SIMILAR PATTERNS OF AMINO ACIDS FOR 5I9X_A_DB8A1001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 428
ILE A 472
THR A 474
TYR A 476
GLY A 480
GLU A 488
LEU A 528
SER A 538
 None
 1.06A 5i9xA-1k2pA:
28.7		 5i9xA-1k2pA:
39.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 428
LYS A 430
ILE A 472
TYR A 476
GLY A 480
GLU A 488
LEU A 528
SER A 538
 None
 1.11A 5i9xA-1k2pA:
28.7		 5i9xA-1k2pA:
39.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 ILE A 201
ALA A 220
GLU A 236
ILE A 264
THR A 266
GLY A 272
LEU A 321
SER A 331
 None
 0.77A 5i9xA-1k9aA:
31.9		 5i9xA-1k9aA:
27.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 ILE A 201
ALA A 220
ILE A 264
THR A 266
TYR A 268
GLY A 272
LEU A 321
SER A 331
 None
 0.65A 5i9xA-1k9aA:
31.9		 5i9xA-1k9aA:
27.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 ILE A 201
ALA A 220
LYS A 222
GLU A 236
ILE A 264
THR A 266
GLY A 272
LEU A 321
 None
 0.97A 5i9xA-1k9aA:
31.9		 5i9xA-1k9aA:
27.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 ILE A 201
ALA A 220
LYS A 222
ILE A 264
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.77A 5i9xA-1k9aA:
31.9		 5i9xA-1k9aA:
27.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ALA A 288
LYS A 290
ILE A 332
THR A 334
GLY A 340
GLU A 348
LEU A 389
 P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
None
P16  A   2 (-4.4A)
 0.74A 5i9xA-1opkA:
31.6		 5i9xA-1opkA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 ILE A 211
ALA A 230
GLU A 245
TYR A 282
GLY A 286
LEU A 340
 PY1  A 700 (-3.6A)
PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.6A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
 0.67A 5i9xA-1py5A:
26.2		 5i9xA-1py5A:
26.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 621
LYS A 623
GLU A 640
THR A 670
TYR A 672
GLY A 676
LEU A 799
 STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
 0.94A 5i9xA-1t46A:
27.9		 5i9xA-1t46A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ILE A  34
ALA A  55
LYS A  57
GLU A  76
ILE A  89
TYR A 107
LEU A 158
 None
 0.86A 5i9xA-1u5qA:
24.7		 5i9xA-1u5qA:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ILE A  34
ALA A  55
LYS A  57
ILE A  89
TYR A 107
GLY A 110
LEU A 158
 None
 0.68A 5i9xA-1u5qA:
24.7		 5i9xA-1u5qA:
28.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA X  37
LYS X  39
GLU X  54
ILE X  80
THR X  82
TYR X  84
GLY X  88
LEU X 137
 STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-4.1A)
STU  X 902 (-4.6A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.82A 5i9xA-2dq7X:
32.3		 5i9xA-2dq7X:
41.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ILE A  34
ALA A  55
ILE A  89
TYR A 107
GLY A 110
GLU A 117
LEU A 158
 STU  A 400 (-4.2A)
STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
STU  A 400 (-4.5A)
STU  A 400 (-3.4A)
None
STU  A 400 ( 4.6A)
 1.39A 5i9xA-2gcdA:
25.5		 5i9xA-2gcdA:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ILE A  34
ALA A  55
LYS A  57
ILE A  89
TYR A 107
GLY A 110
LEU A 158
 STU  A 400 (-4.2A)
STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
STU  A 400 ( 4.5A)
STU  A 400 (-4.5A)
STU  A 400 (-3.4A)
STU  A 400 ( 4.6A)
 0.58A 5i9xA-2gcdA:
25.5		 5i9xA-2gcdA:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 293
ILE A 336
THR A 338
TYR A 340
GLY A 344
LEU A 393
 H8H  A 534 (-3.2A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.41A 5i9xA-2h8hA:
