SIMILAR PATTERNS OF AMINO ACIDS FOR 5I9Y_A_1N1A1001_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b6r PROTEIN
(N5-CARBOXYAMINOIMID
AZOLE RIBONUCLEOTIDE
SYNTHETASE)


(Escherichia
coli)
PF02222
(ATP-grasp)
3 ILE A 213
ILE A  76
MET A 225
None
0.50A 5i9yA-1b6rA:
undetectable
5i9yA-1b6rA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bx0 PROTEIN
(FERREDOXIN:NADP+
OXIDOREDUCTASE)


(Spinacia
oleracea)
PF00175
(NAD_binding_1)
3 ILE A 166
ILE A 281
MET A 261
None
0.69A 5i9yA-1bx0A:
undetectable
5i9yA-1bx0A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cle CHOLESTEROL ESTERASE

([Candida]
cylindracea)
PF00135
(COesterase)
3 ILE A 466
ILE A 238
MET A 503
None
0.63A 5i9yA-1cleA:
undetectable
5i9yA-1cleA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crl LIPASE

(Diutina rugosa)
PF00135
(COesterase)
3 ILE A 466
ILE A 238
MET A 503
None
0.67A 5i9yA-1crlA:
undetectable
5i9yA-1crlA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE


(Methanopyrus
kandleri)
PF00296
(Bac_luciferase)
3 ILE A 131
ILE A  93
MET A 182
None
0.65A 5i9yA-1ezwA:
undetectable
5i9yA-1ezwA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gm5 RECG

(Thermotoga
maritima)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF17190
(RecG_N)
PF17191
(RecG_wedge)
3 ILE A 649
ILE A 663
MET A 619
None
0.52A 5i9yA-1gm5A:
undetectable
5i9yA-1gm5A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa)
PF00135
(COesterase)
3 ILE A 466
ILE A 238
MET A 503
None
0.67A 5i9yA-1gz7A:
undetectable
5i9yA-1gz7A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR


(Equus caballus)
PF00079
(Serpin)
3 ILE A 333
ILE A 169
MET A 177
None
0.60A 5i9yA-1hleA:
undetectable
5i9yA-1hleA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hv2 ELONGIN C

(Saccharomyces
cerevisiae)
PF03931
(Skp1_POZ)
3 ILE A  44
ILE A  18
MET A  32
None
0.66A 5i9yA-1hv2A:
undetectable
5i9yA-1hv2A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays)
PF00232
(Glyco_hydro_1)
3 ILE A 397
ILE A 440
MET A 388
None
0.68A 5i9yA-1hxjA:
undetectable
5i9yA-1hxjA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji0 ABC TRANSPORTER

(Thermotoga
maritima)
PF00005
(ABC_tran)
3 ILE A 149
ILE A  91
MET A 162
None
0.71A 5i9yA-1ji0A:
undetectable
5i9yA-1ji0A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqg CARBOXYPEPTIDASE A

(Helicoverpa
armigera)
PF00246
(Peptidase_M14)
PF02244
(Propep_M14)
3 ILE A 297
ILE A 202
MET A  64
None
0.66A 5i9yA-1jqgA:
undetectable
5i9yA-1jqgA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p8r ARGINASE 1

(Rattus
norvegicus)
PF00491
(Arginase)
3 ILE A 177
ILE A 174
MET A 212
None
0.64A 5i9yA-1p8rA:
undetectable
5i9yA-1p8rA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl8 HUMAN SORBITOL
DEHYDROGENASE


(Homo sapiens)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
3 ILE A  93
ILE A 154
MET A  38
None
0.70A 5i9yA-1pl8A:
undetectable
5i9yA-1pl8A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE


(Escherichia
coli)
PF04166
(PdxA)
3 ILE A 185
ILE A 226
MET A 238
None
0.67A 5i9yA-1ps6A:
undetectable
5i9yA-1ps6A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb7 TRNA PSEUDOURIDINE
SYNTHASE D


(Escherichia
coli)
PF01142
(TruD)
3 ILE A  44
ILE A  68
MET A  98
None
0.69A 5i9yA-1sb7A:
undetectable
5i9yA-1sb7A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1seh DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE


(Escherichia
coli)
PF00692
(dUTPase)
3 ILE A  99
ILE A  80
MET A  68
None
None
UMP  A 777 (-4.4A)
0.65A 5i9yA-1sehA:
undetectable
5i9yA-1sehA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION


(Saccharomyces
cerevisiae)
PF14519
(Macro_2)
3 ILE A  19
ILE A 185
MET A 217
None
0.71A 5i9yA-1txzA:
undetectable
5i9yA-1txzA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE


(Bacillus
subtilis)
PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C)
3 ILE X  21
ILE X  50
MET X  84
None
0.70A 5i9yA-1u8xX:
undetectable
5i9yA-1u8xX:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc8 LYSINE BIOSYNTHESIS
ENZYME


(Thermus
thermophilus)
PF08443
(RimK)
3 ILE A 271
ILE A   4
MET A 254
None
0.62A 5i9yA-1uc8A:
undetectable
5i9yA-1uc8A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2


(Homo sapiens)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
3 ILE A 390
ILE A 362
MET A  90
None
0.68A 5i9yA-1wl4A:
undetectable
5i9yA-1wl4A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0y FRV OPERON PROTEIN
FRVX


(Pyrococcus
horikoshii)
PF05343
(Peptidase_M42)
3 ILE A  65
ILE A  37
MET A 341
None
0.63A 5i9yA-1y0yA:
undetectable
5i9yA-1y0yA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb2 HYPOTHETICAL PROTEIN
TA0852


(Thermoplasma
acidophilum)
PF08704
(GCD14)
3 ILE A 164
ILE A 167
MET A 104
None
0.67A 5i9yA-1yb2A:
undetectable
5i9yA-1yb2A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt5 INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE


(Thermotoga
maritima)
PF01513
(NAD_kinase)
3 ILE A 224
ILE A 180
MET A 211
None
0.71A 5i9yA-1yt5A:
undetectable
5i9yA-1yt5A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywk 4-DEOXY-L-THREO-5-HE
XOSULOSE-URONATE
KETOL-ISOMERASE 1


(Enterococcus
faecalis)
PF04962
(KduI)
3 ILE A1079
ILE A1142
MET A1177
None
0.65A 5i9yA-1ywkA:
undetectable
5i9yA-1ywkA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbt PEPTIDE CHAIN
RELEASE FACTOR 1


(Streptococcus
mutans)
PF00472
(RF-1)
PF03462
(PCRF)
3 ILE A 274
ILE A 254
MET A 258
None
0.70A 5i9yA-1zbtA:
undetectable
5i9yA-1zbtA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1


(Homo sapiens)
PF00069
(Pkinase)
3 ILE A 126
ILE A 146
MET A  61
None
0.54A 5i9yA-1zltA:
21.0
5i9yA-1zltA:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7d UVRABC SYSTEM
PROTEIN B


(Bacillus
subtilis)
PF00271
(Helicase_C)
PF02151
(UVR)
PF04851
(ResIII)
PF12344
(UvrB)
3 ILE A 431
ILE A 468
MET A 457
None
0.64A 5i9yA-2d7dA:
undetectable
5i9yA-2d7dA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Sulfurisphaera
tokodaii)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
3 ILE A 248
ILE A 166
MET A 156
None
0.66A 5i9yA-2ep5A:
undetectable
5i9yA-2ep5A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
3 ILE A  72
ILE A  91
MET A  96
None
0.53A 5i9yA-2f9gA:
16.9
5i9yA-2f9gA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE


(Dictyostelium
discoideum)
PF01979
(Amidohydro_1)
3 ILE A 134
ILE A 102
MET A 145
KCX  A 158 ( 4.2A)
None
None
0.69A 5i9yA-2ftwA:
undetectable
5i9yA-2ftwA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grk EVM001

(Ectromelia
virus)
PF02250
(Orthopox_35kD)
3 ILE A  28
ILE A 169
MET A  79
None
0.60A 5i9yA-2grkA:
undetectable
5i9yA-2grkA:
20.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2


(Mus musculus)
PF07714
(Pkinase_Tyr)
3 ILE A 691
ILE A 705
MET A 710
None
0.19A 5i9yA-2henA:
37.5
5i9yA-2henA:
67.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iut DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa)
PF01580
(FtsK_SpoIIIE)
3 ILE A 627
ILE A 495
MET A 479
None
0.67A 5i9yA-2iutA:
undetectable
5i9yA-2iutA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfq GLUTAMATE RACEMASE

