08519
(RFC1) 		5 TRP A 323
LEU A 324
LEU A 453
ILE A 374
THR A 447
 None
 1.20A 5ienB-1sxjA:
0.0		 5ienB-1sxjA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2a GLUTATHIONE
TRANSFERASE GST1-6

(Anopheles dirus) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 LEU A  17
TRP A 180
LEU A 135
ILE A 107
LEU A 164
 None
 1.15A 5ienB-1v2aA:
0.0		 5ienB-1v2aA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqr HYPOTHETICAL PROTEIN
CJ0248

(Campylobacter
jejuni) 		PF08668
(HDOD) 		5 LEU A 114
LEU A  19
ILE A  86
ALA A  54
LEU A  56
 None
 1.24A 5ienB-1vqrA:
undetectable		 5ienB-1vqrA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp4 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Streptococcus
pneumoniae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 LEU A  90
ILE A  99
GLU A 135
THR A 159
ALA A 124
 None
 1.22A 5ienB-1xp4A:
undetectable		 5ienB-1xp4A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl0 HYPOTHETICAL PROTEIN
PA5198

(Pseudomonas
aeruginosa) 		PF02016
(Peptidase_S66) 		5 LEU A 196
LEU A  98
TYR A 294
ALA A 131
LEU A 129
 None
 1.11A 5ienB-1zl0A:
undetectable		 5ienB-1zl0A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		6 LEU A 461
PHE A 458
LEU A 468
ILE A 379
ALA A 531
LEU A 528
 None
 1.48A 5ienB-2ag1A:
undetectable		 5ienB-2ag1A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		5 LEU A 135
ILE A 120
TYR A 179
ALA A 173
LEU A 171
 None
 1.13A 5ienB-2azkA:
undetectable		 5ienB-2azkA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdq ASPARTOKINASE

(Arabidopsis
thaliana) 		PF00696
(AA_kinase) 		5 LEU A 119
ILE A 211
THR A  69
ALA A  65
LEU A  63
 None
None
None
LYS  A 601 (-3.9A)
None
 1.15A 5ienB-2cdqA:
undetectable		 5ienB-2cdqA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfi PHYTASE

(Debaryomyces
castellii) 		PF00328
(His_Phos_2) 		5 LEU A 248
ILE A 277
TYR A  90
GLU A  91
LEU A 258
 None
 1.24A 5ienB-2gfiA:
0.0		 5ienB-2gfiA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 361
MET A 359
LEU A 242
ALA A 371
LEU A 399
 None
 1.02A 5ienB-2gpvA:
undetectable		 5ienB-2gpvA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 LEU A 300
LEU A 274
LEU A 296
ILE A 435
ALA A 407
 None
 1.15A 5ienB-2h2qA:
undetectable		 5ienB-2h2qA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8i NP275

(Nostoc
punctiforme) 		PF00805
(Pentapeptide) 		5 LEU A  82
MET A   1
ILE A  30
ALA A  55
LEU A  32
 None
 0.95A 5ienB-2j8iA:
undetectable		 5ienB-2j8iA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8k NP275-NP276

(Nostoc
punctiforme) 		PF00805
(Pentapeptide) 		5 LEU A  82
MET A   1
ILE A  30
ALA A  55
LEU A  32
 None
 0.89A 5ienB-2j8kA:
undetectable		 5ienB-2j8kA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8k NP275-NP276

(Nostoc
punctiforme) 		PF00805
(Pentapeptide) 		6 LEU A  87
MET A   1
LEU A  67
ILE A  30
ALA A  55
LEU A  32
 None
 1.49A 5ienB-2j8kA:
undetectable		 5ienB-2j8kA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyz HYPOTHETICAL PROTEIN
GAMMAHV.M3

(Murid
gammaherpesvirus
4) 		PF09213
(M3) 		5 LEU A  55
ILE A  26
GLU A 197
THR A 183
LEU A  65
 None
 1.03A 5ienB-2nyzA:
undetectable		 5ienB-2nyzA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1e YCDH

