SIMILAR PATTERNS OF AMINO ACIDS FOR 5I71_A_68PA701_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)

(Thermotoga
maritima) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 GLY A 185
GLY A 178
LEU A 204
GLY A  91
VAL A 190
 None
 0.81A 5i71A-1c3cA:
undetectable		 5i71A-1c3cA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elj MALTODEXTRIN-BINDING
PROTEIN

(Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		5 ILE A 352
ALA A 351
PHE A 197
LEU A 368
GLY A 208
 None
 1.33A 5i71A-1eljA:
undetectable		 5i71A-1eljA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5q GAMMA HERPESVIRUS
CYCLIN

(Murid
gammaherpesvirus
4) 		PF00134
(Cyclin_N) 		5 ALA B  75
PHE B  44
LEU B 182
GLY B  37
VAL B  40
 None
 1.19A 5i71A-1f5qB:
0.0		 5i71A-1f5qB:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE

(Sus scrofa) 		PF00342
(PGI) 		5 ILE A 490
ALA A 491
GLY A 298
GLY A 162
VAL A 166
 None
 1.22A 5i71A-1gzvA:
0.0		 5i71A-1gzvA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jji CARBOXYLESTERASE

(Archaeoglobus
fulgidus) 		PF07859
(Abhydrolase_3) 		5 TYR A  16
ILE A  36
ALA A  35
TYR A  32
GLY A  88
 None
None
None
None
EPE  A 455 (-3.7A)
 0.93A 5i71A-1jjiA:
undetectable		 5i71A-1jjiA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka0 HALOTOLERANCE
PROTEIN HAL2

(Saccharomyces
cerevisiae) 		PF00459
(Inositol_P) 		5 ILE A 220
GLY A 307
GLY A 274
LEU A 275
GLY A 205
 None
 1.22A 5i71A-1ka0A:
0.0		 5i71A-1ka0A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp0 CREATINE
AMIDINOHYDROLASE

(Actinobacillus) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 ILE A 184
ALA A 181
GLY A 242
GLY A 187
VAL A 239
 None
 0.98A 5i71A-1kp0A:
0.0		 5i71A-1kp0A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhs PLASMA MEMBRANE
ATPASE

(Neurospora
crassa) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		5 ILE A 696
GLY A 294
GLY A 757
LEU A 761
GLY A 333
 None
 1.22A 5i71A-1mhsA:
2.6		 5i71A-1mhsA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mq7 DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Mycobacterium
tuberculosis) 		PF00692
(dUTPase) 		5 ILE A  90
ALA A  50
GLY A  48
GLY A  80
VAL A  61
 None
 1.30A 5i71A-1mq7A:
undetectable		 5i71A-1mq7A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvd PYRUVATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ALA A 425
GLY A  84
GLY A 420
GLY A  94
VAL A  95
 None
 0.94A 5i71A-1pvdA:
0.0		 5i71A-1pvdA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q50 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00342
(PGI) 		5 ILE A 541
ALA A 542
GLY A 351
GLY A 210
VAL A 214
 None
 1.07A 5i71A-1q50A:
undetectable		 5i71A-1q50A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE

(Escherichia
coli) 		PF01156
(IU_nuc_hydro) 		5 ILE A  20
ALA A  17
LEU A 215
GLY A  33
VAL A  61
 None
 1.06A 5i71A-1q8fA:
undetectable		 5i71A-1q8fA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))

(Sulfolobus
solfataricus) 		PF00117
(GATase) 		5 ILE B  17
ALA B  18
GLY B  54
GLY B  82
VAL B  83
 None
 1.18A 5i71A-1qdlB:
undetectable		 5i71A-1qdlB:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG

(Homo sapiens) 		PF08423
(Rad51) 		5 ILE A 101
GLY A 149
GLY A 114
LEU A 112
GLY A 153
 None
 1.12A 5i71A-1v5wA:
undetectable		 5i71A-1v5wA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG

(Bacillus
subtilis) 		PF05343
(Peptidase_M42) 		5 ALA A  52
PHE A 234
GLY A 235
GLY A 210
LEU A  50
 None
 1.03A 5i71A-1vheA:
0.4		 5i71A-1vheA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 ASP A 590
ILE A 571
GLY A 555
LEU A 558
GLY A 582
 None
 1.10A 5i71A-1yr2A:
undetectable		 5i71A-1yr2A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b67 COG0778:
NITROREDUCTASE

(Streptococcus
pneumoniae) 		PF00881
(Nitroreductase) 		5 ILE A  76
ALA A  77
GLY A 180
LEU A  57
VAL A  26
 None
 0.98A 5i71A-2b67A:
undetectable		 5i71A-2b67A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1c CARBOXYPEPTIDASE B

(Helicoverpa zea) 		PF00246
(Peptidase_M14) 		5 ILE A 202
TYR A 269
GLY A 218
GLY A 241
GLY A 300
 None
 1.20A 5i71A-2c1cA:
undetectable		 5i71A-2c1cA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE

(Mus musculus) 		PF00342
(PGI) 		5 ILE A 491
ALA A 492
GLY A 299
GLY A 163
VAL A 167
 None
 1.20A 5i71A-2cxnA:
undetectable		 5i71A-2cxnA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00202
(Aminotran_3) 		5 PHE A 139
GLY A 223
GLY A 257
LEU A 258
GLY A 141
 PLP  A1001 ( 4.9A)
None
None
None
PLP  A1001 ( 4.2A)
 1.30A 5i71A-2eo5A:
undetectable		 5i71A-2eo5A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdr GLUTATHIONE
S-TRANSFERASE

(Paraburkholderia
xenovorans) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		5 TYR A 167
ILE A 201
PHE A 159
GLY A 163
GLY A 186
 None
 1.33A 5i71A-2gdrA:
1.9		 5i71A-2gdrA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE

(Shewanella
oneidensis) 		PF00920
(ILVD_EDD) 		5 ALA A 334
PHE A 223
GLY A 219
GLY A 352
LEU A 356
 None
 0.96A 5i71A-2gp4A:
undetectable		 5i71A-2gp4A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		5 ILE A 738
ALA A 681
GLY A 679
LEU A 721
GLY A 559
 None
 1.17A 5i71A-2hg4A:
undetectable		 5i71A-2hg4A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Pyrococcus
furiosus) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 ILE A 136
GLY A 158
GLY A 164
LEU A 163
GLY A 289
 None
None
None
None
PCP  A 392 (-3.3A)
 1.21A 5i71A-2i14A:
undetectable		 5i71A-2i14A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p13 CBS DOMAIN

(Nitrosomonas
europaea) 		PF03471
(CorC_HlyC) 		5 ILE A 499
ALA A 486
GLY A 481
PHE A 480
GLY A 473
 None
 1.15A 5i71A-2p13A:
undetectable		 5i71A-2p13A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ILE A 747
ALA A 690
GLY A 688
LEU A 730
GLY A 567
 None
 1.16A 5i71A-2qo3A:
undetectable		 5i71A-2qo3A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqx METALLOPROTEINASE

(Serratia
proteamaculans) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
PF16485
(PLN_propep) 		5 TYR A 236
ILE A 149
GLY A 242
LEU A 216
GLY A  22
 None
 1.12A 5i71A-2vqxA:
undetectable		 5i71A-2vqxA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8u CHITIN DEACETYLASE

(Aspergillus
nidulans) 		PF01522
(Polysacc_deac_1) 		5 ILE A  42
ALA A 221
PHE A 182
LEU A 211
GLY A 189
 None
 1.23A 5i71A-2y8uA:
undetectable		 5i71A-2y8uA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		5 ILE A 160
ALA A 159
TYR A 156
GLY A 211
GLY A 164
 None
 1.35A 5i71A-2yevA:
0.0		 5i71A-2yevA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yij PHOSPHOLIPASE
A1-IIGAMMA

