SIMILAR PATTERNS OF AMINO ACIDS FOR 5IAO_C_URFC301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i51 CASPASE-7 SUBUNIT
P20

(Homo sapiens) 		PF00656
(Peptidase_C14) 		3 ARG A 167
HIS A 165
ARG A 170
 None
 1.01A 5iaoC-1i51A:
undetectable		 5iaoC-1i51A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4l 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Magnaporthe
grisea) 		PF00926
(DHBP_synthase) 		3 ARG A 150
HIS A 153
ARG A  36
 SO4  A1001 (-2.9A)
MN  A1003 ( 3.4A)
SO4  A1001 (-2.9A)
 1.09A 5iaoC-1k4lA:
0.0		 5iaoC-1k4lA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU

(Haemophilus
influenzae) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		3 ARG A  45
HIS A  46
ARG A  37
 None
 1.15A 5iaoC-1kyiA:
0.4		 5iaoC-1kyiA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o94 TRIMETHYLAMINE
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		3 ARG A 343
HIS A 689
ARG A 406
 None
 1.03A 5iaoC-1o94A:
undetectable		 5iaoC-1o94A:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o94 TRIMETHYLAMINE
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		3 ARG A 447
HIS A 689
ARG A 406
 None
 0.90A 5iaoC-1o94A:
undetectable		 5iaoC-1o94A:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		3 ARG A 339
HIS A 285
ARG A 284
 None
 0.84A 5iaoC-1odoA:
undetectable		 5iaoC-1odoA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)

(Synechococcus
elongatus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 ARG A  41
HIS A 310
ARG A 134
 None
 1.06A 5iaoC-1rblA:
undetectable		 5iaoC-1rblA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1siq GLUTARYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 ARG A  28
HIS A 266
ARG A  88
 None
 1.06A 5iaoC-1siqA:
undetectable		 5iaoC-1siqA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snn 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Methanocaldococcus
jannaschii) 		PF00926
(DHBP_synthase) 		3 ARG A 161
HIS A 164
ARG A  25
 5RP  A 401 (-3.1A)
ZN  A 402 ( 3.2A)
5RP  A 401 (-2.9A)
 1.10A 5iaoC-1snnA:
undetectable		 5iaoC-1snnA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tc3 PROTEIN (TC3
TRANSPOSASE)

(Caenorhabditis
elegans) 		PF11427
(HTH_Tnp_Tc3_1) 		3 ARG C 236
HIS C 237
ARG C 240
 None
 1.06A 5iaoC-1tc3C:
undetectable		 5iaoC-1tc3C:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ARP2/3 COMPLEX 20KDA
SUBUNIT
ARP2/3 COMPLEX 34KDA
SUBUNIT

(Bos taurus) 		PF04045
(P34-Arc)
PF05856
(ARPC4) 		3 ARG F  97
HIS D 263
ARG D 267
 None
 0.97A 5iaoC-1u2vF:
undetectable		 5iaoC-1u2vF:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u78 TRANSPOSABLE ELEMENT
TC3 TRANSPOSASE

(Caenorhabditis
elegans) 		PF01498
(HTH_Tnp_Tc3_2)
PF11427
(HTH_Tnp_Tc3_1) 		3 ARG A  36
HIS A  37
ARG A  40
 None
 1.02A 5iaoC-1u78A:
undetectable		 5iaoC-1u78A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		3 ARG A 316
HIS A 318
ARG A 354
 None
 1.01A 5iaoC-1x8vA:
undetectable		 5iaoC-1x8vA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yll CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF05962
(HutD) 		3 ARG A  72
HIS A  98
ARG A  74
 None
 0.98A 5iaoC-1yllA:
undetectable		 5iaoC-1yllA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlp PETAL DEATH PROTEIN

