SIMILAR PATTERNS OF AMINO ACIDS FOR 5I9Y_A_1N1A1001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 428
LYS A 430
THR A 474
TYR A 476
GLY A 480
GLU A 488
LEU A 528
 None
 1.13A 5i9yA-1k2pA:
24.4		 5i9yA-1k2pA:
39.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 428
THR A 474
TYR A 476
GLY A 480
GLU A 488
LEU A 528
SER A 538
 None
 1.06A 5i9yA-1k2pA:
24.4		 5i9yA-1k2pA:
39.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 ILE A 201
ALA A 220
LYS A 222
GLU A 236
MET A 240
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.86A 5i9yA-1k9aA:
31.7		 5i9yA-1k9aA:
27.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 ILE A 201
ALA A 220
LYS A 222
THR A 266
TYR A 268
GLY A 272
LEU A 321
SER A 331
 None
 0.64A 5i9yA-1k9aA:
31.7		 5i9yA-1k9aA:
27.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ALA A 288
LYS A 290
MET A 309
THR A 334
GLY A 340
GLU A 348
LEU A 389
 P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
None
P16  A   2 (-4.4A)
 0.83A 5i9yA-1opkA:
31.0		 5i9yA-1opkA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 ILE A 211
ALA A 230
LYS A 232
GLU A 245
TYR A 282
GLY A 286
LEU A 340
 PY1  A 700 (-3.6A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.6A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
 0.65A 5i9yA-1py5A:
26.1		 5i9yA-1py5A:
26.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 369
ALA A 389
LYS A 391
GLY A 441
LEU A 489
SER A 499
 None
 0.64A 5i9yA-1snxA:
24.8		 5i9yA-1snxA:
39.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 621
LYS A 623
GLU A 640
THR A 670
TYR A 672
GLY A 676
LEU A 799
 STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
 0.71A 5i9yA-1t46A:
33.5		 5i9yA-1t46A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  36
LYS A  38
TYR A  86
GLY A  90
LEU A 137
SER A 147
 HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.5A)
 0.63A 5i9yA-1zltA:
21.0		 5i9yA-1zltA:
28.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA X  37
LYS X  39
GLU X  54
MET X  58
THR X  82
TYR X  84
GLY X  88
LEU X 137
 STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-4.1A)
STU  X 902 (-4.6A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.77A 5i9yA-2dq7X:
31.6		 5i9yA-2dq7X:
41.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 293
LYS A 295
THR A 338
TYR A 340
GLY A 344
LEU A 393
 H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.48A 5i9yA-2h8hA:
30.4		 5i9yA-2h8hA:
26.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 ILE A 635
ALA A 659
GLU A 678
MET A 682
THR A 707
GLY A 713
LEU A 761
SER A 771
 ADP  A 400 (-4.9A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.72A 5i9yA-2henA:
37.5		 5i9yA-2henA:
67.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 ILE A 635
ALA A 659
LYS A 661
GLU A 678
MET A 682
THR A 707
LEU A 761
SER A 771
 ADP  A 400 (-4.9A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.75A 5i9yA-2henA:
37.5		 5i9yA-2henA:
67.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 271
LYS A 273
GLU A 288
MET A 292
THR A 316
GLY A 322
LEU A 371
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.49A 5i9yA-2hk5A:
25.2		 5i9yA-2hk5A:
41.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 269
LYS A 271
MET A 290
THR A 315
GLY A 321
GLU A 329
LEU A 370
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-3.4A)
None
None
GIN  A 600 (-4.7A)
 0.74A 5i9yA-2hz0A:
30.9		 5i9yA-2hz0A:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 ILE A 428
ALA A 452
LYS A 454
GLU A 471
MET A 475
GLY A 505
LEU A 553
 BII  A1687 (-3.8A)
BII  A1687 (-3.5A)
BII  A1687 (-2.9A)
None
None
BII  A1687 (-3.6A)
BII  A1687 (-4.2A)
 0.63A 5i9yA-2jkmA:
33.6		 5i9yA-2jkmA:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 271
LYS A 273
GLU A 288
MET A 292
THR A 316
TYR A 318
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
 0.58A 5i9yA-2og8A:
32.1		 5i9yA-2og8A:
40.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 271
LYS A 273
MET A 292
THR A 316
TYR A 318
GLY A 322
LEU A 371
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
 0.57A 5i9yA-2og8A:
32.1		 5i9yA-2og8A:
40.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 614
LYS A 616
THR A 663
TYR A 665
GLY A 669
LEU A 785
 None
 0.62A 5i9yA-2ogvA:
22.3		 5i9yA-2ogvA:
35.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 515
LYS A 517
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
 None
 1.02A 5i9yA-2psqA:
32.2		 5i9yA-2psqA:
31.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		6 ILE B  47
ALA B  67
GLU B  85
TYR B 116
GLY B 120
LEU B 171
 None
 0.50A 5i9yA-2qkwB:
24.4		 5i9yA-2qkwB:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		6 ILE B  47
ALA B  67
LYS B  69
GLU B  85
TYR B 116
GLY B 120
 None
 0.67A 5i9yA-2qkwB:
24.4		 5i9yA-2qkwB:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 215
LYS A 217
GLU A 230
THR A 265
GLY A 271
LEU A 328
 ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
 0.55A 5i9yA-2qluA:
24.9		 5i9yA-2qluA:
24.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 651
LYS A 653
GLU A 670
MET A 674
THR A 699
GLY A 705
LEU A 753
SER A 763
 PTR  A 701 ( 4.7A)
None
None
None
None
None
None
None
 0.74A 5i9yA-2qobA:
29.2		 5i9yA-2qobA:
68.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		9 ILE A 681
ALA A 705
GLU A 724
MET A 728
THR A 753
TYR A 755
GLY A 759
LEU A 807
SER A 817
 None
 0.55A 5i9yA-2r2pA:
36.7		 5i9yA-2r2pA:
68.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		9 ILE A 681
ALA A 705
LYS A 707
GLU A 724
MET A 728
TYR A 755
GLY A 759
LEU A 807
SER A 817
 None
 0.68A 5i9yA-2r2pA:
36.7		 5i9yA-2r2pA:
68.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 749
LYS A 751
THR A 796
GLY A 802
GLU A 810
LEU A 850
 GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
None
GW7  A   1 (-4.2A)
 0.64A 5i9yA-2r4bA:
27.1		 5i9yA-2r4bA:
38.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  82
ALA A 103
LYS A 105
GLU A 124
MET A 128
TYR A 155
GLY A 159
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
None
ANP  A1480 ( 4.9A)
None
 0.87A 5i9yA-2v55A:
19.0		 5i9yA-2v55A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  82
ALA A 103
LYS A 105
MET A 128
TYR A 155
GLY A 159
LEU A 205
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
ANP  A1480 ( 4.9A)
None
ANP  A1480 ( 4.7A)
 0.82A 5i9yA-2v55A:
19.0		 5i9yA-2v55A:
