SIMILAR PATTERNS OF AMINO ACIDS FOR 5ICX_F_SC2F1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0z THIS PROTEIN

(Escherichia
coli) 		PF02597
(ThiS) 		3 VAL A  51
GLN A   2
CYH A  12
 None
 0.88A 5icxC-1f0zA:
0.0
5icxF-1f0zA:
undetectable		 5icxC-1f0zA:
14.88
5icxF-1f0zA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbz DTDP-GLUCOSE
OXIDOREDUCTASE

(Salmonella
enterica) 		PF04321
(RmlD_sub_bind) 		3 VAL A  99
GLN A 140
CYH A 143
 None
 0.87A 5icxC-1kbzA:
undetectable
5icxF-1kbzA:
undetectable		 5icxC-1kbzA:
21.40
5icxF-1kbzA:
3.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE

(Escherichia
coli) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		3 VAL A 144
GLN A 205
CYH A 208
 SF4  A 300 ( 4.4A)
None
SF4  A 300 (-2.3A)
 0.83A 5icxC-1kqjA:
undetectable
5icxF-1kqjA:
undetectable		 5icxC-1kqjA:
19.01
5icxF-1kqjA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2u OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Escherichia
coli) 		PF00215
(OMPdecase) 		3 VAL A 215
GLN A 171
CYH A 168
 None
 0.64A 5icxC-1l2uA:
undetectable
5icxF-1l2uA:
undetectable		 5icxC-1l2uA:
21.33
5icxF-1l2uA:
5.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lc0 BILIVERDIN REDUCTASE
A

(Rattus
norvegicus) 		PF01408
(GFO_IDH_MocA)
PF09166
(Biliv-reduc_cat) 		3 VAL A 202
GLN A 288
CYH A 291
 None
 0.85A 5icxC-1lc0A:
undetectable
5icxF-1lc0A:
undetectable		 5icxC-1lc0A:
23.66
5icxF-1lc0A:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzd COATOMER GAMMA
SUBUNIT

(Bos taurus) 		PF08752
(COP-gamma_platf)
PF16381
(Coatomer_g_Cpla) 		3 VAL A 679
GLN A 662
CYH A 665
 None
 0.79A 5icxC-1pzdA:
0.0
5icxF-1pzdA:
undetectable		 5icxC-1pzdA:
21.67
5icxF-1pzdA:
4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4x COATOMER GAMMA
SUBUNIT

(Homo sapiens) 		PF08752
(COP-gamma_platf)
PF16381
(Coatomer_g_Cpla) 		3 VAL A 679
GLN A 662
CYH A 665
 None
 0.77A 5icxC-1r4xA:
0.0
5icxF-1r4xA:
undetectable		 5icxC-1r4xA:
22.30
5icxF-1r4xA:
4.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlf PEROXISOME
BIOGENESIS FACTOR 1

(Mus musculus) 		PF09262
(PEX-1N)
PF09263
(PEX-2N) 		3 VAL A 137
GLN A 105
CYH A 103
 None
 0.58A 5icxC-1wlfA:
0.0
5icxF-1wlfA:
undetectable		 5icxC-1wlfA:
21.60
5icxF-1wlfA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9s DNA POLYMERASE

(Escherichia
virus T7) 		PF00476
(DNA_pol_A) 		3 VAL A 669
GLN A 471
CYH A 660
 None
 0.83A 5icxC-1x9sA:
0.0
5icxF-1x9sA:
undetectable		 5icxC-1x9sA:
15.32
5icxF-1x9sA:
2.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xm9 PLAKOPHILIN 1

(Homo sapiens) 		PF00514
(Arm) 		3 VAL A 283
GLN A 270
CYH A 273
 None
 0.58A 5icxC-1xm9A:
undetectable
5icxF-1xm9A:
undetectable		 5icxC-1xm9A:
19.29
5icxF-1xm9A:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqb HYPOTHETICAL UPF0066
PROTEIN HI0510

(Haemophilus
influenzae) 		PF01980
(UPF0066) 		3 VAL A  48
GLN A 109
CYH A 112
 None
 0.72A 5icxC-1xqbA:
0.1
5icxF-1xqbA:
undetectable		 5icxC-1xqbA:
21.74
5icxF-1xqbA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1f URIDYLATE KINASE

