SIMILAR PATTERNS OF AMINO ACIDS FOR 5I6X_A_8PRA705_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aos ARGININOSUCCINATE
LYASE

(Homo sapiens) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		5 TYR A  45
ALA A  52
GLY A 110
SER A  46
GLY A  48
 None
 1.07A 5i6xA-1aosA:
0.0		 5i6xA-1aosA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b33 ALLOPHYCOCYANIN,
ALPHA CHAIN

(Mastigocladus
laminosus) 		PF00502
(Phycobilisome) 		5 TYR A  87
ASP A  83
ALA A 160
ILE A 122
GLY A 107
 BLA  A 201 (-4.2A)
BLA  A 201 (-2.8A)
None
None
BLA  A 201 ( 4.0A)
 1.12A 5i6xA-1b33A:
0.8		 5i6xA-1b33A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTM, FLAVOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 ALA C 117
ILE C 116
GLY C 151
PHE C 152
GLY C 119
 FAD  C1922 (-3.2A)
None
None
None
None
 1.17A 5i6xA-1ffvC:
2.2		 5i6xA-1ffvC:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F

(Escherichia
coli) 		PF00267
(Porin_1) 		5 ALA A 251
ILE A 240
GLY A 285
GLY A 206
VAL A 289
 None
 1.18A 5i6xA-1gfnA:
undetectable		 5i6xA-1gfnA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpp ENDONUCLEASE PI-SCEI

(Saccharomyces
cerevisiae) 		PF05203
(Hom_end_hint) 		5 ALA A  -1
ILE A 434
GLY A  29
PHE A 444
SER A 437
 None
 1.23A 5i6xA-1gppA:
undetectable		 5i6xA-1gppA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpp ENDONUCLEASE PI-SCEI

(Saccharomyces
cerevisiae) 		PF05203
(Hom_end_hint) 		5 ALA A  -1
ILE A 434
PHE A 444
SER A 437
VAL A   8
 None
 1.02A 5i6xA-1gppA:
undetectable		 5i6xA-1gppA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h74 HOMOSERINE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ALA A 108
ILE A 109
GLY A  65
GLY A 104
VAL A  81
 None
 1.08A 5i6xA-1h74A:
undetectable		 5i6xA-1h74A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcu ALPHA-1,2-MANNOSIDAS
E

(Trichoderma
reesei) 		PF01532
(Glyco_hydro_47) 		5 ALA A  65
ILE A  73
PHE A  23
SER A  57
GLY A  61
 None
 1.13A 5i6xA-1hcuA:
0.0		 5i6xA-1hcuA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpg GLUTAMIC ACID
SPECIFIC PROTEASE

(Streptomyces
griseus) 		no annotation 5 ILE A  31
GLY A 104
SER A 195
GLY A 197
VAL A 106
 None
 1.19A 5i6xA-1hpgA:
undetectable		 5i6xA-1hpgA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqs ISOCITRATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00180
(Iso_dh) 		5 TYR A 124
PHE A 399
SER A 130
GLY A 322
VAL A 395
 None
 1.20A 5i6xA-1hqsA:
0.0		 5i6xA-1hqsA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1is7 GTP CYCLOHYDROLASE I

(Rattus
norvegicus) 		PF01227
(GTP_cyclohydroI) 		5 ALA A 181
ILE A 184
TYR A 147
GLY A 194
VAL A 163
 None
 1.11A 5i6xA-1is7A:
1.0		 5i6xA-1is7A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy9 SPERMIDINE SYNTHASE

(Bacillus
subtilis) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 ALA A 177
ILE A 176
PHE A 211
GLY A 184
VAL A 207
 None
 1.02A 5i6xA-1iy9A:
undetectable		 5i6xA-1iy9A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7j PROTEIN YCIO

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC) 		5 ASP A 156
ALA A  39
GLY A 174
SER A 155
GLY A  37
 None
 1.15A 5i6xA-1k7jA:
0.0		 5i6xA-1k7jA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mz5 SIALIDASE

(Trypanosoma
rangeli) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		5 ASP A 214
ALA A 183
ILE A 101
TYR A 108
GLY A 189
 None
 1.17A 5i6xA-1mz5A:
undetectable		 5i6xA-1mz5A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pho PHOSPHOPORIN