30.8		 5i9xA-2h8hA:
26.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 ILE A 635
ALA A 659
GLU A 678
ILE A 691
ILE A 705
THR A 707
GLY A 713
LEU A 761
 ADP  A 400 (-4.9A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.59A 5i9xA-2henA:
37.4		 5i9xA-2henA:
67.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 ILE A 635
ALA A 659
GLU A 678
ILE A 691
THR A 707
GLY A 713
LEU A 761
SER A 771
 ADP  A 400 (-4.9A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.74A 5i9xA-2henA:
37.4		 5i9xA-2henA:
67.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 271
LYS A 273
GLU A 288
ILE A 314
THR A 316
GLY A 322
LEU A 371
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.72A 5i9xA-2hk5A:
33.3		 5i9xA-2hk5A:
41.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 269
ILE A 313
THR A 315
GLY A 321
GLU A 329
LEU A 370
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
None
None
GIN  A 600 (-4.7A)
 0.57A 5i9xA-2hz0A:
31.1		 5i9xA-2hz0A:
37.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		6 ILE A 428
ALA A 452
LYS A 454
ILE A 497
GLY A 505
LEU A 553
 4ST  A1687 (-4.2A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.68A 5i9xA-2j0jA:
33.5		 5i9xA-2j0jA:
20.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 428
ALA A 452
GLU A 471
ILE A 497
GLY A 505
LEU A 553
 BII  A1687 (-3.8A)
BII  A1687 (-3.5A)
None
None
BII  A1687 (-3.6A)
BII  A1687 (-4.2A)
 0.63A 5i9xA-2jkmA:
33.6		 5i9xA-2jkmA:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 271
ILE A 314
THR A 316
TYR A 318
GLY A 322
LEU A 371
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
 0.59A 5i9xA-2og8A:
32.2		 5i9xA-2og8A:
40.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 515
GLU A 534
ILE A 548
TYR A 566
GLY A 570
LEU A 633
 None
 0.57A 5i9xA-2psqA:
32.4		 5i9xA-2psqA:
31.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		6 ILE B  47
ALA B  67
GLU B  85
TYR B 116
GLY B 120
LEU B 171
 None
 0.52A 5i9xA-2qkwB:
24.6		 5i9xA-2qkwB:
28.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 651
GLU A 670
ILE A 683
ILE A 697
THR A 699
GLY A 705
LEU A 753
 PTR  A 701 ( 4.7A)
None
None
None
None
None
None
 0.57A 5i9xA-2qobA:
37.5		 5i9xA-2qobA:
68.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		10 ILE A 681
ALA A 705
GLU A 724
ILE A 737
ILE A 751
THR A 753
TYR A 755
GLY A 759
LEU A 807
SER A 817
 None
 0.57A 5i9xA-2r2pA:
36.6		 5i9xA-2r2pA:
68.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  47
LYS A  49
GLU A  66
ILE A  93
TYR A  97
GLY A 101
LEU A 147
 J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
 0.73A 5i9xA-2xikA:
24.9		 5i9xA-2xikA:
29.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		10 ILE A 627
ALA A 651
LYS A 653
ILE A 683
ILE A 697
THR A 699
TYR A 701
GLY A 705
LEU A 753
SER A 763
 None
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 4.9A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-3.5A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
Q9G  A1898 (-3.2A)
 0.62A 5i9xA-2xyuA:
38.0		 5i9xA-2xyuA:
71.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  30
ALA A  51
ILE A  91
GLY A 113
LEU A 160
SER A 170
 B49  A1294 (-3.9A)
B49  A1294 (-3.2A)
B49  A1294 ( 4.6A)
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
B49  A1294 ( 4.9A)
 0.56A 5i9xA-2y7jA:
24.3		 5i9xA-2y7jA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  30
ALA A  51