(Dianthus
caryophyllus) 		PF13714
(PEP_mutase) 		3 ARG A 193
HIS A 186
ARG A 194
 None
 0.76A 5iaoC-1zlpA:
undetectable		 5iaoC-1zlpA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy1 PEPTIDE DEFORMYLASE,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF01327
(Pep_deformylase) 		3 ARG A 149
HIS A 153
ARG A 123
 None
ZN  A 198 (-3.3A)
None
 1.17A 5iaoC-1zy1A:
undetectable		 5iaoC-1zy1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		3 ARG A 380
HIS A 786
ARG A 386
 PO4  A 842 (-2.8A)
PO4  A 842 ( 4.7A)
PO4  A 842 (-3.1A)
 0.98A 5iaoC-2a3lA:
undetectable		 5iaoC-2a3lA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9u HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Sulfurisphaera
tokodaii) 		PF00908
(dTDP_sugar_isom) 		3 ARG A 143
HIS A 141
ARG A  64
 None
 1.06A 5iaoC-2b9uA:
undetectable		 5iaoC-2b9uA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Homo sapiens) 		PF00698
(Acyl_transf_1) 		3 ARG A 269
HIS A 268
ARG A 271
 SO4  A1340 (-3.8A)
SO4  A1340 (-4.0A)
SO4  A1340 (-2.8A)
 0.90A 5iaoC-2c2nA:
undetectable		 5iaoC-2c2nA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db3 ATP-DEPENDENT RNA
HELICASE VASA

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 ARG A 582
HIS A 575
ARG A 579
 ANP  A2901 (-3.2A)
None
ANP  A2901 (-2.6A)
 1.14A 5iaoC-2db3A:
3.2		 5iaoC-2db3A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epg HYPOTHETICAL PROTEIN
TTHA1785

(Thermus
thermophilus) 		PF01139
(RtcB) 		3 ARG A 187
HIS A 243
ARG A 191
 None
 0.82A 5iaoC-2epgA:
undetectable		 5iaoC-2epgA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES

(Escherichia
coli) 		PF07995
(GSDH) 		3 ARG A 323
HIS A  16
ARG A  34
 EDO  A3006 (-4.2A)
EDO  A3025 (-3.8A)
EDO  A3025 (-4.0A)
 0.74A 5iaoC-2g8sA:
undetectable		 5iaoC-2g8sA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2or2 1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE

(Bacillus
thuringiensis) 		PF00388
(PI-PLC-X) 		3 ARG A 163
HIS A  32
ARG A  69
 None
 0.75A 5iaoC-2or2A:
undetectable		 5iaoC-2or2A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plc PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C

(Listeria
monocytogenes) 		PF00388
(PI-PLC-X) 		3 ARG A 124
HIS A  45
ARG A  84
 None
 0.94A 5iaoC-2plcA:
undetectable		 5iaoC-2plcA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvq RIBOSE-5-PHOSPHATE
ISOMERASE B

(Mycobacterium
tuberculosis) 		PF02502
(LacAB_rpiB) 		3 ARG A 140
HIS A 138
ARG A 141
 None
 0.93A 5iaoC-2vvqA:
2.6		 5iaoC-2vvqA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x49 INVASION PROTEIN
INVA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		3 ARG A 431
HIS A 483
ARG A 475
 None
 0.84A 5iaoC-2x49A:
undetectable		 5iaoC-2x49A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK

([Ruminococcus]
gnavus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		3 ARG A 674
HIS A 698
ARG A 672
 None
 0.70A 5iaoC-2yfnA:
undetectable		 5iaoC-2yfnA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3t CYTOCHROME P450

(Streptomyces
sp. TP-A0274) 		PF00067
(p450) 		3 ARG A 306
HIS A 106
ARG A  67
 HEM  A 500 (-2.7A)
HEM  A 500 (-3.8A)
HEM  A 500 (-2.3A)
 1.03A 5iaoC-2z3tA:
undetectable		 5iaoC-2z3tA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI

(Streptococcus
mutans) 		PF02324
(Glyco_hydro_70) 		3 ARG A 656
HIS A 587
ARG A 475
 None
 1.16A 5iaoC-3aibA:
undetectable		 5iaoC-3aibA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmg PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 ARG A 590
HIS A 340
ARG A 324
 None
 1.14A 5iaoC-3cmgA:
undetectable		 5iaoC-3cmgA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm8 UNCHARACTERIZED
PROTEIN RPA4348

(Rhodopseudomonas
palustris) 		PF12680
(SnoaL_2) 		3 ARG A 104
HIS A  73
ARG A  89
 None
 0.95A 5iaoC-3dm8A:
undetectable		 5iaoC-3dm8A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dui BETA-GALACTOSIDE-BIN
DING LECTIN

(Gallus gallus) 		PF00337
(Gal-bind_lectin) 		3 ARG A  74
HIS A  53
ARG A  49
 None
 1.15A 5iaoC-3duiA:
undetectable		 5iaoC-3duiA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3k UNCHARACTERIZED
PROTEIN YKR043C