(Escherichia
coli) 		PF00267
(Porin_1) 		5 ALA A 251
ILE A 240
GLY A 285
SER A 204
GLY A 206
 None
 1.09A 5i6xA-1phoA:
undetectable		 5i6xA-1phoA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyr HIGH LEVEL
KASUGAMYCIN
RESISTANCE PROTEIN

(Escherichia
coli) 		PF00398
(RrnaAD) 		5 ALA A  92
ILE A  65
TYR A  88
PHE A  97
VAL A 110
 None
 1.14A 5i6xA-1qyrA:
undetectable		 5i6xA-1qyrA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE

(Fervidobacterium
pennivorans) 		PF00082
(Peptidase_S8) 		5 ALA A 519
ILE A 528
GLY A 659
PHE A 658
VAL A 672
 None
 1.08A 5i6xA-1r6vA:
undetectable		 5i6xA-1r6vA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 ASP A 447
TYR A 157
GLY A 638
GLY A 444
VAL A 624
 None
 1.15A 5i6xA-1r8wA:
undetectable		 5i6xA-1r8wA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh9 ENDO-BETA-MANNANASE

(Solanum
lycopersicum) 		PF00150
(Cellulase) 		5 ILE A 388
GLY A 320
PHE A 359
GLY A  51
VAL A 376
 None
 1.25A 5i6xA-1rh9A:
undetectable		 5i6xA-1rh9A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg3 ALLANTOICASE

(Saccharomyces
cerevisiae) 		PF03561
(Allantoicase) 		5 ASP A  24
ALA A 117
ILE A 165
GLY A  97
VAL A 138
 None
 1.03A 5i6xA-1sg3A:
undetectable		 5i6xA-1sg3A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgq STREPTOMYCES GRISEUS
PROTEINASE B

(Streptomyces
griseus) 		PF00089
(Trypsin) 		5 ILE E  31
GLY E 104
SER E 195
GLY E 197
VAL E 106
 None
 1.13A 5i6xA-1sgqE:
undetectable		 5i6xA-1sgqE:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495

(Pyrococcus
horikoshii) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		5 ALA A 112
ILE A  54
GLY A 133
PHE A 137
VAL A  79
 None
None
SO4  A 505 (-4.0A)
None
None
 1.14A 5i6xA-1x3lA:
undetectable		 5i6xA-1x3lA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xru 4-DEOXY-L-THREO-5-HE
XOSULOSE-URONATE
KETOL-ISOMERASE

(Escherichia
coli) 		PF04962
(KduI) 		5 ALA A 103
ILE A  81
TYR A 127
PHE A 167
GLY A  79
 None
 1.09A 5i6xA-1xruA:
undetectable		 5i6xA-1xruA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4u CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 ALA A  98
ILE A  97
PHE A 131
GLY A 101
VAL A 137
 None
 1.19A 5i6xA-1y4uA:
0.7		 5i6xA-1y4uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrz XYLAN
BETA-1,4-XYLOSIDASE

(Bacillus
halodurans) 		PF04616
(Glyco_hydro_43) 		5 TYR A1026
ASP A1046
ALA A1264
ILE A1284
SER A1044
 None
 1.26A 5i6xA-1yrzA:
undetectable		 5i6xA-1yrzA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvk HYPOTHETICAL PROTEIN
BSU33890

(Bacillus
subtilis) 		PF00583
(Acetyltransf_1) 		5 ASP A  87
ALA A  70
ILE A  69
TYR A  54
GLY A  52
 None
COA  A 201 (-3.6A)
COA  A 201 (-4.5A)
None
None
 1.25A 5i6xA-1yvkA:
undetectable		 5i6xA-1yvkA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlp PETAL DEATH PROTEIN

(Dianthus
caryophyllus) 		PF13714
(PEP_mutase) 		5 ASP A 137
ALA A 163
ILE A 162
TYR A 198
VAL A 118
 None
 1.22A 5i6xA-1zlpA:
undetectable		 5i6xA-1zlpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459) 		5 ALA A 167
TYR A 189
GLY A 171
GLY A 176
VAL A 100
 None
 1.20A 5i6xA-2bxyA:
undetectable		 5i6xA-2bxyA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dua PHOSPHONOPYRUVATE
HYDROLASE