(Bacillus
subtilis) 		PF01297
(ZnuA) 		5 LEU A 131
LEU A 291
ILE A 283
TYR A 239
THR A 190
 None
 0.88A 5ienB-2o1eA:
undetectable		 5ienB-2o1eA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1e YCDH

(Bacillus
subtilis) 		PF01297
(ZnuA) 		5 LEU A 295
LEU A 131
LEU A 291
ILE A 283
TYR A 239
 None
 1.20A 5ienB-2o1eA:
undetectable		 5ienB-2o1eA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN

(Cyanothece) 		PF00805
(Pentapeptide) 		6 LEU A  97
LEU A 117
ILE A 165
THR A 110
ALA A 130
LEU A 147
 None
 0.99A 5ienB-2o6wA:
undetectable		 5ienB-2o6wA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		5 LEU A  31
LEU A 149
ILE A 186
ALA A 271
LEU A 267
 GRG  A 500 (-4.3A)
None
None
None
None
 1.11A 5ienB-2q80A:
undetectable		 5ienB-2q80A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN

(Bacillus cereus) 		PF05139
(Erythro_esteras) 		5 LEU A 426
LEU A  79
MET A 302
ILE A  71
LEU A  67
 None
 1.15A 5ienB-2qgmA:
undetectable		 5ienB-2qgmA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qza SECRETED EFFECTOR
PROTEIN

(Salmonella
enterica) 		PF13599
(Pentapeptide_4)
PF13979
(SopA_C)
PF13981
(SopA) 		5 LEU A 273
LEU A 241
LEU A 253
ILE A 205
THR A 279
 None
 1.22A 5ienB-2qzaA:
undetectable		 5ienB-2qzaA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w87 ESTERASE D

(Cellvibrio
japonicus) 		PF03422
(CBM_6) 		5 ILE A  65
GLU A 126
THR A 124
ALA A 122
LEU A 120
 None
 1.20A 5ienB-2w87A:
undetectable		 5ienB-2w87A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		5 LEU A 806
LEU A 830
THR A 820
ALA A 844
LEU A 870
 None
 1.17A 5ienB-2wfhA:
undetectable		 5ienB-2wfhA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpa UNCHARACTERIZED
PROTEIN YPFI

(Escherichia
coli) 		PF05127
(Helicase_RecD)
PF08351
(DUF1726)
PF13718
(GNAT_acetyltr_2)
PF17176
(tRNA_bind_3) 		5 LEU A 500
PHE A 503
LEU A 476
ALA A 376
LEU A 373
 ACO  A 700 ( 4.6A)
ACO  A 700 (-3.8A)
None
ACO  A 700 ( 4.5A)
None
 1.24A 5ienB-2zpaA:
undetectable		 5ienB-2zpaA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwn L-TRYPTOPHAN
AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF04864
(Alliinase_C) 		5 LEU A 212
LEU A  65
LEU A 103
ILE A 245
ALA A 110
 None
 0.90A 5ienB-3bwnA:
undetectable		 5ienB-3bwnA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzm MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Escherichia
coli) 		PF00425
(Chorismate_bind) 		5 LEU A  83
PHE A  82
LEU A  92
ILE A  28
LEU A 125
 None
 1.21A 5ienB-3bzmA:
undetectable		 5ienB-3bzmA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du1 ALL3740 PROTEIN

(Nostoc sp. PCC
7120) 		PF00805
(Pentapeptide) 		5 LEU X  42
LEU X  62
THR X  55
ALA X  75
LEU X  92
 None
 1.15A 5ienB-3du1X:
undetectable		 5ienB-3du1X:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du1 ALL3740 PROTEIN

