SIMILAR PATTERNS OF AMINO ACIDS FOR 5I1O_H_DVAH9

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aq0 1,3-1,4-BETA-GLUCANA
SE

(Hordeum vulgare) 		PF00332
(Glyco_hydro_17) 		3 ALA A  98
ASN A 101
LEU A 102
 None
 0.42A 5i1oA-1aq0A:
0.0		 5i1oA-1aq0A:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bik BIKUNIN

(Homo sapiens) 		PF00014
(Kunitz_BPTI) 		3 ALA A  80
ASN A  83
LEU A  84
 None
 0.27A 5i1oA-1bikA:
undetectable		 5i1oA-1bikA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		3 ALA A 327
ASN A 330
LEU A 331
 None
 0.34A 5i1oA-1biyA:
0.0		 5i1oA-1biyA:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by1 PROTEIN (PIX)

(Homo sapiens) 		PF00621
(RhoGEF) 		3 ALA A 182
ASN A 185
LEU A 186
 None
 0.45A 5i1oA-1by1A:
0.0		 5i1oA-1by1A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE

(Lactobacillus
casei) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 ALA A 218
ASN A 221
LEU A 222
 None
 0.42A 5i1oA-1dxyA:
0.0		 5i1oA-1dxyA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyy ALDEHYDE
DEHYDROGENASE

(Vibrio harveyi) 		PF00171
(Aldedh) 		3 ALA A 236
ASN A 239
LEU A 240
 NAP  A 650 ( 4.1A)
None
None
 0.49A 5i1oA-1eyyA:
0.0		 5i1oA-1eyyA:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fep FERRIC ENTEROBACTIN
RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ALA A  19
ASN A  22
LEU A  23
 None
 0.45A 5i1oA-1fepA:
0.0		 5i1oA-1fepA:
4.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE

(Pseudomonas
putida) 		PF00221
(Lyase_aromatic) 		3 ALA A 337
ASN A 340
LEU A 341
 None
 0.46A 5i1oA-1gk2A:
0.0		 5i1oA-1gk2A:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h76 SEROTRANSFERRIN

(Sus scrofa) 		PF00405
(Transferrin) 		3 ALA A 326
ASN A 329
LEU A 330
 None
 0.50A 5i1oA-1h76A:
undetectable		 5i1oA-1h76A:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF01702
(TGT)
PF14809
(TGT_C1)
PF14810
(TGT_C2) 		3 ALA A 305
ASN A 308
LEU A 309
 None
 0.50A 5i1oA-1j2bA:
undetectable		 5i1oA-1j2bA:
4.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j9m DD-TRANSPEPTIDASE

(Streptomyces
sp. K15) 		PF00768
(Peptidase_S11) 		3 ALA A 128
ASN A 131
LEU A 132
 None
 0.46A 5i1oA-1j9mA:
undetectable		 5i1oA-1j9mA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ALA A 330
ASN A 333
LEU A 334
 None
 0.37A 5i1oA-1jvbA:
undetectable		 5i1oA-1jvbA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq0 METHIONINE
AMINOPEPTIDASE 2

(Homo sapiens) 		PF00557
(Peptidase_M24) 		3 ALA A 431
ASN A 434
LEU A 435
 None
 0.49A 5i1oA-1kq0A:
undetectable		 5i1oA-1kq0A:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 ALA A 327
ASN A 330
LEU A 331
 None
 0.20A 5i1oA-1n76A:
undetectable		 5i1oA-1n76A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o3x ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA1

(Homo sapiens) 		PF03127
(GAT) 		3 ALA A 283
ASN A 286
LEU A 287
 None
 0.38A 5i1oA-1o3xA:
undetectable		 5i1oA-1o3xA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		3 ALA A 237
ASN A 240
LEU A 241
 None
 0.45A 5i1oA-1qgrA:
undetectable		 5i1oA-1qgrA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjm LACTOFERRIN

(Equus caballus) 		PF00405
(Transferrin) 		3 ALA A 327
ASN A 330
LEU A 331
 None
 0.51A 5i1oA-1qjmA:
undetectable		 5i1oA-1qjmA:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2f PROTEIN
(RIBONUCLEOTIDE
REDUCTASE R2)