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		3 ARG A  12
HIS A 178
ARG A 181
 None
 0.77A 5iaoC-3f3kA:
1.7		 5iaoC-3f3kA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 ARG A 432
HIS A 425
ARG A 429
 ANP  A 480 (-2.8A)
None
ANP  A 480 (-2.8A)
 1.03A 5iaoC-3fhtA:
3.7		 5iaoC-3fhtA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ARG A 497
HIS A 490
ARG A 481
 None
 1.12A 5iaoC-3ihvA:
undetectable		 5iaoC-3ihvA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus) 		no annotation 3 ARG A 594
HIS A 652
ARG A 760
 None
 0.99A 5iaoC-3j3iA:
undetectable		 5iaoC-3j3iA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8c RIBOSE 5-PHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF02502
(LacAB_rpiB) 		3 ARG A 140
HIS A 138
ARG A 141
 None
 0.94A 5iaoC-3k8cA:
undetectable		 5iaoC-3k8cA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksy SON OF SEVENLESS
HOMOLOG 1

(Homo sapiens) 		PF00125
(Histone)
PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		3 ARG A 706
HIS A 700
ARG A 632
 None
 0.94A 5iaoC-3ksyA:
undetectable		 5iaoC-3ksyA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE

(Exiguobacterium
sibiricum) 		PF01212
(Beta_elim_lyase) 		3 ARG A 177
HIS A  97
ARG A 145
 LLP  A 205 ( 2.9A)
LLP  A 205 ( 3.3A)
LLP  A 205 ( 4.4A)
 1.12A 5iaoC-3lwsA:
2.7		 5iaoC-3lwsA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1p RIBOSE 5-PHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF02502
(LacAB_rpiB) 		3 ARG A 140
HIS A 138
ARG A 141
 None
None
PO4  A 154 (-3.2A)
 0.93A 5iaoC-3m1pA:
undetectable		 5iaoC-3m1pA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myv SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ARG A 429
HIS A 422
ARG A 413
 None
EDO  A 516 ( 4.3A)
None
 1.15A 5iaoC-3myvA:
undetectable		 5iaoC-3myvA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME

(Bos taurus) 		PF00067
(p450) 		3 ARG A 347
HIS A 349
ARG A 385
 None
 1.06A 5iaoC-3mzsA:
undetectable		 5iaoC-3mzsA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odo RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1

(Homo sapiens) 		PF00621
(RhoGEF) 		3 ARG A 621
HIS A 667
ARG A 680
 None
 1.08A 5iaoC-3odoA:
undetectable		 5iaoC-3odoA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 ARG A 390
HIS A 232
ARG A 287
 FAD  A 601 ( 3.2A)
3NP  A 602 (-4.7A)
3NP  A 602 (-1.4A)
 1.10A 5iaoC-3p4sA:
undetectable		 5iaoC-3p4sA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q75 FARNESYLTRANSFERASE
BETA SUBUNIT

(Cryptococcus
neoformans) 		PF00432
(Prenyltrans) 		3 ARG B 342
HIS B 427
ARG B 343
 None
 0.98A 5iaoC-3q75B:
undetectable		 5iaoC-3q75B:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qmw THIOESTERASE

(Streptomyces
coelicolor) 		PF00975
(Thioesterase) 		3 ARG A 122
HIS A 196
ARG A 198
 None
 0.96A 5iaoC-3qmwA:
undetectable		 5iaoC-3qmwA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqc DNA-DIRECTED RNA
POLYMERASE SUBUNIT
B, DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A', DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''

(Pyrococcus
furiosus) 		PF04560
(RNA_pol_Rpb2_7)
PF04997
(RNA_pol_Rpb1_1) 		3 ARG A 162
HIS A 240
ARG A 230
 None
 0.94A 5iaoC-3qqcA:
undetectable		 5iaoC-3qqcA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 ARG A 469
HIS A 462
ARG A 466
 ANP  A 800 (-2.7A)
None
ANP  A 800 (-2.5A)
 1.12A 5iaoC-3sqwA:
2.7		 5iaoC-3sqwA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc3 UV DAMAGE
ENDONUCLEASE

