SIMILAR PATTERNS OF AMINO ACIDS FOR 5I8F_A_ML1A211_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		4 VAL A  15
ALA A  88
GLN A  79
VAL A  78
 None
 0.97A 5i8fA-1dgmA:
1.2		 5i8fA-1dgmA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i0r CONSERVED
HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF01613
(Flavin_Reduct) 		4 VAL A  32
ALA A  29
GLN A  27
VAL A  16
 None
FMN  A2000 (-3.7A)
FMN  A2000 (-3.6A)
None
 1.05A 5i8fA-1i0rA:
0.0		 5i8fA-1i0rA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7s FERRICHROME-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		4 VAL N 287
ALA N 291
GLN N 267
VAL N 269
 None
 0.96A 5i8fA-1k7sN:
0.0		 5i8fA-1k7sN:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9m RIBOSOMAL PROTEIN
L10E

(Haloarcula
marismortui) 		PF00252
(Ribosomal_L16) 		4 VAL J 142
ALA J 134
VAL J 136
TYR J  81
 None
 1.02A 5i8fA-1k9mJ:
0.0		 5i8fA-1k9mJ:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbl PYRUVATE PHOSPHATE
DIKINASE

([Clostridium]
symbiosum) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 VAL A 147
ALA A 190
VAL A 186
TYR A 187
 None
 1.00A 5i8fA-1kblA:
0.0		 5i8fA-1kblA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kij DNA GYRASE SUBUNIT B

(Thermus
thermophilus) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 LYS A 227
ALA A 226
VAL A 222
TYR A 196
 None
 1.05A 5i8fA-1kijA:
0.0		 5i8fA-1kijA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 VAL B 370
LYS B 373
VAL B 329
TYR B 339
 None
 0.83A 5i8fA-1mu2B:
2.0		 5i8fA-1mu2B:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE

(Escherichia
coli) 		PF00218
(IGPS)
PF00697
(PRAI) 		4 VAL A 319
LYS A 322
ALA A 323
VAL A 331
 None
 0.94A 5i8fA-1piiA:
0.0		 5i8fA-1piiA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pov POLIOVIRUS NATIVE
EMPTY CAPSID (TYPE
1)

(Enterovirus C) 		PF00073
(Rhv)
PF02226
(Pico_P1A) 		4 VAL 0 179
ALA 0 275
GLN 0 265
VAL 0 193
 None
 1.06A 5i8fA-1pov0:
0.0		 5i8fA-1pov0:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		4 VAL A 230
ALA A 228
GLN A 240
VAL A 239
 None
NAG  A 812 (-4.9A)
NAG  A 812 (-4.2A)
None
 1.03A 5i8fA-1q5aA:
undetectable		 5i8fA-1q5aA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qqh PAPILLOMAVIRUS
TRANSCRIPTION FACTOR
E2

(Alphapapillomavirus
7) 		PF00508
(PPV_E2_N) 		4 VAL A 187
GLN A 118
VAL A 117
TYR A 131
 None
 1.04A 5i8fA-1qqhA:
undetectable		 5i8fA-1qqhA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tue REGULATORY PROTEIN
E2

(Alphapapillomavirus
7) 		PF00508
(PPV_E2_N) 		4 VAL B 191
GLN B 122
VAL B 121
TYR B 135
 None
 1.02A 5i8fA-1tueB:
undetectable		 5i8fA-1tueB:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 467
ALA A 475
GLN A 444
VAL A 445
 None
 0.89A 5i8fA-1u59A:
undetectable		 5i8fA-1u59A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uqx LECTIN

(Ralstonia
solanacearum) 		PF07472
(PA-IIL) 		4 VAL A  30
ALA A  38
GLN A  53
VAL A  16
 None
 0.91A 5i8fA-1uqxA:
undetectable		 5i8fA-1uqxA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Thermus
thermophilus) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 VAL A 262
ALA A 133
VAL A 265
TYR A 264
 None
 1.02A 5i8fA-1x1oA:
undetectable		 5i8fA-1x1oA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydg TRP REPRESSOR
BINDING PROTEIN WRBA