(Salmonella
enterica) 		PF00268
(Ribonuc_red_sm) 		3 ALA A 261
ASN A 264
LEU A 265
 None
 0.47A 5i1oA-1r2fA:
undetectable		 5i1oA-1r2fA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1

(Saccharomyces
cerevisiae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		3 ALA A 133
ASN A 132
LEU A 131
 None
 0.47A 5i1oA-1ry2A:
undetectable		 5i1oA-1ry2A:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sny SNIFFER CG10964-PA

(Drosophila
melanogaster) 		PF00106
(adh_short) 		3 ALA A  21
ASN A  24
LEU A  25
 None
 0.26A 5i1oA-1snyA:
undetectable		 5i1oA-1snyA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		3 ALA A 470
ASN A 473
LEU A 474
 None
 0.50A 5i1oA-1v4gA:
undetectable		 5i1oA-1v4gA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Thermus
thermophilus) 		PF02350
(Epimerase_2) 		3 ALA A 157
ASN A 160
LEU A 161
 None
 0.46A 5i1oA-1v4vA:
undetectable		 5i1oA-1v4vA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl4 PMBA-RELATED PROTEIN

(Thermotoga
maritima) 		PF01523
(PmbA_TldD) 		3 ALA A  79
ASN A  82
LEU A  83
 None
 0.37A 5i1oA-1vl4A:
undetectable		 5i1oA-1vl4A:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wr6 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3

(Homo sapiens) 		PF03127
(GAT) 		3 ALA A 282
ASN A 285
LEU A 286
 None
 0.47A 5i1oA-1wr6A:
undetectable		 5i1oA-1wr6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zp6 HYPOTHETICAL PROTEIN
ATU3015

(Agrobacterium
fabrum) 		PF13238
(AAA_18) 		3 ALA A  28
ASN A  31
LEU A  32
 None
 0.43A 5i1oA-1zp6A:
undetectable		 5i1oA-1zp6A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		3 ALA A 179
ASN A 182
LEU A 183
 None
 0.42A 5i1oA-2a14A:
undetectable		 5i1oA-2a14A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adu METHIONINE
AMINOPEPTIDASE 2

(Homo sapiens) 		PF00557
(Peptidase_M24) 		3 ALA A 431
ASN A 434
LEU A 435
 None
 0.42A 5i1oA-2aduA:
undetectable		 5i1oA-2aduA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as0 HYPOTHETICAL PROTEIN
PH1915

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF10672
(Methyltrans_SAM) 		3 ALA A 320
ASN A 323
LEU A 324
 None
 0.51A 5i1oA-2as0A:
undetectable		 5i1oA-2as0A:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP3 CORE
PROTEIN)

(Bluetongue
virus) 		PF01700
(Orbi_VP3) 		3 ALA A 650
ASN A 653
LEU A 654
 None
 0.26A 5i1oA-2btvA:
undetectable		 5i1oA-2btvA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw3 IRON SUPEROXIDE
DISMUTASE

(Perkinsus
marinus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 ALA A 199
ASN A 202
LEU A 203
 None
 0.26A 5i1oA-2cw3A:
undetectable		 5i1oA-2cw3A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ALA A 330
ASN A 333
LEU A 334
 None
None
NAD  A 401 (-3.6A)
 0.37A 5i1oA-2eerA:
undetectable		 5i1oA-2eerA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE

(Azoarcus) 		PF13561
(adh_short_C2) 		3 ALA A  48
ASN A  51
LEU A  52
 None
 0.35A 5i1oA-2ewmA:
undetectable		 5i1oA-2ewmA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hau SEROTRANSFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 ALA A 322
ASN A 325
LEU A 326
 None
 0.51A 5i1oA-2hauA:
undetectable		 5i1oA-2hauA:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsj PUTATIVE PLATELET
ACTIVATING FACTOR

(Streptococcus
pneumoniae) 		PF13472
(Lipase_GDSL_2) 		3 ALA A 104
ASN A 107
LEU A 108
 None
 0.46A 5i1oA-2hsjA:
undetectable		 5i1oA-2hsjA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iip NICOTINAMIDE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		3 ALA A 179
ASN A 182
LEU A 183
 None
 0.48A 5i1oA-2iipA:
undetectable		 5i1oA-2iipA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqi HYPOTHETICAL PROTEIN
XCC0632

