SIMILAR PATTERNS OF AMINO ACIDS FOR 5I1P_F_DVAF9_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		3 ALA A 258
ASN A 261
LEU A 262
 None
 0.36A 5i1pA-1ao0A:
0.0		 5i1pA-1ao0A:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bik BIKUNIN

(Homo sapiens) 		PF00014
(Kunitz_BPTI) 		3 ALA A  80
ASN A  83
LEU A  84
 None
 0.33A 5i1pA-1bikA:
0.0		 5i1pA-1bikA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		3 ALA A 327
ASN A 330
LEU A 331
 None
 0.31A 5i1pA-1biyA:
0.0		 5i1pA-1biyA:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by1 PROTEIN (PIX)

(Homo sapiens) 		PF00621
(RhoGEF) 		3 ALA A 182
ASN A 185
LEU A 186
 None
 0.24A 5i1pA-1by1A:
0.0		 5i1pA-1by1A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f26 NITRIC OXIDE
REDUCTASE

(Fusarium
oxysporum) 		PF00067
(p450) 		3 ALA A 109
ASN A 112
LEU A 113
 None
 0.39A 5i1pA-1f26A:
0.0		 5i1pA-1f26A:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fep FERRIC ENTEROBACTIN
RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ALA A  19
ASN A  22
LEU A  23
 None
 0.34A 5i1pA-1fepA:
0.0		 5i1pA-1fepA:
4.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4g ENTEROTOXIN TYPE A

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		3 ALA A  22
ASN A  25
LEU A  26
 None
 0.32A 5i1pA-1i4gA:
0.0		 5i1pA-1i4gA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lk0 ARSENATE REDUCTASE

(Staphylococcus
aureus) 		PF01451
(LMWPc) 		3 ALA A  85
ASN A  88
LEU A  89
 None
 0.21A 5i1pA-1lk0A:
0.0		 5i1pA-1lk0A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 ALA A 327
ASN A 330
LEU A 331
 None
 0.34A 5i1pA-1n76A:
0.1		 5i1pA-1n76A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si8 CATALASE

(Enterococcus
faecalis) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 ALA A 422
ASN A 425
LEU A 426
 None
 0.39A 5i1pA-1si8A:
undetectable		 5i1pA-1si8A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ucp APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD

(Homo sapiens) 		PF02758
(PYRIN) 		3 ALA A  11
ASN A  14
LEU A  15
 None
 0.34A 5i1pA-1ucpA:
undetectable		 5i1pA-1ucpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		3 ALA A 470
ASN A 473
LEU A 474
 None
 0.34A 5i1pA-1v4gA:
undetectable		 5i1pA-1v4gA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqr HYPOTHETICAL PROTEIN
CJ0248

(Campylobacter
jejuni) 		PF08668
(HDOD) 		3 ALA A 277
ASN A 280
LEU A 281
 None
 0.36A 5i1pA-1vqrA:
undetectable		 5i1pA-1vqrA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw5 PEPTIDYL PROLYL
CIS/TRANS ISOMERASE

(Candida
albicans) 		PF00397
(WW)
PF00639
(Rotamase) 		3 ALA A 151
ASN A 154
LEU A 155
 None
 0.37A 5i1pA-1yw5A:
undetectable		 5i1pA-1yw5A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zp6 HYPOTHETICAL PROTEIN
ATU3015

(Agrobacterium
fabrum) 		PF13238
(AAA_18) 		3 ALA A  28
ASN A  31
LEU A  32
 None
 0.32A 5i1pA-1zp6A:
undetectable		 5i1pA-1zp6A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as0 HYPOTHETICAL PROTEIN
PH1915

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF10672
(Methyltrans_SAM) 		3 ALA A 320
ASN A 323
LEU A 324
 None
 0.39A 5i1pA-2as0A:
undetectable		 5i1pA-2as0A:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP3 CORE
PROTEIN)

(Bluetongue
virus) 		PF01700
(Orbi_VP3) 		3 ALA A 650
ASN A 653
LEU A 654
 None
 0.34A 5i1pA-2btvA:
undetectable		 5i1pA-2btvA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfz SDS HYDROLASE SDSA1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		3 ALA A  99
ASN A 102
LEU A 103
 None
 0.39A 5i1pA-2cfzA:
undetectable		 5i1pA-2cfzA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw3 IRON SUPEROXIDE
DISMUTASE

