SIMILAR PATTERNS OF AMINO ACIDS FOR 5I9Y_A_1N1A1001_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b6r | PROTEIN(N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDESYNTHETASE) (Escherichiacoli) |
PF02222(ATP-grasp) | 3 | ILE A 213ILE A 76MET A 225 | None | 0.50A | 5i9yA-1b6rA:undetectable | 5i9yA-1b6rA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bx0 | PROTEIN(FERREDOXIN:NADP+OXIDOREDUCTASE) (Spinaciaoleracea) |
PF00175(NAD_binding_1) | 3 | ILE A 166ILE A 281MET A 261 | None | 0.69A | 5i9yA-1bx0A:undetectable | 5i9yA-1bx0A:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cle | CHOLESTEROL ESTERASE ([Candida]cylindracea) |
PF00135(COesterase) | 3 | ILE A 466ILE A 238MET A 503 | None | 0.63A | 5i9yA-1cleA:undetectable | 5i9yA-1cleA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1crl | LIPASE (Diutina rugosa) |
PF00135(COesterase) | 3 | ILE A 466ILE A 238MET A 503 | None | 0.67A | 5i9yA-1crlA:undetectable | 5i9yA-1crlA:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ezw | COENZYMEF420-DEPENDENTN5,N10-METHYLENETETRAHYDROMETHANOPTERINREDUCTASE (Methanopyruskandleri) |
PF00296(Bac_luciferase) | 3 | ILE A 131ILE A 93MET A 182 | None | 0.65A | 5i9yA-1ezwA:undetectable | 5i9yA-1ezwA:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gm5 | RECG (Thermotogamaritima) |
PF00270(DEAD)PF00271(Helicase_C)PF17190(RecG_N)PF17191(RecG_wedge) | 3 | ILE A 649ILE A 663MET A 619 | None | 0.52A | 5i9yA-1gm5A:undetectable | 5i9yA-1gm5A:17.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gz7 | LIPASE 2 (Diutina rugosa) |
PF00135(COesterase) | 3 | ILE A 466ILE A 238MET A 503 | None | 0.67A | 5i9yA-1gz7A:undetectable | 5i9yA-1gz7A:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hle | HORSE LEUKOCYTEELASTASE INHIBITOR (Equus caballus) |
PF00079(Serpin) | 3 | ILE A 333ILE A 169MET A 177 | None | 0.60A | 5i9yA-1hleA:undetectable | 5i9yA-1hleA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hv2 | ELONGIN C (Saccharomycescerevisiae) |
PF03931(Skp1_POZ) | 3 | ILE A 44ILE A 18MET A 32 | None | 0.66A | 5i9yA-1hv2A:undetectable | 5i9yA-1hv2A:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hxj | BETA-GLUCOSIDASE (Zea mays) |
PF00232(Glyco_hydro_1) | 3 | ILE A 397ILE A 440MET A 388 | None | 0.68A | 5i9yA-1hxjA:undetectable | 5i9yA-1hxjA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ji0 | ABC TRANSPORTER (Thermotogamaritima) |
PF00005(ABC_tran) | 3 | ILE A 149ILE A 91MET A 162 | None | 0.71A | 5i9yA-1ji0A:undetectable | 5i9yA-1ji0A:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jqg | CARBOXYPEPTIDASE A (Helicoverpaarmigera) |
PF00246(Peptidase_M14)PF02244(Propep_M14) | 3 | ILE A 297ILE A 202MET A 64 | None | 0.66A | 5i9yA-1jqgA:undetectable | 5i9yA-1jqgA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p8r | ARGINASE 1 (Rattusnorvegicus) |
PF00491(Arginase) | 3 | ILE A 177ILE A 174MET A 212 | None | 0.64A | 5i9yA-1p8rA:undetectable | 5i9yA-1p8rA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pl8 | HUMAN SORBITOLDEHYDROGENASE (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 3 | ILE A 93ILE A 154MET A 38 | None | 0.70A | 5i9yA-1pl8A:undetectable | 5i9yA-1pl8A:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ps6 | 4-HYDROXYTHREONINE-4-PHOSPHATEDEHYDROGENASE (Escherichiacoli) |