22.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		9 ILE A 627
ALA A 651
LYS A 653
MET A 674
THR A 699
TYR A 701
GLY A 705
LEU A 753
SER A 763
 None
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.9A)
Q9G  A1898 (-3.5A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
Q9G  A1898 (-3.2A)
 0.60A 5i9yA-2xyuA:
32.4		 5i9yA-2xyuA:
71.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  30
ALA A  51
LYS A  53
GLY A 113
LEU A 160
SER A 170
 B49  A1294 (-3.9A)
B49  A1294 (-3.2A)
None
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
B49  A1294 ( 4.9A)
 0.67A 5i9yA-2y7jA:
24.1		 5i9yA-2y7jA:
22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 273
LYS A 275
GLU A 290
MET A 294
THR A 319
GLY A 325
LEU A 374
 None
 0.60A 5i9yA-2zv7A:
27.4		 5i9yA-2zv7A:
40.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 515
LYS A 517
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
 M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.58A 5i9yA-3b2tA:
27.4		 5i9yA-3b2tA:
35.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ILE A 201
ALA A 220
LYS A 222
GLU A 236
MET A 240
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.86A 5i9yA-3d7uA:
26.5		 5i9yA-3d7uA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ILE A 201
ALA A 220
LYS A 222
THR A 266
TYR A 268
GLY A 272
LEU A 321
SER A 331
 None
 0.64A 5i9yA-3d7uA:
26.5		 5i9yA-3d7uA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ILE A 639
ALA A 663
LYS A 665
GLU A 682
MET A 686
GLY A 717
LEU A 765
 IHZ  A1001 ( 4.8A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.58A 5i9yA-3dkoA:
36.5		 5i9yA-3dkoA:
63.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		8 ILE A 209
ALA A 228
LYS A 230
GLU A 243
TYR A 281
GLY A 285
LEU A 340
SER A 350
 ADP  A 900 (-4.6A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 ( 4.7A)
None
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
None
 0.65A 5i9yA-3g2fA:
15.1		 5i9yA-3g2fA:
28.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ALA A 665
LYS A 667
MET A 688
THR A 713
TYR A 715
GLY A 719
LEU A 767
 None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.65A 5i9yA-3kulA:
35.2		 5i9yA-3kulA:
59.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ALA A 665
LYS A 667
THR A 713
TYR A 715
GLY A 719
LEU A 767
SER A 777
 None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
None
 0.65A 5i9yA-3kulA:
35.2		 5i9yA-3kulA:
59.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		7 ILE A 210
ALA A 229
GLU A 244
THR A 279
TYR A 281
GLY A 285
LEU A 339
 LDN  A   1 (-4.1A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.56A 5i9yA-3mdyA:
25.4		 5i9yA-3mdyA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 227
LYS A 229
GLU A 242
THR A 277
TYR A 279
GLY A 283
LEU A 337
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
 0.70A 5i9yA-3my0A:
25.4		 5i9yA-3my0A:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 109
LYS A 111
MET A 134
TYR A 161
GLY A 165
LEU A 212
 JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
None
None
None
None
 0.71A 5i9yA-3nuuA:
23.7		 5i9yA-3nuuA:
24.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 ILE A 557
ALA A 576
LYS A 578
MET A 600
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-4.1A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.71A 5i9yA-3ppzA:
28.8		 5i9yA-3ppzA:
31.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 217
LYS A 219
GLU A 232
THR A 267
GLY A 273
LEU A 329
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
 0.60A 5i9yA-3q4tA:
24.4		 5i9yA-3q4tA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  82
ALA A 103
LYS A 105
GLU A 124
TYR A 155
LEU A 207
 None
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.0A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.2A)
 0.76A 5i9yA-3qfvA:
19.1		 5i9yA-3qfvA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LYS A 368
GLU A 384
MET A 388
THR A 413
TYR A 415
GLY A 419
LEU A 467
 STU  A   1 (-3.1A)
STU  A   1 (-3.7A)
None
STU  A   1 (-3.9A)
STU  A   1 (-4.7A)
STU  A   1 (-3.6A)
STU  A   1 (-4.6A)
 0.75A 5i9yA-3s95A:
19.1		 5i9yA-3s95A:
29.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 443
LYS A 445
THR A 489
TYR A 491
GLY A 495
LEU A 543
SER A 553
 PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
PP2  A   1 (-3.5A)
 0.74A 5i9yA-3sxsA:
31.4		 5i9yA-3sxsA:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 443
MET A 464
THR A 489
TYR A 491
GLY A 495
LEU A 543
SER A 553
 PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
PP2  A   1 (-3.5A)
 0.54A 5i9yA-3sxsA:
31.4		 5i9yA-3sxsA:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ILE A 625
ALA A 649
LYS A 651
GLU A 668
MET A 672
THR A 697
GLY A 703
LEU A 751
SER A 761
 None
 0.67A 5i9yA-3zfxA:
37.9		 5i9yA-3zfxA:
69.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  10
ALA A  31
LYS A  33
GLU A  51
TYR A  82
LEU A 133
 D15  A 500 (-4.2A)
D15  A 500 (-3.4A)
D15  A 500 ( 4.1A)
None
D15  A 500 (-4.8A)
D15  A 500 (-4.5A)
 0.76A 5i9yA-4aguA:
24.2		 5i9yA-4aguA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 ILE A  83
ALA A 104
LYS A 106
TYR A 156
GLY A 160
LEU A 208
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1420 (-4.9A)
None
EDO  A1420 ( 4.8A)
 0.69A 5i9yA-4aw2A:
20.0		 5i9yA-4aw2A:
24.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ILE A  97
ALA A 121
LYS A 123
GLU A 140
MET A 144
THR A 169
GLY A 175
LEU A 223
SER A 233
 30K  A1365 (-4.5A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 ( 3.7A)
 0.67A 5i9yA-4aw5A:
32.1		 5i9yA-4aw5A:
66.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 ALA A 233
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
 TAK  A1507 (-3.3A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.49A 5i9yA-4c02A:
25.3		 5i9yA-4c02A:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 ALA A 233
LYS A 235
THR A 283
TYR A 285
GLY A 289
LEU A 343
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.49A 5i9yA-4c02A:
25.3		 5i9yA-4c02A:
27.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 653
LYS A 655
GLU A 672
MET A 676
THR A 701
TYR A 703
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.0A)
 0.77A 5i9yA-4ckrA:
30.8		 5i9yA-4ckrA:
37.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 ILE A 567
ALA A 588
LYS A 590
GLU A 607
GLY A 642
LEU A 690
SER A 700
