SIMILAR PATTERNS OF AMINO ACIDS FOR 5I1N_G_DVAG9_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bik BIKUNIN

(Homo sapiens) 		PF00014
(Kunitz_BPTI) 		3 ALA A  80
ASN A  83
LEU A  84
 None
 0.25A 5i1nB-1bikA:
0.0		 5i1nB-1bikA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		3 ALA A 327
ASN A 330
LEU A 331
 None
 0.30A 5i1nB-1biyA:
0.0		 5i1nB-1biyA:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by1 PROTEIN (PIX)

(Homo sapiens) 		PF00621
(RhoGEF) 		3 ALA A 182
ASN A 185
LEU A 186
 None
 0.36A 5i1nB-1by1A:
0.0		 5i1nB-1by1A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE

(Lactobacillus
casei) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 ALA A 218
ASN A 221
LEU A 222
 None
 0.37A 5i1nB-1dxyA:
0.0		 5i1nB-1dxyA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fep FERRIC ENTEROBACTIN
RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ALA A  19
ASN A  22
LEU A  23
 None
 0.37A 5i1nB-1fepA:
0.0		 5i1nB-1fepA:
4.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ALA A 330
ASN A 333
LEU A 334
 None
 0.32A 5i1nB-1jvbA:
0.0		 5i1nB-1jvbA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 ALA A 327
ASN A 330
LEU A 331
 None
 0.16A 5i1nB-1n76A:
undetectable		 5i1nB-1n76A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o3x ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA1

(Homo sapiens) 		PF03127
(GAT) 		3 ALA A 283
ASN A 286
LEU A 287
 None
 0.35A 5i1nB-1o3xA:
0.1		 5i1nB-1o3xA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		3 ALA A 237
ASN A 240
LEU A 241
 None
 0.38A 5i1nB-1qgrA:
0.0		 5i1nB-1qgrA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2f PROTEIN
(RIBONUCLEOTIDE
REDUCTASE R2)

(Salmonella
enterica) 		PF00268
(Ribonuc_red_sm) 		3 ALA A 261
ASN A 264
LEU A 265
 None
 0.39A 5i1nB-1r2fA:
undetectable		 5i1nB-1r2fA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sny SNIFFER CG10964-PA

(Drosophila
melanogaster) 		PF00106
(adh_short) 		3 ALA A  21
ASN A  24
LEU A  25
 None
 0.28A 5i1nB-1snyA:
undetectable		 5i1nB-1snyA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Thermus
thermophilus) 		PF02350
(Epimerase_2) 		3 ALA A 157
ASN A 160
LEU A 161
 None
 0.40A 5i1nB-1v4vA:
undetectable		 5i1nB-1v4vA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl4 PMBA-RELATED PROTEIN

(Thermotoga
maritima) 		PF01523
(PmbA_TldD) 		3 ALA A  79
ASN A  82
LEU A  83
 None
 0.40A 5i1nB-1vl4A:
undetectable		 5i1nB-1vl4A:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		3 ALA A 179
ASN A 182
LEU A 183
 None
 0.37A 5i1nB-2a14A:
undetectable		 5i1nB-2a14A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adu METHIONINE
AMINOPEPTIDASE 2

(Homo sapiens) 		PF00557
(Peptidase_M24) 		3 ALA A 431
ASN A 434
LEU A 435
 None
 0.36A 5i1nB-2aduA:
undetectable		 5i1nB-2aduA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP3 CORE
PROTEIN)

(Bluetongue
virus) 		PF01700
(Orbi_VP3) 		3 ALA A 650
ASN A 653
LEU A 654
 None
 0.25A 5i1nB-2btvA:
undetectable		 5i1nB-2btvA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw3 IRON SUPEROXIDE
DISMUTASE

(Perkinsus
marinus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 ALA A 199
ASN A 202
LEU A 203
 None
 0.26A 5i1nB-2cw3A:
undetectable		 5i1nB-2cw3A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ALA A 330
ASN A 333
LEU A 334
 None
None
NAD  A 401 (-3.6A)
 0.34A 5i1nB-2eerA:
undetectable		 5i1nB-2eerA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE

