SIMILAR PATTERNS OF AMINO ACIDS FOR 5I1P_G_DVAG9_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		3 ALA A 258
ASN A 261
LEU A 262
 None
 0.47A 5i1pD-1ao0A:
0.0		 5i1pD-1ao0A:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aq0 1,3-1,4-BETA-GLUCANA
SE

(Hordeum vulgare) 		PF00332
(Glyco_hydro_17) 		3 ALA A  98
ASN A 101
LEU A 102
 None
 0.49A 5i1pD-1aq0A:
0.0		 5i1pD-1aq0A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bik BIKUNIN

(Homo sapiens) 		PF00014
(Kunitz_BPTI) 		3 ALA A  80
ASN A  83
LEU A  84
 None
 0.35A 5i1pD-1bikA:
undetectable		 5i1pD-1bikA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		3 ALA A 327
ASN A 330
LEU A 331
 None
 0.33A 5i1pD-1biyA:
0.0		 5i1pD-1biyA:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by1 PROTEIN (PIX)

(Homo sapiens) 		PF00621
(RhoGEF) 		3 ALA A 182
ASN A 185
LEU A 186
 None
 0.30A 5i1pD-1by1A:
0.0		 5i1pD-1by1A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE

(Lactobacillus
casei) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 ALA A 218
ASN A 221
LEU A 222
 None
 0.49A 5i1pD-1dxyA:
0.0		 5i1pD-1dxyA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f26 NITRIC OXIDE
REDUCTASE

(Fusarium
oxysporum) 		PF00067
(p450) 		3 ALA A 109
ASN A 112
LEU A 113
 None
 0.46A 5i1pD-1f26A:
0.0		 5i1pD-1f26A:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8w NADH PEROXIDASE

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 ALA A 309
ASN A 312
LEU A 313
 None
 0.50A 5i1pD-1f8wA:
0.0		 5i1pD-1f8wA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fep FERRIC ENTEROBACTIN
RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ALA A  19
ASN A  22
LEU A  23
 None
 0.39A 5i1pD-1fepA:
0.0		 5i1pD-1fepA:
4.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4g ENTEROTOXIN TYPE A

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		3 ALA A  22
ASN A  25
LEU A  26
 None
 0.43A 5i1pD-1i4gA:
undetectable		 5i1pD-1i4gA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid) 		3 ALA A 273
ASN A 274
LEU A 275
 None
 0.49A 5i1pD-1i5pA:
undetectable		 5i1pD-1i5pA:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy9 SPERMIDINE SYNTHASE

(Bacillus
subtilis) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 ALA A 164
ASN A 166
LEU A 167
 None
 0.47A 5i1pD-1iy9A:
undetectable		 5i1pD-1iy9A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF01702
(TGT)
PF14809
(TGT_C1)
PF14810
(TGT_C2) 		3 ALA A 305
ASN A 308
LEU A 309
 None
 0.49A 5i1pD-1j2bA:
undetectable		 5i1pD-1j2bA:
4.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j9m DD-TRANSPEPTIDASE

(Streptomyces
sp. K15) 		PF00768
(Peptidase_S11) 		3 ALA A 128
ASN A 131
LEU A 132
 None
 0.47A 5i1pD-1j9mA:
undetectable		 5i1pD-1j9mA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ALA A 656
ASN A 657
LEU A 658
 None
 0.47A 5i1pD-1kcwA:
undetectable		 5i1pD-1kcwA:
3.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lk0 ARSENATE REDUCTASE

(Staphylococcus
aureus) 		PF01451
(LMWPc) 		3 ALA A  85
ASN A  88
LEU A  89
 None
 0.33A 5i1pD-1lk0A:
undetectable		 5i1pD-1lk0A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 ALA A 327
ASN A 330
LEU A 331
 None
 0.29A 5i1pD-1n76A:
undetectable		 5i1pD-1n76A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2f PROTEIN
(RIBONUCLEOTIDE
REDUCTASE R2)

(Salmonella
enterica) 		PF00268
(Ribonuc_red_sm) 		3 ALA A 261
ASN A 264
LEU A 265
 None
 0.50A 5i1pD-1r2fA:
undetectable		 5i1pD-1r2fA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si8 CATALASE