(Variovorax sp.
Pal2) 		PF13714
(PEP_mutase) 		5 ALA A 139
ILE A 138
TYR A 175
GLY A  85
GLY A 136
 None
 1.09A 5i6xA-2duaA:
undetectable		 5i6xA-2duaA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 ALA A 559
ILE A 498
PHE A 467
GLY A 500
VAL A 471
 None
 1.16A 5i6xA-2e8yA:
undetectable		 5i6xA-2e8yA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nv4 UPF0066 PROTEIN
AF_0241

(Archaeoglobus
fulgidus) 		PF01980
(UPF0066) 		5 ASP A 120
ALA A  33
ILE A  32
GLY A  41
GLY A   7
 None
 1.04A 5i6xA-2nv4A:
undetectable		 5i6xA-2nv4A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		5 ALA A  93
ILE A 103
GLY A 129
PHE A 126
SER A 145
 None
 1.02A 5i6xA-2oajA:
undetectable		 5i6xA-2oajA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqp LARGE CAPSID PROTEIN

(Providence
virus) 		PF03566
(Peptidase_A21) 		5 ILE A 504
GLY A 497
PHE A 495
GLY A 437
VAL A 145
 None
 1.17A 5i6xA-2qqpA:
undetectable		 5i6xA-2qqpA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjt BETA-KETOACYL-ACP
SYNTHASE II

(Streptococcus
pneumoniae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ALA A 374
ILE A 372
TYR A 371
GLY A 304
GLY A 316
 None
 1.20A 5i6xA-2rjtA:
undetectable		 5i6xA-2rjtA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmp MUCOROPEPSIN

(Rhizomucor
miehei) 		PF00026
(Asp) 		5 ASP A  38
ILE A  80
GLY A 131
GLY A  85
VAL A 111
 None
 1.25A 5i6xA-2rmpA:
undetectable		 5i6xA-2rmpA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aay PUTATIVE THIOSULFATE
SULFURTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00581
(Rhodanese) 		5 ILE A  74
GLY A 102
PHE A  98
SER A  66
VAL A 106
 None
 1.11A 5i6xA-3aayA:
undetectable		 5i6xA-3aayA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brk GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE

(Agrobacterium
tumefaciens) 		PF00483
(NTP_transferase) 		5 ASP X  48
ALA X  15
ILE X  62
GLY X 134
SER X  52
 None
 1.26A 5i6xA-3brkX:
undetectable		 5i6xA-3brkX:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czp PUTATIVE
POLYPHOSPHATE KINASE
2

(Pseudomonas
aeruginosa) 		PF03976
(PPK2) 		5 ALA A 301
ILE A 360
TYR A 327
GLY A 312
PHE A 303
 None
None
None
GOL  A 610 ( 4.5A)
None
 1.16A 5i6xA-3czpA:
0.4		 5i6xA-3czpA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dms ISOCITRATE
DEHYDROGENASE [NADP]

(Burkholderia
pseudomallei) 		PF00180
(Iso_dh) 		5 TYR A 135
PHE A 395
SER A 141
GLY A 321
VAL A 391
 None
 1.26A 5i6xA-3dmsA:
undetectable		 5i6xA-3dmsA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efb PROBABLE SOR-OPERON
REGULATOR

(Shigella
flexneri) 		PF04198
(Sugar-bind) 		5 ASP A  27
ALA A 158
ILE A 157
TYR A 227
GLY A  49
 None
 1.24A 5i6xA-3efbA:
undetectable		 5i6xA-3efbA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG

(Homo sapiens) 		PF09445
(Methyltransf_15) 		5 ALA A 732
ILE A 706
GLY A 712
GLY A 736
VAL A 715
 None
 1.12A 5i6xA-3egiA:
undetectable		 5i6xA-3egiA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 ASP B 425
ALA B 365
GLY B 407
PHE B 401
SER B 423
 None
 0.81A 5i6xA-3jcmB:
undetectable		 5i6xA-3jcmB:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd6 CARBOHYDRATE KINASE,
PFKB FAMILY