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
 0.59A 5i9yA-4e93A:
34.4		 5i9yA-4e93A:
34.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 400
LYS A 402
GLU A 420
MET A 424
GLY A 454
LEU A 501
SER A 511
 0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.2A)
 0.65A 5i9yA-4f4pA:
31.7		 5i9yA-4f4pA:
36.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		7 ILE A 327
ALA A 348
LYS A 350
MET A 370
GLY A 401
LEU A 447
SER A 457
 None
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
None
None
ANP  A1001 (-4.7A)
ANP  A1001 ( 4.4A)
 0.84A 5i9yA-4fieA:
22.4		 5i9yA-4fieA:
22.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 506
LYS A 508
GLU A 525
MET A 529
TYR A 557
GLY A 561
LEU A 624
 ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
None
None
ACP  A 801 ( 4.6A)
ACP  A 801 (-4.4A)
 0.79A 5i9yA-4k33A:
27.1		 5i9yA-4k33A:
33.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 413
ALA A 434
LYS A 436
MET A 456
GLY A 487
LEU A 533
SER A 543
 B49  A 701 (-4.2A)
B49  A 701 (-3.2A)
None
None
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
B49  A 701 (-3.0A)
 0.74A 5i9yA-4ks8A:
23.8		 5i9yA-4ks8A:
28.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 293
LYS A 295
GLU A 310
MET A 314
TYR A 340
GLY A 344
LEU A 393
 VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.60A 5i9yA-4lggA:
30.8		 5i9yA-4lggA:
40.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		9 ILE A 619
ALA A 644
GLU A 663
MET A 667
THR A 692
TYR A 694
GLY A 698
LEU A 746
SER A 756
 None
 0.97A 5i9yA-4p2kA:
35.7		 5i9yA-4p2kA:
94.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		9 ILE A 619
ALA A 644
LYS A 646
GLU A 663
MET A 667
TYR A 694
GLY A 698
LEU A 746
SER A 756
 None
 1.16A 5i9yA-4p2kA:
35.7		 5i9yA-4p2kA:
94.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		9 ILE A 619
ALA A 644
LYS A 646
MET A 667
TYR A 694
GLY A 698
GLU A 706
LEU A 746
SER A 756
 None
 1.17A 5i9yA-4p2kA:
35.7		 5i9yA-4p2kA:
94.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		9 ILE A 619
ALA A 644
MET A 667
THR A 692
TYR A 694
GLY A 698
GLU A 706
LEU A 746
SER A 756
 None
 0.93A 5i9yA-4p2kA:
35.7		 5i9yA-4p2kA:
94.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		8 ALA A  35
LYS A  37
GLU A  52
MET A  56
THR A  81
TYR A  83
GLY A  87
LEU A 136
 ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.53A 5i9yA-4ueuA:
32.9		 5i9yA-4ueuA:
44.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		6 ALA A 348
LYS A 350
MET A 370
GLY A 401
LEU A 447
SER A 457
 ATP  A 601 ( 3.7A)
ATP  A 601 (-2.8A)
None
None
None
ATP  A 601 ( 4.6A)
 0.67A 5i9yA-4xbrA:
18.5		 5i9yA-4xbrA:
24.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 7 ALA B 288
LYS B 290
MET B 309
THR B 334
GLY B 340
GLU B 348
LEU B 389
 1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 (-3.7A)
1N1  B 601 (-3.3A)
1N1  B 601 (-3.5A)
None
1N1  B 601 (-4.3A)
 0.69A 5i9yA-4xeyB:
25.2		 5i9yA-4xeyB:
31.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 428
THR A 474
TYR A 476
GLY A 480
LEU A 528
SER A 538
 None
 0.77A 5i9yA-4xi2A:
27.0		 5i9yA-4xi2A:
29.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		8 ALA A 428
LYS A 430
THR A 474
TYR A 476
GLY A 480
GLU A 488
LEU A 528
SER A 538
 746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
CA  A 703 ( 4.5A)
746  A 702 (-4.4A)
746  A 702 ( 3.8A)
 0.93A 5i9yA-4y93A:
31.1		 5i9yA-4y93A:
26.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A 469
ALA A 488
LYS A 490
GLU A 509
THR A 539
TYR A 541
GLU A 553
 4CV  A 801 (-4.3A)
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
4CV  A 801 (-2.8A)
4CV  A 801 (-3.9A)
None
 0.98A 5i9yA-4yffA:
19.7		 5i9yA-4yffA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A 469
ALA A 488
LYS A 490
THR A 539
TYR A 541
GLU A 553
LEU A 595
 4CV  A 801 (-4.3A)
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
4CV  A 801 (-2.8A)
4CV  A 801 (-3.9A)
None
4CV  A 801 (-4.4A)
 1.09A 5i9yA-4yffA:
19.7		 5i9yA-4yffA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A 469
ALA A 488
THR A 539
TYR A 541
GLY A 545
GLU A 553
LEU A 595
 4CV  A 801 (-4.3A)
4CV  A 801 (-3.5A)
4CV  A 801 (-2.8A)
4CV  A 801 (-3.9A)
4CV  A 801 ( 4.0A)
None
4CV  A 801 (-4.4A)
 1.34A 5i9yA-4yffA:
19.7		 5i9yA-4yffA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 512
LYS A 514
GLU A 531
TYR A 563
GLY A 567
LEU A 630
 38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.77A 5i9yA-5a46A:
32.8		 5i9yA-5a46A:
31.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  22
ALA A  44
LYS A  46
GLU A  63
TYR A  94
GLY A  98
LEU A 145
 51W  A 401 (-3.9A)
51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
None
51W  A 401 ( 3.4A)
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
 0.68A 5i9yA-5ci7A:
23.1		 5i9yA-5ci7A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 275
LYS A 277
GLU A 290
THR A 325
GLY A 331
LEU A 386
 STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
STU  A 601 (-3.5A)
STU  A 601 (-3.9A)
 0.66A 5i9yA-5e8yA:
19.5		 5i9yA-5e8yA:
29.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 928
LYS A 930
GLU A 947
TYR A 980
GLY A 984
LEU A1030
 5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.63A 5i9yA-5f1zA:
22.3		 5i9yA-5f1zA:
31.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 756
LYS A 758
GLU A 775
TYR A 806
GLU A 818
LEU A 881
SER A 891
 PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
PTR  A 809 ( 4.7A)
PP1  A2012 (-4.6A)
PP1  A2012 (-3.1A)
 0.76A 5i9yA-5fm2A:
25.1		 5i9yA-5fm2A:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 756
LYS A 758
GLU A 775
TYR A 806
GLY A 810
LEU A 881
SER A 891
 PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
PP1  A2012 (-3.1A)
 0.60A 5i9yA-5fm2A:
25.1		 5i9yA-5fm2A:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 625
LYS A 627
GLU A 644
MET A 648
THR A 674
TYR A 676
LEU A 825
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.86A 5i9yA-5grnA:
25.3		 5i9yA-5grnA:
31.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 625
LYS A 627
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.43A 5i9yA-5grnA:
25.3		 5i9yA-5grnA:
31.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 105
THR A 148
TYR A 150
GLY A 154
GLU A 161
LEU A 215
 None
 0.71A 5i9yA-5gz8A:
19.4		 5i9yA-5gz8A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gza PROTEIN O-MANNOSE
KINASE

