SIMILAR PATTERNS OF AMINO ACIDS FOR 5I75_A_68PA701_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c3c | PROTEIN(ADENYLOSUCCINATELYASE) (Thermotogamaritima) |
PF00206(Lyase_1)PF10397(ADSL_C) | 5 | GLY A 185GLY A 178LEU A 204GLY A 91VAL A 190 | None | 0.78A | 5i75A-1c3cA:0.1 | 5i75A-1c3cA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f5q | GAMMA HERPESVIRUSCYCLIN (Muridgammaherpesvirus4) |
PF00134(Cyclin_N) | 5 | ALA B 75PHE B 44LEU B 182GLY B 37VAL B 40 | None | 1.18A | 5i75A-1f5qB:0.0 | 5i75A-1f5qB:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f8f | BENZYL ALCOHOLDEHYDROGENASE (Acinetobactercalcoaceticus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 220GLY A 289GLY A 203LEU A 204GLY A 275 | NoneNAD A 375 ( 3.7A)NoneNoneNone | 1.06A | 5i75A-1f8fA:0.0 | 5i75A-1f8fA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h6d | PRECURSOR FORM OFGLUCOSE-FRUCTOSEOXIDOREDUCTASE (Zymomonasmobilis) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 5 | ILE A 99ALA A 95TYR A 94GLY A 105PHE A 103 | NoneNoneNDP A 500 (-3.4A)NoneNone | 0.92A | 5i75A-1h6dA:0.0 | 5i75A-1h6dA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hpg | GLUTAMIC ACIDSPECIFIC PROTEASE (Streptomycesgriseus) |
no annotation | 5 | ILE A 31ALA A 30SER A 40GLY A 86VAL A 106 | None | 1.19A | 5i75A-1hpgA:undetectable | 5i75A-1hpgA:17.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jji | CARBOXYLESTERASE (Archaeoglobusfulgidus) |
PF07859(Abhydrolase_3) | 5 | TYR A 16ILE A 36ALA A 35TYR A 32GLY A 88 | NoneNoneNoneNoneEPE A 455 (-3.7A) | 0.94A | 5i75A-1jjiA:0.0 | 5i75A-1jjiA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kp0 | CREATINEAMIDINOHYDROLASE (Actinobacillus) |
PF00557(Peptidase_M24)PF01321(Creatinase_N) | 5 | ILE A 184ALA A 181GLY A 242GLY A 187VAL A 239 | None | 0.96A | 5i75A-1kp0A:0.0 | 5i75A-1kp0A:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kp2 | ARGININOSUCCINATESYNTHETASE (Escherichiacoli) |
PF00764(Arginosuc_synth) | 5 | TYR A 142GLY A 333GLY A 110LEU A 113GLY A 133 | NoneNoneNoneNoneATP A 459 ( 4.4A) | 1.12A | 5i75A-1kp2A:0.0 | 5i75A-1kp2A:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mhs | PLASMA MEMBRANEATPASE (Neurosporacrassa) |
PF00122(E1-E2_ATPase)PF00690(Cation_ATPase_N)PF00702(Hydrolase) | 5 | ILE A 696GLY A 294GLY A 757LEU A 761GLY A 333 | None | 1.24A | 5i75A-1mhsA:0.0 | 5i75A-1mhsA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mq7 | DEOXYURIDINE5'-TRIPHOSPHATENUCLEOTIDOHYDROLASE (Mycobacteriumtuberculosis) |
PF00692(dUTPase) | 5 | ILE A 90ALA A 50GLY A 48GLY A 80VAL A 61 | None | 1.25A | 5i75A-1mq7A:undetectable | 5i75A-1mq7A:13.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pvd | PYRUVATEDECARBOXYLASE (Saccharomycescerevisiae) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ALA A 425GLY A 84GLY A 420GLY A 94VAL A 95 | None | 0.94A | 5i75A-1pvdA:0.0 | 5i75A-1pvdA:23.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qdl | PROTEIN(ANTHRANILATESYNTHASE(TRPG-SUBUNIT)) (Sulfolobussolfataricus) |
PF00117(GATase) | 5 | ILE B 17ALA B 18GLY B 54GLY B 82VAL B 83 | None | 1.17A | 5i75A-1qdlB:undetectable | 5i75A-1qdlB:15.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qwk | ALDO-KETO REDUCTASEFAMILY 1 MEMBER C1 (Caenorhabditiselegans) |