PF04166(PdxA) | 3 | ILE A 185ILE A 226MET A 238 | None | 0.67A | 5i9yA-1ps6A:undetectable | 5i9yA-1ps6A:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sb7 | TRNA PSEUDOURIDINESYNTHASE D (Escherichiacoli) |
PF01142(TruD) | 3 | ILE A 44ILE A 68MET A 98 | None | 0.69A | 5i9yA-1sb7A:undetectable | 5i9yA-1sb7A:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1seh | DEOXYURIDINE5'-TRIPHOSPHATENUCLEOTIDOHYDROLASE (Escherichiacoli) |
PF00692(dUTPase) | 3 | ILE A 99ILE A 80MET A 68 | NoneNoneUMP A 777 (-4.4A) | 0.65A | 5i9yA-1sehA:undetectable | 5i9yA-1sehA:16.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1txz | HYPOTHETICAL 32.1KDA PROTEIN INADH3-RCA1 INTERGENICREGION (Saccharomycescerevisiae) |
PF14519(Macro_2) | 3 | ILE A 19ILE A 185MET A 217 | None | 0.71A | 5i9yA-1txzA:undetectable | 5i9yA-1txzA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u8x | MALTOSE-6'-PHOSPHATEGLUCOSIDASE (Bacillussubtilis) |
PF02056(Glyco_hydro_4)PF11975(Glyco_hydro_4C) | 3 | ILE X 21ILE X 50MET X 84 | None | 0.70A | 5i9yA-1u8xX:undetectable | 5i9yA-1u8xX:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uc8 | LYSINE BIOSYNTHESISENZYME (Thermusthermophilus) |
PF08443(RimK) | 3 | ILE A 271ILE A 4MET A 254 | None | 0.62A | 5i9yA-1uc8A:undetectable | 5i9yA-1uc8A:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wl4 | ACETYL-COENZYME AACETYLTRANSFERASE 2 (Homo sapiens) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 3 | ILE A 390ILE A 362MET A 90 | None | 0.68A | 5i9yA-1wl4A:undetectable | 5i9yA-1wl4A:23.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y0y | FRV OPERON PROTEINFRVX (Pyrococcushorikoshii) |
PF05343(Peptidase_M42) | 3 | ILE A 65ILE A 37MET A 341 | None | 0.63A | 5i9yA-1y0yA:undetectable | 5i9yA-1y0yA:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yb2 | HYPOTHETICAL PROTEINTA0852 (Thermoplasmaacidophilum) |
PF08704(GCD14) | 3 | ILE A 164ILE A 167MET A 104 | None | 0.67A | 5i9yA-1yb2A:undetectable | 5i9yA-1yb2A:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yt5 | INORGANICPOLYPHOSPHATE/ATP-NAD KINASE (Thermotogamaritima) |
PF01513(NAD_kinase) | 3 | ILE A 224ILE A 180MET A 211 | None | 0.71A | 5i9yA-1yt5A:undetectable | 5i9yA-1yt5A:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ywk | 4-DEOXY-L-THREO-5-HEXOSULOSE-URONATEKETOL-ISOMERASE 1 (Enterococcusfaecalis) |
PF04962(KduI) | 3 | ILE A1079ILE A1142MET A1177 | None | 0.65A | 5i9yA-1ywkA:undetectable | 5i9yA-1ywkA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zbt | PEPTIDE CHAINRELEASE FACTOR 1 (Streptococcusmutans) |
PF00472(RF-1)PF03462(PCRF) | 3 | ILE A 274ILE A 254MET A 258 | None | 0.70A | 5i9yA-1zbtA:undetectable | 5i9yA-1zbtA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zlt | SERINE/THREONINE-PROTEIN KINASE CHK1 (Homo sapiens) |
PF00069(Pkinase) | 3 | ILE A 126ILE A 146MET A 61 | None | 0.54A | 5i9yA-1zltA:21.0 | 5i9yA-1zltA:28.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d7d | UVRABC SYSTEMPROTEIN B (Bacillussubtilis) |
PF00271(Helicase_C)PF02151(UVR)PF04851(ResIII)PF12344(UvrB) | 3 | ILE A 431ILE A 468MET A 457 | None | 0.64A | 5i9yA-2d7dA:undetectable | 5i9yA-2d7dA:18.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ep5 | 350AA LONGHYPOTHETICALASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Sulfurisphaeratokodaii) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 3 | ILE A 248ILE A 166MET A 156 | None | 0.66A | 5i9yA-2ep5A:undetectable | 5i9yA-2ep5A:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f9g | MITOGEN-ACTIVATEDPROTEIN KINASE FUS3 (Saccharomycescerevisiae) |