(Azoarcus) 		PF13561
(adh_short_C2) 		3 ALA A  48
ASN A  51
LEU A  52
 None
 0.30A 5i1nB-2ewmA:
undetectable		 5i1nB-2ewmA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kn6 APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD

(Homo sapiens) 		PF00619
(CARD)
PF02758
(PYRIN) 		3 ALA A  11
ASN A  14
LEU A  15
 None
 0.24A 5i1nB-2kn6A:
undetectable		 5i1nB-2kn6A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n1f APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN

(Mus musculus) 		PF02758
(PYRIN) 		3 ALA A  11
ASN A  14
LEU A  15
 None
 0.35A 5i1nB-2n1fA:
undetectable		 5i1nB-2n1fA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n4k ENTEROCIN-HF

(Enterococcus
faecium) 		PF01721
(Bacteriocin_II) 		3 ALA A  29
ASN A  32
LEU A  33
 None
 0.39A 5i1nB-2n4kA:
undetectable		 5i1nB-2n4kA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nsg HYPOTHETICAL PROTEIN
CGL3021

(Corynebacterium
glutamicum) 		PF11716
(MDMPI_N) 		3 ALA A  59
ASN A  62
LEU A  63
 None
 0.35A 5i1nB-2nsgA:
undetectable		 5i1nB-2nsgA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pae DTDP-6-DEOXY-3,4-KET
O-HEXULOSE ISOMERASE

(Aneurinibacillus
thermoaerophilus) 		PF05523
(FdtA) 		3 ALA A 131
ASN A 134
LEU A 135
 None
 0.40A 5i1nB-2paeA:
undetectable		 5i1nB-2paeA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfi CHLORIDE CHANNEL
PROTEIN CLC-KA

(Homo sapiens) 		PF00571
(CBS) 		3 ALA A 676
ASN A 679
LEU A 680
 CL  A 504 ( 4.2A)
CL  A 504 ( 4.8A)
None
 0.23A 5i1nB-2pfiA:
undetectable		 5i1nB-2pfiA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qb6 EXOPOLYPHOSPHATASE

(Saccharomyces
cerevisiae) 		PF01368
(DHH)
PF02833
(DHHA2) 		3 ALA A 391
ASN A 394
LEU A 395
 None
 0.36A 5i1nB-2qb6A:
undetectable		 5i1nB-2qb6A:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qna IMPORTIN SUBUNIT
BETA-1

(Homo sapiens) 		PF13513
(HEAT_EZ) 		3 ALA A 237
ASN A 240
LEU A 241
 None
 0.33A 5i1nB-2qnaA:
undetectable		 5i1nB-2qnaA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ALA A 482
ASN A 485
LEU A 486
 None
 0.31A 5i1nB-2qt6A:
undetectable		 5i1nB-2qt6A:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vak SIGMA A

(Avian
orthoreovirus) 		PF03084
(Sigma_1_2) 		3 ALA A 295
ASN A 298
LEU A 299
 None
 0.39A 5i1nB-2vakA:
undetectable		 5i1nB-2vakA:
5.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vea PHYTOCHROME-LIKE
PROTEIN CPH1

(Synechocystis
sp. PCC 6803) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		3 ALA A 503
ASN A 506
LEU A 507
 None
 0.39A 5i1nB-2veaA:
undetectable		 5i1nB-2veaA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrs SIGMA-C CAPSID
PROTEIN

(Avian
orthoreovirus) 		PF04582
(Reo_sigmaC) 		3 ALA A 127
ASN A 130
LEU A 131
 None
 0.37A 5i1nB-2vrsA:
undetectable		 5i1nB-2vrsA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5f ASPARTATE_TYROSINE_P
HENYLALANINE
PYRIDOXAL-5'
PHOSPHATE-DEPENDENT
AMINOTRANSFERASE

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		3 ALA A 250
ASN A 253
LEU A 254
 None
 0.37A 5i1nB-2x5fA:
undetectable		 5i1nB-2x5fA:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ysz AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 2
AND AMYLOID BETA A4
PROTEIN