(Haemophilus
influenzae) 		PF00696
(AA_kinase) 		3 VAL A  82
GLN A 106
CYH A 111
 None
 0.83A 5icxC-2a1fA:
undetectable
5icxF-2a1fA:
undetectable		 5icxC-2a1fA:
20.30
5icxF-2a1fA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS

(Mus musculus) 		PF01494
(FAD_binding_3) 		3 VAL A 406
GLN A 161
CYH A  95
 None
None
FAD  A1485 (-3.5A)
 0.90A 5icxC-2braA:
undetectable
5icxF-2braA:
undetectable		 5icxC-2braA:
18.38
5icxF-2braA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7s RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE KAPPA

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 VAL A1068
GLN A1043
CYH A 981
 None
 0.76A 5icxC-2c7sA:
undetectable
5icxF-2c7sA:
undetectable		 5icxC-2c7sA:
18.69
5icxF-2c7sA:
3.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efj 3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		3 VAL A  71
GLN A  95
CYH A 131
 None
 0.60A 5icxC-2efjA:
undetectable
5icxF-2efjA:
undetectable		 5icxC-2efjA:
19.79
5icxF-2efjA:
3.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg5 XANTHOSINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		3 VAL A  72
GLN A  96
CYH A 132
 None
 0.55A 5icxC-2eg5A:
undetectable
5icxF-2eg5A:
undetectable		 5icxC-2eg5A:
19.79
5icxF-2eg5A:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE

(Pseudomonas
aeruginosa) 		PF00682
(HMGL-like) 		3 VAL A 234
GLN A 278
CYH A 281
 None
 0.68A 5icxC-2ftpA:
undetectable
5icxF-2ftpA:
undetectable		 5icxC-2ftpA:
20.06
5icxF-2ftpA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM

(Rhodobacter
sphaeroides) 		PF03480
(DctP) 		3 VAL A 168
GLN A 307
CYH A 309
 None
 0.90A 5icxC-2hzkA:
undetectable
5icxF-2hzkA:
undetectable		 5icxC-2hzkA:
19.73
5icxF-2hzkA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		3 VAL A 774
GLN A 739
CYH A 741
 None
 0.85A 5icxC-2jgdA:
undetectable
5icxF-2jgdA:
undetectable		 5icxC-2jgdA:
12.68
5icxF-2jgdA:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jw6 DEFORMED EPIDERMAL
AUTOREGULATORY
FACTOR 1 HOMOLOG

(Homo sapiens) 		PF01753
(zf-MYND) 		3 VAL A 521
GLN A 537
CYH A 540
 None
None
ZN  A 602 (-2.3A)
 0.73A 5icxC-2jw6A:
undetectable
5icxF-2jw6A:
undetectable		 5icxC-2jw6A:
11.36
5icxF-2jw6A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzj GTP-BINDING PROTEIN
REM 1

(Homo sapiens) 		PF00071
(Ras) 		3 VAL A 133
GLN A 147
CYH A 150
 None
 0.76A 5icxC-2nzjA:
undetectable
5icxF-2nzjA:
undetectable		 5icxC-2nzjA:
21.03
5icxF-2nzjA:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4f HISTIDINE-CONTAINING
PHOSPHOTRANSFER
PROTEIN 1

(Oryza sativa) 		PF01627
(Hpt) 		3 VAL A  79
GLN A 103
CYH A 105
 None
 0.88A 5icxC-2q4fA:
undetectable
5icxF-2q4fA:
undetectable		 5icxC-2q4fA:
20.77
5icxF-2q4fA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgn RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 25

(Homo sapiens) 		PF00621
(RhoGEF) 		3 VAL B 292
GLN B 254
CYH B 333
 None
 0.79A 5icxC-2rgnB:
undetectable
5icxF-2rgnB:
undetectable		 5icxC-2rgnB:
21.69
5icxF-2rgnB:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rr7 DYNEIN HEAVY CHAIN 9

(Chlamydomonas
reinhardtii) 		PF12777
(MT) 		3 VAL A  31
GLN A 121
CYH A 125
 None
 0.89A 5icxC-2rr7A:
undetectable
5icxF-2rr7A:
undetectable		 5icxC-2rr7A:
21.97
5icxF-2rr7A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v3b RUBREDOXIN 2