PF00069(Pkinase) | 3 | ILE A 72ILE A 91MET A 96 | None | 0.53A | 5i9yA-2f9gA:16.9 | 5i9yA-2f9gA:25.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ftw | DIHYDROPYRIMIDINEAMIDOHYDROLASE (Dictyosteliumdiscoideum) |
PF01979(Amidohydro_1) | 3 | ILE A 134ILE A 102MET A 145 | KCX A 158 ( 4.2A)NoneNone | 0.69A | 5i9yA-2ftwA:undetectable | 5i9yA-2ftwA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2grk | EVM001 (Ectromeliavirus) |
PF02250(Orthopox_35kD) | 3 | ILE A 28ILE A 169MET A 79 | None | 0.60A | 5i9yA-2grkA:undetectable | 5i9yA-2grkA:20.40 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hen | EPHRIN TYPE-BRECEPTOR 2 (Mus musculus) |
PF07714(Pkinase_Tyr) | 3 | ILE A 691ILE A 705MET A 710 | None | 0.19A | 5i9yA-2henA:37.5 | 5i9yA-2henA:67.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iut | DNA TRANSLOCASE FTSK (Pseudomonasaeruginosa) |
PF01580(FtsK_SpoIIIE) | 3 | ILE A 627ILE A 495MET A 479 | None | 0.67A | 5i9yA-2iutA:undetectable | 5i9yA-2iutA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jfq | GLUTAMATE RACEMASE (Staphylococcusaureus) |
PF01177(Asp_Glu_race) | 3 | ILE A 248ILE A 36MET A 153 | None | 0.70A | 5i9yA-2jfqA:undetectable | 5i9yA-2jfqA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kok | ARSENATE REDUCTASE (Brucellaabortus) |
PF03960(ArsC) | 3 | ILE A 9ILE A 30MET A 18 | None | 0.59A | 5i9yA-2kokA:undetectable | 5i9yA-2kokA:17.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lle | CHEMOTAXIS PROTEINCHEY, IMIDAZOLEGLYCEROL PHOSPHATESYNTHASE SUBUNITHISF CHIMERA (Thermotogamaritima) |
PF00072(Response_reg)PF00977(His_biosynth) | 3 | ILE A 33ILE A 80MET A 67 | None | 0.68A | 5i9yA-2lleA:undetectable | 5i9yA-2lleA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lle | CHEMOTAXIS PROTEINCHEY, IMIDAZOLEGLYCEROL PHOSPHATESYNTHASE SUBUNITHISF CHIMERA (Thermotogamaritima) |
PF00072(Response_reg)PF00977(His_biosynth) | 3 | ILE A 41ILE A 56MET A 67 | None | 0.69A | 5i9yA-2lleA:undetectable | 5i9yA-2lleA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mnj | PROTEIN INTERACTINGWITH HSP90 1 (Saccharomycescerevisiae) |
no annotation | 3 | ILE B 83ILE B 98MET B 38 | None | 0.63A | 5i9yA-2mnjB:undetectable | 5i9yA-2mnjB:15.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q0y | GCN5-RELATEDN-ACETYLTRANSFERASE (Cupriaviduspinatubonensis) |
PF00583(Acetyltransf_1) | 3 | ILE A 89ILE A 120MET A 108 | UNL A 156 ( 4.8A)NoneNone | 0.65A | 5i9yA-2q0yA:undetectable | 5i9yA-2q0yA:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qh9 | UPF0215 PROTEINAF_1433 (Archaeoglobusfulgidus) |
PF01949(DUF99) | 3 | ILE A 9ILE A 80MET A 52 | None | 0.68A | 5i9yA-2qh9A:undetectable | 5i9yA-2qh9A:23.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2qob | EPHRIN RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 3 | ILE A 683ILE A 697MET A 702 | NoneNonePTR A 701 ( 3.5A) | 0.39A | 5i9yA-2qobA:29.2 | 5i9yA-2qobA:68.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2r2p | EPHRIN TYPE-ARECEPTOR 5 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 3 | ILE A 737ILE A 751MET A 756 | None | 0.20A | 5i9yA-2r2pA:36.7 | 5i9yA-2r2pA:68.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rij | PUTATIVE2,3,4,5-TETRAHYDROPYRIDINE-2-CARBOXYLATEN-SUCCINYLTRANSFERASE (Campylobacterjejuni) |