(Danio rerio) 		PF07714
(Pkinase_Tyr) 		6 ILE A  85
ALA A 104
THR A 147
TYR A 149
GLY A 153
LEU A 214
 ADP  A 401 ( 4.9A)
ADP  A 401 (-3.2A)
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.1A)
ADP  A 401 (-4.4A)
 0.42A 5i9yA-5gzaA:
13.1		 5i9yA-5gzaA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  22
ALA A  43
LYS A  45
MET A  65
GLY A  96
LEU A 143
 6G2  A 901 (-3.8A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.76A 5i9yA-5j5tA:
22.5		 5i9yA-5j5tA:
23.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 743
LYS A 745
GLU A 762
MET A 766
GLY A 796
GLU A 804
LEU A 844
 6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.5A)
None
6HJ  A1101 ( 4.8A)
 0.71A 5i9yA-5j9zA:
32.7		 5i9yA-5j9zA:
35.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 276
ALA A 297
LYS A 299
MET A 319
TYR A 346
GLY A 350
LEU A 396
 IPW  A 601 (-4.0A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.1A)
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.66A 5i9yA-5kbrA:
22.1		 5i9yA-5kbrA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 228
LYS A 230
GLU A 250
MET A 254
TYR A 285
GLY A 289
LEU A 338
 6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
None
6UY  A 501 ( 4.8A)
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
 0.61A 5i9yA-5ko1A:
28.6		 5i9yA-5ko1A:
29.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 639
ALA A 663
MET A 686
THR A 711
LEU A 765
SER A 775
 6P6  A1001 (-4.0A)
6P6  A1001 (-3.3A)
6P6  A1001 ( 4.2A)
6P6  A1001 (-3.5A)
6P6  A1001 (-4.5A)
6P6  A1001 ( 3.7A)
 0.64A 5i9yA-5l6oA:
35.7		 5i9yA-5l6oA:
68.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 ILE A 889
ALA A 909
LYS A 911
GLU A 927
GLY A 962
LEU A1016
SER A1026
 None
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 ( 4.7A)
 0.74A 5i9yA-5lpyA:
23.8		 5i9yA-5lpyA:
29.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ILE A 889
ALA A 909
LYS A 911
GLU A 927
GLY A 962
LEU A1016
 ADP  A1200 (-4.7A)
ADP  A1200 (-3.5A)
ADP  A1200 ( 4.3A)
None
ADP  A1200 ( 4.0A)
ADP  A1200 (-4.7A)
 0.73A 5i9yA-5lpzA:
23.7		 5i9yA-5lpzA:
29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ILE A 889
ALA A 909
LYS A 911
GLY A 962
LEU A1016
SER A1026
 ADP  A1200 (-4.7A)
ADP  A1200 (-3.5A)
ADP  A1200 ( 4.3A)
ADP  A1200 ( 4.0A)
ADP  A1200 (-4.7A)
ADP  A1200 ( 4.6A)
 0.66A 5i9yA-5lpzA:
23.7		 5i9yA-5lpzA:
29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 ILE A  98
ALA A 119
LYS A 121
GLU A 140
MET A 144
TYR A 171
GLY A 175
LEU A 221
 None
 0.71A 5i9yA-5u7qA:
20.0		 5i9yA-5u7qA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		no annotation 6 ILE A 327
ALA A 348
LYS A 350
GLY A 401
LEU A 447
SER A 457
 M77  A 601 ( 4.8A)
M77  A 601 ( 3.5A)
M77  A 601 ( 4.7A)
M77  A 601 ( 4.8A)
M77  A 601 (-4.6A)
M77  A 601 (-3.2A)
 0.73A 5i9yA-5vefA:
22.6		 5i9yA-5vefA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 7 ALA A  45
LYS A  47
THR A  95
TYR A  97
GLY A 101
GLU A 112
LEU A 153
 9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
None
9WS  A 401 (-4.6A)
 0.98A 5i9yA-5w5jA:
14.9		 5i9yA-5w5jA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 6 ALA A  49
MET A  73
TYR A  98
GLY A 102
LEU A 150
SER A 160
 VX6  A 402 (-3.2A)
None
VX6  A 402 (-4.3A)
VX6  A 402 (-3.5A)
VX6  A 402 (-4.4A)
VX6  A 402 (-3.3A)
 0.38A 5i9yA-5wnmA:
29.0		 5i9yA-5wnmA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 ALA A 917
LYS A 919
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.67A 5i9yA-5wnoA:
28.0		 5i9yA-5wnoA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana) 		no annotation 6 ILE A  75
ALA A  95
LYS A  97
TYR A 143
GLY A 147
LEU A 206
 ANP  A1000 (-4.2A)
ANP  A1000 (-3.2A)
ANP  A1000 (-2.8A)
ANP  A1000 (-4.3A)
None
ANP  A1000 (-4.5A)
 0.66A 5i9yA-5xd6A:
23.5		 5i9yA-5xd6A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 6 ILE A 733
ALA A 754
LYS A 756
GLU A 774
TYR A 815
LEU A 866
 CJM  A1102 (-3.4A)
CJM  A1102 (-3.1A)
None
None
CJM  A1102 (-4.1A)
CJM  A1102 (-4.4A)
 0.70A 5i9yA-6b3eA:
23.4		 5i9yA-6b3eA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 6 ILE A 171
ALA A 192
LYS A 194
GLU A 236
GLY A 273
LEU A 319
 BI9  A 501 (-4.0A)
BI9  A 501 (-3.3A)
NH4  A 506 ( 4.4A)
NH4  A 506 (-3.0A)
BI9  A 501 (-3.3A)
BI9  A 501 (-4.7A)
 0.62A 5i9yA-6bqlA:
23.1		 5i9yA-6bqlA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 6 ALA A 756
GLU A 775
TYR A 806
GLY A 810
LEU A 881
SER A 891
 ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.1A)
ADN  A1104 ( 3.8A)
ADN  A1104 (-4.3A)
ADN  A1104 ( 4.8A)
 0.37A 5i9yA-6fekA:
26.6		 5i9yA-6fekA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b6r PROTEIN
(N5-CARBOXYAMINOIMID
AZOLE RIBONUCLEOTIDE
SYNTHETASE)