(Chlorobaculum
tepidum) 		PF00294
(PfkB) 		5 ALA A 240
ILE A 171
GLY A 209
GLY A 236
VAL A 262
 None
None
None
GOL  A 501 ( 3.2A)
None
 1.14A 5i6xA-3kd6A:
undetectable		 5i6xA-3kd6A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdj PROTEIN PHOSPHATASE
2C 56

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		5 ASP B 165
ALA B 197
ILE B 200
PHE B 151
VAL B 248
 None
 1.15A 5i6xA-3kdjB:
undetectable		 5i6xA-3kdjB:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lt3 POSSIBLE
MEMBRANE-ASSOCIATED
SERINE PROTEASE

(Mycobacterium
tuberculosis) 		PF13365
(Trypsin_2) 		5 ALA A 307
ILE A 334
TYR A 332
GLY A 345
VAL A 338
 None
 1.24A 5i6xA-3lt3A:
undetectable		 5i6xA-3lt3A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mg6 PROTEASOME COMPONENT
C11

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 ALA J  56
ILE J  59
GLY J 102
SER J  38
VAL J  99
 None
 1.20A 5i6xA-3mg6J:
undetectable		 5i6xA-3mg6J:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2q SEX PHEROMONE
STAPH-CAM373

(Bacillus cereus) 		PF07537
(CamS) 		5 ALA A 298
ILE A 252
PHE A 248
GLY A 301
VAL A 263
 None
 1.18A 5i6xA-3n2qA:
undetectable		 5i6xA-3n2qA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngm EXTRACELLULAR LIPASE

(Fusarium
graminearum) 		PF01764
(Lipase_3) 		5 ALA A 122
ILE A 118
GLY A 146
PHE A  79
SER A  26
 None
 1.08A 5i6xA-3ngmA:
undetectable		 5i6xA-3ngmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqh GLYCOSYL HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		5 ILE A 428
GLY A 382
PHE A 403
SER A 355
VAL A 401
 None
 1.25A 5i6xA-3nqhA:
undetectable		 5i6xA-3nqhA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I

(Rhodobacter
sphaeroides) 		PF00115
(COX1) 		5 ALA A 236
ILE A 239
PHE A 116
SER A 200
GLY A 204
 None
 1.03A 5i6xA-3omnA:
0.4		 5i6xA-3omnA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt7 HEMOGLOBIN II

(Phacoides
pectinatus) 		PF00042
(Globin) 		5 ASP A 120
ALA A 110
ILE A 113
GLY A  28
PHE A  29
 None
HEM  A 500 ( 3.8A)
None
None
None
 1.12A 5i6xA-3pt7A:
undetectable		 5i6xA-3pt7A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2k OXIDOREDUCTASE

(Bordetella
pertussis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 TYR A 336
ALA A 225
GLY A 183
PHE A 185
VAL A 239
 None
 1.19A 5i6xA-3q2kA:
undetectable		 5i6xA-3q2kA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		5 ASP B1004
ILE B1069
PHE B 916
SER B1007
GLY B1009
 None
 1.18A 5i6xA-3qd2B:
undetectable		 5i6xA-3qd2B:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8k UNCHARACTERIZED
PROTEIN

(Leptotrichia
buccalis) 		no annotation 5 TYR A 122
ILE A 136
TYR A 133
PHE A  80
VAL A 115
 None
 1.06A 5i6xA-3t8kA:
undetectable		 5i6xA-3t8kA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcm ALANINE
AMINOTRANSFERASE 2

(Hordeum vulgare) 		PF00155
(Aminotran_1_2) 		5 ALA A 375
ILE A 455
TYR A 398
GLY A 300
GLY A 395
 None
None
DCS  A 501 (-4.4A)
None
None
 1.13A 5i6xA-3tcmA:
undetectable		 5i6xA-3tcmA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		5 ILE A 183
GLY A 232
PHE A 235
GLY A 228
VAL A 192
 None
 1.23A 5i6xA-3ua4A:
undetectable		 5i6xA-3ua4A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwp (S)-HYDROXYNITRILE
LYASE

(Baliospermum
montanum) 		PF00561
(Abhydrolase_1) 		5 ALA A  35
ILE A  36
GLY A  82
SER A  41
GLY A  15
 None
 1.09A 5i6xA-3wwpA:
undetectable		 5i6xA-3wwpA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zj0 ACETYLTRANSFERASE