PF14602(Hexapep_2)PF14789(THDPS_M)PF14790(THDPS_N) | 3 | ILE A 318ILE A 313MET A 370 | None | 0.67A | 5i9yA-2rijA:undetectable | 5i9yA-2rijA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v4j | SULFITE REDUCTASE,DISSIMILATORY-TYPESUBUNIT BETA (Desulfovibriovulgaris) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 3 | ILE B 184ILE B 323MET B 166 | None | 0.50A | 5i9yA-2v4jB:2.4 | 5i9yA-2v4jB:23.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2xyu | EPHRIN TYPE-ARECEPTOR 4, (Mus musculus) |
PF07714(Pkinase_Tyr) | 3 | ILE A 683ILE A 697MET A 702 | Q9G A1898 ( 4.9A)Q9G A1898 ( 4.6A)None | 0.35A | 5i9yA-2xyuA:32.4 | 5i9yA-2xyuA:71.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yjp | PUTATIVE ABCTRANSPORTER,PERIPLASMIC BINDINGPROTEIN, AMINO ACID (Neisseriagonorrhoeae) |
PF00497(SBP_bac_3) | 3 | ILE A 77ILE A 232MET A 254 | None | 0.65A | 5i9yA-2yjpA:undetectable | 5i9yA-2yjpA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a31 | PROBABLETHREONYL-TRNASYNTHETASE 1 (Aeropyrumpernix) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon) | 3 | ILE A 51ILE A 463MET A 332 | None | 0.65A | 5i9yA-3a31A:undetectable | 5i9yA-3a31A:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b7c | UNCHARACTERIZEDPROTEIN (Shewanellaoneidensis) |
PF14534(DUF4440) | 3 | ILE A 6ILE A 114MET A 76 | None | 0.57A | 5i9yA-3b7cA:2.2 | 5i9yA-3b7cA:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bdr | YCF58 PROTEIN (Synechococcuselongatus) |
PF09367(CpeS) | 3 | ILE A 7ILE A 93MET A 122 | None | 0.70A | 5i9yA-3bdrA:undetectable | 5i9yA-3bdrA:18.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c2g | SYS-1 PROTEIN (Caenorhabditiselegans) |
no annotation | 3 | ILE A 371ILE A 376MET A 328 | None | 0.67A | 5i9yA-3c2gA:undetectable | 5i9yA-3c2gA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cah | AGGLUTININ II (Sambucus nigra) |
PF00652(Ricin_B_lectin) | 3 | ILE A 238ILE A 197MET A 155 | None | 0.68A | 5i9yA-3cahA:undetectable | 5i9yA-3cahA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cp8 | TRNA URIDINE5-CARBOXYMETHYLAMINOMETHYL MODIFICATIONENZYME GIDA (Chlorobaculumtepidum) |
PF01134(GIDA)PF13932(GIDA_assoc) | 3 | ILE A 54ILE A 46MET A 424 | None | 0.68A | 5i9yA-3cp8A:undetectable | 5i9yA-3cp8A:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d8u | PURR TRANSCRIPTIONALREGULATOR (Vibrioparahaemolyticus) |
PF13377(Peripla_BP_3) | 3 | ILE A 261ILE A 280MET A 288 | None | 0.70A | 5i9yA-3d8uA:undetectable | 5i9yA-3d8uA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fd5 | SELENIDE, WATERDIKINASE 1 (Homo sapiens) |
PF00586(AIRS)PF02769(AIRS_C) | 3 | ILE A 170ILE A 92MET A 141 | None | 0.65A | 5i9yA-3fd5A:undetectable | 5i9yA-3fd5A:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fn9 | PUTATIVEBETA-GALACTOSIDASE (Bacteroidesfragilis) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N) | 3 | ILE A 346ILE A 376MET A 558 | None | 0.69A | 5i9yA-3fn9A:undetectable | 5i9yA-3fn9A:18.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fya | REGULATORY PROTEIN (Enterobactersp. RFL1396) |
PF01381(HTH_3) | 3 | ILE A 16ILE A 56MET A 70 | None | 0.69A | 5i9yA-3fyaA:undetectable | 5i9yA-3fyaA:17.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gmf | PROTEIN-DISULFIDEISOMERASE (Novosphingobiumaromaticivorans) |