(Escherichia
coli) 		PF02222
(ATP-grasp) 		3 ILE A 213
ILE A  76
MET A 225
 None
 0.50A 5i9yA-1b6rA:
undetectable		 5i9yA-1b6rA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bx0 PROTEIN
(FERREDOXIN:NADP+
OXIDOREDUCTASE)

(Spinacia
oleracea) 		PF00175
(NAD_binding_1) 		3 ILE A 166
ILE A 281
MET A 261
 None
 0.69A 5i9yA-1bx0A:
undetectable		 5i9yA-1bx0A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cle CHOLESTEROL ESTERASE

([Candida]
cylindracea) 		PF00135
(COesterase) 		3 ILE A 466
ILE A 238
MET A 503
 None
 0.63A 5i9yA-1cleA:
undetectable		 5i9yA-1cleA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		3 ILE A 466
ILE A 238
MET A 503
 None
 0.67A 5i9yA-1crlA:
undetectable		 5i9yA-1crlA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE

(Methanopyrus
kandleri) 		PF00296
(Bac_luciferase) 		3 ILE A 131
ILE A  93
MET A 182
 None
 0.65A 5i9yA-1ezwA:
undetectable		 5i9yA-1ezwA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gm5 RECG

(Thermotoga
maritima) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF17190
(RecG_N)
PF17191
(RecG_wedge) 		3 ILE A 649
ILE A 663
MET A 619
 None
 0.52A 5i9yA-1gm5A:
undetectable		 5i9yA-1gm5A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		3 ILE A 466
ILE A 238
MET A 503
 None
 0.67A 5i9yA-1gz7A:
undetectable		 5i9yA-1gz7A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR

(Equus caballus) 		PF00079
(Serpin) 		3 ILE A 333
ILE A 169
MET A 177
 None
 0.60A 5i9yA-1hleA:
undetectable		 5i9yA-1hleA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hv2 ELONGIN C

(Saccharomyces
cerevisiae) 		PF03931
(Skp1_POZ) 		3 ILE A  44
ILE A  18
MET A  32
 None
 0.66A 5i9yA-1hv2A:
undetectable		 5i9yA-1hv2A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays) 		PF00232
(Glyco_hydro_1) 		3 ILE A 397
ILE A 440
MET A 388
 None
 0.68A 5i9yA-1hxjA:
undetectable		 5i9yA-1hxjA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji0 ABC TRANSPORTER

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		3 ILE A 149
ILE A  91
MET A 162
 None
 0.71A 5i9yA-1ji0A:
undetectable		 5i9yA-1ji0A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqg CARBOXYPEPTIDASE A

(Helicoverpa
armigera) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		3 ILE A 297
ILE A 202
MET A  64
 None
 0.66A 5i9yA-1jqgA:
undetectable		 5i9yA-1jqgA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p8r ARGINASE 1

(Rattus
norvegicus) 		PF00491
(Arginase) 		3 ILE A 177
ILE A 174
MET A 212
 None
 0.64A 5i9yA-1p8rA:
undetectable		 5i9yA-1p8rA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl8 HUMAN SORBITOL
DEHYDROGENASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ILE A  93
ILE A 154
MET A  38
 None
 0.70A 5i9yA-1pl8A:
undetectable		 5i9yA-1pl8A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF04166
(PdxA) 		3 ILE A 185
ILE A 226
MET A 238
 None
 0.67A 5i9yA-1ps6A:
undetectable		 5i9yA-1ps6A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb7 TRNA PSEUDOURIDINE
SYNTHASE D

(Escherichia
coli) 		PF01142
(TruD) 		3 ILE A  44
ILE A  68
MET A  98
 None
 0.69A 5i9yA-1sb7A:
undetectable		 5i9yA-1sb7A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1seh DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Escherichia
coli) 		PF00692
(dUTPase) 		3 ILE A  99
ILE A  80
MET A  68
 None
None
UMP  A 777 (-4.4A)
 0.65A 5i9yA-1sehA:
undetectable		 5i9yA-1sehA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF14519
(Macro_2) 		3 ILE A  19
ILE A 185
MET A 217
 None
 0.71A 5i9yA-1txzA:
undetectable		 5i9yA-1txzA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE

(Bacillus
subtilis) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		3 ILE X  21
ILE X  50
MET X  84
 None
 0.70A 5i9yA-1u8xX:
undetectable		 5i9yA-1u8xX:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc8 LYSINE BIOSYNTHESIS
ENZYME

(Thermus
thermophilus) 		PF08443
(RimK) 		3 ILE A 271
ILE A   4
MET A 254
 None
 0.62A 5i9yA-1uc8A:
undetectable		 5i9yA-1uc8A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 ILE A 390
ILE A 362
MET A  90
 None
 0.68A 5i9yA-1wl4A:
undetectable		 5i9yA-1wl4A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0y FRV OPERON PROTEIN
FRVX

