SIMILAR PATTERNS OF AMINO ACIDS FOR 5I73_A_68PA705_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnz GSI-B4 ISOLECTIN

(Griffonia
simplicifolia) 		PF00139
(Lectin_legB) 		5 ALA A  52
GLN A  23
PHE A  22
LEU A  33
PHE A   9
 None
 1.41A 5i73A-1gnzA:
undetectable		 5i73A-1gnzA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyu ADAPTER-RELATED
PROTEIN COMPLEX 1
GAMMA 1 SUBUNIT

(Mus musculus) 		PF02883
(Alpha_adaptinC2) 		5 ARG A 793
GLN A 791
PHE A 816
GLU A 812
ILE A 707
 None
 1.47A 5i73A-1gyuA:
undetectable		 5i73A-1gyuA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o12 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		5 ARG A 194
ALA A 174
PRO A 199
LEU A 202
ILE A 212
 None
 1.34A 5i73A-1o12A:
0.0		 5i73A-1o12A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3d CRYPTOCHROME 1
APOPROTEIN

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 ALA A 333
GLN A 336
GLU A 328
LEU A 373
ILE A 474
 None
 1.46A 5i73A-1u3dA:
0.1		 5i73A-1u3dA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		5 ALA A  79
PRO A 237
LEU A 236
ILE A 205
PHE A 235
 None
 1.45A 5i73A-2ehqA:
3.9		 5i73A-2ehqA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eid GALACTOSE OXIDASE

(Fusarium
graminearum) 		PF00754
(F5_F8_type_C)
PF01344
(Kelch_1)
PF09118
(DUF1929) 		5 ALA A 348
GLN A 347
PHE A 346
LEU A 419
ILE A 396
 None
 1.49A 5i73A-2eidA:
undetectable		 5i73A-2eidA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ej7 HCG3 GENE

(Homo sapiens) 		PF00226
(DnaJ) 		5 ALA A  21
GLN A  20
GLU A  13
LEU A  63
ILE A  26
 None
 1.30A 5i73A-2ej7A:
2.0		 5i73A-2ej7A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0t CONSERVED
HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		PF07755
(DUF1611)
PF17396
(DUF1611_N) 		5 ALA A 189
PHE A 237
GLU A 180
LEU A 332
ILE A 187
 None
 1.31A 5i73A-2g0tA:
0.0		 5i73A-2g0tA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i79 ACETYLTRANSFERASE,
GNAT FAMILY

(Streptococcus
pneumoniae) 		PF00583
(Acetyltransf_1) 		5 ALA A 115
GLN A 116
GLU A 110
LEU A  90
ILE A  76
 None
 1.44A 5i73A-2i79A:
undetectable		 5i73A-2i79A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l08 REGULATOR OF
NONSENSE TRANSCRIPTS
3A

(Homo sapiens) 		PF03467
(Smg4_UPF3) 		5 ALA A  56
PHE A  42
GLU A  27
LEU A  17
ILE A  14
 None
 1.44A 5i73A-2l08A:
undetectable		 5i73A-2l08A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lcj PAB POLC INTEIN

(Pyrococcus
abyssi) 		PF14890
(Intein_splicing) 		5 GLN A  17
GLU A  26
LEU A 167
ILE A   8
PHE A 165
 None
 1.30A 5i73A-2lcjA:
undetectable		 5i73A-2lcjA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00583
(Acetyltransf_1)
PF00696
(AA_kinase) 		5 GLN A  20
PHE A 272
GLU A 270
LEU A  50
ILE A  55
 None
 1.34A 5i73A-2r98A:
0.0		 5i73A-2r98A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zf5 GLYCEROL KINASE

(Thermococcus
kodakarensis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ALA O  62
GLU O 428
LEU O   6
ILE O  19
PHE O  20
 None
 1.31A 5i73A-2zf5O:
0.0		 5i73A-2zf5O:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efz 14-3-3 PROTEIN

(Cryptosporidium
parvum) 		PF00244
(14-3-3) 		5 ARG A  72
ALA A 266
PHE A 267
PRO A 193
LEU A 244
 None
SEP  A 265 ( 3.7A)
None
None
None
 1.44A 5i73A-3efzA:
5.4		 5i73A-3efzA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk4 RUBISCO-LIKE PROTEIN

(Bacillus cereus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ALA A 232
GLN A 231
PRO A 186
LEU A 187
ILE A 191
 None
 1.25A 5i73A-3fk4A:
undetectable		 5i73A-3fk4A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivr PUTATIVE
LONG-CHAIN-FATTY-ACI
D COA LIGASE

(Rhodopseudomonas
palustris) 		PF00501
(AMP-binding) 		5 ALA A 242
GLN A 240
PRO A 269
LEU A 272
ILE A 263
 None
 1.45A 5i73A-3ivrA:
0.0		 5i73A-3ivrA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5o UNCHARACTERIZED
PROTEIN FROM DUF364
FAMILY