(Deinococcus
radiodurans) 		PF03358
(FMN_red) 		4 VAL A   5
ALA A  79
GLN A 191
VAL A 192
 None
 1.03A 5i8fA-1ydgA:
undetectable		 5i8fA-1ydgA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq9 PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
gigas) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 VAL A  99
LYS A 102
ALA A 103
VAL A  10
 None
GOL  A1273 (-4.1A)
None
None
 0.84A 5i8fA-1yq9A:
undetectable		 5i8fA-1yq9A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyo SERINE PROTEASE

(Sesbania mosaic
virus) 		PF02122
(Peptidase_S39) 		4 LYS A 194
ALA A 193
GLN A 198
VAL A 199
 None
 1.06A 5i8fA-1zyoA:
undetectable		 5i8fA-1zyoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyo SERINE PROTEASE

(Sesbania mosaic
virus) 		PF02122
(Peptidase_S39) 		4 VAL A 153
LYS A 194
ALA A 193
GLN A 198
 None
 1.04A 5i8fA-1zyoA:
undetectable		 5i8fA-1zyoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 197
ALA A 151
GLN A 155
VAL A 156
 None
None
AIZ  A 501 (-2.6A)
None
 0.87A 5i8fA-2b1pA:
undetectable		 5i8fA-2b1pA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpg GLUCOSE 6-PHOSPHATE
DEHYDROGENASE

(Leuconostoc
mesenteroides) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		4 VAL A 449
LYS A 454
ALA A 455
VAL A 280
 None
 1.05A 5i8fA-2dpgA:
undetectable		 5i8fA-2dpgA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drm ACANTHAMOEBA MYOSIN
IB

(Acanthamoeba) 		PF00018
(SH3_1) 		4 VAL A  51
ALA A  53
VAL A  56
TYR A  55
 None
 1.06A 5i8fA-2drmA:
undetectable		 5i8fA-2drmA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffj CONSERVED
HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF01937
(DUF89) 		4 VAL A  15
ALA A  19
VAL A  61
TYR A  62
 None
 1.05A 5i8fA-2ffjA:
undetectable		 5i8fA-2ffjA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fq1 ISOCHORISMATASE

(Escherichia
coli) 		PF00550
(PP-binding)
PF00857
(Isochorismatase) 		4 VAL A 120
ALA A  78
GLN A  39
VAL A 108
 None
 1.01A 5i8fA-2fq1A:
undetectable		 5i8fA-2fq1A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpc IRON SUPEROXIDE
DISMUTASE

(Trypanosoma
cruzi) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 VAL A 115
ALA A 125
VAL A 138
TYR A 139
 None
 0.99A 5i8fA-2gpcA:
undetectable		 5i8fA-2gpcA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gs5 CONSERVED
HYPOTHETICAL PROTEIN

(Corynebacterium
diphtheriae) 		PF02622
(DUF179) 		4 VAL A  20
ALA A 158
GLN A 181
VAL A 177
 None
 0.93A 5i8fA-2gs5A:
undetectable		 5i8fA-2gs5A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kzh TRYPTOPHAN
BIOSYNTHESIS PROTEIN
TRPCF

(Escherichia
coli) 		PF00697
(PRAI) 		4 VAL A  66
LYS A  69
ALA A  70
VAL A  78
 None
 0.83A 5i8fA-2kzhA:
undetectable		 5i8fA-2kzhA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m1w TIR
DOMAIN-CONTAINING
ADAPTER MOLECULE 2

(Homo sapiens) 		PF13676
(TIR_2) 		4 ALA A 133
GLN A 218
VAL A 214
TYR A 215
 None
 1.07A 5i8fA-2m1wA:
undetectable		 5i8fA-2m1wA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 784
ALA A 792
GLN A 761
VAL A 762
 None
 1.02A 5i8fA-2ogvA:
undetectable		 5i8fA-2ogvA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		4 VAL A 467
ALA A 475
GLN A 444
VAL A 445
 None
 0.86A 5i8fA-2ozoA:
undetectable		 5i8fA-2ozoA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3

