SIMILAR PATTERNS OF AMINO ACIDS FOR 5I75_A_68PA701

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)


(Thermotoga
maritima)
PF00206
(Lyase_1)
PF10397
(ADSL_C)
5 GLY A 185
GLY A 178
LEU A 204
GLY A  91
VAL A 190
None
0.78A 5i75A-1c3cA:
0.1
5i75A-1c3cA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5q GAMMA HERPESVIRUS
CYCLIN


(Murid
gammaherpesvirus
4)
PF00134
(Cyclin_N)
5 ALA B  75
PHE B  44
LEU B 182
GLY B  37
VAL B  40
None
1.18A 5i75A-1f5qB:
0.0
5i75A-1f5qB:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8f BENZYL ALCOHOL
DEHYDROGENASE


(Acinetobacter
calcoaceticus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A 220
GLY A 289
GLY A 203
LEU A 204
GLY A 275
None
NAD  A 375 ( 3.7A)
None
None
None
1.06A 5i75A-1f8fA:
0.0
5i75A-1f8fA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6d PRECURSOR FORM OF
GLUCOSE-FRUCTOSE
OXIDOREDUCTASE


(Zymomonas
mobilis)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
5 ILE A  99
ALA A  95
TYR A  94
GLY A 105
PHE A 103
None
None
NDP  A 500 (-3.4A)
None
None
0.92A 5i75A-1h6dA:
0.0
5i75A-1h6dA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpg GLUTAMIC ACID
SPECIFIC PROTEASE


(Streptomyces
griseus)
no annotation 5 ILE A  31
ALA A  30
SER A  40
GLY A  86
VAL A 106
None
1.19A 5i75A-1hpgA:
undetectable
5i75A-1hpgA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jji CARBOXYLESTERASE

(Archaeoglobus
fulgidus)
PF07859
(Abhydrolase_3)
5 TYR A  16
ILE A  36
ALA A  35
TYR A  32
GLY A  88
None
None
None
None
EPE  A 455 (-3.7A)
0.94A 5i75A-1jjiA:
0.0
5i75A-1jjiA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp0 CREATINE
AMIDINOHYDROLASE


(Actinobacillus)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
5 ILE A 184
ALA A 181
GLY A 242
GLY A 187
VAL A 239
None
0.96A 5i75A-1kp0A:
0.0
5i75A-1kp0A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp2 ARGININOSUCCINATE
SYNTHETASE


(Escherichia
coli)
PF00764
(Arginosuc_synth)
5 TYR A 142
GLY A 333
GLY A 110
LEU A 113
GLY A 133
None
None
None
None
ATP  A 459 ( 4.4A)
1.12A 5i75A-1kp2A:
0.0
5i75A-1kp2A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhs PLASMA MEMBRANE
ATPASE


(Neurospora
crassa)
PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase)
5 ILE A 696
GLY A 294
GLY A 757
LEU A 761
GLY A 333
None
1.24A 5i75A-1mhsA:
0.0
5i75A-1mhsA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mq7 DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE


(Mycobacterium
tuberculosis)
PF00692
(dUTPase)
5 ILE A  90
ALA A  50
GLY A  48
GLY A  80
VAL A  61
None
1.25A 5i75A-1mq7A:
undetectable
5i75A-1mq7A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvd PYRUVATE
DECARBOXYLASE


(Saccharomyces
cerevisiae)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 ALA A 425
GLY A  84
GLY A 420
GLY A  94
VAL A  95
None
0.94A 5i75A-1pvdA:
0.0
5i75A-1pvdA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))


(Sulfolobus
solfataricus)
PF00117
(GATase)
5 ILE B  17
ALA B  18
GLY B  54
GLY B  82
VAL B  83
None
1.17A 5i75A-1qdlB:
undetectable
5i75A-1qdlB:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1


(Caenorhabditis
elegans)
PF00248
(Aldo_ket_red)
5 ILE A 260
ALA A 259
GLY A  20
LEU A  45
VAL A 276
None
1.20A 5i75A-1qwkA:
undetectable
5i75A-1qwkA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkx CDP-GLUCOSE-4,6-DEHY
DRATASE


(Yersinia
pseudotuberculosis)
PF16363
(GDP_Man_Dehyd)
5 ILE A 118
ALA A 117
GLY A 185
PHE A 176
VAL A 188
None
1.13A 5i75A-1rkxA:
undetectable
5i75A-1rkxA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqj OLIGOXYLOGLUCAN
REDUCING-END-SPECIFI
C CELLOBIOHYDROLASE


