SIMILAR PATTERNS OF AMINO ACIDS FOR 5I73_A_68PA701

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)

(Thermotoga
maritima) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 GLY A 185
GLY A 178
LEU A 204
GLY A  91
VAL A 190
 None
 0.84A 5i73A-1c3cA:
undetectable		 5i73A-1c3cA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c6o CYTOCHROME C6

(Tetradesmus
obliquus) 		PF13442
(Cytochrome_CBB3) 		5 ILE A  73
ALA A  74
GLY A  57
LEU A  47
GLY A  66
 None
 0.94A 5i73A-1c6oA:
undetectable		 5i73A-1c6oA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ccw PROTEIN (GLUTAMATE
MUTASE)

(Clostridium
cochlearium) 		PF06368
(Met_asp_mut_E) 		5 ASP B 198
ALA B 148
GLY B 174
LEU B 158
GLY B 217
 None
 0.99A 5i73A-1ccwB:
0.0		 5i73A-1ccwB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)

(Escherichia
coli) 		PF00709
(Adenylsucc_synt) 		5 ASP A 411
ILE A 402
GLY A 264
LEU A 332
VAL A 315
 None
 0.83A 5i73A-1cg4A:
0.0		 5i73A-1cg4A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		5 ILE A 392
ALA A 368
PHE A 277
GLY A 305
VAL A 255
 None
 0.93A 5i73A-1e5dA:
undetectable		 5i73A-1e5dA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evj GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ILE A  47
ALA A  43
TYR A  42
GLY A  53
PHE A  51
 None
None
NAD  A 500 (-3.5A)
None
None
 0.96A 5i73A-1evjA:
0.0		 5i73A-1evjA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ILE B 286
GLY B 228
GLY B 289
LEU B 288
GLY B 251
 None
 0.99A 5i73A-1ffvB:
0.0		 5i73A-1ffvB:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6d PRECURSOR FORM OF
GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ILE A  99
ALA A  95
TYR A  94
GLY A 105
PHE A 103
 None
None
NDP  A 500 (-3.4A)
None
None
 0.94A 5i73A-1h6dA:
0.0		 5i73A-1h6dA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig8 HEXOKINASE PII

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		6 ILE A 453
ALA A 432
GLY A 418
PHE A 232
GLY A 229
VAL A 230
 None
None
SO4  A 501 (-3.1A)
None
None
None
 1.41A 5i73A-1ig8A:
0.4		 5i73A-1ig8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jji CARBOXYLESTERASE

(Archaeoglobus
fulgidus) 		PF07859
(Abhydrolase_3) 		5 TYR A  16
ILE A  36
ALA A  35
TYR A  32
GLY A  88
 None
None
None
None
EPE  A 455 (-3.7A)
 0.92A 5i73A-1jjiA:
undetectable		 5i73A-1jjiA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jny ELONGATION FACTOR
1-ALPHA

(Sulfolobus
solfataricus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 ASP A 311
GLY A 271
GLY A 314
LEU A 233
GLY A 301
 None
 0.89A 5i73A-1jnyA:
undetectable		 5i73A-1jnyA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp0 CREATINE
AMIDINOHYDROLASE

(Actinobacillus) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 ILE A 184
ALA A 181
GLY A 242
GLY A 187
VAL A 239
 None
 0.90A 5i73A-1kp0A:
undetectable		 5i73A-1kp0A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Methanothermobacter
thermautotrophicus) 		PF00483
(NTP_transferase) 		5 ALA A  87
PHE A  96
GLY A  98
GLY A   3
VAL A 102
 None
 0.97A 5i73A-1lvwA:
undetectable		 5i73A-1lvwA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1naa CELLOBIOSE
DEHYDROGENASE

(Phanerochaete
chrysosporium) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ILE A 229
ALA A 232
GLY A 305
GLY A 223
GLY A 405
 None
None
6FA  A 801 (-3.5A)
6FA  A 801 (-3.0A)
None
 0.95A 5i73A-1naaA:
undetectable		 5i73A-1naaA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvd PYRUVATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ALA A 425
GLY A  84
GLY A 420
GLY A  94
VAL A  95
 None
 0.94A 5i73A-1pvdA:
undetectable		 5i73A-1pvdA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryy ALPHA-AMINO ACID
ESTER HYDROLASE