(Enterococcus
faecalis) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 ALA A 422
ASN A 425
LEU A 426
 None
 0.49A 5i1pD-1si8A:
undetectable		 5i1pD-1si8A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sny SNIFFER CG10964-PA

(Drosophila
melanogaster) 		PF00106
(adh_short) 		3 ALA A  21
ASN A  24
LEU A  25
 None
 0.32A 5i1pD-1snyA:
undetectable		 5i1pD-1snyA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svf PROTEIN (FUSION
GLYCOPROTEIN)

(Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly) 		3 ALA A 136
ASN A 139
LEU A 140
 None
 0.49A 5i1pD-1svfA:
undetectable		 5i1pD-1svfA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ucp APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD

(Homo sapiens) 		PF02758
(PYRIN) 		3 ALA A  11
ASN A  14
LEU A  15
 None
 0.46A 5i1pD-1ucpA:
undetectable		 5i1pD-1ucpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us2 ENDO-BETA-1,4-XYLANA
SE

(Cellvibrio
japonicus) 		PF00331
(Glyco_hydro_10)
PF03426
(CBM_15) 		3 ALA A 164
ASN A 165
LEU A 166
 None
 0.45A 5i1pD-1us2A:
undetectable		 5i1pD-1us2A:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		3 ALA A 470
ASN A 473
LEU A 474
 None
 0.43A 5i1pD-1v4gA:
undetectable		 5i1pD-1v4gA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl4 PMBA-RELATED PROTEIN

(Thermotoga
maritima) 		PF01523
(PmbA_TldD) 		3 ALA A  79
ASN A  82
LEU A  83
 None
 0.34A 5i1pD-1vl4A:
undetectable		 5i1pD-1vl4A:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqr HYPOTHETICAL PROTEIN
CJ0248

(Campylobacter
jejuni) 		PF08668
(HDOD) 		3 ALA A 277
ASN A 280
LEU A 281
 None
 0.38A 5i1pD-1vqrA:
undetectable		 5i1pD-1vqrA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		3 ALA A 202
ASN A 205
LEU A 206
 None
 0.48A 5i1pD-1wpwA:
undetectable		 5i1pD-1wpwA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wr6 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3

(Homo sapiens) 		PF03127
(GAT) 		3 ALA A 282
ASN A 285
LEU A 286
 None
 0.49A 5i1pD-1wr6A:
undetectable		 5i1pD-1wr6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xsx SSO10A

(Sulfolobus
solfataricus) 		PF14947
(HTH_45) 		3 ALA A  30
ASN A  31
LEU A  32
 None
 0.48A 5i1pD-1xsxA:
undetectable		 5i1pD-1xsxA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb2 HYPOTHETICAL PROTEIN
TA0852

(Thermoplasma
acidophilum) 		PF08704
(GCD14) 		3 ALA A 131
ASN A 134
LEU A 135
 None
 0.49A 5i1pD-1yb2A:
undetectable		 5i1pD-1yb2A:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yc9 MULTIDRUG RESISTANCE
PROTEIN

(Vibrio cholerae) 		PF02321
(OEP) 		3 ALA A 456
ASN A 459
LEU A 460
 None
 0.50A 5i1pD-1yc9A:
undetectable		 5i1pD-1yc9A:
6.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw5 PEPTIDYL PROLYL
CIS/TRANS ISOMERASE

(Candida
albicans) 		PF00397
(WW)
PF00639
(Rotamase) 		3 ALA A 151
ASN A 154
LEU A 155
 None
 0.49A 5i1pD-1yw5A:
undetectable		 5i1pD-1yw5A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zp6 HYPOTHETICAL PROTEIN
ATU3015

(Agrobacterium
fabrum) 		PF13238
(AAA_18) 		3 ALA A  28
ASN A  31
LEU A  32
 None
 0.20A 5i1pD-1zp6A:
undetectable		 5i1pD-1zp6A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as0 HYPOTHETICAL PROTEIN
PH1915

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF10672
(Methyltrans_SAM) 		3 ALA A 320
ASN A 323
LEU A 324
 None
 0.50A 5i1pD-2as0A:
undetectable		 5i1pD-2as0A:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP3 CORE
PROTEIN)