(Geotrichum sp.
M128)
PF15899
(BNR_6)
5 ALA A 446
SER A 467
GLY A 462
LEU A 448
VAL A   9
None
1.23A 5i75A-1sqjA:
undetectable
5i75A-1sqjA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR


(Homo sapiens)
PF00089
(Trypsin)
5 ILE A 537
ALA A 538
GLY A 621
SER A 598
GLY A 585
None
1.08A 5i75A-1ybwA:
undetectable
5i75A-1ybwA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE


(Novosphingobium
capsulatum)
PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N)
5 ASP A 590
ILE A 571
GLY A 555
LEU A 558
GLY A 582
None
1.10A 5i75A-1yr2A:
undetectable
5i75A-1yr2A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1c CARBOXYPEPTIDASE B

(Helicoverpa zea)
PF00246
(Peptidase_M14)
5 ILE A 202
TYR A 269
GLY A 218
GLY A 241
GLY A 300
None
1.20A 5i75A-2c1cA:
undetectable
5i75A-2c1cA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjk NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
4


(Saccharomyces
cerevisiae)
PF00076
(RRM_1)
5 ILE A 245
ALA A 318
GLY A 267
GLY A 243
VAL A 300
None
A  B   2 ( 4.2A)
None
None
None
1.08A 5i75A-2cjkA:
undetectable
5i75A-2cjkA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcf MULTIPLE PDZ DOMAIN
PROTEIN


(Homo sapiens)
PF00595
(PDZ)
5 ILE A1228
ALA A1224
PHE A1237
SER A1165
VAL A1235
None
1.22A 5i75A-2fcfA:
undetectable
5i75A-2fcfA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE


(Saccharopolyspora
erythraea)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc)
5 ILE A 738
ALA A 681
GLY A 679
LEU A 721
GLY A 559
None
1.19A 5i75A-2hg4A:
undetectable
5i75A-2hg4A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE


(Pyrococcus
furiosus)
PF01729
(QRPTase_C)
PF02749
(QRPTase_N)
5 ILE A 136
GLY A 158
GLY A 164
LEU A 163
GLY A 289
None
None
None
None
PCP  A 392 (-3.3A)
1.17A 5i75A-2i14A:
undetectable
5i75A-2i14A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1


(Homo sapiens)
PF00171
(Aldedh)
5 ILE A 164
GLY A 162
LEU A 189
GLY A 252
VAL A 255
NAI  A1501 (-4.4A)
None
None
None
None
1.22A 5i75A-2j6lA:
undetectable
5i75A-2j6lA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8w CYTOCHROME C'

(Rubrivivax
gelatinosus)
PF01322
(Cytochrom_C_2)
5 ILE A  19
ALA A  15
GLY A 116
PHE A  89
VAL A  93
HEM  A1129 (-4.9A)
None
None
HEM  A1129 (-3.9A)
None
1.21A 5i75A-2j8wA:
undetectable
5i75A-2j8wA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm1 GLUCOKINASE

(Enterococcus
faecalis)
PF00480
(ROK)
5 ALA A 197
GLY A 182
PHE A 174
SER A 188
GLY A 192
None
1.08A 5i75A-2qm1A:
undetectable
5i75A-2qm1A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4


(Saccharopolyspora
erythraea)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 ILE A 747
ALA A 690
GLY A 688
LEU A 730
GLY A 567
None
1.19A 5i75A-2qo3A:
undetectable
5i75A-2qo3A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpq PROTEIN BUG27

(Bordetella
pertussis)
PF03401
(TctC)
5 TYR A 268
GLY A  21
GLY A 267
LEU A 209
GLY A 166
None
CIT  A 302 (-3.7A)
None
None
None
1.23A 5i75A-2qpqA:
undetectable
5i75A-2qpqA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1


(Mycobacterium
tuberculosis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 ALA A 209
GLY A  61
PHE A 239
LEU A 205
GLY A 236
None
None
GOL  A1421 (-4.2A)
None
None
0.92A 5i75A-2wgeA:
undetectable
5i75A-2wgeA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8u CHITIN DEACETYLASE