(Desulfitobacterium
hafniense) 		PF04016
(DUF364)
PF13938
(DUF4213) 		5 GLN A 215
GLU A 188
PRO A 184
LEU A 183
ILE A 173
 None
 1.40A 5i73A-3l5oA:
0.0		 5i73A-3l5oA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		5 ALA A 263
GLN A 212
PRO A 254
ILE A 259
PHE A 255
 None
 1.39A 5i73A-3lk6A:
2.0		 5i73A-3lk6A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdq EXOPOLYPHOSPHATASE

(Cytophaga
hutchinsonii) 		PF02541
(Ppx-GppA) 		5 GLN A 156
PHE A 144
GLU A 195
LEU A 278
ILE A 160
 None
 1.26A 5i73A-3mdqA:
undetectable		 5i73A-3mdqA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 PHE A 408
GLU A 256
LEU A 406
ILE A 171
PHE A 175
 None
 1.47A 5i73A-3o04A:
undetectable		 5i73A-3o04A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9i MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN

(Roseiflexus sp.
RS-1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A  35
GLU A 310
PRO A 336
LEU A 339
ILE A  19
 None
 1.25A 5i73A-3u9iA:
undetectable		 5i73A-3u9iA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE

(Caldanaerobius
polysaccharolyticus) 		PF00150
(Cellulase) 		5 GLN A 108
PHE A 111
GLU A 116
LEU A 134
ILE A 155
 None
 1.49A 5i73A-3w0kA:
undetectable		 5i73A-3w0kA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs6 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Burkholderia
pseudomallei) 		PF00496
(SBP_bac_5) 		5 GLN A 344
PHE A 289
PRO A 302
LEU A 300
ILE A 284
 None
 1.28A 5i73A-3zs6A:
undetectable		 5i73A-3zs6A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX BETA-CHAIN
FADA

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ALA C 103
GLN C 104
GLU C   4
ILE C 269
PHE C   6
 None
 1.12A 5i73A-4b3iC:
undetectable		 5i73A-4b3iC:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eme M18 ASPARTYL
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF02127
(Peptidase_M18) 		5 ARG A  19
ALA A  26
PHE A  16
GLU A  32
ILE A  88
 None
 1.43A 5i73A-4emeA:
undetectable		 5i73A-4emeA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 305
GLN A 303
PRO A 345
LEU A 342
ILE A 363
 None
 1.43A 5i73A-4hpnA:
undetectable		 5i73A-4hpnA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Neisseria
meningitidis) 		PF13561
(adh_short_C2) 		5 ALA A  33
GLN A   5
GLU A  30
LEU A  35
ILE A   9
 None
 1.30A 5i73A-4m87A:
undetectable		 5i73A-4m87A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE

(Streptococcus
mutans) 		PF00155
(Aminotran_1_2) 		5 GLN A 228
GLU A 193
PRO A 153
LEU A 156
ILE A 160
 None
 1.34A 5i73A-4my5A:
1.5		 5i73A-4my5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Methanocaldococcus
jannaschii) 		PF02350
(Epimerase_2) 		5 ARG A  10
PHE A 274
LEU A 203
ILE A 237
PHE A 238
 UDP  A 401 (-3.5A)
UDP  A 401 (-3.4A)
None
None
None
 1.34A 5i73A-4nesA:
undetectable		 5i73A-4nesA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opu CONSERVED ARCHAEAL
PROTEIN

(Sulfolobus
acidocaldarius) 		PF01266
(DAO) 		5 ALA A 345
GLN A 344
LEU A 444
ILE A 419
PHE A 447
 None
 1.49A 5i73A-4opuA:
undetectable		 5i73A-4opuA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlp ALANINE AND PROLINE
RICH PROTEIN,
TUBERCULOSIS
NECROTIZING TOXIN
(TNT)

(Mycobacterium
tuberculosis) 		PF14021
(TNT) 		5 ALA B 686
GLN B 687
PRO B 695
LEU B 787
ILE B 681
 None
 1.46A 5i73A-4qlpB:
undetectable		 5i73A-4qlpB:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlv ANKYRIN-1, ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		5 ALA A2769
GLN A2770
PRO A2787
LEU A2813
ILE A2777
 None
 1.24A 5i73A-4rlvA:
undetectable		 5i73A-4rlvA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whn APXC

(Actinobacillus
pleuropneumoniae) 		PF02794
(HlyC) 		5 ALA A 144
PHE A 148
LEU A 116
ILE A 139
PHE A 134
 None
 1.42A 5i73A-4whnA:
undetectable		 5i73A-4whnA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA

(Escherichia
virus T4;
Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00959
(Phage_lysozyme) 		5 ARG A 313
ALA A 341
GLU A 261
ILE A 343
PHE A 259
 None
None
None
ATP  A1201 (-3.6A)
ATP  A1201 (-3.2A)
 1.50A 5i73A-4wtvA:
1.9		 5i73A-4wtvA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 GLN A 287
PHE A 291
GLU A 463
LEU A 457
ILE A 452
 None
 1.46A 5i73A-4yhjA:
1.9		 5i73A-4yhjA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zju ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Acinetobacter
baumannii) 		PF13561
(adh_short_C2) 		5 ARG A  32
ALA A  27
GLN A  28
ILE A  13
PHE A  11
 None
 1.28A 5i73A-4zjuA:
undetectable		 5i73A-4zjuA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa4 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F

(Pseudomonas
aeruginosa) 		PF00497
(SBP_bac_3)
PF01464
(SLT) 		5 ALA B 252
GLN B 251
PHE B 248
GLU B  76
LEU B  70
 None
 1.39A 5i73A-5aa4B:
undetectable		 5i73A-5aa4B:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5enu ALKYL HYDROPEROXIDE
REDUCTASE/ THIOL
SPECIFIC
ANTIOXIDANT/ MAL
ALLERGEN

(Burkholderia
ambifaria) 		PF00578
(AhpC-TSA) 		5 ARG A 135
PHE A 101
GLU A   4
PRO A  10
ILE A 124
 None
 1.24A 5i73A-5enuA:
undetectable		 5i73A-5enuA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjp OXYSTEROLS RECEPTOR
LXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA B 286
GLN B 288
GLU B 315
LEU B 304
ILE B 378
 None
 1.42A 5i73A-5hjpB:
undetectable		 5i73A-5hjpB:
19.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER

(Homo sapiens) 		PF00209
(SNF) 		7 ARG A 104
ALA A 331
GLN A 332
PHE A 335
PRO A 499
LEU A 502
ILE A 552
 None
 0.73A 5i73A-5i6zA:
61.3		 5i73A-5i6zA:
99.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5itg SORBITOL
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 ALA A 221
PHE A 183
LEU A 172
ILE A 217
PHE A 202
 None
 1.23A 5i73A-5itgA:
undetectable		 5i73A-5itgA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ivw GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 3

(Homo sapiens) 		PF03850
(Tfb4) 		5 ALA 3 206
GLN 3 205
PHE 3 177
LEU 3 137
ILE 3 191
 None
 1.41A 5i73A-5ivw3:
undetectable		 5i73A-5ivw3:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ore OCTOPINE-BINDING
PERIPLASMIC PROTEIN

(Agrobacterium
tumefaciens) 		no annotation 5 GLN A 276
PRO A 223
LEU A 224
ILE A 110
PHE A 225
 None
 1.29A 5i73A-5oreA:
undetectable		 5i73A-5oreA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B
TUNGSTEN-CONTAINING
FORMYLMETHANOFURAN
DEHYDROGENASE 2
SUBUNIT C

(Methanothermobacter
sp. CaT2;
Methanothermobacter
wolfeii) 		PF00384
(Molybdopterin)
PF01493
(GXGXG) 		5 ARG C 141
ALA B 125
GLN B 127
GLU C 161
ILE B 266
 None
 1.34A 5i73A-5t5iC:
undetectable		 5i73A-5t5iC:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wkh D30 TCR BETA CHAIN

(Homo sapiens) 		no annotation 5 ALA E  78
PRO E  72
LEU E  71
ILE E  54
PHE E  76
 None
 1.43A 5i73A-5wkhE:
undetectable		 5i73A-5wkhE:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrj PROTEIN-TYROSINE
SULFOTRANSFERASE 1

(Homo sapiens) 		PF13469
(Sulfotransfer_3) 		5 GLN A 258
PHE A 256
LEU A 180
ILE A  72
PHE A 179
 None
 1.34A 5i73A-5wrjA:
undetectable		 5i73A-5wrjA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4f ANKYRIN-2

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		5 ALA A 768
GLN A 769
PRO A 786
LEU A 812
ILE A 776
 None
 1.37A 5i73A-5y4fA:
undetectable		 5i73A-5y4fA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y81 ACTIN-RELATED
PROTEIN 4

(Saccharomyces
cerevisiae) 		no annotation 5 ALA F 405
PHE F 437
PRO F 433
LEU F 432
ILE F 393
 None
 1.16A 5i73A-5y81F:
undetectable		 5i73A-5y81F:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA

(Pyrococcus
furiosus) 		no annotation 5 ARG L 199
ALA M 296
GLN M 295
PRO M 208
LEU M 136
 None
 1.34A 5i73A-6cfwL:
1.9		 5i73A-6cfwL:
9.51