(Oceanicola
granulosus) 		PF00583
(Acetyltransf_1) 		5 ASP A  38
ALA A 115
ILE A 116
GLY A  43
SER A 109
 None
 1.07A 5i6xA-3zj0A:
undetectable		 5i6xA-3zj0A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zkj ANKYRIN REPEAT AND
SOCS BOX PROTEIN 9

(Homo sapiens) 		PF07525
(SOCS_box)
PF12796
(Ank_2) 		5 ASP A 161
ALA A 155
ILE A 154
GLY A 271
GLY A 157
 None
 1.15A 5i6xA-3zkjA:
undetectable		 5i6xA-3zkjA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b96 CELLULOSE BINDING
DOMAIN-CONTAINING
PROTEIN

([Clostridium]
clariflavum) 		PF00942
(CBM_3) 		6 TYR A  60
ILE A  27
GLY A  93
PHE A  90
SER A  61
VAL A  40
 None
 1.42A 5i6xA-4b96A:
undetectable		 5i6xA-4b96A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 ASP A 839
ALA A 799
ILE A 798
PHE A 801
VAL A 712
 None
AGS  A1985 ( 4.5A)
None
None
None
 1.25A 5i6xA-4crsA:
undetectable		 5i6xA-4crsA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d47 LEVANSUCRASE

(Erwinia
amylovora) 		PF02435
(Glyco_hydro_68) 		5 ALA A 260
ILE A 272
GLY A 221
PHE A 219
SER A 184
 None
 1.17A 5i6xA-4d47A:
undetectable		 5i6xA-4d47A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eb5 PROBABLE CYSTEINE
DESULFURASE 2

(Archaeoglobus
fulgidus) 		PF00266
(Aminotran_5) 		5 ALA A 208
ILE A 195
GLY A 202
PHE A 243
GLY A  68
 None
None
None
None
PLP  A 401 ( 4.6A)
 1.22A 5i6xA-4eb5A:
undetectable		 5i6xA-4eb5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exl PHOSPHATE-BINDING
PROTEIN PSTS 1

(Streptococcus
pneumoniae) 		PF12849
(PBP_like_2) 		5 ASP A  86
ALA A  35
GLY A  66
SER A  85
GLY A  83
 None
 1.25A 5i6xA-4exlA:
undetectable		 5i6xA-4exlA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f2n SUPEROXIDE DISMUTASE

(Leishmania
major) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 ALA A 103
ILE A  86
GLY A  91
PHE A  99
GLY A 177
 None
 1.21A 5i6xA-4f2nA:
2.0		 5i6xA-4f2nA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ASP A1005
ILE A1070
PHE A 917
SER A1008
GLY A1010
 None
 1.22A 5i6xA-4g34A:
undetectable		 5i6xA-4g34A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gox POLYKETIDE SYNTHASE

(Synechococcus
sp. PCC 7002) 		PF13469
(Sulfotransfer_3) 		5 ASP A 132
ILE A 117
TYR A 118
GLY A  82
VAL A 104
 None
 1.23A 5i6xA-4goxA:
undetectable		 5i6xA-4goxA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htf S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		5 ALA B  86
ILE B  60
GLY B  66
GLY B  90
VAL B  69
 None
 1.12A 5i6xA-4htfB:
undetectable		 5i6xA-4htfB:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9j IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF

(Thermotoga
maritima) 		PF00977
(His_biosynth) 		5 TYR A 207
ALA A   9
ILE A   6
PHE A 235
GLY A 228
 None
 1.09A 5i6xA-4j9jA:
undetectable		 5i6xA-4j9jA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxk OXIDOREDUCTASE

(Rhodococcus
opacus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 240
ILE A 235
GLY A 150
GLY A 238
VAL A 152
 None
 1.26A 5i6xA-4jxkA:
undetectable		 5i6xA-4jxkA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmc NUCLEOPROTEIN