(Homo sapiens) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 VAL A 242
ALA A 239
GLN A 216
VAL A 198
 None
 1.00A 5i8fA-2qk4A:
undetectable		 5i8fA-2qk4A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 VAL G2003
ALA G2007
GLN G2020
VAL G2021
 None
 0.67A 5i8fA-2uv8G:
undetectable		 5i8fA-2uv8G:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Thermus
thermophilus) 		PF09488
(Osmo_MPGsynth) 		4 VAL A 340
ALA A 336
VAL A 330
TYR A 331
 None
 1.07A 5i8fA-2wvlA:
undetectable		 5i8fA-2wvlA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xiv HYPOTHETICAL
INVASION PROTEIN

(Mycobacterium
tuberculosis) 		PF00877
(NLPC_P60) 		4 VAL A 286
ALA A 295
GLN A 299
VAL A 300
 None
 0.91A 5i8fA-2xivA:
undetectable		 5i8fA-2xivA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y35 LD22664P

(Drosophila
melanogaster) 		PF03159
(XRN_N) 		4 LYS A  93
ALA A  92
VAL A 446
TYR A 449
 None
 0.98A 5i8fA-2y35A:
undetectable		 5i8fA-2y35A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c12 FLAGELLAR PROTEIN

(Xanthomonas
campestris) 		PF13860
(FlgD_ig)
PF13861
(FLgD_tudor) 		4 VAL A 115
ALA A  84
GLN A 140
VAL A  90
 None
 0.98A 5i8fA-3c12A:
undetectable		 5i8fA-3c12A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9f 5'-NUCLEOTIDASE

(Candida
albicans) 		PF00149
(Metallophos) 		4 ALA A 193
GLN A 229
VAL A 230
TYR A 233
 None
 1.04A 5i8fA-3c9fA:
undetectable		 5i8fA-3c9fA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpr PROTEIN VP2

(Rhinovirus A) 		PF00073
(Rhv) 		4 VAL B 110
ALA B 200
GLN B 190
VAL B 124
 None
 0.98A 5i8fA-3dprB:
undetectable		 5i8fA-3dprB:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 159
ALA A 113
GLN A 117
VAL A 118
 None
35F  A   1 (-4.9A)
35F  A   1 ( 4.5A)
None
 0.96A 5i8fA-3e7oA:
undetectable		 5i8fA-3e7oA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fac PUTATIVE
UNCHARACTERIZED
PROTEIN

(Rhodobacter
sphaeroides) 		PF04828
(GFA) 		4 VAL A  14
ALA A  41
VAL A  90
TYR A  88
 None
 0.98A 5i8fA-3facA:
undetectable		 5i8fA-3facA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fh2 PROBABLE
ATP-DEPENDENT
PROTEASE (HEAT SHOCK
PROTEIN)

(Corynebacterium
glutamicum) 		PF02861
(Clp_N) 		4 VAL A  44
LYS A  47
ALA A  48
VAL A 138
 None
 0.64A 5i8fA-3fh2A:
undetectable		 5i8fA-3fh2A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd 5'-3'
EXORIBONUCLEASE 2

(Schizosaccharomyces
pombe) 		PF03159
(XRN_N) 		4 LYS A 111
ALA A 110
VAL A 624
TYR A 627
 None
 0.81A 5i8fA-3fqdA:
undetectable		 5i8fA-3fqdA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3l PUTATIVE
UNCHARACTERIZED
MEMBRANE-ASSOCIATED
PROTEIN

(Bacteroides
fragilis) 		PF12985
(DUF3869) 		4 VAL A 130
ALA A 128
VAL A 124
TYR A  98
 None
 0.93A 5i8fA-3g3lA:
2.4		 5i8fA-3g3lA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9v INTERLEUKIN 22
RECEPTOR, ALPHA 2