PF00248(Aldo_ket_red) | 5 | ILE A 260ALA A 259GLY A 20LEU A 45VAL A 276 | None | 1.20A | 5i75A-1qwkA:undetectable | 5i75A-1qwkA:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rkx | CDP-GLUCOSE-4,6-DEHYDRATASE (Yersiniapseudotuberculosis) |
PF16363(GDP_Man_Dehyd) | 5 | ILE A 118ALA A 117GLY A 185PHE A 176VAL A 188 | None | 1.13A | 5i75A-1rkxA:undetectable | 5i75A-1rkxA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sqj | OLIGOXYLOGLUCANREDUCING-END-SPECIFIC CELLOBIOHYDROLASE (Geotrichum sp.M128) |
PF15899(BNR_6) | 5 | ALA A 446SER A 467GLY A 462LEU A 448VAL A 9 | None | 1.23A | 5i75A-1sqjA:undetectable | 5i75A-1sqjA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ybw | HEPATOCYTE GROWTHFACTOR ACTIVATORPRECURSOR (Homo sapiens) |
PF00089(Trypsin) | 5 | ILE A 537ALA A 538GLY A 621SER A 598GLY A 585 | None | 1.08A | 5i75A-1ybwA:undetectable | 5i75A-1ybwA:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yr2 | PROLYLOLIGOPEPTIDASE (Novosphingobiumcapsulatum) |
PF00326(Peptidase_S9)PF02897(Peptidase_S9_N) | 5 | ASP A 590ILE A 571GLY A 555LEU A 558GLY A 582 | None | 1.10A | 5i75A-1yr2A:undetectable | 5i75A-1yr2A:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c1c | CARBOXYPEPTIDASE B (Helicoverpa zea) |
PF00246(Peptidase_M14) | 5 | ILE A 202TYR A 269GLY A 218GLY A 241GLY A 300 | None | 1.20A | 5i75A-2c1cA:undetectable | 5i75A-2c1cA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cjk | NUCLEARPOLYADENYLATEDRNA-BINDING PROTEIN4 (Saccharomycescerevisiae) |
PF00076(RRM_1) | 5 | ILE A 245ALA A 318GLY A 267GLY A 243VAL A 300 | None A B 2 ( 4.2A)NoneNoneNone | 1.08A | 5i75A-2cjkA:undetectable | 5i75A-2cjkA:14.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fcf | MULTIPLE PDZ DOMAINPROTEIN (Homo sapiens) |
PF00595(PDZ) | 5 | ILE A1228ALA A1224PHE A1237SER A1165VAL A1235 | None | 1.22A | 5i75A-2fcfA:undetectable | 5i75A-2fcfA:11.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hg4 | 6-DEOXYERYTHRONOLIDEB SYNTHASE (Saccharopolysporaerythraea) |
PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF08990(Docking)PF16197(KAsynt_C_assoc) | 5 | ILE A 738ALA A 681GLY A 679LEU A 721GLY A 559 | None | 1.19A | 5i75A-2hg4A:undetectable | 5i75A-2hg4A:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i14 | NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE (Pyrococcusfuriosus) |
PF01729(QRPTase_C)PF02749(QRPTase_N) | 5 | ILE A 136GLY A 158GLY A 164LEU A 163GLY A 289 | NoneNoneNoneNonePCP A 392 (-3.3A) | 1.17A | 5i75A-2i14A:undetectable | 5i75A-2i14A:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j6l | ALDEHYDEDEHYDROGENASE FAMILY7 MEMBER A1 (Homo sapiens) |
PF00171(Aldedh) | 5 | ILE A 164GLY A 162LEU A 189GLY A 252VAL A 255 | NAI A1501 (-4.4A)NoneNoneNoneNone | 1.22A | 5i75A-2j6lA:undetectable | 5i75A-2j6lA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j8w | CYTOCHROME C' (Rubrivivaxgelatinosus) |
PF01322(Cytochrom_C_2) | 5 | ILE A 19ALA A 15GLY A 116PHE A 89VAL A 93 | HEM A1129 (-4.9A)NoneNoneHEM A1129 (-3.9A)None | 1.21A | 5i75A-2j8wA:undetectable | 5i75A-2j8wA:13.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qm1 | GLUCOKINASE (Enterococcusfaecalis) |