(Nostoc sp. PCC
7120) 		PF00805
(Pentapeptide) 		5 LEU X  82
LEU X 102
THR X  95
ALA X 115
LEU X 137
 None
 1.00A 5ienB-3du1X:
undetectable		 5ienB-3du1X:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1s EXODEOXYRIBONUCLEASE
V, SUBUNIT RECD

(Deinococcus
radiodurans) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30)
PF14490
(HHH_4) 		5 LEU A 311
LEU A 449
ILE A 433
ALA A 456
LEU A 431
 None
 1.12A 5ienB-3e1sA:
undetectable		 5ienB-3e1sA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Francisella
tularensis) 		PF02540
(NAD_synthase) 		5 ILE A  90
TYR A  86
GLU A  84
THR A  57
LEU A  61
 None
None
None
None
AMP  A3001 (-4.2A)
 1.19A 5ienB-3fiuA:
undetectable		 5ienB-3fiuA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ged SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Ruminiclostridium
thermocellum) 		PF13561
(adh_short_C2) 		5 LEU A  62
PHE A  65
LEU A 113
ILE A 129
ALA A  83
 None
None
None
None
THJ  A 249 ( 4.1A)
 1.19A 5ienB-3gedA:
undetectable		 5ienB-3gedA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glg DNA POLYMERASE III
SUBUNIT DELTA'

(Escherichia
coli) 		PF09115
(DNApol3-delta_C)
PF13177
(DNA_pol3_delta2) 		5 LEU E 286
TRP E 229
LEU E 316
LEU E 252
LEU E 216
 None
 1.22A 5ienB-3glgE:
undetectable		 5ienB-3glgE:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2

(Trypanosoma
brucei) 		PF01704
(UDPGP) 		5 LEU A 396
LEU A  97
LEU A 222
ALA A 111
LEU A 129
 None
 1.13A 5ienB-3gueA:
undetectable		 5ienB-3gueA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op1 MACROLIDE-EFFLUX
PROTEIN

(Streptococcus
pneumoniae) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		5 PHE A 102
LEU A  23
LEU A  96
THR A 113
ALA A 117
 None
GOL  A 318 ( 4.5A)
None
None
None
 1.22A 5ienB-3op1A:
undetectable		 5ienB-3op1A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvo C-REACTIVE PROTEIN

(Homo sapiens) 		PF00354
(Pentaxin) 		5 LEU A 190
MET A   4
ILE A 156
TYR A  54
LEU A 135
 None
 1.22A 5ienB-3pvoA:
undetectable		 5ienB-3pvoA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q13 SPONDIN-1

(Homo sapiens) 		PF06468
(Spond_N) 		5 LEU A 262
ILE A 235
THR A 357
ALA A 355
LEU A 317
 None
 1.23A 5ienB-3q13A:
undetectable		 5ienB-3q13A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		5 LEU A 298
LEU A 277
ILE A 191
ALA A  56
LEU A  53
 None
 1.23A 5ienB-3q1oA:
undetectable		 5ienB-3q1oA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvl PUTATIVE HYDANTOIN
RACEMASE

(Klebsiella
pneumoniae) 		PF01177
(Asp_Glu_race) 		5 LEU A 237
PHE A 241
LEU A 244
ILE A   9
ALA A  87
 None
 1.18A 5ienB-3qvlA:
undetectable		 5ienB-3qvlA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6p CAPSID PROTEIN

(Helicoverpa
armigera stunt
virus) 		PF03566
(Peptidase_A21) 		5 LEU A 493
ILE A 218
TYR A 408
THR A 290
ALA A 407
 None
 1.23A 5ienB-3s6pA:
undetectable		 5ienB-3s6pA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tat TYROSINE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 LEU A 284
LEU A  95
ILE A 240
GLU A  74
LEU A  87
 None
 1.21A 5ienB-3tatA:
undetectable		 5ienB-3tatA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 LEU A  98
MET A  96
LEU A 153
ILE A 182
LEU A 177
 None
 1.22A 5ienB-3u1kA:
undetectable		 5ienB-3u1kA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b45 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		5 LEU A   5
PHE A  98
LEU A 225
LEU A  19
ALA A 195
 None
 1.19A 5ienB-4b45A:
undetectable		 5ienB-4b45A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF01839
(FG-GAP)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF08441
(Integrin_alpha2)
PF17205
(PSI_integrin) 		5 LEU B 262
LEU A 322
ILE B 325
TYR A 288
THR A 263
 None
 1.23A 5ienB-4cakB:
undetectable		 5ienB-4cakB:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cj0 ENDOGLUCANASE D