(Homo sapiens) 		PF01108
(Tissue_fac)
PF09294
(Interfer-bind) 		4 VAL A 144
ALA A 193
VAL A 173
TYR A 171
 None
 0.91A 5i8fA-3g9vA:
undetectable		 5i8fA-3g9vA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbp GALACTOSE-BINDING
PROTEIN

(Salmonella
enterica) 		PF13407
(Peripla_BP_4) 		4 VAL A  76
LYS A  79
ALA A  80
VAL A  87
 None
 1.07A 5i8fA-3gbpA:
undetectable		 5i8fA-3gbpA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcc T-CELL SURFACE
GLYCOPROTEIN CD4

(Homo sapiens) 		PF00047
(ig)
PF05790
(C2-set) 		4 VAL D   4
GLN D  94
VAL D  93
TYR D  82
 None
 0.97A 5i8fA-3jccD:
undetectable		 5i8fA-3jccD:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kly PUTATIVE FORMATE
TRANSPORTER 1

(Vibrio cholerae) 		PF01226
(Form_Nir_trans) 		4 LYS A  99
ALA A  98
VAL A 269
TYR A 273
 None
 1.08A 5i8fA-3klyA:
undetectable		 5i8fA-3klyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kp1 D-ORNITHINE
AMINOMUTASE S
COMPONENT

(Acetoanaerobium
sticklandii) 		PF16552
(OAM_alpha) 		4 VAL E  96
ALA E  89
VAL E  85
TYR E  86
 None
 1.02A 5i8fA-3kp1E:
undetectable		 5i8fA-3kp1E:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9t PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.31

(Streptococcus
mutans) 		PF08713
(DNA_alkylation) 		4 VAL A  89
LYS A  92
ALA A  93
VAL A  58
 None
 1.07A 5i8fA-3l9tA:
undetectable		 5i8fA-3l9tA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la2 GLOBAL NITROGEN
REGULATOR

(Nostoc sp. PCC
7120) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 VAL A  44
ALA A 103
GLN A 107
VAL A 108
 None
 1.01A 5i8fA-3la2A:
undetectable		 5i8fA-3la2A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		4 VAL A 585
ALA A 583
VAL A 429
TYR A 428
 None
 1.06A 5i8fA-3mc2A:
undetectable		 5i8fA-3mc2A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Rubrobacter
xylanophilus) 		PF00535
(Glycos_transf_2) 		4 VAL A 162
GLN A 248
VAL A 249
TYR A  23
 None
 1.02A 5i8fA-3o3pA:
undetectable		 5i8fA-3o3pA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oq9 PROTEIN FADD

(Homo sapiens) 		PF00531
(Death) 		4 VAL H 103
ALA H 100
GLN H 181
VAL H 180
 None
 1.06A 5i8fA-3oq9H:
undetectable		 5i8fA-3oq9H:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6d PUTATIVE
TRIOSEPHOSPHATE
ISOMERASE

(Coccidioides
immitis) 		PF00121
(TIM) 		4 VAL A 141
LYS A 144
ALA A 145
VAL A 157
 None
 0.84A 5i8fA-3s6dA:
undetectable		 5i8fA-3s6dA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ta6 TRIOSEPHOSPHATE
ISOMERASE

(Mycobacterium
tuberculosis) 		PF00121
(TIM) 		4 VAL A 114
LYS A 117
ALA A 118
VAL A 130
 None
 1.02A 5i8fA-3ta6A:
undetectable		 5i8fA-3ta6A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waz PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
abyssi) 		PF09522
(RE_R_Pab1) 		4 VAL A 158
ALA A 154
GLN A 161
TYR A 160
 None
 1.06A 5i8fA-3wazA:
undetectable		 5i8fA-3wazA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zny CTX-M-12A ENZYME