PF13462(Thioredoxin_4) | 3 | ILE A 111ILE A 161MET A 171 | None | 0.70A | 5i9yA-3gmfA:undetectable | 5i9yA-3gmfA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gpg | NON-STRUCTURALPROTEIN 3 (Chikungunyavirus) |
PF01661(Macro) | 3 | ILE A 106ILE A 152MET A 132 | None | 0.71A | 5i9yA-3gpgA:undetectable | 5i9yA-3gpgA:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h4m | PROTEASOME-ACTIVATING NUCLEOTIDASE (Methanocaldococcusjannaschii) |
PF00004(AAA) | 3 | ILE A 368ILE A 411MET A 401 | None | 0.54A | 5i9yA-3h4mA:undetectable | 5i9yA-3h4mA:24.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i5t | AMINOTRANSFERASE (Rhodobactersphaeroides) |
PF00202(Aminotran_3) | 3 | ILE A 437ILE A 426MET A 355 | None | 0.58A | 5i9yA-3i5tA:undetectable | 5i9yA-3i5tA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i6u | SERINE/THREONINE-PROTEIN KINASE CHK2 (Homo sapiens) |
PF00069(Pkinase)PF00498(FHA) | 3 | ILE A 286ILE A 299MET A 304 | None | 0.48A | 5i9yA-3i6uA:21.3 | 5i9yA-3i6uA:23.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3icc | PUTATIVE3-OXOACYL-(ACYLCARRIER PROTEIN)REDUCTASE (Bacillusanthracis) |
PF13561(adh_short_C2) | 3 | ILE A 127ILE A 181MET A 168 | ILE A 127 ( 0.7A)ILE A 181 ( 0.7A)PHE A 124 ( 3.8A) | 0.67A | 5i9yA-3iccA:undetectable | 5i9yA-3iccA:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k5z | FEM-3 MRNA-BINDINGFACTOR 2 (Caenorhabditiselegans) |
PF00806(PUF) | 3 | ILE A 421ILE A 435MET A 398 | None | 0.70A | 5i9yA-3k5zA:undetectable | 5i9yA-3k5zA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kmi | PUTATIVE MEMBRANEPROTEIN COG4129 (Clostridioidesdifficile) |
PF11728(ArAE_1_C) | 3 | ILE A 196ILE A 203MET A 218 | None | 0.69A | 5i9yA-3kmiA:undetectable | 5i9yA-3kmiA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3krb | ALDOSE REDUCTASE (Giardiaintestinalis) |
PF00248(Aldo_ket_red) | 3 | ILE A 53ILE A 68MET A 28 | None | 0.62A | 5i9yA-3krbA:undetectable | 5i9yA-3krbA:22.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kul | EPHRIN TYPE-ARECEPTOR 8 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 3 | ILE A 697ILE A 711MET A 716 | None | 0.36A | 5i9yA-3kulA:35.2 | 5i9yA-3kulA:59.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l2n | PEPTIDASE M14,CARBOXYPEPTIDASE A (Shewanelladenitrificans) |
PF00246(Peptidase_M14) | 3 | ILE A 23ILE A 12MET A 1 | None | 0.63A | 5i9yA-3l2nA:undetectable | 5i9yA-3l2nA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l5a | NADH/FLAVINOXIDOREDUCTASE/NADHOXIDASE (Staphylococcusaureus) |
PF00724(Oxidored_FMN) | 3 | ILE A 299ILE A 224MET A 254 | None | 0.58A | 5i9yA-3l5aA:undetectable | 5i9yA-3l5aA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m66 | MTERFDOMAIN-CONTAININGPROTEIN 1,MITOCHONDRIAL (Homo sapiens) |
PF02536(mTERF) | 3 | ILE A 215ILE A 169MET A 191 | None | 0.67A | 5i9yA-3m66A:undetectable | 5i9yA-3m66A:25.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mm5 | SULFITE REDUCTASE,DISSIMILATORY-TYPESUBUNIT BETA (Archaeoglobusfulgidus) |
PF00037(Fer4)PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 3 | ILE B 173ILE B 306MET B 155 | None | 0.56A | 5i9yA-3mm5B:2.7 | 5i9yA-3mm5B:23.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n2x | UNCHARACTERIZEDPROTEIN YAGE (Escherichiacoli) |
