SIMILAR PATTERNS OF AMINO ACIDS FOR 5IAO_A_URFA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 ARG A 339
ASP A 336
HIS A 285
ARG A 284
 None
 1.21A 5iaoA-1odoA:
0.0		 5iaoA-1odoA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 ARG A 203
ASP A  19
HIS A  83
ARG A  10
 None
None
PO4  A 911 (-3.6A)
PO4  A 911 (-2.8A)
 1.35A 5iaoA-2hnhA:
0.0		 5iaoA-2hnhA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6f HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DRB1-4 BETA
CHAIN

(Homo sapiens) 		PF00969
(MHC_II_beta)
PF07654
(C1-set) 		4 ARG B  68
ASP B  70
HIS B  45
ARG B  58
 None
 1.47A 5iaoA-3o6fB:
0.0		 5iaoA-3o6fB:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2

(Homo sapiens) 		PF00632
(HECT) 		4 ARG A 841
ASP A 843
HIS A 768
ARG A 767
 None
 1.50A 5iaoA-4y07A:
0.1		 5iaoA-4y07A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y19 HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DRB1-4 BETA
CHAIN

(Homo sapiens) 		PF00969
(MHC_II_beta)
PF07654
(C1-set) 		4 ARG B  39
ASP B  41
HIS B  16
ARG B  29
 None
 1.44A 5iaoA-4y19B:
0.0		 5iaoA-4y19B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 ARG A 203
ASP A  19
HIS A  83
ARG A  10
 None
 1.45A 5iaoA-5fkuA:
0.0		 5iaoA-5fkuA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j55 CAROTENOID OXYGENASE

(Novosphingobium
aromaticivorans) 		PF03055
(RPE65) 		4 ARG A  78
ASP A  22
HIS A  69
ARG A  67
 None
 1.34A 5iaoA-5j55A:
0.0		 5iaoA-5j55A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 4 ARG A 172
ASP A 391
HIS A 334
ARG A 342
 None
 1.36A 5iaoA-6etzA:
0.0		 5iaoA-6etzA:
20.00