PF00480(ROK) | 5 | ALA A 197GLY A 182PHE A 174SER A 188GLY A 192 | None | 1.08A | 5i75A-2qm1A:undetectable | 5i75A-2qm1A:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qo3 | ERYAII ERYTHROMYCINPOLYKETIDE SYNTHASEMODULES 3 AND 4 (Saccharopolysporaerythraea) |
PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | ILE A 747ALA A 690GLY A 688LEU A 730GLY A 567 | None | 1.19A | 5i75A-2qo3A:undetectable | 5i75A-2qo3A:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qpq | PROTEIN BUG27 (Bordetellapertussis) |
PF03401(TctC) | 5 | TYR A 268GLY A 21GLY A 267LEU A 209GLY A 166 | NoneCIT A 302 (-3.7A)NoneNoneNone | 1.23A | 5i75A-2qpqA:undetectable | 5i75A-2qpqA:18.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wge | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 1 (Mycobacteriumtuberculosis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | ALA A 209GLY A 61PHE A 239LEU A 205GLY A 236 | NoneNoneGOL A1421 (-4.2A)NoneNone | 0.92A | 5i75A-2wgeA:undetectable | 5i75A-2wgeA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y8u | CHITIN DEACETYLASE (Aspergillusnidulans) |
PF01522(Polysacc_deac_1) | 5 | ILE A 42ALA A 221PHE A 182LEU A 211GLY A 189 | None | 1.24A | 5i75A-2y8uA:undetectable | 5i75A-2y8uA:17.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yij | PHOSPHOLIPASEA1-IIGAMMA (Arabidopsisthaliana) |
PF01764(Lipase_3) | 5 | ILE A 232ALA A 269GLY A 131GLY A 234VAL A 212 | None | 1.06A | 5i75A-2yijA:undetectable | 5i75A-2yijA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3agr | NUCLEOSIDETRIPHOSPHATEHYDROLASE (Neosporacaninum) |
PF01150(GDA1_CD39) | 5 | ILE A 42ALA A 41GLY A 577LEU A 79VAL A 583 | None | 1.17A | 5i75A-3agrA:undetectable | 5i75A-3agrA:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ayd | GALECTIN-3 (Homo sapiens) |
PF00337(Gal-bind_lectin) | 5 | ASP A 215ILE A 200PHE A 192LEU A 219GLY A 136 | None | 1.12A | 5i75A-3aydA:undetectable | 5i75A-3aydA:11.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ce9 | GLYCEROLDEHYDROGENASE (Clostridiumacetobutylicum) |
PF13685(Fe-ADH_2) | 5 | ILE A 268GLY A 296PHE A 297GLY A 170GLY A 303 | None | 1.01A | 5i75A-3ce9A:undetectable | 5i75A-3ce9A:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmt | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | ILE A 49ALA A 50SER A 41GLY A 54VAL A 323 | None | 1.21A | 5i75A-3cmtA:undetectable | 5i75A-3cmtA:15.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmt | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | ILE A4049ALA A4050SER A4041GLY A4054VAL A4323 | None | 1.20A | 5i75A-3cmtA:undetectable | 5i75A-3cmtA:15.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | ILE A5049ALA A5050SER A5041GLY A5054VAL A5323 | None | 1.15A | 5i75A-3cmuA:undetectable | 5i75A-3cmuA:13.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmv | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | ILE A2049ALA A2050SER A2041GLY A2054VAL A2323 | None | 1.25A | 5i75A-3cmvA:undetectable | 5i75A-3cmvA:17.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cpg | UNCHARACTERIZEDPROTEIN (Bifidobacteriumadolescentis) |