(Klebsiella
pneumoniae) 		PF13354
(Beta-lactamase2) 		4 LYS A 271
ALA A 272
GLN A 267
TYR A 241
 None
 0.96A 5i8fA-3znyA:
undetectable		 5i8fA-3znyA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 VAL A 466
ALA A 470
GLN A 496
VAL A 497
 None
 0.71A 5i8fA-3zz1A:
undetectable		 5i8fA-3zz1A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au0 EXOGLUCANASE 2

(Trichoderma
reesei) 		PF01341
(Glyco_hydro_6) 		4 VAL A 250
ALA A 290
VAL A 286
TYR A 287
 None
None
NAG  A 501 ( 4.5A)
None
 0.83A 5i8fA-4au0A:
undetectable		 5i8fA-4au0A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b09 TRANSCRIPTIONAL
REGULATORY PROTEIN
BAER

(Escherichia
coli) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 VAL A  16
GLN A  45
VAL A  46
TYR A  49
 None
 0.72A 5i8fA-4b09A:
undetectable		 5i8fA-4b09A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr2 26S PROTEASE
REGULATORY SUBUNIT 4
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		4 VAL I 120
ALA I 118
VAL I 130
TYR I 129
 None
 0.77A 5i8fA-4cr2I:
undetectable		 5i8fA-4cr2I:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cta CINA-LIKE PROTEIN

(Thermus
thermophilus) 		PF00994
(MoCF_biosynth)
PF02464
(CinA) 		4 VAL A 298
LYS A 301
ALA A 302
GLN A 308
 None
GOL  A 404 (-2.8A)
None
None
 0.99A 5i8fA-4ctaA:
2.4		 5i8fA-4ctaA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		4 VAL A 330
ALA A 268
GLN A 294
VAL A 299
 None
 0.78A 5i8fA-4cvuA:
undetectable		 5i8fA-4cvuA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 500
ALA A 508
GLN A 477
VAL A 478
 None
 0.86A 5i8fA-4f4pA:
undetectable		 5i8fA-4f4pA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		4 VAL A 500
ALA A 508
GLN A 477
VAL A 478
 None
 0.88A 5i8fA-4fl3A:
undetectable		 5i8fA-4fl3A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwg TTC1975 PEPTIDASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C)
PF13654
(AAA_32) 		4 VAL A 632
ALA A 635
GLN A 483
VAL A 482
 None
 1.00A 5i8fA-4fwgA:
undetectable		 5i8fA-4fwgA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1k TRIOSEPHOSPHATE
ISOMERASE

(Burkholderia
thailandensis) 		PF00121
(TIM) 		4 VAL A 113
LYS A 116
ALA A 117
VAL A 129
 None
 1.02A 5i8fA-4g1kA:
undetectable		 5i8fA-4g1kA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia) 		PF00933
(Glyco_hydro_3) 		4 VAL A 293
ALA A 289
GLN A 286
VAL A 283
 None
 1.01A 5i8fA-4g6cA:
undetectable		 5i8fA-4g6cA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5u CHIMERIC CEL6A

(Chaetomium
thermophilum;
Humicola
insolens;
Trichoderma
reesei) 		PF01341
(Glyco_hydro_6) 		4 VAL A 251
ALA A 291
VAL A 287
TYR A 288
 None
None
ACT  A 501 (-4.0A)
None
 0.83A 5i8fA-4i5uA:
undetectable		 5i8fA-4i5uA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n54 INOSITOL
DEHYDROGENASE

(Lactobacillus
casei) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 VAL A 213
LYS A 216
ALA A 217
VAL A 168
 None
 0.91A 5i8fA-4n54A:
undetectable		 5i8fA-4n54A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nur PSDSA

(Pseudomonas sp.
S9) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 VAL A 475
LYS A 478
ALA A 479
VAL A 494
 None
 1.01A 5i8fA-4nurA:
undetectable		 5i8fA-4nurA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oo3 HYPOTHETICAL PROTEIN