LYS A  53
GLY A 113
LEU A 160
SER A 170
 B49  A1294 (-3.9A)
B49  A1294 (-3.2A)
None
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
B49  A1294 ( 4.9A)
 0.64A 5i9xA-2y7jA:
24.3		 5i9xA-2y7jA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 305
ALA A 326
LYS A 328
ILE A 374
TYR A 378
GLY A 382
 770  A 901 (-3.8A)
770  A 901 (-3.5A)
770  A 901 (-4.6A)
None
770  A 901 (-4.2A)
770  A 901 (-3.4A)
 0.67A 5i9xA-2z2wA:
24.2		 5i9xA-2z2wA:
26.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 273
GLU A 290
ILE A 317
THR A 319
GLY A 325
LEU A 374
 None
 0.50A 5i9xA-2zv7A:
27.4		 5i9xA-2zv7A:
40.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 515
LYS A 517
GLU A 534
ILE A 548
TYR A 566
GLY A 570
LEU A 633
 M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.75A 5i9xA-3b2tA:
32.2		 5i9xA-3b2tA:
35.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 512
LYS A 514
ILE A 545
TYR A 563
GLY A 567
LEU A 630
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 4.0A)
None
None
C4F  A   1 (-4.6A)
 0.69A 5i9xA-3c4fA:
32.0		 5i9xA-3c4fA:
33.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ILE A 201
ALA A 220
GLU A 236
ILE A 264
THR A 266
GLY A 272
LEU A 321
SER A 331
 None
 0.77A 5i9xA-3d7uA:
32.8		 5i9xA-3d7uA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ILE A 201
ALA A 220
ILE A 264
THR A 266
TYR A 268
GLY A 272
LEU A 321
SER A 331
 None
 0.65A 5i9xA-3d7uA:
32.8		 5i9xA-3d7uA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ILE A 201
ALA A 220
LYS A 222
GLU A 236
ILE A 264
THR A 266
GLY A 272
LEU A 321
 None
 0.97A 5i9xA-3d7uA:
32.8		 5i9xA-3d7uA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ILE A 201
ALA A 220
LYS A 222
ILE A 264
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.77A 5i9xA-3d7uA:
32.8		 5i9xA-3d7uA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ILE A 639
ALA A 663
LYS A 665
GLU A 682
ILE A 709
GLY A 717
LEU A 765
SER A 775
 IHZ  A1001 ( 4.8A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-3.7A)
 0.76A 5i9xA-3dkoA:
35.7		 5i9xA-3dkoA:
63.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 150
ALA A 169
LYS A 171
ILE A 204
GLY A 226
LEU A 275
 VIN  A6331 (-4.0A)
VIN  A6331 (-3.4A)
None
VIN  A6331 ( 4.9A)
VIN  A6331 (-3.4A)
VIN  A6331 (-4.5A)
 0.69A 5i9xA-3dtcA:
20.9		 5i9xA-3dtcA:
30.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 209
ALA A 228
GLU A 243
TYR A 281
GLY A 285
LEU A 340
SER A 350
 ADP  A 900 (-4.6A)
ADP  A 900 (-3.4A)
ADP  A 900 ( 4.7A)
None
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
None
 0.52A 5i9xA-3g2fA:
25.3		 5i9xA-3g2fA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 ILE A  59
ALA A  80
LYS A  82
TYR A 131
GLY A 135
LEU A 182
 None
 0.72A 5i9xA-3iecA:
23.4		 5i9xA-3iecA:
27.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ALA A 665
ILE A 697
ILE A 711
THR A 713
TYR A 715
GLY A 719
LEU A 767
SER A 777
 None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
None
 0.51A 5i9xA-3kulA:
35.5		 5i9xA-3kulA:
59.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ALA A 665
LYS A 667
ILE A 711
THR A 713
TYR A 715
GLY A 719
LEU A 767
 None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.65A 5i9xA-3kulA:
35.5		 5i9xA-3kulA:
59.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  60
LYS A  62
ILE A  94
TYR A 112
GLY A 116
LEU A 165
 QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