(Acetobacter
pasteurianus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		5 ASP A 354
ILE A 346
ALA A 345
GLY A 526
VAL A 527
 None
 0.99A 5i73A-1ryyA:
undetectable		 5i73A-1ryyA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT

(Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ALA A 281
GLY A 320
GLY A 284
GLY A  82
VAL A  83
 None
 0.92A 5i73A-1sb3A:
undetectable		 5i73A-1sb3A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		5 GLY A 350
GLY A 249
LEU A 321
GLY A 210
VAL A 208
 None
None
None
EDO  A1232 ( 4.8A)
None
 0.95A 5i73A-1szsA:
undetectable		 5i73A-1szsA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to6 GLYCERATE KINASE

(Neisseria
meningitidis) 		PF02595
(Gly_kinase) 		5 ILE A 112
GLY A 249
GLY A 142
GLY A 130
VAL A 131
 None
 0.98A 5i73A-1to6A:
undetectable		 5i73A-1to6A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uan HYPOTHETICAL PROTEIN
TT1542

(Thermus
thermophilus) 		PF02585
(PIG-L) 		5 ALA A 169
GLY A 147
GLY A  14
GLY A 190
VAL A 186
 None
 0.95A 5i73A-1uanA:
undetectable		 5i73A-1uanA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxj TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Thermus
thermophilus) 		PF00290
(Trp_syntA) 		5 ALA A 223
PHE A  95
GLY A 208
GLY A 169
VAL A 148
 None
None
IPL  A1001 (-3.8A)
None
None
 0.89A 5i73A-1wxjA:
undetectable		 5i73A-1wxjA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		6 ASP A 590
ILE A 571
PHE A 551
GLY A 555
LEU A 558
GLY A 582
 None
 1.39A 5i73A-1yr2A:
undetectable		 5i73A-1yr2A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0j PTS SYSTEM, NITROGEN
REGULATORY IIA
PROTEIN

(Neisseria
meningitidis) 		PF00359
(PTS_EIIA_2) 		5 GLY A  68
GLY A  30
LEU A  31
GLY A  72
VAL A  73
 None
 0.91A 5i73A-2a0jA:
undetectable		 5i73A-2a0jA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeu HYPOTHETICAL PROTEIN
MJ0158

(Methanocaldococcus
jannaschii) 		PF03841
(SelA) 		5 ILE A 228
ALA A  95
GLY A  81
GLY A 232
GLY A 220
 None
 0.95A 5i73A-2aeuA:
undetectable		 5i73A-2aeuA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0a TRANSCRIPTIONAL
REGULATOR

(Thermus
thermophilus) 		PF13377
(Peripla_BP_3) 		6 ILE A 183
ALA A 184
PHE A 238
LEU A 221
GLY A 258
VAL A 259
 None
 1.39A 5i73A-2h0aA:
undetectable		 5i73A-2h0aA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hhz PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-RELATED

(Streptococcus
suis) 		PF01243
(Putative_PNPOx) 		5 ILE A  42
ALA A  37
PHE A  18
GLY A  81
VAL A  62
 None
 0.98A 5i73A-2hhzA:
undetectable		 5i73A-2hhzA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jah CLAVULANIC ACID
DEHYDROGENASE

(Streptomyces
clavuligerus) 		PF00106
(adh_short) 		5 ALA A  10
GLY A  55
GLY A  31
LEU A   5
GLY A  48
 None
 0.97A 5i73A-2jahA:
undetectable		 5i73A-2jahA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mss PROTEIN (MUSASHI1)

(Mus musculus) 		PF00076
(RRM_1) 		5 ILE A 111
ALA A 184
GLY A 153
GLY A 133
VAL A 135
 None
 0.89A 5i73A-2mssA:
undetectable		 5i73A-2mssA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nun AVIRULENCE B PROTEIN