(Aspergillus
nidulans)
PF01522
(Polysacc_deac_1)
5 ILE A  42
ALA A 221
PHE A 182
LEU A 211
GLY A 189
None
1.24A 5i75A-2y8uA:
undetectable
5i75A-2y8uA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yij PHOSPHOLIPASE
A1-IIGAMMA


(Arabidopsis
thaliana)
PF01764
(Lipase_3)
5 ILE A 232
ALA A 269
GLY A 131
GLY A 234
VAL A 212
None
1.06A 5i75A-2yijA:
undetectable
5i75A-2yijA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agr NUCLEOSIDE
TRIPHOSPHATE
HYDROLASE


(Neospora
caninum)
PF01150
(GDA1_CD39)
5 ILE A  42
ALA A  41
GLY A 577
LEU A  79
VAL A 583
None
1.17A 5i75A-3agrA:
undetectable
5i75A-3agrA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayd GALECTIN-3

(Homo sapiens)
PF00337
(Gal-bind_lectin)
5 ASP A 215
ILE A 200
PHE A 192
LEU A 219
GLY A 136
None
1.12A 5i75A-3aydA:
undetectable
5i75A-3aydA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce9 GLYCEROL
DEHYDROGENASE


(Clostridium
acetobutylicum)
PF13685
(Fe-ADH_2)
5 ILE A 268
GLY A 296
PHE A 297
GLY A 170
GLY A 303
None
1.01A 5i75A-3ce9A:
undetectable
5i75A-3ce9A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 ILE A  49
ALA A  50
SER A  41
GLY A  54
VAL A 323
None
1.21A 5i75A-3cmtA:
undetectable
5i75A-3cmtA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 ILE A4049
ALA A4050
SER A4041
GLY A4054
VAL A4323
None
1.20A 5i75A-3cmtA:
undetectable
5i75A-3cmtA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 ILE A5049
ALA A5050
SER A5041
GLY A5054
VAL A5323
None
1.15A 5i75A-3cmuA:
undetectable
5i75A-3cmuA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 ILE A2049
ALA A2050
SER A2041
GLY A2054
VAL A2323
None
1.25A 5i75A-3cmvA:
undetectable
5i75A-3cmvA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpg UNCHARACTERIZED
PROTEIN


(Bifidobacterium
adolescentis)
PF01168
(Ala_racemase_N)
5 ASP A 237
ALA A 187
GLY A 200
LEU A 201
GLY A 195
None
1.01A 5i75A-3cpgA:
undetectable
5i75A-3cpgA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN


(Arabidopsis
thaliana)
PF12697
(Abhydrolase_6)
5 ILE A 253
ALA A 254
TYR A 257
GLY A  79
VAL A 203
None
1.04A 5i75A-3dqzA:
undetectable
5i75A-3dqzA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec2 DNA REPLICATION
PROTEIN DNAC


(Aquifex
aeolicus)
PF01695
(IstB_IS21)
5 ASP A 198
TYR A 212
GLY A 151
SER A 201
GLY A 204
None
1.21A 5i75A-3ec2A:
undetectable
5i75A-3ec2A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE


(Streptococcus
pneumoniae)
PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C)
5 ILE A 824
ALA A 839
GLY A 522
GLY A 798
GLY A 480
None
1.22A 5i75A-3ecqA:
undetectable
5i75A-3ecqA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkf ALDOLASE LSRF

(Escherichia
coli)
no annotation 5 GLY O 110
PHE O  61
GLY O  59
LEU O  68
GLY O 175
None
1.07A 5i75A-3gkfO:
undetectable
5i75A-3gkfO:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs3 SYMPLEKIN

(Drosophila
melanogaster)
PF11935
(DUF3453)
5 ILE A 105
ALA A 151
GLY A 134
LEU A 138
VAL A  90
None
1.04A 5i75A-3gs3A:
undetectable
5i75A-3gs3A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h32 FIBRINOGEN ALPHA
CHAIN
FIBRINOGEN BETA
CHAIN


(Homo sapiens)
PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha)
5 GLY B 263
PHE B 262
SER A 160
GLY B 258
GLY B 272
None
1.05A 5i75A-3h32B:
undetectable
5i75A-3h32B:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i93 DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE


(Mycobacterium
tuberculosis)
PF00692
(dUTPase)
5 ILE A  90
ALA A  50
GLY A  48
GLY A  80
VAL A  61
DUP  A 201 (-4.7A)
None
None
DUP  A 201 (-3.4A)
DUP  A 201 ( 4.8A)
1.24A 5i75A-3i93A:
undetectable
5i75A-3i93A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iau THREONINE DEAMINASE