(Xanthomonas
campestris) 		PF03886
(ABC_trans_aux) 		3 ALA A 150
ASN A 149
LEU A 148
 None
 0.44A 5i1oA-2iqiA:
undetectable		 5i1oA-2iqiA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kn6 APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD

(Homo sapiens) 		PF00619
(CARD)
PF02758
(PYRIN) 		3 ALA A  11
ASN A  14
LEU A  15
 None
 0.30A 5i1oA-2kn6A:
undetectable		 5i1oA-2kn6A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n1f APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN

(Mus musculus) 		PF02758
(PYRIN) 		3 ALA A  11
ASN A  14
LEU A  15
 None
 0.30A 5i1oA-2n1fA:
undetectable		 5i1oA-2n1fA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n4k ENTEROCIN-HF

(Enterococcus
faecium) 		PF01721
(Bacteriocin_II) 		3 ALA A  29
ASN A  32
LEU A  33
 None
 0.46A 5i1oA-2n4kA:
undetectable		 5i1oA-2n4kA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nsg HYPOTHETICAL PROTEIN
CGL3021

(Corynebacterium
glutamicum) 		PF11716
(MDMPI_N) 		3 ALA A  59
ASN A  62
LEU A  63
 None
 0.39A 5i1oA-2nsgA:
undetectable		 5i1oA-2nsgA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxl HYPOTHETICAL PROTEIN
YMGB

(Escherichia
coli) 		PF10798
(YmgB) 		3 ALA A  37
ASN A  40
LEU A  41
 None
 0.51A 5i1oA-2oxlA:
undetectable		 5i1oA-2oxlA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pae DTDP-6-DEOXY-3,4-KET
O-HEXULOSE ISOMERASE

(Aneurinibacillus
thermoaerophilus) 		PF05523
(FdtA) 		3 ALA A 131
ASN A 134
LEU A 135
 None
 0.46A 5i1oA-2paeA:
undetectable		 5i1oA-2paeA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfi CHLORIDE CHANNEL
PROTEIN CLC-KA

(Homo sapiens) 		PF00571
(CBS) 		3 ALA A 676
ASN A 679
LEU A 680
 CL  A 504 ( 4.2A)
CL  A 504 ( 4.8A)
None
 0.26A 5i1oA-2pfiA:
undetectable		 5i1oA-2pfiA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfk 6-PHOSPHOFRUCTOKINAS
E ISOZYME I

(Escherichia
coli) 		PF00365
(PFK) 		3 ALA A  85
ASN A  88
LEU A  89
 None
 0.50A 5i1oA-2pfkA:
undetectable		 5i1oA-2pfkA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE

(Nostoc
punctiforme) 		PF00497
(SBP_bac_3) 		3 ALA A 201
ASN A 204
LEU A 205
 None
 0.49A 5i1oA-2pyyA:
undetectable		 5i1oA-2pyyA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qb6 EXOPOLYPHOSPHATASE

(Saccharomyces
cerevisiae) 		PF01368
(DHH)
PF02833
(DHHA2) 		3 ALA A 391
ASN A 394
LEU A 395
 None
 0.43A 5i1oA-2qb6A:
undetectable		 5i1oA-2qb6A:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qna IMPORTIN SUBUNIT
BETA-1

(Homo sapiens) 		PF13513
(HEAT_EZ) 		3 ALA A 237
ASN A 240
LEU A 241
 None
 0.39A 5i1oA-2qnaA:
undetectable		 5i1oA-2qnaA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ALA A 482
ASN A 485
LEU A 486
 None
 0.33A 5i1oA-2qt6A:
undetectable		 5i1oA-2qt6A:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vak SIGMA A

(Avian
orthoreovirus) 		PF03084
(Sigma_1_2) 		3 ALA A 295
ASN A 298
LEU A 299
 None
 0.45A 5i1oA-2vakA:
undetectable		 5i1oA-2vakA:
5.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vea PHYTOCHROME-LIKE
PROTEIN CPH1