(Pseudomonas
savastanoi) 		PF05394
(AvrB_AvrC) 		5 ILE A 238
TYR A 234
GLY A  31
LEU A 242
GLY A  84
 None
 0.98A 5i73A-2nunA:
undetectable		 5i73A-2nunA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ILE A 229
ALA A 236
GLY A 448
GLY A 411
GLY A  87
 GLC  A1001 (-4.2A)
None
BG6  A1002 (-3.6A)
None
UNX  A   6 ( 3.4A)
 0.98A 5i73A-2nztA:
undetectable		 5i73A-2nztA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o96 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 7

(Homo sapiens) 		PF01398
(JAB) 		5 ILE A 108
ALA A 107
GLY A  98
GLY A  37
VAL A  36
 None
 0.97A 5i73A-2o96A:
undetectable		 5i73A-2o96A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50

(Geobacillus
stearothermophilus) 		PF00135
(COesterase) 		5 ASP A 380
ILE A 304
PHE A 488
LEU A 204
VAL A 306
 ASP  A 380 ( 0.6A)
ILE  A 304 ( 0.7A)
PHE  A 488 ( 1.3A)
LEU  A 204 ( 0.6A)
VAL  A 306 ( 0.6A)
 0.95A 5i73A-2ogsA:
undetectable		 5i73A-2ogsA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qna IMPORTIN SUBUNIT
BETA-1

(Homo sapiens) 		PF13513
(HEAT_EZ) 		5 ALA A 631
GLY A 620
PHE A 615
LEU A 558
GLY A 657
 None
 0.94A 5i73A-2qnaA:
undetectable		 5i73A-2qnaA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ALA A 425
GLY A  84
GLY A 420
GLY A  94
VAL A  95
 None
 0.94A 5i73A-2vk4A:
undetectable		 5i73A-2vk4A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ALA A 209
GLY A  61
PHE A 239
LEU A 205
GLY A 236
 None
None
GOL  A1421 (-4.2A)
None
None
 0.97A 5i73A-2wgeA:
undetectable		 5i73A-2wgeA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Mycobacterium
tuberculosis) 		PF00342
(PGI) 		5 ILE A 486
ALA A 487
GLY A 280
PHE A 295
VAL A 167
 None
 0.96A 5i73A-2wu8A:
2.2		 5i73A-2wu8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 500
PHE A 132
GLY A 457
GLY A 522
VAL A  83
 BR  A1723 (-3.6A)
None
None
None
None
 0.98A 5i73A-2x40A:
undetectable		 5i73A-2x40A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae) 		PF00202
(Aminotran_3) 		5 ALA A 116
PHE A 147
GLY A 143
GLY A 200
VAL A 130
 None
 0.96A 5i73A-2zukA:
undetectable		 5i73A-2zukA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		5 TYR A 105
GLY A 389
GLY A 383
GLY A  72
VAL A  61
 None
None
FAD  A 618 (-2.9A)
None
None
 0.97A 5i73A-2zxhA:
undetectable		 5i73A-2zxhA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		5 ILE A 587
ALA A 588
GLY A 648
LEU A 415
GLY A 624
 None
 0.94A 5i73A-3ai7A:
undetectable		 5i73A-3ai7A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermotoga
maritima) 		PF01425
(Amidase) 		5 ILE A 452
ALA A 455
PHE A 247
LEU A 276
GLY A 441
 None
 0.97A 5i73A-3al0A:
undetectable		 5i73A-3al0A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8a HEXOKINASE-1

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		6 ILE X 452
ALA X 432
GLY X 418
PHE X 232
GLY X 229
VAL X 230
 None
None
SO4  X 502 ( 3.8A)
None
None
None
 1.43A 5i73A-3b8aX:
undetectable		 5i73A-3b8aX:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg2 DGTP
TRIPHOSPHOHYDROLASE

(Leeuwenhoekiella
blandensis) 		PF01966
(HD) 		5 ASP A  36
ALA A 115
GLY A  30
LEU A 168
GLY A 106
 None
 0.99A 5i73A-3bg2A:
undetectable		 5i73A-3bg2A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpg UNCHARACTERIZED
PROTEIN