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		5 ILE A 232
ALA A 269
GLY A 131
GLY A 234
VAL A 212
 None
 1.05A 5i71A-2yijA:
undetectable		 5i71A-2yijA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agr NUCLEOSIDE
TRIPHOSPHATE
HYDROLASE

(Neospora
caninum) 		PF01150
(GDA1_CD39) 		5 ILE A  42
ALA A  41
GLY A 577
LEU A  79
VAL A 583
 None
 1.20A 5i71A-3agrA:
0.6		 5i71A-3agrA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayd GALECTIN-3

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 ASP A 215
ILE A 200
PHE A 192
LEU A 219
GLY A 136
 None
 1.12A 5i71A-3aydA:
undetectable		 5i71A-3aydA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		5 ILE A 253
ALA A 254
TYR A 257
GLY A  79
VAL A 203
 None
 1.04A 5i71A-3dqzA:
undetectable		 5i71A-3dqzA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebv CHINITASE A

(Streptomyces
coelicolor) 		PF00704
(Glyco_hydro_18) 		5 ILE A 118
TYR A 162
GLY A  45
PHE A 100
GLY A  83
 None
 1.11A 5i71A-3ebvA:
undetectable		 5i71A-3ebvA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 ILE A 824
ALA A 839
GLY A 522
GLY A 798
GLY A 480
 None
 1.17A 5i71A-3ecqA:
undetectable		 5i71A-3ecqA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs3 SYMPLEKIN

(Drosophila
melanogaster) 		PF11935
(DUF3453) 		5 ILE A 105
ALA A 151
GLY A 134
LEU A 138
VAL A  90
 None
 0.99A 5i71A-3gs3A:
1.4		 5i71A-3gs3A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE

(Vibrio cholerae) 		PF00342
(PGI) 		5 ILE A 487
ALA A 488
GLY A 297
GLY A 162
VAL A 166
 None
 1.16A 5i71A-3hjbA:
undetectable		 5i71A-3hjbA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5t AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00202
(Aminotran_3) 		5 ILE A 103
ALA A 104
GLY A 263
PHE A 286
VAL A 290
 None
 1.27A 5i71A-3i5tA:
undetectable		 5i71A-3i5tA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i93 DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Mycobacterium
tuberculosis) 		PF00692
(dUTPase) 		5 ILE A  90
ALA A  50
GLY A  48
GLY A  80
VAL A  61
 DUP  A 201 (-4.7A)
None
None
DUP  A 201 (-3.4A)
DUP  A 201 ( 4.8A)
 1.30A 5i71A-3i93A:
undetectable		 5i71A-3i93A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iau THREONINE DEAMINASE

(Solanum
lycopersicum) 		PF00291
(PALP) 		5 ILE A 342
ALA A 343
GLY A 220
GLY A 199
VAL A 225
 None
None
LLP  A  91 ( 3.4A)
None
None
 1.23A 5i71A-3iauA:
undetectable		 5i71A-3iauA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9i BH0479 PROTEIN

(Bacillus
halodurans) 		PF12688
(TPR_5) 		5 ILE A  64
ALA A  65
GLY A  70
GLY A  67
GLY A 100
 None
 1.28A 5i71A-3k9iA:
undetectable		 5i71A-3k9iA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4e UNCHARACTERIZED
PEPTIDASE LMO0363

(Listeria
monocytogenes) 		PF03575
(Peptidase_S51) 		5 ASP A 136
ILE A 124
ALA A 149
GLY A 117
VAL A  84
 SO4  A 207 ( 4.8A)
None
None
None
None
 0.97A 5i71A-3l4eA:
undetectable		 5i71A-3l4eA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbu GLUCOSE-6-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00342
(PGI) 		5 ILE A 486
ALA A 487
GLY A 296
GLY A 161
VAL A 165
 None
 1.16A 5i71A-3nbuA:
undetectable		 5i71A-3nbuA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pig BETA-FRUCTOFURANOSID
ASE

(Bifidobacterium
longum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 ILE A 395
GLY A 424
GLY A 406
LEU A 407
GLY A 456
 None
 1.35A 5i71A-3pigA:
undetectable		 5i71A-3pigA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqv RCL1 PROTEIN