(Synechocystis
sp. PCC 6803) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		3 ALA A 503
ASN A 506
LEU A 507
 None
 0.46A 5i1oA-2veaA:
undetectable		 5i1oA-2veaA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrs SIGMA-C CAPSID
PROTEIN

(Avian
orthoreovirus) 		PF04582
(Reo_sigmaC) 		3 ALA A 127
ASN A 130
LEU A 131
 None
 0.41A 5i1oA-2vrsA:
undetectable		 5i1oA-2vrsA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6d DYNAMIN FAMILY
PROTEIN

(Nostoc
punctiforme) 		PF00350
(Dynamin_N) 		3 ALA A  61
ASN A  64
LEU A  65
 None
 0.47A 5i1oA-2w6dA:
undetectable		 5i1oA-2w6dA:
5.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqh CTPR3Y3

(synthetic
construct) 		PF13414
(TPR_11)
PF13432
(TPR_16) 		3 ALA A  11
ASN A  14
LEU A  15
 None
 0.50A 5i1oA-2wqhA:
undetectable		 5i1oA-2wqhA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5f ASPARTATE_TYROSINE_P
HENYLALANINE
PYRIDOXAL-5'
PHOSPHATE-DEPENDENT
AMINOTRANSFERASE

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		3 ALA A 250
ASN A 253
LEU A 254
 None
 0.39A 5i1oA-2x5fA:
undetectable		 5i1oA-2x5fA:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ysz AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 2
AND AMYLOID BETA A4
PROTEIN

(Mus musculus) 		PF00640
(PID)
PF10515
(APP_amyloid) 		3 ALA A  40
ASN A  43
LEU A  44
 None
 0.42A 5i1oA-2yszA:
undetectable		 5i1oA-2yszA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a69 FLAGELLAR HOOK
PROTEIN FLGE

(Salmonella
enterica) 		PF00460
(Flg_bb_rod)
PF06429
(Flg_bbr_C)
PF07559
(FlaE) 		3 ALA A  12
ASN A  15
LEU A  16
 None
 0.51A 5i1oA-3a69A:
undetectable		 5i1oA-3a69A:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afe HYDROXYLASE,
PUTATIVE

(Mycobacterium
tuberculosis) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		3 ALA A  15
ASN A  18
LEU A  19
 None
 0.44A 5i1oA-3afeA:
undetectable		 5i1oA-3afeA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2q UNCHARACTERIZED
CONSERVED PROTEIN

(Methanococcus
maripaludis) 		no annotation 3 ALA A 358
ASN A 361
LEU A 362
 None
 0.45A 5i1oA-3c2qA:
undetectable		 5i1oA-3c2qA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		3 ALA A  47
ASN A  50
LEU A  51
 None
 0.44A 5i1oA-3cghA:
undetectable		 5i1oA-3cghA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7a UPF0201 PROTEIN
PH1010

(Pyrococcus
horikoshii) 		PF01877
(RNA_binding) 		3 ALA A  26
ASN A  29
LEU A  30
 None
 0.35A 5i1oA-3d7aA:
undetectable		 5i1oA-3d7aA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 ALA A 558
ASN A 561
LEU A 562
 None
 0.50A 5i1oA-3dy5A:
undetectable		 5i1oA-3dy5A:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7h DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Vibrio cholerae) 		no annotation 3 ALA A  94
ASN A  97
LEU A  98
 None
 0.41A 5i1oA-3e7hA:
undetectable		 5i1oA-3e7hA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcd LYASE

(uncultured
bacterium) 		no annotation 3 ALA A  85
ASN A  88
LEU A  89
 None
 0.12A 5i1oA-3fcdA:
undetectable		 5i1oA-3fcdA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj1 PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Ruegeria
pomeroyi) 		PF01380
(SIS) 		3 ALA A 178
ASN A 181
LEU A 182
 None
 0.50A 5i1oA-3fj1A:
undetectable		 5i1oA-3fj1A:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foa TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N) 		3 ALA A 422
ASN A 425
LEU A 426
 None
 0.48A 5i1oA-3foaA:
undetectable		 5i1oA-3foaA:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 ALA B   4
ASN B   7
LEU B   8
 None
 0.25A 5i1oA-3hhsB:
undetectable		 5i1oA-3hhsB:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hur ALANINE RACEMASE