(Staphylococcus
aureus)
PF01177
(Asp_Glu_race)
3 ILE A 248
ILE A  36
MET A 153
None
0.70A 5i9yA-2jfqA:
undetectable
5i9yA-2jfqA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kok ARSENATE REDUCTASE

(Brucella
abortus)
PF03960
(ArsC)
3 ILE A   9
ILE A  30
MET A  18
None
0.59A 5i9yA-2kokA:
undetectable
5i9yA-2kokA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA


(Thermotoga
maritima)
PF00072
(Response_reg)
PF00977
(His_biosynth)
3 ILE A  33
ILE A  80
MET A  67
None
0.68A 5i9yA-2lleA:
undetectable
5i9yA-2lleA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA


(Thermotoga
maritima)
PF00072
(Response_reg)
PF00977
(His_biosynth)
3 ILE A  41
ILE A  56
MET A  67
None
0.69A 5i9yA-2lleA:
undetectable
5i9yA-2lleA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mnj PROTEIN INTERACTING
WITH HSP90 1


(Saccharomyces
cerevisiae)
no annotation 3 ILE B  83
ILE B  98
MET B  38
None
0.63A 5i9yA-2mnjB:
undetectable
5i9yA-2mnjB:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0y GCN5-RELATED
N-ACETYLTRANSFERASE


(Cupriavidus
pinatubonensis)
PF00583
(Acetyltransf_1)
3 ILE A  89
ILE A 120
MET A 108
UNL  A 156 ( 4.8A)
None
None
0.65A 5i9yA-2q0yA:
undetectable
5i9yA-2q0yA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qh9 UPF0215 PROTEIN
AF_1433


(Archaeoglobus
fulgidus)
PF01949
(DUF99)
3 ILE A   9
ILE A  80
MET A  52
None
0.68A 5i9yA-2qh9A:
undetectable
5i9yA-2qh9A:
23.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens)
PF07714
(Pkinase_Tyr)
3 ILE A 683
ILE A 697
MET A 702
None
None
PTR  A 701 ( 3.5A)
0.39A 5i9yA-2qobA:
29.2
5i9yA-2qobA:
68.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
3 ILE A 737
ILE A 751
MET A 756
None
0.20A 5i9yA-2r2pA:
36.7
5i9yA-2r2pA:
68.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rij PUTATIVE
2,3,4,5-TETRAHYDROPY
RIDINE-2-CARBOXYLATE
N-
SUCCINYLTRANSFERASE


(Campylobacter
jejuni)
PF14602
(Hexapep_2)
PF14789
(THDPS_M)
PF14790
(THDPS_N)
3 ILE A 318
ILE A 313
MET A 370
None
0.67A 5i9yA-2rijA:
undetectable
5i9yA-2rijA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA


(Desulfovibrio
vulgaris)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
3 ILE B 184
ILE B 323
MET B 166
None
0.50A 5i9yA-2v4jB:
2.4
5i9yA-2v4jB:
23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,


(Mus musculus)
PF07714
(Pkinase_Tyr)
3 ILE A 683
ILE A 697
MET A 702
Q9G  A1898 ( 4.9A)
Q9G  A1898 ( 4.6A)
None
0.35A 5i9yA-2xyuA:
32.4
5i9yA-2xyuA:
71.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID


(Neisseria
gonorrhoeae)
PF00497
(SBP_bac_3)
3 ILE A  77
ILE A 232
MET A 254
None
0.65A 5i9yA-2yjpA:
undetectable
5i9yA-2yjpA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1


(Aeropyrum
pernix)
PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
3 ILE A  51
ILE A 463
MET A 332
None
0.65A 5i9yA-3a31A:
undetectable
5i9yA-3a31A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7c UNCHARACTERIZED
PROTEIN


(Shewanella
oneidensis)
PF14534
(DUF4440)
3 ILE A   6
ILE A 114
MET A  76
None
0.57A 5i9yA-3b7cA:
2.2
5i9yA-3b7cA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdr YCF58 PROTEIN