(Pseudomonas
aeruginosa) 		PF00301
(Rubredoxin) 		3 VAL B  44
GLN B   5
CYH B   9
 None
None
FE  B1054 (-2.3A)
 0.91A 5icxC-2v3bB:
undetectable
5icxF-2v3bB:
undetectable		 5icxC-2v3bB:
13.08
5icxF-2v3bB:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wab ENDOGLUCANASE E

(Ruminiclostridium
thermocellum) 		PF00657
(Lipase_GDSL) 		3 VAL A  34
GLN A 103
CYH A  27
 None
 0.81A 5icxC-2wabA:
2.7
5icxF-2wabA:
undetectable		 5icxC-2wabA:
20.22
5icxF-2wabA:
3.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwu IMPORTIN13

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1) 		3 VAL B 790
GLN B 780
CYH B 821
 None
 0.82A 5icxC-2xwuB:
undetectable
5icxF-2xwuB:
undetectable		 5icxC-2xwuB:
12.99
5icxF-2xwuB:
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6v PEROXISOMAL MEMBRANE
PROTEIN LPX1

(Saccharomyces
cerevisiae) 		PF12697
(Abhydrolase_6) 		3 VAL A 141
GLN A 158
CYH A 154
 None
 0.88A 5icxC-2y6vA:
undetectable
5icxF-2y6vA:
undetectable		 5icxC-2y6vA:
18.11
5icxF-2y6vA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x LECTIN-LIKE FOLD
PROTEIN

(Agaricus
bisporus) 		no annotation 3 VAL E  84
GLN E  90
CYH E  92
 None
 0.89A 5icxC-2y9xE:
undetectable
5icxF-2y9xE:
undetectable		 5icxC-2y9xE:
21.15
5icxF-2y9xE:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkx SAM-DEPENDENT
METHYLTRANSFERASE

(Lactobacillus
paracasei) 		PF13649
(Methyltransf_25) 		3 VAL A 104
GLN A  53
CYH A  51
 None
 0.86A 5icxC-3bkxA:
undetectable
5icxF-3bkxA:
undetectable		 5icxC-3bkxA:
19.93
5icxF-3bkxA:
4.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwt PROTEIN PUF4

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		3 VAL A 669
GLN A 654
CYH A 693
 None
 0.47A 5icxC-3bwtA:
undetectable
5icxF-3bwtA:
undetectable		 5icxC-3bwtA:
20.85
5icxF-3bwtA:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqy ANHYDRO-N-ACETYLMURA
MIC ACID KINASE

(Shewanella
oneidensis) 		PF03702
(AnmK) 		3 VAL A 101
GLN A  49
CYH A  52
 None
 0.81A 5icxC-3cqyA:
undetectable
5icxF-3cqyA:
undetectable		 5icxC-3cqyA:
21.04
5icxF-3cqyA:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeg 2-ISOPROPYLMALATE
SYNTHASE

(Cytophaga
hutchinsonii) 		PF00682
(HMGL-like) 		3 VAL A 244
GLN A 224
CYH A 227
 None
 0.66A 5icxC-3eegA:
undetectable
5icxF-3eegA:
undetectable		 5icxC-3eegA:
21.12
5icxF-3eegA:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eq5 SKI-LIKE PROTEIN

(Homo sapiens) 		PF02437
(Ski_Sno) 		3 VAL A 170
GLN A 227
CYH A 230
 None
 0.78A 5icxC-3eq5A:
undetectable
5icxF-3eq5A:
undetectable		 5icxC-3eq5A:
21.23
5icxF-3eq5A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ers TRNA-BINDING PROTEIN
YGJH

(Escherichia
coli) 		PF01588
(tRNA_bind) 		3 VAL X  38
GLN X  44
CYH X  81
 None
 0.91A 5icxC-3ersX:
undetectable
5icxF-3ersX:
undetectable		 5icxC-3ersX:
18.22
5icxF-3ersX:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eup TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Cytophaga
hutchinsonii) 		PF00440
(TetR_N) 		3 VAL A  88
GLN A  77
CYH A  79
 None
 0.91A 5icxC-3eupA:
undetectable
5icxF-3eupA:
undetectable		 5icxC-3eupA:
18.64
5icxF-3eupA:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs3 SYMPLEKIN