(Oenococcus oeni) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 ALA A  18
ASN A  21
LEU A  22
 None
 0.43A 5i1oA-3hurA:
undetectable		 5i1oA-3hurA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hww 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Escherichia
coli) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		3 ALA A  82
ASN A  85
LEU A  86
 NA  A 564 (-3.2A)
None
None
 0.36A 5i1oA-3hwwA:
undetectable		 5i1oA-3hwwA:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2d E3 SUMO-PROTEIN
LIGASE SIZ1

(Saccharomyces
cerevisiae) 		PF02891
(zf-MIZ)
PF14324
(PINIT) 		3 ALA A 214
ASN A 217
LEU A 218
 None
 0.51A 5i1oA-3i2dA:
undetectable		 5i1oA-3i2dA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2n TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		3 ALA U 422
ASN U 425
LEU U 426
 None
 0.49A 5i1oA-3j2nU:
undetectable		 5i1oA-3j2nU:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k85 D-GLYCERO-D-MANNO-HE
PTOSE 1-PHOSPHATE
KINASE

(Bacteroides
thetaiotaomicron) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 ALA A 317
ASN A 320
LEU A 321
 None
 0.31A 5i1oA-3k85A:
undetectable		 5i1oA-3k85A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb6 D-LACTATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 ALA A 273
ASN A 277
LEU A 278
 None
 0.49A 5i1oA-3kb6A:
undetectable		 5i1oA-3kb6A:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll3 GLUCONATE KINASE

(Lactobacillus
acidophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ALA A 381
ASN A 384
LEU A 385
 None
 0.29A 5i1oA-3ll3A:
undetectable		 5i1oA-3ll3A:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjo RIBONUCLEOTIDE
REDUCTASE SUBUNIT
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		3 ALA A 271
ASN A 274
LEU A 275
 None
 0.49A 5i1oA-3mjoA:
undetectable		 5i1oA-3mjoA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzn GLUCARATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF13378
(MR_MLE_C) 		3 ALA A 183
ASN A 186
LEU A 187
 None
 0.43A 5i1oA-3mznA:
undetectable		 5i1oA-3mznA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3b RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
SUBUNIT BETA

(Escherichia
coli) 		no annotation 3 ALA B 261
ASN B 264
LEU B 265
 None
PEO  B 322 ( 4.4A)
None
 0.44A 5i1oA-3n3bB:
undetectable		 5i1oA-3n3bB:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nk4 ZONA PELLUCIDA 3

(Gallus gallus) 		PF00100
(Zona_pellucida) 		3 ALA A  97
ASN A  96
LEU A  95
 None
 0.49A 5i1oA-3nk4A:
undetectable		 5i1oA-3nk4A:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		3 ALA A 101
ASN A 104
LEU A 105
 None
 0.48A 5i1oA-3o8lA:
undetectable		 5i1oA-3o8lA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		3 ALA A 291
ASN A 294
LEU A 295
 None
 0.46A 5i1oA-3o8oA:
undetectable		 5i1oA-3o8oA:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oh8 NUCLEOSIDE-DIPHOSPHA
TE SUGAR EPIMERASE
(SULA FAMILY)

(Corynebacterium
glutamicum) 		PF01370
(Epimerase)
PF08338
(DUF1731) 		3 ALA A 419
ASN A 422
LEU A 423
 None
 0.50A 5i1oA-3oh8A:
undetectable		 5i1oA-3oh8A:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot5 UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Listeria
monocytogenes) 		PF02350
(Epimerase_2) 		3 ALA A 156
ASN A 159
LEU A 160
 None
 0.45A 5i1oA-3ot5A:
undetectable		 5i1oA-3ot5A:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozv FLAVOHEMOGLOBIN

(Cupriavidus
necator) 		no annotation 3 ALA B 380
ASN B 383
LEU B 384
 None
 0.45A 5i1oA-3ozvB:
undetectable		 5i1oA-3ozvB:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0s CAPSID PROTEIN VP