(Parabacteroides
merdae) 		PF01408
(GFO_IDH_MocA)
PF16490
(Oxidoreduct_C) 		4 VAL A 368
ALA A 350
VAL A 193
TYR A 194
 None
 0.86A 5i8fA-4oo3A:
undetectable		 5i8fA-4oo3A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4g PEPTIDOGLYCAN
ENDOPEPTIDASE RIPA

(Mycobacterium
tuberculosis) 		PF00877
(NLPC_P60) 		4 VAL X1024
ALA X1033
GLN X1037
VAL X1038
 None
 0.95A 5i8fA-4q4gX:
undetectable		 5i8fA-4q4gX:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rf7 ARGININE KINASE

(Anthopleura
japonica) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 VAL A 112
LYS A 113
ALA A 114
VAL A 345
 None
 1.02A 5i8fA-4rf7A:
undetectable		 5i8fA-4rf7A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF05470
(eIF-3c_N) 		4 VAL C 498
LYS C 500
ALA C 502
VAL C 434
 None
 1.06A 5i8fA-4u1cC:
undetectable		 5i8fA-4u1cC:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uer EIF3C

(Lachancea
kluyveri) 		PF00189
(Ribosomal_S3_C)
PF07650
(KH_2) 		4 VAL c 498
LYS c 500
ALA c 502
VAL c 434
 None
 1.07A 5i8fA-4uerc:
undetectable		 5i8fA-4uerc:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 VAL A 269
ALA A 281
GLN A 191
VAL A 192
 None
 0.87A 5i8fA-4wd1A:
undetectable		 5i8fA-4wd1A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0l HAPTOGLOBIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 VAL C 231
GLN C 229
VAL C 225
TYR C 224
 None
 0.94A 5i8fA-4x0lC:
undetectable		 5i8fA-4x0lC:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8q UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF08713
(DNA_alkylation) 		4 VAL A  89
LYS A  92
ALA A  93
VAL A  58
 None
NA  A 303 ( 4.0A)
None
None
 1.06A 5i8fA-4x8qA:
undetectable		 5i8fA-4x8qA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhp PARM HYBRID FUSION
PROTEIN

(Bacillus
thuringiensis) 		no annotation 4 LYS A 541
ALA A 540
VAL A 536
TYR A 539
 None
 1.04A 5i8fA-4xhpA:
undetectable		 5i8fA-4xhpA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)

(Candidatus
Korarchaeum
cryptofilum) 		PF13549
(ATP-grasp_5) 		4 VAL B  96
ALA B 103
GLN B  65
VAL B  66
 None
 1.06A 5i8fA-4xymB:
undetectable		 5i8fA-4xymB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y90 TRIOSEPHOSPHATE
ISOMERASE

(Deinococcus
radiodurans) 		PF00121
(TIM) 		4 VAL A 110
LYS A 113
ALA A 114
VAL A 126
 None
 0.91A 5i8fA-4y90A:
undetectable		 5i8fA-4y90A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4l CELLOBIOSE
2-EPIMERASE

(Caldicellulosiruptor
saccharolyticus) 		PF07221
(GlcNAc_2-epim) 		4 VAL A 189
ALA A 117
VAL A 113
TYR A 114
 None
 1.03A 5i8fA-4z4lA:
undetectable		 5i8fA-4z4lA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		4 VAL A 157
ALA A 111
GLN A 115
VAL A 116
 None
 0.97A 5i8fA-5awmA:
undetectable		 5i8fA-5awmA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dsy POLY [ADP-RIBOSE]
POLYMERASE 2

(Homo sapiens) 		PF00644
(PARP) 		4 VAL A 516
GLN A 371
VAL A 368
TYR A 372
 None
 0.75A 5i8fA-5dsyA:
undetectable		 5i8fA-5dsyA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eq6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILM

(Pseudomonas
aeruginosa) 		PF11104
(PilM_2) 		4 VAL A  67
LYS A  70
ALA A  71
TYR A  39
 None
 0.64A 5i8fA-5eq6A:
undetectable		 5i8fA-5eq6A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG

(Caenorhabditis
elegans) 		PF03159
(XRN_N) 		4 LYS A 110
ALA A 109
VAL A 575
TYR A 578
 SO4  A1788 (-3.2A)
None
None
None
 0.88A 5i8fA-5firA:
1.3		 5i8fA-5firA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im3 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Pseudomonas
aeruginosa) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 VAL A 105
ALA A 108
GLN A  81
VAL A  82
 None
 1.03A 5i8fA-5im3A:
undetectable		 5i8fA-5im3A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd8 PERIPLASMIC SERINE
PEPTIDASE DEGS

(Yersinia pestis) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 VAL A  52
ALA A  56
GLN A 165
VAL A 167
 None
 0.94A 5i8fA-5jd8A:
undetectable		 5i8fA-5jd8A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 2

(Sus scrofa) 		no annotation 4 VAL A 647
LYS A 650
ALA A 651
VAL A 632
 None
 0.67A 5i8fA-5mpmA:
2.1		 5i8fA-5mpmA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 4 VAL B 375
ALA B 273
GLN B 294
VAL B 295
 None
 1.03A 5i8fA-5n5nB:
undetectable		 5i8fA-5n5nB:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ney FUCOSE-BINDING
LECTIN II (PA-IIL)

(Pseudomonas
aeruginosa) 		PF07472
(PA-IIL) 		4 VAL A  30
ALA A  38
GLN A  53
VAL A  16
 None
 1.05A 5i8fA-5neyA:
undetectable		 5i8fA-5neyA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o60 50S RIBOSOMAL
PROTEIN L24

(Mycolicibacterium
smegmatis) 		PF00467
(KOW)
PF17136
(ribosomal_L24) 		4 VAL V  83
LYS V  99
ALA V  98
VAL V  73
 None
A  A 380 ( 2.4A)
None
None
 1.06A 5i8fA-5o60V:
undetectable		 5i8fA-5o60V:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5owx GENOME POLYPROTEIN

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		4 VAL 2 109
ALA 2 156
GLN 2 146
VAL 2 123
 None
 0.93A 5i8fA-5owx2:
undetectable		 5i8fA-5owx2:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uso PROTECTION OF
TELOMERES PROTEIN 1

(Schizosaccharomyces
pombe) 		no annotation 4 VAL A  23
ALA A  21
VAL A  89
TYR A  88
 None
 1.04A 5i8fA-5usoA:
undetectable		 5i8fA-5usoA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuj ALKZ

(Streptomyces
sahachiroi) 		PF06224
(HTH_42) 		4 VAL A 253
ALA A   3
GLN A   7
VAL A   8
 None
 1.03A 5i8fA-5uujA:
undetectable		 5i8fA-5uujA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vu3 COMPETENCE
DAMAGE-INDUCIBLE
PROTEIN A

(Enterobacter
cloacae) 		PF02464
(CinA) 		4 VAL A 151
LYS A 154
ALA A 155
VAL A 127
 None
 0.88A 5i8fA-5vu3A:
undetectable		 5i8fA-5vu3A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8r 30S RIBOSOMAL
PROTEIN S9,
CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 4 VAL i 132
LYS i 133
ALA i 134
GLN i 142
 None
None
None
C  a1197 ( 3.4A)
 0.94A 5i8fA-5x8ri:
undetectable		 5i8fA-5x8ri:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c14 -

(-) 		no annotation 4 VAL A1289
LYS A1288
ALA A1287
VAL A1280
 None
 1.03A 5i8fA-6c14A:
undetectable		 5i8fA-6c14A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6de8 BIFUNCTIONAL PROTEIN
FOLD

(Campylobacter
jejuni) 		no annotation 4 VAL A  48
LYS A  51
ALA A  52
VAL A  64
 None
None
IOD  A 309 ( 4.7A)
IOD  A 309 ( 4.9A)
 0.56A 5i8fA-6de8A:
undetectable		 5i8fA-6de8A:
17.20