(Drosophila
melanogaster) 		PF11935
(DUF3453) 		3 VAL A 104
GLN A  92
CYH A  94
 None
 0.85A 5icxC-3gs3A:
undetectable
5icxF-3gs3A:
undetectable		 5icxC-3gs3A:
21.92
5icxF-3gs3A:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9c METHIONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF09334
(tRNA-synt_1g) 		3 VAL A 463
GLN A 474
CYH A 477
 None
 0.82A 5icxC-3h9cA:
undetectable
5icxF-3h9cA:
undetectable		 5icxC-3h9cA:
18.93
5icxF-3h9cA:
2.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4r CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT

(Mus musculus) 		PF00027
(cNMP_binding)
PF02197
(RIIa) 		3 VAL B 176
GLN B 129
CYH B 132
 None
 0.86A 5icxC-3j4rB:
undetectable
5icxF-3j4rB:
undetectable		 5icxC-3j4rB:
18.91
5icxF-3j4rB:
4.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5z FEM-3 MRNA-BINDING
FACTOR 2

(Caenorhabditis
elegans) 		PF00806
(PUF) 		3 VAL A 347
GLN A 329
CYH A 319
 None
 0.71A 5icxC-3k5zA:
undetectable
5icxF-3k5zA:
undetectable		 5icxC-3k5zA:
20.64
5icxF-3k5zA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k81 MP18 RNA EDITING
COMPLEX PROTEIN

(Trypanosoma
brucei) 		PF00436
(SSB) 		3 VAL C  95
GLN C  46
CYH C  74
 None
 0.68A 5icxC-3k81C:
undetectable
5icxF-3k81C:
undetectable		 5icxC-3k81C:
21.43
5icxF-3k81C:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lki FRUCTOKINASE

(Xylella
fastidiosa) 		PF00294
(PfkB) 		3 VAL A  54
GLN A  62
CYH A  17
 None
 0.78A 5icxC-3lkiA:
undetectable
5icxF-3lkiA:
undetectable		 5icxC-3lkiA:
20.17
5icxF-3lkiA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llm ATP-DEPENDENT RNA
HELICASE A

(Homo sapiens) 		PF00270
(DEAD) 		3 VAL A 563
GLN A 420
CYH A 415
 None
None
ADP  A 565 (-4.8A)
 0.89A 5icxC-3llmA:
undetectable
5icxF-3llmA:
undetectable		 5icxC-3llmA:
22.04
5icxF-3llmA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mz1 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Sinorhizobium
meliloti) 		PF03466
(LysR_substrate) 		3 VAL A 241
GLN A 235
CYH A 160
 None
 0.85A 5icxC-3mz1A:
undetectable
5icxF-3mz1A:
undetectable		 5icxC-3mz1A:
22.26
5icxF-3mz1A:
3.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3noj 4-CARBOXY-4-HYDROXY-
2-OXOADIPATE
ALDOLASE/OXALOACETAT
E DECARBOXYLASE

(Pseudomonas
putida) 		PF03737
(RraA-like) 		3 VAL A  88
GLN A 162
CYH A 159
 None
 0.86A 5icxC-3nojA:
undetectable
5icxF-3nojA:
undetectable		 5icxC-3nojA:
19.18
5icxF-3nojA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyy PUTATIVE
GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM

([Ruminococcus]
gnavus) 		PF01551
(Peptidase_M23) 		3 VAL A 170
GLN A 125
CYH A 275
 None
 0.84A 5icxC-3nyyA:
undetectable
5icxF-3nyyA:
undetectable		 5icxC-3nyyA:
20.08
5icxF-3nyyA:
3.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 VAL A 193
GLN A 384
CYH A 386
 None
 0.87A 5icxC-3oc4A:
undetectable
5icxF-3oc4A:
undetectable		 5icxC-3oc4A:
18.99
5icxF-3oc4A:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE

(Mycobacterium
marinum) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 VAL A  74
GLN A  52
CYH A  95
 None
 0.78A 5icxC-3rv2A:
undetectable
5icxF-3rv2A:
undetectable		 5icxC-3rv2A:
18.18
5icxF-3rv2A:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3siq APOPTOSIS 1
INHIBITOR

(Drosophila
melanogaster) 		PF00653
(BIR) 		3 VAL A  85
GLN A 101
CYH A 107
 None
None
ZN  A 200 (-2.3A)
 0.78A 5icxC-3siqA:
undetectable
5icxF-3siqA:
undetectable		 5icxC-3siqA:
18.64
5icxF-3siqA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3smd MUTT/NUDIX FAMILY
PROTEIN