PF01168(Ala_racemase_N) | 5 | ASP A 237ALA A 187GLY A 200LEU A 201GLY A 195 | None | 1.01A | 5i75A-3cpgA:undetectable | 5i75A-3cpgA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dqz | ALPHA-HYDROXYNITRILELYASE-LIKE PROTEIN (Arabidopsisthaliana) |
PF12697(Abhydrolase_6) | 5 | ILE A 253ALA A 254TYR A 257GLY A 79VAL A 203 | None | 1.04A | 5i75A-3dqzA:undetectable | 5i75A-3dqzA:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ec2 | DNA REPLICATIONPROTEIN DNAC (Aquifexaeolicus) |
PF01695(IstB_IS21) | 5 | ASP A 198TYR A 212GLY A 151SER A 201GLY A 204 | None | 1.21A | 5i75A-3ec2A:undetectable | 5i75A-3ec2A:15.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ecq | ENDO-ALPHA-N-ACETYLGALACTOSAMINIDASE (Streptococcuspneumoniae) |
PF12905(Glyco_hydro_101)PF17451(Glyco_hyd_101C) | 5 | ILE A 824ALA A 839GLY A 522GLY A 798GLY A 480 | None | 1.22A | 5i75A-3ecqA:undetectable | 5i75A-3ecqA:16.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gkf | ALDOLASE LSRF (Escherichiacoli) |
no annotation | 5 | GLY O 110PHE O 61GLY O 59LEU O 68GLY O 175 | None | 1.07A | 5i75A-3gkfO:undetectable | 5i75A-3gkfO:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gs3 | SYMPLEKIN (Drosophilamelanogaster) |
PF11935(DUF3453) | 5 | ILE A 105ALA A 151GLY A 134LEU A 138VAL A 90 | None | 1.04A | 5i75A-3gs3A:undetectable | 5i75A-3gs3A:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h32 | FIBRINOGEN ALPHACHAINFIBRINOGEN BETACHAIN (Homo sapiens) |
PF00147(Fibrinogen_C)PF08702(Fib_alpha) | 5 | GLY B 263PHE B 262SER A 160GLY B 258GLY B 272 | None | 1.05A | 5i75A-3h32B:undetectable | 5i75A-3h32B:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i93 | DEOXYURIDINE5'-TRIPHOSPHATENUCLEOTIDOHYDROLASE (Mycobacteriumtuberculosis) |
PF00692(dUTPase) | 5 | ILE A 90ALA A 50GLY A 48GLY A 80VAL A 61 | DUP A 201 (-4.7A)NoneNoneDUP A 201 (-3.4A)DUP A 201 ( 4.8A) | 1.24A | 5i75A-3i93A:undetectable | 5i75A-3i93A:14.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iau | THREONINE DEAMINASE (Solanumlycopersicum) |
PF00291(PALP) | 5 | ILE A 342ALA A 343GLY A 220GLY A 199VAL A 225 | NoneNoneLLP A 91 ( 3.4A)NoneNone | 1.20A | 5i75A-3iauA:undetectable | 5i75A-3iauA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l4e | UNCHARACTERIZEDPEPTIDASE LMO0363 (Listeriamonocytogenes) |
PF03575(Peptidase_S51) | 5 | ASP A 136ILE A 124ALA A 149GLY A 117VAL A 84 | SO4 A 207 ( 4.8A)NoneNoneNoneNone | 0.96A | 5i75A-3l4eA:undetectable | 5i75A-3l4eA:16.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3moj | ATP-DEPENDENT RNAHELICASE DBPA (Bacillussubtilis) |
PF03880(DbpA) | 5 | ILE B 416GLY B 423PHE B 421GLY B 469VAL B 467 | None U A2554 ( 3.5A)None C A2556 ( 3.1A) U A2555 ( 3.9A) | 0.98A | 5i75A-3mojB:undetectable | 5i75A-3mojB:9.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nbu | GLUCOSE-6-PHOSPHATEISOMERASE (Escherichiacoli) |
PF00342(PGI) | 5 | ILE A 486ALA A 487GLY A 296GLY A 161VAL A 165 | None | 1.18A | 5i75A-3nbuA:undetectable | 5i75A-3nbuA:21.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nbu | GLUCOSE-6-PHOSPHATEISOMERASE (Escherichiacoli) |
PF00342(PGI) | 5 | ILE A 486ALA A 487PHE A 345SER A 481GLY A 161 | None | 1.10A | 5i75A-3nbuA:undetectable | 5i75A-3nbuA:21.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nfb | BETA-PEPTIDYLAMINOPEPTIDASE (Sphingosinicellaxenopeptidilytica) |