(Solanum
lycopersicum)
PF00291
(PALP)
5 ILE A 342
ALA A 343
GLY A 220
GLY A 199
VAL A 225
None
None
LLP  A  91 ( 3.4A)
None
None
1.20A 5i75A-3iauA:
undetectable
5i75A-3iauA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4e UNCHARACTERIZED
PEPTIDASE LMO0363


(Listeria
monocytogenes)
PF03575
(Peptidase_S51)
5 ASP A 136
ILE A 124
ALA A 149
GLY A 117
VAL A  84
SO4  A 207 ( 4.8A)
None
None
None
None
0.96A 5i75A-3l4eA:
undetectable
5i75A-3l4eA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moj ATP-DEPENDENT RNA
HELICASE DBPA


(Bacillus
subtilis)
PF03880
(DbpA)
5 ILE B 416
GLY B 423
PHE B 421
GLY B 469
VAL B 467
None
U  A2554 ( 3.5A)
None
C  A2556 ( 3.1A)
U  A2555 ( 3.9A)
0.98A 5i75A-3mojB:
undetectable
5i75A-3mojB:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbu GLUCOSE-6-PHOSPHATE
ISOMERASE


(Escherichia
coli)
PF00342
(PGI)
5 ILE A 486
ALA A 487
GLY A 296
GLY A 161
VAL A 165
None
1.18A 5i75A-3nbuA:
undetectable
5i75A-3nbuA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbu GLUCOSE-6-PHOSPHATE
ISOMERASE


(Escherichia
coli)
PF00342
(PGI)
5 ILE A 486
ALA A 487
PHE A 345
SER A 481
GLY A 161
None
1.10A 5i75A-3nbuA:
undetectable
5i75A-3nbuA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfb BETA-PEPTIDYL
AMINOPEPTIDASE


(Sphingosinicella
xenopeptidilytica)
PF03576
(Peptidase_S58)
5 ILE A  73
GLY A 209
GLY A 289
GLY A 278
VAL A 277
None
None
OAE  A 376 ( 4.5A)
None
None
0.96A 5i75A-3nfbA:
undetectable
5i75A-3nfbA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7q L-FUCOSE-PROTON
SYMPORTER


(Escherichia
coli)
PF07690
(MFS_1)
5 ILE A 257
ALA A 255
GLY A 377
SER A 250
GLY A 372
None
1.24A 5i75A-3o7qA:
undetectable
5i75A-3o7qA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5p TAXADIENE SYNTHASE

(Taxus
brevifolia)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
5 TYR A 684
TYR A 835
SER A 713
GLY A 715
LEU A 716
None
A3C  A 912 ( 4.4A)
None
A3C  A 911 ( 4.7A)
None
1.20A 5i75A-3p5pA:
2.2
5i75A-3p5pA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqv RCL1 PROTEIN

(Kluyveromyces
lactis)
PF01137
(RTC)
PF05189
(RTC_insert)
5 ALA A 127
GLY A 192
GLY A 135
LEU A 136
GLY A 241
None
PEG  A 410 ( 4.8A)
None
None
None
1.24A 5i75A-3pqvA:
undetectable
5i75A-3pqvA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2k OXIDOREDUCTASE

(Bordetella
pertussis)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
5 ILE A 335
ALA A 334
SER A 328
LEU A 347
GLY A 223
None
1.05A 5i75A-3q2kA:
undetectable
5i75A-3q2kA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvf FOMA PROTEIN

(Streptomyces
wedmorensis)
PF00696
(AA_kinase)
5 ILE A  50
GLY A  12
SER A 148
GLY A 134
LEU A 102
None
FV1  A4001 ( 3.3A)
FV1  A4001 (-2.6A)
FV1  A4001 ( 4.0A)
None
1.03A 5i75A-3qvfA:
undetectable
5i75A-3qvfA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tj0 NUCLEOPROTEIN

(Influenza B
virus)
PF00506
(Flu_NP)
5 ILE A 342
SER A 337
GLY A  87
LEU A  86
GLY A 346
None
1.18A 5i75A-3tj0A:
undetectable
5i75A-3tj0A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5