(Kluyveromyces
lactis) 		PF01137
(RTC)
PF05189
(RTC_insert) 		5 ALA A 127
GLY A 192
GLY A 135
LEU A 136
GLY A 241
 None
PEG  A 410 ( 4.8A)
None
None
None
 1.20A 5i71A-3pqvA:
undetectable		 5i71A-3pqvA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Francisella
tularensis) 		PF00342
(PGI) 		5 ILE A 477
ALA A 478
GLY A 287
GLY A 151
VAL A 155
 None
 1.15A 5i71A-3q88A:
undetectable		 5i71A-3q88A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tnl SHIKIMATE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF08501
(Shikimate_dh_N) 		5 ILE A  80
PHE A  62
GLY A  69
GLY A 109
LEU A  87
 None
 0.93A 5i71A-3tnlA:
undetectable		 5i71A-3tnlA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujz METALLOPROTEASE STCE

(Escherichia
coli) 		PF10462
(Peptidase_M66) 		5 TYR A 713
ALA A 387
PHE A 551
GLY A 714
VAL A 406
 None
 1.15A 5i71A-3ujzA:
undetectable		 5i71A-3ujzA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuq TRANSCRIPTIONAL
REGULATOR (TETR/ACRR
FAMILY)

(Thermus
thermophilus) 		PF00440
(TetR_N) 		5 ILE A 159
ALA A 160
PHE A  86
GLY A 140
LEU A 130
 None
 0.87A 5i71A-3vuqA:
undetectable		 5i71A-3vuqA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		5 ILE A1001
ALA A1000
GLY A 983
GLY A 397
VAL A 399
 None
 1.06A 5i71A-3w9iA:
undetectable		 5i71A-3w9iA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aej COLLAGEN
ALPHA-1(III) CHAIN

(Homo sapiens) 		PF01410
(COLFI) 		5 ILE A 223
ALA A 224
PHE A 117
GLY A 108
VAL A 239
 None
 1.06A 5i71A-4aejA:
undetectable		 5i71A-4aejA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ao7 ESTERASE

(unidentified) 		PF12146
(Hydrolase_4) 		5 ILE A  62
TYR A  61
GLY A 150
LEU A  69
GLY A  52
 None
 1.32A 5i71A-4ao7A:
undetectable		 5i71A-4ao7A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aqq L2 PROTEIN III
(PENTON BASE)

(Human
mastadenovirus
B) 		PF01686
(Adeno_Penton_B) 		5 ILE A 197
ALA A 196
PHE A 219
LEU A 179
GLY A 216
 None
 1.17A 5i71A-4aqqA:
undetectable		 5i71A-4aqqA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		5 PHE A1997
GLY A2017
LEU A1949
GLY A2011
VAL A2022
 None
 1.12A 5i71A-4asiA:
undetectable		 5i71A-4asiA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bo6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG

(Pseudomonas
aeruginosa) 		PF13561
(adh_short_C2) 		5 ILE A 218
ALA A 219
GLY A  18
GLY A 185
VAL A 142
 None
 1.26A 5i71A-4bo6A:
undetectable		 5i71A-4bo6A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1k TRIOSEPHOSPHATE
ISOMERASE

(Burkholderia
thailandensis) 		PF00121
(TIM) 		5 ILE A  42
ALA A  41
PHE A 243
GLY A  32
VAL A  29
 None
 1.12A 5i71A-4g1kA:
undetectable		 5i71A-4g1kA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Aneurinibacillus
thermoaerophilus) 		PF00483
(NTP_transferase) 		5 ALA A  87
PHE A  96
GLY A  98
GLY A   3
VAL A 102
 None
 1.01A 5i71A-4ho4A:
undetectable		 5i71A-4ho4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1y COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 ILE A 567
ALA A 585
GLY A 462
GLY A 569
GLY A 651
 None
 1.13A 5i71A-4j1yA:
undetectable		 5i71A-4j1yA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA

(Bacillus
subtilis) 		PF01041
(DegT_DnrJ_EryC1) 		5 ASP A 296
GLY A 253
GLY A 303
LEU A 304
GLY A 125
 None
None
None
None
LLP  A 247 ( 3.2A)
 1.05A 5i71A-4k2bA:
undetectable		 5i71A-4k2bA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 TYR A 454
ILE A 570
ALA A 569
GLY A 492
VAL A 608
 None
 1.27A 5i71A-4k6mA:
undetectable		 5i71A-4k6mA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m00 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		PF05345
(He_PIG) 		5 ALA A 349
PHE A 362
GLY A 361
GLY A 354
GLY A 393
 MES  A 805 ( 4.9A)
None
None
None
None
 0.94A 5i71A-4m00A:
undetectable		 5i71A-4m00A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m01 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		no annotation 5 ALA A 349
PHE A 362
GLY A 361
GLY A 354
GLY A 393
 None
 0.94A 5i71A-4m01A:
undetectable		 5i71A-4m01A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mc0 PUTATIVE
SESQUITERPENE
CYCLASE

(Kitasatospora
setae) 		no annotation 5 ILE A 217
GLY A  56
GLY A 305
LEU A 307
GLY A 180
 None
 1.22A 5i71A-4mc0A:
1.8		 5i71A-4mc0A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mck CHITINASE

(Zea mays) 		PF00182
(Glyco_hydro_19) 		5 ILE A  52
ALA A  53
GLY A  38
PHE A  39
VAL A  33
 None
 1.25A 5i71A-4mckA:
undetectable		 5i71A-4mckA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF01425
(Amidase) 		5 ASP A 187
PHE A 100
GLY A 101
GLY A 148
LEU A 147
 None
 1.01A 5i71A-4n0iA:
undetectable		 5i71A-4n0iA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A

(Burkholderia
glumae) 		PF05853
(BKACE) 		5 TYR A 136
PHE A  25
GLY A 192
GLY A 187
VAL A  55
 None
 0.96A 5i71A-4nnbA:
undetectable		 5i71A-4nnbA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7a DNA MISMATCH REPAIR
PROTEIN MLH1

(Homo sapiens) 		PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3) 		5 ILE A  32
ALA A  31
GLY A  55
LEU A 155
VAL A 194
 None
 1.01A 5i71A-4p7aA:
undetectable		 5i71A-4p7aA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyt UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(unidentified) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		5 ALA A  62
GLY A  64
LEU A  83
GLY A 300
VAL A  71
 FAD  A 401 (-4.1A)
FAD  A 401 (-3.5A)
FAD  A 401 (-3.9A)
None
None
 1.37A 5i71A-4pytA:
undetectable		 5i71A-4pytA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9g MBP1

(Caldanaerobius
polysaccharolyticus) 		PF13416
(SBP_bac_8) 		5 ASP A 305
ILE A 344
ALA A 345
GLY A 270
VAL A 365
 BMA  A 502 ( 4.7A)
None
None
None
None
 1.05A 5i71A-4r9gA:
undetectable		 5i71A-4r9gA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4utg SUGAR KINASE

(Burkholderia
pseudomallei) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 GLY A 160
GLY A 117
LEU A  12
GLY A  18
VAL A  34
 None
ANP  A 399 ( 3.5A)
None
CL  A 401 (-4.4A)
None
 1.27A 5i71A-4utgA:
undetectable		 5i71A-4utgA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE

(Colias
eurytheme) 		PF00342
(PGI) 		5 ILE A 494
ALA A 495
GLY A 302
GLY A 167
VAL A 171
 None
 1.18A 5i71A-4wmjA:
undetectable		 5i71A-4wmjA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wut ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)