(Sulfolobus
acidocaldarius) 		PF03851
(UvdE) 		3 ARG A   2
HIS A   0
ARG A 226
 None
 0.99A 5iaoC-3tc3A:
undetectable		 5iaoC-3tc3A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Enterobacter
sp. 638) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ARG A  15
HIS A  19
ARG A 382
 None
 0.88A 5iaoC-3tjiA:
undetectable		 5iaoC-3tjiA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl2 MALATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 ARG A  93
HIS A 180
ARG A  87
 None
 1.16A 5iaoC-3tl2A:
1.7		 5iaoC-3tl2A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzi CRISPR-ASSOCIATED
PROTEIN CAS5, DVULG
SUBTYPE

(Xanthomonas
oryzae) 		PF09704
(Cas_Cas5d) 		3 ARG A 141
HIS A  44
ARG A 142
 None
 0.90A 5iaoC-3vziA:
undetectable		 5iaoC-3vziA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus) 		PF00141
(peroxidase) 		3 ARG A 471
HIS A 619
ARG A 576
 None
 0.93A 5iaoC-3wxoA:
undetectable		 5iaoC-3wxoA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aui PORIN (PORB)

(Neisseria
gonorrhoeae) 		PF00267
(Porin_1) 		3 ARG A 124
HIS A 125
ARG A  92
 ATP  A 400 ( 3.0A)
None
PO4  A 402 (-4.3A)
 1.09A 5iaoC-4auiA:
undetectable		 5iaoC-4auiA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli) 		PF01728
(FtsJ) 		3 ARG A   9
HIS A 343
ARG A 345
 None
 0.70A 5iaoC-4aukA:
2.3		 5iaoC-4aukA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0t PUP--PROTEIN LIGASE

(Corynebacterium
glutamicum) 		PF03136
(Pup_ligase) 		3 ARG A 422
HIS A 211
ARG A 418
 None
ADP  A1478 (-3.0A)
ADP  A1478 (-3.4A)
 1.16A 5iaoC-4b0tA:
undetectable		 5iaoC-4b0tA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		3 ARG A 426
HIS A 379
ARG A 493
 None
GOL  A1562 (-4.2A)
None
 1.15A 5iaoC-4cmnA:
undetectable		 5iaoC-4cmnA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d25 BMVLG PROTEIN

(Bombyx mori) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 ARG A 524
HIS A 517
ARG A 521
 ANP  A1564 (-2.9A)
None
ANP  A1564 (-2.5A)
 1.10A 5iaoC-4d25A:
3.2		 5iaoC-4d25A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doh INTERLEUKIN-20

(Homo sapiens) 		PF00726
(IL10) 		3 ARG A 124
HIS A 127
ARG A  84
 None
 1.11A 5iaoC-4dohA:
undetectable		 5iaoC-4dohA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkg C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB

(Sinorhizobium
meliloti) 		no annotation 3 ARG A 355
HIS A 348
ARG A 352
 None
 0.92A 5iaoC-4gkgA:
undetectable		 5iaoC-4gkgA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8i HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF16227
(DUF4886) 		3 ARG A 233
HIS A 226
ARG A 222
 None
 0.97A 5iaoC-4i8iA:
1.4		 5iaoC-4i8iA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jh8 METALLOTHIOL
TRANSFERASE FOSB

(Bacillus cereus) 		PF00903
(Glyoxalase) 		3 ARG A  94
HIS A 117
ARG A  96
 FCN  A 204 ( 3.9A)
None
FCN  A 204 ( 4.4A)
 1.15A 5iaoC-4jh8A:
undetectable		 5iaoC-4jh8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		3 ARG E 315
HIS E 426
ARG E 311
 None
 1.16A 5iaoC-4mh0E:
undetectable		 5iaoC-4mh0E:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5a PROTEIN EFR3

(Saccharomyces
cerevisiae) 		no annotation 3 ARG A  25
HIS A  67
ARG A  69
 None
 0.84A 5iaoC-4n5aA:
undetectable		 5iaoC-4n5aA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		3 ARG A 555
HIS A 558
ARG A 554
 None
 0.90A 5iaoC-4nh0A:
2.2		 5iaoC-4nh0A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8e 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Vibrio cholerae) 		PF00926
(DHBP_synthase) 		3 ARG A 151
HIS A 154
ARG A  38
 5RP  A 301 (-2.8A)
ZN  A 302 ( 3.2A)
5RP  A 301 (-3.3A)
 1.09A 5iaoC-4p8eA:
undetectable		 5iaoC-4p8eA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcb TRWC