(Pyrococcus
horikoshii) 		PF05343
(Peptidase_M42) 		3 ILE A  65
ILE A  37
MET A 341
 None
 0.63A 5i9yA-1y0yA:
undetectable		 5i9yA-1y0yA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb2 HYPOTHETICAL PROTEIN
TA0852

(Thermoplasma
acidophilum) 		PF08704
(GCD14) 		3 ILE A 164
ILE A 167
MET A 104
 None
 0.67A 5i9yA-1yb2A:
undetectable		 5i9yA-1yb2A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt5 INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Thermotoga
maritima) 		PF01513
(NAD_kinase) 		3 ILE A 224
ILE A 180
MET A 211
 None
 0.71A 5i9yA-1yt5A:
undetectable		 5i9yA-1yt5A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywk 4-DEOXY-L-THREO-5-HE
XOSULOSE-URONATE
KETOL-ISOMERASE 1

(Enterococcus
faecalis) 		PF04962
(KduI) 		3 ILE A1079
ILE A1142
MET A1177
 None
 0.65A 5i9yA-1ywkA:
undetectable		 5i9yA-1ywkA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbt PEPTIDE CHAIN
RELEASE FACTOR 1

(Streptococcus
mutans) 		PF00472
(RF-1)
PF03462
(PCRF) 		3 ILE A 274
ILE A 254
MET A 258
 None
 0.70A 5i9yA-1zbtA:
undetectable		 5i9yA-1zbtA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		3 ILE A 126
ILE A 146
MET A  61
 None
 0.54A 5i9yA-1zltA:
21.0		 5i9yA-1zltA:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7d UVRABC SYSTEM
PROTEIN B

(Bacillus
subtilis) 		PF00271
(Helicase_C)
PF02151
(UVR)
PF04851
(ResIII)
PF12344
(UvrB) 		3 ILE A 431
ILE A 468
MET A 457
 None
 0.64A 5i9yA-2d7dA:
undetectable		 5i9yA-2d7dA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 ILE A 248
ILE A 166
MET A 156
 None
 0.66A 5i9yA-2ep5A:
undetectable		 5i9yA-2ep5A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		3 ILE A  72
ILE A  91
MET A  96
 None
 0.53A 5i9yA-2f9gA:
16.9		 5i9yA-2f9gA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE

(Dictyostelium
discoideum) 		PF01979
(Amidohydro_1) 		3 ILE A 134
ILE A 102
MET A 145
 KCX  A 158 ( 4.2A)
None
None
 0.69A 5i9yA-2ftwA:
undetectable		 5i9yA-2ftwA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grk EVM001

(Ectromelia
virus) 		PF02250
(Orthopox_35kD) 		3 ILE A  28
ILE A 169
MET A  79
 None
 0.60A 5i9yA-2grkA:
undetectable		 5i9yA-2grkA:
20.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		3 ILE A 691
ILE A 705
MET A 710
 None
 0.19A 5i9yA-2henA:
37.5		 5i9yA-2henA:
67.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iut DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa) 		PF01580
(FtsK_SpoIIIE) 		3 ILE A 627
ILE A 495
MET A 479
 None
 0.67A 5i9yA-2iutA:
undetectable		 5i9yA-2iutA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfq GLUTAMATE RACEMASE

(Staphylococcus
aureus) 		PF01177
(Asp_Glu_race) 		3 ILE A 248
ILE A  36
MET A 153
 None
 0.70A 5i9yA-2jfqA:
undetectable		 5i9yA-2jfqA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kok ARSENATE REDUCTASE

(Brucella
abortus) 		PF03960
(ArsC) 		3 ILE A   9
ILE A  30
MET A  18
 None
 0.59A 5i9yA-2kokA:
undetectable		 5i9yA-2kokA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF00977
(His_biosynth) 		3 ILE A  33
ILE A  80
MET A  67
 None
 0.68A 5i9yA-2lleA:
undetectable		 5i9yA-2lleA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF00977
(His_biosynth) 		3 ILE A  41
ILE A  56
MET A  67
 None
 0.69A 5i9yA-2lleA:
undetectable		 5i9yA-2lleA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mnj PROTEIN INTERACTING
WITH HSP90 1

(Saccharomyces
cerevisiae) 		no annotation 3 ILE B  83
ILE B  98
MET B  38
 None
 0.63A 5i9yA-2mnjB:
undetectable		 5i9yA-2mnjB:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0y GCN5-RELATED
N-ACETYLTRANSFERASE

(Cupriavidus
pinatubonensis) 		PF00583
(Acetyltransf_1) 		3 ILE A  89
ILE A 120
MET A 108
 UNL  A 156 ( 4.8A)
None
None
 0.65A 5i9yA-2q0yA:
undetectable		 5i9yA-2q0yA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qh9 UPF0215 PROTEIN
AF_1433

(Archaeoglobus
fulgidus) 		PF01949
(DUF99) 		3 ILE A   9
ILE A  80
MET A  52
 None
 0.68A 5i9yA-2qh9A:
undetectable		 5i9yA-2qh9A:
23.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ILE A 683
ILE A 697
MET A 702
 None
None
PTR  A 701 ( 3.5A)
 0.39A 5i9yA-2qobA:
29.2		 5i9yA-2qobA:
68.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		3 ILE A 737
ILE A 751
MET A 756
 None
 0.20A 5i9yA-2r2pA:
36.7		 5i9yA-2r2pA:
68.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rij PUTATIVE
2,3,4,5-TETRAHYDROPY
RIDINE-2-CARBOXYLATE
N-
SUCCINYLTRANSFERASE

(Campylobacter
jejuni) 		PF14602
(Hexapep_2)
PF14789
(THDPS_M)
PF14790
(THDPS_N) 		3 ILE A 318
ILE A 313
MET A 370
 None
 0.67A 5i9yA-2rijA:
undetectable		 5i9yA-2rijA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 ILE B 184
ILE B 323
MET B 166
 None
 0.50A 5i9yA-2v4jB:
2.4		 5i9yA-2v4jB:
23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		3 ILE A 683
ILE A 697
MET A 702
 Q9G  A1898 ( 4.9A)
Q9G  A1898 ( 4.6A)
None
 0.35A 5i9yA-2xyuA:
32.4		 5i9yA-2xyuA:
71.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID

(Neisseria
gonorrhoeae) 		PF00497
(SBP_bac_3) 		3 ILE A  77
ILE A 232
MET A 254
 None
 0.65A 5i9yA-2yjpA:
undetectable		 5i9yA-2yjpA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1