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		5 LEU A 245
PHE A 244
LEU A 248
ILE A 211
LEU A 406
 None
 1.11A 5ienB-4cj0A:
undetectable		 5ienB-4cj0A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpo CONSERVED PROTEIN

(Methanosarcina
mazei) 		PF03992
(ABM) 		5 PHE A  73
LEU A  64
LEU A  27
THR A  88
ALA A   8
 None
 1.15A 5ienB-4dpoA:
1.8		 5ienB-4dpoA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewg BETA-KETOACYL
SYNTHASE

(Paraburkholderia
phymatum) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		6 LEU A 402
ILE A   6
TYR A 105
THR A 160
ALA A 104
LEU A 240
 None
 1.19A 5ienB-4ewgA:
undetectable		 5ienB-4ewgA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 LEU A 569
ILE A 562
GLU A 508
ALA A 549
LEU A 597
 None
 1.04A 5ienB-4fddA:
undetectable		 5ienB-4fddA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 204
ILE A 263
GLU A 459
THR A 319
LEU A 227
 None
None
None
HEM  A 601 (-4.6A)
None
 1.05A 5ienB-4fdhA:
undetectable		 5ienB-4fdhA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 LEU A 398
LEU A 484
LEU A 504
THR A 512
LEU A 521
 None
 1.22A 5ienB-4fysA:
2.0		 5ienB-4fysA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gou EHRGS-RHOGEF

(Entamoeba
histolytica) 		PF00615
(RGS)
PF00621
(RhoGEF) 		5 TRP A  13
LEU A 132
ILE A 365
TYR A 271
LEU A 369
 None
 1.12A 5ienB-4gouA:
undetectable		 5ienB-4gouA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		5 TRP C 366
LEU C 369
ILE C 419
ALA C 343
LEU C 340
 None
 1.20A 5ienB-4hb4C:
undetectable		 5ienB-4hb4C:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jj9 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE

(Bordetella
bronchiseptica) 		PF02962
(CHMI) 		5 LEU A 110
LEU A 107
ILE A  99
ALA A  50
LEU A   4
 None
 1.23A 5ienB-4jj9A:
undetectable		 5ienB-4jj9A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ltm NADH-DEPENDENT FMN
REDUCTASE

(EDTA-degrading
bacterium BNC1) 		PF03358
(FMN_red) 		5 LEU A  55
LEU A  60
ILE A  43
ALA A  90
LEU A  87
 None
 1.19A 5ienB-4ltmA:
undetectable		 5ienB-4ltmA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maa PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		5 LEU A 225
MET A 250
LEU A 183
ILE A 198
TYR A 202
 None
 1.23A 5ienB-4maaA:
undetectable		 5ienB-4maaA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgq GLYCOSYL HYDROLASE
FAMILY 10

(Prevotella
bryantii) 		PF02018
(CBM_4_9) 		5 LEU A 255
TRP A 276
LEU A 154
LEU A 186
LEU A 241
 None
 1.00A 5ienB-4mgqA:
undetectable		 5ienB-4mgqA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nav HYPOTHETICAL PROTEIN
XCC279

(Xanthomonas
campestris) 		no annotation 5 LEU D 126
ILE D  64
THR D  30
ALA D 159
LEU D  59
 None
 1.22A 5ienB-4navD:
undetectable		 5ienB-4navD:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzr PROTEIN M TD