(Bacillus
thuringiensis) 		PF00293
(NUDIX) 		3 VAL A  66
GLN A  75
CYH A 107
 None
 0.67A 5icxC-3smdA:
undetectable
5icxF-3smdA:
undetectable		 5icxC-3smdA:
22.07
5icxF-3smdA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqi KLLA0E03807P

(Kluyveromyces
lactis) 		PF16787
(NDC10_II) 		3 VAL A  96
GLN A  89
CYH A  68
 None
 0.86A 5icxC-3sqiA:
undetectable
5icxF-3sqiA:
undetectable		 5icxC-3sqiA:
17.66
5icxF-3sqiA:
2.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stb MP18 RNA EDITING
COMPLEX PROTEIN

(Trypanosoma
brucei) 		PF00436
(SSB) 		3 VAL D  95
GLN D  46
CYH D  74
 None
 0.72A 5icxC-3stbD:
undetectable
5icxF-3stbD:
undetectable		 5icxC-3stbD:
20.00
5icxF-3stbD:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t79 KLLA0E03807P

(Kluyveromyces
lactis) 		PF16787
(NDC10_II) 		3 VAL A  96
GLN A  89
CYH A  68
 None
 0.85A 5icxC-3t79A:
undetectable
5icxF-3t79A:
undetectable		 5icxC-3t79A:
19.49
5icxF-3t79A:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt9 PLAKOPHILIN-2

(Homo sapiens) 		PF00514
(Arm) 		3 VAL A 391
GLN A 378
CYH A 381
 None
 0.80A 5icxC-3tt9A:
undetectable
5icxF-3tt9A:
undetectable		 5icxC-3tt9A:
19.76
5icxF-3tt9A:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zkb DNA GYRASE SUBUNIT B

(Mycobacterium
tuberculosis) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		3 VAL A 287
GLN A 385
CYH A 388
 None
 0.91A 5icxC-3zkbA:
undetectable
5icxF-3zkbA:
undetectable		 5icxC-3zkbA:
19.21
5icxF-3zkbA:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ast ALDO-KETO REDUCTASE
AKR14A1

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		3 VAL A 203
GLN A 193
CYH A 219
 None
 0.92A 5icxC-4astA:
undetectable
5icxF-4astA:
undetectable		 5icxC-4astA:
21.52
5icxF-4astA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avx HEPATOCYTE GROWTH
FACTOR-REGULATED
TYROSINE KINASE
SUBSTRATE

(Homo sapiens) 		PF00790
(VHS)
PF01363
(FYVE) 		3 VAL A  67
GLN A  30
CYH A  32
 None
 0.64A 5icxC-4avxA:
undetectable
5icxF-4avxA:
undetectable		 5icxC-4avxA:
22.73
5icxF-4avxA:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9w TUDOR
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00567
(TUDOR) 		3 VAL A 789
GLN A 806
CYH A 763
 None
 0.82A 5icxC-4b9wA:
undetectable
5icxF-4b9wA:
undetectable		 5icxC-4b9wA:
20.88
5icxF-4b9wA:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 VAL A   7
GLN A 104
CYH A 107
 None
 0.80A 5icxC-4c2kA:
undetectable
5icxF-4c2kA:
undetectable		 5icxC-4c2kA:
18.57
5icxF-4c2kA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 VAL A 912
GLN A 942
CYH A 945
 None
 0.63A 5icxC-4c3hA:
3.7
5icxF-4c3hA:
undetectable		 5icxC-4c3hA:
8.53
5icxF-4c3hA:
1.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3z MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF00005
(ABC_tran) 		3 VAL A 782
GLN A 742
CYH A 744
 None
 0.90A 5icxC-4c3zA:
undetectable
5icxF-4c3zA:
undetectable		 5icxC-4c3zA:
20.59
5icxF-4c3zA:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dni FUSION PROTEIN OF
RNA-EDITING COMPLEX
PROTEINS MP42 AND
MP18