(Synechococcus
elongatus)
PF09367
(CpeS)
3 ILE A   7
ILE A  93
MET A 122
None
0.70A 5i9yA-3bdrA:
undetectable
5i9yA-3bdrA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2g SYS-1 PROTEIN

(Caenorhabditis
elegans)
no annotation 3 ILE A 371
ILE A 376
MET A 328
None
0.67A 5i9yA-3c2gA:
undetectable
5i9yA-3c2gA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cah AGGLUTININ II

(Sambucus nigra)
PF00652
(Ricin_B_lectin)
3 ILE A 238
ILE A 197
MET A 155
None
0.68A 5i9yA-3cahA:
undetectable
5i9yA-3cahA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA


(Chlorobaculum
tepidum)
PF01134
(GIDA)
PF13932
(GIDA_assoc)
3 ILE A  54
ILE A  46
MET A 424
None
0.68A 5i9yA-3cp8A:
undetectable
5i9yA-3cp8A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8u PURR TRANSCRIPTIONAL
REGULATOR


(Vibrio
parahaemolyticus)
PF13377
(Peripla_BP_3)
3 ILE A 261
ILE A 280
MET A 288
None
0.70A 5i9yA-3d8uA:
undetectable
5i9yA-3d8uA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd5 SELENIDE, WATER
DIKINASE 1


(Homo sapiens)
PF00586
(AIRS)
PF02769
(AIRS_C)
3 ILE A 170
ILE A  92
MET A 141
None
0.65A 5i9yA-3fd5A:
undetectable
5i9yA-3fd5A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn9 PUTATIVE
BETA-GALACTOSIDASE


(Bacteroides
fragilis)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
3 ILE A 346
ILE A 376
MET A 558
None
0.69A 5i9yA-3fn9A:
undetectable
5i9yA-3fn9A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fya REGULATORY PROTEIN

(Enterobacter
sp. RFL1396)
PF01381
(HTH_3)
3 ILE A  16
ILE A  56
MET A  70
None
0.69A 5i9yA-3fyaA:
undetectable
5i9yA-3fyaA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gmf PROTEIN-DISULFIDE
ISOMERASE


(Novosphingobium
aromaticivorans)
PF13462
(Thioredoxin_4)
3 ILE A 111
ILE A 161
MET A 171
None
0.70A 5i9yA-3gmfA:
undetectable
5i9yA-3gmfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpg NON-STRUCTURAL
PROTEIN 3


(Chikungunya
virus)
PF01661
(Macro)
3 ILE A 106
ILE A 152
MET A 132
None
0.71A 5i9yA-3gpgA:
undetectable
5i9yA-3gpgA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4m PROTEASOME-ACTIVATIN
G NUCLEOTIDASE


(Methanocaldococcus
jannaschii)
PF00004
(AAA)
3 ILE A 368
ILE A 411
MET A 401
None
0.54A 5i9yA-3h4mA:
undetectable
5i9yA-3h4mA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5t AMINOTRANSFERASE

(Rhodobacter
sphaeroides)
PF00202
(Aminotran_3)
3 ILE A 437
ILE A 426
MET A 355
None
0.58A 5i9yA-3i5tA:
undetectable
5i9yA-3i5tA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2


(Homo sapiens)
PF00069
(Pkinase)
PF00498
(FHA)
3 ILE A 286
ILE A 299
MET A 304
None
0.48A 5i9yA-3i6uA:
21.3
5i9yA-3i6uA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE


(Bacillus
anthracis)
PF13561
(adh_short_C2)
3 ILE A 127
ILE A 181
MET A 168
ILE  A 127 ( 0.7A)
ILE  A 181 ( 0.7A)
PHE  A 124 ( 3.8A)
0.67A 5i9yA-3iccA:
undetectable
5i9yA-3iccA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5z FEM-3 MRNA-BINDING
FACTOR 2


(Caenorhabditis
elegans)
PF00806
(PUF)
3 ILE A 421
ILE A 435
MET A 398
None
0.70A 5i9yA-3k5zA:
undetectable
5i9yA-3k5zA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmi PUTATIVE MEMBRANE
PROTEIN COG4129


(Clostridioides
difficile)
PF11728
(ArAE_1_C)
3 ILE A 196
ILE A 203
MET A 218
None
0.69A 5i9yA-3kmiA:
undetectable
5i9yA-3kmiA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krb ALDOSE REDUCTASE