(Bluetongue
virus) 		PF01700
(Orbi_VP3) 		3 ALA A 650
ASN A 653
LEU A 654
 None
 0.26A 5i1pD-2btvA:
undetectable		 5i1pD-2btvA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfz SDS HYDROLASE SDSA1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		3 ALA A  99
ASN A 102
LEU A 103
 None
 0.47A 5i1pD-2cfzA:
undetectable		 5i1pD-2cfzA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw3 IRON SUPEROXIDE
DISMUTASE

(Perkinsus
marinus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 ALA A 199
ASN A 202
LEU A 203
 None
 0.27A 5i1pD-2cw3A:
undetectable		 5i1pD-2cw3A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ds2 SWEET PROTEIN
MABINLIN-2 CHAIN B

(Capparis
masaikai) 		PF00234
(Tryp_alpha_amyl) 		3 ALA B  51
ASN B  54
LEU B  55
 None
 0.32A 5i1pD-2ds2B:
undetectable		 5i1pD-2ds2B:
29.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebm RWD
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF05773
(RWD) 		3 ALA A  98
ASN A 101
LEU A 102
 None
 0.40A 5i1pD-2ebmA:
undetectable		 5i1pD-2ebmA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE

(Azoarcus) 		PF13561
(adh_short_C2) 		3 ALA A  48
ASN A  51
LEU A  52
 None
 0.45A 5i1pD-2ewmA:
undetectable		 5i1pD-2ewmA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ALA A   6
ASN A   7
LEU A   8
 None
 0.48A 5i1pD-2hzhA:
undetectable		 5i1pD-2hzhA:
4.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqi HYPOTHETICAL PROTEIN
XCC0632

(Xanthomonas
campestris) 		PF03886
(ABC_trans_aux) 		3 ALA A 150
ASN A 149
LEU A 148
 None
 0.43A 5i1pD-2iqiA:
undetectable		 5i1pD-2iqiA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kn6 APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD

(Homo sapiens) 		PF00619
(CARD)
PF02758
(PYRIN) 		3 ALA A  11
ASN A  14
LEU A  15
 None
 0.37A 5i1pD-2kn6A:
undetectable		 5i1pD-2kn6A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3y INTERLEUKIN-6

(Mus musculus) 		PF00489
(IL6) 		3 ALA A  63
ASN A  66
LEU A  67
 None
 0.47A 5i1pD-2l3yA:
undetectable		 5i1pD-2l3yA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n4k ENTEROCIN-HF

(Enterococcus
faecium) 		PF01721
(Bacteriocin_II) 		3 ALA A  29
ASN A  32
LEU A  33
 None
 0.44A 5i1pD-2n4kA:
undetectable		 5i1pD-2n4kA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00106
(adh_short) 		3 ALA A  68
ASN A  71
LEU A  72
 None
 0.25A 5i1pD-2nwqA:
undetectable		 5i1pD-2nwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5a BH1328 PROTEIN

(Bacillus
halodurans) 		PF02410
(RsfS) 		3 ALA A  96
ASN A  99
LEU A 100
 None
 0.43A 5i1pD-2o5aA:
undetectable		 5i1pD-2o5aA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfi CHLORIDE CHANNEL
PROTEIN CLC-KA

(Homo sapiens) 		PF00571
(CBS) 		3 ALA A 676
ASN A 679
LEU A 680
 CL  A 504 ( 4.2A)
CL  A 504 ( 4.8A)
None
 0.18A 5i1pD-2pfiA:
undetectable		 5i1pD-2pfiA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfk 6-PHOSPHOFRUCTOKINAS
E ISOZYME I

(Escherichia
coli) 		PF00365
(PFK) 		3 ALA A  85
ASN A  88
LEU A  89
 None
 0.48A 5i1pD-2pfkA:
undetectable		 5i1pD-2pfkA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo sapiens) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		3 ALA A 286
ASN A 289
LEU A 290
 None
 0.46A 5i1pD-2pkgA:
undetectable		 5i1pD-2pkgA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qb6 EXOPOLYPHOSPHATASE

(Saccharomyces
cerevisiae) 		PF01368
(DHH)
PF02833
(DHHA2) 		3 ALA A 391
ASN A 394
LEU A 395
 None
 0.21A 5i1pD-2qb6A:
undetectable		 5i1pD-2qb6A:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qna IMPORTIN SUBUNIT
BETA-1