(Trypanosoma
brucei) 		PF00436
(SSB) 		3 VAL A 233
GLN A 184
CYH A 212
 None
 0.74A 5icxC-4dniA:
undetectable
5icxF-4dniA:
undetectable		 5icxC-4dniA:
20.00
5icxF-4dniA:
6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 VAL A 764
GLN A 721
CYH A 724
 None
 0.85A 5icxC-4fxdA:
undetectable
5icxF-4fxdA:
undetectable		 5icxC-4fxdA:
14.05
5icxF-4fxdA:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1t INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 2

(Homo sapiens) 		PF13181
(TPR_8) 		3 VAL A 336
GLN A 286
CYH A 289
 None
 0.73A 5icxC-4g1tA:
undetectable
5icxF-4g1tA:
undetectable		 5icxC-4g1tA:
17.72
5icxF-4g1tA:
3.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE

(Escherichia
coli) 		PF13649
(Methyltransf_25) 		3 VAL A  54
GLN A  59
CYH A  83
 None
 0.83A 5icxC-4gekA:
undetectable
5icxF-4gekA:
undetectable		 5icxC-4gekA:
20.60
5icxF-4gekA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imi SYMPLEKIN

(Drosophila
melanogaster) 		PF11935
(DUF3453) 		3 VAL A 104
GLN A  92
CYH A  94
 None
 0.83A 5icxC-4imiA:
undetectable
5icxF-4imiA:
undetectable		 5icxC-4imiA:
22.45
5icxF-4imiA:
3.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwn TRNA
(CMO5U34)-METHYLTRAN
SFERASE

(Escherichia
coli) 		PF13649
(Methyltransf_25) 		3 VAL A  54
GLN A  59
CYH A  83
 None
 0.85A 5icxC-4iwnA:
undetectable
5icxF-4iwnA:
undetectable		 5icxC-4iwnA:
21.31
5icxF-4iwnA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j25 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
putida) 		PF13640
(2OG-FeII_Oxy_3) 		3 VAL A 166
GLN A  25
CYH A 172
 None
 0.84A 5icxC-4j25A:
undetectable
5icxF-4j25A:
undetectable		 5icxC-4j25A:
19.83
5icxF-4j25A:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpu ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans) 		PF01012
(ETF) 		3 VAL B   5
GLN B  39
CYH B  73
 None
 0.69A 5icxC-4kpuB:
undetectable
5icxF-4kpuB:
undetectable		 5icxC-4kpuB:
22.69
5icxF-4kpuB:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1k D-ALANINE--D-ALANINE
LIGASE

(Xanthomonas
oryzae) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 VAL A 316
GLN A 291
CYH A 295
 None
 0.65A 5icxC-4l1kA:
2.1
5icxF-4l1kA:
undetectable		 5icxC-4l1kA:
19.79
5icxF-4l1kA:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		3 VAL A 209
GLN A 282
CYH A 284
 None
 0.82A 5icxC-4m69A:
undetectable
5icxF-4m69A:
undetectable		 5icxC-4m69A:
20.00
5icxF-4m69A:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis) 		PF02222
(ATP-grasp) 		3 VAL A 235
GLN A 228
CYH A 188
 None
 0.82A 5icxC-4ma5A:
undetectable
5icxF-4ma5A:
undetectable		 5icxC-4ma5A:
20.98
5icxF-4ma5A:
3.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0r PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
vulgatus) 		PF13204
(DUF4038)
PF16586
(DUF5060) 		3 VAL A 333
GLN A 328
CYH A 352
 None
NI  A 602 (-2.7A)
None
 0.72A 5icxC-4n0rA:
4.1
5icxF-4n0rA:
undetectable		 5icxC-4n0rA:
19.20
5icxF-4n0rA:
2.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nlh TAX1-BINDING PROTEIN
1

(Homo sapiens) 		PF07888
(CALCOCO1) 		3 VAL A  50
GLN A  20
CYH A  34
 None
 0.85A 5icxC-4nlhA:
3.6
5icxF-4nlhA:
undetectable		 5icxC-4nlhA:
20.83
5icxF-4nlhA:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opw UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		PF10988
(DUF2807) 		3 VAL A 155
GLN A 141
CYH A 138
 None
 0.83A 5icxC-4opwA:
undetectable
5icxF-4opwA:
undetectable		 5icxC-4opwA:
20.16
5icxF-4opwA:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4owr MRNA EXPORT FACTOR