(Mycoplasma
genitalium) 		no annotation 5 LEU M 169
LEU M 292
ILE M 305
THR M 243
LEU M 281
 None
 1.18A 5ienB-4nzrM:
undetectable		 5ienB-4nzrM:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		6 PHE A 336
LEU A 358
ILE A 422
TYR A  82
GLU A  78
ALA A 416
 None
None
None
ACT  A 703 (-4.8A)
None
None
 1.24A 5ienB-4qjyA:
undetectable		 5ienB-4qjyA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A1050
LEU A 944
LEU A1047
ILE A 913
TYR A 988
 None
 1.09A 5ienB-4qpmA:
undetectable		 5ienB-4qpmA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsx TYPE III EFFECTOR
HOPA1

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 LEU A 174
LEU A 248
LEU A 177
ILE A 256
TYR A 219
 None
 1.23A 5ienB-4rsxA:
undetectable		 5ienB-4rsxA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvm CITRATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00285
(Citrate_synt) 		5 LEU A 120
LEU A 392
LEU A 116
ILE A 110
TYR A 148
 None
 1.18A 5ienB-4tvmA:
undetectable		 5ienB-4tvmA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u GLOBIN C CHAIN

(Glossoscolex
paulistus) 		PF00042
(Globin) 		5 PHE C 111
LEU C  38
LEU C 142
ALA C  75
LEU C  73
 HEM  C 201 (-3.7A)
CYN  C 202 (-4.7A)
HEM  C 201 (-4.8A)
HEM  C 201 (-3.6A)
None
 1.06A 5ienB-4u8uC:
3.5		 5ienB-4u8uC:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yei BETA1MUT

(synthetic
construct) 		PF00805
(Pentapeptide) 		5 LEU A  42
MET A  21
LEU A  87
ALA A  75
LEU A  52
 None
 1.18A 5ienB-4yeiA:
undetectable		 5ienB-4yeiA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zev PFHAD1

(Plasmodium
falciparum) 		PF08282
(Hydrolase_3) 		5 LEU A 208
ILE A 124
TYR A 148
GLU A 152
LEU A 176
 None
None
M6P  A 302 ( 4.9A)
M6P  A 302 (-2.2A)
None
 1.20A 5ienB-4zevA:
undetectable		 5ienB-4zevA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 LEU A 113
PHE A 112
LEU A 847
TYR A 838
LEU A 878
 None
 1.18A 5ienB-5a22A:
undetectable		 5ienB-5a22A:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2a APO FORM OF
ANOXYBACILLUS
ALPHA-AMYLASES

(Anoxybacillus
ayderensis) 		PF00128
(Alpha-amylase) 		5 LEU A 445
LEU A 306
ILE A 274
ALA A 339
LEU A 285
 None
 1.21A 5ienB-5a2aA:
2.9		 5ienB-5a2aA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		5 MET A1177
TYR A1294
GLU A1276
ALA A1297
LEU A1603
 None
 1.03A 5ienB-5a31A:
2.5		 5ienB-5a31A:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqk ICP27

(Human
alphaherpesvirus
1) 		PF05459
(Herpes_UL69) 		5 LEU A 407
LEU A 390
LEU A 402
ILE A 495
LEU A 476
 None
 1.12A 5ienB-5bqkA:
undetectable		 5ienB-5bqkA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bth DECAPPING NUCLEASE
RAI1

(Candida
albicans) 		PF08652
(RAI1) 		5 LEU A   7
TRP A 334
LEU A 335
ILE A 105
LEU A 122
 None
 1.24A 5ienB-5bthA:
undetectable		 5ienB-5bthA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz4 BETA-KETOTHIOLASE

(Mycolicibacterium
smegmatis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A  77
LEU A  55
ILE A 266
ALA A  35
LEU A  39
 None
 1.19A 5ienB-5bz4A:
undetectable		 5ienB-5bz4A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8