PF00701(DHDPS) | 3 | ILE A 173ILE A 219MET A 186 | MCL A 174 ( 3.6A)MCL A 174 ( 3.7A)None | 0.71A | 5i9yA-3n2xA:undetectable | 5i9yA-3n2xA:24.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ogk | CORONATINE-INSENSITIVE PROTEIN 1 (Arabidopsisthaliana) |
no annotation | 3 | ILE B 505ILE B 542MET B 495 | None | 0.62A | 5i9yA-3ogkB:undetectable | 5i9yA-3ogkB:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ogr | BETA-GALACTOSIDASE (Trichodermareesei) |
PF01301(Glyco_hydro_35)PF10435(BetaGal_dom2)PF13363(BetaGal_dom3)PF13364(BetaGal_dom4_5) | 3 | ILE A 472ILE A 416MET A 332 | None | 0.62A | 5i9yA-3ogrA:undetectable | 5i9yA-3ogrA:15.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3opb | SWI5-DEPENDENT HOEXPRESSION PROTEIN 4 (Saccharomycescerevisiae) |
PF11701(UNC45-central) | 3 | ILE A 335ILE A 375MET A 365 | None | 0.62A | 5i9yA-3opbA:undetectable | 5i9yA-3opbA:17.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r13 | DEOXYRIBOSE-PHOSPHATE ALDOLASE (Thermotogamaritima) |
PF01791(DeoC) | 3 | ILE A 153ILE A 169MET A 197 | None | 0.70A | 5i9yA-3r13A:undetectable | 5i9yA-3r13A:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rc3 | ATP-DEPENDENT RNAHELICASE SUPV3L1,MITOCHONDRIAL (Homo sapiens) |
PF00271(Helicase_C)PF12513(SUV3_C) | 3 | ILE A 370ILE A 435MET A 486 | None | 0.72A | 5i9yA-3rc3A:undetectable | 5i9yA-3rc3A:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rh9 | SUCCINATE-SEMIALDEHYDE DEHYDROGENASE(NAD(P)(+)) (Marinobacterhydrocarbonoclasticus) |
PF00171(Aldedh) | 3 | ILE A 2ILE A 189MET A 95 | None | 0.70A | 5i9yA-3rh9A:undetectable | 5i9yA-3rh9A:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT KNADH-QUINONEOXIDOREDUCTASESUBUNIT N (Escherichiacoli) |
no annotation | 3 | ILE N 161ILE K 75MET K 31 | None | 0.68A | 5i9yA-3rkoN:undetectable | 5i9yA-3rkoN:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t7y | YOP PROTEINSTRANSLOCATIONPROTEIN U (Chlamydiatrachomatis) |
PF01312(Bac_export_2) | 3 | ILE A 336ILE A 325MET A 306 | None | 0.70A | 5i9yA-3t7yA:undetectable | 5i9yA-3t7yA:16.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tb4 | VIBRIOBACTIN-SPECIFIC ISOCHORISMATASE (Vibrio cholerae) |
PF00857(Isochorismatase) | 3 | ILE A 58ILE A 142MET A 36 | None | 0.67A | 5i9yA-3tb4A:undetectable | 5i9yA-3tb4A:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u02 | PUTATIVETRANSCRIPTION-ASSOCIATED PROTEIN TFIIS (Pyrococcusfuriosus) |
PF08489(DUF1743) | 3 | ILE A 69ILE A 32MET A 1 | None | 0.71A | 5i9yA-3u02A:undetectable | 5i9yA-3u02A:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v39 | D-ALANYL-D-ALANINECARBOXYPEPTIDASE (Bdellovibriobacteriovorus) |
PF02113(Peptidase_S13) | 3 | ILE A 71ILE A 402MET A 310 | None | 0.71A | 5i9yA-3v39A:undetectable | 5i9yA-3v39A:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w25 | GLYCOSIDE HYDROLASEFAMILY 10 (Thermoanaerobacteriumsaccharolyticum) |
PF00331(Glyco_hydro_10) | 3 | ILE A 218ILE A 237MET A 201 | None | 0.65A | 5i9yA-3w25A:undetectable | 5i9yA-3w25A:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3whi | SUBTILISIN E (Bacillussubtilis) |
PF00082(Peptidase_S8)PF05922(Inhibitor_I9) | 3 | ILE A 197ILE A 73MET A 214 | None | 0.65A | 5i9yA-3whiA:undetectable | 5i9yA-3whiA:22.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zdr | ALCOHOLDEHYDROGENASE DOMAINOF THE BIFUNCTIONALACETALDEHYDEDEHYDROGENASE (Parageobacillusthermoglucosidasius) |