(Lepidopteran
iteradensovirus
1) 		PF01057
(Parvo_NS1) 		3 ALA A 336
ASN A 339
LEU A 340
 None
 0.32A 5i1oA-3p0sA:
undetectable		 5i1oA-3p0sA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF02645
(DegV) 		3 ALA A 241
ASN A 244
LEU A 245
 None
 0.37A 5i1oA-3pl5A:
undetectable		 5i1oA-3pl5A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skp SEROTRANSFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 ALA A 658
ASN A 661
LEU A 662
 None
 0.49A 5i1oA-3skpA:
undetectable		 5i1oA-3skpA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE

(Helicobacter
pylori) 		PF01370
(Epimerase) 		3 ALA A 118
ASN A 121
LEU A 122
 None
 0.42A 5i1oA-3sxpA:
undetectable		 5i1oA-3sxpA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ALA A 483
ASN A 486
LEU A 487
 None
 0.31A 5i1oA-3t6wA:
undetectable		 5i1oA-3t6wA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr0 GUANYLATE KINASE

(Coxiella
burnetii) 		PF00625
(Guanylate_kin) 		3 ALA A 173
ASN A 176
LEU A 177
 None
 0.48A 5i1oA-3tr0A:
undetectable		 5i1oA-3tr0A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u62 SHIKIMATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		3 ALA A 229
ASN A 232
LEU A 233
 None
 0.51A 5i1oA-3u62A:
undetectable		 5i1oA-3u62A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrf NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bifidobacterium
longum) 		PF07944
(Glyco_hydro_127) 		3 ALA A  53
ASN A  56
LEU A  57
 None
 0.44A 5i1oA-3wrfA:
undetectable		 5i1oA-3wrfA:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1s PARTNER OF
INSCUTEABLE

(Drosophila
melanogaster) 		PF13176
(TPR_7)
PF13424
(TPR_12) 		3 ALA A 163
ASN A 166
LEU A 167
 None
 0.49A 5i1oA-4a1sA:
undetectable		 5i1oA-4a1sA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b18 IMPORTIN SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		3 ALA A 235
ASN A 238
LEU A 239
 None
 0.48A 5i1oA-4b18A:
undetectable		 5i1oA-4b18A:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA

(Drosophila
melanogaster;
Eptatretus
burgeri) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		3 ALA R 328
ASN R 352
LEU R 353
 None
 0.51A 5i1oA-4bv4R:
undetectable		 5i1oA-4bv4R:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		3 ALA A 208
ASN A 211
LEU A 212
 None
 0.45A 5i1oA-4cczA:
undetectable		 5i1oA-4cczA:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgr PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		3 ALA A 216
ASN A 219
LEU A 220
 None
 0.43A 5i1oA-4cgrA:
undetectable		 5i1oA-4cgrA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8o ANKYRIN-2

(Homo sapiens) 		PF00531
(Death)
PF00791
(ZU5) 		3 ALA A1510
ASN A1514
LEU A1515
 None
 0.41A 5i1oA-4d8oA:
undetectable		 5i1oA-4d8oA:
6.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9i DIAMINOPROPIONATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00291
(PALP) 		3 ALA A 153
ASN A 156
LEU A 157
 None
 0.46A 5i1oA-4d9iA:
undetectable		 5i1oA-4d9iA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dk1 PUTATIVE MACA,
MULTIDRUG RESISTANCE
PROTEIN MEXA

(Pseudomonas
aeruginosa;
Aggregatibacter
actinomycetemcomitans) 		PF16576
(HlyD_D23) 		3 ALA A 145
ASN A 148
LEU A 149
 None
 0.47A 5i1oA-4dk1A:
undetectable		 5i1oA-4dk1A:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dr0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus
subtilis) 		PF00268
(Ribonuc_red_sm) 		3 ALA A 267
ASN A 270
LEU A 271
 None
 0.50A 5i1oA-4dr0A:
undetectable		 5i1oA-4dr0A:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1

(Danio rerio) 		PF00079
(Serpin) 		3 ALA A 160
ASN A 159
LEU A 158
 None
 0.49A 5i1oA-4dteA:
undetectable		 5i1oA-4dteA:
8.93