(Homo sapiens) 		PF13513
(HEAT_EZ) 		3 ALA A 237
ASN A 240
LEU A 241
 None
 0.45A 5i1pD-2qnaA:
undetectable		 5i1pD-2qnaA:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ALA A 482
ASN A 485
LEU A 486
 None
 0.18A 5i1pD-2qt6A:
undetectable		 5i1pD-2qt6A:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vak SIGMA A

(Avian
orthoreovirus) 		PF03084
(Sigma_1_2) 		3 ALA A 295
ASN A 298
LEU A 299
 None
 0.47A 5i1pD-2vakA:
undetectable		 5i1pD-2vakA:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf1 CAPSID PROTEIN

(Rabbit
picobirnavirus) 		no annotation 3 ALA A 227
ASN A 230
LEU A 231
 None
 0.49A 5i1pD-2vf1A:
undetectable		 5i1pD-2vf1A:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf8 EXCINUCLEASE ABC
SUBUNIT A

(Deinococcus
radiodurans) 		PF00005
(ABC_tran) 		3 ALA A 423
ASN A 426
LEU A 427
 None
 0.46A 5i1pD-2vf8A:
undetectable		 5i1pD-2vf8A:
3.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrs SIGMA-C CAPSID
PROTEIN

(Avian
orthoreovirus) 		PF04582
(Reo_sigmaC) 		3 ALA A 127
ASN A 130
LEU A 131
 None
 0.47A 5i1pD-2vrsA:
undetectable		 5i1pD-2vrsA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5f ASPARTATE_TYROSINE_P
HENYLALANINE
PYRIDOXAL-5'
PHOSPHATE-DEPENDENT
AMINOTRANSFERASE

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		3 ALA A 158
ASN A 159
LEU A 160
 None
 0.50A 5i1pD-2x5fA:
undetectable		 5i1pD-2x5fA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5f ASPARTATE_TYROSINE_P
HENYLALANINE
PYRIDOXAL-5'
PHOSPHATE-DEPENDENT
AMINOTRANSFERASE

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		3 ALA A 250
ASN A 253
LEU A 254
 None
 0.17A 5i1pD-2x5fA:
undetectable		 5i1pD-2x5fA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhe UNC18

(Monosiga
brevicollis) 		PF00995
(Sec1) 		3 ALA A 438
ASN A 441
LEU A 442
 None
 0.46A 5i1pD-2xheA:
undetectable		 5i1pD-2xheA:
4.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zws NEUTRAL CERAMIDASE

(Pseudomonas
aeruginosa) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		3 ALA A 109
ASN A 112
LEU A 113
 GOL  A 655 (-3.7A)
None
None
 0.43A 5i1pD-2zwsA:
undetectable		 5i1pD-2zwsA:
5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afe HYDROXYLASE,
PUTATIVE

(Mycobacterium
tuberculosis) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		3 ALA A  15
ASN A  18
LEU A  19
 None
 0.39A 5i1pD-3afeA:
undetectable		 5i1pD-3afeA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		3 ALA A  47
ASN A  50
LEU A  51
 None
 0.44A 5i1pD-3cghA:
undetectable		 5i1pD-3cghA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr3 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE, ADP-BINDING
SUBUNIT DHAL

(Lactococcus
lactis) 		PF02734
(Dak2) 		3 ALA A 140
ASN A 144
LEU A 145
 None
 0.44A 5i1pD-3cr3A:
undetectable		 5i1pD-3cr3A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr3 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
PHOSPHOTRANSFERASE
SUBUNIT DHAM

(Lactococcus
lactis) 		PF03610
(EIIA-man) 		3 ALA C  70
ASN C  73
LEU C  74
 None
 0.46A 5i1pD-3cr3C:
undetectable		 5i1pD-3cr3C:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d00 TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT E

(Syntrophus
aciditrophicus) 		PF02663
(FmdE) 		3 ALA A  39
ASN A  42
LEU A  43
 None
 0.36A 5i1pD-3d00A:
undetectable		 5i1pD-3d00A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db2 PUTATIVE
NADPH-DEPENDENT
OXIDOREDUCTASE