(Perkinsus
marinus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 ALA A 199
ASN A 202
LEU A 203
 None
 0.27A 5i1pA-2cw3A:
undetectable		 5i1pA-2cw3A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ds2 SWEET PROTEIN
MABINLIN-2 CHAIN B

(Capparis
masaikai) 		PF00234
(Tryp_alpha_amyl) 		3 ALA B  51
ASN B  54
LEU B  55
 None
 0.26A 5i1pA-2ds2B:
undetectable		 5i1pA-2ds2B:
29.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE

(Azoarcus) 		PF13561
(adh_short_C2) 		3 ALA A  48
ASN A  51
LEU A  52
 None
 0.37A 5i1pA-2ewmA:
undetectable		 5i1pA-2ewmA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgc ACETOLACTATE
SYNTHASE, SMALL
SUBUNIT

(Thermotoga
maritima) 		PF01842
(ACT)
PF10369
(ALS_ss_C) 		3 ALA A 161
ASN A 164
LEU A 165
 None
 0.39A 5i1pA-2fgcA:
undetectable		 5i1pA-2fgcA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kn6 APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD

(Homo sapiens) 		PF00619
(CARD)
PF02758
(PYRIN) 		3 ALA A  11
ASN A  14
LEU A  15
 None
 0.35A 5i1pA-2kn6A:
undetectable		 5i1pA-2kn6A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n4k ENTEROCIN-HF

(Enterococcus
faecium) 		PF01721
(Bacteriocin_II) 		3 ALA A  29
ASN A  32
LEU A  33
 None
 0.38A 5i1pA-2n4kA:
undetectable		 5i1pA-2n4kA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00106
(adh_short) 		3 ALA A  68
ASN A  71
LEU A  72
 None
 0.35A 5i1pA-2nwqA:
undetectable		 5i1pA-2nwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfi CHLORIDE CHANNEL
PROTEIN CLC-KA

(Homo sapiens) 		PF00571
(CBS) 		3 ALA A 676
ASN A 679
LEU A 680
 CL  A 504 ( 4.2A)
CL  A 504 ( 4.8A)
None
 0.26A 5i1pA-2pfiA:
undetectable		 5i1pA-2pfiA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo sapiens) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		3 ALA A 286
ASN A 289
LEU A 290
 None
 0.38A 5i1pA-2pkgA:
undetectable		 5i1pA-2pkgA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qb6 EXOPOLYPHOSPHATASE

(Saccharomyces
cerevisiae) 		PF01368
(DHH)
PF02833
(DHHA2) 		3 ALA A 391
ASN A 394
LEU A 395
 None
 0.14A 5i1pA-2qb6A:
undetectable		 5i1pA-2qb6A:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ALA A 482
ASN A 485
LEU A 486
 None
 0.28A 5i1pA-2qt6A:
undetectable		 5i1pA-2qt6A:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5f ASPARTATE_TYROSINE_P
HENYLALANINE
PYRIDOXAL-5'
PHOSPHATE-DEPENDENT
AMINOTRANSFERASE

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		3 ALA A 250
ASN A 253
LEU A 254
 None
 0.20A 5i1pA-2x5fA:
undetectable		 5i1pA-2x5fA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afe HYDROXYLASE,
PUTATIVE

(Mycobacterium
tuberculosis) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		3 ALA A  15
ASN A  18
LEU A  19
 None
 0.27A 5i1pA-3afeA:
undetectable		 5i1pA-3afeA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr3 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
PHOSPHOTRANSFERASE
SUBUNIT DHAM

(Lactococcus
lactis) 		PF03610
(EIIA-man) 		3 ALA C  70
ASN C  73
LEU C  74
 None
 0.39A 5i1pA-3cr3C:
undetectable		 5i1pA-3cr3C:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d00 TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT E

(Syntrophus
aciditrophicus) 		PF02663
(FmdE) 		3 ALA A  39
ASN A  42
LEU A  43
 None
 0.22A 5i1pA-3d00A:
undetectable		 5i1pA-3d00A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7h DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Vibrio cholerae) 		no annotation 3 ALA A  94
ASN A  97
LEU A  98
 None
 0.32A 5i1pA-3e7hA:
undetectable		 5i1pA-3e7hA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcd LYASE