(Caenorhabditis
elegans)
PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C)
5 ILE A 183
GLY A 232
PHE A 235
GLY A 228
VAL A 192
None
1.13A 5i75A-3ua4A:
undetectable
5i75A-3ua4A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujz METALLOPROTEASE STCE

(Escherichia
coli)
PF10462
(Peptidase_M66)
5 TYR A 713
ALA A 387
PHE A 551
GLY A 714
VAL A 406
None
1.18A 5i75A-3ujzA:
undetectable
5i75A-3ujzA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB


(Pseudomonas
aeruginosa)
PF00873
(ACR_tran)
5 ILE A1001
ALA A1000
GLY A 983
GLY A 397
VAL A 399
None
1.09A 5i75A-3w9iA:
1.8
5i75A-3w9iA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1


(Homo sapiens)
PF00753
(Lactamase_B)
PF12706
(Lactamase_B_2)
5 ASP A 253
ILE A  60
SER A 186
LEU A 123
GLY A  70
ZN  A1363 (-2.5A)
None
None
None
None
0.89A 5i75A-3zwfA:
undetectable
5i75A-3zwfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9a RIBOSOME-INTERACTING
GTPASE 1


(Saccharomyces
cerevisiae)
PF01926
(MMR_HSR1)
PF02824
(TGS)
PF16897
(MMR_HSR1_Xtn)
5 ALA A 140
GLY A 105
SER A  67
GLY A  69
LEU A 146
None
1.06A 5i75A-4a9aA:
3.7
5i75A-4a9aA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aej COLLAGEN
ALPHA-1(III) CHAIN


(Homo sapiens)
PF01410
(COLFI)
5 ILE A 223
ALA A 224
PHE A 117
GLY A 108
VAL A 239
None
1.09A 5i75A-4aejA:
undetectable
5i75A-4aejA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cql ESTRADIOL
17-BETA-DEHYDROGENAS
E 8


(Homo sapiens)
PF13561
(adh_short_C2)
5 ALA A  40
GLY A 105
SER A  21
GLY A  24
VAL A  76
None
NAD  A 301 (-3.5A)
NAD  A 301 (-3.1A)
None
NAD  A 301 (-3.6A)
1.20A 5i75A-4cqlA:
undetectable
5i75A-4cqlA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 14


(Thermus
thermophilus)
PF00361
(Proton_antipo_M)
5 ALA N 372
GLY N 335
LEU N 336
GLY N 244
VAL N 241
None
1.06A 5i75A-4heaN:
2.4
5i75A-4heaN:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 14


(Thermus
thermophilus)
PF00361
(Proton_antipo_M)
5 ALA N 372
TYR N 374
GLY N 335
LEU N 336
GLY N 244
None
1.00A 5i75A-4heaN:
2.4
5i75A-4heaN:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imi SYMPLEKIN

(Drosophila
melanogaster)
PF11935
(DUF3453)
5 ILE A 105
ALA A 151
GLY A 134
LEU A 138
VAL A  90
None
0.99A 5i75A-4imiA:
undetectable
5i75A-4imiA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuh ICE-BINDING PROTEIN

(Leucosporidium)
PF11999
(DUF3494)
5 ALA A  65
GLY A  36
GLY A  63
GLY A  54
VAL A  52
None
0.96A 5i75A-4nuhA:
undetectable
5i75A-4nuhA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9g MBP1

(Caldanaerobius
polysaccharolyticus)
PF13416
(SBP_bac_8)
5 ASP A 305
ILE A 344
ALA A 345
GLY A 270
VAL A 365
BMA  A 502 ( 4.7A)
None
None
None
None
1.09A 5i75A-4r9gA:
undetectable
5i75A-4r9gA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE


(Colias
eurytheme)
PF00342
(PGI)
5 ILE A 494
ALA A 495
GLY A 302
GLY A 167
VAL A 171
None
1.21A 5i75A-4wmjA:
undetectable
5i75A-4wmjA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wut ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)


(Agrobacterium
vitis)
PF13407
(Peripla_BP_4)
5 ILE A 215
ALA A 241
GLY A 187
GLY A 217
VAL A 205
None
1.04A 5i75A-4wutA:
undetectable
5i75A-4wutA:
20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER


(Drosophila
melanogaster)
PF00209
(SNF)
6 ASP A  46
TYR A 123
GLY A 322
SER A 421
GLY A 425
GLY A 480
41U  A 605 ( 3.3A)
None
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
None
0.31A 5i75A-4xnuA:
54.5
5i75A-4xnuA:
53.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4q SORTASE, SRTB FAMILY

(Streptococcus
pneumoniae)
PF04203
(Sortase)
5 ILE A  99
TYR A 101
PHE A 161
LEU A 184
GLY A 156
None
1.15A 5i75A-4y4qA:
undetectable
5i75A-4y4qA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3y BENZOYL-COA
REDUCTASE, PUTATIVE


(Geobacter
metallireducens)
PF01314
(AFOR_C)
PF02730
(AFOR_N)
5 TYR A 546
GLY A  96
GLY A  65
LEU A  66
GLY A 536
None
MTE  A 702 (-3.0A)
None
None
SF4  A 701 ( 4.3A)
1.25A 5i75A-4z3yA:
0.5
5i75A-4z3yA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azd BACTERIORHODOPSIN

(Thermus
thermophilus)
PF01036
(Bac_rhodopsin)
5 ILE A 174
ALA A 173
LEU A 121
GLY A 180
VAL A 183
None
1.25A 5i75A-5azdA:
1.3
5i75A-5azdA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5db4 NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE


(Mycobacteroides
abscessus)
PF01467
(CTP_transf_like)
5 ILE A 108
GLY A  21
SER A 136
GLY A 110
LEU A 114
None
ATP  A 301 (-3.7A)
None
ATP  A 301 (-3.0A)
None
0.75A 5i75A-5db4A:
undetectable
5i75A-5db4A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex8 CYTOCHROME P450

(Streptomyces
toyocaensis)
PF00067
(p450)
5 ILE A 217
ALA A 216
GLY A 210
GLY A  83
VAL A 225
None
1.11A 5i75A-5ex8A:
2.0
5i75A-5ex8A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA PRIMASE LARGE
SUBUNIT


(Homo sapiens)
PF04104
(DNA_primase_lrg)
5 ASP B 361
ILE B 349
GLY B 310
LEU B 313
GLY B 344
None
1.18A 5i75A-5exrB:
undetectable
5i75A-5exrB:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9p GALECTIN-3

(Homo sapiens)
PF00337
(Gal-bind_lectin)
5 ASP A 215
ILE A 200
PHE A 192
LEU A 219
GLY A 136
None
1.10A 5i75A-5h9pA:
undetectable
5i75A-5h9pA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i47 RIMK DOMAIN PROTEIN
ATP-GRASP


(Sphaerobacter
thermophilus)
PF08443
(RimK)
5 ILE A 268
ALA A 265
GLY A 274
GLY A 230
VAL A  77
None
1.10A 5i75A-5i47A:
undetectable
5i75A-5i47A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i51 TRANSKETOLASE

(Scheffersomyces
stipitis)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 ILE A 512
ALA A 511
SER A 505
LEU A 521
VAL A 370
None
1.23A 5i75A-5i51A:
undetectable
5i75A-5i51A:
22.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER


(Homo sapiens)
PF00209
(SNF)
12 TYR A  95
ASP A  98
ILE A 172
ALA A 173
TYR A 175
GLY A 338
PHE A 341
SER A 438
GLY A 442
LEU A 443
GLY A 498
VAL A 501
None
0.40A 5i75A-5i6zA:
61.1
5i75A-5i6zA:
99.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE


(Mycolicibacterium
thermoresistibile)
PF00982
(Glyco_transf_20)
5 GLY A 203
PHE A 207
LEU A 214
GLY A 231
VAL A 242
None
1.21A 5i75A-5jijA:
undetectable
5i75A-5jijA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE


(Caenorhabditis
elegans)
PF01676
(Metalloenzyme)
PF06415
(iPGM_N)
5 ILE A 291
ALA A 213
GLY A 317
GLY A 139
GLY A 296
None
1.08A 5i75A-5kgnA:
undetectable
5i75A-5kgnA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE


(Caenorhabditis
elegans)
PF01676
(Metalloenzyme)
PF06415
(iPGM_N)
5 ILE A 291
ALA A 213
GLY A 317
PHE A 280
GLY A 139
None
1.20A 5i75A-5kgnA:
undetectable
5i75A-5kgnA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA


(Methylobacillus
flagellatus)
PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
5 ASP A  36
SER A  33
GLY A  58
LEU A  57
GLY A  80
None
1.21A 5i75A-5ks8A:
undetectable
5i75A-5ks8A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN


(Francisella
tularensis)
PF00290
(Trp_syntA)
5 GLY A 173
GLY A  99
LEU A  51
GLY A 231
VAL A 210
None
0.85A 5i75A-5kzmA:
undetectable
5i75A-5kzmA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN


(Francisella
tularensis)
PF00290
(Trp_syntA)
5 ILE A  21
GLY A 173
GLY A  99
LEU A  51
VAL A 210
None
0.79A 5i75A-5kzmA:
undetectable
5i75A-5kzmA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME


(Lysobacter sp.
XL1)
no annotation 5 ALA A  36
GLY A 150
LEU A 163
GLY A  56
VAL A  48
None
None
None
FMT  A 303 ( 4.4A)
None
1.25A 5i75A-5mrtA:
undetectable
5i75A-5mrtA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfb GALECTIN-3

(Homo sapiens)
PF00337
(Gal-bind_lectin)
5 ASP A 215
ILE A 200
PHE A 192
LEU A 219
GLY A 136
None
1.05A 5i75A-5nfbA:
undetectable
5i75A-5nfbA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ntf AMINOPEPTIDASE

(Trypanosoma
cruzi)
PF00883
(Peptidase_M17)
5 ALA A 399
GLY A 295
GLY A 373
LEU A 377
GLY A 307
None
None
SO4  A 601 (-3.0A)
None
None
0.89A 5i75A-5ntfA:
undetectable
5i75A-5ntfA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nth PUTATIVE
AMINOPEPTIDASE


(Leishmania
major)
PF00883
(Peptidase_M17)
5 ILE A 394
TYR A 369
GLY A 493
PHE A 496
GLY A 397
None
1.24A 5i75A-5nthA:
undetectable
5i75A-5nthA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1o GLUTATHIONE
REDUCTASE


(Vibrio
parahaemolyticus)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ILE A  99
GLY A  50
SER A  18
GLY A  43
LEU A  42
None
FAD  A 501 (-3.4A)
FAD  A 501 (-3.4A)
None
None
1.06A 5i75A-5u1oA:
2.8
5i75A-5u1oA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5us8 ARGININOSUCCINATE
SYNTHASE


(Bordetella
pertussis)
PF00764
(Arginosuc_synth)
5 TYR A 143
GLY A 334
GLY A 111
LEU A 114
GLY A 134
None
1.13A 5i75A-5us8A:
undetectable
5i75A-5us8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usd PEPTIDASE S66

(Bacillus
anthracis)
PF02016
(Peptidase_S66)
5 ILE A 113
PHE A 107
SER A  16
LEU A  91
GLY A 131
None
1.18A 5i75A-5usdA:
undetectable
5i75A-5usdA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v36 GLUTATHIONE
REDUCTASE


(Streptococcus
mutans)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ILE A 178
ALA A 179
GLY A 141
GLY A 262
GLY A  46
FAD  A 501 ( 4.1A)
None
None
CL  A 505 (-3.4A)
FAD  A 501 ( 3.7A)
1.02A 5i75A-5v36A:
0.5
5i75A-5v36A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v3s TWO-COMPONENT
INSECTICIDAL PROTEIN
16 KDA UNIT


(Alcaligenes
faecalis)
PF06355
(Aegerolysin)
5 TYR A 100
ASP A 111
GLY A  85
LEU A  38
GLY A 107
None
1.13A 5i75A-5v3sA:
undetectable
5i75A-5v3sA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aph ADENOSYLHOMOCYSTEINA
SE


(Elizabethkingia
anophelis)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 ILE A 208
ALA A 207
GLY A 241
PHE A 237
VAL A 221
None
1.19A 5i75A-6aphA:
undetectable
5i75A-6aphA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzc GLUCOSE-6-PHOSPHATE
ISOMERASE


(Elizabethkingia
anophelis)
no annotation 5 ILE A 485
ALA A 486
GLY A 295
GLY A 161
VAL A 165
None
1.20A 5i75A-6bzcA:
undetectable
5i75A-6bzcA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER


(Enterococcus
casseliflavus)
no annotation 5 GLY A 330
SER A 296
LEU A 301
GLY A 230
VAL A 352
None
1.05A 5i75A-6d0nA:
undetectable
5i75A-6d0nA:
9.62