(Agrobacterium
vitis) 		PF13407
(Peripla_BP_4) 		5 ILE A 215
ALA A 241
GLY A 187
GLY A 217
VAL A 205
 None
 1.06A 5i71A-4wutA:
undetectable		 5i71A-4wutA:
20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		6 ASP A  46
TYR A 123
PHE A 319
GLY A 322
GLY A 425
GLY A 480
 41U  A 605 ( 3.3A)
None
None
41U  A 605 ( 4.1A)
41U  A 605 ( 3.7A)
None
 0.36A 5i71A-4xnuA:
53.8		 5i71A-4xnuA:
53.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4q SORTASE, SRTB FAMILY

(Streptococcus
pneumoniae) 		PF04203
(Sortase) 		5 ILE A  99
TYR A 101
PHE A 161
LEU A 184
GLY A 156
 None
 1.11A 5i71A-4y4qA:
undetectable		 5i71A-4y4qA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 537
ALA A 536
TYR A 492
GLY A 526
GLY A 608
 None
 0.90A 5i71A-4yffA:
undetectable		 5i71A-4yffA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3y BENZOYL-COA
REDUCTASE, PUTATIVE

(Geobacter
metallireducens) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 TYR A 546
GLY A  96
GLY A  65
LEU A  66
GLY A 536
 None
MTE  A 702 (-3.0A)
None
None
SF4  A 701 ( 4.3A)
 1.22A 5i71A-4z3yA:
undetectable		 5i71A-4z3yA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I

(Oryctolagus
cuniculus) 		PF00400
(WD40) 		5 ALA I  88
PHE I 108
LEU I 136
GLY I  70
VAL I  99
 None
 1.36A 5i71A-5a5uI:
undetectable		 5i71A-5a5uI:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azd BACTERIORHODOPSIN

(Thermus
thermophilus) 		PF01036
(Bac_rhodopsin) 		5 ILE A 174
ALA A 173
LEU A 121
GLY A 180
VAL A 183
 None
 1.24A 5i71A-5azdA:
undetectable		 5i71A-5azdA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA PRIMASE LARGE
SUBUNIT

(Homo sapiens) 		PF04104
(DNA_primase_lrg) 		5 ASP B 361
ILE B 349
GLY B 310
LEU B 313
GLY B 344
 None
 1.17A 5i71A-5exrB:
undetectable		 5i71A-5exrB:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqt NITRILE-SPECIFIER
PROTEIN 1

(Arabidopsis
thaliana) 		PF01344
(Kelch_1)
PF01419
(Jacalin)
PF13415
(Kelch_3) 		5 ILE A 171
ALA A 172
GLY A 183
LEU A 231
GLY A 450
 None
 1.15A 5i71A-5gqtA:
undetectable		 5i71A-5gqtA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9p GALECTIN-3

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 ASP A 215
ILE A 200
PHE A 192
LEU A 219
GLY A 136
 None
 1.08A 5i71A-5h9pA:
undetectable		 5i71A-5h9pA:
13.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER

(Homo sapiens) 		PF00209
(SNF) 		12 TYR A  95
ASP A  98
ILE A 172
ALA A 173
TYR A 175
PHE A 335
GLY A 338
PHE A 341
GLY A 442
LEU A 443
GLY A 498
VAL A 501
 None
 0.40A 5i71A-5i6zA:
60.5		 5i71A-5i6zA:
99.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ibx TRIOSEPHOSPHATE
ISOMERASE

(Streptococcus
pneumoniae) 		PF00121
(TIM) 		5 GLY A 231
PHE A   6
GLY A  40
LEU A  60
VAL A 164
 None
 1.29A 5i71A-5ibxA:
undetectable		 5i71A-5ibxA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE

(Mycolicibacterium
thermoresistibile) 		PF00982
(Glyco_transf_20) 		5 GLY A 203
PHE A 207
LEU A 214
GLY A 231
VAL A 242
 None
 1.22A 5i71A-5jijA:
undetectable		 5i71A-5jijA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Caenorhabditis
elegans) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 ILE A 291
ALA A 213
PHE A 327
GLY A 317
GLY A 139
 None
 0.99A 5i71A-5kgnA:
undetectable		 5i71A-5kgnA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Caenorhabditis
elegans) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 ILE A 291
PHE A 327
GLY A 317
GLY A 139
GLY A 296
 None
 1.10A 5i71A-5kgnA:
undetectable		 5i71A-5kgnA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis) 		PF00290
(Trp_syntA) 		5 GLY A 173
GLY A  99
LEU A  51
GLY A 231
VAL A 210
 None
 0.84A 5i71A-5kzmA:
undetectable		 5i71A-5kzmA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis) 		PF00290
(Trp_syntA) 		5 ILE A  21
GLY A 173
GLY A  99
LEU A  51
VAL A 210
 None
 0.81A 5i71A-5kzmA:
undetectable		 5i71A-5kzmA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 ASP A 250
ILE A 291
GLY A 357
PHE A 347
GLY A 272
 None
 0.98A 5i71A-5kzsA:
undetectable		 5i71A-5kzsA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mf1 FUSION PROTEIN
HAP2/GCS1

(Chlamydomonas
reinhardtii) 		PF10699
(HAP2-GCS1) 		5 ALA A 473
PHE A 477
GLY A 409
GLY A 484
GLY A 421
 NAG  A1001 (-4.0A)
None
None
None
None
 1.32A 5i71A-5mf1A:
undetectable		 5i71A-5mf1A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME

(Lysobacter sp.
XL1) 		no annotation 5 ALA A  36
GLY A 150
LEU A 163
GLY A  56
VAL A  48
 None
None
None
FMT  A 303 ( 4.4A)
None
 1.22A 5i71A-5mrtA:
undetectable		 5i71A-5mrtA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfb GALECTIN-3

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 ASP A 215
ILE A 200
PHE A 192
LEU A 219
GLY A 136
 None
 1.04A 5i71A-5nfbA:
undetectable		 5i71A-5nfbA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile) 		no annotation 5 ILE C 245
TYR C 361
GLY C 240
GLY C  83
VAL C  72
 None
 1.09A 5i71A-5ol2C:
undetectable		 5i71A-5ol2C:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oy0 PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI

(Synechocystis
sp. PCC 6803) 		no annotation 5 ILE 0  62
ALA 0 135
GLY 0  69
GLY 0  84
LEU 0  86
 None
None
CLA  1 833 ( 4.2A)
None
None
 1.26A 5i71A-5oy00:
undetectable		 5i71A-5oy00:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)

(Corynebacterium
freiburgense) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 TYR A 904
ALA A 878
GLY A 602
PHE A 561
GLY A 900
 None
SO4  A2003 (-3.4A)
None
None
None
 1.28A 5i71A-5ux5A:
undetectable		 5i71A-5ux5A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v3s TWO-COMPONENT
INSECTICIDAL PROTEIN
16 KDA UNIT

(Alcaligenes
faecalis) 		PF06355
(Aegerolysin) 		5 TYR A 100
ASP A 111
GLY A  85
LEU A  38
GLY A 107
 None
 1.12A 5i71A-5v3sA:
undetectable		 5i71A-5v3sA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfm ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 GLY A 302
GLY A 404
LEU A 433
GLY A 360
VAL A 361
 None
 1.33A 5i71A-5xfmA:
undetectable		 5i71A-5xfmA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0u NEOPULLULANASE 1

(Thermoactinomyces
vulgaris) 		no annotation 5 TYR A 570
GLY A 419
PHE A 420
GLY A 499
VAL A 424
 None
 1.22A 5i71A-5z0uA:
undetectable		 5i71A-5z0uA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzc GLUCOSE-6-PHOSPHATE
ISOMERASE

(Elizabethkingia
anophelis) 		no annotation 5 ILE A 485
ALA A 486
GLY A 295
GLY A 161
VAL A 165
 None
 1.17A 5i71A-6bzcA:
undetectable		 5i71A-6bzcA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsf GTPASE-ACTIVATING
PROTEIN BEM3

(Saccharomyces
cerevisiae) 		no annotation 5 ILE A 537
ALA A 536
PHE A 512
GLY A 513
VAL A 507
 None
 0.79A 5i71A-6fsfA:
undetectable		 5i71A-6fsfA:
9.67