PF03576(Peptidase_S58) | 5 | ILE A 73GLY A 209GLY A 289GLY A 278VAL A 277 | NoneNoneOAE A 376 ( 4.5A)NoneNone | 0.96A | 5i75A-3nfbA:undetectable | 5i75A-3nfbA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o7q | L-FUCOSE-PROTONSYMPORTER (Escherichiacoli) |
PF07690(MFS_1) | 5 | ILE A 257ALA A 255GLY A 377SER A 250GLY A 372 | None | 1.24A | 5i75A-3o7qA:undetectable | 5i75A-3o7qA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p5p | TAXADIENE SYNTHASE (Taxusbrevifolia) |
PF01397(Terpene_synth)PF03936(Terpene_synth_C) | 5 | TYR A 684TYR A 835SER A 713GLY A 715LEU A 716 | NoneA3C A 912 ( 4.4A)NoneA3C A 911 ( 4.7A)None | 1.20A | 5i75A-3p5pA:2.2 | 5i75A-3p5pA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pqv | RCL1 PROTEIN (Kluyveromyceslactis) |
PF01137(RTC)PF05189(RTC_insert) | 5 | ALA A 127GLY A 192GLY A 135LEU A 136GLY A 241 | NonePEG A 410 ( 4.8A)NoneNoneNone | 1.24A | 5i75A-3pqvA:undetectable | 5i75A-3pqvA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q2k | OXIDOREDUCTASE (Bordetellapertussis) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 5 | ILE A 335ALA A 334SER A 328LEU A 347GLY A 223 | None | 1.05A | 5i75A-3q2kA:undetectable | 5i75A-3q2kA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qvf | FOMA PROTEIN (Streptomyceswedmorensis) |
PF00696(AA_kinase) | 5 | ILE A 50GLY A 12SER A 148GLY A 134LEU A 102 | NoneFV1 A4001 ( 3.3A)FV1 A4001 (-2.6A)FV1 A4001 ( 4.0A)None | 1.03A | 5i75A-3qvfA:undetectable | 5i75A-3qvfA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tj0 | NUCLEOPROTEIN (Influenza Bvirus) |
PF00506(Flu_NP) | 5 | ILE A 342SER A 337GLY A 87LEU A 86GLY A 346 | None | 1.18A | 5i75A-3tj0A:undetectable | 5i75A-3tj0A:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ua4 | PROTEIN ARGININEN-METHYLTRANSFERASE5 (Caenorhabditiselegans) |
PF05185(PRMT5)PF17285(PRMT5_TIM)PF17286(PRMT5_C) | 5 | ILE A 183GLY A 232PHE A 235GLY A 228VAL A 192 | None | 1.13A | 5i75A-3ua4A:undetectable | 5i75A-3ua4A:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ujz | METALLOPROTEASE STCE (Escherichiacoli) |
PF10462(Peptidase_M66) | 5 | TYR A 713ALA A 387PHE A 551GLY A 714VAL A 406 | None | 1.18A | 5i75A-3ujzA:undetectable | 5i75A-3ujzA:18.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w9i | MULTIDRUG RESISTANCEPROTEIN MEXB (Pseudomonasaeruginosa) |
PF00873(ACR_tran) | 5 | ILE A1001ALA A1000GLY A 983GLY A 397VAL A 399 | None | 1.09A | 5i75A-3w9iA:1.8 | 5i75A-3w9iA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zwf | ZINCPHOSPHODIESTERASEELAC PROTEIN 1 (Homo sapiens) |
PF00753(Lactamase_B)PF12706(Lactamase_B_2) | 5 | ASP A 253ILE A 60SER A 186LEU A 123GLY A 70 | ZN A1363 (-2.5A)NoneNoneNoneNone | 0.89A | 5i75A-3zwfA:undetectable | 5i75A-3zwfA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a9a | RIBOSOME-INTERACTINGGTPASE 1 (Saccharomycescerevisiae) |
PF01926(MMR_HSR1)PF02824(TGS)PF16897(MMR_HSR1_Xtn) | 5 | ALA A 140GLY A 105SER A 67GLY A 69LEU A 146 | None | 1.06A | 5i75A-4a9aA:3.7 | 5i75A-4a9aA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aej | COLLAGENALPHA-1(III) CHAIN (Homo sapiens) |