(Escherichia
coli) 		PF08751
(TrwC) 		3 ARG A 112
HIS A 202
ARG A 116
 None
 0.96A 5iaoC-4pcbA:
undetectable		 5iaoC-4pcbA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 ARG A 101
HIS A 179
ARG A 169
 None
 1.12A 5iaoC-4qiwA:
undetectable		 5iaoC-4qiwA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qqv INTERLEUKIN-3
RECEPTOR CLASS 2
SUBUNIT BETA

(Mus musculus) 		PF09240
(IL6Ra-bind)
PF09294
(Interfer-bind) 		3 ARG A 195
HIS A 171
ARG A 197
 None
 1.01A 5iaoC-4qqvA:
undetectable		 5iaoC-4qqvA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		3 ARG A1879
HIS A1883
ARG A1937
 None
 1.17A 5iaoC-4r7yA:
undetectable		 5iaoC-4r7yA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv3 1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE

(Staphylococcus
aureus) 		PF00388
(PI-PLC-X) 		3 ARG A 166
HIS A  30
ARG A  67
 INS  A 402 (-2.6A)
INS  A 402 (-3.6A)
INS  A 402 (-3.5A)
 0.73A 5iaoC-4rv3A:
undetectable		 5iaoC-4rv3A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 ARG A 469
HIS A 462
ARG A 466
 BEF  A 602 ( 2.6A)
None
BEF  A 602 (-3.0A)
 1.11A 5iaoC-4tz0A:
2.6		 5iaoC-4tz0A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u98 MALTOKINASE

(Mycolicibacterium
vanbaalenii) 		PF01636
(APH) 		3 ARG A  13
HIS A  11
ARG A  12
 None
 0.89A 5iaoC-4u98A:
undetectable		 5iaoC-4u98A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN

(Agrobacterium
tumefaciens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 ARG A 445
HIS A 350
ARG A  56
 None
 1.16A 5iaoC-4uphA:
undetectable		 5iaoC-4uphA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wab PROSTAGLANDIN E
SYNTHASE,LEUKOTRIENE
C4 SYNTHASE

(Homo sapiens) 		PF01124
(MAPEG) 		3 ARG A 150
HIS A 151
ARG A 158
 None
 1.07A 5iaoC-4wabA:
undetectable		 5iaoC-4wabA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A

(Thermotoga
maritima) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		3 ARG B 300
HIS B 326
ARG B 296
 None
 1.04A 5iaoC-4yryB:
undetectable		 5iaoC-4yryB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amo NOELIN

(Mus musculus) 		PF02191
(OLF) 		3 ARG A 293
HIS A 296
ARG A 272
 None
 0.93A 5iaoC-5amoA:
undetectable		 5iaoC-5amoA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3

(Homo sapiens) 		PF00035
(dsrm)
PF00636
(Ribonuclease_3)
PF14622
(Ribonucleas_3_3) 		3 ARG A 622
HIS A 903
ARG A 914
 None
 0.99A 5iaoC-5b16A:
undetectable		 5iaoC-5b16A:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn7 MALTODEXTRIN
GLUCOSIDASE

(Escherichia
coli) 		PF00128
(Alpha-amylase) 		3 ARG A 132
HIS A 209
ARG A 496
 None
 1.07A 5iaoC-5bn7A:
undetectable		 5iaoC-5bn7A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Pseudothermotoga
lettingae) 		PF13416
(SBP_bac_8) 		3 ARG A 367
HIS A 188
ARG A 136
 T6T  A 501 (-3.0A)
None
T6T  A 501 (-3.0A)
 0.87A 5iaoC-5ci5A:
undetectable		 5iaoC-5ci5A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ARG A 156
HIS A 569
ARG A 225
 None
 1.12A 5iaoC-5ck0A:
undetectable		 5iaoC-5ck0A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d4w PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		3 ARG A 423
HIS A 379
ARG A 420
 None
 1.14A 5iaoC-5d4wA:
undetectable		 5iaoC-5d4wA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dcz TANKYRASE-2

(Homo sapiens) 		PF00644
(PARP) 		3 ARG A1143
HIS A1123
ARG A1012
 None
 1.15A 5iaoC-5dczA:
undetectable		 5iaoC-5dczA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dnw SHKAI2IB