(Bifidobacterium
adolescentis) 		PF01168
(Ala_racemase_N) 		5 ASP A 237
ALA A 187
GLY A 200
LEU A 201
GLY A 195
 None
 0.99A 5i73A-3cpgA:
undetectable		 5i73A-3cpgA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		5 ILE A 818
ALA A 851
GLY A 732
GLY A 820
VAL A 791
 None
 0.94A 5i73A-3cttA:
undetectable		 5i73A-3cttA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00389
(2-Hacid_dh)
PF01842
(ACT)
PF02826
(2-Hacid_dh_C) 		5 ALA A 417
GLY A 429
GLY A 335
LEU A 373
GLY A 445
 None
 0.99A 5i73A-3ddnA:
undetectable		 5i73A-3ddnA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0f PUTATIVE
METAL-DEPENDENT
PHOSPHOESTERASE

(Bifidobacterium
adolescentis) 		PF02811
(PHP) 		5 ASP A  15
ALA A  58
GLY A  72
LEU A  71
GLY A  25
 None
 0.96A 5i73A-3e0fA:
undetectable		 5i73A-3e0fA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldf PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.776

(Streptococcus
mutans) 		PF10672
(Methyltrans_SAM) 		5 ILE A 327
ALA A 329
PHE A 349
GLY A 325
VAL A 385
 None
 0.96A 5i73A-3ldfA:
undetectable		 5i73A-3ldfA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moj ATP-DEPENDENT RNA
HELICASE DBPA

(Bacillus
subtilis) 		PF03880
(DbpA) 		5 ILE B 416
GLY B 423
PHE B 421
GLY B 469
VAL B 467
 None
U  A2554 ( 3.5A)
None
C  A2556 ( 3.1A)
U  A2555 ( 3.9A)
 0.99A 5i73A-3mojB:
undetectable		 5i73A-3mojB:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfb BETA-PEPTIDYL
AMINOPEPTIDASE

(Sphingosinicella
xenopeptidilytica) 		PF03576
(Peptidase_S58) 		5 ILE A  73
GLY A 209
GLY A 289
GLY A 278
VAL A 277
 None
None
OAE  A 376 ( 4.5A)
None
None
 0.95A 5i73A-3nfbA:
undetectable		 5i73A-3nfbA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qoy 50S RIBOSOMAL
PROTEIN L1

(Aquifex
aeolicus) 		PF00687
(Ribosomal_L1) 		5 ALA A 118
GLY A 180
GLY A 139
GLY A 163
VAL A 165
 None
 0.90A 5i73A-3qoyA:
undetectable		 5i73A-3qoyA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slr UNCHARACTERIZED
PROTEIN BF1531

(Bacteroides
fragilis) 		no annotation 5 ILE A 226
ALA A 276
GLY A 350
LEU A 324
VAL A 344
 None
 0.96A 5i73A-3slrA:
undetectable		 5i73A-3slrA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3w ENOYL-COA HYDRATASE

(Mycolicibacterium
thermoresistibile) 		PF00378
(ECH_1) 		5 ILE A 139
ALA A 119
PHE A 147
GLY A 192
VAL A 188
 None
None
None
TRS  A 302 ( 4.3A)
None
 0.96A 5i73A-3t3wA:
undetectable		 5i73A-3t3wA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thc BETA-GALACTOSIDASE

(Homo sapiens) 		PF01301
(Glyco_hydro_35)
PF13364
(BetaGal_dom4_5) 		5 ALA A 443
TYR A 444
GLY A 481
GLY A 494
LEU A 495
 None
 0.99A 5i73A-3thcA:
undetectable		 5i73A-3thcA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H

(Escherichia
coli) 		PF01795
(Methyltransf_5) 		5 ILE A  98
GLY A  93
LEU A  19
GLY A  83
VAL A  86
 None
 0.94A 5i73A-3tkaA:
undetectable		 5i73A-3tkaA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tnl SHIKIMATE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF08501
(Shikimate_dh_N) 		5 ILE A  80
PHE A  62
GLY A  69
GLY A 109
LEU A  87
 None
 0.86A 5i73A-3tnlA:
undetectable		 5i73A-3tnlA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
V-TYPE SODIUM ATPASE
SUBUNIT B