PF01410(COLFI) | 5 | ILE A 223ALA A 224PHE A 117GLY A 108VAL A 239 | None | 1.09A | 5i75A-4aejA:undetectable | 5i75A-4aejA:17.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cql | ESTRADIOL17-BETA-DEHYDROGENASE 8 (Homo sapiens) |
PF13561(adh_short_C2) | 5 | ALA A 40GLY A 105SER A 21GLY A 24VAL A 76 | NoneNAD A 301 (-3.5A)NAD A 301 (-3.1A)NoneNAD A 301 (-3.6A) | 1.20A | 5i75A-4cqlA:undetectable | 5i75A-4cqlA:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hea | NADH-QUINONEOXIDOREDUCTASESUBUNIT 14 (Thermusthermophilus) |
PF00361(Proton_antipo_M) | 5 | ALA N 372GLY N 335LEU N 336GLY N 244VAL N 241 | None | 1.06A | 5i75A-4heaN:2.4 | 5i75A-4heaN:25.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hea | NADH-QUINONEOXIDOREDUCTASESUBUNIT 14 (Thermusthermophilus) |
PF00361(Proton_antipo_M) | 5 | ALA N 372TYR N 374GLY N 335LEU N 336GLY N 244 | None | 1.00A | 5i75A-4heaN:2.4 | 5i75A-4heaN:25.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4imi | SYMPLEKIN (Drosophilamelanogaster) |
PF11935(DUF3453) | 5 | ILE A 105ALA A 151GLY A 134LEU A 138VAL A 90 | None | 0.99A | 5i75A-4imiA:undetectable | 5i75A-4imiA:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nuh | ICE-BINDING PROTEIN (Leucosporidium) |
PF11999(DUF3494) | 5 | ALA A 65GLY A 36GLY A 63GLY A 54VAL A 52 | None | 0.96A | 5i75A-4nuhA:undetectable | 5i75A-4nuhA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r9g | MBP1 (Caldanaerobiuspolysaccharolyticus) |
PF13416(SBP_bac_8) | 5 | ASP A 305ILE A 344ALA A 345GLY A 270VAL A 365 | BMA A 502 ( 4.7A)NoneNoneNoneNone | 1.09A | 5i75A-4r9gA:undetectable | 5i75A-4r9gA:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wmj | GLUCOSE-6-PHOSPHATEISOMERASE (Coliaseurytheme) |
PF00342(PGI) | 5 | ILE A 494ALA A 495GLY A 302GLY A 167VAL A 171 | None | 1.21A | 5i75A-4wmjA:undetectable | 5i75A-4wmjA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wut | ABC TRANSPORTERSUBSTRATE BINDINGPROTEIN (RIBOSE) (Agrobacteriumvitis) |
PF13407(Peripla_BP_4) | 5 | ILE A 215ALA A 241GLY A 187GLY A 217VAL A 205 | None | 1.04A | 5i75A-4wutA:undetectable | 5i75A-4wutA:20.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xnu | INTEGRAL MEMBRANEPROTEIN-DOPAMINETRANSPORTER (Drosophilamelanogaster) |
PF00209(SNF) | 6 | ASP A 46TYR A 123GLY A 322SER A 421GLY A 425GLY A 480 | 41U A 605 ( 3.3A)None41U A 605 ( 4.1A) NA A 602 ( 2.4A)41U A 605 ( 3.7A)None | 0.31A | 5i75A-4xnuA:54.5 | 5i75A-4xnuA:53.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y4q | SORTASE, SRTB FAMILY (Streptococcuspneumoniae) |
PF04203(Sortase) | 5 | ILE A 99TYR A 101PHE A 161LEU A 184GLY A 156 | None | 1.15A | 5i75A-4y4qA:undetectable | 5i75A-4y4qA:17.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z3y | BENZOYL-COAREDUCTASE, PUTATIVE (Geobactermetallireducens) |
PF01314(AFOR_C)PF02730(AFOR_N) | 5 | TYR A 546GLY A 96GLY A 65LEU A 66GLY A 536 | NoneMTE A 702 (-3.0A)NoneNoneSF4 A 701 ( 4.3A) | 1.25A | 5i75A-4z3yA:0.5 | 5i75A-4z3yA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5azd | BACTERIORHODOPSIN (Thermusthermophilus) |
PF01036(Bac_rhodopsin) | 5 | ILE A 174ALA A 173LEU A 121GLY A 180VAL A 183 | None | 1.25A | 5i75A-5azdA:1.3 | 5i75A-5azdA:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5db4 | NICOTINATE-NUCLEOTIDEADENYLYLTRANSFERASE (Mycobacteroidesabscessus) |