(Desulfitobacterium
hafniense) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 ALA A 249
ASN A 250
LEU A 251
 None
 0.45A 5i1pD-3db2A:
undetectable		 5i1pD-3db2A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 ALA A 558
ASN A 561
LEU A 562
 None
 0.46A 5i1pD-3dy5A:
undetectable		 5i1pD-3dy5A:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7h DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Vibrio cholerae) 		no annotation 3 ALA A  94
ASN A  97
LEU A  98
 None
 0.36A 5i1pD-3e7hA:
undetectable		 5i1pD-3e7hA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fc3 RESTRICTION
ENDONUCLEASE HPY99I

(Helicobacter
pylori) 		PF02945
(Endonuclease_7) 		3 ALA A 143
ASN A 144
LEU A 145
 None
 0.49A 5i1pD-3fc3A:
undetectable		 5i1pD-3fc3A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcd LYASE

(uncultured
bacterium) 		no annotation 3 ALA A  85
ASN A  88
LEU A  89
 None
 0.35A 5i1pD-3fcdA:
undetectable		 5i1pD-3fcdA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj1 PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Ruegeria
pomeroyi) 		PF01380
(SIS) 		3 ALA A 178
ASN A 181
LEU A 182
 None
 0.25A 5i1pD-3fj1A:
undetectable		 5i1pD-3fj1A:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcd RTX TOXIN RTXA

(Vibrio cholerae) 		PF11713
(Peptidase_C80) 		3 ALA A  47
ASN A  50
LEU A  51
 AZ0  A 213 (-3.8A)
AZ0  A 213 (-3.8A)
None
 0.48A 5i1pD-3gcdA:
undetectable		 5i1pD-3gcdA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6p ESAT-6 LIKE PROTEIN
ESXS

(Mycobacterium
tuberculosis) 		PF06013
(WXG100) 		3 ALA A  72
ASN A  75
LEU A  76
 None
 0.37A 5i1pD-3h6pA:
undetectable		 5i1pD-3h6pA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 ALA B   4
ASN B   7
LEU B   8
 None
 0.40A 5i1pD-3hhsB:
undetectable		 5i1pD-3hhsB:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsy GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		3 ALA A 289
ASN A 292
LEU A 293
 None
 0.47A 5i1pD-3hsyA:
undetectable		 5i1pD-3hsyA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hww 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Escherichia
coli) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		3 ALA A  82
ASN A  85
LEU A  86
 NA  A 564 (-3.2A)
None
None
 0.40A 5i1pD-3hwwA:
undetectable		 5i1pD-3hwwA:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k85 D-GLYCERO-D-MANNO-HE
PTOSE 1-PHOSPHATE
KINASE

(Bacteroides
thetaiotaomicron) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 ALA A 317
ASN A 320
LEU A 321
 None
 0.26A 5i1pD-3k85A:
undetectable		 5i1pD-3k85A:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd7 CTPR390

(unidentified) 		PF13414
(TPR_11)
PF13432
(TPR_16) 		3 ALA A  11
ASN A  14
LEU A  15
 None
 0.48A 5i1pD-3kd7A:
undetectable		 5i1pD-3kd7A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8m PROBABLE THIAMINE
PYROPHOSPHOKINASE

(Staphylococcus
saprophyticus) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		3 ALA A   3
ASN A   4
LEU A   5
 None
 0.47A 5i1pD-3l8mA:
undetectable		 5i1pD-3l8mA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll3 GLUCONATE KINASE

(Lactobacillus
acidophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ALA A 381
ASN A 384
LEU A 385
 None
 0.44A 5i1pD-3ll3A:
undetectable		 5i1pD-3ll3A:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE

(Idiomarina
loihiensis) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		3 ALA A 198
ASN A 201
LEU A 202
 None
 0.48A 5i1pD-3llxA:
undetectable		 5i1pD-3llxA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mve UPF0255 PROTEIN
VV1_0328