(Enterococcus
hirae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		6 TYR D  26
ILE D 222
ALA D 223
TYR D 253
GLY A  11
LEU D  77
 None
 1.33A 5i73A-3vr5D:
undetectable		 5i73A-3vr5D:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuq TRANSCRIPTIONAL
REGULATOR (TETR/ACRR
FAMILY)

(Thermus
thermophilus) 		PF00440
(TetR_N) 		5 ILE A 159
ALA A 160
PHE A  86
GLY A 140
LEU A 130
 None
 0.90A 5i73A-3vuqA:
2.4		 5i73A-3vuqA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxw ADIPONECTIN RECEPTOR
PROTEIN 2

(Homo sapiens) 		PF03006
(HlyIII) 		6 ALA A 318
PHE A 187
GLY A 229
PHE A 231
GLY A 286
LEU A 287
 None
 1.29A 5i73A-3wxwA:
2.0		 5i73A-3wxwA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0u UNCHARACTERIZED
PROTEIN

(Vibrio
parahaemolyticus) 		PF03945
(Endotoxin_N) 		5 ASP A 230
ALA A 425
GLY A 275
PHE A 422
VAL A 365
 None
 1.00A 5i73A-3x0uA:
2.3		 5i73A-3x0uA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0n POLYKETIDE SYNTHASE
III

(Ectocarpus
siliculosus) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 ASP A 206
ILE A 267
ALA A 266
GLY A 200
GLY A 408
 None
 0.97A 5i73A-4b0nA:
0.9		 5i73A-4b0nA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b5m PUTATIVE
EXODEOXYRIBONUCLEASE

(Neisseria
meningitidis) 		PF03372
(Exo_endo_phos) 		5 ASP A  90
ALA A  70
PHE A 130
GLY A  68
LEU A  37
 None
 0.96A 5i73A-4b5mA:
undetectable		 5i73A-4b5mA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxh ELONGATION FACTOR 1A

(Oryctolagus
cuniculus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 ASP A 311
GLY A 271
GLY A 314
LEU A 233
GLY A 301
 None
 0.96A 5i73A-4cxhA:
undetectable		 5i73A-4cxhA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF13419
(HAD_2) 		6 TYR A 152
GLY A 110
GLY A 179
LEU A 180
GLY A  15
VAL A  16
 None
None
None
None
NA  A 302 ( 4.7A)
None
 1.25A 5i73A-4eelA:
undetectable		 5i73A-4eelA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fj6 GLYCOSIDE HYDROLASE
FAMILY 33, CANDIDATE
SIALIDASE

(Parabacteroides
distasonis) 		PF13859
(BNR_3)
PF14873
(BNR_assoc_N) 		5 ALA A 526
GLY A 518
GLY A 185
LEU A  33
GLY A 203
 None
 0.97A 5i73A-4fj6A:
undetectable		 5i73A-4fj6A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl0 AMINOTRANSFERASE
ALD1

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		6 ILE A 121
ALA A 120
GLY A 141
PHE A 282
GLY A 333
LEU A 334
 None
None
PLP  A 501 (-3.4A)
None
None
None
 1.32A 5i73A-4fl0A:
undetectable		 5i73A-4fl0A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 14

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		6 ALA N 372
TYR N 374
GLY N 335
LEU N 336
GLY N 244
VAL N 241
 None
 1.15A 5i73A-4heaN:
3.1		 5i73A-4heaN:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hlu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA

(Thermotoga
maritima) 		no annotation 5 ILE D1142
ALA D1143
PHE D1171
GLY D1120
VAL D1159
 None
None
None
None
ACT  D1302 (-3.4A)
 0.93A 5i73A-4hluD:
undetectable		 5i73A-4hluD:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Aneurinibacillus
thermoaerophilus) 		PF00483
(NTP_transferase) 		5 ALA A  87
PHE A  96
GLY A  98
GLY A   3
VAL A 102
 None
 0.95A 5i73A-4ho4A:
undetectable		 5i73A-4ho4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia4 AQUAPORIN

(Spinacia
oleracea) 		PF00230
(MIP) 		5 ILE A  77
ALA A  78
GLY A 149
GLY A 218
GLY A  61
 None
 0.90A 5i73A-4ia4A:
1.9		 5i73A-4ia4A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)