(Betacoronavirus
1) 		PF00937
(Corona_nucleoca) 		5 TYR A 100
ASP A 136
ALA A 159
GLY A 131
GLY A  99
 None
 1.01A 5i6xA-4lmcA:
undetectable		 5i6xA-4lmcA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mi2 PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		5 ALA A 131
ILE A 111
GLY A 138
PHE A 137
GLY A 113
 None
 1.15A 5i6xA-4mi2A:
2.4		 5i6xA-4mi2A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		5 ASP A 112
TYR A 134
PHE A 154
GLY A 137
VAL A 167
 None
None
2R8  A 301 (-3.7A)
GOL  A 305 ( 3.2A)
None
 1.14A 5i6xA-4nwkA:
undetectable		 5i6xA-4nwkA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwv CAPSID PROTEIN

(Orsay virus) 		PF11729
(Capsid-VNN) 		5 ILE A  76
GLY A 118
PHE A 101
SER A  73
VAL A 156
 None
 1.05A 5i6xA-4nwvA:
undetectable		 5i6xA-4nwvA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nww CAPSID PROTEIN

(Orsay virus) 		PF11729
(Capsid-VNN) 		5 ILE A  76
GLY A 118
PHE A 101
SER A  73
VAL A 156
 None
 1.09A 5i6xA-4nwwA:
undetectable		 5i6xA-4nwwA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00171
(Aldedh) 		5 ASP A 233
ALA A 377
ILE A 270
GLY A 390
SER A 384
 None
 1.21A 5i6xA-4ohtA:
undetectable		 5i6xA-4ohtA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4olq ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Hyphomonas
neptunium) 		PF00378
(ECH_1) 		5 ALA A 125
ILE A 105
GLY A 132
PHE A 131
GLY A 107
 None
 1.20A 5i6xA-4olqA:
undetectable		 5i6xA-4olqA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8i PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Bacillus
subtilis) 		no annotation 5 ASP A 104
ALA A 119
ILE A 122
GLY A  77
PHE A 114
 None
 1.19A 5i6xA-4p8iA:
undetectable		 5i6xA-4p8iA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkx LYS-GINGIPAIN W83

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		5 ILE L 556
GLY L 506
SER L 520
GLY L 560
VAL L 587
 None
 1.12A 5i6xA-4tkxL:
undetectable		 5i6xA-4tkxL:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wec SHORT CHAIN
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 ALA A 158
TYR A 156
GLY A 148
SER A 142
GLY A 161
 None
NAD  A 301 (-4.3A)
None
NAD  A 301 (-3.6A)
None
 1.18A 5i6xA-4wecA:
undetectable		 5i6xA-4wecA:
18.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		6 ASP A  46
ALA A 117
TYR A 124
GLY A 322
SER A 421
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 ( 3.7A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.57A 5i6xA-4xnuA:
55.0		 5i6xA-4xnuA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		5 ASP A  46
TYR A 124
GLY A 322
SER A 421
GLY A 424
 41U  A 605 ( 3.3A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
None
 0.77A 5i6xA-4xnuA:
55.0		 5i6xA-4xnuA:
53.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfm BETA-LACTAMASE

(Mycobacteroides
abscessus) 		PF13354
(Beta-lactamase2) 		5 TYR A  98
ALA A 126
ILE A 109
GLY A 117
GLY A 135
 None
 1.25A 5i6xA-4yfmA:
undetectable		 5i6xA-4yfmA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn7 MALTODEXTRIN
GLUCOSIDASE

(Escherichia
coli) 		PF00128
(Alpha-amylase) 		5 ASP A 180
GLY A 224
PHE A 223
SER A 136
GLY A 177
 None
 1.15A 5i6xA-5bn7A:
undetectable		 5i6xA-5bn7A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5drn FAB HPU24 HEAVY
CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ALA A  93
ILE A  35
GLY A  52
GLY A  95
VAL A  76
 None
 1.13A 5i6xA-5drnA:
undetectable		 5i6xA-5drnA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0a TRANSAMINASE

(Bacillus
megaterium) 		PF00202
(Aminotran_3) 		5 ALA A  98
ILE A 101
GLY A 308
PHE A 117
VAL A 341
 None
 0.68A 5i6xA-5g0aA:
undetectable		 5i6xA-5g0aA:
20.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER

(Homo sapiens) 		PF00209
(SNF) 		10 TYR A  95
ASP A  98
ALA A 169
ILE A 172
TYR A 176
GLY A 338
PHE A 341
SER A 438
GLY A 442
VAL A 501
 None
 0.20A 5i6xA-5i6zA:
65.9		 5i6xA-5i6zA:
99.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwd DNA POLYMERASE
PROCESSIVITY FACTOR

(Human
betaherpesvirus
5) 		PF03325
(Herpes_PAP) 		5 ASP A 147
ALA A 190
ILE A 191
GLY A 213
SER A 210
 None
 1.24A 5i6xA-5iwdA:
undetectable		 5i6xA-5iwdA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc9 LAMININ SUBUNIT
ALPHA-1

(Mus musculus) 		PF00054
(Laminin_G_1)
PF06009
(Laminin_II) 		5 ILE A2632
GLY A2652
PHE A2499
GLY A2634
VAL A2497
 None
 1.18A 5i6xA-5mc9A:
undetectable		 5i6xA-5mc9A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx PHOTOSYSTEM II
PROTEIN D1

(Arabidopsis
thaliana) 		PF00124
(Photo_RC) 		5 ILE A  77
GLY A  69
PHE A  52
SER A 177
GLY A 175
 None
 1.21A 5i6xA-5mdxA:
2.2		 5i6xA-5mdxA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN

(Azotobacter
vinelandii) 		no annotation 5 TYR E 281
GLY E 451
SER E 441
GLY E 443
VAL E 348
 None
 1.09A 5i6xA-5n6yE:
undetectable		 5i6xA-5n6yE:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olt -

(-) 		no annotation 5 ALA A 496
ILE A 497
TYR A 494
PHE A 268
VAL A 472
 None
 1.24A 5i6xA-5oltA:
undetectable		 5i6xA-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sv5 MICROBIAL
COLLAGENASE

(Bacillus
anthracis) 		PF04151
(PPC) 		5 ILE A 899
GLY A 871
PHE A 891
SER A 963
VAL A 893
 None
 1.23A 5i6xA-5sv5A:
undetectable		 5i6xA-5sv5A:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1q N-ACETYLMURAMOYL-L-A
LANINE AMIDASE
DOMAIN-CONTAINING
PROTEIN
SAOUHSC_02979

(Staphylococcus
aureus) 		PF01832
(Glucosaminidase)
PF05257
(CHAP) 		5 ALA A 557
ILE A 616
TYR A 547
SER A 527
VAL A 575
 None
 1.21A 5i6xA-5t1qA:
undetectable		 5i6xA-5t1qA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wsl KERATINASE

(Meiothermus
taiwanensis) 		no annotation 5 ALA A  77
GLY A  51
PHE A  49
GLY A  81
VAL A  44
 None
 1.23A 5i6xA-5wslA:
undetectable		 5i6xA-5wslA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0m -

(-) 		no annotation 5 ASP A 158
ALA A 181
GLY A 117
GLY A 108
VAL A  74
 None
 1.08A 5i6xA-5y0mA:
undetectable		 5i6xA-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao7 ACETYLTRANSFERASE

(Elizabethkingia
anophelis) 		PF00583
(Acetyltransf_1) 		5 ASP A  86
ALA A  69
ILE A  68
TYR A  53
GLY A  51
 None
ACO  A 201 (-3.8A)
ACO  A 201 (-4.5A)
None
None
 1.25A 5i6xA-6ao7A:
undetectable		 5i6xA-6ao7A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0e ISOCITRATE
DEHYDROGENASE

(Legionella
pneumophila) 		no annotation 5 TYR A 139
GLY A 402
PHE A 399
GLY A 324
VAL A 395
 None
 1.24A 5i6xA-6c0eA:
undetectable		 5i6xA-6c0eA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epd PROTEASOME SUBUNIT
BETA TYPE-4

(Rattus
norvegicus) 		no annotation 5 ASP 7 170
ALA 7  67
ILE 7  66
TYR 7 168
GLY 7  99
 None
 1.15A 5i6xA-6epd7:
undetectable		 5i6xA-6epd7:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fay ODZ3 PROTEIN

(Mus musculus) 		no annotation 5 ILE A1313
TYR A1314
GLY A1328
GLY A1311
VAL A1273
 None
 1.18A 5i6xA-6fayA:
undetectable		 5i6xA-6fayA:
12.33