(Aeropyrum
pernix) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		3 ILE A  51
ILE A 463
MET A 332
 None
 0.65A 5i9yA-3a31A:
undetectable		 5i9yA-3a31A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7c UNCHARACTERIZED
PROTEIN

(Shewanella
oneidensis) 		PF14534
(DUF4440) 		3 ILE A   6
ILE A 114
MET A  76
 None
 0.57A 5i9yA-3b7cA:
2.2		 5i9yA-3b7cA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdr YCF58 PROTEIN

(Synechococcus
elongatus) 		PF09367
(CpeS) 		3 ILE A   7
ILE A  93
MET A 122
 None
 0.70A 5i9yA-3bdrA:
undetectable		 5i9yA-3bdrA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2g SYS-1 PROTEIN

(Caenorhabditis
elegans) 		no annotation 3 ILE A 371
ILE A 376
MET A 328
 None
 0.67A 5i9yA-3c2gA:
undetectable		 5i9yA-3c2gA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cah AGGLUTININ II

(Sambucus nigra) 		PF00652
(Ricin_B_lectin) 		3 ILE A 238
ILE A 197
MET A 155
 None
 0.68A 5i9yA-3cahA:
undetectable		 5i9yA-3cahA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA

(Chlorobaculum
tepidum) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		3 ILE A  54
ILE A  46
MET A 424
 None
 0.68A 5i9yA-3cp8A:
undetectable		 5i9yA-3cp8A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8u PURR TRANSCRIPTIONAL
REGULATOR

(Vibrio
parahaemolyticus) 		PF13377
(Peripla_BP_3) 		3 ILE A 261
ILE A 280
MET A 288
 None
 0.70A 5i9yA-3d8uA:
undetectable		 5i9yA-3d8uA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd5 SELENIDE, WATER
DIKINASE 1

(Homo sapiens) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 ILE A 170
ILE A  92
MET A 141
 None
 0.65A 5i9yA-3fd5A:
undetectable		 5i9yA-3fd5A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn9 PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		3 ILE A 346
ILE A 376
MET A 558
 None
 0.69A 5i9yA-3fn9A:
undetectable		 5i9yA-3fn9A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fya REGULATORY PROTEIN

(Enterobacter
sp. RFL1396) 		PF01381
(HTH_3) 		3 ILE A  16
ILE A  56
MET A  70
 None
 0.69A 5i9yA-3fyaA:
undetectable		 5i9yA-3fyaA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gmf PROTEIN-DISULFIDE
ISOMERASE

(Novosphingobium
aromaticivorans) 		PF13462
(Thioredoxin_4) 		3 ILE A 111
ILE A 161
MET A 171
 None
 0.70A 5i9yA-3gmfA:
undetectable		 5i9yA-3gmfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpg NON-STRUCTURAL
PROTEIN 3

(Chikungunya
virus) 		PF01661
(Macro) 		3 ILE A 106
ILE A 152
MET A 132
 None
 0.71A 5i9yA-3gpgA:
undetectable		 5i9yA-3gpgA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4m PROTEASOME-ACTIVATIN
G NUCLEOTIDASE

(Methanocaldococcus
jannaschii) 		PF00004
(AAA) 		3 ILE A 368
ILE A 411
MET A 401
 None
 0.54A 5i9yA-3h4mA:
undetectable		 5i9yA-3h4mA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5t AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00202
(Aminotran_3) 		3 ILE A 437
ILE A 426
MET A 355
 None
 0.58A 5i9yA-3i5tA:
undetectable		 5i9yA-3i5tA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		3 ILE A 286
ILE A 299
MET A 304
 None
 0.48A 5i9yA-3i6uA:
21.3		 5i9yA-3i6uA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		3 ILE A 127
ILE A 181
MET A 168
 ILE  A 127 ( 0.7A)
ILE  A 181 ( 0.7A)
PHE  A 124 ( 3.8A)
 0.67A 5i9yA-3iccA:
undetectable		 5i9yA-3iccA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5z FEM-3 MRNA-BINDING
FACTOR 2

(Caenorhabditis
elegans) 		PF00806
(PUF) 		3 ILE A 421
ILE A 435
MET A 398
 None
 0.70A 5i9yA-3k5zA:
undetectable		 5i9yA-3k5zA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmi PUTATIVE MEMBRANE
PROTEIN COG4129

(Clostridioides
difficile) 		PF11728
(ArAE_1_C) 		3 ILE A 196
ILE A 203
MET A 218
 None
 0.69A 5i9yA-3kmiA:
undetectable		 5i9yA-3kmiA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krb ALDOSE REDUCTASE

(Giardia
intestinalis) 		PF00248
(Aldo_ket_red) 		3 ILE A  53
ILE A  68
MET A  28
 None
 0.62A 5i9yA-3krbA:
undetectable		 5i9yA-3krbA:
22.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		3 ILE A 697
ILE A 711
MET A 716
 None
 0.36A 5i9yA-3kulA:
35.2		 5i9yA-3kulA:
59.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A

(Shewanella
denitrificans) 		PF00246
(Peptidase_M14) 		3 ILE A  23
ILE A  12
MET A   1
 None
 0.63A 5i9yA-3l2nA:
undetectable		 5i9yA-3l2nA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Staphylococcus
aureus) 		PF00724
(Oxidored_FMN) 		3 ILE A 299
ILE A 224
MET A 254
 None
 0.58A 5i9yA-3l5aA:
undetectable		 5i9yA-3l5aA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m66 MTERF
DOMAIN-CONTAINING
PROTEIN 1,
MITOCHONDRIAL

(Homo sapiens) 		PF02536
(mTERF) 		3 ILE A 215
ILE A 169
MET A 191
 None
 0.67A 5i9yA-3m66A:
undetectable		 5i9yA-3m66A:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Archaeoglobus
fulgidus) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 ILE B 173
ILE B 306
MET B 155
 None
 0.56A 5i9yA-3mm5B:
2.7		 5i9yA-3mm5B:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2x UNCHARACTERIZED
PROTEIN YAGE

(Escherichia
coli) 		PF00701
(DHDPS) 		3 ILE A 173
ILE A 219
MET A 186
 MCL  A 174 ( 3.6A)
MCL  A 174 ( 3.7A)
None
 0.71A 5i9yA-3n2xA:
undetectable		 5i9yA-3n2xA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogk CORONATINE-INSENSITI
VE PROTEIN 1