(uncultured
bacterium) 		no annotation 3 ALA A  85
ASN A  88
LEU A  89
 None
 0.36A 5i1pA-3fcdA:
undetectable		 5i1pA-3fcdA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj1 PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Ruegeria
pomeroyi) 		PF01380
(SIS) 		3 ALA A 178
ASN A 181
LEU A 182
 None
 0.29A 5i1pA-3fj1A:
undetectable		 5i1pA-3fj1A:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6p ESAT-6 LIKE PROTEIN
ESXS

(Mycobacterium
tuberculosis) 		PF06013
(WXG100) 		3 ALA A  72
ASN A  75
LEU A  76
 None
 0.27A 5i1pA-3h6pA:
undetectable		 5i1pA-3h6pA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsy GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		3 ALA A 289
ASN A 292
LEU A 293
 None
 0.39A 5i1pA-3hsyA:
undetectable		 5i1pA-3hsyA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hww 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Escherichia
coli) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		3 ALA A  82
ASN A  85
LEU A  86
 NA  A 564 (-3.2A)
None
None
 0.38A 5i1pA-3hwwA:
undetectable		 5i1pA-3hwwA:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k85 D-GLYCERO-D-MANNO-HE
PTOSE 1-PHOSPHATE
KINASE

(Bacteroides
thetaiotaomicron) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 ALA A 317
ASN A 320
LEU A 321
 None
 0.21A 5i1pA-3k85A:
undetectable		 5i1pA-3k85A:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzn GLUCARATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF13378
(MR_MLE_C) 		3 ALA A 183
ASN A 186
LEU A 187
 None
 0.35A 5i1pA-3mznA:
undetectable		 5i1pA-3mznA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF02645
(DegV) 		3 ALA A 241
ASN A 244
LEU A 245
 None
 0.37A 5i1pA-3pl5A:
undetectable		 5i1pA-3pl5A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skp SEROTRANSFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 ALA A 658
ASN A 661
LEU A 662
 None
 0.38A 5i1pA-3skpA:
undetectable		 5i1pA-3skpA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE

(Helicobacter
pylori) 		PF01370
(Epimerase) 		3 ALA A 118
ASN A 121
LEU A 122
 None
 0.39A 5i1pA-3sxpA:
undetectable		 5i1pA-3sxpA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ALA A 483
ASN A 486
LEU A 487
 None
 0.27A 5i1pA-3t6wA:
undetectable		 5i1pA-3t6wA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr0 GUANYLATE KINASE

(Coxiella
burnetii) 		PF00625
(Guanylate_kin) 		3 ALA A 173
ASN A 176
LEU A 177
 None
 0.37A 5i1pA-3tr0A:
undetectable		 5i1pA-3tr0A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v6a APOPTOSIS INHIBITOR
5

(Homo sapiens) 		PF05918
(API5) 		3 ALA A 112
ASN A 115
LEU A 116
 None
 0.39A 5i1pA-3v6aA:
undetectable		 5i1pA-3v6aA:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b18 IMPORTIN SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		3 ALA A 235
ASN A 238
LEU A 239
 None
 0.22A 5i1pA-4b18A:
undetectable		 5i1pA-4b18A:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9i DIAMINOPROPIONATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00291
(PALP) 		3 ALA A 153
ASN A 156
LEU A 157
 None
 0.35A 5i1pA-4d9iA:
undetectable		 5i1pA-4d9iA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvg DIAPHANOUS PROTEIN

(Entamoeba
histolytica) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		3 ALA B 273
ASN B 276
LEU B 277
 None
 0.32A 5i1pA-4dvgB:
undetectable		 5i1pA-4dvgB:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4t PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Burkholderia
ambifaria) 		PF02222
(ATP-grasp) 		3 ALA A 228
ASN A 324
LEU A 323
 None
 0.38A 5i1pA-4e4tA:
undetectable		 5i1pA-4e4tA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqq PUTATIVE HOST CELL
SURFACE-EXPOSED
LIPOPROTEIN