(Mus musculus) 		PF00640
(PID)
PF10515
(APP_amyloid) 		3 ALA A  40
ASN A  43
LEU A  44
 None
 0.36A 5i1nB-2yszA:
undetectable		 5i1nB-2yszA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afe HYDROXYLASE,
PUTATIVE

(Mycobacterium
tuberculosis) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		3 ALA A  15
ASN A  18
LEU A  19
 None
 0.38A 5i1nB-3afeA:
undetectable		 5i1nB-3afeA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2q UNCHARACTERIZED
CONSERVED PROTEIN

(Methanococcus
maripaludis) 		no annotation 3 ALA A 358
ASN A 361
LEU A 362
 None
 0.38A 5i1nB-3c2qA:
undetectable		 5i1nB-3c2qA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		3 ALA A  47
ASN A  50
LEU A  51
 None
 0.38A 5i1nB-3cghA:
undetectable		 5i1nB-3cghA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7a UPF0201 PROTEIN
PH1010

(Pyrococcus
horikoshii) 		PF01877
(RNA_binding) 		3 ALA A  26
ASN A  29
LEU A  30
 None
 0.29A 5i1nB-3d7aA:
undetectable		 5i1nB-3d7aA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7h DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Vibrio cholerae) 		no annotation 3 ALA A  94
ASN A  97
LEU A  98
 None
 0.34A 5i1nB-3e7hA:
undetectable		 5i1nB-3e7hA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcd LYASE

(uncultured
bacterium) 		no annotation 3 ALA A  85
ASN A  88
LEU A  89
 None
 0.14A 5i1nB-3fcdA:
undetectable		 5i1nB-3fcdA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 ALA B   4
ASN B   7
LEU B   8
 None
 0.26A 5i1nB-3hhsB:
undetectable		 5i1nB-3hhsB:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hur ALANINE RACEMASE

(Oenococcus oeni) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 ALA A  18
ASN A  21
LEU A  22
 None
 0.40A 5i1nB-3hurA:
undetectable		 5i1nB-3hurA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hww 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Escherichia
coli) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		3 ALA A  82
ASN A  85
LEU A  86
 NA  A 564 (-3.2A)
None
None
 0.33A 5i1nB-3hwwA:
undetectable		 5i1nB-3hwwA:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k85 D-GLYCERO-D-MANNO-HE
PTOSE 1-PHOSPHATE
KINASE

(Bacteroides
thetaiotaomicron) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 ALA A 317
ASN A 320
LEU A 321
 None
 0.22A 5i1nB-3k85A:
undetectable		 5i1nB-3k85A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll3 GLUCONATE KINASE

(Lactobacillus
acidophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ALA A 381
ASN A 384
LEU A 385
 None
 0.22A 5i1nB-3ll3A:
undetectable		 5i1nB-3ll3A:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzn GLUCARATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF13378
(MR_MLE_C) 		3 ALA A 183
ASN A 186
LEU A 187
 None
 0.37A 5i1nB-3mznA:
undetectable		 5i1nB-3mznA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3b RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
SUBUNIT BETA

(Escherichia
coli) 		no annotation 3 ALA B 261
ASN B 264
LEU B 265
 None
PEO  B 322 ( 4.4A)
None
 0.37A 5i1nB-3n3bB:
undetectable		 5i1nB-3n3bB:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot5 UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Listeria
monocytogenes) 		PF02350
(Epimerase_2) 		3 ALA A 156
ASN A 159
LEU A 160
 None
 0.40A 5i1nB-3ot5A:
undetectable		 5i1nB-3ot5A:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozv FLAVOHEMOGLOBIN

(Cupriavidus
necator) 		no annotation 3 ALA B 380
ASN B 383
LEU B 384
 None
 0.38A 5i1nB-3ozvB:
undetectable		 5i1nB-3ozvB:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0s CAPSID PROTEIN VP

(Lepidopteran
iteradensovirus
1) 		PF01057
(Parvo_NS1) 		3 ALA A 336
ASN A 339
LEU A 340
 None
 0.29A 5i1nB-3p0sA:
undetectable		 5i1nB-3p0sA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF02645
(DegV) 		3 ALA A 241
ASN A 244
LEU A 245
 None
 0.32A 5i1nB-3pl5A:
undetectable		 5i1nB-3pl5A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE

(Helicobacter
pylori) 		PF01370
(Epimerase) 		3 ALA A 118
ASN A 121
LEU A 122
 None
 0.35A 5i1nB-3sxpA:
undetectable		 5i1nB-3sxpA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ALA A 483
ASN A 486
LEU A 487
 None
 0.27A 5i1nB-3t6wA:
undetectable		 5i1nB-3t6wA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b18 IMPORTIN SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		3 ALA A 235
ASN A 238
LEU A 239
 None
 0.39A 5i1nB-4b18A:
undetectable		 5i1nB-4b18A:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		3 ALA A 208
ASN A 211
LEU A 212
 None
 0.39A 5i1nB-4cczA:
undetectable		 5i1nB-4cczA:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgr PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		3 ALA A 216
ASN A 219
LEU A 220
 None
 0.37A 5i1nB-4cgrA:
undetectable		 5i1nB-4cgrA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9i DIAMINOPROPIONATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00291
(PALP) 		3 ALA A 153
ASN A 156
LEU A 157
 None
 0.39A 5i1nB-4d9iA:
undetectable		 5i1nB-4d9iA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvg DIAPHANOUS PROTEIN

(Entamoeba
histolytica) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		3 ALA B 273
ASN B 276
LEU B 277
 None
 0.33A 5i1nB-4dvgB:
undetectable		 5i1nB-4dvgB:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Bacillus
subtilis) 		PF02350
(Epimerase_2) 		3 ALA A 155
ASN A 158
LEU A 159
 None
 0.36A 5i1nB-4fkzA:
undetectable		 5i1nB-4fkzA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2w PROTEIN UNC-45

(Caenorhabditis
elegans) 		PF11701
(UNC45-central) 		3 ALA A 163
ASN A 166
LEU A 167
 None
 0.29A 5i1nB-4i2wA:
undetectable		 5i1nB-4i2wA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4is8 NUCLEAR RECEPTOR
SUBFAMILY 5 GROUP A
MEMBER 2

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 ALA A 423
ASN A 426
LEU A 427
 None
 0.32A 5i1nB-4is8A:
undetectable		 5i1nB-4is8A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4s NUCLEOCAPSID PROTEIN

(SFTS
phlebovirus) 		PF05733
(Tenui_N) 		3 ALA A 131
ASN A 134
LEU A 135
 None
 0.16A 5i1nB-4j4sA:
undetectable		 5i1nB-4j4sA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jiu PROABYLYSIN

(Pyrococcus
abyssi) 		PF01863
(DUF45) 		3 ALA A  45
ASN A  48
LEU A  49
 None
 0.31A 5i1nB-4jiuA:
undetectable		 5i1nB-4jiuA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhu ECTOINE HYDROXYLASE

(Sphingopyxis
alaskensis) 		PF05721
(PhyH) 		3 ALA A  64
ASN A  67
LEU A  68
 None
 0.36A 5i1nB-4mhuA:
undetectable		 5i1nB-4mhuA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6s C-PHYCOCYANIN BETA
SUBUNIT

(Thermosynechococcus
vulcanus) 		PF00502
(Phycobilisome) 		3 ALA B  26
ASN B  29
LEU B  30
 None
 0.25A 5i1nB-4n6sB:
undetectable		 5i1nB-4n6sB:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Methanocaldococcus
jannaschii) 		PF02350
(Epimerase_2) 		3 ALA A 150
ASN A 153
LEU A 154
 None
 0.40A 5i1nB-4nesA:
undetectable		 5i1nB-4nesA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvr UNCHARACTERIZED
HYPOTHETICAL PROTEIN
FTT_1539C

(Francisella
tularensis) 		no annotation 3 ALA A 336
ASN A 339
LEU A 340
 None
 0.33A 5i1nB-4qvrA:
undetectable		 5i1nB-4qvrA:
5.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpc PUTATIVE ALPHA/BETA
HYDROLASE

(Desulfitobacterium
hafniense) 		PF12697
(Abhydrolase_6) 		3 ALA A 137
ASN A 140
LEU A 141
 None
 0.32A 5i1nB-4rpcA:
undetectable		 5i1nB-4rpcA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uad IMPORTIN SUBUNIT
ALPHA-7