None
None
 0.71A 5i9xA-3lm5A:
24.6		 5i9xA-3lm5A:
27.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		8 ILE A 210
ALA A 229
LYS A 231
GLU A 244
THR A 279
TYR A 281
GLY A 285
LEU A 339
 LDN  A   1 (-4.1A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.70A 5i9xA-3mdyA:
25.5		 5i9xA-3mdyA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 227
GLU A 242
THR A 277
TYR A 279
GLY A 283
LEU A 337
 LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
 0.51A 5i9xA-3my0A:
25.5		 5i9xA-3my0A:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei) 		PF00069
(Pkinase) 		7 ILE A  34
ALA A  55
LYS A  57
GLU A  75
ILE A  88
ILE A 107
LEU A 161
 GOL  A 434 ( 4.5A)
GOL  A 434 ( 4.1A)
GOL  A 433 (-3.2A)
GOL  A 433 ( 4.8A)
None
None
GOL  A 434 (-4.2A)
 0.89A 5i9xA-3n9xA:
20.8		 5i9xA-3n9xA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 ILE A  36
ALA A  57
GLU A  77
ILE A  90
ILE A 109
LEU A 163
 ANP  A 430 (-4.4A)
ANP  A 430 (-3.5A)
ANP  A 430 ( 4.4A)
ANP  A 430 ( 4.5A)
None
ANP  A 430 (-4.4A)
 0.65A 5i9xA-3nieA:
21.6		 5i9xA-3nieA:
23.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 ILE A 557
ALA A 576
LYS A 578
ILE A 623
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-4.1A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.61A 5i9xA-3ppzA:
29.1		 5i9xA-3ppzA:
31.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LYS A 368
GLU A 384
THR A 413
TYR A 415
GLY A 419
LEU A 467
 STU  A   1 (-3.1A)
STU  A   1 (-3.7A)
STU  A   1 (-3.9A)
STU  A   1 (-4.7A)
STU  A   1 (-3.6A)
STU  A   1 (-4.6A)
 0.72A 5i9xA-3s95A:
26.4		 5i9xA-3s95A:
29.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 443
ILE A 487
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-3.2A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.39A 5i9xA-3sxsA:
31.5		 5i9xA-3sxsA:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A 625
ALA A 649
GLU A 668
ILE A 681
GLY A 703
LEU A 751
SER A 761
 None
 0.73A 5i9xA-3zfxA:
37.9		 5i9xA-3zfxA:
69.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ILE A 625
ALA A 649
GLU A 668
ILE A 681
ILE A 695
THR A 697
GLY A 703
LEU A 751
 None
 0.49A 5i9xA-3zfxA:
37.9		 5i9xA-3zfxA:
69.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 ILE A  83
ALA A 104
LYS A 106
TYR A 156
GLY A 160
LEU A 208
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1420 (-4.9A)
None
EDO  A1420 ( 4.8A)
 0.68A 5i9xA-4aw2A:
15.4		 5i9xA-4aw2A:
24.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ILE A  97
ALA A 121
GLU A 140
ILE A 153
ILE A 167
THR A 169
GLY A 175
LEU A 223
SER A 233
 30K  A1365 (-4.5A)
30K  A1365 (-3.2A)
None
None
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 ( 3.7A)
 0.53A 5i9xA-4aw5A:
37.5		 5i9xA-4aw5A:
66.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 ALA A 233
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
 TAK  A1507 (-3.3A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.51A 5i9xA-4c02A:
25.3		 5i9xA-4c02A:
27.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 ILE A 567
ALA A 588
GLU A 607
ILE A 634
GLY A 642
LEU A 690
SER A 700
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
None
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
 0.58A 5i9xA-4e93A:
34.6		 5i9xA-4e93A:
34.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A1148
GLU A1167
ILE A1194
GLY A1202
GLU A1210
LEU A1256
 0UV  A1501 (-3.4A)
None
None