(Streptococcus
phage TP-J34) 		PF07553
(Lipoprotein_Ltp) 		3 ALA A 137
ASN A 140
LEU A 141
 None
 0.35A 5i1pA-4eqqA:
undetectable		 5i1pA-4eqqA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fay MICROCOMPARTMENTS
PROTEIN

(Lactobacillus
reuteri) 		PF00936
(BMC) 		3 ALA A 111
ASN A 114
LEU A 115
 None
 0.26A 5i1pA-4fayA:
undetectable		 5i1pA-4fayA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsc STREPTOLYSIN O

(Streptococcus
pyogenes) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		3 ALA X 228
ASN X 231
LEU X 232
 None
 0.38A 5i1pA-4hscX:
undetectable		 5i1pA-4hscX:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4s NUCLEOCAPSID PROTEIN

(SFTS
phlebovirus) 		PF05733
(Tenui_N) 		3 ALA A 131
ASN A 134
LEU A 135
 None
 0.31A 5i1pA-4j4sA:
undetectable		 5i1pA-4j4sA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jiu PROABYLYSIN

(Pyrococcus
abyssi) 		PF01863
(DUF45) 		3 ALA A  45
ASN A  48
LEU A  49
 None
 0.27A 5i1pA-4jiuA:
undetectable		 5i1pA-4jiuA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		3 ALA A 768
ASN A 771
LEU A 772
 None
 0.18A 5i1pA-4k0eA:
undetectable		 5i1pA-4k0eA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvc CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A

(Rattus
norvegicus) 		PF01467
(CTP_transf_like) 		3 ALA A 217
ASN A 220
LEU A 221
 None
 0.32A 5i1pA-4mvcA:
undetectable		 5i1pA-4mvcA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6s C-PHYCOCYANIN BETA
SUBUNIT

(Thermosynechococcus
vulcanus) 		PF00502
(Phycobilisome) 		3 ALA B  26
ASN B  29
LEU B  30
 None
 0.26A 5i1pA-4n6sB:
undetectable		 5i1pA-4n6sB:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nlb RIBOSOMAL RNA
PROCESSING PROTEIN 6

(Trypanosoma
brucei) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		3 ALA A 350
ASN A 353
LEU A 354
 None
 0.39A 5i1pA-4nlbA:
undetectable		 5i1pA-4nlbA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oet PUTATIVE PEPTIDE
ABC-TRANSPORT SYSTEM
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF00496
(SBP_bac_5) 		3 ALA A  28
ASN A  31
LEU A  32
 None
 0.38A 5i1pA-4oetA:
undetectable		 5i1pA-4oetA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY

(Shewanella
oneidensis) 		PF07804
(HipA_C)
PF13657
(Couple_hipA) 		3 ALA A 296
ASN A 299
LEU A 300
 None
 0.37A 5i1pA-4pu5A:
undetectable		 5i1pA-4pu5A:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmh LP04448P

(Drosophila
melanogaster) 		PF12348
(CLASP_N) 		3 ALA A1079
ASN A1082
LEU A1083
 None
 0.32A 5i1pA-4qmhA:
undetectable		 5i1pA-4qmhA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn1 E3 UBIQUITIN-PROTEIN
LIGASE SHPRH

(Homo sapiens) 		no annotation 3 ALA A1210
ASN A1213
LEU A1214
 None
 0.34A 5i1pA-4qn1A:
undetectable		 5i1pA-4qn1A:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpc PUTATIVE ALPHA/BETA
HYDROLASE

(Desulfitobacterium
hafniense) 		PF12697
(Abhydrolase_6) 		3 ALA A 137
ASN A 140
LEU A 141
 None
 0.20A 5i1pA-4rpcA:
undetectable		 5i1pA-4rpcA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnm IMPORTIN SUBUNIT
ALPHA

(Arabidopsis
thaliana) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		3 ALA A 448
ASN A 451
LEU A 452
 None
 0.37A 5i1pA-4tnmA:
undetectable		 5i1pA-4tnmA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		3 ALA A 110
ASN A 113
LEU A 114
 None
 0.38A 5i1pA-4u1rA:
undetectable		 5i1pA-4u1rA:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uad IMPORTIN SUBUNIT
ALPHA-7