PF01467(CTP_transf_like) | 5 | ILE A 108GLY A 21SER A 136GLY A 110LEU A 114 | NoneATP A 301 (-3.7A)NoneATP A 301 (-3.0A)None | 0.75A | 5i75A-5db4A:undetectable | 5i75A-5db4A:17.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ex8 | CYTOCHROME P450 (Streptomycestoyocaensis) |
PF00067(p450) | 5 | ILE A 217ALA A 216GLY A 210GLY A 83VAL A 225 | None | 1.11A | 5i75A-5ex8A:2.0 | 5i75A-5ex8A:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5exr | DNA PRIMASE LARGESUBUNIT (Homo sapiens) |
PF04104(DNA_primase_lrg) | 5 | ASP B 361ILE B 349GLY B 310LEU B 313GLY B 344 | None | 1.18A | 5i75A-5exrB:undetectable | 5i75A-5exrB:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h9p | GALECTIN-3 (Homo sapiens) |
PF00337(Gal-bind_lectin) | 5 | ASP A 215ILE A 200PHE A 192LEU A 219GLY A 136 | None | 1.10A | 5i75A-5h9pA:undetectable | 5i75A-5h9pA:13.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i47 | RIMK DOMAIN PROTEINATP-GRASP (Sphaerobacterthermophilus) |
PF08443(RimK) | 5 | ILE A 268ALA A 265GLY A 274GLY A 230VAL A 77 | None | 1.10A | 5i75A-5i47A:undetectable | 5i75A-5i47A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i51 | TRANSKETOLASE (Scheffersomycesstipitis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | ILE A 512ALA A 511SER A 505LEU A 521VAL A 370 | None | 1.23A | 5i75A-5i51A:undetectable | 5i75A-5i51A:22.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5i6z | SODIUM-DEPENDENTSEROTONINTRANSPORTER (Homo sapiens) |
PF00209(SNF) | 12 | TYR A 95ASP A 98ILE A 172ALA A 173TYR A 175GLY A 338PHE A 341SER A 438GLY A 442LEU A 443GLY A 498VAL A 501 | None | 0.40A | 5i75A-5i6zA:61.1 | 5i75A-5i6zA:99.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jij | ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE (Mycolicibacteriumthermoresistibile) |
PF00982(Glyco_transf_20) | 5 | GLY A 203PHE A 207LEU A 214GLY A 231VAL A 242 | None | 1.21A | 5i75A-5jijA:undetectable | 5i75A-5jijA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kgn | 2,3-BISPHOSPHOGLYCERATE-INDEPENDENTPHOSPHOGLYCERATEMUTASE (Caenorhabditiselegans) |
PF01676(Metalloenzyme)PF06415(iPGM_N) | 5 | ILE A 291ALA A 213GLY A 317GLY A 139GLY A 296 | None | 1.08A | 5i75A-5kgnA:undetectable | 5i75A-5kgnA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kgn | 2,3-BISPHOSPHOGLYCERATE-INDEPENDENTPHOSPHOGLYCERATEMUTASE (Caenorhabditiselegans) |
PF01676(Metalloenzyme)PF06415(iPGM_N) | 5 | ILE A 291ALA A 213GLY A 317PHE A 280GLY A 139 | None | 1.20A | 5i75A-5kgnA:undetectable | 5i75A-5kgnA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ks8 | PYRUVATE CARBOXYLASESUBUNIT ALPHA (Methylobacillusflagellatus) |
PF00289(Biotin_carb_N)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 5 | ASP A 36SER A 33GLY A 58LEU A 57GLY A 80 | None | 1.21A | 5i75A-5ks8A:undetectable | 5i75A-5ks8A:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kzm | TRYPTOPHAN SYNTHASEALPHA CHAIN (Francisellatularensis) |
PF00290(Trp_syntA) | 5 | GLY A 173GLY A 99LEU A 51GLY A 231VAL A 210 | None | 0.85A | 5i75A-5kzmA:undetectable | 5i75A-5kzmA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kzm | TRYPTOPHAN SYNTHASEALPHA CHAIN (Francisellatularensis) |