0UV  A1501 (-3.6A)
0UV  A1501 (-3.7A)
0UV  A1501 (-4.6A)
 0.58A 5i9xA-4fodA:
32.7		 5i9xA-4fodA:
34.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 506
GLU A 525
ILE A 539
TYR A 557
GLY A 561
LEU A 624
 ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
None
ACP  A 801 ( 4.6A)
ACP  A 801 (-4.4A)
 0.66A 5i9xA-4k33A:
32.3		 5i9xA-4k33A:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 293
GLU A 310
ILE A 336
TYR A 340
GLY A 344
LEU A 393
 VGG  A 601 (-3.5A)
VGG  A 601 ( 4.3A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.69A 5i9xA-4lggA:
30.9		 5i9xA-4lggA:
40.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		9 ILE A 619
ALA A 644
ILE A 676
ILE A 690
THR A 692
TYR A 694
GLY A 698
GLU A 706
LEU A 746
 None
 0.66A 5i9xA-4p2kA:
36.3		 5i9xA-4p2kA:
94.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ILE A 619
ALA A 644
ILE A 676
TYR A 694
GLY A 698
LEU A 746
SER A 756
 None
 0.66A 5i9xA-4p2kA:
36.3		 5i9xA-4p2kA:
94.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ILE A 619
GLU A 663
ILE A 676
ILE A 690
THR A 692
GLY A 698
LEU A 746
 None
 0.96A 5i9xA-4p2kA:
36.3		 5i9xA-4p2kA:
94.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 ALA A  35
GLU A  52
ILE A  79
THR A  81
TYR A  83
GLY A  87
LEU A 136
 ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.48A 5i9xA-4ueuA:
33.5		 5i9xA-4ueuA:
44.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 ALA A  35
LYS A  37
GLU A  52
ILE A  79
THR A  81
TYR A  83
LEU A 136
 ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
 0.72A 5i9xA-4ueuA:
33.5		 5i9xA-4ueuA:
44.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 ALA B 288
ILE B 332
THR B 334
GLY B 340
GLU B 348
LEU B 389
 1N1  B 601 (-3.5A)
1N1  B 601 (-4.1A)
1N1  B 601 (-3.3A)
1N1  B 601 (-3.5A)
None
1N1  B 601 (-4.3A)
 0.52A 5i9xA-4xeyB:
32.2		 5i9xA-4xeyB:
31.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ALA A 428
ILE A 472
THR A 474
TYR A 476
GLY A 480
LEU A 528
SER A 538
 None
 0.84A 5i9xA-4xi2A:
30.5		 5i9xA-4xi2A:
29.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		7 ALA A 428
ILE A 472
THR A 474
TYR A 476
GLY A 480
GLU A 488
LEU A 528
 746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
CA  A 703 ( 4.5A)
746  A 702 (-4.4A)
 0.82A 5i9xA-4y93A:
31.4		 5i9xA-4y93A:
26.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ILE A 469
ALA A 488
GLU A 509
ILE A 522
ILE A 537
THR A 539
TYR A 541
GLU A 553
 4CV  A 801 (-4.3A)
4CV  A 801 (-3.5A)
None
4CV  A 801 ( 4.2A)
None
4CV  A 801 (-2.8A)
4CV  A 801 (-3.9A)
None
 0.99A 5i9xA-4yffA:
26.1		 5i9xA-4yffA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ILE A 469
ALA A 488
ILE A 522
ILE A 537
THR A 539
TYR A 541
GLY A 545
GLU A 553
LEU A 595
 4CV  A 801 (-4.3A)
4CV  A 801 (-3.5A)
4CV  A 801 ( 4.2A)
None
4CV  A 801 (-2.8A)
4CV  A 801 (-3.9A)
4CV  A 801 ( 4.0A)
None
4CV  A 801 (-4.4A)
 1.39A 5i9xA-4yffA:
26.1		 5i9xA-4yffA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A 469
ALA A 488
LYS A 490
GLU A 509
ILE A 537
THR A 539
TYR A 541
 4CV  A 801 (-4.3A)
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
None
4CV  A 801 (-2.8A)
4CV  A 801 (-3.9A)
 0.98A 5i9xA-4yffA:
26.1		 5i9xA-4yffA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ILE A 469
ALA A 488
LYS A 490
ILE A 537
THR A 539
TYR A 541
GLY A 545
LEU A 595
 4CV  A 801 (-4.3A)
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