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		3 ALA A 233
ASN A 236
LEU A 237
 None
 0.35A 5i1pA-4uadA:
undetectable		 5i1pA-4uadA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wh0 PUTATIVE HYDROLASE

(Pseudomonas
aeruginosa) 		PF00857
(Isochorismatase) 		3 ALA A 193
ASN A 196
LEU A 197
 None
 0.35A 5i1pA-4wh0A:
undetectable		 5i1pA-4wh0A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xky DIHYDRODIPICOLINATE
SYNTHASE

(Bacteroides
thetaiotaomicron) 		PF00701
(DHDPS) 		3 ALA A 294
ASN A 297
LEU A 298
 None
 0.20A 5i1pA-4xkyA:
undetectable		 5i1pA-4xkyA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yet SUPEROXIDE DISMUTASE

(Babesia bovis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 ALA A 188
ASN A 191
LEU A 192
 None
 0.31A 5i1pA-4yetA:
undetectable		 5i1pA-4yetA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE

(Streptococcus
pneumoniae) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		3 ALA A1401
ASN A1404
LEU A1405
 None
 0.35A 5i1pA-4z3oA:
undetectable		 5i1pA-4z3oA:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aeb LRA-12

(uncultured
bacterium BLR12) 		PF00753
(Lactamase_B) 		3 ALA A 249
ASN A 252
LEU A 254
 None
 0.24A 5i1pA-5aebA:
undetectable		 5i1pA-5aebA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT

(Corynebacterium
glutamicum) 		PF01497
(Peripla_BP_2) 		3 ALA A 147
ASN A 150
LEU A 151
 None
 0.30A 5i1pA-5az3A:
undetectable		 5i1pA-5az3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c05 PUTATIVE
GAMMA-TERPINENE
SYNTHASE

(Thymus vulgaris) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 ALA A 558
ASN A 561
LEU A 562
 ALA  A 558 ( 0.0A)
ASN  A 561 ( 0.6A)
LEU  A 562 ( 0.6A)
 0.36A 5i1pA-5c05A:
undetectable		 5i1pA-5c05A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c30 RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF02026
(RyR) 		3 ALA A 946
ASN A 949
LEU A 950
 None
 0.25A 5i1pA-5c30A:
undetectable		 5i1pA-5c30A:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cl2 SPORULATION-CONTROL
PROTEIN SPO0M

(Bacillus
subtilis) 		PF07070
(Spo0M) 		3 ALA A 146
ASN A 149
LEU A 150
 None
 0.37A 5i1pA-5cl2A:
undetectable		 5i1pA-5cl2A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eoe BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		3 ALA A 126
ASN A 129
LEU A 130
 None
 0.36A 5i1pA-5eoeA:
undetectable		 5i1pA-5eoeA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdh TOLL-LIKE RECEPTOR 8

(Homo sapiens) 		PF13855
(LRR_8) 		3 ALA A 658
ASN A 661
LEU A 662
 None
 0.30A 5i1pA-5hdhA:
undetectable		 5i1pA-5hdhA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ibk F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7

(Homo sapiens) 		PF12937
(F-box-like) 		3 ALA B 315
ASN B 318
LEU B 319
 None
 0.38A 5i1pA-5ibkB:
undetectable		 5i1pA-5ibkB:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihe DNA POLYMERASE II
SMALL SUBUNIT

(Pyrococcus
abyssi) 		PF00149
(Metallophos) 		3 ALA A 430
ASN A 433
LEU A 434
 None
 0.36A 5i1pA-5iheA:
undetectable		 5i1pA-5iheA:
9.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j4a TRNA NUCLEASE CDIA

(Burkholderia
pseudomallei) 		no annotation 3 ALA A 300
ASN A 303
LEU A 304
 None
 0.16A 5i1pA-5j4aA:
undetectable		 5i1pA-5j4aA:
31.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfq GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Geoglobus
acetivorans) 		PF00348
(polyprenyl_synt) 		3 ALA A 291
ASN A 294
LEU A 295
 None
 0.39A 5i1pA-5jfqA:
undetectable		 5i1pA-5jfqA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnb UBIQUITIN-LIKE-SPECI
FIC PROTEASE 2