(Giardia
intestinalis)
PF00248
(Aldo_ket_red)
3 ILE A  53
ILE A  68
MET A  28
None
0.62A 5i9yA-3krbA:
undetectable
5i9yA-3krbA:
22.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
3 ILE A 697
ILE A 711
MET A 716
None
0.36A 5i9yA-3kulA:
35.2
5i9yA-3kulA:
59.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A


(Shewanella
denitrificans)
PF00246
(Peptidase_M14)
3 ILE A  23
ILE A  12
MET A   1
None
0.63A 5i9yA-3l2nA:
undetectable
5i9yA-3l2nA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE


(Staphylococcus
aureus)
PF00724
(Oxidored_FMN)
3 ILE A 299
ILE A 224
MET A 254
None
0.58A 5i9yA-3l5aA:
undetectable
5i9yA-3l5aA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m66 MTERF
DOMAIN-CONTAINING
PROTEIN 1,
MITOCHONDRIAL


(Homo sapiens)
PF02536
(mTERF)
3 ILE A 215
ILE A 169
MET A 191
None
0.67A 5i9yA-3m66A:
undetectable
5i9yA-3m66A:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA


(Archaeoglobus
fulgidus)
PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
3 ILE B 173
ILE B 306
MET B 155
None
0.56A 5i9yA-3mm5B:
2.7
5i9yA-3mm5B:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2x UNCHARACTERIZED
PROTEIN YAGE


(Escherichia
coli)
PF00701
(DHDPS)
3 ILE A 173
ILE A 219
MET A 186
MCL  A 174 ( 3.6A)
MCL  A 174 ( 3.7A)
None
0.71A 5i9yA-3n2xA:
undetectable
5i9yA-3n2xA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogk CORONATINE-INSENSITI
VE PROTEIN 1


(Arabidopsis
thaliana)
no annotation 3 ILE B 505
ILE B 542
MET B 495
None
0.62A 5i9yA-3ogkB:
undetectable
5i9yA-3ogkB:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei)
PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5)
3 ILE A 472
ILE A 416
MET A 332
None
0.62A 5i9yA-3ogrA:
undetectable
5i9yA-3ogrA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4


(Saccharomyces
cerevisiae)
PF11701
(UNC45-central)
3 ILE A 335
ILE A 375
MET A 365
None
0.62A 5i9yA-3opbA:
undetectable
5i9yA-3opbA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r13 DEOXYRIBOSE-PHOSPHAT
E ALDOLASE


(Thermotoga
maritima)
PF01791
(DeoC)
3 ILE A 153
ILE A 169
MET A 197
None
0.70A 5i9yA-3r13A:
undetectable
5i9yA-3r13A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL


(Homo sapiens)
PF00271
(Helicase_C)
PF12513
(SUV3_C)
3 ILE A 370
ILE A 435
MET A 486
None
0.72A 5i9yA-3rc3A:
undetectable
5i9yA-3rc3A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh9 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(NAD(P)(+))


(Marinobacter
hydrocarbonoclasticus)
PF00171
(Aldedh)
3 ILE A   2
ILE A 189
MET A  95
None
0.70A 5i9yA-3rh9A:
undetectable
5i9yA-3rh9A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N


(Escherichia
coli)
no annotation 3 ILE N 161
ILE K  75
MET K  31
None
0.68A 5i9yA-3rkoN:
undetectable
5i9yA-3rkoN:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7y YOP PROTEINS
TRANSLOCATION
PROTEIN U


(Chlamydia
trachomatis)
PF01312
(Bac_export_2)
3 ILE A 336
ILE A 325
MET A 306
None
0.70A 5i9yA-3t7yA:
undetectable
5i9yA-3t7yA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE


(Vibrio cholerae)
PF00857
(Isochorismatase)
3 ILE A  58
ILE A 142
MET A  36
None
0.67A 5i9yA-3tb4A:
undetectable
5i9yA-3tb4A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS


(Pyrococcus
furiosus)
PF08489
(DUF1743)
3 ILE A  69
ILE A  32
MET A   1
None
0.71A 5i9yA-3u02A:
undetectable
5i9yA-3u02A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v39 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE


(Bdellovibrio
bacteriovorus)
PF02113
(Peptidase_S13)
3 ILE A  71
ILE A 402
MET A 310
None
0.71A 5i9yA-3v39A:
undetectable
5i9yA-3v39A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w25 GLYCOSIDE HYDROLASE
FAMILY 10


(Thermoanaerobacterium
saccharolyticum)
PF00331
(Glyco_hydro_10)
3 ILE A 218
ILE A 237
MET A 201
None
0.65A 5i9yA-3w25A:
undetectable
5i9yA-3w25A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whi SUBTILISIN E

(Bacillus
subtilis)
PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9)
3 ILE A 197
ILE A  73
MET A 214
None
0.65A 5i9yA-3whiA:
undetectable
5i9yA-3whiA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdr ALCOHOL
DEHYDROGENASE DOMAIN
OF THE BIFUNCTIONAL
ACETALDEHYDE
DEHYDROGENASE


(Parageobacillus
thermoglucosidasius)
PF00465
(Fe-ADH)
3 ILE A 548
ILE A 485
MET A 540
None
0.56A 5i9yA-3zdrA:
undetectable
5i9yA-3zdrA:
20.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
3 ILE A 681
ILE A 695
MET A 700
None
0.40A 5i9yA-3zfxA:
37.9
5i9yA-3zfxA:
69.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjc GTPASE IMAP FAMILY
MEMBER 7


(Homo sapiens)
PF04548
(AIG1)
3 ILE A 115
ILE A  85
MET A 127
None
0.67A 5i9yA-3zjcA:
undetectable
5i9yA-3zjcA:
21.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
3 ILE A 153
ILE A 167
MET A 172
None
0.51A 5i9yA-4aw5A:
32.1
5i9yA-4aw5A:
66.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bj6 RAP1-INTERACTING
FACTOR 2


(Saccharomyces
cerevisiae)
no annotation 3 ILE A 245
ILE A 138
MET A 195
None
0.40A 5i9yA-4bj6A:
undetectable
5i9yA-4bj6A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bsn EXPORTIN-1

(Homo sapiens)
PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C)
3 ILE A 501
ILE A 521
MET A 476
None
0.55A 5i9yA-4bsnA:
undetectable
5i9yA-4bsnA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae)
PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2)
3 ILE A  55
ILE A  39
MET A  29
None
0.71A 5i9yA-4c22A:
undetectable
5i9yA-4c22A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN


(Helicobacter
pylori)
no annotation 3 ILE P 449
ILE P 463
MET P 405
None
0.64A 5i9yA-4dvyP:
undetectable
5i9yA-4dvyP:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvz CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN


(Helicobacter
pylori)
no annotation 3 ILE A 449
ILE A 463
MET A 405
None
0.67A 5i9yA-4dvzA:
undetectable
5i9yA-4dvzA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dz6 NUCLEOSIDE
DIPHOSPHATE KINASE


(Borreliella
burgdorferi)
PF00334
(NDK)
3 ILE A  22
ILE A 133
MET A  41
None
0.68A 5i9yA-4dz6A:
undetectable
5i9yA-4dz6A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ell RETINOBLASTOMA-ASSOC
IATED PROTEIN


(Homo sapiens)
PF01857
(RB_B)
PF01858
(RB_A)
3 ILE A 724
ILE A 753
MET A 708
None
0.68A 5i9yA-4ellA:
undetectable
5i9yA-4ellA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN


(Ochrobactrum
sp. T63)
PF00561
(Abhydrolase_1)
3 ILE A  30
ILE A 109
MET A  84
None
0.65A 5i9yA-4g8dA:
undetectable
5i9yA-4g8dA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gis ENOLASE

(Vibrio harveyi)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 ILE A  25
ILE A 100
MET A 369
None
0.65A 5i9yA-4gisA:
undetectable
5i9yA-4gisA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl6 HYPOTHETICAL PROTEIN

([Ruminococcus]
gnavus)
PF16440
(DUF5037)
3 ILE A 128
ILE A 142
MET A 107
None
0.64A 5i9yA-4gl6A:
undetectable
5i9yA-4gl6A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE


(Acinetobacter
sp. ADP1)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
3 ILE A 214
ILE A 257
MET A 229
None
0.66A 5i9yA-4gtnA:
undetectable
5i9yA-4gtnA:
22.11