(Homo sapiens) 		PF00400
(WD40) 		3 VAL A 101
GLN A  82
CYH A  68
 None
 0.82A 5icxC-4owrA:
undetectable
5icxF-4owrA:
undetectable		 5icxC-4owrA:
23.58
5icxF-4owrA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p08 COCAINE ESTERASE

(Rhodococcus sp.
MB1) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		3 VAL A 111
GLN A 104
CYH A 107
 None
 0.91A 5icxC-4p08A:
undetectable
5icxF-4p08A:
undetectable		 5icxC-4p08A:
17.38
5icxF-4p08A:
2.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		3 VAL A1047
GLN A1072
CYH A1074
 None
 0.89A 5icxC-5a31A:
undetectable
5icxF-5a31A:
undetectable		 5icxC-5a31A:
9.48
5icxF-5a31A:
1.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djq CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT
CCOP1

(Pseudomonas
stutzeri) 		PF13442
(Cytochrome_CBB3)
PF14715
(FixP_N) 		3 VAL C 201
GLN C 231
CYH C 233
 HEC  C 401 ( 4.5A)
None
HEC  C 401 (-1.7A)
 0.84A 5icxC-5djqC:
undetectable
5icxF-5djqC:
undetectable		 5icxC-5djqC:
18.44
5icxF-5djqC:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8c UL34 PROTEIN

(Suid
alphaherpesvirus
1) 		PF04541
(Herpes_U34) 		3 VAL B   6
GLN B  39
CYH B  20
 None
 0.83A 5icxC-5e8cB:
undetectable
5icxF-5e8cB:
undetectable		 5icxC-5e8cB:
21.46
5icxF-5e8cB:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guj DNA PRIMASE

(Bacillus
subtilis) 		PF08275
(Toprim_N)
PF10410
(DnaB_bind)
PF13155
(Toprim_2) 		3 VAL A 297
GLN A 329
CYH A 333
 None
 0.65A 5icxC-5gujA:
undetectable
5icxF-5gujA:
undetectable		 5icxC-5gujA:
22.62
5icxF-5gujA:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huc 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE (DAHP)
SYNTHASE

(Corynebacterium
glutamicum) 		PF01474
(DAHP_synth_2) 		3 VAL A  69
GLN A 288
CYH A 255
 None
 0.88A 5icxC-5hucA:
undetectable
5icxF-5hucA:
undetectable		 5icxC-5hucA:
17.90
5icxF-5hucA:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		3 VAL A 109
GLN A 137
CYH A 133
 None
IDV  A 401 (-3.7A)
IDV  A 401 (-4.6A)
 0.81A 5icxC-5i3oA:
2.5
5icxF-5i3oA:
undetectable		 5icxC-5i3oA:
19.80
5icxF-5i3oA:
3.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikj CRYPTIC LOCI
REGULATOR 2

(Schizosaccharomyces
pombe) 		PF10383
(Clr2)
PF16761
(Clr2_transil) 		3 VAL A 172
GLN A  46
CYH A  48
 None
 0.92A 5icxC-5ikjA:
undetectable
5icxF-5ikjA:
undetectable		 5icxC-5ikjA:
19.43
5icxF-5ikjA:
2.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0w CLASS B
CARBAPENEMASE GOB-18

(Elizabethkingia
meningoseptica) 		PF00753
(Lactamase_B) 		3 VAL A 120
GLN A  98
CYH A 180
 None
ZN  A 302 ( 2.6A)
None
 0.63A 5icxC-5k0wA:
undetectable
5icxF-5k0wA:
undetectable		 5icxC-5k0wA:
19.39
5icxF-5k0wA:
4.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksd ATPASE 2, PLASMA
MEMBRANE-TYPE

(Arabidopsis
thaliana) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		3 VAL A 210
GLN A  25
CYH A  28
 None
 0.82A 5icxC-5ksdA:
undetectable
5icxF-5ksdA:
undetectable		 5icxC-5ksdA:
13.52
5icxF-5ksdA:
1.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ku1 MITOCHONDRIAL RHO
GTPASE 1