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		3 ALA A 233
ASN A 236
LEU A 237
 None
 0.39A 5i1nB-4uadA:
undetectable		 5i1nB-4uadA:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wh0 PUTATIVE HYDROLASE

(Pseudomonas
aeruginosa) 		PF00857
(Isochorismatase) 		3 ALA A 193
ASN A 196
LEU A 197
 None
 0.24A 5i1nB-4wh0A:
undetectable		 5i1nB-4wh0A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)

(Clostridium
acetobutylicum) 		PF07470
(Glyco_hydro_88) 		3 ALA A  98
ASN A 101
LEU A 102
 None
 0.37A 5i1nB-4wu0A:
undetectable		 5i1nB-4wu0A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 ALA A 921
ASN A 924
LEU A 925
 None
 0.37A 5i1nB-4wz9A:
undetectable		 5i1nB-4wz9A:
3.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xky DIHYDRODIPICOLINATE
SYNTHASE

(Bacteroides
thetaiotaomicron) 		PF00701
(DHDPS) 		3 ALA A 294
ASN A 297
LEU A 298
 None
 0.33A 5i1nB-4xkyA:
undetectable		 5i1nB-4xkyA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yet SUPEROXIDE DISMUTASE

(Babesia bovis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 ALA A 188
ASN A 191
LEU A 192
 None
 0.39A 5i1nB-4yetA:
undetectable		 5i1nB-4yetA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT K

(Oryctolagus
cuniculus) 		PF10075
(CSN8_PSD8_EIF3K) 		3 ALA K  73
ASN K  76
LEU K  77
 None
 0.34A 5i1nB-5a5tK:
undetectable		 5i1nB-5a5tK:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cl2 SPORULATION-CONTROL
PROTEIN SPO0M

(Bacillus
subtilis) 		PF07070
(Spo0M) 		3 ALA A 146
ASN A 149
LEU A 150
 None
 0.28A 5i1nB-5cl2A:
undetectable		 5i1nB-5cl2A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyu CONSERVED MEMBRANE
PROTEIN

(Mycolicibacterium
smegmatis) 		PF05108
(T7SS_ESX1_EccB) 		3 ALA A 427
ASN A 430
LEU A 431
 None
 0.28A 5i1nB-5cyuA:
undetectable		 5i1nB-5cyuA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d2e MLNE

(Bacillus
velezensis) 		PF08659
(KR) 		3 ALA A 319
ASN A 322
LEU A 323
 None
 0.28A 5i1nB-5d2eA:
undetectable		 5i1nB-5d2eA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dld UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Burkholderia
vietnamiensis) 		PF02350
(Epimerase_2) 		3 ALA A 153
ASN A 156
LEU A 157
 None
 0.37A 5i1nB-5dldA:
undetectable		 5i1nB-5dldA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0o COHESIN SUBUNIT
PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P

(Lachancea
thermotolerans) 		no annotation 3 ALA A 487
ASN A 490
LEU A 491
 None
 0.28A 5i1nB-5f0oA:
undetectable		 5i1nB-5f0oA:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9a ADHESIN BINDING
FUCOSYLATED
HISTO-BLOOD GROUP
ANTIGEN,ADHESIN,ADHE
SIN BINDING
FUCOSYLATED
HISTO-BLOOD GROUP
ANTIGEN

(Helicobacter
pylori) 		no annotation 3 ALA A  62
ASN A  65
LEU A  66
 None
 0.39A 5i1nB-5f9aA:
undetectable		 5i1nB-5f9aA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602) 		no annotation 3 ALA A 257
ASN A 260
LEU A 261
 None
 0.34A 5i1nB-5gt5A:
undetectable		 5i1nB-5gt5A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihe DNA POLYMERASE II
SMALL SUBUNIT

(Pyrococcus
abyssi) 		PF00149
(Metallophos) 		3 ALA A 430
ASN A 433
LEU A 434
 None
 0.37A 5i1nB-5iheA:
undetectable		 5i1nB-5iheA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j4a TRNA NUCLEASE CDIA