4CV  A 801 (-2.8A)
4CV  A 801 (-3.9A)
4CV  A 801 ( 4.0A)
4CV  A 801 (-4.4A)
 0.71A 5i9xA-4yffA:
26.1		 5i9xA-4yffA:
30.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 ALA A 597
GLU A 612
ILE A 626
ILE A 640
LEU A 695
SER A 710
 None
 0.69A 5i9xA-4z7gA:
20.8		 5i9xA-4z7gA:
22.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 512
GLU A 531
ILE A 545
TYR A 563
GLY A 567
LEU A 630
 38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.69A 5i9xA-5a46A:
32.8		 5i9xA-5a46A:
31.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  22
ALA A  44
GLU A  63
TYR A  94
GLY A  98
LEU A 145
 51W  A 401 (-3.9A)
51W  A 401 (-3.4A)
None
51W  A 401 ( 3.4A)
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
 0.66A 5i9xA-5ci7A:
23.4		 5i9xA-5ci7A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 ILE A  62
ALA A  83
LYS A  85
TYR A 134
GLY A 138
LEU A 185
 5RC  A4000 (-4.0A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
5RC  A4000 (-4.5A)
5RC  A4000 (-3.3A)
None
 0.71A 5i9xA-5es1A:
23.5		 5i9xA-5es1A:
26.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 928
GLU A 947
ILE A 960
TYR A 980
GLY A 984
LEU A1030
 5U3  A1200 (-3.5A)
None
5U3  A1200 (-4.6A)
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.63A 5i9xA-5f1zA:
27.8		 5i9xA-5f1zA:
31.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 756
GLU A 775
ILE A 788
TYR A 806
GLY A 810
LEU A 881
 PP1  A2012 (-3.2A)
PP1  A2012 (-3.5A)
None
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.55A 5i9xA-5fm2A:
31.8		 5i9xA-5fm2A:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 756
ILE A 788
TYR A 806
GLY A 810
LEU A 881
SER A 891
 PP1  A2012 (-3.2A)
None
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
PP1  A2012 (-3.1A)
 0.67A 5i9xA-5fm2A:
31.8		 5i9xA-5fm2A:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 625
LYS A 627
GLU A 644
ILE A 672
THR A 674
TYR A 676
LEU A 825
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.96A 5i9xA-5grnA:
32.9		 5i9xA-5grnA:
31.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 625
LYS A 627
ILE A 672
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.69A 5i9xA-5grnA:
32.9		 5i9xA-5grnA:
31.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 105
ILE A 146
THR A 148
TYR A 150
GLY A 154
LEU A 215
 None
 0.49A 5i9xA-5gz8A:
19.6		 5i9xA-5gz8A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gza PROTEIN O-MANNOSE
KINASE

(Danio rerio) 		PF07714
(Pkinase_Tyr) 		6 ILE A  85
ALA A 104
THR A 147
TYR A 149
GLY A 153
LEU A 214
 ADP  A 401 ( 4.9A)
ADP  A 401 (-3.2A)
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.1A)
ADP  A 401 (-4.4A)
 0.57A 5i9xA-5gzaA:
19.4		 5i9xA-5gzaA:
27.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A  43
LYS A  45
ILE A  66
ILE A  80
THR A  82
TYR A  84
GLY A  88
 032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 (-4.4A)
032  A 401 (-4.0A)
032  A 401 (-3.7A)
032  A 401 (-4.2A)
032  A 401 ( 4.0A)
 0.60A 5i9xA-5hesA:
27.2		 5i9xA-5hesA:
30.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  77
LYS A  79
ILE A 128
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.58A 5i9xA-5i3oA:
23.0		 5i9xA-5i3oA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  22
ALA A  43
LYS A  45
ILE A  88
GLY A  96
LEU A 143
 6G2  A 901 (-3.8A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.56A 5i9xA-5j5tA:
22.5		 5i9xA-5j5tA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 276
ALA A 297
LYS A 299
TYR A 346
GLY A 350
LEU A 396
 IPW  A 601 (-4.0A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.71A 5i9xA-5kbrA:
22.3		 5i9xA-5kbrA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 228
LYS A 230
GLU A 250
ILE A 281
TYR A 285
GLY A 289
LEU A 338
 6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
None
6UY  A 501 ( 4.8A)
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
 0.62A 5i9xA-5ko1A:
28.6		 5i9xA-5ko1A:
29.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A 639
ALA A 663
LYS A 665
ILE A 695
ILE A 709
THR A 711
LEU A 765
 6P6  A1001 (-4.0A)
6P6  A1001 (-3.3A)
None
None
6P6  A1001 ( 4.5A)
6P6  A1001 (-3.5A)
6P6  A1001 (-4.5A)
 0.53A 5i9xA-5l6oA:
36.4		 5i9xA-5l6oA:
68.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ILE A 889
ALA A 909
GLU A 927
GLY A 962
LEU A1016
SER A1026
 ADP  A1200 (-4.7A)
ADP  A1200 (-3.5A)
None
ADP  A1200 ( 4.0A)
ADP  A1200 (-4.7A)
ADP  A1200 ( 4.6A)
 0.63A 5i9xA-5lpzA:
23.9		 5i9xA-5lpzA:
29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  98
ALA A 119
LYS A 121
GLU A 140
TYR A 171
GLY A 175
LEU A 221
 None
 0.83A 5i9xA-5u7qA:
15.4		 5i9xA-5u7qA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 218
ALA A 239
LYS A 241
ILE A 287
TYR A 291
GLY A 295
 8X7  A 501 ( 4.0A)
8X7  A 501 ( 3.7A)
PO4  A 502 (-3.6A)
PO4  A 502 (-3.4A)
8X7  A 501 (-4.2A)
8X7  A 501 (-3.6A)
 0.57A 5i9xA-5vdkA:
22.7		 5i9xA-5vdkA:
25.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vo1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 12

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 150
ILE A 174
ILE A 188
GLY A 196
LEU A 243
SER A 253
 9FS  A 501 (-3.4A)
None
None
9FS  A 501 (-3.6A)
9FS  A 501 (-4.7A)
9FS  A 501 ( 4.3A)
 0.56A 5i9xA-5vo1A:
25.8		 5i9xA-5vo1A:
31.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 7 ALA A  45
ILE A  93
THR A  95
TYR A  97
GLY A 101
GLU A 112
LEU A 153
 9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
None
9WS  A 401 (-4.6A)
 1.16A 5i9xA-5w5jA:
24.0		 5i9xA-5w5jA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 6 ALA A  49
LYS A  51
TYR A  98
GLY A 102
LEU A 150
SER A 160
 VX6  A 402 (-3.2A)
VX6  A 402 (-4.9A)
VX6  A 402 (-4.3A)
VX6  A 402 (-3.5A)
VX6  A 402 (-4.4A)
VX6  A 402 (-3.3A)
 0.68A 5i9xA-5wnmA:
28.4		 5i9xA-5wnmA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 7 ALA A 917
LYS A 919
ILE A 961
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.66A 5i9xA-5wnoA:
27.9		 5i9xA-5wnoA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 6 ALA A 211
LYS A 213
TYR A 264
GLY A 268
LEU A 318
SER A 328
 CJT  A 502 (-3.4A)
CJT  A 502 (-3.0A)
CJT  A 502 (-4.5A)
CJT  A 502 ( 4.3A)
CJT  A 502 (-4.7A)
CJT  A 502 ( 4.3A)
 0.43A 5i9xA-6f3dA:
25.1		 5i9xA-6f3dA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 6 ALA A 756
GLU A 775
ILE A 788
TYR A 806
GLY A 810
LEU A 881
 ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.7A)
ADN  A1104 ( 4.1A)
ADN  A1104 ( 3.8A)
ADN  A1104 (-4.3A)
 0.52A 5i9xA-6fekA:
30.9		 5i9xA-6fekA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 7 ALA A 189
LYS A 191
GLU A 206
ILE A 239
GLY A 245
GLU A 254
LEU A 295
 EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
None
EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-4.9A)
 1.29A 5i9xA-6fyoA:
22.7		 5i9xA-6fyoA:
undetectable