PF00465(Fe-ADH) | 3 | ILE A 548ILE A 485MET A 540 | None | 0.56A | 5i9yA-3zdrA:undetectable | 5i9yA-3zdrA:20.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zfx | EPHRIN TYPE-BRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 3 | ILE A 681ILE A 695MET A 700 | None | 0.40A | 5i9yA-3zfxA:37.9 | 5i9yA-3zfxA:69.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zjc | GTPASE IMAP FAMILYMEMBER 7 (Homo sapiens) |
PF04548(AIG1) | 3 | ILE A 115ILE A 85MET A 127 | None | 0.67A | 5i9yA-3zjcA:undetectable | 5i9yA-3zjcA:21.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4aw5 | EPHRIN TYPE-BRECEPTOR 4 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 3 | ILE A 153ILE A 167MET A 172 | None | 0.51A | 5i9yA-4aw5A:32.1 | 5i9yA-4aw5A:66.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bj6 | RAP1-INTERACTINGFACTOR 2 (Saccharomycescerevisiae) |
no annotation | 3 | ILE A 245ILE A 138MET A 195 | None | 0.40A | 5i9yA-4bj6A:undetectable | 5i9yA-4bj6A:25.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bsn | EXPORTIN-1 (Homo sapiens) |
PF03810(IBN_N)PF08389(Xpo1)PF08767(CRM1_C) | 3 | ILE A 501ILE A 521MET A 476 | None | 0.55A | 5i9yA-4bsnA:undetectable | 5i9yA-4bsnA:13.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c22 | L-FUCOSE ISOMERASE (Streptococcuspneumoniae) |
PF02952(Fucose_iso_C)PF07881(Fucose_iso_N1)PF07882(Fucose_iso_N2) | 3 | ILE A 55ILE A 39MET A 29 | None | 0.71A | 5i9yA-4c22A:undetectable | 5i9yA-4c22A:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dvy | CYTOTOXICITY-ASSOCIATED IMMUNODOMINANTANTIGEN (Helicobacterpylori) |
no annotation | 3 | ILE P 449ILE P 463MET P 405 | None | 0.64A | 5i9yA-4dvyP:undetectable | 5i9yA-4dvyP:15.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dvz | CYTOTOXICITY-ASSOCIATED IMMUNODOMINANTANTIGEN (Helicobacterpylori) |
no annotation | 3 | ILE A 449ILE A 463MET A 405 | None | 0.67A | 5i9yA-4dvzA:undetectable | 5i9yA-4dvzA:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dz6 | NUCLEOSIDEDIPHOSPHATE KINASE (Borreliellaburgdorferi) |
PF00334(NDK) | 3 | ILE A 22ILE A 133MET A 41 | None | 0.68A | 5i9yA-4dz6A:undetectable | 5i9yA-4dz6A:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ell | RETINOBLASTOMA-ASSOCIATED PROTEIN (Homo sapiens) |
PF01857(RB_B)PF01858(RB_A) | 3 | ILE A 724ILE A 753MET A 708 | None | 0.68A | 5i9yA-4ellA:undetectable | 5i9yA-4ellA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g8d | ALPHA/BETA HYDROLASEFOLD PROTEIN (Ochrobactrumsp. T63) |
PF00561(Abhydrolase_1) | 3 | ILE A 30ILE A 109MET A 84 | None | 0.65A | 5i9yA-4g8dA:undetectable | 5i9yA-4g8dA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gis | ENOLASE (Vibrio harveyi) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | ILE A 25ILE A 100MET A 369 | None | 0.65A | 5i9yA-4gisA:undetectable | 5i9yA-4gisA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gl6 | HYPOTHETICAL PROTEIN ([Ruminococcus]gnavus) |
PF16440(DUF5037) | 3 | ILE A 128ILE A 142MET A 107 | None | 0.64A | 5i9yA-4gl6A:undetectable | 5i9yA-4gl6A:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gtn | ANTHRANILATEPHOSPHORIBOSYLTRANSFERASE (Acinetobactersp. ADP1) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N) | 3 | ILE A 214ILE A 257MET A 229 | None | 0.66A | 5i9yA-4gtnA:undetectable | 5i9yA-4gtnA:22.11 |