(Striga
hermonthica) 		PF12697
(Abhydrolase_6) 		3 ARG A   8
HIS A  75
ARG A  66
 None
 1.02A 5iaoC-5dnwA:
undetectable		 5iaoC-5dnwA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elx ATP-DEPENDENT RNA
HELICASE DBP5

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 ARG A 429
HIS A 422
ARG A 426
 BEF  A 503 ( 2.6A)
None
BEF  A 503 (-2.7A)
 1.12A 5iaoC-5elxA:
3.4		 5iaoC-5elxA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grm STIMULATOR OF
INTERFERON GENES
PROTEIN

(Rattus
norvegicus) 		no annotation 3 ARG A 310
HIS A 308
ARG A 197
 None
 1.12A 5iaoC-5grmA:
undetectable		 5iaoC-5grmA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h71 ALGQ2

(Sphingomonas
sp.) 		PF01547
(SBP_bac_1) 		3 ARG A 193
HIS A 187
ARG A 137
 None
BEM  A 503 ( 3.9A)
BEM  A 502 ( 3.7A)
 1.06A 5iaoC-5h71A:
undetectable		 5iaoC-5h71A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hh9 PVDN

(Pseudomonas
aeruginosa) 		PF00266
(Aminotran_5) 		3 ARG A 403
HIS A 148
ARG A 396
 None
PLP  A 501 (-3.5A)
PLP  A 501 ( 4.6A)
 1.05A 5iaoC-5hh9A:
4.0		 5iaoC-5hh9A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxi NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4

(Homo sapiens) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		3 ARG A  39
HIS A  68
ARG A 122
 None
 1.02A 5iaoC-5kxiA:
undetectable		 5iaoC-5kxiA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8v DNA REPAIR AND
RECOMBINATION
PROTEIN RADA

(Pyrococcus
furiosus) 		PF08423
(Rad51) 		3 ARG A 257
HIS A 303
ARG A 245
 None
 1.17A 5iaoC-5l8vA:
undetectable		 5iaoC-5l8vA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2

(Saccharomyces
cerevisiae) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		3 ARG A 140
HIS A  73
ARG A  80
 None
 1.06A 5iaoC-5lkdA:
undetectable		 5iaoC-5lkdA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njo PUTATIVE CUPIN_2
DOMAIN-CONTAINING
ISOMERASE

(Streptomyces
coeruleorubidus) 		no annotation 3 ARG A  86
HIS A  88
ARG A 112
 None
 1.07A 5iaoC-5njoA:
undetectable		 5iaoC-5njoA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oec GTGE

(Salmonella
enterica) 		no annotation 3 ARG A  56
HIS A  26
ARG A  28
 None
 1.17A 5iaoC-5oecA:
undetectable		 5iaoC-5oecA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opz CHIX

(Serratia
marcescens) 		no annotation 3 ARG A  52
HIS A  69
ARG A  48
 None
ZN  A 201 (-3.3A)
ZN  A 201 ( 4.5A)
 1.16A 5iaoC-5opzA:
undetectable		 5iaoC-5opzA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xev XAA-PRO
DIPEPTIDASE,PEPTIDAS
E-RELATED PROTEIN

(Deinococcus
radiodurans) 		no annotation 3 ARG A  47
HIS A  87
ARG A 126
 None
 0.94A 5iaoC-5xevA:
undetectable		 5iaoC-5xevA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6r GENOME POLYPROTEIN

(Pestivirus C) 		no annotation 3 ARG A 111
HIS A 166
ARG A 170
 SO4  A 702 ( 3.6A)
SO4  A 702 (-4.3A)
SO4  A 702 (-3.6A)
 0.89A 5iaoC-5y6rA:
undetectable		 5iaoC-5y6rA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yeu -

(-) 		no annotation 3 ARG A 161
HIS A 158
ARG A 162
 None
 0.94A 5iaoC-5yeuA:
undetectable		 5iaoC-5yeuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dzs HOMOSERINE
DEHYDROGENASE

(Mycolicibacterium
hassiacum) 		no annotation 3 ARG A 336
HIS A 125
ARG A 333
 None
 1.04A 5iaoC-6dzsA:
2.2		 5iaoC-6dzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eot DIPEPTIDYL PEPTIDASE
8

(Homo sapiens) 		no annotation 3 ARG A  98
HIS A  95
ARG A  88
 None
 1.06A 5iaoC-6eotA:
undetectable		 5iaoC-6eotA:
15.08