(Geobacillus
kaustophilus) 		PF00854
(PTR2) 		5 PHE A 382
GLY A 379
PHE A 305
GLY A 412
LEU A 414
 None
 0.97A 5i73A-4ikvA:
1.4		 5i73A-4ikvA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imi SYMPLEKIN

(Drosophila
melanogaster) 		PF11935
(DUF3453) 		5 ILE A 105
ALA A 151
GLY A 134
LEU A 138
VAL A  90
 None
 0.96A 5i73A-4imiA:
undetectable		 5i73A-4imiA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4joq ABC RIBOSE
TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Rhodobacter
sphaeroides) 		PF13407
(Peripla_BP_4) 		5 ALA A 218
GLY A 143
LEU A 154
GLY A 248
VAL A 269
 None
 0.96A 5i73A-4joqA:
undetectable		 5i73A-4joqA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m00 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		PF05345
(He_PIG) 		5 ALA A 349
PHE A 362
GLY A 361
GLY A 354
GLY A 393
 MES  A 805 ( 4.9A)
None
None
None
None
 0.98A 5i73A-4m00A:
undetectable		 5i73A-4m00A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m01 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		no annotation 5 ALA A 349
PHE A 362
GLY A 361
GLY A 354
GLY A 393
 None
 0.98A 5i73A-4m01A:
undetectable		 5i73A-4m01A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN

(Klebsiella
pneumoniae) 		PF02826
(2-Hacid_dh_C) 		5 ILE A 149
ALA A 150
GLY A 224
GLY A 141
LEU A 142
 None
None
None
CIT  A 402 ( 3.7A)
None
 0.95A 5i73A-4n18A:
undetectable		 5i73A-4n18A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III

(Scadoxus
multiflorus) 		PF00704
(Glyco_hydro_18) 		5 ILE A   5
ALA A   6
GLY A   1
GLY A 249
GLY A 271
 None
 0.93A 5i73A-4n42A:
undetectable		 5i73A-4n42A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nek ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE

(Magnetospirillum
magneticum) 		PF00378
(ECH_1) 		5 ALA A 153
GLY A 104
GLY A 159
LEU A 158
GLY A 138
 None
 0.93A 5i73A-4nekA:
undetectable		 5i73A-4nekA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A

(Burkholderia
glumae) 		PF05853
(BKACE) 		5 TYR A 136
PHE A  25
GLY A 192
GLY A 187
VAL A  55
 None
 0.94A 5i73A-4nnbA:
undetectable		 5i73A-4nnbA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsp ENDONUCLEASE V

(Homo sapiens) 		PF04493
(Endonuclease_5) 		5 ALA A 154
GLY A 143
GLY A 129
LEU A 131
GLY A  50
 None
 0.92A 5i73A-4nspA:
undetectable		 5i73A-4nspA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuh ICE-BINDING PROTEIN

(Leucosporidium) 		PF11999
(DUF3494) 		5 ALA A  65
GLY A  36
GLY A  63
GLY A  54
VAL A  52
 None
 0.97A 5i73A-4nuhA:
undetectable		 5i73A-4nuhA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7a DNA MISMATCH REPAIR
PROTEIN MLH1

(Homo sapiens) 		PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3) 		5 ILE A  32
ALA A  31
GLY A  55
LEU A 155
VAL A 194
 None
 0.98A 5i73A-4p7aA:
undetectable		 5i73A-4p7aA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF00118
(Cpn60_TCP1) 		5 ASP A 480
ILE A 455
ALA A 452
GLY A 415
GLY A  35
 ADP  A 601 (-3.9A)
ADP  A 601 (-4.3A)
None
ADP  A 601 (-3.5A)
None
 0.99A 5i73A-4pj1A:
2.7		 5i73A-4pj1A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6k BNR/ASP-BOX REPEAT
PROTEIN

(Bacteroides
caccae) 		PF13088
(BNR_2)
PF14873
(BNR_assoc_N) 		5 ALA A 546
GLY A 538
GLY A 205
LEU A  52
GLY A 223
 None
 0.96A 5i73A-4q6kA:
undetectable		 5i73A-4q6kA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 ASP A 404
ILE A 294
GLY A 274
PHE A 276
GLY A 289
 None
 0.98A 5i73A-4rbnA:
undetectable		 5i73A-4rbnA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjx HSDR