(Homo sapiens) 		PF08355
(EF_assoc_1)
PF08356
(EF_assoc_2) 		3 VAL A 434
GLN A 555
CYH A 493
 None
 0.92A 5icxC-5ku1A:
undetectable
5icxF-5ku1A:
undetectable		 5icxC-5ku1A:
17.17
5icxF-5ku1A:
3.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m9n TUDOR
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00567
(TUDOR) 		3 VAL A 649
GLN A 512
CYH A 510
 None
 0.83A 5icxC-5m9nA:
undetectable
5icxF-5m9nA:
undetectable		 5icxC-5m9nA:
23.05
5icxF-5m9nA:
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nth PUTATIVE
AMINOPEPTIDASE

(Leishmania
major) 		PF00883
(Peptidase_M17) 		3 VAL A 529
GLN A 215
CYH A 217
 None
 0.90A 5icxC-5nthA:
undetectable
5icxF-5nthA:
undetectable		 5icxC-5nthA:
17.16
5icxF-5nthA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uag DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA

(Escherichia
coli) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		3 VAL A  92
GLN A 147
CYH A  54
 None
 0.88A 5icxC-5uagA:
3.5
5icxF-5uagA:
undetectable		 5icxC-5uagA:
20.51
5icxF-5uagA:
4.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqi PHOSPHOSUGAR
ISOMERASE

(Escherichia
coli) 		no annotation 3 VAL A  46
GLN A  40
CYH A  42
 None
 0.91A 5icxC-5uqiA:
undetectable
5icxF-5uqiA:
undetectable		 5icxC-5uqiA:
16.20
5icxF-5uqiA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vh2 CADHERIN-23

(Mus musculus) 		no annotation 3 VAL A1208
GLN A1189
CYH A1274
 None
 0.84A 5icxC-5vh2A:
4.9
5icxF-5vh2A:
undetectable		 5icxC-5vh2A:
18.40
5icxF-5vh2A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkq NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L

(Drosophila
melanogaster) 		PF00023
(Ank)
PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4) 		3 VAL A 842
GLN A 802
CYH A 830
 None
 0.82A 5icxC-5vkqA:
undetectable
5icxF-5vkqA:
undetectable		 5icxC-5vkqA:
8.76
5icxF-5vkqA:
0.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1

(Arabidopsis
thaliana) 		no annotation 3 VAL A 542
GLN A 582
CYH A 585
 None
 0.71A 5icxC-5wblA:
undetectable
5icxF-5wblA:
undetectable		 5icxC-5wblA:
17.37
5icxF-5wblA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
ES27

(Toxoplasma
gondii) 		PF01015
(Ribosomal_S3Ae) 		3 VAL b  44
GLN b  63
CYH b  69
 None
 0.87A 5icxC-5xxub:
undetectable
5icxF-5xxub:
undetectable		 5icxC-5xxub:
17.44
5icxF-5xxub:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi GUANINE
NUCLEOTIDE-BINDING
PROTEIN BETA
SUBUNIT, PUTATIVE

(Trichomonas
vaginalis) 		no annotation 3 VAL g 184
GLN g 145
CYH g 161
 None
 0.84A 5icxC-5xyig:
undetectable
5icxF-5xyig:
undetectable		 5icxC-5xyig:
19.94
5icxF-5xyig:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzx IMPORTIN SUBUNIT
ALPHA-3

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		3 VAL A  92
GLN A 132
CYH A 122
 None
 0.82A 5icxC-5xzxA:
undetectable
5icxF-5xzxA:
undetectable		 5icxC-5xzxA:
18.95
5icxF-5xzxA:
2.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y00 GREEN FLUORESCENT
PROTEIN

(Olindias) 		no annotation 3 VAL A 186
GLN A  88
CYH A  90
 None
 0.92A 5icxC-5y00A:
undetectable
5icxF-5y00A:
undetectable		 5icxC-5y00A:
16.59
5icxF-5y00A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yt6 TAX1-BINDING PROTEIN
1

(Homo sapiens) 		no annotation 3 VAL F  57
GLN F  43
CYH F  40
 None
None
ZN  F 101 (-2.3A)
 0.84A 5icxC-5yt6F:
undetectable
5icxF-5yt6F:
undetectable		 5icxC-5yt6F:
8.70
5icxF-5yt6F:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3

(Saccharomyces
cerevisiae) 		no annotation 3 VAL O 274
GLN O 193
CYH O 195
 None
 0.89A 5icxC-6eu2O:
undetectable
5icxF-6eu2O:
undetectable		 5icxC-6eu2O:
19.90
5icxF-6eu2O:
7.50