(Saccharomyces
cerevisiae) 		PF02902
(Peptidase_C48) 		3 ALA B 268
ASN B 271
LEU B 272
 None
 0.38A 5i1pA-5lnbB:
undetectable		 5i1pA-5lnbB:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PUTATIVE PRE-MRNA
SPLICING FACTOR

(Chaetomium
thermophilum) 		PF08084
(PROCT) 		3 ALA B2052
ASN B2055
LEU B2056
 None
 0.32A 5i1pA-5m59B:
undetectable		 5i1pA-5m59B:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Psychrobacter
arcticus) 		PF13393
(tRNA-synt_His) 		3 ALA A 332
ASN A 335
LEU A 336
 None
 0.19A 5i1pA-5m8hA:
undetectable		 5i1pA-5m8hA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n3u PHYCOCYANOBILIN
LYASE SUBUNIT ALPHA

(Nostoc sp. PCC
7120) 		no annotation 3 ALA A  22
ASN A  25
LEU A  26
 None
 0.27A 5i1pA-5n3uA:
undetectable		 5i1pA-5n3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5och -

(-) 		no annotation 3 ALA B 714
ASN B 717
LEU B 718
 None
 0.27A 5i1pA-5ochB:
undetectable		 5i1pA-5ochB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT B

(Methanothermococcus
thermolithotrophicus) 		PF02754
(CCG) 		3 ALA B  60
ASN B  63
LEU B  64
 None
 0.38A 5i1pA-5odrB:
undetectable		 5i1pA-5odrB:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5van BETA-KLOTHO

(Homo sapiens) 		no annotation 3 ALA A 711
ASN A 714
LEU A 715
 None
 0.39A 5i1pA-5vanA:
undetectable		 5i1pA-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn6 TAURINE DIOXYGENASE

(Burkholderia
ambifaria) 		PF02668
(TauD) 		3 ALA A 133
ASN A 136
LEU A 137
 None
 0.36A 5i1pA-5vn6A:
undetectable		 5i1pA-5vn6A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8d AUTOINDUCER SYNTHASE

(Bradyrhizobium
japonicum) 		PF00765
(Autoind_synth) 		3 ALA A 204
ASN A 207
LEU A 208
 None
 0.35A 5i1pA-5w8dA:
undetectable		 5i1pA-5w8dA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		3 ALA A 295
ASN A 298
LEU A 299
 None
 0.39A 5i1pA-5weoA:
undetectable		 5i1pA-5weoA:
3.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wti CRISPR-ASSOCIATED
PROTEIN

(Bacillus
thermoamylovorans) 		no annotation 3 ALA Z 955
ASN Z 958
LEU Z 959
 None
 0.32A 5i1pA-5wtiZ:
undetectable		 5i1pA-5wtiZ:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 ALA B1054
ASN B1057
LEU B1058
 None
 0.37A 5i1pA-5xogB:
undetectable		 5i1pA-5xogB:
3.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0s THERMOTOGA MARITIMA
TMCAL

(Thermotoga
maritima) 		no annotation 3 ALA A 212
ASN A 215
LEU A 216
 None
 0.32A 5i1pA-5y0sA:
undetectable		 5i1pA-5y0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6acd -

(-) 		no annotation 3 ALA A1002
ASN A1005
LEU A1006
 None
 0.39A 5i1pA-6acdA:
undetectable		 5i1pA-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6an0 HISTIDINOL
DEHYDROGENASE

(Elizabethkingia
anophelis) 		PF00815
(Histidinol_dh) 		3 ALA A 314
ASN A 317
LEU A 318
 None
 0.39A 5i1pA-6an0A:
undetectable		 5i1pA-6an0A:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cet GATOR COMPLEX
PROTEIN NPRL2

(Homo sapiens) 		no annotation 3 ALA N 223
ASN N 226
LEU N 227
 None
 0.36A 5i1pA-6cetN:
undetectable		 5i1pA-6cetN:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6egx STRUCTURAL PROTEIN
VP1

(Sacbrood virus) 		no annotation 3 ALA A  89
ASN A  92
LEU A  93
 None
 0.37A 5i1pA-6egxA:
undetectable		 5i1pA-6egxA:
undetectable