(Homo sapiens) 		PF00005
(ABC_tran)
PF01061
(ABC2_membrane) 		5 LEU A 575
PHE A 502
LEU A 423
ILE B 578
THR A 430
 None
 1.13A 5ienB-5do7A:
undetectable		 5ienB-5do7A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		5 LEU A 371
LEU A  65
MET A  68
ILE A  46
ALA A  18
 None
None
None
FAD  A 401 (-4.6A)
None
 1.16A 5ienB-5eowA:
undetectable		 5ienB-5eowA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evl BETA-LACTAMASE

(Chromobacterium
violaceum) 		PF00144
(Beta-lactamase) 		5 LEU A 183
LEU A 269
LEU A 179
ALA A  80
LEU A  84
 None
 1.08A 5ienB-5evlA:
undetectable		 5ienB-5evlA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foi MYCINAMICIN VIII C21
METHYL HYDROXYLASE

(Micromonospora
griseorubida) 		PF00067
(p450) 		5 LEU A 223
LEU A  80
THR A 231
ALA A 274
LEU A 302
 MY8  A 414 (-4.0A)
HEM  A 413 ( 3.7A)
HEM  A 413 (-3.6A)
HEM  A 413 (-3.6A)
None
 1.13A 5ienB-5foiA:
undetectable		 5ienB-5foiA:
16.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ieo CDL2.3A

(synthetic
construct) 		PF14534
(DUF4440) 		7 LEU A  12
PHE A  15
ILE A 100
TYR A 104
GLU A 106
THR A 121
ALA A 123
 VDY  A 206 ( 4.3A)
VDY  A 206 (-3.5A)
VDY  A 206 (-2.9A)
VDY  A 206 ( 2.8A)
VDY  A 206 (-2.4A)
VDY  A 206 (-3.4A)
VDY  A 206 ( 3.1A)
 0.71A 5ienB-5ieoA:
22.7		 5ienB-5ieoA:
91.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ieo CDL2.3A

(synthetic
construct) 		PF14534
(DUF4440) 		7 LEU A  12
PHE A  15
LEU A  54
ILE A 100
TYR A 104
GLU A 106
ALA A 123
 VDY  A 206 ( 4.3A)
VDY  A 206 (-3.5A)
VDY  A 206 ( 3.9A)
VDY  A 206 (-2.9A)
VDY  A 206 ( 2.8A)
VDY  A 206 (-2.4A)
VDY  A 206 ( 3.1A)
 1.34A 5ienB-5ieoA:
22.7		 5ienB-5ieoA:
91.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ieo CDL2.3A

(synthetic
construct) 		PF14534
(DUF4440) 		9 LEU A  12
PHE A  15
TRP A  55
LEU A  58
MET A  61
TYR A 104
GLU A 106
THR A 121
ALA A 123
 VDY  A 206 ( 4.3A)
VDY  A 206 (-3.5A)
VDY  A 206 ( 4.4A)
VDY  A 206 ( 4.7A)
VDY  A 206 ( 3.1A)
VDY  A 206 ( 2.8A)
VDY  A 206 (-2.4A)
VDY  A 206 (-3.4A)
VDY  A 206 ( 3.1A)
 0.42A 5ienB-5ieoA:
22.7		 5ienB-5ieoA:
91.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqk PEPTIDASE, PUTATIVE

(Plasmodium
falciparum) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 LEU A 366
PHE A 367
LEU A 347
ILE A 452
LEU A 343
 None
 1.20A 5ienB-5jqkA:
1.2		 5ienB-5jqkA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kem BDBV91 VARIABLE FAB
DOMAIN HEAVY CHAIN

(Homo sapiens) 		PF07686
(V-set) 		5 LEU B  82
LEU B  82
ILE B  51
TYR B  90
THR B 107
 None
 1.06A 5ienB-5kemB:
undetectable		 5ienB-5kemB:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans) 		no annotation 5 PHE B 541
TRP B 661
LEU B 669
GLU B 503
ALA B 505
 None
 1.08A 5ienB-5khnB:
undetectable		 5ienB-5khnB:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6