PF00290(Trp_syntA) | 5 | ILE A 21GLY A 173GLY A 99LEU A 51VAL A 210 | None | 0.79A | 5i75A-5kzmA:undetectable | 5i75A-5kzmA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mrt | LYTIC ENDOPEPTIDASEPREPROENZYME (Lysobacter sp.XL1) |
no annotation | 5 | ALA A 36GLY A 150LEU A 163GLY A 56VAL A 48 | NoneNoneNoneFMT A 303 ( 4.4A)None | 1.25A | 5i75A-5mrtA:undetectable | 5i75A-5mrtA:8.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nfb | GALECTIN-3 (Homo sapiens) |
PF00337(Gal-bind_lectin) | 5 | ASP A 215ILE A 200PHE A 192LEU A 219GLY A 136 | None | 1.05A | 5i75A-5nfbA:undetectable | 5i75A-5nfbA:14.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ntf | AMINOPEPTIDASE (Trypanosomacruzi) |
PF00883(Peptidase_M17) | 5 | ALA A 399GLY A 295GLY A 373LEU A 377GLY A 307 | NoneNoneSO4 A 601 (-3.0A)NoneNone | 0.89A | 5i75A-5ntfA:undetectable | 5i75A-5ntfA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nth | PUTATIVEAMINOPEPTIDASE (Leishmaniamajor) |
PF00883(Peptidase_M17) | 5 | ILE A 394TYR A 369GLY A 493PHE A 496GLY A 397 | None | 1.24A | 5i75A-5nthA:undetectable | 5i75A-5nthA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u1o | GLUTATHIONEREDUCTASE (Vibrioparahaemolyticus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ILE A 99GLY A 50SER A 18GLY A 43LEU A 42 | NoneFAD A 501 (-3.4A)FAD A 501 (-3.4A)NoneNone | 1.06A | 5i75A-5u1oA:2.8 | 5i75A-5u1oA:21.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5us8 | ARGININOSUCCINATESYNTHASE (Bordetellapertussis) |
PF00764(Arginosuc_synth) | 5 | TYR A 143GLY A 334GLY A 111LEU A 114GLY A 134 | None | 1.13A | 5i75A-5us8A:undetectable | 5i75A-5us8A:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5usd | PEPTIDASE S66 (Bacillusanthracis) |
PF02016(Peptidase_S66) | 5 | ILE A 113PHE A 107SER A 16LEU A 91GLY A 131 | None | 1.18A | 5i75A-5usdA:undetectable | 5i75A-5usdA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v36 | GLUTATHIONEREDUCTASE (Streptococcusmutans) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ILE A 178ALA A 179GLY A 141GLY A 262GLY A 46 | FAD A 501 ( 4.1A)NoneNone CL A 505 (-3.4A)FAD A 501 ( 3.7A) | 1.02A | 5i75A-5v36A:0.5 | 5i75A-5v36A:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v3s | TWO-COMPONENTINSECTICIDAL PROTEIN16 KDA UNIT (Alcaligenesfaecalis) |
PF06355(Aegerolysin) | 5 | TYR A 100ASP A 111GLY A 85LEU A 38GLY A 107 | None | 1.13A | 5i75A-5v3sA:undetectable | 5i75A-5v3sA:13.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6aph | ADENOSYLHOMOCYSTEINASE (Elizabethkingiaanophelis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | ILE A 208ALA A 207GLY A 241PHE A 237VAL A 221 | None | 1.19A | 5i75A-6aphA:undetectable | 5i75A-6aphA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bzc | GLUCOSE-6-PHOSPHATEISOMERASE (Elizabethkingiaanophelis) |
no annotation | 5 | ILE A 485ALA A 486GLY A 295GLY A 161VAL A 165 | None | 1.20A | 5i75A-6bzcA:undetectable | 5i75A-6bzcA:10.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d0n | CLC-TYPEFLUORIDE/PROTONANTIPORTER (Enterococcuscasseliflavus) |
no annotation | 5 | GLY A 330SER A 296LEU A 301GLY A 230VAL A 352 | None | 1.05A | 5i75A-6d0nA:undetectable | 5i75A-6d0nA:9.62 |