(Arabidopsis
thaliana) 		no annotation 3 ILE B 505
ILE B 542
MET B 495
 None
 0.62A 5i9yA-3ogkB:
undetectable		 5i9yA-3ogkB:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 ILE A 472
ILE A 416
MET A 332
 None
 0.62A 5i9yA-3ogrA:
undetectable		 5i9yA-3ogrA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4

(Saccharomyces
cerevisiae) 		PF11701
(UNC45-central) 		3 ILE A 335
ILE A 375
MET A 365
 None
 0.62A 5i9yA-3opbA:
undetectable		 5i9yA-3opbA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r13 DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Thermotoga
maritima) 		PF01791
(DeoC) 		3 ILE A 153
ILE A 169
MET A 197
 None
 0.70A 5i9yA-3r13A:
undetectable		 5i9yA-3r13A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL

(Homo sapiens) 		PF00271
(Helicase_C)
PF12513
(SUV3_C) 		3 ILE A 370
ILE A 435
MET A 486
 None
 0.72A 5i9yA-3rc3A:
undetectable		 5i9yA-3rc3A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh9 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(NAD(P)(+))

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		3 ILE A   2
ILE A 189
MET A  95
 None
 0.70A 5i9yA-3rh9A:
undetectable		 5i9yA-3rh9A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 3 ILE N 161
ILE K  75
MET K  31
 None
 0.68A 5i9yA-3rkoN:
undetectable		 5i9yA-3rkoN:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7y YOP PROTEINS
TRANSLOCATION
PROTEIN U

(Chlamydia
trachomatis) 		PF01312
(Bac_export_2) 		3 ILE A 336
ILE A 325
MET A 306
 None
 0.70A 5i9yA-3t7yA:
undetectable		 5i9yA-3t7yA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE

(Vibrio cholerae) 		PF00857
(Isochorismatase) 		3 ILE A  58
ILE A 142
MET A  36
 None
 0.67A 5i9yA-3tb4A:
undetectable		 5i9yA-3tb4A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS

(Pyrococcus
furiosus) 		PF08489
(DUF1743) 		3 ILE A  69
ILE A  32
MET A   1
 None
 0.71A 5i9yA-3u02A:
undetectable		 5i9yA-3u02A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v39 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		3 ILE A  71
ILE A 402
MET A 310
 None
 0.71A 5i9yA-3v39A:
undetectable		 5i9yA-3v39A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w25 GLYCOSIDE HYDROLASE
FAMILY 10

(Thermoanaerobacterium
saccharolyticum) 		PF00331
(Glyco_hydro_10) 		3 ILE A 218
ILE A 237
MET A 201
 None
 0.65A 5i9yA-3w25A:
undetectable		 5i9yA-3w25A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whi SUBTILISIN E

(Bacillus
subtilis) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		3 ILE A 197
ILE A  73
MET A 214
 None
 0.65A 5i9yA-3whiA:
undetectable		 5i9yA-3whiA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdr ALCOHOL
DEHYDROGENASE DOMAIN
OF THE BIFUNCTIONAL
ACETALDEHYDE
DEHYDROGENASE

(Parageobacillus
thermoglucosidasius) 		PF00465
(Fe-ADH) 		3 ILE A 548
ILE A 485
MET A 540
 None
 0.56A 5i9yA-3zdrA:
undetectable		 5i9yA-3zdrA:
20.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ILE A 681
ILE A 695
MET A 700
 None
 0.40A 5i9yA-3zfxA:
37.9		 5i9yA-3zfxA:
69.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjc GTPASE IMAP FAMILY
MEMBER 7

(Homo sapiens) 		PF04548
(AIG1) 		3 ILE A 115
ILE A  85
MET A 127
 None
 0.67A 5i9yA-3zjcA:
undetectable		 5i9yA-3zjcA:
21.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ILE A 153
ILE A 167
MET A 172
 None
 0.51A 5i9yA-4aw5A:
32.1		 5i9yA-4aw5A:
66.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bj6 RAP1-INTERACTING
FACTOR 2

(Saccharomyces
cerevisiae) 		no annotation 3 ILE A 245
ILE A 138
MET A 195
 None
 0.40A 5i9yA-4bj6A:
undetectable		 5i9yA-4bj6A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bsn EXPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		3 ILE A 501
ILE A 521
MET A 476
 None
 0.55A 5i9yA-4bsnA:
undetectable		 5i9yA-4bsnA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		3 ILE A  55
ILE A  39
MET A  29
 None
 0.71A 5i9yA-4c22A:
undetectable		 5i9yA-4c22A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN

(Helicobacter
pylori) 		no annotation 3 ILE P 449
ILE P 463
MET P 405
 None
 0.64A 5i9yA-4dvyP:
undetectable		 5i9yA-4dvyP:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvz CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN

(Helicobacter
pylori) 		no annotation 3 ILE A 449
ILE A 463
MET A 405
 None
 0.67A 5i9yA-4dvzA:
undetectable		 5i9yA-4dvzA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dz6 NUCLEOSIDE
DIPHOSPHATE KINASE

(Borreliella
burgdorferi) 		PF00334
(NDK) 		3 ILE A  22
ILE A 133
MET A  41
 None
 0.68A 5i9yA-4dz6A:
undetectable		 5i9yA-4dz6A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ell RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A) 		3 ILE A 724
ILE A 753
MET A 708
 None
 0.68A 5i9yA-4ellA:
undetectable		 5i9yA-4ellA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Ochrobactrum
sp. T63) 		PF00561
(Abhydrolase_1) 		3 ILE A  30
ILE A 109
MET A  84
 None
 0.65A 5i9yA-4g8dA:
undetectable		 5i9yA-4g8dA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gis ENOLASE

(Vibrio harveyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ILE A  25
ILE A 100
MET A 369
 None
 0.65A 5i9yA-4gisA:
undetectable		 5i9yA-4gisA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl6 HYPOTHETICAL PROTEIN

([Ruminococcus]
gnavus) 		PF16440
(DUF5037) 		3 ILE A 128
ILE A 142
MET A 107
 None
 0.64A 5i9yA-4gl6A:
undetectable		 5i9yA-4gl6A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Acinetobacter
sp. ADP1) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		3 ILE A 214
ILE A 257
MET A 229
 None
 0.66A 5i9yA-4gtnA:
undetectable		 5i9yA-4gtnA:
22.11