(Bos taurus) 		PF00146
(NADHdh)
PF00420
(Oxidored_q2)
PF00499
(Oxidored_q3) 		5 LEU H 100
PHE H 160
LEU H 103
ILE J  59
LEU K  64
 None
 1.13A 5ienB-5lc5H:
undetectable		 5ienB-5lc5H:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		5 MET A1177
TYR A1294
GLU A1276
ALA A1297
LEU A1603
 None
 1.00A 5ienB-5lcwA:
undetectable		 5ienB-5lcwA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER

(Prochlorococcus
marinus) 		no annotation 5 LEU A 117
LEU A 175
LEU A 114
ILE A 199
LEU A 196
 None
 1.15A 5ienB-5lq8A:
undetectable		 5ienB-5lq8A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC

(Flaveria
trinervia) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		5 LEU A 269
LEU A 292
ILE A 275
TYR A 303
ALA A 302
 None
 1.06A 5ienB-5lu4A:
undetectable		 5ienB-5lu4A:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-) 		no annotation 5 LEU A 275
LEU A 384
ILE A 502
GLU A 224
THR A 158
 None
 1.05A 5ienB-5mz9A:
4.5		 5ienB-5mz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvh OCTOPINE
CATABOLISM/UPTAKE
OPERON REGULATORY
PROTEIN OCCR

(Agrobacterium
tumefaciens) 		PF03466
(LysR_substrate) 		5 LEU A 162
MET A 297
LEU A 225
ALA A 100
LEU A 105
 None
 1.17A 5ienB-5vvhA:
undetectable		 5ienB-5vvhA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2

(Leptotrichia
shahii) 		no annotation 5 PHE A1340
LEU A1331
LEU A1342
ILE A1375
THR A1317
 None
 1.18A 5ienB-5wtkA:
undetectable		 5ienB-5wtkA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 5 MET A 778
LEU A 559
ILE A 815
ALA A 824
LEU A 819
 None
 1.15A 5ienB-5wugA:
1.8		 5ienB-5wugA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A

(Oryzias latipes) 		PF01094
(ANF_receptor) 		5 LEU A 406
LEU A  39
ILE A 151
ALA A 133
LEU A 114
 None
 1.18A 5ienB-5x2qA:
undetectable		 5ienB-5x2qA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbk IMPORTIN-4

(Homo sapiens) 		no annotation 5 LEU D1008
PHE D1005
LEU D 991
ILE D 961
LEU D 949
 None
 1.21A 5ienB-5xbkD:
undetectable		 5ienB-5xbkD:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xev XAA-PRO
DIPEPTIDASE,PEPTIDAS
E-RELATED PROTEIN

(Deinococcus
radiodurans) 		no annotation 5 LEU A 393
LEU A 382
GLU A 278
ALA A 280
LEU A 336
 None
 1.09A 5ienB-5xevA:
undetectable		 5ienB-5xevA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aun PLA2G6, IPLA2BETA

(Cricetulus
griseus) 		no annotation 5 LEU A 470
LEU A 457
LEU A 429
ILE A 635
LEU A 745
 None
 1.19A 5ienB-6aunA:
undetectable		 5ienB-6aunA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fv5 QUEUINE
TRNA-RIBOSYLTRANSFER
ASE ACCESSORY
SUBUNIT 2

(Mus musculus) 		no annotation 5 LEU A  64
PHE A 129
LEU A 171
LEU A  96
ILE A 193
 None
 1.17A 5ienB-6fv5A:
undetectable		 5ienB-6fv5A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gqd GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Homo sapiens) 		no annotation 6 PHE A 131
TRP A 154
LEU A 139
ILE A 278
TYR A 296
LEU A 255
 None
 1.28A 5ienB-6gqdA:
undetectable		 5ienB-6gqdA:
undetectable