(Vibrio
vulnificus) 		PF06500
(DUF1100) 		3 ALA A  20
ASN A 144
LEU A 145
 None
None
EDO  A 419 ( 3.6A)
 0.47A 5i1pD-3mveA:
undetectable		 5i1pD-3mveA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzn GLUCARATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF13378
(MR_MLE_C) 		3 ALA A 183
ASN A 186
LEU A 187
 None
 0.37A 5i1pD-3mznA:
undetectable		 5i1pD-3mznA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nk4 ZONA PELLUCIDA 3

(Gallus gallus) 		PF00100
(Zona_pellucida) 		3 ALA A  97
ASN A  96
LEU A  95
 None
 0.48A 5i1pD-3nk4A:
undetectable		 5i1pD-3nk4A:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntv MW1564 PROTEIN

(Staphylococcus
aureus) 		PF01596
(Methyltransf_3) 		3 ALA A 111
ASN A 114
LEU A 115
 None
 0.50A 5i1pD-3ntvA:
undetectable		 5i1pD-3ntvA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozv FLAVOHEMOGLOBIN

(Cupriavidus
necator) 		no annotation 3 ALA B 380
ASN B 383
LEU B 384
 None
 0.49A 5i1pD-3ozvB:
undetectable		 5i1pD-3ozvB:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0s CAPSID PROTEIN VP

(Lepidopteran
iteradensovirus
1) 		PF01057
(Parvo_NS1) 		3 ALA A 336
ASN A 339
LEU A 340
 None
 0.49A 5i1pD-3p0sA:
undetectable		 5i1pD-3p0sA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF02645
(DegV) 		3 ALA A 241
ASN A 244
LEU A 245
 None
 0.42A 5i1pD-3pl5A:
undetectable		 5i1pD-3pl5A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qml NUCLEOTIDE EXCHANGE
FACTOR SIL1

(Saccharomyces
cerevisiae) 		PF16782
(SIL1) 		3 ALA C 228
ASN C 231
LEU C 232
 None
 0.50A 5i1pD-3qmlC:
undetectable		 5i1pD-3qmlC:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ro2 G-PROTEIN-SIGNALING
MODULATOR 2

(Mus musculus) 		PF13176
(TPR_7)
PF13424
(TPR_12) 		3 ALA A  97
ASN A 100
LEU A 101
 None
GOL  A   2 (-3.6A)
None
 0.46A 5i1pD-3ro2A:
undetectable		 5i1pD-3ro2A:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skp SEROTRANSFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 ALA A 658
ASN A 661
LEU A 662
 None
 0.46A 5i1pD-3skpA:
undetectable		 5i1pD-3skpA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE

(Helicobacter
pylori) 		PF01370
(Epimerase) 		3 ALA A 118
ASN A 121
LEU A 122
 None
 0.46A 5i1pD-3sxpA:
undetectable		 5i1pD-3sxpA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ALA A 483
ASN A 486
LEU A 487
 None
 0.16A 5i1pD-3t6wA:
undetectable		 5i1pD-3t6wA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr0 GUANYLATE KINASE

(Coxiella
burnetii) 		PF00625
(Guanylate_kin) 		3 ALA A 173
ASN A 176
LEU A 177
 None
 0.45A 5i1pD-3tr0A:
undetectable		 5i1pD-3tr0A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twd BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep) 		3 ALA A 318
ASN A 319
LEU A 320
 None
 0.45A 5i1pD-3twdA:
undetectable		 5i1pD-3twdA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1d UNCHARACTERIZED
PROTEIN

(Halomicrobium
mukohataei) 		PF12840
(HTH_20) 		3 ALA A 129
ASN A 132
LEU A 133
 None
 0.40A 5i1pD-3u1dA:
undetectable		 5i1pD-3u1dA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v6a APOPTOSIS INHIBITOR
5

(Homo sapiens) 		PF05918
(API5) 		3 ALA A 112
ASN A 115
LEU A 116
 None
 0.48A 5i1pD-3v6aA:
undetectable		 5i1pD-3v6aA:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w36 NAPH1

(Streptomyces
sp. CNQ525) 		no annotation 3 ALA A 306
ASN A 309
LEU A 310
 None
 0.37A 5i1pD-3w36A:
undetectable		 5i1pD-3w36A:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b18 IMPORTIN SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		3 ALA A 235
ASN A 238
LEU A 239
 None
 0.35A 5i1pD-4b18A:
undetectable		 5i1pD-4b18A:
7.81