(Burkholderia
pseudomallei) 		no annotation 3 ALA A 300
ASN A 303
LEU A 304
 None
 0.30A 5i1nB-5j4aA:
undetectable		 5i1nB-5j4aA:
28.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PUTATIVE PRE-MRNA
SPLICING FACTOR

(Chaetomium
thermophilum) 		PF08084
(PROCT) 		3 ALA B2052
ASN B2055
LEU B2056
 None
 0.23A 5i1nB-5m59B:
undetectable		 5i1nB-5m59B:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Psychrobacter
arcticus) 		PF13393
(tRNA-synt_His) 		3 ALA A 332
ASN A 335
LEU A 336
 None
 0.18A 5i1nB-5m8hA:
undetectable		 5i1nB-5m8hA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n3u PHYCOCYANOBILIN
LYASE SUBUNIT ALPHA

(Nostoc sp. PCC
7120) 		no annotation 3 ALA A  22
ASN A  25
LEU A  26
 None
 0.28A 5i1nB-5n3uA:
undetectable		 5i1nB-5n3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 3 ALA A 427
ASN A 430
LEU A 431
 None
 0.35A 5i1nB-5nqdA:
undetectable		 5i1nB-5nqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5och -

(-) 		no annotation 3 ALA B 714
ASN B 717
LEU B 718
 None
 0.13A 5i1nB-5ochB:
undetectable		 5i1nB-5ochB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 3 ALA B 222
ASN B 225
LEU B 226
 None
 0.34A 5i1nB-5swiB:
undetectable		 5i1nB-5swiB:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		3 ALA A 295
ASN A 298
LEU A 299
 None
 0.36A 5i1nB-5weoA:
undetectable		 5i1nB-5weoA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A

(Pyrococcus
abyssi) 		no annotation 3 ALA A 222
ASN A 225
LEU A 226
 None
 0.40A 5i1nB-5wt3A:
undetectable		 5i1nB-5wt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wti CRISPR-ASSOCIATED
PROTEIN

(Bacillus
thermoamylovorans) 		no annotation 3 ALA Z 955
ASN Z 958
LEU Z 959
 None
 0.30A 5i1nB-5wtiZ:
undetectable		 5i1nB-5wtiZ:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E

(Staphylococcus
aureus) 		no annotation 3 ALA A  85
ASN A  88
LEU A  89
 None
 0.35A 5i1nB-5xoeA:
undetectable		 5i1nB-5xoeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 ALA B1054
ASN B1057
LEU B1058
 None
 0.27A 5i1nB-5xogB:
undetectable		 5i1nB-5xogB:
2.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0s THERMOTOGA MARITIMA
TMCAL

(Thermotoga
maritima) 		no annotation 3 ALA A 212
ASN A 215
LEU A 216
 None
 0.37A 5i1nB-5y0sA:
undetectable		 5i1nB-5y0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6acd -

(-) 		no annotation 3 ALA A1002
ASN A1005
LEU A1006
 None
 0.39A 5i1nB-6acdA:
undetectable		 5i1nB-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6an0 HISTIDINOL
DEHYDROGENASE

(Elizabethkingia
anophelis) 		PF00815
(Histidinol_dh) 		3 ALA A 314
ASN A 317
LEU A 318
 None
 0.38A 5i1nB-6an0A:
undetectable		 5i1nB-6an0A:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cet GATOR COMPLEX
PROTEIN NPRL2

(Homo sapiens) 		no annotation 3 ALA N 223
ASN N 226
LEU N 227
 None
 0.40A 5i1nB-6cetN:
undetectable		 5i1nB-6cetN:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6egx STRUCTURAL PROTEIN
VP1

(Sacbrood virus) 		no annotation 3 ALA A  89
ASN A  92
LEU A  93
 None
 0.19A 5i1nB-6egxA:
undetectable		 5i1nB-6egxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elc VARIANT SURFACE
GLYCOPROTEIN

(Trypanosoma
brucei) 		no annotation 3 ALA A  59
ASN A  62
LEU A  63
 None
 0.34A 5i1nB-6elcA:
undetectable		 5i1nB-6elcA:
undetectable