(Escherichia
coli) 		PF04313
(HSDR_N)
PF04851
(ResIII)
PF12008
(EcoR124_C) 		5 ILE A 439
PHE A 415
GLY A 416
GLY A 446
VAL A 453
 None
 0.97A 5i73A-4xjxA:
2.5		 5i73A-4xjxA:
19.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		6 ASP A  46
TYR A 123
PHE A 319
GLY A 322
GLY A 425
GLY A 480
 41U  A 605 ( 3.3A)
None
None
41U  A 605 ( 4.1A)
41U  A 605 ( 3.7A)
None
 0.42A 5i73A-4xnuA:
54.4		 5i73A-4xnuA:
53.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		6 TYR A 165
ILE C 154
ALA C 209
PHE C  79
GLY C 129
GLY C 156
 None
 1.45A 5i73A-4yfaA:
undetectable		 5i73A-4yfaA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 537
ALA A 536
TYR A 492
GLY A 526
GLY A 608
 None
 0.93A 5i73A-4yffA:
2.2		 5i73A-4yffA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azd BACTERIORHODOPSIN

(Thermus
thermophilus) 		PF01036
(Bac_rhodopsin) 		6 ILE A 174
ALA A 173
GLY A 188
LEU A 121
GLY A 180
VAL A 183
 None
 1.32A 5i73A-5azdA:
2.3		 5i73A-5azdA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fzp DISPASE
AUTOLYSIS-INDUCING
PROTEIN

(Streptomyces
mobaraensis) 		no annotation 5 ALA A 220
GLY A 140
GLY A 185
LEU A 217
GLY A 127
 None
 0.96A 5i73A-5fzpA:
undetectable		 5i73A-5fzpA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B

(Homo sapiens) 		no annotation 5 ILE A 829
ALA A 828
GLY A 862
LEU A 797
GLY A 883
 None
 0.96A 5i73A-5hdtA:
2.6		 5i73A-5hdtA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG

(Oryza sativa) 		no annotation 5 ASP B 397
ILE B 403
ALA B 402
LEU B 373
GLY B 383
 None
 0.87A 5i73A-5hzgB:
undetectable		 5i73A-5hzgB:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER

(Homo sapiens) 		PF00209
(SNF) 		12 TYR A  95
ASP A  98
ILE A 172
ALA A 173
TYR A 175
PHE A 335
GLY A 338
PHE A 341
GLY A 442
LEU A 443
GLY A 498
VAL A 501
 None
 0.47A 5i73A-5i6zA:
61.3		 5i73A-5i6zA:
99.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Caenorhabditis
elegans) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		6 ILE A 291
ALA A 213
PHE A 327
GLY A 317
GLY A 139
GLY A 296
 None
 1.04A 5i73A-5kgnA:
undetectable		 5i73A-5kgnA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis) 		PF00290
(Trp_syntA) 		5 GLY A 173
GLY A  99
LEU A  51
GLY A 231
VAL A 210
 None
 0.86A 5i73A-5kzmA:
undetectable		 5i73A-5kzmA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis) 		PF00290
(Trp_syntA) 		5 ILE A  21
GLY A 173
GLY A  99
LEU A  51
VAL A 210
 None
 0.77A 5i73A-5kzmA:
undetectable		 5i73A-5kzmA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 ASP A 250
ILE A 291
GLY A 357
PHE A 347
GLY A 272
 None
 0.94A 5i73A-5kzsA:
undetectable		 5i73A-5kzsA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ntf AMINOPEPTIDASE

(Trypanosoma
cruzi) 		PF00883
(Peptidase_M17) 		5 ALA A 399
GLY A 295
GLY A 373
LEU A 377
GLY A 307
 None
None
SO4  A 601 (-3.0A)
None
None
 0.90A 5i73A-5ntfA:
undetectable		 5i73A-5ntfA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9p GLUCONATE
5-DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		5 ILE A  39
ALA A  15
GLY A  60
GLY A  36
LEU A  10
 None
 0.90A 5i73A-5u9pA:
undetectable		 5i73A-5u9pA:
18.30